Novel Synthesis of Nucleoside 5'-Triphosphates and Their Derivatives

Disclosed are compounds of nucleoside 5′-triphosphates of formula (I), or derivatives thereof, or pharmaceutically acceptable salts of said nucleoside 5′-triphosphates or said derivatives, wherein the Base of formula (I) is Adenine (A), Cytosine (C), Guanine (G), Thymine (T), Uracil (U), modified nucleobase or unnatural nucleobase; R 1 is H or OH, R 2 is H or OH, X is independently selected from the group consisting of O, S and Se; and Y is independently selected from the group consisting of O, B (borano, or BH 3 ), S, and Se. Also disclosed are processes of preparing the compounds of formula (I), said process comprising steps according to Scheme A:

Methods for structural determination of selenium derivatized nucleic acid complexes

Novel Compounds and Derivatizations of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics

Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of conducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy

Disclosed are compositions which can mimic DNA and/or RNA in cells of a subject and methods of using them as a substrate in testing efficacy of one or more compositions in reducing and/or preventing radiation, such as ultraviolet (UV) radiation-caused DNA and/or RNA damage of said subject. Also disclosed are systems related to the disclosed methods.

核苷5＇-三磷酸和它们的衍生物的新颖合成

本发明公开了式(I)的核苷5'‑三磷酸的化合物、或其衍生物、或所述核苷5'‑三磷酸或所述衍生物的药学上可接受的盐， 式(I)其中式(I)的碱基是腺嘌呤(A)、胞嘧啶(C)、鸟嘌呤(G)、胸腺嘧啶(T)、尿嘧啶(U)、修饰的核苷碱基或非天然的核苷碱基；R 1 是H或OH，R 2 是H或OH，X独立地选自O、S和Se；且Y独立地选自O、B(硼代或BH 3 )、S和Se。也公开了制备式(I)化合物的方法，所述方法包括根据方案A的步骤：方案A