Substituted imidazo-pyrimidines,-pyrazines and triazines method for their preparation and pharmaceutical compositions
Реферат: Compounds having the formula (I) <CHEM> and their pharmaceutically acceptable salts, wherein one or two of A1, A2, A3, and A4 is N, and the remaining A1, A2, A3, and A4 are CH, provided that if A4 is N, then one of A1, A2, and A3 is also N, and provided that one of A1, A2, and A3 may be CX where X is halo; and each of R1, R2, and R3 is independently hydrogen, C1-C4 alkyl, C1-C4, alkoxy, allyloxy, benzyloxy, (C1-C4 alkyl) thio, (C1-C4 alkyl) sulfinyl, (C1-C4 alkyl)sulfonyl, hydroxy, halo, cyano, nitro, amino, mono- or di-(C1-C4alkyl)amino, trifluoromethyl, or Z-Q-substituted C1-C4 alkoxy, wherein Q is oxygen, sulfur, sulfinyl, sulfonyl, or a bond, and Z is C1-C4 alkyl, phenyl or phenyl substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, nitro, amino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, or C1-C4 alkylsulfonyl are ionotropic agents or intermediates thereto.
Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them
Номер патента: CA2689985C. Автор: Heinz-Werner Kleemann,Thomas Boehme,Stefania Pfeiffer-Marek,Jean-Michel Altenburger,Uwe Gerlach,Sergio Mallart,Henning Vollert,Dirk Gretzke. Владелец: Sanofi Aventis France. Дата публикации: 2015-07-14.