Liposomes as vehicles for therapeutic and diagnostic substances
Номер патента: AU6420380A
Опубликовано: 14-05-1981
Автор(ы): John D. Baldeschwieler, Marcia R. Mauk, Mitree M. Ponpipom, Ronald Carl Gamble, Tsung-Ying Shen
Принадлежит: California Institute of Technology CalTech, Merck and Co Inc
Опубликовано: 14-05-1981
Автор(ы): John D. Baldeschwieler, Marcia R. Mauk, Mitree M. Ponpipom, Ronald Carl Gamble, Tsung-Ying Shen
Принадлежит: California Institute of Technology CalTech, Merck and Co Inc
Реферат: Lipid vesicles comprise a lipid bilayer which includes an analog of a cell-surface receptor such as dicetyl phosphate, stearylamine, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-L-fucopyranoside, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 1-thio-a- D-mannopyranoside, 6-(5-cholesten- 3-yloxy)hexyl 2-acetamido-3-deoxy- 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 6-amino-6-deoxy-1-thio- β-D-galactopyranoside or 6-(5-cholesten- 3p-yloxy)hexyl 6-amino-6-deoxy-1- thio-a-D-mannopyranoside, together with cholesterol, distearoyl phospatidylcholine and an effective amount of a physiologically compatible radioactive tracer or a cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to mammalian, including human, hosts and have been found to release the contents of the vesicles in a predetermined manner, and in some cases to be rapidly concentrated in the lymphatic system and<sub>/</sub>or liver, lungs, or spleen of the host.
Dispersions of lipids for use as therapeutic and cosmetic agents and intracellular delivery vehicles
Номер патента: US20060008483A1. Автор: Thierry Legon,Frederic Henot,Roland Frebillot,Sebastien Baudart. Владелец: Biotech Tools SA. Дата публикации: 2006-01-12.