Orally administered controlled drug delivery system providing temporal and spatial control.
Номер патента: AP1659A
Опубликовано: 06-09-2006
Автор(ы): Himadri Sen, John N Staniforth, Naresh Talwar
Принадлежит: Ranbaxy Laboratories Ltd
Опубликовано: 06-09-2006
Автор(ы): Himadri Sen, John N Staniforth, Naresh Talwar
Принадлежит: Ranbaxy Laboratories Ltd
Реферат: A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to float so that it is retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug, resulting in sustained release of the drug (temporla control). A preferred once daily ciprofloxacin formulation comprises 69.9% ciprofloxacin base, 0.34% sodium alginate, 1.03% xanthan gum, 13.7% sodium bicarbonate, 12.1% cross-linked polyvinylpyrrolidone, and optionally other pharmaceutical excipients, the formulation being in the form of a coated or uncoated tablet or capsule.
Drug delivery system, administered orally, providing temporal and spatial control
Номер патента: BR9913696A. Автор: Sen Himadri,Naresh Talwar,John H Staniforth. Владелец: Ranbaxy Lab Ltd. Дата публикации: 2001-10-09.