Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions
Номер патента: WO2002044412A8
Опубликовано: 11-12-2003
Автор(ы): Joshua S Salafsky
Принадлежит: Joshua S Salafsky
Опубликовано: 11-12-2003
Автор(ы): Joshua S Salafsky
Принадлежит: Joshua S Salafsky
Реферат: A surface-selective nonlinear optical technique, such as second harmonic or sum frequency generation, is used to detect reactions between surface-attached probes and labeled targets or used to perform imaging of a surface. The surface-selective optical technique allows detection of only those target components near the interface while ignoring those present in the sample bulk. In addition, the direction of the nonlinear light is scattered from the surface in a well-defined direction and because of this, its incidence at a detector some distance from the surface may be easily mapped to a specific and known location on the surface.
Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions
Номер патента: CA2430430A1. Автор: Joshua Salafsky. Владелец: Individual. Дата публикации: 2002-06-06.