Suppressive exosomes in cancer and for immunosuppression
Номер патента: EP3765032A1
Опубликовано: 20-01-2021
Автор(ы): Mauro Poggio, Robert Blelloch, Tianyi HU
Принадлежит: UNIVERSITY OF CALIFORNIA
Опубликовано: 20-01-2021
Автор(ы): Mauro Poggio, Robert Blelloch, Tianyi HU
Принадлежит: UNIVERSITY OF CALIFORNIA
Реферат: Suppressive extracellular vesicles (EVs) such as PD-L1-bearing exosomes are produced by cancer cells and promote systemic suppression of the immune system, enabling tumors to escape immune surveillance. Inhibitors of suppressive EVs reduce the suppressive activity and/or the production of suppressive EVs, relieving systemic immunosuppression, and may be use to increase the efficacy of a co-administered immunotherapy. Additionally, engineered cancer cells that have an impaired capacity to produce PD-L1-bearing exosomes can be administered to prime the immune system against resident tumors, overcoming the systemic suppression of the immune system by cancer cells. Also, exogenously produced PD-L1- bearing exosomes may be administered to a subject for the treatment of an immune-related condition or to promote therapeutic immunosuppression.
Detection and treatment of daughter number variations in cancer cells
Номер патента: US11952593B2. Автор: Hong Xue. Владелец: PharmacoGenetics Ltd. Дата публикации: 2024-04-09.