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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 4130. Отображено 100.
23-02-2012 дата публикации

Saliva collection device

Номер: US20120046574A1
Автор: James G. Skakoon
Принадлежит: Reflex Medical Corp

A device for collecting oral fluid includes a mouthpiece with a fluid inlet connected to a collection chamber. The collection chamber includes a collecting vessel, a venting outlet, and an access port. The venting outlet may be covered by a liquid-impervious or resistant membrane, such as a hydrophobic membrane, and the access port is suitable for removing some or all of the collected fluid. This arrangement allows a saliva donor to continuously spit saliva and blow air into the closed collection chamber, without pressure build-up in the collection chamber, and without the need for the donor to release from the device until the desired oral fluid volume is collected. A valve, including a check valve may be in the saliva flow stream and baffles and structure creating a tortuous path may be utilized to keep saliva away from the membrane.

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Номер записи: 1
05-04-2012 дата публикации

Diagnostic device and method for sensing hydration state of a mammalian subject

Номер: US20120083711A1
Автор: Andrew S. Goldstein, Frank Bellizzi
Принадлежит: HYDRADX Inc

Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

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Номер записи: 2
19-04-2012 дата публикации

Device for assaying analytes in bodily fluids

Номер: US20120094303A1
Автор: Leslie Wilson, Matthias W. Engel, Paul Johnson
Принадлежит: ulti med Products International GmbH

A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. Further, the base of the container has a central elevation via which the sample of body fluid can be conveyed from the sampler, by compression thereof on the elevation, to the at least one test strip.

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Номер записи: 3
06-12-2012 дата публикации

Diagnostic oral device

Номер: US20120309042A1
Автор: Elizabeth Gittins, Harsh M. Trivedi, Madhusudan Patel, Sharon Kennedy
Принадлежит: Colgate Palmolive Co

Described herein are devices and methods for identifying the existence of an oral condition in a subject.

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Номер записи: 4
20-12-2012 дата публикации

Device for identifying oral conditions

Номер: US20120322023A1
Автор: Deborah Peru, Douglas Hohlbein, Elizabeth Gittens, Harsh M. Trivedi, Madhusudan Patel, Sharon Kennedy
Принадлежит: Colgate Palmolive Co

The present invention relates to devices and systems for detecting the existence of oral conditions.

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Номер записи: 5
17-01-2013 дата публикации

Fluid sample collecting and analyzing apparatus and method

Номер: US20130017623A1
Автор: John Wu, Waiping Ng
Принадлежит: Ameditech Inc

A spongy swab ( 16 ) is mounted against the distal face ( 15 ) of a piston ( 14 ) at the end of a push-rod ( 12 ). Once humected with a sample fluid, the swab and piston assembly is inserted into a tubular body ( 30 ) like the plunger of a syringe. As the swab is pushed and squeezed against the distal end ( 20 ) of the body up to a trippable stop, part of the fluid is excreted into a chromatographic immunoassay testing device ( 21 ) through a first aperture ( 19 ) in a distal section of the body. The remainder of the sample is kept in a sealed chamber ( 7 ) between the piston and the end wall of the tubular body until it is excreted through a second aperture ( 23 ) for a secondary test by pushing the piston beyond the trippable stop. That preserves the sample within the spongy swab that has been used to collect it; thus preventing the adsorption of the analytes on the surfaces of the sealed chamber, and to provide a convenient and rapid way to extract the remainder of the specimen in a syringe-like manner.

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Номер записи: 6
24-01-2013 дата публикации

Device for assaying analytes in bodily fluids

Номер: US20130022517A1
Автор: Leslie Wilson, Matthias W. Engel, Paul Johnson
Принадлежит: EXPRESS DIAGNOSTICS INT'L Inc

A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. The sampling element can include an indicator strip for determining whether the amount of liquid sample sufficient for carrying out an assay.

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Номер записи: 7
18-04-2013 дата публикации

SAMPLING AND TESTING DEVICE FOR THE HUMAN OR ANIMAL BODY

Номер: US20130096400A1
Автор: Dahl Steven David, Maschmann Jennifer, PARSONS SEAN ANDREW, Spink Tim Ian, Wilson Stephen Robert, Wong Kon Euan Gerard
Принадлежит: RESPIRIO PTY LTD

A device () is provided that is configured to indicate the presence or absence of one or more biological entities in a biological sample. The device comprises a sampling portion (), the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; and a test portion () in fluid engagement with the sampling portion, the test portion comprising one or more test zones (). The sampling portion and test portion are configured such that at least a portion of the sample received by the sampling portion is transferable to the test portion such as to contact one or more of the test zones, and wherein each test zone is configured to indicate the presence or absence of one or more biological entities in the sample. 1. A device comprising:a substantially rigid housing;a sampling portion located outside the housing, the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; anda test portion located at least partially inside the housing and in fluid engagement with the sampling portion, the test portion comprising one or more test zones,wherein the sampling portion and the test portion are configured such that at least a portion of the biological sample received by the sampling portion is transferable to the test portion by capillary action such as to contact one or more of the test zones, and wherein each of the one or more test zones is configured to indicate a presence or absence of one or more biological entities in the biological sample.2. The device of claim 1 , wherein the biological sample comprises any one or more of the following: blood claim 1 , serum claim 1 , plasma claim 1 , saliva claim 1 , sputum claim 1 , urine ...

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Номер записи: 8
30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9
Автор: A. David Boccuti, Christopher J. Morse, Donald E. Chickering, III, Greg Fisher, Javier Gonzalez-Zugasti, Maisam Dadgar, Mark Michelman, Ramin Haghgooie, Richard L. Miller, Scott James, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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Номер записи: 9
13-06-2013 дата публикации

Oral Fluid Sample Collection Device With Indicator and Method

Номер: US20130149728A1
Автор: Debra Owen Stabu, Nathan L. Smith
Принадлежит: Cytosignet Inc

Provided are methods and devices used for determining the presence or absence of a contaminant in the sample of oral fluid. The method involves contacting a substrate having a detectable reporter with a sample of oral fluid and, based on determining a signal from the detectable reporter determining the presence or absence of a contaminant in the sample of oral fluid. The invention is useful for detecting lactose, milk, colostrum, blood, hemoglobin, whole cells, and combinations thereof. The method can be used for detecting oral contaminants in oral fluid samples obtained from any mammal, including neonatal ungulates.

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Номер записи: 10
20-06-2013 дата публикации

Accurate Measurement of glutathione for disease diagnosis and drug metabolite screening

Номер: US20130158886A1
Автор: Kingston Howard M., Pamukcu Mehmet
Принадлежит:

A method of measuring and calculating (preferably by a computer with output to a user) tGSH (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tGSH and related diagnostic assays in blood or tissue from a patient. 2. The method according to wherein a human having a GSH/GSSG ratio trend positive or negative that that is measured relevant to treatment has that treatment assessed based on the statistically significant numeric change before and after treatment.3. The method according to wherein a human having a tGSH claim 1 , GSSG claim 1 , GSH/GSSG ratio and optionally CGSH suite of relevant to some exposure and or treatment providing an assessment of a diseased state and or trend in that state.4. The method according to wherein a human having a GSH/GSSG ratio within the range 15-200 is vulnerable to disease including but not limited to autism and chronic fatigue syndrome.5. The method according to wherein a tGSH concentration of 2.8-3.0 micromoles tGSH per gram of blood is prognostic of autism in children and young adults claim 1 , and a GSH level of 2.2-2.4 micromoles per gram of blood is prognostic of autism in children and young adults claim 1 , which tGSH and GSH values may be considered separately or together.6. The method according to wherein a tGSH concentration that is determined to be an individual concentration based on toxins that cause the shift from the normal regional population including derived from the list of toxins and toxicants such as methylmercury claim 1 , ionic mercury claim 1 , and mercury species claim 1 , cadmium claim 1 , lead claim 1 , aluminum claim 1 , antimony claim 1 , arsenic species claim 1 , hexavalent chromium claim 1 , chlorinated pesticides herbicides fungicides and insecticides claim 1 , organiophosphate pesticides claim 1 , endocrine disruptors claim 1 , polycyclic aromatic hydrocarbons claim 1 , brominated flame retardants claim 1 , ...

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Номер записи: 11
26-09-2013 дата публикации

BIOLOGICAL FLUID COLLECTION SYSTEM

Номер: US20130253457A1
Автор: SHUBIN, SR. Steven A.
Принадлежит:

Biological fluid collection. At least some of the illustrative embodiments are systems including a sleeve of elastomeric material and a receptacle coupled to the sleeve. The sleeve may include: first and second ends, each end comprising respectively a first and a second orifice; and a passage extending between the first and second orifices. The receptacle may include: a side wall and a bottom that define an interior volume and a height; and an entrance portion that defines an internal diameter, wherein the height of receptacle is at least half the internal diameter. The receptacle may mechanically couple to the sleeve such that the interior volume is fluidly coupled to the passage of the sleeve. 1. A device comprising: first and second ends, each end comprising respectively a first and a second orifice; and', 'a passage extending between the first and second orifices;, 'a sleeve of elastomeric material, the sleeve defines a side wall and a bottom that define an interior volume and a height;', 'an entrance portion that defines an internal diameter, wherein the height of receptacle is at least half the internal diameter;, 'a receptacle comprisingthe receptacle mechanically coupled to the sleeve such that the interior volume is fluidly coupled to the passage of the sleeve.2. The device of wherein the receptacle further comprises a connection fixture disposed on an exterior surface of the side wall of the receptacle claim 1 , the receptacle mechanically coupled to the sleeve by way of the connection fixture.3. The device of further comprising a cap having a connection fixture on an inside diameter claim 2 , the connection fixture of the cap configured to mateably connect with the receptacle connection fixture.4. The system of wherein the connection fixture configured to removably accommodate a device for sealing the interior volume.5. The device of wherein the receptacle is angled from a first end to a second end.6. The device of further comprising an adapter that ...

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Номер записи: 12
13-02-2014 дата публикации

Assay Device for Testing an Analyte in Samples

Номер: US20140046215A1
Автор: Haipeng Hu, HU Lin
Принадлежит:

This invention provides an assay device for testing an analyte in samples, comprising a chamber with an opening for collecting samples, a test element, and a sound indication structure. The indication structure creates sound by vibrating after the structure deforms and would move back to the original position. The assay device is easy to operate for non-professionals. 1. An assay device for testing an analyte in samples , comprising: a chamber with an opening for collecting samples; a test element and said assay device further comprises an indication structure creating sound.2. The device according to claim 1 , wherein the indication structure creates the sound by vibration after the indication structure deforms and would move back to the original position.3. The device according to claim 2 , wherein the vibration attenuates itself without any obstructor when the indication structure moves back to the original position.4. The device according to claim 2 , wherein the indication structure does not contact other objects while vibrating.54. The device according to - claim 1 , wherein the indication structure at least comprises two elements which deform each other claim 1 , detach from each other and create sound through vibration when they move back to the original position.6. The device according to claim 5 , wherein the two elements neither contact each other nor other objects.7. The device according to claim 6 , wherein the device further comprises a cover body for closing the opening of the collecting chamber and the two elements are arranged on the collecting chamber and cover body respectively.8. The device according to claim 7 , wherein the two elements contact each other when the cover body reaches the first position on the collecting chamber; and wherein they detach from each other when the cover body reaches the second position on the collecting chamber claim 7 , so the elements are released from the pressure and generates sound through vibration when they ...

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Номер записи: 13
06-03-2014 дата публикации

Sampling System

Номер: US20140066807A1
Автор: Berndt Sjoberg, Erik Wilander, Sören Nygren, Ulf Lundkvist
Принадлежит: APROVIX AB

A sampling system comprises a mailing package; a cell sampling device comprising a flexible shaft having a handle at one end, wherein the shaft is configured to allow an individual to self collect a cell sample from mucous tissue, and a sample collecting element removably connectable with the other end of the shaft and operable to collect a cell sample from mucous tissue of an individual; and a sealable unit, wherein the unit is configured to store the sample collecting element having a cell sample thereon configured to receive the remaining components of the system for delivery to a user.

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Номер записи: 14
06-03-2014 дата публикации

Method and System for Preventing Virus-Related Obesity and Obesity Related Diseases

Номер: US20140066817A1
Автор: Kovarik Joseph E., Kovarik Katherine Rose, Zarouri Mourad
Принадлежит: NoHands, LLC

A method for preventing obesity related to infection by an adipogenic adenovirus includes obtaining a sample from a person, assaying the sample to determine whether the person has been previously infected with an adipogenic adenovirus, and if the person has not been previously infected, providing the person with at least one sensor positioned to detect when a person's hand approaches a predetermined distance from the person's face. By warning the person of undesired hand-to-face contacts, the person is able to reduce the incidence of obesity related infections. Other embodiments are directed to a kit for preventing obesity caused by infection with an adipogenic adenovirus, such kit including a container for assaying an agent indicating the presence of antibodies to Ad-36, and a sensor positioned on an item selected from the group consisting of one of a hat, a writing instrument, eye glasses, a belt, sunglasses, a bra, a shirt, and a tie. 1. A method for preventing infection by an adenovirus , comprising:obtaining a sample from a person;assaying the sample to determine whether the person has been previously infected with a predetermined adenovirus;if said assaying step indicates that such person has not been previously infected with said adenovirus, providing to the person at least one sensor positioned to detect when a person's hand approaches a predetermined distance from the person's face;reducing the incidence of hand-to-face contacts by said person due to the person being warned by said at least one sensor of occasions when the person's hands approach said person's face, said at least one sensor incorporated into a writing instrument;providing a signal generating device operatively associated with said at least one sensor and with a semiconductor device programmed to select one of a plurality of predetermined distances of proximity so that a person's hand triggers the signal generating device to warn the person that their hand is in the proximity of their mouth, ...

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Номер записи: 15
20-03-2014 дата публикации

SYSTEMS AND METHODS FOR PARENTERALLY PROCURING BODILY-FLUID SAMPLES WITH REDUCED CONTAMINATION

Номер: US20140081172A1
Автор: Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media. 120.-. (canceled)21. A method of establishing a fluid flow path between a patient and a fluid container , the method comprising:establishing fluid communication between the patient and a lumen-containing device;withdrawing a first volume of a bodily-fluid from the patient, the first volume of bodily-fluid being greater than the volume of the lumen-containing device;transferring the first volume of bodily-fluid to a fluid reservoir via the lumen-containing device;fluidically isolating the lumen-containing device from the fluid reservoir to sequester the first volume of bodily-fluid in the fluid reservoir; andestablishing fluid communication between the patient and the fluid container with the lumen-containing device.22. The method of claim 21 , whereby sequestering the first volume of bodily-fluid in the fluid reservoir sequesters dermally-residing microbes present in the first volume of bodily-fluid from the fluid flow path claim 21 , thereby reducing microbial contamination in the fluid flow path.23. The method of claim 21 , wherein the first volume of bodily-fluid is in the range of 1 ml to 5 ml.24. The method of claim 21 , wherein the first volume of bodily-fluid is in the range of 0.5 ml to 3 ml.25. The method of claim 21 , further comprising:after the first volume of bodily-fluid has been sequestered in the fluid ...

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Номер записи: 16
27-03-2014 дата публикации

SYSTEM AND METHOD FOR SAMPLING DEVICE FOR BODILY FLUIDS

Номер: US20140088460A1
Автор: Baker Andrew T., Cesa Joseph A., Cuevas Brian J., Hershey Adrienne A., Tai Kok-Ming, Tarcau Benone, Teixeira Scott M., Williams Amy G.
Принадлежит: KIMBERLY-CLARK WORLDWIDE, INC.

There is provided a device for sampling bodily fluids. Some embodiments have a handle, a lumen, and a diverter valve. The distal end of the handle is adapted to connect with a sampling device and is in fluid communication with the lumen. There is a vacuum connection on the proximal end of the handle that is also in fluid communication with the lumen. A suction valve may desirably be located in the lumen to control the application of vacuum from the vacuum connection to the sampling device. The diverter valve directs the flow through the lumen such that a sample from the patient goes into a sputum trap when the trap is connected. The device may further have a saline port in fluid communication with the lumen, located distal to the suction valve, for rinsing the tube and diluting secretions. 1. A diverter valve for taking a sample from a patient comprising a valve body containing a valve having a first position in which a distal end of said valve is in fluid communication with a source of vacuum and a second position in which said distal end of said valve is in fluid communication with a sputum trap and said sputum trap is in fluid communication with said source of vacuum.29. The diverter valve of claim wherein said valve is moved from said first position to said second position by the connection of said sputum trap to said valve body.310. The diverter valve of claim wherein said valve is moved from said first position to said second position by the connection of said sputum trap to said valve body by twisting said valve body in a keyway in said sputum trap.49. The diverter valve of claim further comprising a loss prevention media is said sputum trap to prevent said sample from escaping.512. The diverter valve of claim wherein said loss prevention media is a nonwoven fabric , breathable film or combination thereof. The present application is a Divisional of U.S. patent application Ser. No. 13/268,009 filed on Oct. 7, 2011 and claims priority thereto.The present ...

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Номер записи: 17
03-04-2014 дата публикации

BIO-NANO-CHIPS FOR ON-SITE DRUG SCREENING

Номер: US20140094391A1
Автор: Christodoulides Nicolaos, Floriano Pierre N., McDevitt John T., Simmons Glennon
Принадлежит: William Marsh Rice University

A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid. 1. A disposable drug testing cartridge comprising a generally flat substrate having thereon individual bead sensors arranged in an array , wherein each bead sensor is a porous polymeric bead having a drug bound thereto , wherein said drug is selected from three or more of tetrahydrocannabinol (THC) , diazepam , oxazepan , nordiazepam , temazepam , D-amphetamine , methamphetamine , methadone , morphine , cocaine , 3 ,4-Methylenedioxyamphetamine (MDA) 3 ,4-Methylenedioxymethamphetamine (MDMA) and biological metabolites of same.2. The disposable drug testing cartridge of claim 1 , further comprising internal microfluidics on said substrate for carrying fluid to and from said bead sensors.3. The disposable drug testing cartridge of claim 2 , further comprising a sample entry port.4. The disposable drug testing cartridge of claim 3 , further comprising at least one reagent blister fluidly connected to said bead sensors.5. The disposable drug testing cartridge of claim 4 , further comprising at least one waste fluid chamber fluidly connected to and downstream of said bead sensors.6. The disposable drug testing cartridge of claim 4 , further comprising positive and negative control bead sensors and calibrator bead sensors.7. The disposable drug testing cartridge of claim 4 , wherein every drug bead sensor is present in said array in at least duplicate.8. The disposable drug testing cartridge of claim 4 , wherein every drug bead sensor is present in said array in at least ...

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Номер записи: 18
10-04-2014 дата публикации

BIOLOGICAL SAMPLE COLLECTION DEVICE

Номер: US20140100480A1
Автор: Pierce Alan Stuart, Potts Cheryl Louise, Stubbs Simon Laurence John, Treharne David Gwyn
Принадлежит:

Biological samples, such as saliva, are commonly collected on a swab and subsequently transferred to an absorbent storage medium. Embodiments of the present invention provide a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter. This provides an improved means of collecting a biological sample. 1. A biological sample collection device , comprising:a collection portion carrying a biological sample collection medium; and the collection portion being movably connected to the body portion, whereby the biological sample collection device is capable of being configured according to a first configuration and according to a second, different, configuration, wherein:', 'in said first configuration, the collection portion is at a first position spatially separated from the body portion for collecting a biological sample on the biological sample collection medium; and', 'in said second configuration, the collection portion is at a second position at least partly between the sample storage medium holding portion and the sample transfer means, and the sample transfer means is operable to apply a force to the collection portion, whereby said collection portion is compelled towards said holding position so that, when the storage medium holding portion holds a biological sample storage medium, the biological sample collection medium is ...

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Номер записи: 19
06-01-2022 дата публикации

METHODS AND DEVICES FOR COLLECTION OF EXHALED AEROSOLS

Номер: US20220000391A1
Автор: Han Jian, Pan Wenjing
Принадлежит:

The present disclosure relates to methods and devices for the collection of exhaled aerosols. In some embodiments, the device disclosed herein comprises a cup and an attachable lid, wherein the cup has a conical base and the lid includes a pipette access port with a removable cap and a sealed buffer reservoir. In some embodiments, the method for a subject to collect exhaled aerosols disclosed herein comprises the steps of placing a collection cup against the subject's mouth, the subject coughing into the collection cup at least once, immediately closing the device by reattached a lid to the collection cup, placing the collection cup in a transport bag, and providing the transport bag to a processor. The processor can then incubate the transport bag containing the collection cup, add buffer to the collection cup to rinse and suspend any collected exhaled aerosols, and then extract the buffer containing the exhaled aerosols either for storage or for immediate amplification and sequencing for the detection of pathogens. 1. A device for the collection of exhaled aerosols comprising:a collection cup, wherein the exterior base of the collection cup is flat; anda lid, wherein the lid comprises a port that forms a channel through the lid and wherein the lid is configured to attach to the collection cup.2. The device of claim 1 , wherein the device is cylindrical.3. The device of claim 1 , wherein the interior base of the collection cup is conical claim 1 , wherein the interior base narrows as it approaches the base of the collection cup.4. The device of claim 1 , wherein the collection cup and lid are threaded to allow the lid to screw onto and unscrew from the rim of the collection cup.5. The device of claim 1 , wherein the port is circular and the channel is cylindrical.6. The device of claim 1 , wherein the port and the channel are hexagonal.7. The device of claim 1 , wherein the port and the channel are approximately 25 mm in diameter.8. The device of claim 1 , wherein ...

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Номер записи: 20
06-01-2022 дата публикации

SYSTEMS AND METHODS FOR DETECTING COGNITIVE DISEASES AND IMPAIRMENTS IN HUMANS

Номер: US20220000414A1
Автор: Lednev Igor, Ralbovsky Nicole
Принадлежит:

Systems and methods for detecting a cognitive diseases and/or impairments in humans are disclosed. The method may include providing a saliva sample from a human subject, and subjecting at least a portion of the saliva sample to a spectroscopic analysis to produce a sample spectroscopic signature. The method may also include analyzing the produced sample spectroscopic signature using a predetermined statistical model. The predetermined statistical model may be based on spectroscopic signatures for a plurality modeling samples, and the spectroscopic signatures for each of the plurality of modeling samples may be associated with one of a plurality of predetermined cognitive categories. Additionally, the method may include correlating the produced sample spectroscopic signature with one of the plurality of predetermined cognitive categories based on the spectroscopic signatures for each of the plurality of modeling samples of the predetermined statistical model. 1. A method for detecting a cognitive disease , the method comprising:providing a saliva sample from a human subject;subjecting at least a portion of the saliva sample to a spectroscopic analysis to produce a sample spectroscopic signature for the saliva sample;analyzing the produced sample spectroscopic signature using a predetermined statistical model, the predetermined statistical model based on spectroscopic signatures for a plurality modeling samples,wherein the spectroscopic signatures for each of the plurality of modeling samples are associated with one of a plurality of predetermined cognitive categories; andcorrelating the produced sample spectroscopic signature with one of the plurality of predetermined cognitive categories based on the spectroscopic signatures for each of the plurality of modeling samples of the predetermined statistical model.2. The method of claim 1 , where the plurality of predetermined cognitive categories include:a cognitive healthy class;an Alzheimer's disease class; anda mild ...

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Номер записи: 21
06-01-2022 дата публикации

COLLECTION AND TREATMENT OF A BIOFLUID SAMPLE

Номер: US20220000457A1
Автор: FABRIZIO Eve F., HENDRIX Pamela, HOLLER Kraig, KEYGHOBAD Seyamak, KLEIN Jessica, PATEL Bindi, ZITEK Trevor
Принадлежит:

A system can facilitate pre-treatment a biofluid sample for various applications for monitoring and/or tracking a subject's health. The system includes a sample collection component that can collect the biofluid sample. The system also includes a mixing component that includes a media with a material. Upon adding the biofluid sample to the mixing component, the biofluid sample mixes with the media. The system also includes a filter component that can filter the media from the biofluid sample. After the media is filtered from the biofluid sample, the biofluid sample can be provided to an analyte analysis application. 1. A method comprising:adding a biofluid sample to a media comprising a carbon-containing material, wherein the biofluid sample comprises a liquid, an analyte and at least one contaminant;mixing the biofluid sample and the media to reduce a concentration of the at least one contaminant in the biofluid sample;filtering the media from the biofluid sample,wherein the mixing and/or the filtering uses a mechanical mechanism; andproviding the biofluid sample for analysis.2. The method of claim 1 , wherein the analysis comprises the detecting the analyte in the biofluid sample.3. The method of claim 1 , wherein the carbon-containing material eliminates at least a portion of the at least one contaminant in the biofluid sample.4. The method of claim 1 , wherein the carbon-containing material comprises activated charcoal claim 1 , activated carbon claim 1 , carbon black claim 1 , graphite claim 1 , graphene claim 1 , oxidized graphene claim 1 , and/or reduced graphene.5. The method of claim 1 , further comprising collecting the biofluid sample claim 1 , wherein the biofluid sample comprises a bodily fluid.6. The method of claim 5 , wherein the bodily fluid comprises tears claim 5 , saliva claim 5 , urine claim 5 , serum claim 5 , plasma claim 5 , and/or blood.7. The method of claim 1 , wherein the analysis comprises detecting an amount of the analyte in the ...

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Номер записи: 22
04-01-2018 дата публикации

ORAL PH AND BUFFERING CAPACITY MODIFIERS

Номер: US20180000392A1
Автор: Cao Densen, Jensen Steven D
Принадлежит: CAO GROUP, INC.

Example embodiments of the present invention include various compositions that include a pH modifier composition and/or a buffering capacity modifier composition. In some examples, the pH modifier compositions include a dose of pH modifier to raise the pH in a patient's mouth from about 1 to about 2 pH levels. The compositions are then incorporated into various confections for oral ingestion or application that allow a patient to easily use the composition with the pH and/or buffering capacity modifiers. For example, compositions with the pH and/or buffering capacity modifiers can be incorporated within chewing gum, tablets, lozenges, breath strips, hard candy, oral sprays, and other confections. Another embodiment of the invention includes a testing device to test the pH and buffering capacity within a patient's mouth. 1. A dental treatment system for directly controlling the pH environment within a patient's oral cavity , comprising: a testing strip;', "a pH testing pad attached to the testing strip and configured to test the pH level of a patient's saliva; and", 'a buffering capacity testing pad attached to the testing strip and configured to test the buffering capacity of a patients saliva; and, 'a testing device, comprising an oral pH modifier composition; and', 'an oral buffering capacity modifier composition,, 'a delivery device, comprisingwherein the testing device is used to determine the dosage of the delivery device such that the patient can customize the use of the delivery device to control the pH within the patient's oral cavity.2. The dental treatment system recited in claim 1 , wherein the delivery device is in the form of a confection.3. The dental treatment system recited in claim 2 , wherein the buffering capacity modifier composition comprises calcium ascorbate.4. The dental treatment system recited in claim 3 , wherein the calcium ascorbate has a weight percentage within the range of about 1% to about 10% of the overall weight of the confection. ...

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Номер записи: 23
05-01-2017 дата публикации

DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION

Номер: US20170001191A1
Автор: ANDREWS Stephen, BIADILLAH Youssef, BRIDEN Chris, LEEDLE Melvin J., PRIESS Benjamin Cooper, Rutter Bryce G., SUNDY Jonathan
Принадлежит:

Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described. 140-. (canceled)41. A bodily fluid sample collection device for the collection of naturally expressed bodily fluids , comprising:a cap, and a tube having a mouth, wherein:the cap is engageable with the tube so as to close the mouth of the tube, a first cap portion defining at least a portion of a chamber for containing a reagent, and', 'a second cap portion defining a closure for closing an aperture communicating with the chamber,', 'the second cap portion being configured, in use responsive to fitting the cap to the tube, to disengage from the first cap portion, and descend at least partly into the tube, and, 'the cap comprisingthe tube defines at least a portion of a sample collection space for receiving the naturally expressed bodily fluid.421. The device of claim , wherein the first and second cap portions are relatively movable with respect to each other , the first and second cap portions being configured such that , responsive to engagement of the cap on the tube , one of the cap portions is caused to move relative to the other cap portion to ...

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Номер записи: 24
13-01-2022 дата публикации

NASOPHARYNGEAL ASPIRATE COLLECTION DEVICE

Номер: US20220008045A1
Автор: HAUGHEY John, Mangan Wilma
Принадлежит:

Methods and systems directed towards a single use nasopharyngeal aspirate collection device comprising, a reservoir capable of contracting and expanding in a lineal motion at least one time, a nozzle comprising an at least one orifice at a distal end of the nozzle, a fastening means capable of coupling a proximal end of the reservoir with a proximal end of the nozzle, a guard disposed about a portion of an outer wall of the reservoir adjacent to the proximal end of the reservoir, and an internal cavity extending from the reservoir through the nozzle. 1. A nasopharyngeal aspirate collection device comprising:a reservoir capable of contracting and expanding in a lineal motion at least one time;a nozzle comprising an at least one orifice at a distal end of the nozzle;a fastening means capable of coupling a proximal end of the reservoir with a proximal end of the nozzle;a guard disposed about a portion of an outer wall of the reservoir adjacent to the proximal end of the reservoir; andan internal cavity extending from the reservoir through the nozzle.2. The apparatus of claim 1 , wherein the nasopharyngeal aspirate collection device is a single use device.3. The apparatus of claim 1 , further comprising a cap.4. The apparatus of claim 1 , wherein the distal end of the nozzle comprises three orifices; wherein two orifices are crescent-shaped and border the third orifice which is disposed between the two crescent-shaped orifices.5. The apparatus of claim 1 , wherein the distal end of the nozzle comprises a half-domed shape which extends inward toward the proximal end of the nozzle.6. The apparatus of claim 5 , further comprising a cap with a half-domed shape which corresponds to the half-domed shape of the nozzle when the cap is placed over the nozzle.7. The apparatus of claim 1 , wherein the reservoir is a single reservoir which contains aspiration fluid before use and a collected sample after use.8. The apparatus of claim 1 , wherein the nozzle comprises at least two ...

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Номер записи: 25
02-01-2020 дата публикации

NON-INVASIVE BRAIN INJURY DIAGNOSTIC DEVICE

Номер: US20200003772A1
Автор: HAREL Adrian, VÄLIMAA Lasse
Принадлежит:

Disclosed is a device for conducting a non-invasive diagnostic test in a subject suspected of suffering brain injury. The device for diagnosing a brain injury in a subject includes a probe of a porous matrix, an indicator formulation disposed on the porous matrix and includes at least one lectin and/or antibody capable of selectively binding to a glycan-based biomarker indicative of brain injury in a sample, and a visually detectable label; and a handle in communication with the probe, wherein at least one of the lectin and/or antibody and/or the visually detectable label is immobilized in and/or on a detection zone in the porous matrix, and the visually detectable label develops a color intensity level and becomes visible upon a binding event of the glycan-based biomarker to the lectin and/or antibody. Also provided is a method for using the device described below and methods for producing the same. 124-. (canceled)25. A device for diagnosing a brain injury in a subject , comprising:a probe, said probe comprises a porous matrix; andan indicator formulation disposed in and/or on said porous matrix and comprises at least one glycan-based biomarker binding reagent for selectively binding to a glycan-based biomarker in a sample, and a first visually detectable label;wherein:at least one of said glycan-based biomarker binding reagent and/or said first visually detectable label is immobilized in and/or on a detection zone in said porous matrix;said glycan-based biomarker is indicative of brain injury;said first visually detectable label develops a color and becomes visible upon a binding event of said glycan-based biomarker to said glycan-based biomarker binding reagent; andsaid binding event is effected by contacting said sample with said probe.26. The device of claim 25 , wherein said glycan-based biomarker binding reagent is a lectin and/or an antibody.27. The device of claim 25 , wherein said first visually detectable label is attached to said glycan-based biomarker ...

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Номер записи: 26
20-01-2022 дата публикации

SPECIMEN COLLECTION AND STORAGE FOR POOL TESTING AND SIMILAR

Номер: US20220015746A1
Автор: CHERIF Alhaji, Garbaccio Mia G., Grobe Nadja, KOTANKO PETER, Wang Xiaoling
Принадлежит:

The present teachings generally include devices, systems, kits, and methods for collecting, storing, and transporting specimens, e.g., in the context of pool testing. For example, the present teachings may include a compound swab featuring a first swab and a second swab, where the first swab can be detached for pool testing and the second swab can be preserved for testing based on results of the pool test. The present teachings may also or instead include a container having a separator structurally configured to separate swabs of a compound swab. Further, the present teachings may include a swab having a suction enhancer to promote the capture of a specimen on a collection tip thereof. The present teachings may also or instead include a receptacle that can house a plurality of swabs and sever at least a portion of the collections tips thereof, e.g., for pool testing. 1. A device for collecting a specimen for testing , the device comprising:a first swab including a first shaft and a first collection tip disposed on a first end of the first shaft, the first collection tip structurally configured to acquire a first portion of a specimen thereon;a second swab including a second shaft and a second collection tip disposed on a first end of the second shaft, the second collection tip structurally configured to acquire a second portion of the specimen thereon; anda common shaft engaged with a second end the first shaft and a second end of the second shaft, wherein engagement of the second ends of each of the first shaft and the second shaft to the common shaft define a first breakpoint structurally configured for separating one or more of the first swab and the second swab from the common shaft.2. The device of claim 1 , wherein claim 1 , after acquisition of the specimen using the device claim 1 , the first swab is used in a pool testing procedure claim 1 , and wherein the second swab is preserved for testing of the specimen based on results of the pool testing procedure.3 ...

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Номер записи: 27
12-01-2017 дата публикации

CORRELATION OF SALIVA FLOW-RATE AND ORAL DRYNESS IN HYPERURICEMIA

Номер: US20170007172A1
Автор: Akbar ZAHIR Hussain M, Shaikh-Omar Osama Abdulrahman
Принадлежит:

Hyperuricemia has been studied extensively. However studies on salivary flow rate (SFR; ml/min) in unstimulated saliva (USS) and stimulated saliva (SS) conditions and oral dryness (OD) in subjects with hyperuricemia (HUS) have never been conducted. Current studies showed significantly decreased values in presence of OD (ODP) compared to absence of OD (ODA) in USS both for NUS (normouricemic subjects; p=0.0001) and HUS (p=0.0170). Furthermore, OD comparisons gave significantly decreased values in ODP compared to ODA in SS both for NUS (p=0.0049) and HUS (p=0.0444). In view of the significance in hyperuricemic subjects the “flow rate of unstimulated saliva (USS) and stimulated saliva (SS) decreases significantly in hyperuricemic subjects with oral dryness present (ODP)”. Conclusively, it is suggested that the salivary digestion affected in hyperuricemia can be diagnosed by investigating the salivary composition and flow rate. 1. A method to identify hyperuricemia in a subject , the method comprising:estimating a uric acid level of the subject in need of diagnosis for the hyperuricemia, the uric acid level being measured in a saliva or blood;categorizing the subject as hyperuricemic when the uric acid level is above 420 micromol/l and as normouricemic when the uric acid level is below 420 micromol/l;evaluating an absence or a presence of oral dryness of the subject;collecting an unsimulated saliva and a simulated saliva of the subject;estimating a flow-rate of the unsimulated saliva and a simulated saliva, the flow-rate being estimated based on the collected the unsimulated saliva and the simulated saliva; andcomparing oral dryness, the flow rate of an unsimulated saliva and a simulated saliva, and the hyperurecimia in a subject to diagnose hyperuricemic state in a subject.2. The method of claim 1 , further comprising evaluating salivary composition for diagnosis of the subject with or without hyperuricemia.3. The method of claim 1 , wherein oral dryness being ...

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Номер записи: 28
12-01-2017 дата публикации

SYSTEM FOR SALIVA COLLECTION

Номер: US20170007215A1
Автор: PODOLY Erez
Принадлежит: SALVME, INC.

Disclosed herein are portable handheld devices for saliva collection for daily monitoring of salivary biomarkers of physiological conditions, the device comprising: a handheld handle comprising a saliva collector, the saliva collector comprising: a suction tip; a bi-directional pump electrically configurable for pumping towards two opposite directions; a saliva reservoir; a valve; a water reservoir, the water reservoir comprising an external filling lid; a reversible fluidic connection configurable in a connected and disconnected position; and a base accommodating the handheld handle, the base configurable to fluidly communicate with the handheld handle through at least the reversible fluidic connection, wherein the valve is electrically configured to allow fluid communication directly between at least two selected from: the saliva reservoir, the water reservoir, and the reversible fluidic connection, and wherein the bi-directional pump is electrically configurable to allow fluid communication directly between the suction tip and the saliva reservoir. 139-. (canceled)40. A portable handheld device for tooth brushing and saliva collection for daily monitoring of salivary biomarkers of physiological conditions of a subject , the device comprising: i) a suction tip;', 'ii) a bi-directional pump electrically configurable for pumping towards two opposite directions;', 'iii) a saliva reservoir;', 'iv) a valve;', 'v) a water reservoir, the water reservoir comprising an external filling lid;', 'vi) a reversible fluidic connection configurable in a connected position and a disconnected position; and, 'a) a handheld handle comprising a saliva collector, the saliva collector comprisingb) a base accommodating the handheld handle, the base configurable to fluidly communicate with the handheld handle through at least the reversible fluidic connection, wherein the valve is electrically configured to allow fluid communication directly between at least two elements selected from: ...

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Номер записи: 29
14-01-2021 дата публикации

Saliva test strip and method

Номер: US20210007646A1
Автор: Alan Dayvault LUTHER, Chathurika Darshani Abeyrathne, Duc Hau Huynh, Duc Phuong NGUYEN, Efstratios Skafidas, Gursharan Chana, Hsien MING, Michael ERLICHSTER, Michael Luther, Thanh Cong NGUYEN, Ting Ting Lee, Trevor John Kilpatrick, You Liang
Принадлежит: MX3 Diagnostics Inc

A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.

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Номер записи: 30
11-01-2018 дата публикации

Bodily fluids specimen collection device

Номер: US20180008238A1
Автор: Susan D. Paige
Принадлежит: Individual

The invention is a bodily fluids sample collection device comprising a planar elastic elongated frame member and has frame sides concurrently angling inward to a cup securing region, thereby having an increasingly narrowing frame width to a semi-circular cup holding portion, adapted to securely receive a bodily fluids sample cup disposed in an upright position for receiving a bodily fluids sample from a patient, and flexibly adapted for easy placement and release of the bodily fluids sample cup. The toilet bowl or the toilet seat freely supports the device, and handles enables the patient to grasp the device without touching the toilet seat or the toilet bowl, and away from the sample cup of differing sizes. The device may have a collection handle, enabling the patient to grasp the device away from the bodily fluids sample cup.

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Номер записи: 31
11-01-2018 дата публикации

DEVICE FOR ASSAYING ANALYTES IN BODILY FLUIDS

Номер: US20180008240A1
Автор: Engel Matthias W., Johnson Paul, Wilson Leslie
Принадлежит: EXPRESS DIAGNOSTICS INT'L, INC.

A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. The sampling element can include an indicator strip for determining whether the amount of liquid sample sufficient for carrying out an assay. 1. A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid , comprising:a container for receiving a sample of body fluid, with an interior that is delimited by a base and a wall,at least one test strip with an absorbent section and with reagents for determining the presence and/or quantity of one or more analytes in the sample of body fluid, the test strip secured within the containers at the wallan elongate sampling element with a first and a second end, has an absorbent sampler at one of the first and second ends that takes up the sample of body fluid, and wherein said absorbent sample is insertable into the container assembly for transferring the sample of body fluid into the container,wherein the container conveys the sample of body fluid from the sampler, by compression thereof in the container, to the at least one test strip.wherein the elongate sampling element includes an indicator for indication of the presence of the liquid sample of sufficient quantity for the carrying out of the assay for determining the presence of the one or more analytes in the sample.2. The ...

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Номер записи: 32
14-01-2021 дата публикации

TRACE AMOUNT LIQUID SAMPLE COLLECTOR

Номер: US20210007720A1
Автор: Ito Narushi, Katayama Norikazu
Принадлежит:

The objective of the present invention is to provide a liquid sample collector capable of collecting a trace amount of a specimen such as a tear safely and in an adequate amount. This trace amount liquid sample collector is characterized in that: the liquid sample collector is provided with a main body and a first absorbent body; the main body has at least one open end portion; the main body includes a hydrophobic material having elasticity; the first absorbent body is disposed at least partially inside the main body; the first absorbent body includes a water-absorbent material; and the first absorbent body is disposed in such a way as to be capable of coming into contact with the outside by way of the at least one open end portion of the main body. 1. A trace-amount liquid sample collector , comprising:a main body and a first absorbent body,wherein the main body has at least one open end,wherein the main body includes an elastic hydrophobic material,wherein the first absorbent body is at least partially disposed inside the main body,wherein the first absorbent body includes a water-absorbing material, andwherein the first absorbent body is disposed so as to contact the outside via the at least one open end of the main body,.wherein the collector has a flow path leading from the open end to the inside of the main body,wherein the first absorbent body is disposed in the flow path,wherein the width of the first absorbent body is designed to be smaller than the width of the flow path, andwherein it is designed to allow air to pass between the open end and the inside of the main body through a gap between the flow path and the first absorbent body.2. The trace-amount liquid sample collector of claim 1 ,wherein by contacting the absorbent body with a trace sample, the trace sample is absorbed and retained in the absorbent body.3. The trace-amount liquid sample collector of claim 2 ,wherein by applying a pressure to the main body, then bringing the absorbent body into ...

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Номер записи: 33
14-01-2021 дата публикации

SALIVA ASSESSING METHOD, DEVICE, AND SYSTEM

Номер: US20210007721A1
Автор: Beck Kent F., Donovan Grant J., Malmstrom James A., Miles Scott D., Patterson Ryan C., Stern Jeffrey A.
Принадлежит:

Various embodiments of a swab device, system, and method are provided for measuring and assessing saliva flow in the mouth of a person. In one embodiment, a system includes a swab device and a measuring device. The swab device includes a handle portion and a swab portion, the handle portion being elongated to extend between a proximal end and a distal end. The swab portion is coupled to a distal portion of the handle portion and is sized and configured to collect saliva from the mouth. The measuring device is sized and configured to measure an amount of the saliva collected with the swab portion, the measuring device including a nesting portion integrated therewith. Such nesting portion of the measuring device is sized and configured to receive the proximal end of the handle portion of the swab device to measure the saliva collected therewith. 1. A method for measuring saliva flow in a mouth of a person , comprising:clearing excess saliva from the mouth;inserting a swab into the mouth for a first predetermined period of time ranging between about 1 second and about 20 seconds; andmeasuring an amount of saliva captured by the swab by positioning the swab on a measuring device.2. The method according to claim 1 , further comprising determining whether the measured amount of saliva is below a standard healthy saliva amount.3. The method according to claim 1 , further comprising:maintaining the mouth in a closed position for a second predetermined period of time ranging between about 3 second and about 90 seconds;inserting a second swab into the mouth for a third predetermined period of time ranging between about 1 second and about 20 seconds; andmeasuring an amount of saliva captured by the second swab by positioning the second swab on the measuring device.4. A method for measuring saliva flow in a mouth of a person claim 1 , comprising:clearing excess saliva from the mouth;maintaining the mouth in a closed position for a first predetermined period of time ranging ...

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Номер записи: 34
27-01-2022 дата публикации

MULTI-STAGE ORAL-FLUID TESTING DEVICE

Номер: US20220023858A1
Автор: ALTENDORF Wayde J., BAILEY Todd, FULLER Kevin S.
Принадлежит:

In an embodiment, the claimed invention includes an oral-fluid collection and testing device that. is simple to operate. The device includes a body assembly and a cap assembly that are easy to handle by a user. A collection sponge projects from an end of the body assembly for absorbing the oral fluid of a donor, A cap assembly is easily aligned with the body assembly by way of visual alignment indicators on both the body and the cap. Once the cap is aligned with the body, a user simply pushes the cap onto the ‘body, which causes a first stage fluid, flow. More specifically, a buffer fluid is released from the cap and mixes with the oral fluid collected on the sponge—After waiting a short time* the cap is rotated, then pushed again, causing a second-stage fluid flow in which the sponge is compressed such that the buffer fluid/oral fluid exits the sponge and flows toward a. pair of test strips. A user can then easily view the test results by observing a visual indication, such as a color change of the test strips through a viewing window. 19-. (canceled)10. A testing device for collecting and testing a bodily fluid for substances , the testing device comprising: a cap having a first end and a second end opposite the first end, and configured to receive a portion of a body assembly at the second end, the cap defining a first cap cavity at the first end and a second cap cavity at the second end;', 'a fluid container disposed in the first cavity, wherein the fluid container includes a sealing membrane and contains a mixing fluid for mixing with a bodily fluid; and', 'a plunger with an end wall movably disposed in the second cavity, wherein the plunger has a first position and a second position, and wherein at the first position, the end wall of the plunger is configured to not compress a collection sponge attached to the body assembly when received by the cap., 'a cap assembly, including11. The testing device of claim 10 , wherein the plunger is not moved and stable at ...

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Номер записи: 35
08-01-2015 дата публикации

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

Номер: US20150011911A1
Автор: BULLINGTON Gregory, GAW Shan E., MIAZGA Jay M., Patton Richard G.
Принадлежит:

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139-. (canceled)40. A method of obtaining a bodily-fluid sample from a patient using a parenteral sampling device , the method comprising:establishing fluid communication between the patient and an inlet port of the parenteral sampling device;disposing a flow control mechanism in a first configuration, the first configuration operable to allow bodily-fluid to flow from the patient, through the inlet port, and into a fluid reservoir;moving an actuator a first distance to form a negative pressure in the fluid reservoir, the actuator including a seal member that defines a portion of the fluid reservoir such that the moving of the actuator the first distance moves the seal member from a first position toward a second position to form the negative pressure in the fluid reservoir;receiving a first volume of bodily-fluid into the fluid reservoir while the flow control mechanism is in the first configuration;moving the actuator a second distance, after the first volume of bodily-fluid has been received into the fluid reservoir, to move the flow control mechanism from the first configuration to a ...

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Номер записи: 36
10-01-2019 дата публикации

SALIVA COLLECTION, PROCESSING, STABILIZATION, AND STORAGE METHOD

Номер: US20190010538A1
Автор: LIAO Wei, Wong David T.
Принадлежит:

Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness. 1. A method for stabilizing nucleic acid and protein samples isolated from a saliva sample , the method comprising:a) collecting a saliva sample from a subject;b) filtering the saliva sample to produce a filtered sample that is free of cells;c) collecting the filtered sample in at least a first and a second receiving device;d) adding an alcohol solution to the first receiving device to produce an alcohol-containing filtered sample comprising a protein sample, with the proviso that alcohol is not added to the second receiving device to produce an alcohol-free filtered sample comprising a nucleic acid sample; wherein the protein sample and the nucleic acid sample are stabilized for at least 3 days when stored at 25 degrees Celsius; ande) performing an analysis on the filtered sample collected in the first and second receiving devices comprising one or more of: a protein analysis on the alcohol-containing filtered sample or a nucleic acid analysis on the alcohol-free filtered sample.2. The method of claim 1 , wherein the nucleic acid is DNA.3. The method of claim 1 , wherein the nucleic acid analysis is polymerase chain reaction (PCR).4. The method of claim 1 , wherein the nucleic acid is RNA.5. The method of claim 4 , wherein the nucleic acid analysis is RT-PCR.6. The ...

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Номер записи: 37
10-01-2019 дата публикации

COLLECTION DEVICE AND MATERIAL

Номер: US20190011331A1
Автор: Dixon Todd, Dube Paul, KIM Yong K., Lewis Armand F., Templet Timothy, Young Terry
Принадлежит:

Swabs, materials, and methods of making same, include randomly arranged sea-island bicomponent fibers. According to certain embodiments, swabs and methods of using such swabs are provided so as to collect and release a biological sample comprising a flock fiber tipped applicator wherein the flock fibers are sea-island bicomponent fibers attached to an end portion of the applicator with an adhesive selected from the group consisting of a photocurable acrylic adhesive and a polyurethane adhesive, the bicomponent fibers being structurally stable in water and the sea component of the bicomponent flock fibers being intact. 1. A swab constructed to collect and release a biological sample comprising a flock fiber tipped applicator comprised of:an applicator; andflock fibers attached to the applicator, whereinthe flock fibers are sea-island bicomponent fibers attached to an end portion of said applicator with an adhesive selected from the group consisting of a photocurable acrylic adhesive and a polyurethane adhesive, and whereinthe bicomponent fibers comprise a first polyester sea material and a second polyester island material, and whereinthe first polyester sea material has a lower melting point and a greater solubility than the second polyester sea material.2. The swab of wherein the first polyester sea material has a greater solubility in alkaline solution of sodium hydroxide as compared to the second polyester island material.3. The swab of wherein the first polyester sea material has greater solubility in an alkaline solution of sodium hydroxide solution containing about 5% to about 50% by weight sodium hydroxide in water as compared to the second polyester island material.4. The swab of wherein the first polyester sea material has greater solubility in an alkaline solution of about 10% by weight sodium hydroxide in water as compared to the second polyester island material.5. The swab of wherein the first polyester sea material has greater solubility in a heated ...

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Номер записи: 38
10-01-2019 дата публикации

COLLECTION DEVICE AND MATERIAL

Номер: US20190011332A1
Автор: Dixon Todd, Dube Paul, KIM Yong K., Lewis Armand F., Templet Timothy, Young Terry
Принадлежит:

Swabs, materials and methods of making the same include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. According to certain embodiments, swabs are provide which include an applicator, and sea-island bicomponent fibers attached to the applicator, wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 45% or less from said ends, and wherein the bicomponent fibers comprise 10-3000 island parts per fiber. 1. A swab constructed to collect and release a biological sample comprising a liquid , wherein the swab comprises:an applicator; andsea-island bicomponent fibers attached to the applicator, whereinat least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 45% or less from said ends.2. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 10% or less from said ends.3. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 15% or less from said ends.4. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 20% or less from said ends.5. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 25% or less from said ends.6. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 30% or less from said ends.7. The swab of wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a ...

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Номер записи: 39
19-01-2017 дата публикации

MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF

Номер: US20170014064A1
Автор: Burd Tammy, Frenzel Gary, Gibbons Ian, Holmes Elizabeth A., Nugent Anthony Joseph
Принадлежит:

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. 158-. (canceled)59. A method of measuring a volume of a sample of a biological fluid , comprising:a. reacting a known quantity of a control analyte in said sample with a reagent to yield a detectable signal indicative of the quantity of the control analyte; andb. comparing said detectable signal with an expected detectable signal, wherein the expected signal is indicative of an expected volume of the sample, and wherein said comparison provides a measurement of said volume of said sample being measured.60. The method of claim 59 , wherein the control analyte is normally not present in said sample in a detectable amount.61. The method of further comprising verifying the volume of said sample when the measurement of the volume of the sample is within about 50% of the expected volume of the sample.62. The method of further comprising:a. reacting a bodily fluid sample containing a target analyte with a reagent to yield a detectable signal indicative of the target analyte; andb. measuring the quantity of the target analyte in the bodily fluid sample based on of said detectable signal indicative of the target analyte and the measurement of said volume of said liquid sample.63. The method of claim 59 , wherein the liquid sample and the bodily fluid sample are the same sample.64. The method of claim 59 , wherein the control analyte does not react with the target analyte in the bodily fluid sample.65. The method of claim 59 , wherein the liquid sample and the bodily fluid sample are different liquid samples.66. The method of claim 59 , wherein the control analyte is selected from the group consisting of: albumin claim 59 , fluorescein ...

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Номер записи: 40
21-01-2016 дата публикации

ORAL HEALTH MONITORING AND MANAGEMENT

Номер: US20160015321A1
Автор: HASHEMIAN Shervin Tony
Принадлежит:

Innovative oral health monitoring technologies, which may be embodied in various apparatuses, systems, and methods, provide enhanced patient sample pH testing and other health data. The technologies may involve an oral health monitoring apparatus, which may include a mouthpiece housing, a pH sensor, and a wireless communication interface. The mouthpiece housing may be fitted to a mouth of a patient and may, by way of the pH sensor, capture saliva pH measurements. The technologies may involve wirelessly transmitting the measurements to a server for health condition correlation analyses, visual report generation, and subsequent display on a user device. 1. An oral health monitoring apparatus , the apparatus comprising:a mouthpiece housing;a pH sensor that captures a plurality of pH measurements of saliva in a mouth of a patient; anda wireless communication interface that sends the captured plurality of pH measurements over a wireless communication network to a server.2. The apparatus of claim 1 , wherein the mouthpiece housing is fitted to the mouth of the patient.3. The apparatus of claim 1 , wherein the pH sensor is disposed in the mouthpiece housing.4. The apparatus of claim 1 , wherein the wireless communication interface is disposed in the mouthpiece housing.5. The apparatus of claim 1 , wherein the received pH measurements are captured over a predetermined time interval.6. An oral health monitoring system claim 1 , the system comprising:a monitoring device that captures a plurality of pH measurements of saliva in a mouth of a patient; anda server that receives the pH measurements from the monitoring device over a wireless communication network.7. The system of claim 6 , wherein the server generates a visual display of the pH measurements over time.8. The system of claim 7 , wherein the server transmits the visual display of the PH measurements over time to a mobile device of a user.9. The system of claim 6 , wherein the monitoring device captures the plurality ...

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Номер записи: 41
21-01-2016 дата публикации

Biological Sample Collection Device

Номер: US20160015370A1
Автор: Pierce Alan Stuart, Potts Cheryl Louise, Stubbs Simon Laurence John, Treharne David Gwyn
Принадлежит:

Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.

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Номер записи: 42
03-02-2022 дата публикации

METHOD OF MITIGATION OF DEATH FROM EPILEPTIC SEIZURES

Номер: US20220034911A1
Автор: Vega Jose
Принадлежит:

A method for determining the severity of a mammalian dive response (MDR) triggered during a patient's seizure that includes the following steps: (1) collecting an ictal specimen, the ictal specimen being a saliva or any other secretion from the mouth of the patient when the patient is in a peri-ictal period; (2) analyzing the ictal specimen to measure a level of a specimen marker, the specimen marker being a cellular or non-cellular biological component; and (3) determining the severity of the MDR or other autonomic reflex based on the level of the specimen marker. 1. A method for determining the severity of a mammalian dive response (MDR) triggered during a patient's seizure comprising the following steps:(1) collecting an ictal specimen, the ictal specimen being a saliva or any other secretion from the nose or mouth of the patient when the patient is in a peri-ictal period;(2) analyzing the ictal specimen to measure a level of a specimen marker, the specimen marker being a cellular or non-cellular biological component; and(3) determining the severity of the MDR based on the level of the specimen marker.2. The method of claim 1 , wherein step (2) comprisescollecting a reference specimen, the reference specimen being a saliva or any other secretion from the nose or mouth of the patient when the patient is not having a seizure or from a pool of healthy age-appropriate seizure-free volunteers; andanalyzing the ictal specimen to measure the level of the specimen marker;analyzing the reference specimen to measure a level of the specimen marker; andcomparing the level of the specimen marker in the ictal specimen with the level of the specimen marker in the reference specimen.3. The method of claim 2 , wherein the ictal specimen and the reference specimen are a tissue claim 2 , a fluid claim 2 , a cell claim 2 , an electrolyte claim 2 , or a molecule found in or around a respiratory system.4. The method of claim 3 , wherein the ictal specimen and reference specimen are a ...

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Номер записи: 43
17-01-2019 дата публикации

SCREENING DEVICE FOR ANALYSIS OF BODILY FLUIDS

Номер: US20190015829A1
Автор: ALTENDORF Wayde J., FULLER Kevin S.
Принадлежит:

A screening device for testing saliva for the presence of certain constituents. The device has a D-shaped profile when viewed from above and includes a first wall with planar front face through which all of the test strips are viewed and a curved rear second wall. The device also includes a floor surface with an uppermost portion extending from the rear wall to a lowermost portion at the first wall such that saliva squeezed from a sampler at a location between the upper most portion and the lowermost portion flows downwardly to the test strips. 135-. (canceled)36. A device for testing saliva , the device comprising:a cup comprising an outer planar forward wall connecting to an outer curved rearward wall providing a D-shaped outer perimeter of the device when viewed from below, the outer planar forward wall providing the straight portion of the “D” and the outer curved rearward wall providing the remainder of the “D”, the cup having a lower edge that registers the cup in an upright position, an inclined plate traversing continuously upwardly and rearwardly between the planar forward wall and the curved rearward wall, the inclined plate having a lowermost portion of the plate proximate the planar front wall and an uppermost portion of the inclined plate exclusively at the rearward wall and the inclined plate defining a cavity with a single lowermost extremity of the cavity positioned at the planar forward wall;a test strip holder positioned in the cavity adjacent the planar forward wall of said cup, a plurality of test strips positioned between the test strip holder and the forward wall, the plurality of test strips extending to the single lowermost extremity of the cavity and the plurality of test strips comprising all of the test strips of the device;a cap portion positioned at a top portion of the cup, the cap portion having a D-shaped outer perimeter when viewed from above, the D-shaped outer perimeter providing an outermost periphery of the device when viewed ...

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Номер записи: 44
19-01-2017 дата публикации

DEVICE FOR SAMPLE COLLECTION

Номер: US20170016807A1
Автор: ANDREWS Stephen, BIADILLAH Youssef
Принадлежит: ABOGEN, INC.

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery. 122-. (canceled)23. A solution for preserving cells in bodily fluid for further separation into cell types and downstream epigenetic analysis that allows for storage of cells in bodily fluid to retain their antigenicity and cellular architecture , the solution comprising at least one chemical fixing agent and at least one protease inhibitor , buffered at a pH from about 6.4 to about 8.4.24. The solution according to claim 23 , further comprising one or more of at least one antimicrobial agent and serum proteins from human and/or other animal species.25. The solution according to claim 23 , wherein the chemical fixing agent is selected from the group consisting of ...

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Номер записи: 45
17-01-2019 дата публикации

Direct specimen collection device and cassette

Номер: US20190017907A1
Автор: Jangbir Sangha
Принадлежит: Laboratory Corp of America Holdings

The present disclosure relates to a specimen collection device comprising ventilation means for drying a collected specimen. The device further comprises a cassette into which the specimen collected is secured to maintain evidentiary chain of cus tody requirements while providing unobstructed access to a collected specimen for automated analysis. Methods of using the device are also provided.

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Номер записи: 46
28-01-2016 дата публикации

DIAGNOSTIC TEST DEVICE WITH IMPROVED DISPLAY

Номер: US20160022225A1
Автор: Nazareth Albert R., Palmer Mathew, Romanoschi Ovieiu, Sanders Giles H.W., Snowden Timothy
Принадлежит:

The present disclosure relates to diagnostic test devices that provide enhanced communication to a user thereof through provision of improved digital display. The test device can include a test member, such as lateral flow assay test strip. The test device can further include an electronic communication circuit that can comprise a digital display element as well as a microcontroller. Other elements in the electronic communication circuit can include one or more sensor elements, an audio element, and one or more switching elements. The disclosure further relates to methods of providing indicia of operation of a test device that comprises steps for assembly of a diagnostic test device that includes an improved digital display. 1. A diagnostic test device comprising:a test member; andan electronic communication circuit adapted to provide one or more indicia of operation of the test member to a user;wherein the electronic communication circuit includes a color digital display.2. The diagnostic test device of claim 1 , wherein the color digital display comprises a plurality of color-variable pixels.3. The diagnostic test device of claim 1 , wherein the color digital display comprises one or more light emitting diode (LED).45-. (canceled)6. The diagnostic test device of claim 1 , wherein the color digital display comprises a liquid crystal display (LCD).710-. (canceled)11. The diagnostic test device of claim 6 , wherein the LCD comprises backlighting.12. The diagnostic test device of claim 1 , wherein the electronic communication circuit comprises a microcontroller.1323-. (canceled)24. The diagnostic test device of claim 1 , wherein the electronic communication circuit further includes an audio output component.25. (canceled)26. The diagnostic test device of claim 1 , wherein the test device is adapted to detect the presence of an analyte in a fluid sample applied to the test member.2728-. (canceled)29. A diagnostic test device comprising:a test member; andan electronic ...

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Номер записи: 47
25-01-2018 дата публикации

DECOMPRESSION DEVICE FOR EJACULATION PROMOTION DEVICE

Номер: US20180021212A1
Автор: MATSUURA Tsutomu
Принадлежит: TENGA Co., Ltd.

Provided is a decompression device that varies a stimulus and tightening force to a penis by adjusting pressure in a container. The decompression device is mounted to the ejaculation promotion device and includes an ejaculation promotion apparatus and a container, which is configured to decompress the container, the ejaculation promotion apparatus includes an insertion empty space and a valve section that enables communication between an inside and an outside of the insertion empty space, the container accommodating the ejaculation promotion apparatus, and the decompression device includes: a negative pressure introducing section that communicates with an air vent hole provided in the container; a negative pressure generating section that generates a negative pressure to be introduced into the container through the negative pressure introducing section and the air vent hole; and a negative pressure adjusting section that adjusts the negative pressure supplied to the container through the negative pressure introducing section. 1. A decompression device for an ejaculation promotion device , the decompression device being to be mounted to the ejaculation promotion device includingan ejaculation promotion apparatus and a container, and being configured to decompress the container, an insertion empty space extending inward from an insertion hole, and', 'a valve section that enables communication between an inside and an outside of', 'the insertion empty space; and, 'the ejaculation promotion apparatus being made of a gel-like resin and includingthe container accommodating the ejaculation promotion apparatus, a negative pressure introducing section that communicates with an air vent hole provided in the container;', 'a negative pressure generating section that generates a negative pressure to be introduced into the container through the negative pressure introducing section and the air vent hole; and', 'a negative pressure adjusting section that adjusts the negative ...

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Номер записи: 48
24-01-2019 дата публикации

CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE

Номер: US20190021704A1
Автор: Chopra Pranav, KANTAK Ameya, SAINI Sukhleen, SHASTRY Ashutosh, YABLOK Leah
Принадлежит:

A disposable cartridge can be used for biofluid sample collection, preparation, and mixing with reagents. After sample collection, the cartridge can be inserted into a reader for sample analysis. This system can be used for detecting and measuring analytes, such as drugs, in saliva for example. This is useful for point of test detection of drugs in applications such as workplace drug testing and driving under the influence of drugs testing. 1. A saliva collection system , the system comprising:a collection body;a first swab piston extending distally from the collection body, the first swab piston comprising a first internal channel configured to wick saliva from an open distal end of the first swab piston;a second swab piston extending distally from the collection body, the second swab piston comprising a second internal channel configured to wick saliva from an open distal end of the second swab piston;a diluted sample cavity in fluid connection with a proximal end of the first internal channel; anda cap having a first tube configured to receive the first swab piston and a second tube configured to receive the second channel piston;a dilution buffer within the first tube and covered by a first frangible cover that is configured to be pierced by the first swab piston when the cap is attached to the collection body;a preservation solution within the second tube and covered by a second frangible cover that is configured to be pierced by the second swab piston when the cap is attached to the collection body; anda fastener configured to secure the cap to the collection body.2. The system of claim 1 , wherein the fastener is configured to secure the cap to the collection body when a predetermined amount of force is applied claim 1 , wherein the first swab piston and first tube are configured so that securing the cap to the collection body drives the dilution buffer through the first internal channel to mix and dilute any saliva within the first internal channel and to ...

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Номер записи: 49
24-01-2019 дата публикации

SPLITTABLE FLUID SAMPLE COLLECTOR

Номер: US20190022638A1
Автор: Bodner Moishe
Принадлежит:

A splittable fluid sample collector for dividing a fluid sample into two or more portions, includes at least first and second fluid collector portions detachably connected to one another, each of the fluid collector portions including a handle and an absorbent sample pad affixed to an end of the handle. Further, a fluid sampling apparatus includes the aforementioned splittable fluid sample collector, at least one container and a closure for the container. Still further, a method for splitting a fluid sample including providing the aforementioned splittable fluid sample collector, collecting a fluid sample with the absorbent sample pads of the splittable fluid sample collector and splitting the first and second fluid collector portions of the splittable fluid sample collector from one another. 1. A splittable fluid sample collector for dividing a fluid sample into two or more portions , the splittable fluid sample collector comprising:a first fluid collector portion including a first handle and a first absorbent sample pad affixed to an end of the first handle; anda second fluid collector portion including a second handle and a second absorbent sample pad affixed to an end of the second handle;wherein the first and second fluid collector portions are disposed opposite to each other in a face-to-face manner; andwherein the first and second handles are detachably connected to each other with at least one frictionally engaging connecting element, at least one frangible weld, or a frangible adhesive.2. The splittable fluid sample collector according to claim 1 , wherein the first and second absorbent sample pads at least partially contact one another.3. The splittable fluid sample collector according to claim 1 , wherein the first and second handles are arranged opposite one another.4. The splittable fluid sample collector according to claim 1 , wherein the first and second handles each includes a finger gripping element.5. The splittable fluid sample collector according ...

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Номер записи: 50
26-01-2017 дата публикации

Saliva-Derived Measures of Telomere Abundance and Sample Collection Device

Номер: US20170023451A1
Автор: Harley Calvin
Принадлежит:

This invention provides devices and methods for sample collection. Devices can include (a) a container having an opening and adapted to receive a liquid sample through the opening; (b) a cover configured to reversibly seal the opening; and (c) a capture device configured to be introduced into the container, wherein the capture device is configured to selectively bind cells of a first type and not to substantially bind cells of a second cell type. The sample can be analyzed to make a measure of telomere abundance and the abundance can be correlated to a measure of health. 169.-. (canceled)70. A kit comprising:(a) a container having an opening adapted to receive a liquid sample through the opening;(b) a cover configured to reversibly seal the opening; and(c) a capture device configured to be introduced into the container, wherein the capture device is configured to selectively bind cells of a first type and not to substantially bind cells of a second cell type.71. The kit of claim 70 , wherein the capture device substantially binds at least one cell other than a lymphoid and/or myeloid cell.72. The kit of claim 70 , wherein the cells of a first type are targeted for removal and the cells of a second type are targeted for analysis.73. The kit of claim 70 , wherein the cells of the first type comprise epithelial cells and the cells of the second type comprise at least one of myeloid cells and lymphoid cells.74. The kit of claim 70 , wherein the capture device binds a surface molecule on epithelial cells.75. The kit of claim 74 , wherein the surface molecule is Ep-CAM.76. The kit of claim 70 , wherein the container includes a first compartment and a second compartment claim 70 , wherein:a) the first compartment and the second compartment are separated from one another by a breakable barrier;b) the first compartment is configured to receive a liquid sample from the opening in the container; 'wherein the container is configured such that breaking the breakable barrier ...

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Номер записи: 51
26-01-2017 дата публикации

Particle-based drug detection methods

Номер: US20170023453A1
Автор: Brian Clowers, Herbert H. Hill, Jr., Nicholas Lovrich
Принадлежит: Washington State University WSU

Disclosed herein are embodiments of methods for detecting the presence of and amount of drugs in a sample, particularly a particle sample obtained from a subject. In particular disclosed embodiments, the particle samples are skin particle samples, saliva particle samples, and/or mucous samples isolated from a subject and analyzed using thermal desorption methods combined with a selected detection method.

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Номер записи: 52
26-01-2017 дата публикации

Smartphone dock and diagnostic-test reader plus related methods

Номер: US20170023542A1
Автор: Jimmy Jing, Naishu Wang
Принадлежит: Individual

Disclosed is are a diagnostic test reader and related methods or systems. In one embodiment, a smartphone, including diagnostic software and a camera, may be docked onto the reader so that the camera of the phone is coupled to a diffuser for imaging test strips or other test cartridges provided to the reader. Preferably, the diagnostic software is configured to interpret an image of the strip and provide diagnostic feedback via the interface of the phone. Light for producing the image may be from the flash of the smartphone camera or a light source inside the reader. The more specific details of the disclosed reader are described in connection with the figures.

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Номер записи: 53
23-01-2020 дата публикации

Sample Collection Device and Method

Номер: US20200022684A1
Автор: "ONeill Dan H.", Devore Aaron, Sessions Travis
Принадлежит:

The present description relates to a sample collection device comprising a receptacle and a closure member configured to seal the receptacle. Within the closure member is provided a reservoir configured to contain a stabilization fluid capable of preserving and stabilizing a collected sample. The reservoir includes an outlet which is sealed by a sealing member. The sealing member may be openable to allow communication, or mixture, between the contents of the reservoir and the contents of the receptacle. The closure member may also include a peel foil on the end of the closure member having the outlet to ensure sterility of and to avoid tampering with the outlet and the reservoir. The method includes collecting a sample from the user using the sample collection device, mixing the sample with the stabilization fluid, and analyzing the sample thus collected. 1. A DNA sample collection system , the DNA sample collection system comprising:a receptacle having a closed end, an open end configured to receive a DNA sample, and a first engagement member;a cap removably engaged with the receptacle, the cap having a first cap body, a second cap body movable relative to the first cap body, and a second engagement member, the second engagement member configured to be engaged with the first engagement member to lock the first cap body in place with the receptacle at a locked configuration, the first cap body closing the open end of the receptacle at the locked configuration; anda reservoir carried by the cap, the reservoir configured to carry a stabilization fluid and be sealed by a sealing member that is secured in place by the second cap body, wherein, at the locked configuration, the second cap body is further movable relative to the first cap body that is locked in place with the receptacle, and a further movement of the second cap body displaces the sealing member relative to the first cap body to release the stabilization fluid to the receptacle.2. The DNA sample collection ...

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Номер записи: 54
10-02-2022 дата публикации

METHOD FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE

Номер: US20220042883A1
Автор: ANDREWS Stephen D., BIADILLAH Youssef
Принадлежит: DNA Genotek, Inc.

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery. 1. A method for collecting and preserving a biological sample , the method comprising:receiving a biological sample in a sample collection vessel;threading a cap onto the sample collection vessel;coupling an annular valve in the cap with the sample collection vessel, wherein coupling causes a first cylinder of the annular valve and a second cylinder of the annular valve to move relatively and thereby open a vent in the annular valve;releasing reagent from a reagent chamber in the cap, through the vent, and into a sample collection reservoir in the sample collection vessel to mix with and preserve the biological sample; andsealing an aperture of the sample collection ...

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Номер записи: 55
28-01-2021 дата публикации

SURFACE FUNCTIONALISED MATERIALS FOR SAMPLING BIOLOGICAL MOLECULES

Номер: US20210023534A1
Автор: JONES Paul Antonio
Принадлежит:

The invention relates to materials, methods and devices useful for sampling biological molecules, including biomarkers and/or metabolites. In particular, the invention relates to surface functionalised xerogels and surface functionalised poly(dimethyl) siloxane (PDMS), devices comprising those materials, and methods of using the materials and devices for sampling, analysing or detecting biological molecules. 1. A surface-functionalised xerogel comprising a functional group capable of selectively binding to a biological molecule from a subject.2. A surface-functionalised xerogel according to claim 1 , wherein the biological molecule is from a mucous membrane or biological fluid.3. A surface-functionalised xerogel according to or claim 1 , for insertion into: a body orifice claim 1 , typically a nostril claim 1 , ear canal claim 1 , mouth claim 1 , anus/rectum claim 1 , vagina claim 1 , or urethra; or a body cavity; or a bodily tube claim 1 , typically a fallopian tube.4. A surface-functionalised xerogel according to any of to claim 1 , wherein the functional group is capable of selectively binding to a cell claim 1 , protein claim 1 , lipid or nucleic acid biomarker claim 1 , or metabolite.5. A surface-functionalised xerogel according to any preceding claim claim 1 , wherein the surface-functionalised xerogel is a silica xerogel.6. A surface-functionalised xerogel according to any preceding claim claim 1 , wherein the functional group is selected from an antigen-binding protein claim 1 , a nucleic acid claim 1 , a lipid-binding moiety claim 1 , a sugar or glycoprotein; or a block group-presenting co-polymer.7. A surface-functionalised xerogel according to claim 6 , wherein:{'sub': 4', '20, 'a. the lipid-binding moiety comprises a C-Calkyl silicate functionalised silica xerogel, optionally an octadecylsilyl (ODS) group; or'}b. the sugar is mannose; orc. the antigen-binding protein is an antibody or an antigen-binding fragment thereof.8. A surface functionalised ...

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Номер записи: 56
02-02-2017 дата публикации

METHOD AND APPARATUS TO SENSE HYDRATION LEVEL OF A PERSON

Номер: US20170027506A1
Автор: Hadiwidjaja Angeline, Howell Thomas A., Schrall Corrine, Thomas C. Douglass, Tong Peter P.
Принадлежит:

A hydration sensor or sensing element is configured to measure the hydration level of a user. The sensing element can include a water-permeable material positioned in between two water-impermeable materials. The sensing element can be coupled to a bottle of fluid, or a carrier with a timer. The sensing element can be incorporated into a handheld device. The sensing element can be a disposable element, an element applicable for more than one-time use, or a re-usable element. The sensing element or sensor can be calibrated for a specific user or a group of users. One or more additional sensors that do not measure hydration level of the user can be coupled to a hydration sensing element to determine the amount of fluid consumption for the user in different conditions. 1. A disposable hydration sensing element for measuring the hydration level of a user based on the user's saliva , the sensing element comprising:a sheet of water-permeable material having a first side and a second side, with a chemical compound coupled to the water-permeable material;a first sheet of water-impermeable material coupled to the first side of the water-permeable material; anda second sheet of water-impermeable material coupled to the second side of the water-permeable material,wherein the hydration sensing element includes at least one aperture to allow saliva to reach the chemical compound from the at least one aperture,wherein the chemical compound, at least due to contact with saliva, changes at least a portion of the water-permeable material, and the change is observable from at least a portion of one of the sheets of the water-impermeable material, andwherein the disposable hydration sensing element further includes an indicator to provide an indication regarding the hydration level of the user, based on time duration regarding the observable change of the water-permeable material, if at least a portion of the at least one aperture is placed in contact with the saliva of the user.2. A ...

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Номер записи: 57
31-01-2019 дата публикации

ADVANCED ELECTROPORATION DEVICES AND METHODS FOR ANALYTE ACCESS IN BIOFLUIDS

Номер: US20190029654A1
Автор: Heikenfeld Jason C., Heller Richard
Принадлежит:

A method of collecting and sensing a biofluid with enhanced concentration of analytes due to electroporation comprises electroporating biofluid glands () that are generating a biofluid and specifically sensing at least one analyte in said biofluid, the at least one analyte having a molecular weight greater than 50 Da. A device () wearable on a user's skin () for receiving an advective flow of a biofluid comprises at least one of a biofluid stimulation component (), a biofluid sensor () specific to an analyte, or a biofluid collection element (), at least one electroporation electrode () for enhancing concentration of at least one analyte in the biofluid having a molecular weight of greater than 50 Da, a counter electrode (), and an electroporation waveform generator configured to cause the electroporation electrode () to generate and direct a plurality of electroporation pulses into the skin (). 1. A method of collecting and sensing a biofluid with enhanced concentration of analytes due to electroporation , comprising:electroporating biofluid glands that are generating a biofluid; andspecifically sensing at least one analyte in said biofluid, the at least one analyte having a molecular weight greater than 50 Da.2. The method of claim 1 , wherein the biofluid glands are sweat glands claim 1 , the method further comprising:stimulating sweat prior to electroporating the sweat glands.3. The method of claim 1 , wherein electroporating includes first applying an electroporation waveform followed by applying a chaser waveform.4. The method of claim 1 , further comprising:determining an amount of electroporation incurred by the biofluid glands.5. The method of claim 4 , wherein determining includes measuring at least one of a skin impedance claim 4 , a change in an analyte concentration claim 4 , or an advective flow of biofluid from the biofluid glands using a sensor.6. The method of claim 5 , wherein the sensor communicates with at least one electroporation element claim ...

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Номер записи: 58
01-02-2018 дата публикации

Ulcerative Colitis (UC)-Associated Colorectal Neoplasia Markers

Номер: US20180030545A1
Автор: Boland C. Richard, Goel Ajay, Okugawa Yoshinaga, Toiyama Yuji
Принадлежит:

Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients. 1103.-. (canceled)104. A method for determining increased methylation levels in genes from a sample from a patient with ulcerative colitis comprising measuring in the sample increased methylation levels for genes encoding miR-1 and miR-9 compared to a control or reference methylation level for the genes.105. The method of claim 104 , further comprising treating the patient for dysplasia or cancer.106. The method of claim 104 , wherein the sample is a tissue sample claim 104 , a whole blood sample claim 104 , a urine sample claim 104 , a saliva sample claim 104 , a serum sample or a fecal sample.107. The method of claim 104 , wherein the sample is a tissue sample.108. The method of claim 104 , wherein the sample is a rectum sample claim 104 , a colon sample or a cecum sample.109. The method of claim 104 , wherein the sample is a fresh claim 104 , frozen or preserved sample or a fine needle aspirate.110. The method of claim 104 , wherein the sample is a formalin-fixed claim 104 , paraffin-embedded (FFPE) sample.111. The method of claim 104 , wherein the method comprises evaluating a predetermined methylation profile of the gene in the sample.112. The method of claim 104 , wherein the method comprises isolating nucleic acids in the sample.113. The method of claim 104 , wherein the method comprises assaying nucleic acids in the sample.114. The method of claim 113 , wherein assaying nucleic acids comprises a methylation assay of the promoter in the gene.115. The method of claim 114 , wherein the methylation assay comprises next generation sequencing claim 114 , single-molecule real-time sequencing claim 114 , mass spectrometry claim 114 , bisulfite sequencing claim 114 , combined bisulfite restriction analysis (COBRA) claim 114 , Southern ...

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Номер записи: 59
30-01-2020 дата публикации

SAMPLE CUP

Номер: US20200030789A1
Автор: EPPERSON Jon, FREDRIKSEN Laura, Harmon Kirk, SCHAFF Ulrich
Принадлежит: Sandstone Diagnostics, Inc.

A cup used to receive, hold, measure and pour liquids, such a specimens, such as for a medical assay, is described. The cup comprises an open receiving upper chamber, two or more open sample-directing channels, and an open, calibrated and marked measuring column. When sitting on a level surface, fluid flows freely from the upper chamber through the sample-directing channels into the measuring column. A foot is under each fluid-directing channel. The base of the measuring column functions as an additional, such as a third, foot. Cups nest, with the two feet of the upper cup sitting into two sample-directing columns of lower cup. The measuring column and upper chamber taper to permit nesting. If the cup is tipped, it rests on two of three of: the two feet and the base of the measuring column, and a point on a lower perimeter of the upper chamber, such that fluid will not spill. 1. A cup comprising:an upper chamber open at the top of the cup;two sample-directing chambers fluidly connected to the upper chamber;a measuring chamber fluidly connected to the sample-directing chambers;wherein the sample-directing chambers and the measuring chamber each comprise a base and wherein the cup rests level supported by the bases, when on a horizontal surface;wherein, when the cup is on a horizontal surface, a fluid placed in the upper chamber flows under gravity into at least one of the sample-directing chambers and thence to the measuring chamber.2. The cup of claim 1 , wherein:the cup comprises exactly two sample-directing chambers.3. The cup of claim 1 , wherein:each sample-directing chamber is substantially in the form of a channel, open on the top to the upper chamber and comprising a sloped bottom leading into the measuring chamber; andwherein a base of the upper chamber is sloped towards any combination of sample-directing chambers and the measuring chamber.4. The cup of claim 1 , wherein:when the cup is on a horizontal surface, gravity causes fluid to flow freely from the ...

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Номер записи: 60
09-02-2017 дата публикации

FLUID COLLECTION DEVICE

Номер: US20170036205A1
Автор: Bishop Oliver, Childs Ben
Принадлежит: THE SECRETARY OF STATE FOR HEALTH

A fluid collection device comprising an elongate container having an opening at one end, and a swab that is insertable into the container through said opening, wherein: the swab comprises an absorbent collector, for acquiring a fluid sample in use; and the internal cross-sectional area of the container becomes smaller in a direction away from the opening, the internal cross-sectional area becoming sufficiently small so as to cause the absorbent collector to be radially compressed as the swab is inserted into the container in use, thereby causing the absorbent collector to release at least some of the fluid sample held therein. The swab may further comprise a shaft, the absorbent collector being at or near a distal end of the shaft, and a closure being at or near a proximal end of the shaft, the closure being adapted to engage with the container and to close the opening of the container with the absorbent collector inside the container. The closure may further comprise an outlet through which fluid within the container can be dispensed in use, subsequent to the closure having been engaged with the container. 1. A fluid collection device comprising an elongate container having an opening at one end , and a swab that is insertable into the container through said opening , wherein:the swab comprises an absorbent collector, for acquiring a fluid sample in use; andthe internal cross-sectional area of the container becomes smaller in a direction away from the opening, the internal cross-sectional area becoming sufficiently small so as to cause the absorbent collector to be radially compressed as the swab is inserted into the container in use, thereby causing the absorbent collector to release at least some of the fluid sample held therein.2. A fluid collection device as claimed in claim 1 , wherein the length of the swab and the length of the container are such that the absorbent collector reaches a maximum degree of radial compression at or near the far end of the ...

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Номер записи: 61
07-02-2019 дата публикации

Straw for the preservation of a predetermined dose of liquid-based substance

Номер: US20190038388A1
Автор: GORGES Jean-Charles, SCHMITT Eric
Принадлежит:

The straw comprises a tube () and a gas-permeable liquid-tight stopper (), which stopper is disposed in the tube in the neighborhood of one end (), which tube and which stopper are configured for the stopper to be able to slide in the tube towards the other end (), said tube being transparent or translucent, said stopper comprising an identifier component () configured to emit, when it is illuminated with ultraviolet light, light of which the spectrum comprises at least one peak having a crest of predetermined wavelength in visible light, whereas when it is illuminated by visible light said identifier component does not emit said light of which the spectrum comprises said peak. 1. A straw for the preservation of a predetermined dose of liquid-based substance , comprising a tube and a gas-permeable liquid-tight stopper , which stopper is disposed in the tube in the neighborhood of one end , which tube and which stopper are configured for the stopper to be able to slide in the tube towards the other end , said tube being transparent or translucent , wherein said stopper comprises an identifier component configured to emit , when it is illuminated with ultraviolet light , light of which the spectrum comprises at least one peak having a crest of predetermined wavelength in visible light , whereas when it is illuminated by visible light said identifier component does not emit said light of which the spectrum comprises said peak.2. A straw according to claim 1 , wherein said stopper is formed by two plugs made from a braided fibrous substance enclosing a sealing agent formed by a powder claim 1 , with at least one of the two plugs forming said indicator component.3. A straw according to claim 2 , wherein said at least one plug forming said indicator component is a braid of which the threads are coated with an optical agent emitting claim 2 , when it is illuminated with ultraviolet light claim 2 , said light of which the spectrum comprises said peak claim 2 , whereas when ...

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Номер записи: 62
03-03-2022 дата публикации

Liquid Collection Device

Номер: US20220061822A1
Автор: Carpio, Chang Yuan, Fitzpatrick Kathleen, III Robert, Maharsia Rahul, Robbins Avi, Shahidani Saman Mahdavi, Shelly Hayden, Streiff Micah
Принадлежит:

A liquid specimen collection device. Various embodiments implement oral fluid collection, extraction, storage, and/or testing. The device can be used to collect fluid, and to then extract and prepare the fluid for analysis, which can eliminate human error in collection and reduce complexity in diagnostic analysis. The disclosed device may be used to collect any liquid specimen. Any instance when liquid should be collected, stored, and tested may benefit from use of this disclosure. 1. A fluid collection device , comprising:a collection pad;a device body; anda collection container,wherein the collection pad is secured to a first end of the device body and wherein the collection container is positioned at a second end of the device body.2. The device of claim 1 , wherein the collection container is integrally formed with the device body to provide a one-piece device.3. The device of claim 1 , wherein the collection container is removeably secured to the device body.4. The device of claim 3 , wherein the collection container is threadingly secured to the device body.5. The device of claim 1 , further comprising a nozzle positioned within the device body for directing collected fluid.6. The device of claim 1 , wherein fluid collected via the collection pad is collected at a first end of the collection pad claim 1 , travels through the collection pad claim 1 , and exits at a second end of the collection pad claim 1 , into the collection container.7. The device of claim 1 , further comprising a filter positioned to filter collected fluid.8. The device of claim 7 , wherein the filter comprises fiber components claim 7 , track-etched-membranes claim 7 , sintered particles claim 7 , or any combination thereof.9. The device of claim 1 , further comprising a cap with a length configured to be positioned over and cover the collection pad.10. The device of claim 1 , further comprising a buffer claim 1 , additive claim 1 , or reagent incorporated into the fluid collection device. ...

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Номер записи: 63
03-03-2022 дата публикации

METHOD FOR OBTAINING EXHALED RESPIRATORY SPECIMENS

Номер: US20220061823A1
Автор: Berger Barry M., Kuperwasser Charlotte
Принадлежит:

The invention provides articles, devices, and methods for sampling respiratory droplets, the article comprising a material capable of adsorbing or absorbing respiratory droplets such that the contents of said respiratory droplets can be recovered for analysis. The invention allows respiratory droplets to be collected directly from any source of moisture and commonly-used devices, for example face masks and air handling systems.

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Номер записи: 64
03-03-2022 дата публикации

Container for Sample Collection

Номер: US20220061824A1
Автор: Emil Andersen, Morten Gorm ULSTED
Принадлежит: EXSEED HEALTH APS

Disclosed is a container for collection of a biological sample, specifically semen, comprising a cup having an open top and an opposite, closed bottom, an accommodating space for receiving said sample and a depression defined by a side wall and a raised part of said bottom, a lid attachable to said top of said cup for closing in an assembled position of the container, wherein the lid comprises a pipetting element with a channel, so that when the lid and cup are attached in the assembled position of the container, the pipetting element extends into the depression of said cup, whereby said channel enables fluid communication between an outside environment of the container and said depression.

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Номер записи: 65
03-03-2022 дата публикации

Swab device with embedded test element

Номер: US20220062890A1
Автор: Daniel Larkin
Принадлежит: Individual

A swab device, according to an example, includes a handle shaft, and a collection element positioned at a distal end of the handle shaft to collect a biological sample. The swab device includes an embedded test element to perform a test on the collected sample and provide an indication of a result of the test.

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Номер записи: 66
25-02-2021 дата публикации

Device for Collecting, Transferring, and Storing Samples of a Biological and/or Chemical Material

Номер: US20210053049A1
Автор: Giorgio Martello
Принадлежит: Copan Italia SpA

A device for collecting, transferring, and storing samples of a biological and/or chemical material, wherein the device comprises: a support body, developing along a main longitudinal direction between a first end and a second end opposite to each other and connected by an intermediate portion elongate in the main longitudinal direction, a collection portion engaging the first end and configured to collect a quantity of a sample of a biological and/or chemical material, the collection portion being defined at least by a first coating layer realized on the first end and made from an elastically deformable material and by a second coating layer consisting of a layer of flocked fibers, the second coating layer being realized through a fiber flocking process on the first coating layer and being configured to absorb a quantity of liquid including at least one sample of a biological and/or chemical material.

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Номер записи: 67
14-02-2019 дата публикации

Integrated device for analyte testing, confirmation, and donor identity verification

Номер: US20190049442A1
Автор: Raouf A. Guirguis
Принадлежит: Zeus Diagnostics LLC

An apparatus for testing a fluid sample including a sample receiving member having an opening for receiving a fluid sample, wherein the sample receiving member comprises a sample collection chamber; a fluid collector to collect the fluid sample and transfer the fluid sample into the sample receiving member, the fluid collector comprising a lancet and an absorbent material to absorb the fluid sample; and a test cartridge member in fluid communication with the sample collection chamber.

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Номер записи: 68
10-03-2022 дата публикации

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

Номер: US20220071533A1
Автор: Bullington Gregory J., GAW Shan E., MIAZGA Jay M., Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139.-. (canceled)40. A blood transfer system , comprising:a first lumen-containing device fluidically coupleable to a patient;a transfer device having an inlet port in fluid communication with the first lumen-containing device, the transfer device defining a first fluid flow path and a second fluid flow path, the transfer device having a seal member disposed at an end portion of the first fluid flow path, a first volume of blood allowed to flow through the first fluid flow path toward the seal member when the transfer device is in a first state, the transfer device retaining the first volume of blood and allowing a second volume of blood to flow through the second fluid flow path while bypassing at least a portion of the first fluid flow path when the transfer device is in a second state; anda second lumen-containing device fluidically coupleable to a sample reservoir external to the transfer device, the second lumen-containing device configured to receive the second volume of blood from the second fluid flow path when the transfer device is in the second state.41. The blood transfer system ...

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Номер записи: 69
10-03-2022 дата публикации

DELIVERING AND/OR RECEIVING FLUIDS

Номер: US20220071534A9
Автор: Bernstein Howard, Boccuti A. David, Chickering, Dadgar Maisam, Davis Shawn, Fisher Greg, Gonzalez-Zugasti Javier, Haghgooie Ramin, III Donald E., James Scott, Levinson Douglas A., Michelman Mark, Miller Richard L., Morse Christopher J.
Принадлежит: YourBio Health, Inc.

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. 130-. (canceled)31. A device for receiving fluid from a subject , comprising:a device actuator;a housing including an opening to receive fluid into the housing;a flow activator comprising at least one needle;a vacuum source;a deployment actuator configured to move the flow activator in a deployment direction;an effector and an effector guide, wherein the effector is guided in motion via the effector guide in the deployment direction and a retraction direction, wherein the deployment actuator is held by the effector; anda retraction actuator configured to move the effector in the retraction direction.32. The device of claim 31 , wherein a portion of the deployment actuator is displaceable relative to the effector.33. The device of claim 31 , wherein the effector guide includes a slot that receives the effector claim 31 , wherein the effector moves along the slot in the deployment direction and in the retraction direction.34. The device of claim 31 , wherein the effector guide includes a first slot and a second slot claim 31 , wherein the effector moves along the first slot and the second slot in the deployment direction and the retraction direction.35. The device of claim ...

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Номер записи: 70
10-03-2022 дата публикации

SAMPLE COLLECTION DEVICES

Номер: US20220071604A1
Автор: Mide Christian, Schön Jimmy Gidö
Принадлежит:

A sample collection device for collecting a fluid sample is provided. The device includes a sample collection chamber, for collecting a sample therein, having a first end and a second end and a sample collection conduit, for conveying a sample from a user into the sample collection chamber. The sample collection conduit includes an inlet for receiving a sample and wherein in at least a first position the sample collection conduit extends from within the sample collection chamber out through the first end such that at least the inlet is outside of the sample collection chamber. The device further includes a plunger configured to expel the sample out of the sample collection chamber through the second end of the sample collection chamber. 1. A sample collection device , for collecting a fluid sample , comprising:a sample collection chamber, for collecting a sample therein, having a first end and a second end;a sample collection conduit, for conveying a sample from a user into the sample collection chamber, wherein the sample collection conduit comprises an inlet for receiving a sample and wherein in at least a first position the sample collection conduit extends from within the sample collection chamber out through the first end such that at least the inlet is outside of the sample collection chamber; anda plunger configured to expel the sample out of the sample collection chamber through the second end of the sample collection chamber.2. The sample collection device as claimed in claim 1 , wherein the sample collection conduit and plunger are operatively linked such that movement of the sample collection conduit causes movement of the plunger.3. The sample collection device as claimed in claim 1 , further comprising a seal arranged to close second end of the sample collection chamber claim 1 , and wherein the sample collection conduit and/or the plunger is configured to break the seal when moved towards a second position in which the sample collection conduit is ...

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Номер записи: 71
15-05-2014 дата публикации

Sperm Collecting Device

Номер: US20140135650A1
Автор: Wu Wei
Принадлежит: LOVER HEALTH SCIENCE AND TECHNOLOGY CO., LTD.

A sperm collecting device is provided. The sperm collecting device includes a main body, a cap that is separately connected to a first end of the main body, a hanger that is rotatably connected to a second end of the main body and a soft body that is disposed in the main body and having a penis passage. The sperm collecting device further includes a pressing unit. The pressing unit includes a pressing element and a pressing plate, wherein the pressing element is disposed at the main body, and the main body has a pressing opening disposed corresponding to a pressing portion of the pressing element. The pressing plate is disposed between the main body and the soft body corresponding to the pressing opening. 1. A sperm collecting device , comprising:a main body;a cap, separately connected to a first end of the main body;a hanger, rotatably connected to a second end of the main body;a soft body, disposed in the main body and having a penis passage; anda pressing unit, including a pressing element and a pressing plate, wherein the pressing element is disposed at the main body, the main body has a pressing opening disposed corresponding to a pressing portion of the pressing element, and corresponding to the pressing opening, the pressing plate is disposed between the main body and the soft body.2. The sperm collecting device according to claim 1 , wherein the main body comprises a large cylindrical body and a small cylindrical body claim 1 , a first end of the large cylindrical body is separately connected to the cap claim 1 , and a second end of the large cylindrical body is connected to the small cylindrical body.3. The sperm collecting device according to claim 1 , wherein the pressing element is substantially cylindrical in shape claim 1 , and the pressing element is sleeved on the outside of the main body or sleeved between the pressing plate and the main body.4. The sperm collecting device according to claim 1 , wherein the pressing element is inlaid in the pressing ...

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Номер записи: 72
05-03-2015 дата публикации

SALIVA CONTAINER WITH OPTICAL VOLUME INDICATOR

Номер: US20150064080A1
Автор: Skakoon James G.
Принадлежит:

A device with a vessel for saliva that has one or more optical indicators to show the volume of saliva in the container. The optical indicators use the principle of total internal reflection together with the difference in refractive index between saliva and air. In embodiments, suitable visual indicators are either visible or invisible, when reflecting surfaces are either not immersed or immersed in saliva or vice versa. The device may comprise a vessel with a saliva pathway, a saliva containment region defining a saliva reservoir, the reservoir having a desired fill level, and an optical viewing window adjacent an angled reflective surface for level indication and/or validating a fill level. The device may include patient interface components and chemical test strips. 1. A container for collecting saliva comprising:a collection vessel with a saliva reservoir;a cap;the collection vessel including a reflecting surface in or at the saliva reservoir providing a changeable reflecting characteristic dependent of the presence of saliva at the reflecting surface;a visual marker that is one of viewable or not viewable by an observer when looking at the reflecting surface dependent upon the changeable reflecting characteristic.2. The container of wherein claim 1 , due to total internal reflection claim 1 , the visual marker is one of visible and invisible when said collection vessel is empty claim 1 , and the other of invisible and visible when said collection vessel is filled with a predetermined volume of saliva.3. The device of further having gradations indicating collected volume.4. The device of wherein the visual marker comprises one of a figure claim 1 , a color swatch claim 1 , and text.5. The device of comprising a plurality of reflecting surfaces.6. The device of wherein the visual marker comprises a light source.7. The device of wherein visible and invisible is determined by electronic sensors.8. A device for collecting saliva comprising:a mouthpiece coupled to ...

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Номер записи: 73
28-02-2019 дата публикации

SMARTGRIP BIOMETRIC ELECTRONIC TABLET STAND

Номер: US20190059749A1
Автор: Gough Joseph W
Принадлежит: CareVoice Inc

A biometric electronic tablet device for a user includes a base platform adapted to enclose an electronic tablet for the user and a plurality of legs extending from the base platform and downwardly and adapted to contact a support surface to elevate the base platform and the electronic tablet over the user. The biometric electronic tablet stand includes biometric sensors for acquiring a grip strength and biometric data of a user. 1. An adjustable biometric measuring device for a user , comprising: a base platform adapted to enclose and interact with an electronic tablet; and a plurality of legs extending from said base platform and downwardly , adapted to contact a support surface to elevate said base platform and the electronic tablet over the user.2. The biometric measuring device as set forth in including a tablet enclosure adapted for enclosing the electronic tablet.3. The biometric measuring device as set forth in wherein said tablet enclosure expands and retracts to allow for multiple size electronic tablets.4. The biometric measuring device as set forth in including a locking mechanism to keep said tablet enclosure from being opened by public users.5. The biometric measuring device as set forth in wherein said tablet enclosure includes a screen shield for biohazard protection of the electronic tablet.6. The biometric measuring device as set forth in including one or more biometric sensor(s) that are adapted to be gripped by the user to sense the grip strength of the user.7. The biometric measuring device as set forth in including one or more biometric sensor(s) adapted for sensing vital signs including diastolic and systolic blood pressure claim 1 , blood oxygen levels claim 1 , respiration rate claim 1 , pulse rate claim 1 , blood chemistry claim 1 , blood glucose claim 1 , temperature claim 1 , and/or frailty of the user.8. The biometric measuring device as set forth in wherein said one or more biometric sensor(s) comprise a glucometer for blood glucose ...

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Номер записи: 74
17-03-2022 дата публикации

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

Номер: US20220079482A1
Автор: Bullington Gregory J., GAW Shan E., MIAZGA Jay M., Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139.-. (canceled)40. A blood transfer system , comprising:an access device at least partially insertable into a patient;a first tubing fluidically coupleable to the access device;a transfer device having an inlet port fluidically coupled to the first tubing, the transfer device having a seal member disposed at an end portion of a first fluid flow path and at least partially defining an inner volume, the inner volume receiving a first volume of blood flowing through the first fluid flow path toward the seal member when the transfer device is in a first state, the transfer device allowing a second volume of blood to flow from the inlet port via a second fluid flow path toward an outlet port while bypassing the inner volume when the transfer device is in a second state; anda second tubing fluidically coupleable to a sample reservoir external to the transfer device, the second volume of blood flowing from the second fluid flow path into the second tubing when the transfer device is in the second state.41. The blood transfer system of claim 40 , wherein the inlet port defines a lumen claim 40 , ...

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Номер записи: 75
27-02-2020 дата публикации

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

Номер: US20200060595A1
Автор: Bullington Gregory J., GAW Shan E., MIAZGA Jay M., Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 1. A device for procuring bodily-fluid samples from a patient , the device comprising:a housing including a proximal end portion and a distal end portion and defining an inner volume therebetween, the housing having an inlet port configured to be fluidically coupled to the patient, and an outlet port configured to be fluidically coupled to a sample reservoir;a fluid reservoir disposed in the inner volume and configured to receive and isolate a first volume of bodily-fluid withdrawn from the patient;a flow control mechanism disposed in the housing and defining a first lumen and a second lumen, the flow control mechanism configured for rotational movement from a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that bodily-fluid can flow from the inlet port, through the first lumen and to the fluid reservoir, to a second configuration, in which the inlet port is placed in fluid communication with the outlet port such that the bodily-fluid can flow from the inlet, through the second lumen and to the outlet port; andan actuator operably ...

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Номер записи: 76
27-02-2020 дата публикации

SYSTEMS AND METHODS FOR PARENTERALLY PROCURING BODILY-FLUID SAMPLES WITH REDUCED CONTAMINATION

Номер: US20200060596A1
Автор: Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media. 1. A system for parenterally procuring bodily-fluid samples from a patient with minimal contamination , the system comprising: a first sterile needle configured and arranged for insertion into a patient, the first sterile needle comprising a first lumen configured and arranged for withdrawing patient bodily fluids and passing the withdrawn bodily fluids through the first lumen,', 'a second sterile needle in fluid communication with the first sterile needle, the second sterile needle comprising a second lumen configured and arranged for passing withdrawn bodily fluids through the second lumen, and, 'a bodily-fluid withdrawing device, the bodily-fluid withdrawing device comprising'}at least one vacuum-sealed pre-sample reservoir, each of the at least one vacuum-sealed pre-sample reservoirs configured and arranged for collecting and storing patient bodily fluid withdrawn from the bodily-fluid withdrawing device; andat least one vacuum-sealed sample vessel, each of the at least one vacuum-sealed sample vessels configured and arranged for collecting and storing patient bodily fluid withdrawn from the bodily-fluid withdrawing device, each of the at least one sample vessels containing a culture medium.2. The system of claim 1 , wherein each of the at least one vacuum-scaled pre-sample reservoirs defines a first mouth with a first ...

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Номер записи: 77
17-03-2022 дата публикации

METHOD, SYSTEM AND APPARATUS FOR RESPIRATORY TESTING

Номер: US20220081730A1
Автор: Davidson John F., Joaquim Tony, Xue Zheng
Принадлежит: Tangen Biosciences, Inc.

The disclosure relates to method, system and apparatus for respiratory testing. In one implementation, a method for detecting one or more pathogens causing a respiratory infection includes the steps of: (1) combining a quantity of mucous sample from a patient with a fluidic reagent to form a test reagent, the mucous sample further comprising at least one pathogen; (2) filtering the test reagent through a large volume concentrator to obtain a filtered solution; and (3) introducing the filtered solution onto a disc having a plurality of test site, wherein each of the plurality of test sites further comprises at least one agent to bind with the at least one pathogen to detect presence or absence of an infection caused by the at least one pathogen. The mucus sample may be obtained from nasal, nasopharyngeal or throat regions of the patient. 1. A method for detecting one or more pathogens causing one or more respiratory infections , the method comprising:combining a quantity of mucous sample from a patient with a fluidic reagent to form a test reagent, the mucous sample further comprising at least one pathogen;filtering the test reagent through a large volume concentrator to obtain a filtered solution; andintroducing the filtered solution onto a disc having a plurality of test site, wherein each of the plurality of test sites further comprises at least one agent to bind with the at least one pathogen to detect presence or absence of an infection caused by the at least one pathogen;wherein the mucus sample is obtained from nasal, nasopharyngeal or throat regions of the patient.2. The method of claim 1 , wherein the fluidic reagent comprises one or more of assay buffers claim 1 , water claim 1 , lysis reagents.3. The method of claim 1 , wherein the fluidic reagent excludes RNA extraction.4. The method of claim 2 , wherein the reagent comprises lyophilized reagents including nucleotides claim 2 , DNA polymerase enzyme claim 2 , Rnase inhibitor.5. The method of claim 1 , ...

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Номер записи: 78
27-02-2020 дата публикации

DRUG DETECTION VIA SURFACE ENHANCED RAMAN SPECTROSCOPY

Номер: US20200061604A1
Автор: FREMMER Markus, Stadthagen Torsten
Принадлежит:

The present invention relates to a method for determining an analyte using surface enhanced RAMAN spectroscopy and to a device which is suitable for this purpose. 1. A kit for determining an analyte in a sample comprising:(a) a sampling device configured for taking up a sample containing an analyte, wherein the sampling device comprises a sample matrix; and a first region which is configured for introducing the sampling device; and', 'a second region which is configured for detecting the presence and/or amount of the analyte in said sample via surface enhanced Raman spectroscopy., '(b) an analysis device, comprising2. The kit of claim 1 , wherein the sampling device comprises a volume indicator.3. The kit of claim 2 , wherein the sample matrix of the sampling device comprises an absorptive material configured to absorb the analyte-containing sample and to release it upon contact with an eluent and/or mechanical compression.4. The kit of claim 1 , wherein the sampling device comprises at least two separate parts claim 1 , wherein the first part comprises the sample matrix and the second part comprises an eluent for eluting the analyte from the sample matrix.5. The kit of claim 1 , wherein the analysis device comprises a microfluidic structure.6. The kit of claim 16 , wherein the eluent present in the sampling device and/or in the analysis device comprises SERS-active nanoparticles dispersed therein.7. The kit of claim 16 , wherein the second region comprises SERS-active nanoparticles claim 16 , in particular including dry SERS-active nanoparticles or a dispersion of SERS-active nanoparticles.8. The kit of claim 1 , wherein the second region comprises a hollow-core optical fiber.9. The kit of claim 8 , wherein the hollow-core optical fiber is coated on its inside surface with a SERS-active coating claim 8 , the coating comprising SERS-active nanoparticles.10. The kit of further comprising:a radiation source for generating monochromatic light;a detector for detecting ...

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Номер записи: 79
10-03-2016 дата публикации

Systems And Methods To Determine Body Drug Concentration From An Oral Fluid

Номер: US20160069847A1
Автор: Stripp Richard
Принадлежит:

Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration. 1. A method for calculating a plasma drug concentration from a measured oral fluid drug level , the method comprising the steps:collecting a sample of oral fluid from a donor;determining the pH of the sample;identifying at least one drug in the sample wherein the identification of the at least one drug comprises determining a concentration of the drug in the sample;calculating a blood plasma drug concentration of the at least one drug from the determined concentration of the drug in the sample.2. The method of further comprising determining a total body drug concentration from the calculated blood plasma drug concentration.3. The method of wherein the at least one drug comprises a plurality of drugs.4. The method of further comprising the step of collecting a predefined volume of oral fluid from the donor.5. The method of wherein the pH is determined by providing visual indicia of the pH.6. The method of wherein the predefined volume of the sample is collected with a simultaneous measurement of the sample pH.7. The method of further comprising the step of readying the sample for transfer to a laboratory by placing the sample in an appropriate buffer claim 1 , and sealing and packing the sample.8. ...

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Номер записи: 80
17-03-2022 дата публикации

Method for analyzing biomaterials based on image analysis and personalization data

Номер: US20220084199A1
Автор: Hangchan KIM, Sanghyun Lee, Seokho KIM, Seunghyun Kim, Sukyong LEE
Принадлежит: SAMSUNG ELECTRONICS CO LTD

An electronic device and a control method of an electronic device are provided. The control method includes obtaining an image on the diagnostic kit through a camera included in the electronic device, the obtaining of the image based on receiving a user command for photographing a diagnostic kit including at least one test line discolored according to a reaction between a sample collected from a body of a user and a reagent, and a plurality of tone distinction markers with tones different from one another, obtaining a first color value on the at least one test line included in the obtained image and a second color value on each of the plurality of tone distinction markers, obtaining a first deviation information on a photographing environment of the obtained image, correcting a first data to obtain a biometric information measurement value, and obtaining a diagnostic result corresponding to the measurement value.

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Номер записи: 81
11-03-2021 дата публикации

Liquid collecting device

Номер: US20210070598A1
Автор: JIN Pan, Liqing Xu, Weiwei Li, Zhongqi YIN
Принадлежит: Linkgen Biotech Shanghai Co Ltd

Provided is a liquid collecting device, which comprises a collecting container, wherein the collecting container is provided with a diversion cavity for diverting a body fluid collected; on a wall of the collecting container, at least one jacket cavity configured to store a storage liquid is provided, the jacket cavity is provided around the diversion cavity, and the jacket cavity extends along an axial direction of the diversion cavity, and a cross section of the jacket cavity is annular; and the diversion cavity has an inflow port and an outflow port, and an aperture of the inflow port is larger than that of the outflow port.

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Номер записи: 82
12-03-2015 дата публикации

DEVICE AND METHOD FOR USE IN THE COLLECTION OF WHOLE SALIVA IN RESEARCH AND DIAGNOSTICS

Номер: US20150073305A1
Автор: Granger Douglas A., Schroeder Hans W.
Принадлежит: Salivabio, LLC

An embodiment in accordance with the present invention provides a device for collecting a specimen of oral fluids. The device includes an elongate tubular member with a first end being configured to come into contact with a mouth of a subject. The device also includes a coupler, wherein the first end of the coupler is configured to couple to a second end of the elongate tubular member and wherein the second end of the coupler is configured to couple the device to a collection vial. A chamber is defined by the outer wall of the elongate tubular member and positioned proximate to the second end of the elongate tubular member, and a filter is disposed within the chamber. An exhaust port is defined by the coupler to allow pressure to escape from the device to ease the collection of the specimen. 1. A device for collecting a specimen of oral fluids comprising:an elongate tubular member, having a first end and a second end and an outer wall defining a lumen extending therethrough wherein the first end of the elongate tubular member is configured to come into contact with a mouth of a subject;a coupler having a first end and a second end and an outer wall defining a lumen extending therethrough, wherein a first end of the coupler is configured to couple to a second end of the elongate tubular member and wherein the second end of the coupler is configured to couple the device to a collection vial;a chamber defined by the outer wall of the elongate tubular member and positioned proximate to the second end of the elongate tubular member;a filter disposed within the chamber; andan exhaust port defined by the coupler to allow pressure to escape from the device.2. The device of wherein the filter further comprises a polymer blended foam or other material.3. The device of further comprising a treated coupler.4. The device of wherein the treated coupler further comprises a coupler treated with at least one selected from the group of a bacteria static agent to enable the specimen ...

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Номер записи: 83
15-03-2018 дата публикации

FLEXIBLE TUBE ASSEMBLY

Номер: US20180070927A9
Автор: AKUTAGAWA AYAKA, Hatta Tomonori, MIYAZAKI Kaoru, Tada Yuichi
Принадлежит:

A flexible tube assembly according to the present disclosure includes a multiple tube having at least a first tubular member that has an elongated shape and is hollow and a second tubular member that has an elongated shape and is disposed inside the first tubular member in such a manner as to be capable of advancing and retreating relative to the first tubular member; and a hand operation unit that is provided on a proximal side of the multiple tube and operates at least the first tubular member and the second tubular member. The hand operation unit includes a curving operation unit that is connected to the first tubular member or the second tubular member and curves the first tubular member or the second tubular member that is connected, a slide unit that causes the second tubular member to make slide movement relative to the first tubular member, and a switching operation unit that makes switching between a state in which the first tubular member and the second tubular member are fixed to each other and a state in which fixing between the first tubular member and the second tubular member is released. 1. A flexible tube assembly comprising:a multiple tube having at least a first tubular member that has an elongated shape and is hollow and a second tubular member that has an elongated shape and is disposed inside the first tubular member in such a manner as to be capable of advancing and retreating relative to the first tubular member; anda hand operation unit that is provided on a proximal side of the multiple tube and operates at least the first tubular member and the second tubular member, a curving operation unit that is connected to the first tubular member or the second tubular member and curves the first tubular member or the second tubular member that is connected,', 'a slide unit that causes the second tubular member to make slide movement relative to the first tubular member, and', 'a switching operation unit that makes switching between a state in which ...

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Номер записи: 84
16-03-2017 дата публикации

System and method for non-invasive monitoring

Номер: US20170071580A1
Автор: ARTSYUKHOVICH Alex, YU Lingfeng
Принадлежит:

This invention describes a method and device for big data approach in integrated patient care. It combines breath and saliva chemical analysis with physical signs analysis to use big data analysis for diagnosing a disease state based on the determined concentration of the group of gas compounds and physical parameters. 1. A method comprising:collecting a sample of exhaled breath from a subject;collecting a sample of saliva for chemical analysis;collecting physical parameters from a subject;determining concentrations of a group of chemical compounds in the collected sample; anddiagnosing a disease state based on the determined concentration of the group of chemical compounds and physical parameters.2. A method comprising:collecting a set of samples of exhaled breath and physical parameters from a subject over aperiod of time; determining normalized concentrations of a group of chemical compounds ineach collected sample of exhaled breath and saliva;determining a change in the normalized concentrations of the group of chemical compounds over the period of time; determining a change of physical parameters over the period of time; andevaluating an disease state of the subject based on the determined change in the normalized concentration of the group of chemical compounds and physical parameters.3. A device , comprising:a breath collector configured to receive exhaled breath from a subject;one or more sensors configured to output a concentration of a group of gas compounds in the inhaled breath and output a concentration of said group of compounds in the received exhaled breath; andone or more sensors configures to detect physical parameters (including at least one of the Pulse Rate, Breathing rate, Thermometer, Blood pressure, tremor and humidity parameters) from the subject; andone or more sensors configures to detect chemicals in collected samples of saliva, anda processor operably coupled to the one or more sensors and further configured to take parameters of said ...

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Номер записи: 85
16-03-2017 дата публикации

FLUID SAMPLE COLLECTION AND PRESERVATION SYSTEM

Номер: US20170071582A1
Автор: Buck Robert L., Giddings Jason, SLOWEY PAUL D.
Принадлежит: Oasis Diagnostics Corporation

A sample collection system includes a sample collector having a handle with a collection strip retainer and male threaded portion disposed around the retainer, a collection strip extending from the retainer, wherein the collection strip has a pre-determined maximum load for the sample fluid and a sample volume adequacy indicator; a transport tube including a coupling to removably receive a transport tube cap and a female threaded portion to removably receive the sample collector male threaded portion, the transport tube including visually discernable graduated scale and being a translucent or transparent; and, a predetermined volume of buffer solution disposed within the transport tube cylinder. A method for collecting a fluid sample of adequate volume and known dilution factor is provided utilizing the sample collection system. 1. A body fluid sample collection system , comprising:a sample collector a handle the handle extending from a first gripping portion to a second portion, the second portion including a collection strip retainer and male threaded portion disposed around the collection strip retainer,', 'a collection strip extending out from the collection strip retainer, wherein the collection strip has a pre-determined maximum load for the selected sample fluid; and,', 'a sample volume adequacy indicator;, 'the sample collector comprisinga transport tube comprising a cylindrical body extending from a first closed end to a second open end, the first end further including a coupling to removably receive a transport tube cap, the second end further including a male threaded portion to removably engage a transport tube cap and a female threaded portion to removably receive the sample collector male threaded portion, the transport tube cylindrical body further including visually discernable graduated scale and wherein the transport tube cylindrical body is either translucent or transparent;a transport tube cap having a threaded portion to removably gage the ...

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Номер записи: 86
05-03-2020 дата публикации

APPARATUS AND METHOD TO ISOLATE SPERM BASED ON PLANAR-CONFINED SWIMMING

Номер: US20200069296A1
Автор: RIORDON JASON, Sinton David, TARLAN FARHANG
Принадлежит:

The present invention provides a microfluidic device with a confined geometry for isolating a slither-capable subpopulation of sperm which is of higher quality than the raw sperm population. The proposed device isolates slither-capable sperm based on their ability to enter and traverse a confined region where 3D locomotion is restricted. The DNA integrity of the selected sperm was higher than that of the corresponding raw samples by 55% and 122% for donors and patients, respectively. In side-by-side testing this method outperforms current clinical selection methods, density gradient centrifugation and swim-up, as well as sperm selected via general motility. Slithering represents a viable selection mechanism, readily applicable to clinical workflows with the potential to improve outcomes for couples and offspring. 1. A microfluidic device for isolating sperm of a desired quality , the device comprising:a) an inlet reservoir which for holding a raw sperm sample;b) an outlet reservoir for collecting sperm separated from the sample; andc) one or more selection channels disposed between said inlet reservoir and said selection channels to provide fluid communication between the inlet reservoir and outlet reservoir, the one or more selection channels being geometrically configured to impede helical locomotion of a subpopulation of sperm and allow 2D slither swimming of a slither capable subset of sperm within the said one or more selection channels.2. The microfluidic device of wherein the one or more selection channels have a dimension that is sufficiently low so as to restrict the helical locomotion of sperm within said one or more selection channels.3. The microfluidic device of wherein the one or more selection channels have a channel dimension in a range from 1.0 μm to 10.0 μm.4. The microfluidic device of wherein a length of each of said one or more selection channels is in a range from 1 μm to 10 cm and encourages a slither swimming subset of sperm to traverse said ...

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Номер записи: 87
14-03-2019 дата публикации

Method and Device For The Collection Of Oral Fluids

Номер: US20190076131A1
Автор: Karlsson Roger
Принадлежит:

The present invention relates to a method and device for collection of oral fluids comprising the use of a sealed evacuated sample container. 1. A method for collecting oral fluids , the method comprising the provision of:at least a collecting member configured for the collection of oral fluids when present in an oral cavity, comprising a flexible intra oral member and a rigid member, the flexible intra oral member, comprising at least one opening;and a sealed evacuated sample container,the method comprising:placement of the flexible intra oral member in the oral cavity,collection of the oral fluids in the flexible intra oral member,transferral of at least part of the oral fluid from the flexible intra oral member into the sample container by activation of the sub-atmospheric pressure of the evacuated sample container.2. The method according to claim 1 , wherein the collecting member is configured such that a pressure inside the flexible intra oral member when present in the oral cavity is provided which enables the collection of oral fluids within the flexible intra oral member.3. The method according to wherein the sub-atmospheric pressure of the evacuated sample container is activated after a sufficient volume of oral fluid has been collected inside the flexible intra oral member.4. The method according to claim 1 , wherein the sealed evacuated sample container is activated by penetration of the seal.5. The method according to claim 4 , wherein the seal is penetrated by an axial movement of the sealed evacuated sample container.6. A device configured for the collection of oral fluids according to the method of claim claim 4 , comprising at least:a collecting member, comprising a flexible intra oral member with at least one opening and a rigid member, the flexible intra oral member comprising at least one opening,a sealed evacuated sample container, whereinthe collecting member is configured such that a pressure inside the flexible intra oral member when present ...

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Номер записи: 88
24-03-2016 дата публикации

MEDICAL SPECIMEN COLLECTION SYSTEM

Номер: US20160081669A1
Автор: JR. Timothy, LOWNEY
Принадлежит:

Systems for collecting medical specimens are generally described. The systems may be configured to, among other things, improve the ease of specimen collection and increase the ability of a patient to provide the highest quality sample with no loss of specimen. A system may include a collection container and a specimen collection portion removably coupled to the collection container. A system may be configured to include a base portion and a specimen collection portion extending from the base portion, the base portion and the specimen collection portion being a single monolithic piece and arranged to form a substantially bent cylinder shape. A system may include a base portion and a specimen collection portion extending from the base portion formed from a single monolithic piece in which the base portion has a substantially cylindrical shape and the specimen collection portion has a substantially funnel shape. 1. A medical specimen collection system , comprising:a collection container,a specimen collection portion in fluid communication with the collection container, the specimen collection portion being configured to receive a fluid medical specimen from a patient and to facilitate a flow of the fluid medical specimen into the specimen container, wherein the specimen collection portion has a width of about 5 centimeters to about 10 centimeters and a height of about 5 centimeters to about 10 centimeters.2. The medical specimen collection system of claim 1 , wherein the specimen collection portion is in fluid communication with a conduit configured to direct the fluid medical specimen into the specimen container.3. The medical specimen collection system of claim 1 , wherein the specimen collection portion is configured to be removably coupled to the specimen container.4. The medical specimen collection system of claim 1 , wherein the specimen collection portion comprises an inner surface having a surface area of about 5 centimetersto about 20 centimeters.5. The ...

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Номер записи: 89
23-03-2017 дата публикации

APPARATUSES AND METHODS FOR EXTRACTING CHEMICALS FROM BODILY CAVITIES AND BREATH

Номер: US20170079558A1
Автор: Bazemore Kathy, Bazemore Russell
Принадлежит: Volatile Analysis Corporation

A chemical extraction apparatus has absorbent material for absorbing or adsorbing volatile chemicals from a breath of a user. The chemical extraction apparatus is positioned within such that breaths from the user flow over the absorbent material thereby causing volatile chemicals in the breaths to absorb or adsorb into the absorbent material. The absorbent material is then analyzed to determine the amount of chemicals absorbed or adsorbed into the absorbent material. Based on such analysis, various diseases or conditions can be detected or diagnosed. 117-. (canceled)18. A pacifier , comprising:a support element; anda nipple for insertion into an oral cavity of a user, the nipple coupled to the support element and having absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of the user.19. The pacifier of claim 18 , further comprising a handle coupled to the support element.20. The pacifier of claim 18 , wherein the nipple has a cavity claim 18 , and wherein the absorbent material is within the cavity.21. The pacifier of claim 20 , wherein the nipple has a hole for allowing the breaths to pass through the hole into the cavity.22. The pacifier of claim 21 , wherein the absorbent material is attached to an inner wall of the nipple by an arm extending from the inner wall.23. A method claim 21 , comprising:providing a pacifier having a nipple, wherein the nipple has absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of a user;inserting a nipple of a pacifier into an oral cavity of the user such that the trace levels of the volatile chemicals are absorbed or adsorbed into the absorbent material;analyzing the absorbent material;identifying the trace levels of the volatile chemicals based on the analyzing; anddiagnosing a condition of the user based on the identified trace levels of the volatile chemicals.24. The method of claim 23 , wherein the nipple has a cavity claim 23 , and wherein the ...

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Номер записи: 90
14-03-2019 дата публикации

Biological fluid testing device

Номер: US20190078982A1
Автор: Roy G. Whiteside, JR.
Принадлежит: Individual

A biological fluid testing and collection device includes a container, a cartridge, and a collection stick. The cartridge is configured to rest within the container and seat itself just above a reservoir at the bottom of the container. The collection stick acquires a liquid sample on a pad and is inserted within the container inside the internal cartridge. The pad is compressed against a screen on the cartridge to release the liquid sample. The liquid sample falls through apertures in the cartridge and collects centrally within the reservoir. The testing strips are located externally around the cartridge and contact the reservoir surface. The testing strips are routed to point centrally in the reservoir and extend beneath the pad. A port in communication with the reservoir may be used to permit the removal of liquid sample within the reservoir without removal of the collection stick.

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Номер записи: 91
14-03-2019 дата публикации

SYSTEMS, COMPOSITIONS, AND METHODS FOR TARGETED CHALLENGE AND IDENTIFICATION OF GUT MICROBIOTA

Номер: US20190079073A1
Автор: Hyde Roderick A., McKnight Gary L., Sweeney Elizabeth A.
Принадлежит:

Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A system embodiment includes, but is not limited to, a composition including the challenge agent; and an emissions analysis device including a body structure defining an orifice configured to receive a biofluid; a sensor operably coupled to the orifice and configured to detect at least one analyte from the biofluid and generate one or more sense signals, the one or more sense signals associated with the measurable response; circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals associated with at least one targeted microbe. 1. A system , comprising: a challenge agent configured to elicit a measurable response by the at least one targeted microbe at the specific site in the gut, the measurable response detectable in a bodily gaseous emission; and', 'a controlled release system encompassing at least a portion of the challenge agent, the controlled release system configured to access the specific site of the gut; and, 'a composition for detecting at least one targeted microbe in a specific site of the gut, the composition including'} a body structure defining an orifice configured to receive the bodily gaseous emission;', 'a sensor operably coupled to the orifice and configured to detect at least one analyte from the bodily gaseous emission and generate one or more sense signals, the one or more sense signals associated with the measurable response;', 'circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and', 'a reporter operably coupled to the circuitry and configured to generate one or more communication ...

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Номер записи: 92
25-03-2021 дата публикации

SAMPLE COLLECTION KIT INCLUDING CAP HAVING SELECTIVELY OPENABLE DIAPHRAGM VALVE

Номер: US20210085296A1
Автор: Johnson Neil Jeremy
Принадлежит:

A biological sample collection system can include a sample collection vessel having a closed first end and an open second for receiving a biological sample. The system can additionally include a sealing cap configured to associate with the sample collection vessel, a reagent chamber secured within an interior space of the sealing cap and retaining a measure of sample preservation solution, a shim circumferentially associated with a proximal end of the reagent chamber and spanning the distance between the reagent chamber and the interior sidewall of the sealing cap, and a plug having a diaphragm configured to selectively engage the shim and form a seal for retaining the sample preservation solution within the reagent chamber. Associating the sealing cap with the sample collection vessel displaces the diaphragm from the shim and breaks the seal formed therebetween, opening a fluid path between the reagent chamber and the sample collection chamber. 1. A biological sample collection system , comprising:a sample collection vessel spanning between a closed first end and a second end having an opening to receive a biological sample into a sample collection chamber defined within the sample collection vessel;a sealing cap configured to associate with the second end of the sample collection vessel;a reagent chamber configured to secure within an interior space defined by the sealing cap and to retain a measure of sample preservation solution therein;a shim configured to circumferentially associate with a proximal end of the reagent chamber and to span a distance between the proximal end of the reagent chamber and an interior sidewall of the sealing cap;a plug having a diaphragm sized and shaped to fit within the opening of sample collection vessel and configured to selectively engage the shim and form a seal to retain the measure of sample preservation solution within the reagent chamber,wherein associating the sealing cap with the sample collection vessel displaces the ...

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Номер записи: 93
25-03-2021 дата публикации

DEVICES AND METHODS FOR AIDING CONCEPTION

Номер: US20210085297A1
Автор: MURALI Vivek, PANDI CHELVAM Shruthi, SINA RAJA Prusothman M., Tee Chee Keong, XU Zongyuan
Принадлежит:

A conception aid for assisting in natural conception may include a platform configured for placement in a vaginal canal, wherein the platform comprises one or more capturing elements configured to collect semen. A method of aiding conception may include providing a conception aid device including one or more capturing elements, collecting semen with the one or more capturing elements wherein the one or more capturing elements is configured to contain the collected semen on the device, and positioning the device in a vaginal canal. 1. A conception aid , comprising:a platform configured for placement in a vaginal canal, wherein the platform comprises at least one preformed curve along a longitudinal axis between a proximal portion and a distal portion of the platform,wherein the platform comprises one or more capturing elements configured to collect semen, andwherein the at least one preformed curve is configured to remain against a vaginal wall when the conception aid is within the vaginal canal so as to prevent flowback of captured semen towards the distal portion of the platform.2. The conception aid of claim 1 , wherein the platform has a width tapering along the longitudinal axis between the proximal portion and the distal portion of the platform.3. The conception aid of claim 1 , wherein the conception aid further comprises an extending member coupled to the distal portion of the platform.4. The conception aid of claim 3 , wherein the conception aid has a length such that when the platform is placed within the vaginal canal claim 3 , the proximal portion of the platform is positioned proximate a cervical opening and at least a portion of the extending member is external to the vaginal canal.5. The conception aid of claim 3 , wherein the extending member is angled relative to the platform.6. The conception aid of claim 3 , wherein the extending member comprises a flared shape at a distal portion of the extending member.7. The conception aid of claim 3 , further ...

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Номер записи: 94
29-03-2018 дата публикации

WEARABLE APPARATUS ATTACHING ON TOOTH AND THE SENSING DEVICE FIXING AT TOOTH

Номер: US20180085059A1
Автор: LEE Jin Kyun
Принадлежит:

Disclosed is a tooth-attach wearable device. The tooth-attach wearable device includes a body configured to attach to a tooth; a sensor device provided to the body, and configured to sense biometric information of a patient; and a communication controller provided to the body, and configured to store the biometric information sensed at the sensor device as data, and to transmit the stored data. 1. A tooth-attach wearable device , the wearable device comprising:a body configured to attach to a tooth;a sensor device provided to the body, and configured to sense biometric information of a user; anda communication controller provided to the body, and configured to store the biometric information sensed at the sensor device as data, and to transmit the stored data.2. The wearable device of claim 1 , wherein the sensor device comprises:a sensor head configured to contact with a tongue or gums of the user or be exposed inside the oral cavity, and to sense the biometric information of the user by sensing the saliva or a temperature of the user; anda sensor chip configured to couple with the sensor head.3. The wearable device of claim 2 , wherein at least one of a thermoelement claim 2 , a piezoelectric element claim 2 , a chemical substance detection element claim 2 , and a marker sensor is provided to the sensor head.4. The wearable device of claim 1 , wherein the communication controller comprises:a data storage configured to store the biometric information of the user sensed at the sensor device as data; anda data transmitter configured to remotely transmit the data stored in the data storage.5. The wearable device of claim 4 , further comprising:a monitoring device configured to display the data transmitted from the data transmitter.6. A tooth-attach wearable device having a tooth attachment corresponding to a shape of a tooth claim 4 , the wearable device comprising:a sensor head configured to couple with one surface of the tooth attachment, to be exposed inside the ...

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Номер записи: 95
21-03-2019 дата публикации

Device for assaying analytes in bodily fluids

Номер: US20190083069A1
Автор: Leslie Wilson, Matthias W. Engel, Paul Johnson
Принадлежит: EXPRESS DIAGNOSTICS INT'L Inc

A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. The sampling element can include an indicator strip for determining whether the amount of liquid sample sufficient for carrying out an assay.

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Номер записи: 96
21-03-2019 дата публикации

ORAL SUCTION DEVICE

Номер: US20190083731A1
Автор: Cole Jeptha N., Mclain Nina E.
Принадлежит:

An oral suction device includes a suction catheter having a suction portion at a first end, a shell surrounding the suction portion, and a suction tubing connector on a second end opposite the first end. The shell includes a hydrogel. 1. An oral suction device , comprising:a suction catheter having a suction portion at a first end,a shell surrounding the suction portion, anda suction tubing connector, on a second end opposite the first end,wherein the shell comprises a hydrogel.2. The oral suction device of claim 1 , further comprising a sponge surrounding the suction portion claim 1 , wherein the shell surrounds the sponge.3. The oral suction device of claim 2 , wherein the sponge is radiopaque.4. The oral suction device of claim 1 , wherein the hydrogel comprises a polymer claim 1 , water and a salt.5. The oral suction device of claim 4 , wherein the salt is sodium chloride.6. The oral suction device of claim 1 , wherein the suction portion has a length of 2.5 to 30 cm.7. The oral suction device of claim 1 , wherein the oral suction device is sterile.8. The oral suction device of claim 1 , further comprising a retention connector attached to the suction catheter.9. The oral suction device of claim 8 , wherein the retention connector is a C-clip.10. The oral suction device of claim 1 , wherein the hydrogel comprises at least one member selected from the group consisting of polyacrylamide; agar-agar; polyvinyl pryrrolidone; silicone hydrogels; and polymers and copolymers of 2-hydroxyethylmethacrylate claim 1 , glyceryl methacrylate claim 1 , methyl methacrylate claim 1 , N-vinyl pyrrolidone claim 1 , N-vinyl-2-pyrrolidone claim 1 , 2-methacryloyloxyethyl phosphorylcholine claim 1 , ethoxyethyl methacrylate and methacrylic acid.11. The oral suction device of claim 1 , wherein the hydrogel comprises polyvinyl pyrrolidone claim 1 , polyethylene glycol claim 1 , agar-agar and water.12. The oral suction device of claim 1 , wherein the hydrogel is impregnated with an ...

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Номер записи: 97
02-04-2015 дата публикации

SYSTEMS AND METHODS FOR PARENTERALLY PROCURING BODILY-FLUID SAMPLES WITH REDUCED CONTAMINATION

Номер: US20150094615A1
Автор: Patton Richard G.
Принадлежит:

The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media. 120.-. (canceled)21. A method of using a sample procurement device for obtaining bodily-fluid samples from a patient , the sample procurement device including a needle having a lumen configured for insertion into the patient , a first reservoir configured to be fluidically coupled to the needle , and a second reservoir configured to be fluidically coupled to the needle , the method comprising:inserting the needle into the patient;establishing fluid communication between the needle and the first reservoir;receiving from the patient a first volume of bodily-fluid into the first reservoir, the first volume of bodily-fluid being greater than the volume of the lumen of the needle and less than 5 ml;establishing fluid communication between the needle and a second reservoir,receiving from the patient a second volume of bodily-fluid into the second reservoir.22. The method of claim 21 , further comprising:after the first volume of bodily-fluid has been received into the first reservoir, fluidically isolating the first reservoir from the needle.23. The method of claim 22 , whereby fluidically isolating the first reservoir from the needle sequesters microbes present in the first volume of bodily-fluid claim 22 , thereby reducing contamination in the second volume of bodily-fluid received from the patient.24. The method of claim 21 , ...

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Номер записи: 98
05-05-2022 дата публикации

SYSTEMS AND INTERFACES FOR BLOOD SAMPLING

Номер: US20220133192A1
Автор: Brancazio David
Принадлежит: YourBio Health, Inc.

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood from subjects. In one aspect, the present invention is directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a substance transfer component (for example, one or more needles or microneedles) and a reduced pressure or vacuum chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some embodiments, the device may contain a “snap dome” or other deformable structure, which may be used, at least in part, to urge or move needles or other suitable substance transfer components into the skin of a subject. In some cases, for example, the device may contain a flexible concave member and a needle mechanically coupled to the flexible concave member such that the needle may be urged or moved into the skin using the flexible concave member. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

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Номер записи: 99
05-05-2022 дата публикации

SWAB

Номер: US20220133283A1
Автор: Ahmed Hafiz Imtiaz, Hasan Zahra, Muqeet Muhammad Abdul, Sayani Saleem
Принадлежит:

A swab is described that includes a handle, a connecting rod including a ring groove, and a head having a shape of at least one of flagella or pilus. The head includes one or more channels configured to collect sample (e.g., specimen) from an anatomical part of a patient. The one or more channels can store the sample while additional sample is being collected. The head has an end that is convex. The handle includes a circular disc to hold the swab. The connecting rod is configured to be broken at the ring groove when pressure is applied to bend the swab. The handle, the connecting rod, and the head form/are a single integrated structure and are inseparable without breaking the single integrated structure. The anatomical part can be a nose or a throat. Related apparatuses, systems, techniques, methods and articles are also within the scope of this disclosure.

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Номер записи: 100