Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity
Номер патента: CA2114968A1
Опубликовано: 26-08-1994
Автор(ы): Agis Kydonieus, John Wille
Принадлежит: Individual
Опубликовано: 26-08-1994
Автор(ы): Agis Kydonieus, John Wille
Принадлежит: Individual
Реферат: TRANSDERMAL TREATMENT WITH MAST CELL DEGRANULATING AGENTS FOR DRUG-INDUCED HYPERSENSITIVITY ABSTRACT Methods and compositions for inhibiting or preventing the skin irritating or sensitizing effects of a skin irritating or sensitizing component of a dermal or transdermal drug delivery system are disclosed. The composition comprises a mast cell degranulating agent which is capable of inducing a state of immunological tolerance to the skin sensitizing agent by delivery prior to, or at the onset of transdermal drug delivery. Such an agent, preferably cis-urocanic acid or an analogue or metabolite thereof, can be administered before, during or after each transdermal drug delivery to achieve immune tolerance countersensitization. Alternatively, the agent can be used to induce countersensitization. The agent is preferably capable of permeating the epidermis and is administered transdermally. Novel methods and compositions comprising cis-urocanic acid or an analogue or metabolite thereof to obtain anti-inflammatory effects are also disclosed.
Use of n-(6,8,8-trimethyl-8,9-dihydrofuro[3,2-h]quinolin-5-yl)acetamide as an agent for phototherapy of psoriasis and psoriatic arthritis
Номер патента: RU2686692C1. Автор: Владимир Александрович Кузьмин,Елена Владимировна Трубникова,Елена Сергеевна Мутных,Алексей Борисович Шевелев,Юлия Константиновна Бирюкова,Евгений Никифорович Ходот,Татьяна Дмитриевна Некипелова,Владимир Анатольевич Волнухин,Марина Валерьевна Зылькова,Ольга Николаевна Криушкина. Владелец: Федеральное государственное бюджетное учреждение науки Институт биохимической физики им. Н.М. Эмануэля Российской академии наук (ИБХФ РАН). Дата публикации: 2019-04-30.