Nme2cas9 inlaid domain fusion proteins
Номер патента: EP4426821A1
Опубликовано: 11-09-2024
Автор(ы): Erik SONTHEIMER, Han Zhang, Nathan BAMIDELE, WEN Xue, Xiaolong DONG
Принадлежит: University of Massachusetts UMass
Опубликовано: 11-09-2024
Автор(ы): Erik SONTHEIMER, Han Zhang, Nathan BAMIDELE, WEN Xue, Xiaolong DONG
Принадлежит: University of Massachusetts UMass
Реферат: The present invention is related to the field of gene editing. In particular, the gene editing is directed toward single nucleotide base editing. For example, such single nucleotide base editing results in a conversion of a mutated base pair to a wild type base pair. The high accuracy and precision of the presently disclosed single nucleotide base gene editor is accomplished by a fusion protein including an NmeCas9 nuclease and an inlaid nucleotide deaminase protein domain. The Nme2Cas9 protospacer interacting domain may be replaced with an SmuCas9 protospacer interacting domain.
Nme2cas9 inlaid domain fusion proteins
Номер патента: CA3236778A1. Автор: WEN Xue,Han Zhang,Xiaolong DONG,Erik SONTHEIMER,Nathan BAMIDELE. Владелец: University of Massachusetts Medical School UMMS. Дата публикации: 2023-05-11.