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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 2530. Отображено 100.
02-02-2012 дата публикации

Ultrasound device for medical applications

Номер: US20120029352A1
Автор: Michael Clossen-Von Lanken Schulz
Принадлежит: SIEMENS AG

An ultrasound device for medical application has a transducer formed by a number of transducer elements. The transducer elements are carried on a flexible support that allows the transducer elements to be configured to an examination subject. A measurement device determines, for each transducer element, a distance or a rotation thereof with respect to a reference point. The reference point can be a point that is physically a part of the ultrasound device, or can be a virtual reference point.

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Номер записи: 1
08-03-2012 дата публикации

Method and system for ultrasound treatment with a multi-directional transducer

Номер: US20120059288A1
Автор: Michael H. Slayton, Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.

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Номер записи: 2
05-04-2012 дата публикации

Hands-Free Operator-Independent Transcranial Ultrasound Apparatus and Methods

Номер: US20120083718A1
Автор: Anthony J. Alleman, Randal Lee RADFORD, William Barnard
Принадлежит: Cerevast Therapeutics Inc

Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.

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Номер записи: 3
19-04-2012 дата публикации

Ultrasound transducer and cooling thereof

Номер: US20120095371A1
Автор: Ariel Sverdlik, Or Shabtay
Принадлежит: Cardiosonic Ltd

An ultrasonic transducer device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for tissue ablation, the power beam being produced by vibration over the body of the transducer and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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Номер записи: 4
24-05-2012 дата публикации

Ultrasound detecting device having function of confirming irradiation position, and method thereof

Номер: US20120130240A1
Автор: Atsushi Asahina, Jun Takeda, Naoko Sakamoto
Принадлежит: Teijin Pharma Ltd

Provided is an ultrasound fracture detection device capable of accurately irradiating an ultrasound pulse to a target object, the device being characterized by being provided with an ultrasound wave irradiating transducer, a signal receiving transducer which receives a reflected wave of an ultrasound wave irradiated from the ultrasound wave irradiating transducer, a signal, storage unit which stores a received signal, and a display unit which displays an analysis program that analyzes a stored signal, a determination program that performs determination from the result of the analysis and/or performs determination from the stored signal, and the result of the analysis and/or the result of the determination, wherein the determination program performs the determination using that information relating to the received signal varies depending on the reflector within a living organism.

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Номер записи: 5
31-05-2012 дата публикации

Method and apparatus for treatment of adipose tissue

Номер: US20120136282A1
Автор: Avner Rosenberg, Michael Kreindel, Shimon Eckhouse
Принадлежит: SYNERON MEDICAL LTD

The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

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Номер записи: 6
05-07-2012 дата публикации

Mr imaging guided theraphy

Номер: US20120172708A1
Автор: Ajay Anand, Balasundara Iyyavu Raju, Gösta Jakob Ehnholm
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The invention relates to a therapeutic system which comprises an ultrasound therapy unit ( 1, 518 ) arranged to insonify at least a portion of a body ( 2, 508 ) of a patient with high intensity ultrasound and a MR imaging unit ( 3, 500 ) arranged to acquire MR signals from the portion of the body ( 2, 508 ) and to reconstruct a thermographic MR image from the MR signals. It is an object of the invention to enable MR guided high intensity focused ultrasound (HIFU) treatment, in which temperature values within critical anatomic regions containing fat can be monitored. The invention proposes that the therapeutic system further comprises an ultrasound diagnostic unit ( 5, 518 ) which is arranged to acquire ultrasound signals from the portion of the body ( 2, 508 ) and to derive at least one local temperature value from the ultrasound signals.

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Номер записи: 7
09-08-2012 дата публикации

Ultrasound power supply for an ultrasound transducer

Номер: US20120203098A1
Автор: Balasundara Iyyavu Raju, Shiwei Zhou, Shunmugavelu Sokka
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An ultrasound power supply ( 100 ) adapted for supplying electrical power for driving an ultrasound transducer ( 202, 702 ) in contact with a subject ( 208 ), wherein the ultrasound power supply comprises:—a communications interface ( 102 ) adapted for receiving a first temperature measurement of a first volume ( 211, 318 ) of the subject and a second temperature measurement of a second volume ( 214, 320 ) of the subject;—a controller ( 108 ) adapted for modulating the output of electrical power for driving the ultrasound transducer such that via ultrasonic heating by the ultrasound transducer: a. the first temperature measurement is maintained above a first predetermined threshold, b. the first temperature measurement is maintained below a second predetermined threshold, and c. the second temperature measurement is maintained below a third predetermined threshold; and wherein the first predetermined threshold is above the third predetermined threshold.

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Номер записи: 8
23-08-2012 дата публикации

Medical device

Номер: US20120215136A1
Автор: JIN Zhang, John B. Schneider, Richard H. Pearce
Принадлежит: Smith and Nephew Inc

A modular medical device includes a core module housing. The core module housing includes a treatment module interface configured to couple to any one of a plurality of treatment modules, and each of the plurality of treatment modules includes a treatment assembly configured to apply a medical treatment. The core housing module contains one or more processing devices coupled to the treatment module interface and configured to determine which particular treatment module, from the plurality of treatment modules, is coupled to the treatment module interface. The one or more processing devices are configured to select, based on the determination, a set of control instructions for the particular treatment module from a plurality of control instructions, and control the particular treatment module using the selected control instructions such that the treatment assembly of the particular treatment module applies the medical treatment for which the treatment assembly is configured.

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Номер записи: 9
20-09-2012 дата публикации

Nerve treatment system

Номер: US20120238919A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

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Номер записи: 10
25-10-2012 дата публикации

Energetic modulation of nerves

Номер: US20120271171A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.

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Номер записи: 11
25-10-2012 дата публикации

Apparatus and Method for Ablating Tissue

Номер: US20120271334A1
Автор: Benjamin Pless, David A. Gallup, Jack E. Ulstad, Jr., John E. Crowe, Jonathan L. Podmore, Matthias Vaska, Roxanne L. Richman, Scott C. Anderson, Timothy Ciciarelli
Принадлежит: Individual

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

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Номер записи: 12
03-01-2013 дата публикации

Low-profile ultrasound transducer

Номер: US20130006153A1
Автор: George K. Lewis, Jr.
Принадлежит: ZETROZ LLC

The present invention relates to a low-profile ultrasound transducer. The low-profile ultrasound transducer includes a piezoelectric component operative to receive a driving signal from an energy generating module and to emit the driving signal as ultrasonic energy. The piezoelectric component has a front surface and a back surface, and the energy generating module includes a plurality of electronic components. The low-profile ultrasound transducer also includes a lens component directly or indirectly deposited on the front surface of the piezoelectric component. The lens component includes a lens portion and a support portion. The lens portion of the lens component is configured to control the direction and wave pattern of the ultrasonic energy emitted from the piezoelectric component. The support portion of the lens component is configured to hold the piezoelectric component in place and to provide a chamber for housing at least one electronic component of the energy generating module. Methods of use and related devices are also disclosed.

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Номер записи: 13
10-01-2013 дата публикации

Methods and systems for ultrasound treatment

Номер: US20130012842A1
Автор: Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment are provided. Acoustic energy, including ultrasound, can serve as input energy to a mask with apertures, such apertures acting as secondary acoustic sources to create a modulated output acoustic energy in a treatment region and treatment effects. Under proper control output energy can be precisely placed and controlled in tissue. In some embodiments, methods and systems are configured for ultrasound treatment based on creating an output energy distribution in tissue. In some embodiments, methods and systems are configured based on creating an output temperature distribution in tissue.

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Номер записи: 14
24-01-2013 дата публикации

Ultrasonic transducer

Номер: US20130023801A1
Автор: Chunliang Zhao, Deping Zeng, Fangwei Ye, Guihua Xu, Hua Wang, Sanyong Li, Xiaobo Gong, Zhibiao Wang
Принадлежит: Chongqing Haifu Hifu Technology Co Ltd

An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located. The ultrasonic transducer not only can be provided with a large ultrasonic emitting area and a great focusing gain that render the energy of the ultrasonic focus enhanced dramatically, but also can be free from the influence of work frequency of an ultrasonic source.

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Номер записи: 15
07-02-2013 дата публикации

Sparker Array Source

Номер: US20130033968A1
Автор: John Gallagher, Michael Grapperhaus, Raymond B. Schaefer, Robin O. Cleveland
Принадлежит: Phoenix Science and Tech Inc

A sparker array includes a plurality of sparker sources of sound and light emissions, the plurality of sparker sources arranged in a geometric pattern with respect to a region, the array configured to deliver a maximal acoustic output to the region. Sparker sources may include reflectors. A single electrical source to drive a sparker array may be employed. A sparker system may include two or more sparker arrays. A time delay may be employed to trigger electrical circuits of the sparker arrays. Sparker arrays may be used to deliver shock waves with increased operational life, consistency and efficacy for specific applications.

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Номер записи: 16
07-03-2013 дата публикации

Dual-Mode Piezocomposite Ultrasonic Transducer

Номер: US20130060140A1
Автор: Yegor Sinelnikov
Принадлежит: Individual

A compact, high power, dual mode, emitting and receiving ultrasound transducer and method for applying ultrasonic energy within a living subject and for monitoring the effects it induces in tissue comprises a set of piezoelectric polymeric transducer elements and a set of piezoelectric ceramic elements, bonded together. The polymeric transducer elements have electrodes enabling their use for low power diagnostic imaging interrogation of the tissue and the ceramic transducer elements have electrodes enabling their use for high power therapy applications.

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Номер записи: 17
25-04-2013 дата публикации

Reflectance-facilitated ultrasound treatment and monitoring

Номер: US20130103028A1
Автор: Liat Tsoref, Michael Kardosh, Yossi Gross
Принадлежит: Liat Tsoref, Michael Kardosh, Yossi Gross

Apparatus comprising an ultrasound ablation system ( 10 ), which comprises a reflection-facilitation element ( 12 ), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool ( 20 ), which comprises at least one ultrasound transducer ( 40 ) configured to be positioned within a heart chamber of the subject. The ultrasound transducer ( 40 ) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

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Номер записи: 18
02-05-2013 дата публикации

Targeted inhibition of physiologic and pathologic processes

Номер: US20130110012A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

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Номер записи: 19
13-06-2013 дата публикации

Catheter balloon methods and apparatus employing sensing elements

Номер: US20130150693A1
Автор: Bassel de Graff, Cliff Liu, Kevin Dowling, Lauren Klinker, Robert D'Angelo, Roozbeh Ghaffari, Stephen P. Lee, Yung-Yu Hsu
Принадлежит: Individual

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

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Номер записи: 20
01-08-2013 дата публикации

System and method for determining the optimum size of an ultrasonic wave generation device

Номер: US20130197400A1
Автор: Fabrizio Romano, Florent Aptel, Laurent Farcy
Принадлежит: EYE TECH CARE

The present invention relates to a method for determining a probe model for treating an eye pathology, from among a plurality of different probe models, each probe including a cone-shaped ring including a proximal end ( 11 ) intended to be in contact with one eye ( 4 ) of a patient and a distal end ( 12 ) intended to receive means for generating ultrasonic waves ( 2 ), the method comprising a step for receiving at least one measurement of a biometric parameter of the eye, and a step for determining the optimum probe model according to each biometric parameter.

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Номер записи: 21
08-08-2013 дата публикации

Ultrasound transceiver and cooling thereof

Номер: US20130204167A1
Автор: Ariel Sverdlik, Or Shabtay
Принадлежит: Cardiosonic Ltd

An ultrasonic transceiver device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for thermal tissue damage, the power beam being produced by vibration over the body of the transceiver and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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Номер записи: 22
15-08-2013 дата публикации

Methods for face and neck lifts

Номер: US20130211258A1
Автор: Inder Raj S. Makin, Michael H. Slayton, Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

Methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Methods of lifting sagging tissue on a face and/or neck are described.

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Номер записи: 23
12-12-2013 дата публикации

Bifurcated catheter

Номер: US20130331921A1
Автор: Gary Roubin
Принадлежит: Individual

Systems and methods are disclosed for a bifurcated catheter, and more particularly, to denervation of arterial nerves using a bifurcated catheter. In embodiments, the catheter comprises, for example, a catheter shaft bifurcated into a first catheter energy member and a second catheter energy member, wherein the first catheter energy member comprises a first transducer and the second catheter energy member comprises a second transducer, and wherein the first and second transducers are configured to cause denervation of an arterial nerve of the patient.

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Номер записи: 24
19-12-2013 дата публикации

Calculating the speed of ultrasound in at least two tissue types

Номер: US20130338485A1
Автор: Charles Mougenot, Gösta Jakob Ehnholm, Iipo Asko Julius Koskela, Max Oskar KÖHLER
Принадлежит: Koninklijke Philips NV

A medical apparatus ( 400 ) comprising an ultrasound transmitter ( 444, 602 ) and receiver ( 446, 604 ) system ( 600 ) for acquiring ultrasound data ( 476 ) descriptive of the speed of ultrasound ( 304, 306 ) along at least two paths ( 606, 1114 ). The medical apparatus further comprises a medical imaging system ( 402 ) for acquiring medical image data ( 468 ) and a memory ( 464 ) containing instructions ( 490, 492, 494, 496, 498, 500, 502, 504 ) that causes the processor to acquire ( 100, 200 ) the medical image data. The instructions further cause the processor to acquire ( 102, 202 ) the ultrasound data. The instructions further cause the processor to segment ( 104, 204 ) the medical image data into at least two tissue types ( 434, 436, 610, 612, 708, 710 ). The instructions further causes the processor to determine ( 106, 206 ) at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate ( 108, 208 ) the speed of ultrasound in the at least two tissue types.

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Номер записи: 25
23-01-2014 дата публикации

Transoesophageal device using high intensity focused ultrasounds for cardiac thermal ablation

Номер: US20140024923A1
Автор: Cyril Lafon, Elodie Constanciel, Jean-Yves Chapelon
Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM

The present invention relates to a probe that comprises a piezoelectric therapy transducer having an acoustic axis BB′, and an imaging transducer having an imaging plane, in which the therapy transducer and imaging transducer are mounted in a head which is itself connected to a guide. More particularly, the therapy transducer is in a form of a truncated cup and has a spherical concave front face for emitting ultrasonic waves focused on a focal point, a rear surface and the therapy transducer is truncated alone two parallel lanes such that a length d 1 , a width t and a longitudinal direction are provided; the therapy transducer is a 1D annular phased array transducer and the imaging transducer is a multiplane transducer having a rotation axis corresponding to the acoustic axis of the therapy transducer whereby the focal point of the therapy transducer is comprised in the imaging plane of the imaging transducer, said imaging transducer being fixed to the therapy transducer

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Номер записи: 26
06-02-2014 дата публикации

Acoustic palpation using non-invasive ultrasound techniques for identification of target sites and assessment of chronic pain disorders

Номер: US20140039279A1
Автор: Abbi M McClintic, Jeffrey G. Jarvik, Michael Gofeld, Michel Kliot, Pierre Mourad, Robert C.A. Frederickson, Trevor C. Dickey
Принадлежит: PhysioSonics Inc, UNIVERSITY OF WASHINGTON

Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.

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Номер записи: 27
06-02-2014 дата публикации

Energetic modulation of nerves

Номер: US20140039479A1
Автор: Michael Gertner
Принадлежит: Kona Medical, Inc.

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

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Номер записи: 28
27-02-2014 дата публикации

Tissue treatment and monitoring by application of energy

Номер: US20140058294A1
Автор: Gideon Meiry, Leonid KUSHKULEY, Liat Tsoref, Michael Kardosh, Yaron Assaf, Yossi Gross
Принадлежит: Rainbow Medical Ltd

Apparatus is provided, which includes at least one ultrasound transducer. The ultrasound transducer is configured to be positioned within a lumen of a subject and to ablate tissue surrounding a wall of the lumen without ablating the wall of the lumen, by focusing ultrasound energy on a focal zone that is outside of the wall of the lumen. A transluminal delivery tool is configured to position the ultrasound transducer in the lumen, and a control unit is configured to drive the ultrasound transducer. Other embodiments are also described.

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Номер записи: 29
03-04-2014 дата публикации

Ultrasound neuromodulation treatment of schizophrenia

Номер: US20140094719A1
Автор: David J Mishelevich
Принадлежит: Individual

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat schizophrenia. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

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Номер записи: 30
03-01-2019 дата публикации

PHASED ARRAY TRANSDUCER WITH COUPLING LAYER FOR SUPPRESSION OF GRATING LOBES

Номер: US20190000416A1
Автор: Hynynen Kullervo Henrik
Принадлежит:

An ultrasound phased array transducer is disclosed that achieves suppression of grating lobes through the incorporation of a coupling layer, where the coupling layer is positioned adjacent to the phased array transducer such that an ultrasound beam propagates through the coupling layer prior to encountering a propagation medium. The phased-array elements may be provided such that one or both of the array pitch and a lateral extent of each ultrasound transducer element is larger than half of the ultrasound wavelength in the propagation medium. Grating lobes within the coupling layer and the propagation medium may be reduced or suppressed by selecting a coupling material having a speed of sound that exceeds that of the propagation medium. The coupling layer may have a thickness sufficient for the generation of a wavefront, and the coupling layer may be formed from a viscous or viscoelastic material. 1. A phased array ultrasound transducer comprising:an array of ultrasound transducer elements configured for emitting a phased-array ultrasound beam therefrom, wherein each ultrasound transducer element has an associated ultrasound emission wavelength in soft tissue, wherein a lateral extent of each transducer element is larger than half of the ultrasound wavelength in soft tissue; anda coupling layer contacting said array of ultrasound transducer elements, said coupling layer having a speed of sound greater than the speed of sound of soft tissue and a thickness sufficient for the generation of a wavefront therein, thereby reducing or suppressing the generation of grating lobes.2. The phased array ultrasound transducer according to wherein said coupling layer has a speed of sound that is sufficiently high to suppress the generation of grating lobes.3. The phased array ultrasound transducer according to wherein a ratio of the lateral extent of each transducer element to half of the ultrasound wavelength in soft tissue is less than the ratio of the speed of sound of the ...

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Номер записи: 31
04-01-2018 дата публикации

Automated ultrasound apparatus and method for noninvasive vessel recanalization treatment and monitoring

Номер: US20180001114A1
Автор: Clayton T. LARSEN, Rhodemann Li
Принадлежит: Vesselon Inc

An apparatus and method for automatically lysing a clot to recanalize vessels using ultrasound, with or without nanoparticles, microbubbles, thrombolytic drugs or other agents, is described herein. At least one ultrasound transducer with a specified geometry, bandwidth and/or transmit pulse characteristics can generate a more uniform 3-dimensional volume of defocused acoustic energy into a target area of the body. When an agent (such as, but not limited to, microbubbles) is used to lyse a clot, a certain level of ultrasound energy may be desired in order to effect certain actions or states of the agent. Bone attenuation may present an issue inhibiting sufficient ultrasound energy from reaching the agent in order to attain the desired agent action. The relative patient dimensions and location of the clot may also present an issue.

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Номер записи: 32
05-01-2017 дата публикации

METHOD FOR OPERATING A DEVICE FOR TREATMENT OF A TISSUE AND DEVICE FOR TREATMENT OF A TISSUE

Номер: US20170001042A1
Автор: Lacoste Francois
Принадлежит: Theraclion SA

A method of operating a device () for treatment of a tissue () of a living being and such a device () including a transducer () comprising at least two subtransducers (″), each for emitting a sub-beam (″) of ultrasound waves, preferably high intensity focused ultrasound waves, for irradiating the tissue (). Each of the sub-beams (″) is focused on or focusable onto a focal point (F). In order to reduce skin burns, the intersection Area (A) of a skin surface () for each sub-beam (″) is evaluated and a power (P) and/or a duration (t) of the irradiation, for every sub-transducer (″), is determined as a rate of the total power (P) or duration (t) depending from the evaluated intersection area (A). 116-. (canceled)17. A method of operating a device for treatment of a tissue of a living being , the device comprising:a transducer comprising at least two sub-transducers, each for emitting a sub-beam of ultrasound waves for irradiating the tissue, and each of the sub-beams being focused on or focusable onto a focal point;wherein the method includes the following steps:positioning the transducer such that at least one focal point of a sub-beam is located within the tissue to be treated;defining a total power and a duration of the irradiation to be delivered to the tissue;evaluating an intersection area of a skin surface with each sub-beam; anddetermining at least one of the power and the duration of the irradiation for every sub-transducer as a rate of the total power or duration depending from the evaluated intersection area.18. The method according to claim 17 , wherein the intersection area is evaluated taking into consideration a sub-beam area at a sub-transducer surface and a distance between skin surface and the sub-transducer surface.19. The method according to claim 18 , wherein the distance between skin surface and the sub-transducer surface is determined by means of A-mode echography.20. The method according to claim 17 , wherein if the intersection area is below a ...

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Номер записи: 33
03-01-2019 дата публикации

STEERABLE HIGH-INTENSITY FOCUSED ULTRASOUND (HIFU) ELEMENTS

Номер: US20190001159A1
Автор: Chen Kailiang, Ralston Tyler S., Sanchez Nevada J., West Lawrence C., Zahorian Jaime Scott
Принадлежит: Butterfly Network, Inc.

Ultrasound devices configured to perform high-intensity focused ultrasound (HIFU) are described. An ultrasound device may include HIFU units configured to emit high acoustic intensities. Multiple ultrasound devices may be disposed on a substrate, which may be configured to be flexed so that the direction of emission of the ultrasound devices can be mechanically controlled. Additionally, or alternatively, the ultrasound beams produced by different ultrasound devices may be electronically oriented by adjusting the phases of the signals with which each element of a device is driven. For example, multiple phased arrays of ultrasound devices may be used to concentrate ultrasound energy into a desired location. In some embodiments, the time at which different ultrasound signals are emitted may be controlled, for example to ensure that the combined signal has at least a desired intensity. 1. An apparatus comprising:a substrate having a plurality of support portions including a first support portion and a second support portion, wherein the first support portion is connected to the second support portion through a coupler;a first plurality of ultrasound elements configured as high-intensity focused ultrasound (HIFU) elements and disposed on the first support portion of the substrate; anda second plurality of ultrasound elements configured as HIFU elements and disposed on the second support portion of the substrate.2. The apparatus of claim 1 , wherein the first and second plurality of ultrasound elements comprise capacitive micromachined ultrasound transducers (CMUT).3. The apparatus of claim 1 , wherein the coupler is selected from the group consisting of a hinge claim 1 , a spring claim 1 , a flexure claim 1 , a beam claim 1 , a joint and a sphere.4. The apparatus of claim 1 , further comprising a third plurality of ultrasound elements configured to receive ultrasound signals and disposed on the first support portion of the substrate.5. The apparatus of claim 4 , wherein ...

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Номер записи: 34
01-01-2015 дата публикации

Methods for thermally-induced renal neuromodulation

Номер: US20150005676A1
Автор: Benjamin J. Clark, Denise Zarins, Erik Thai, Howard R. Levin, Mark Gelfand, Nicolas Zadno
Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

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Номер записи: 35
01-01-2015 дата публикации

High intensity focused ultrasound enhanced by cavitation

Номер: US20150005756A1
Автор: Matti Oskari TILLANDER, Max Oskar KÖHLER, Shunmugavelu Sokka
Принадлежит: Koninklijke Philips NV

A medical apparatus ( 600, 700, 800, 900 ) comprising a high intensity focused ultrasound system ( 602 ) configured for generating focused ultrasonic energy ( 612 ) for sonicating within a target volume ( 620 ) of a subject ( 601 ). The high intensity focused ultrasound comprises an ultrasonic transducer ( 606 ) with a controllable focus ( 618 ). The apparatus further comprises a memory ( 634 ) containing machine executable for controlling the medical apparatus and a processor ( 628 ) for executing the instructions. Execution of the instructions causes the processor to cause ( 100, 200, 300, 400, 502 ) ultrasonic cavitations at multiple cavitation locations ( 622, 1002 ) within the target volume using the high intensity focused ultrasound system. Execution of the instructions further cause the processor to sonicate ( 102, 206, 306, 402, 504 ) multiple sonication locations ( 1004 ) within the target volume using the high intensity focused ultrasound system. The multiple sonication locations and the multiple cavitation locations are targeted by adjusting the controllable focus.

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Номер записи: 36
20-01-2022 дата публикации

ULTRASOUND DEVICE FOR FACILITATING WASTE CLEARANCE OF THE BRAIN LYMPHATIC SYSTEM

Номер: US20220016444A1
Автор: Chung Gujin, PARK Woong, Yoo Seungschik
Принадлежит:

An ultrasound device for facilitating waste clearance of the brain lymphatic system includes: a first frequency-generator generating a predetermined frequency; a first waveform modulator modulating a waveform of the frequency; a first linear amplifier amplifying the waveform; a first resonance circuit portion matching impedance of the amplified waveform; and a first ultrasound transducer coupled to the first resonance circuit portion and irradiating ultrasound toward the area of the brain of mammals, wherein the ultrasound facilitates clearance of lymphatic wastes of the brain. 1. An ultrasound device for facilitating lymphatic waste clearance of a brain lymphatic system , comprising:a first frequency-generator generating a first frequency that is of an ultrasound waveform in a band of 100 KHz to 200 KHz;a first waveform modulator modulating the waveform of the first frequency;a first linear amplifier amplifying the waveform of the first frequency;a first resonance circuit portion matching impedance of the amplified waveform of the first frequency; anda first ultrasound transducer coupled to the first resonance circuit portion and irradiating ultrasound toward a brain of mammals,wherein the ultrasound facilitates the lymphatic waste clearance of the brain.2. The ultrasound device according to claim 1 , further comprising:a second frequency-generator generating a second frequency that is of an ultrasound waveform in a band of 100 KHz to 200 KHz;a second waveform modulator modulating a waveform of the second frequency;a second linear amplifier amplifying the waveform of the second frequency;a second resonance circuit portion matching impedance of the amplified waveform of the second frequency; anda second ultrasound transducer coupled to the second resonance circuit portion and irradiating the ultrasound toward the brain of the mammals,wherein the first ultrasound transducer and the second ultrasound transducer are disposed in a circumference of the brain facing ...

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Номер записи: 37
14-01-2016 дата публикации

METHOD FOR CONFIRMING LOCATION OF FOCAL POINT, AND ULTRASONIC MEDICAL APPARATUS THEREFOR

Номер: US20160007960A1
Автор: JUN Sukhwan, KANG Kookjin, Kim Daeseung, KIM Myungdeok, SON Keonho
Принадлежит:

A method and an ultrasound medical apparatus for confirming a focal point of a high-intensity focused ultrasound are disclosed. A method of confirming a focal point, for pre-targeting a location of a high-intensity ultrasound by synchronizing the high-intensity ultrasound and an imaging ultrasound and using a reflected signal of the synchronized imaging ultrasound and high-intensity ultrasound from a focal point to which the ultrasounds are transmitted, and an ultrasound medical apparatus for implementing the method are provided. 1. An ultrasound medical apparatus , comprising:an imaging transducer including a plurality of transducer elements, each configured to transmit an imaging ultrasound to a target object;a plurality of treatment transducers, each configured to transmit a high-intensity ultrasound to a focal point corresponding to a specific focal-point information of the target object;a synchronizing unit configured to synchronize transmission times of the imaging transducer and the treatment transducers to render the imaging ultrasound and the high-intensity ultrasound to reach the focal point at the same time; andan image processing unit configured, after the imaging ultrasound and the high-intensity ultrasound are transmitted in a synchronized manner, to generate an image picture based on an echo signal received by the imaging transducer.2. The ultrasound medical apparatus according to claim 1 , wherein the synchronizing unit is configured:to establish a virtual channel for the high-intensity ultrasound by each scanline for the transducer elements of the imaging transducer, andto determine the transmission times of transmission channels for the treatment transducers based on a location of each of virtual channels and channels for the treatment transducers and the focal point, the virtual channels and the channels for the treatment transducers being collectively designated as treatment channels.3. The ultrasound medical apparatus according to claim 2 , ...

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Номер записи: 38
12-01-2017 дата публикации

LOW FREQUENCY ULTRASOUND DEVICE WITH COMPUTER-CONTROLLED MONITORING

Номер: US20170007851A1
Автор: Da Madice Dina, Da Madice Lorenzo
Принадлежит: EUROCOMPONENTS, INC.

An ultrasound device for therapeutic and aesthetic treatment is disclosed. Different types of hand probes used with the device produce different effects within biological tissues. The device can operate at low frequencies of around 20 KHz to 100 KHz. The device can be operated in continuous mode or pulsed mode with different duty cycles. Software and hardware is used to control power output of the hand probes; treatment time; to perform diagnostics of the hand probes; and to shut off ultrasound emissions in the case of abnormal or incorrect functioning of the hand probes. 1. A low frequency ultrasound device comprising:a main unit;two hand probe connection inputs; andtwo hand probes each comprising a power cord and a power cord connector connected to the main unit; andwherein the main unit comprises a display comprising information regarding one or both hand probes, a treatment protocol and performance parameters of the main unit,wherein the main unit further comprises a first printed circuit board assembly and a second printed circuit board assembly, wherein the first printed circuit board assembly and the second printed circuit board assembly share information via a CAN BUS protocol, wherein the first printed circuit board assembly comprises a display circuit board assembly, wherein the second printed circuit board assembly comprises a power circuit board assembly, wherein the power circuit board assembly responds to requests for information from the display circuit board assembly, wherein each of the first printed circuit board assembly and the second printed circuit board assembly comprises a printed circuit board and one or more of resistors, capacitors, transistors, diodes, amplifiers, resistor arrays, logic gates, semiconductors, clocks, switches, microprocessors and memory and combinations thereof, wherein the second printed circuit board assembly is programmed to regulate if amperage is sent to the hand probes and how much amperage is send to the hand ...

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Номер записи: 39
14-01-2016 дата публикации

FREQUENCY OPTIMIZATION IN ULTRASOUND TREATMENT

Номер: US20160008633A1
Автор: Vitek Shuki, Vortman Kobi, Zadicario Eyal
Принадлежит:

In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient. 1. A patient-specific frequency-optimization method for ultrasound therapy of a target within the patient , the method comprising:(a) for at least one segment of an ultrasound transducer and for each of a plurality of ultrasound frequencies within a test range, sonicating the target and measuring a parameter correlated with an amount of ultrasound energy absorbed in the target; and(b) for each said at least one segment, selecting for subsequent ultrasound therapy, among the frequencies within the test range, a frequency corresponding to a value of the measured parameter that itself corresponds to a maximum amount of ultrasound energy absorbed in the target.2. The method of claim 1 , further comprising claim 1 , following frequency selection in step (b) claim 1 , driving the at least one segment at the selected frequency and at a therapeutic energy level to thereby sonicate the target claim 1 , the therapeutic energy level exceeding an energy level of sonications applied in step (a).3. The method of claim 1 , further comprising defining a plurality of segments within the ultrasound transducer based claim 1 , at least in part claim 1 , on an anatomy of the patient.4. The method of claim 3 , wherein steps (a) and (b) are performed for each of the segments claim 3 , the method further comprising claim 3 , during ultrasound therapy claim 3 , driving the segments together claim 3 , each at its respective selected frequency.5. The method of claim 1 , wherein the plurality of frequencies within the test range is defined dynamically based claim 1 , at least in part claim 1 , on a value of the parameter measured for a previously tested frequency.6. The method of claim 1 , wherein the parameter is selected from the group consisting of a power claim 1 , an energy claim 1 , ...

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Номер записи: 40
14-01-2016 дата публикации

Catheter-based ultrasound transducers

Номер: US20160008635A1
Автор: Bruce Komadina, Emery WILLIAMS, Everette C. Burdette, Goutam GHOSHAL, Lance FRITH
Принадлежит: Individual

A multi-angular ultrasound device. Multi-angular ablation patterns are achieved by a catheter based ultrasound transducer having a plurality of transducer zones.

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Номер записи: 41
11-01-2018 дата публикации

PRESSURE WAVE TRANSDUCER

Номер: US20180008297A1
Автор: Ein-Gal Moshe
Принадлежит:

A system and method for producing pressure waves accelerating a projectile membrane in response to a pulse of force produced by a power source. The accelerating membrane delivers kinetic energy to a target membrane upon collision. Following the collision, the power source may continue to deliver additional energy to the now-in-contact membranes. The kinetic energy of the impact and the additional energy following the impact contribute to producing pressure waves by the target membrane. 1. A system comprising:a projectile membrane and a target membrane initially spaced from said projectile membrane by a gap; anda power source operative to produce a force to accelerate said projectile membrane towards said target membrane, the force causing said projectile membrane to travel over said gap and impact said target membrane with an impact force that transfers kinetic energy to said target membrane and to said target membrane, said target membrane being configured to deliver acoustic pressure pulses to an object.2. The system according to claim 1 , wherein said target membrane contacts said object.3. The system according to claim 1 , wherein said target membrane does not contact said object.4. The system according to claim 1 , further comprising a biasing device configured to move said projectile membrane back to its initial position.5. The system according to claim 1 , further comprising an array of more than one said projectile membrane and more than one said target membrane.6. The system according to claim 5 , further incorporating a sequencer operable to sequence force pulses corresponding to the more than one said projectile membrane.7. The system according to claim 1 , wherein at least one said power source produces the force to accelerate said projectile membranes towards said target membranes.8. A method comprising:providing at least one transducer, each transducer comprising a projectile membrane and a target membrane initially spaced from said projectile membrane ...

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Номер записи: 42
27-01-2022 дата публикации

ULTRASOUND ANNULAR ARRAY DEVICE FOR NEUROMODULATION

Номер: US20220023668A1
Автор: Camara Jose, David Guillaume, Firouzi Kamyar, ZHANG Yichi
Принадлежит: Liminal Sciences, Inc.

In some aspects, the described systems and methods provide for a device wearable by or attached to a person, comprising at least one annular array transducer configured to provide ultrasound radiation to at least one region of the brain of the person. In some embodiments, the annular array transducer is configured to provide the ultrasound radiation to perform non-invasive neuromodulation or neurostimulation in the at least one region of the brain of the person. 1. A device wearable by or attached to a person , comprising:at least one annular array transducer configured to provide ultrasound radiation to perform non-invasive neuromodulation in at least one region of the brain of the person.2. The device as claimed in claim 1 , wherein the device comprises circuitry configured to receive echo data from the annular array transducer and claim 1 , based on the echo data claim 1 , correct an amplitude and/or a phase of the ultrasound radiation.3. The device as claimed in claim 1 , wherein the annular array transducer is further configured to provide the ultrasound radiation to perform non-invasive neurostimulation in the at least one region of the brain of the person.4. The device as claimed in claim 1 , wherein the annular array transducer comprises a plurality of concentric elements claim 1 , wherein at least one of the plurality of concentric elements is operable to provide the ultrasound radiation.5. The device as claimed in claim 4 , wherein each of the plurality of concentric elements have substantially the same surface area.6. The device as claimed in claim 4 , wherein each of the plurality of concentric elements have substantially the same width.7. The device as claimed in claim 4 , wherein the device comprises circuitry configured to independently drive electrical energy to each element of the plurality of concentric elements.8. The device as claimed in claim 7 , wherein a time profile of the electrical energy includes a continuous wave claim 7 , a quasi- ...

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Номер записи: 43
21-01-2016 дата публикации

System and method for acoustical endodontics

Номер: US20160015478A1
Автор: Douglass Adams, Ferenc A. Jolesz, Gregory Thomas Clement, Nathan McDannold, Phillip Jason White, Tom C. PAGONIS
Принадлежит: Brigham and Womens Hospital Inc, NEWPORT ENDODONTICS PC

System and method for non-invasive sonication, through at least one of enamel and dentin, of a root-canal system of a target tooth with an externally delivered ultrasound beam, to disinfect the root-canal system while blocking a nerve associated with the tooth and removing a need for radiography to confirm the results of endodontics. The tooth does not have a physical access opening to the root canal system. When focused, the beam is oriented to expose the root-canal system to the ultrasound within the confocal range of the beam such as to concentrate the ultrasound energy within the root-canal system and to avoid irradiating teeth that are immediately adjacent to the target tooth.

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Номер записи: 44
21-01-2016 дата публикации

STIMULATION APPARATUS USING LOW INTENSITY FOCUSED ULTRASOUND FOR PAIN MANAGEMENT AND MUSCLE STRENGTHENING

Номер: US20160016012A1
Автор: CHAE Yu Seon, CHOI Kuiwon, HAN Sungmin, JUNG Hoyoung, Kim Hyung Min, KIM Jinseok, Park Jong Woong, YOUN Inchan, YUNE Tae Young
Принадлежит: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

A stimulation apparatus using low intensity focused ultrasound, which has a low intensity ultrasound focusing array having a plurality of transducers for outputting low intensity ultrasound beams, and a fixing device to which the low intensity ultrasound focusing array is attached, the fixing device being configured to fix the low intensity ultrasound focusing array to an upper body of a user. The low intensity ultrasound beams outputted from the transducers are focused to at least one focus. The focus is positioned to a spinal cord of the user or nerves around the spinal cord so that low intensity ultrasound stimulation is applied to the spinal cord or nerve cells of the nerves around the spinal cord.

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Номер записи: 45
21-01-2016 дата публикации

ULTRASOUND-BASED NEUROMODULATION SYSTEM

Номер: US20160016016A1
Автор: CHANDLER Paul, Gandionco Isidro M., MERINO Jamie, RAQUET Jacob, ROTH Austin R., Taylor Kevin
Принадлежит: RECOR MEDICAL, INC.

A neuromodulation system including a catheter has a balloon along its distal end. An ultrasound transducer positioned within an interior of the balloon can be selectively activated to emit acoustic energy radially outwardly, targeting nerve tissue and other portions of the subject anatomy. Targeted nerve tissue can be heated by the application of ultrasonic energy to neuromodulate the tissue. The system may be delivered over a guidewire. A catheter enhances fluid delivery to a distal end of the catheter while reducing an overall diameter of the catheter. The catheter comprises a guidewire lumen that is eccentric relative to a center axis of the catheter.

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Номер записи: 46
15-01-2015 дата публикации

METHOD OF THERMAL TREATMENT FOR MYOLYSIS AND DESTRUCTION OF BENIGN UTERINE TUMORS

Номер: US20150018727A1
Автор: Burdette Everette C., Deardorff Dana L., Diederich Chris J., Jacoby Alison F., Nau Will H.
Принадлежит:

A high-power ultrasound heating applicator for minimally-invasive thermal treatment of uterine fibroids or myomas. High-Intensity interstitial ultrasound, applied with minimally-invasive laparoscopic or hysteroscopic procedures, is used to effectively treat fibroids within the myometrium in lieu of major surgery. The applicators are configured with high-power capabilities and thermal penetration to treat large volumes of fibroid tissue (>70 cm) in short treatment times (3-20 minutes), while maintaining three-dimensional control of energy delivery to thermally destroy the target volume. 1(a) a catheter having a distal end and a proximal end; and one or more transducers disposed longitudinally along a central axis of the catheter;', 'the one or more transducers being coupled to a power source external to said catheter;, '(b) an ultrasound applicator disposed at the distal end of said catheter, the ultrasound applicator comprising(c) wherein the ultrasound applicator is configured to be positioned to a treatment location at or near a fibroid tissue mass and deliver high-intensity ultrasound energy sufficient to therapeutically heat said fibroid tissue mass.. An apparatus for treating uterine fibroids, the apparatus comprising: This application is a continuation of U.S. patent application Ser. No. 11/738,391 filed on Apr. 20, 2007, now U.S. Pat. No. ______, incorporated herein by reference in its entirety, which claims the benefit of U.S. provisional patent application Ser. No. 60/885,845 filed on Jan. 19, 2007, incorporated herein by reference in its entirety, U.S. provisional patent application Ser. No. 60/797,421 filed on May 3, 2006, incorporated herein by reference in its entirety, and U.S. provisional patent application Ser. No. 60/793,750 filed on Apr. 20, 2006, incorporated herein by reference in its entirety.Not ApplicableNot ApplicableA portion of the material in this patent document is subject to copyright protection under the copyright laws of the United ...

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Номер записи: 47
21-01-2021 дата публикации

CLOSED LOOP NEUROSTIMULATION OF LARGE-SCALE BRAIN NETWORKS

Номер: US20210016113A1
Автор: Eisaman Matthew Dixon, HUNT Thomas Peter, Laszlo Sarah Ann
Принадлежит:

Closed-loop neurostimulation of large-scale brain networks includes a neurostimulation headset having at least two ultrasound transducer modules configured to generate within a first time period, a first focused ultrasound wave at a region within a portion of a subject's brain, one or more sensors configured to measure, within the first time period, a response from the portion of the subject's brain in response to the first focused ultrasound wave, and an electronic controller in communication with the at least two emitters and the one or more sensors configured to dynamically adjust, based on the measured response from the portion of the subject's brain, a power level of one or more of the at least two ultrasound transducer modules to generate a second focused ultrasound wave at the region within the portion of the subject's brain. 1. A neurostimulation headset , comprising:at least two ultrasound transducer modules configured to generate, within a first time period, a first focused ultrasound wave at a region within a portion of a subject's brain;one or more sensors configured to measure, within the first time period, a response from the portion of the subject's brain in response to the first focused ultrasound wave; andan electronic controller in communication with the at least two emitters and the one or more sensors configured to dynamically adjust, based on the measured response from the portion of the subject's brain, a power level of one or more of the at least two ultrasound transducer modules to generate a second focused ultrasound wave at the region within the portion of the subject's brain.2. The neurostimulation headset of claim 1 , wherein the one or more sensors includes an imaging array that generates imaging ultrasound waves at a first power level claim 1 , the first power level being sufficient to produce an imaging effect of the region within the portion of the subject's brain.3. The neurostimulation headset of claim 1 , wherein the second focused ...

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Номер записи: 48
28-01-2016 дата публикации

Ultrasound apparatuses for thermally-induced renal neuromodulation and associated systems and methods

Номер: US20160023022A1
Автор: Benjamin J. Clark, Denise Zarins, Erik Thai, Howard R. Levin, Mark Gelfand, Nicolas Zadno
Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

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Номер записи: 49
24-01-2019 дата публикации

Patient-specific headset for diagnostic and therapeutic transcranial procedures

Номер: US20190021666A1
Автор: Kullervo Henrik Hynynen
Принадлежит: Sunnybrook Research Institute

Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a pre-selected tissue region.

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Номер записи: 50
24-01-2019 дата публикации

Device And Method for Non-Invasive Neuromodulation

Номер: US20190022425A1
Автор: Karl Deisseroth, M. Bret Schneider
Принадлежит: Leland Stanford Junior University

One embodiment involves modifying neural transmission patterns between neural structures and/or neural regions in a noninvasive manner. In a related exemplary method, sound waves are directed toward a first targeted neural structure and characteristics of the sound waves are controlled at the first target neural structure with respect to characteristics of sound waves at the second target neural structure. In response, neural transmission patterns modified to produce the intended effect (e.g., long-term potentiation and long-term depression of the neural transmission patterns). In a related embodiment, a transducer produces the sound for stimulating the first neural structure and the second neural structure, and an electronically-based control circuit is used to control characteristics of the sound waves as described above to modify the neural transmission patterns between the first and second neural structures.

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Номер записи: 51
22-01-2015 дата публикации

Methods and Devices for Modulating Cellular Activity Using Ultrasound

Номер: US20150025422A1
Автор: TYLER William James P.
Принадлежит:

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused. 179-. (canceled)80. An ultrasound wave generating device for modulating neuronal cellular activity of a neuronal cellular site in a subject , comprisingat least one component for generating an ultrasound wave, adapted to deliver a stimulus waveform to the neuronal cellar site; and{'sup': '2', 'a controller coupled to the at least one component, the controller comprising a process to determine the stimulus waveform delivered to the neuronal cells, wherein the controller is configured with the process to provide the stimulus waveform comprising a plurality of pulses, each pulse of the plurality comprising a plurality of cycles having one or more frequencies in a range from about 0.02 MHz to about 100 MHz at the site of the cells to be modulated, wherein said each pulse of the plurality of pulses comprises a plurality of frequencies and wherein pulses of the plurality are repeated at a pulse repetition frequency ranging from about 0.001 to about 100 kHz to produce spatial-peak temporal-average intensities of no more than 100 W/cm.'}81. A device as in claim 80 , wherein the at least one component for generating ultrasound waves comprises an ultrasonic emitter claim 80 , an ultrasound transducer ...

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Номер записи: 52
28-01-2021 дата публикации

NEUROMODULATION FOR TREATMENT OF RETINAL, CHOROIDAL AND OPTIC NERVE DISORDERS AND/OR DYSREGULATED REDUCED OCULAR BLOOD FLOW (OBF)

Номер: US20210022948A1
Автор: Musallam Ismail Mohammed Yousif
Принадлежит:

Disclosed are devices, systems and methods for non-invasive neuromodulation system for treating inherited or acquired retinal, choroidal and optic nerve disorders caused by acute or chronic dysregulated reduced ocular blood flow (OBF) and/or energy failure by up regulation of trigemino-vascular system (TVS), trigeminal autonomic brain reflexes (TABRs) and pancreatic trigemino-vagal reflex (TVR) through stimulation of ophthalmic nerve (V1), more specifically but not limited to SP, and CGRP containing unmyelinated C nerve fibers. The invention, in some embodiments thereof, relates to the methods for enhancing SP and CGRP expression in neurovascular tissue of the retina and choroid. The invention, in some embodiments thereof, relates to SP/CGRP mediated pathways, including those involved in vasodilatation, augmentation of OBF, RPE proliferation, prevention of apoptosis, suppressing neuroinflammation, promoting migration and differentiation of vascular endothelial cells as well as mobilization of endogenous mesenchymal stem cells (EMSCs) from the bone marrow to the circulation to accelerate tissue repair. The site of stimulation of V1 nerve includes but not limited to; nasal vestibule nasal bridge, forehead, and upper eyelids. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated by sympatholytic agents specifically antioxidants. The subject's TVS and autonomic nervous system (ANS) are modulated in a manner that is effective to treat the subject for retinal, choroidal and/or optic nerve disorders. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli. The invention, in some embodiments thereof, relates to a method for decreasing vascular resistance, enhancing vasodilatation in ophthalmic ...

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Номер записи: 53
02-02-2017 дата публикации

ULTRASONIC PROBE AND ULTRASONIC APPARATUS

Номер: US20170028225A1
Автор: ATSUCHI Robina
Принадлежит:

An ultrasonic probe includes a flexibly longitudinal first sheet portion and a plurality of flexible second sheet portions that are connected to one surface side of the first sheet portion. Each second sheet portion has a connection surface to which the first sheet portion is connected and a drive surface on a side opposite to the connection surface and includes a plurality of ultrasonic substrates respectively including ultrasonic transducers each of which can output an ultrasonic wave from the drive surface. 1. An ultrasonic probe comprising:a flexibly longitudinal first sheet portion; anda plurality of flexible second sheet portions that are connected to one surface side of the first sheet portion,wherein each second sheet portion has a connection surface to which the first sheet portion is connected and a drive surface on a side opposite to the connection surface and includes a plurality of ultrasonic transducers each of which can output an ultrasonic wave from the drive surface.2. The ultrasonic probe according to claim 1 ,wherein the second sheet portions are provided so as to be line-symmetrical with respect to the first sheet portion.3. The ultrasonic probe according to claim 1 ,wherein the second sheet portions are longitudinal in a direction intersecting a longitudinal direction of the first sheet portion.4. The ultrasonic probe according to claim 1 ,wherein each second sheet portion has a longitudinal direction, andwherein each second sheet portion is provided with wiring which is connected to the ultrasonic transducers and is meandering in the longitudinal direction of the second sheet portion5. The ultrasonic probe according to claim 1 ,wherein each second sheet portion has wiring which is connected to the ultrasonic transducers, andwherein the wiring connects the plurality of ultrasonic transducers together in parallel.6. The ultrasonic probe according to claim 1 ,wherein each ultrasonic transducer includes a first ultrasonic transducer which can ...

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Номер записи: 54
02-02-2017 дата публикации

Band transducer ultrasound therapy

Номер: US20170028227A1
Автор: Charles D. Emery, Joshua D. HOPE, Michael T. Peterson
Принадлежит: Ulthera Inc

Embodiments of a dermatological cosmetic treatment and/or imaging system and method can include use of transducer to create a linear thermal treatment zone at a focal depth to form a band shaped treatment area. The system can include one or more ultrasound transducers, a cylindrical transduction element, an imaging element, a hand wand, a removable transducer module, a control module, and/or graphical user interface. In some embodiments, a coated transducer may be used to provide more consistent treatment in cosmetic procedures, including brow lifts, fat reduction, sweat reduction, and treatment of the décolletage. Skin tightening, lifting and amelioration of wrinkles and stretch marks are provided. Treatment may include heating of tissue for a duration to deactivate a percentage of cells in the treatment region.

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Номер записи: 55
31-01-2019 дата публикации

IMPLANTABLE ULTRASOUND GENERATING TREATING DEVICE FOR BRAIN TREATMENT, APPARATUS COMPRISING SUCH DEVICE AND METHOD IMPLEMENTING SUCH DEVICE

Номер: US20190030374A1
Автор: CANNEY Michael, CARPENTIER Alexandre, CHOLVY Matthieu
Принадлежит:

The present invention relates to an apparatus and an implantable ultrasound generating treating device and to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, and comprising several ultrasound generating transducers () which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers () each have one or several operating frequencies. 159-. (canceled)60122020202022abc. Implantable ultrasound generating treating device to induce brain disorder treatment by emission of ultrasound waves , wherein the implantable ultrasound generating treating device is suitable for implantation in or under the skull bone of a patient , wherein the implantable ultrasound generating treating device () comprises an ultrasound emitting grid having several ultrasound generating transducers ( , , , ) held by a common holder () extending along a surface of extension , characterized in that the ultrasound emitting grid is flexible.6122. Implantable device according to claim 60 , characterized in that the holder () comprises a unitary body of flexible material holding the ultrasound generating transducers.62232023ab. Implantable device according to claim 61 , characterized in that the unitary body of flexible material exhibits several holding zones () on each of which are held one or several ultrasound generating transducers () claim 61 , and claim 61 , between the holding zones claim 61 , the unitary body exhibits flexing zones ().63. Implantable device according to claim 62 , characterized in that the flexing zones comprise portions of reduced thickness of the unitary holder.64222525ab. Implantable device according to claim 60 , characterized in that the holder () is non-unitary and comprises several rigid holding portions () claim 60 , on each of which one or several ultrasound generating transducers are held claim 60 , and the rigid holding portions are connected by articulation ...

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Номер записи: 56
31-01-2019 дата публикации

Transcranial ultrasound focusing

Номер: US20190030375A1
Автор: Oron Zachar
Принадлежит: Individual

The invention introduces a system for focusing ultrasonic energy through intervening tissue into a target site within a target tissue region, includes a transducer emitter array, a transducer receiver array, a processor receiving echo signals from the receiver to determine correction factors for the transducer elements to compensate for refraction occurring due to intervening tissue. The correction factors may include phase correction factors, and the phases of excitation signals provided to the transducer elements may be adjusted based upon the phase correction factors to focus the ultrasonic energy to the tissue at the target site.

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Номер записи: 57
30-01-2020 дата публикации

In-medium sculpted tunable graded index lenses

Номер: US20200030638A1
Автор: Matteo Giuseppe Scopelliti, Maysamreza Chamanzar, Yasin Karimi
Принадлежит: CARNEGIE MELLON UNIVERSITY

Disclosed herein is a novel technique that employs non-invasive ultrasound for spatiotemporal modulation of the refractive index in a medium to define and control the trajectory of light within the medium itself, thereby creating a virtual sculpted lens. By varying the amplitude of ultrasonic waves in the medium, the numerical aperture (NA) value of the virtual sculpted lens can be changed. The location of the focus of the virtual sculpted lens can be precisely scanned within a scattering tissue.

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Номер записи: 58
04-02-2021 дата публикации

COOLABLE ULTRASOUND PROBE

Номер: US20210030396A1
Автор: Fish David Andrew, Rijken Antonius Maria
Принадлежит:

An ultrasound probe () is disclosed comprising a probe body () having a mounting area () and a flexible lip () around said mounting area for sealing a space () between the mounting area and a subject () contacted by the ultrasound probe; and a plurality of ultrasound transducer elements () mounted in the mounting area. The probe body further comprises an inlet () to said space and an outlet () from said space for facilitating a fluid flow through said space when sealed. Also disclosed are an ultrasound system () comprising such an ultrasound probe () and a method () of subjecting a subject to ultrasound waves generated with such an ultrasound probe (). 14444. An ultrasound probe) comprising: a probe body having a mounting area and a flexible lip around said mounting area for sealing a space between the mounting area and a part of a subject opposite the mounting area when the subject is contacted by the ultrasound probe to facilitate the creation of a reduced pressure in said space; anda plurality of ultrasound transducer elements mounted in the mounting area;wherein the probe body further comprises an inlet to said space and an outlet from said space for facilitating an air flow through said space when sealed, and wherein, in order to create said reduced pressure upon the outlet being fluidly connected to a fluid displacement apparatus, the inlet is dimensioned to regulate said fluid flow compared to the fluid flow through the outlet or the inlet comprises a fluid flow regulator for regulating said air flow such that an air flow rate through the inlet is smaller than an air flow rate through the outlet at least at ambient pressure in said space.2. The ultrasound probe of claim 1 , wherein the probe body is flexible.3. The ultrasound probe of claim 1 , wherein at least one of the inlet and the outlet are located in the flexible lip.4444. The ultrasound probe of claim 1 , wherein the plurality of ultrasound transducer elements $) are grouped on one or more ultrasound ...

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Номер записи: 59
30-01-2020 дата публикации

Reconfigurable ultrasonically sculpted optical beam paths

Номер: US20200033648A1
Автор: Matteo Giuseppe Scopelliti, Maysamreza Chamanzar, Yasin Karimi
Принадлежит: CARNEGIE MELLON UNIVERSITY

Disclosed herein is a novel reconfigurable spatial and temporal light modulation method that exploits the imaging medium itself by employing a multi-element ultrasonic transducer array as an in-situ acoustic modulator. The medium density can be modulated using different ultrasonic pressure patterns to pattern an incident collimated beam of light.

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Номер записи: 60
08-02-2018 дата публикации

INTERSTITIAL ULTRASONIC DISPOSABLE APPLICATOR AND METHOD FOR TISSUE THERMAL CONFORMAL VOLUME ABLATION AND MONITORING THE SAME

Номер: US20180036558A1
Автор: "NDJIN William Apoutou", CANNEY Michael, CARPENTIER Alexandre, Chapelon Jean-Yves, Chavrier Francoise, DUFAIT Rémi, Lafon Cyril, NGUYEN-DINH An, NOTARD Christophe
Принадлежит:

An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume. 1. An interstitial ultrasound thermal ablation applicator to be inserted into an inhomogeneous tumor lesion for conformal treatment of the tumor lesion , comprising:a body having a longitudinal needle shape and a longitudinal axis; anda plurality of array transducers externally mounted on said body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement;the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesion.2. The interstitial ultrasound thermal ablation applicator according to claim 1 , wherein the plurality of array transducers are for emitting sound waves at a predetermined ultrasonic frequency claim 1 , wherein the sound waves emitted from the plurality of array transducers at the predetermined ultrasonic frequency have a standard wavelength as measured in water as a propagation medium claim 1 , and wherein an elevation dimension of the plurality ...

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Номер записи: 61
06-02-2020 дата публикации

Ultrasonic irradiation device

Номер: US20200037952A1
Автор: Yasuju Takano
Принадлежит: Kyocera Corp

An ultrasonic irradiation device includes: an ultrasonic transducer for external application of focused ultrasound to a body surface; and a tenderness level meter comprising a pressing element that presses the body surface, a pressing unit that presses the pressing element against the body surface, a load measuring unit that measures a pressing force exerted on the body surface by the pressing element, and a pressure recorder for tenderness perception that records a pressing force at which a pressing action of the pressing element causes pain perception. This makes it possible to measure a tenderness level of an ultrasonic irradiation target area without moving an HIFU transducer from above an affected area.

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Номер записи: 62
06-02-2020 дата публикации

MODULAR ULTRASOUND APPARATUS AND METHODS

Номер: US20200037990A1
Автор: Boubriak Olga, Cleveland Robin, Coussios Constantin, Elbes Delphine, Qiao Shan
Принадлежит:

A pressure wave system comprises a plurality of modules (). Each module () comprises a plurality of pressure wave transducer elements, and connection means () operable to connect the modules together in each of a plurality of different configurations. The modules can form a transmitter array having a plurality of different shapes each associated with one of the configurations. 1. A pressure wave system comprising a plurality of modules , each module comprising a plurality of pressure wave transducer elements , and at least one connector operable to connect the modules together in each of a plurality of different configurations whereby the modules can form a transmitter array having a plurality of different shapes each associated with one of the configurations.2. A system according to wherein the transmission elements on each of the modules are arranged in a curved array claim 1 , the curved array of each of the modules being of the same shape as the curved array of each of the other modules.3. A system according to wherein each of the curved arrays has a radius of curvature which is constant along its length and the at least one connector is arranged such that any two of the modules can be connected end-to-end such that the curved arrays of said two of the modules have a common centre of curvature.4. A system according to wherein each of the curved arrays is part-spherical claim 2 , and the at least one connector is arranged such that claim 2 , in each of the configurations claim 2 , the transducer elements of all of the modules together form a single part-spherical array.5. A system according to wherein each of the modules is of a generally rectangular shape having two sides and two ends claim 1 , and the at least one connector is arranged such that two of the modules can be connected together side-to-side or end-to-end.6. A system according to wherein:each of the transducer elements is operable to transmit pressure waves and the system further comprises a ...

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Номер записи: 63
07-02-2019 дата публикации

MULTIWAVELENGTH ULTRASONIC TISSUE TREATMENT APPARATUS

Номер: US20190038921A1
Автор: Domankevitz Yacov
Принадлежит:

An apparatus for the treatment of skin tissue includes at least one ultrasound transducer for placement on the skin tissue surface; at least two drivers for driving the at least one transducer; a controller which is configured to control the at least two drivers; the controller is configured to drive the at least two drivers at different frequencies to affect different depths in the skin tissue. 117.-. (canceled)18. Apparatus for the treatment of skin tissue comprising:two ultrasound transducers for placement on the skin tissue surface;one or more drivers for driving the two transducers;a controller configured to control the one or more drivers;wherein the two transducers are angled with respect to the tissue surface towards one another such that, when activated by the programmable controller, ultrasound energy delivered to the skin tissue by the two transducers is superimposed.19180. The apparatus of claim 18 , wherein one of the two transducers delivers ultrasound energy at an angle X relative to the skin tissue claim 18 , and the other of the two transducers delivers ultrasound energy at an angle -X relative to the skin tissue claim 18 , whereby energy distributions from the two ultrasound transducers are superimposed to provide homogenous energy distribution.20. The apparatus of claim 18 , wherein the controller is configured to drive the one or more drivers one of sequentially or simultaneously.21. The apparatus of claim 18 , wherein the two transducers are activated by the programmable controller to operate at one of the same or different frequencies.22. The apparatus of claim 18 , wherein the activation of the two transducers causes one or more of skin tightening and fat heating.23. The apparatus of claim 18 , further comprising a polygonal-shaped hollow housing and wherein the two transducers are mounted within the housing and arranged to face each other.24. The apparatus of claim 23 , further comprising a device for causing suction within the cavity claim ...

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Номер записи: 64
07-02-2019 дата публикации

EXTERNAL ULTRASOUND GENERATING TREATING DEVICE FOR SPINAL CORD AND/OR SPINAL NERVE TREATMENT, APPARATUS COMPRISING SUCH DEVICE AND METHOD

Номер: US20190038922A1
Автор: CARPENTIER Alexandre
Принадлежит:

An external ultrasound generating treating device () to induce spinal cord and/or spinal nerve treatment comprises at least two sub-arrays of ultrasound generating treatment transducers, a left sub-array (L) being located on a left lateral side and a right sub-array (R) being located on a right lateral side of the central longitudinal axis (Ai). The device comprises a support structure () having at least one module () comprising a left lateral section (L) and a right lateral section (R). The support structure () maintains, in use of the device, a constant distance and a constant relative angular orientation around the central longitudinal axis (Ai) between the first left and first right treatment transducers or set of treatment transducers (L, R). Also disclosed is an apparatus including the external ultrasound generating treating device () and methods of its use. 23634342020iiiii- External device according to claim 1 , characterized in that the support structure comprises an adjusting mechanism () for adjusting claim 1 , around a longitudinal axis (Ai) claim 1 , a relative angular orientation between the left and right lateral sections (L claim 1 , R) of the support structure claim 1 , so as to adjust the relative angular orientation around the longitudinal axis between the first left and first right treatment transducers or set of treatment transducers (L claim 1 , R).336i- External device according to claim 2 , characterized in that the adjusting mechanism () comprises an articulation.43634342020iiiii- External device according to claim 1 , characterized in that the support structure comprises an adjusting mechanism () for adjusting a distance between the left and right lateral sections of the support structure (L claim 1 , R) claim 1 , so as to adjust the distance between the first left and first right treatment transducers or set of treatment transducers (L claim 1 , R).54012020ii- External device according to claim 4 , characterized in that the adjusting ...

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Номер записи: 65
15-02-2018 дата публикации

SYSTEM AND METHOD FOR ENERGY DELIVERY TO TISSUE WHILE MONITORING POSITION, LESION DEPTH, AND WALL MOTION

Номер: US20180043189A1
Автор: Arenson James W., Gallup David A., Thapliyal Hira V.
Принадлежит:

Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue. 1. A system for ablating tissue , said system comprising:an elongate device comprising an ultrasound transducer adjacent a distal portion thereof and configured to move over a surface of the target tissue;a sensor coupled to the distal portion of the elongate device, wherein the sensor is configured to detect one or more tissue parameter of the target tissue; and calculate a motion of the target tissue relative to the ultrasound transducer based on the one or more tissue parameter;', 'measure a distance between the ultrasound transducer and the surface of the target tissue based on the one or more tissue parameter;', 'generate a map of the surface of the target tissue based on the measured distance;', 'identify an ablation path on the tissue based on the generated map;', 'control the ultrasound transducer to deliver an ablation energy to the ablation path to ablate the target tissue; and', 'adjust the ablation based on the calculated motion and the measured distance to form a continuous lesion in the target tissue., 'a processor operatively coupled to the elongate device, the ultrasound transducer, and the sensor, wherein the processor comprises instructions to2. The system of claim 1 , wherein the continuous lesion is configured to block aberrant electrical pathways in the ...

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Номер записи: 66
03-03-2022 дата публикации

ULTRASONIC SYSTEM FOR SKIN-TIGHTENING OR BODY-SHAPING TREATMENT

Номер: US20220062660A1
Автор: Eshel Yoram, VERNER RASHKOVSKY Ines
Принадлежит:

A system for providing an ultrasonic skin-tightening treatment is disclosed. The system comprises a) a flexible sleeve wrapped around a treatment volume of a patient; b) one or more treatment panels, arranged on an inside wall of the sleeve, provide ultrasound energy and cooling to the treatment volume; and c) a control module controls ultrasonic and cooling parameters independently for each treatment panel. The system enables hands-free treatment over an entire treatment volume, with localized variations of the parameters, according to treatment requirements, under each treatment panel. The ultrasound and cooling parameters may be varied to select treatment of a particular depth below the skin surface. 1. A system for providing an ultrasonic skin-tightening or body-shaping treatment , comprisinga. a sleeve configured for fixedly wrapping around an organ of a mammalian body; said organ comprising a treated volume of a layer of tissue(s) underneath an area of skin surface of said organ; i. an ultrasonic element, configured to provide ultrasound waves to a portion of said treated volume underneath said treatment panel;', 'ii. a cooling plate, configured to remove heat from said treated volume portion; and, 'b. an arrangement of one or more treatment panels disposed on an inside surface of said sleeve, each said treatment panel comprising'}c. a control module, in electrical connection with said treatment panels, configured to receive temperature outputs of said temperature sensors and to control said ultrasonic elements—including intensity, frequency, and/or duty cycle of said ultrasound waves—and to control said cooling plate temperature;wherein said control module is further configured to control said ultrasonic elements and said cooling plates of each said treatment panel independently, thereby enabling hands-free treatment, with localized variations in said controls as needed, throughout said treatment volume.2. The system of claim 1 , wherein one or more of said ...

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Номер записи: 67
03-03-2022 дата публикации

DEVICES AND METHODS FOR MODULATING BRAIN ACTIVITY

Номер: US20220062661A1
Автор: Tyler William James
Принадлежит:

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions. 1. (canceled)2. A device , the device comprising:a structure configured to fit onto a subject's head;an array of either or both magnetic transducers or functional near-infrared spectroscopy (fNIRS) sensors;a plurality of phased array ultrasonic transducers coupled to the structure and configured to emit ultrasound energy, wherein each phased array ultrasonic transducer comprises a plurality of concentrically arranged piezoelectric active regions; anda controller configured to sense brain activity from the array of magnetic transducers or functional near-infrared spectroscopy (fNIRS) sensors and to coordinate application of ultrasound to one or more brain regions using the plurality of phased array ultrasonic transducers.3. The device of claim 2 , wherein the controller comprises a local microprocessor configured to modulate one or more of an ultrasound waveform and a frequency claim 2 , intensity or waveform characteristic to adjust the ultrasound being delivered based on sensed brain activity.4. The device of claim 2 , further comprising a magnetoencephalography (MEG) or an electroencephalography (EEG) sensor adapted to detect specific thalamocortical oscillations.5. The device of claim 2 , further comprising controls configured to allow a user to control the device.6. The device of claim 2 , wherein the phased array ultrasonic transducers are configured to provide a predominantly non-thermal mechanism of action.7. The device of claim 2 , wherein the phased ...

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Номер записи: 68
10-03-2022 дата публикации

ULTRASOUND-INDUCED CONVECTION FOR DRUG DELIVERY AND TO DRIVE GLYMPHATIC OR LYMPHATIC FLOWS

Номер: US20220072128A1
Автор: Airan Raag D.
Принадлежит:

The utility of intrathecal delivery is limited by the poor brain and spinal cord parenchymal uptake of intrathecally delivered agents. A simple noninvasive transcranial ultrasound protocol is provided that significantly increases the brain parenchymal uptake of intrathecally administered drugs and antibodies. This protocol of transcranial ultrasound can accelerate glymphatic fluid transport from the cisternal space into the parenchymal compartment. The low intensity and noninvasive approach of ultrasound in this protocol underscores the ready path to clinical translation of this technique. This low-intensity transcranial ultrasound protocol can be used to directly bypass the blood-brain barrier for whole-brain delivery of a variety of agents. Additionally, this protocol is useful as a means to probe the causal role of the glymphatic system in the variety of disease and physiologic processes to which it has been correlated. 1. A method of increasing brain penetration of an intrathecally administered agent , the method comprising:intrathecally administering an agent to a subject; andapplying transcranial ultrasound to the subject to modulate the glymphatic pathway to promote brain penetration of the intrathecally administered agent.2. The method of claim 1 , wherein the method comprises applying transcranial ultrasound across the whole brain of the subject.3. The method of claim 1 , wherein the transcranial ultrasound has a frequency ranging from 600 kHz to 700 kHz.4. The method of claim 1 , wherein the transcranial ultrasound has an intensity ranging from 10 mW/cmto 450 mW/cm.5. The method of claim 1 , wherein the transcranial ultrasound has a mechanical index ranging from 0.2 to 0.3.6. The method of claim 1 , wherein the transcranial ultrasound comprises transcranial focused ultrasound.7. The method of claim 1 , wherein the method comprises upregulating the glymphatic pathway.8. The method of claim 1 , wherein the agent has a molecular weight ranging from 1 kDa to ...

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Номер записи: 69
10-03-2022 дата публикации

Medical device with cmut array and solid state cooling, and associated methods and systems

Номер: US20220072338A1
Автор: Andre Khoury, Arif Sanli Ergun, Butrus T. Khuri-Yakub, John N. Irwin, III
Принадлежит: Ultra Hom LLC

A medical device includes a capacitive micromachined ultrasonic transducer (CMUT) array configured to emit ultrasound to target tissue, and at least one thermoelectric cooler mechanically coupled with the CMUT array and configured to cool non-target tissue heated by the ultrasound. The medical device may be implemented in a catheter together with a solid thermal conductor coupled to the thermoelectric cooler and extending along the catheter, to conduct heat away from the thermoelectric cooler. A catheter or catheter sleeve includes a tubular wall for insertion into a body channel, and at least one thermoelectric cooler coupled to the tubular wall for cooling the body channel wall. A catheter sleeve includes tubular casing for insertion into a body channel and capable of encasing a catheter, and at least one sensor coupled to the tubular casing for sensing one or more properties of the body channel wall, such as temperature and pressure.

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Номер записи: 70
28-02-2019 дата публикации

PIEZOELECTRIC SYSTEM FOR ULTRASONIC THERMOTHERAPY AND ELECTROTHERAPY

Номер: US20190060676A1
Автор: LIN Sheuan-Perng, TING Yung, YU CHIH-HSUAN
Принадлежит:

A piezoelectric system for ultrasonic thermotherapy and electrotherapy comprises a first piezoelectric element, a proof mass, a second piezoelectric element and an output unit. The proof mass is disposed between the first piezoelectric element and the second piezoelectric element. The first piezoelectric element is powered by a power source to generate oscillation, which is transferred by the proof mass to the second piezoelectric element so as to cause the second piezoelectric element to move and generate power. The output unit comprises a connecting surface and a tip surface. The output unit is electronically connected with the second piezoelectric element, wherein the connecting surface is connected with the first piezoelectric element and the tip surface is formed in a tapered shape. The oscillation from the first piezoelectric element and the power generated by the second piezoelectric element are output through the tip surface. 1. A piezoelectric system for ultrasonic thermotherapy and electrotherapy , comprising:a first piezoelectric element powered by a power source to generate an oscillation;a second piezoelectric element;a proof mass disposed between the first piezoelectric element and the second piezoelectric element, the proof mass being provided for transferring the oscillation to the second piezoelectric element so as to cause the second piezoelectric element to generate power; andan output unit comprising a connecting surface and a tip surface, the first piezoelectric element being disposed between the output unit and the proof mass, the output unit being electrically connected with the second piezoelectric element, wherein the connecting surface is connected with the first piezoelectric element and the tip surface is formed in a tapered shape such that the oscillation from the first piezoelectric element and the power generated by the second piezoelectric element are output through the tip surface.2. The piezoelectric system for ultrasonic ...

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Номер записи: 71
08-03-2018 дата публикации

Implantable thermal treatment method and apparatus

Номер: US20180064484A1
Автор: Chris J. Diederich, David S. Bradford, Jeffrey C. Lotz, William H. Nau
Принадлежит: UNIVERSITY OF CALIFORNIA

A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

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Номер записи: 72
08-03-2018 дата публикации

ULTRASOUND DEVICE FOR PRECISE TISSUE SEALING AND BLADE-LESS CUTTING

Номер: US20180064964A1
Автор: Kharin Nikolay
Принадлежит:

An electrosurgical instrument for sealing and cutting tissue is provided. The instrument includes a housing having a plurality of transducers included therein and a waveguide coupled to and extending from the housing. An end effector assembly disposed at a distal end of the waveguide includes a pair of opposing jaw members, where at least one of the jaw members includes a transducer. The transducer is configured to receive an acoustic signal from the plurality of transducers in the housing. 116-. (canceled)17. An end effector assembly , comprising:a first jaw member including a probe configured to both receive an acoustic signal and output an electrical signal in response to receiving the acoustic signal.18. The end effector assembly according to claim 17 , wherein the probe is configured to transmit the electrical signal to a generator.19. The end effector assembly according to claim 17 , wherein the probe is a piezoceramic transducer.20. The end effector assembly according to claim 17 , wherein the probe is disposed beneath a sealing surface of the first jaw member.21. The end effector assembly according to claim 17 , wherein the probe is integrally formed with a sealing surface of the first jaw member.22. The end effector assembly according to claim 17 , wherein the probe is formed as a stop member disposed on a sealing surface of the first jaw member.23. The end effector assembly according to claim 17 , further comprising a second jaw member disposed in opposing registration to the first jaw member.24. The end effector assembly according to claim 23 , wherein at least one of the first jaw member or the second jaw member is moveable between a first spaced-apart position and a second approximated position relative to the other one of the first and second jaw members.25. An electrosurgical instrument claim 23 , comprising:a housing;a plurality of transducers disposed within the housing;a waveguide extending distally from the housing; andan end effector assembly ...

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Номер записи: 73
11-03-2021 дата публикации

SYSTEM FOR INDUCING SONOPORATION OF A DRUG INTO CANCER CELLS AND METHOD THEREOF

Номер: US20210069332A1
Автор: FALETTO Daniele, GIUSTETTO Pierangela
Принадлежит: Freedom Waves S.R.L

System for inducing sonoporation of a drug into cancer cells in a tumor and method thereof, the system comprising a generator configured to provide electrical energy at an ultrasound frequency; an ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity pulsed ultrasonic waves defined by operation parameters, said operation parameters comprising the frequency, the duty cycle, the operation time of the ultrasonic waves; an input device enabling an operator to enter configuration data comprising: type of tumor, type of drug, localization of secondary tumor, anthropometric measurements and grade of tumor, and a processor configured to determine the values of the operation parameters on the basis of the entered configuration data and control the generator and the ultrasound probe to operate according to said determined values, wherein the value of the frequency is determined on the basis of the type of tumor, the localization of the tumor, the grade of tumor and the anthropometric measurements, the value of the duty cycle is determined on the basis of the drug, the type of tumor and the grade of the tumor, and the value of said operation time being determined on the basis of at least the type of tumor and the type of drug. 1. A system for inducing sonoporation of a drug into cancer cells in a tumor , comprising:a generator configured to provide electrical energy at an ultrasound frequency;at least one ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity non-focalized pulsed ultrasonic waves defined by operation parameters, said operation parameters comprising the frequency and the duty cycle of the ultrasonic waves: an input device enabling an operator to enter configuration data comprising: type of tumor and type of drug; and', determine the values of said operation parameters on the basis of the entered configuration data, wherein ...

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Номер записи: 74
07-03-2019 дата публикации

ULTRASOUND SYSTEM FOR CEREBRAL BLOOD FLOW IMAGING AND MICROBUBBLE-ENHANCED BLOOD CLOT LYSIS

Номер: US20190069875A1
Автор: Brechbiel Tracy C., Powers Jeffry Earl, Seip Ralf, Shi William Tao
Принадлежит:

An ultrasonic diagnostic imaging system is described which can diagnose, treat, or monitor the cranial vasculature for obstructions such as blood clots causing ischemic stroke. The system has a headset which maintains two transducer arrays in contact with acoustic windows through the temporal bones on opposite sides of the head. The clinician is aided in properly positioning the arrays over the best acoustic windows through the bone by a signal produced by one of the arrays in response to transmission through the cranium by the other array, which passes through the temporal bones on both sides of the head. The amplitude of this through- transmission signal is detected and displayed to the clinician, either qualitatively or quantitatively, as the arrays are positioned. 1. An ultrasound system for cranial diagnosis , monitoring and/or therapy comprising:a first and a second array of transducer elements;a transducer array headset configured to maintain the first and second arrays in contact with first and second acoustic windows on a first and second side of a patient's head, respectively;a detector that is coupled to a transducer element of the second array and configured to produce a signal in response to the reception of ultrasound by the transducer element of the second array in response to reception of a transmission of ultrasound by the first array;a graphics processor coupled to the detector, the graphics processor configured to produce a graphical indicator of signal amplitude, based at least in part on an amplitude of the tansmission of ultrasoung by the first array received by the second array; anda display that is coupled to the graphics processor and configured to display the graphical indicator.2. The ultrasound system of claim 1 , wherein the first and second arrays further comprise two dimensional arrays of transducer elements; andwherein the transducer element of the second array to which the detector is coupled further comprises a central transducer ...

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Номер записи: 75
16-03-2017 дата публикации

Pulse amplifier for driving ultrasound transducers

Номер: US20170072225A1
Автор: Adam D. MAXWELL, Bryan Cunitz, Michael R. Bailey, Timothy L. Hall, Vera KHOKHLOVA
Принадлежит: University of Michigan, UNIVERSITY OF WASHINGTON

Embodiments of the invention include improved radiofrequency (RF) pulse amplifier systems that incorporate an energy array comprising multiple capacitors connected in parallel. The energy array extends the maximum length of pulses and the maximum achievable peak power output of the amplifier when compared to similar systems. Embodiments also include systems comprising the amplifier configured to drive a load, wherein the load may include one or more ultrasound (e.g., piezoelectric) transducers Related methods of using the amplifier are also provided.

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Номер записи: 76
05-03-2020 дата публикации

Minimally-invasive surgical instrument including three-dimensional (3d) ultrasound imaging and focused ultrasound treatment capabilities

Номер: US20200069323A1
Автор: Matthew S. Cowley
Принадлежит: COVIDIEN LP

A surgical system includes a surgical instrument having a shaft and an end effector extending distally from the shaft. The end effector includes a plurality of ultrasound sensors supported about a support ring. The ultrasonic sensors are rotatable between an imaging orientation, wherein, the ultrasound sensors are directed in generally parallel orientations relative to one another for imaging tissue in an imaging mode, and at least one treatment orientation, wherein the ultrasound sensors are directed towards a common focus point for treating tissue in a treatment mode.

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Номер записи: 77
18-03-2021 дата публикации

BIOLOGICAL OBJECT IMAGE-CAPTURING AND TREATMENT SYSTEM AND METHOD

Номер: US20210077833A1
Автор: Liou Jian-Chiun
Принадлежит:

A biological object image-capturing and treatment system includes a micro detection and treatment device. The micro detection and treatment device includes a plurality of signal transmitting and receiving elements arranged as an array, wherein adjacent at least two signal transmitting and receiving elements transmit signals or receive signals during different periods. When performing an image-capturing procedure, at least one signal transmitting and receiving element transmits a first power signal and, when performing a treatment procedure, at least one signal transmitting and receiving element transmits a second power signal, wherein a power of the first power signal is different from a power of the second power signal. 1. A biological object image-capturing and treatment system for performing an image-capturing procedure and a treatment procedure , comprising:a micro detection and treatment device including a signal transmitting and receiving element array having a plurality of signal transmitting and receiving elements, wherein the signal transmitting and receiving elements are set in a manner that adjacent at least two signal transmitting and receiving elements transmit signals or receive signals during different periods,wherein, when performing the image-capturing procedure, at least one signal transmitting and receiving element transmits a first power signal and, when performing the treatment procedure, at least one signal transmitting and receiving element transmits a second power signal, where the first power signal has a power different from that of the second power signal.2. The biological object image-capturing and treatment system of claim 1 , wherein claim 1 , when the image-capturing procedure is performed claim 1 , a single signal transmitting and receiving element or a plurality of signal transmitting and receiving elements transmits the first power signal to different positions of a target object claim 1 , and a single signal transmitting and ...

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Номер записи: 78
18-03-2021 дата публикации

MULTI-FREQUENCY ULTRASOUND TRANSDUCERS

Номер: US20210077834A1
Автор: Vitek Shuki, Vortman Kobi
Принадлежит:

Treatment of target tissue in a target volume having multiple target regions includes causing an ultrasound transducer to transmit a first series of ultrasound waves having a first frequency to a first one of target regions; and causing the ultrasound transducer to transmit a second series of ultrasound waves having a second frequency, different from the first frequency, to a second one of the target regions, different from the first one of the target regions, based on one or more different anatomical characteristics (such as focal lengths) between the first and second ones of the target regions. 1. A system for treating target tissue in a target volume comprising a plurality of target regions , the system comprising:an ultrasound transducer for transmitting ultrasound waves having two or more frequencies; and (a) cause the ultrasound transducer to transmit a first series of ultrasound waves having a first frequency to a first one of target regions; and', '(b) cause the ultrasound transducer to transmit a second series of ultrasound waves having a second frequency, different from the first frequency, to a second one of the target regions, different from the first one of the target regions, based on at least one different anatomical characteristic between the first and second ones of the target regions., 'a controller configured to2. The system of claim 1 , wherein the first frequency is higher than the second frequency and the at least one anatomical characteristic is relative location claim 1 , a location of the first target region corresponding to a shorter focal depth of the transducer than that of the second target region.3. The system of claim 1 , wherein the first frequency is higher than the second frequency and the at least one anatomical characteristic is vascularization claim 1 , the first target region having higher vascularity than the second target region.4. The system of claim 1 , further comprising a monitoring system for measuring the at least one ...

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Номер записи: 79
19-03-2015 дата публикации

INTERCONNECTABLE ULTRASOUND TRANSDUCER PROBES AND RELATED METHODS AND APPARATUS

Номер: US20150080724A1
Автор: Charvat Gregory L., Corteville Gregory, Fife Keith G., Ralston Tyler S., Rothberg Jonathan M., Sanchez Nevada J.
Принадлежит: Butterfly Network, Inc.

Ultrasound devices and methods are described, including a repeatable ultrasound transducer probe having ultrasonic transducers and corresponding circuitry. The repeatable ultrasound transducer probe may be used individually or coupled with other instances of the repeatable ultrasound transducer probe to create a desired ultrasound device. The ultrasound devices may optionally be connected to various types of external devices to provide additional processing and image rendering functionality. 1. An apparatus , comprising:a semiconductor substrate having a width and height, the width being at least twice as large as the height, the substrate having a top metal layer having a thickness between approximately 0.5 microns and approximately 10 microns;a plurality of complementary metal oxide semiconductor (CMOS) ultrasonic transducers integrated with the substrate, wherein at least one CMOS ultrasonic transducer of the plurality of CMOS ultrasonic transducers is disposed above the top metal layer; andCMOS control circuitry on the substrate, coupled to the plurality of CMOS ultrasonic transducers and configured to control the plurality of CMOS ultrasonic transducers to support one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) ultrasound imaging,wherein the CMOS control circuitry comprises a waveform generator coupled to the at least one CMOS ultrasonic transducer of the plurality of CMOS ultrasonic transducers, the waveform generator being configurable to generate any of an impulse, a continuous wave, a coded excitation, or a chirp waveform.2. The apparatus of claim 1 , wherein the plurality of CMOS ultrasonic transducers and the CMOS control circuitry represent multiple instances of an ultrasound probe tiled on the semiconductor substrate.3. The apparatus of claim 1 , wherein the CMOS control circuitry is configured to control at least some of the plurality of CMOS ultrasonic transducers to provide high intensity focused ultrasound (HIFU).4. The ...

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Номер записи: 80
23-03-2017 дата публикации

Focused ultrasound split-foci control using spherical-confocal-split array with dual frequency of fundamental and harmonic superimposition

Номер: US20170080259A1
Автор: Dong Tengju, Guan Yubo, Lu Mingzhu, WAN Mingxi, Wang Rui, Zhang Linglu
Принадлежит:

A spherical-confocal-split array with dual frequency of fundamental and harmonic superimposition includes: array elements which are spherically confocal, whose quantity is an even number, wherein a half of the array elements operate with a lower frequency, and the other half of the array elements operate with a higher frequency; both the lower frequency and the higher frequency are MHz high-frequencies; each of the array elements corresponds to a frequency drive; array element beams don't superimpose outside the focal region; each of the array elements is connected to a channel amplifier () through corresponding impedance matching (); and a multi-channel waveform controller () is connected to the channel amplifier () for controlling amplitudes and phases of all channels. The dual-frequency spherical sectorial split array is able to generate split multi-foci of the focal plane with the dual frequencies; and control strong interference of transient cavitation clouds at the adjacent foci. 1. A spherical-confocal-split array with the dual frequency of fundamental and the harmonic superimposition , comprising: array elements which are spherically confocal , whose quantity is an even number , wherein a half of the array elements operate with a lower frequency , and the other half of the array elements operate with a higher frequency; both the lower frequency and the higher frequency are MHz high-frequencies; each of the array elements corresponds to a frequency drive; each of array element beams only superimposes inside a focal region instead of outside the focal region; each of the array elements is connected to a channel amplifier through corresponding impedance matching; and a multi-channel waveform controller is connected to the channel amplifier for controlling amplitudes and phases of all channels.2. The spherical-confocal-split array with the dual frequency of fundamental and the harmonic superimposition claim 1 , as recited in claim 1 , wherein a range of the MHz ...

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Номер записи: 81
31-03-2022 дата публикации

Apparatus and Method for Directing Energy from a Multi-Element Source

Номер: US20220096872A1
Автор: Aaro Tuominen
Принадлежит: PROFOUND MEDICAL INC

An apparatus for controlling the angular direction of energy emitted from a plurality of energy delivery devices. The apparatus includes a plurality of rods, each rod mechanically coupled to one of the energy delivery devices, to a stationary plate, and to a moveable plate. The stationary plate includes holes that are configured to receive a portion of a first rotatable joint that is mechanically coupled to each rod. The moveable plate includes holes that are configured to receive a portion of a second rotatable joint, the second rotatable joint slidingly engaging a portion of the respective rod. The angle of each rod changes when the moveable plate is moved in any direction with respect to the stationary plate. Changing the rod angle changes the angular direction of the energy emitted from the energy delivery devices such that the energy passes through an intended focal position.

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Номер записи: 82
26-03-2015 дата публикации

Method and system for treating stretch marks

Номер: US20150088040A1
Автор: Inder Raj S. Makin, Michael H. Slayton, Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

Methods and systems for treating stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis and a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth from 0 mm to 1 cm with a conformal selective deposition of ultrasound energy without damaging an intervening tissue in the range of frequencies from 2 to 50 MHz. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.

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Номер записи: 83
12-06-2014 дата публикации

Ultrasound therapy transducer head with temperatire control structure

Номер: US20140163433A1
Автор: Junho Song, Kullervo H. Hynynen
Принадлежит: Sunnybrook Health Sciences Centre

An ultrasound therapy transducer head comprises an ultrasound source emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements, integrated driving electronics coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics.

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Номер записи: 84
29-03-2018 дата публикации

ULTRASOUND PROBE FOR TREATMENT OF SKIN

Номер: US20180085609A1
Автор: Barthe Peter G., Makin Inder Raj S., Slayton Michael H.
Принадлежит:

Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof. 1. (canceled)2. An ultrasound treatment probe for treating skin tissue , the probe comprising: wherein the piezoelectric ultrasound therapy element is configured to provide a single mechanical focus,', 'wherein the single mechanical focus is configured to provide ultrasound therapy energy in a form of a single thermal focus in a tissue below a skin surface,', 'wherein the single thermal focus is formed without electronic focusing and without a lens,, 'a single, focused piezoelectric ultrasound therapy element,'}wherein the housing is configured for acoustic coupling to the skin surface,wherein the piezoelectric ultrasound therapy element is configured for delivery of the ultrasound therapy energy to heat the tissue below the skin surface to a temperature of greater than 60 degrees Celsius,wherein the tissue comprises at least a portion of at least one of the group consisting of: a dermis and a fascia,wherein the piezoelectric ultrasound therapy element is configured for delivery of the ultrasound therapy energy at the temperature sufficient to denature at least a portion of the tissue in a region of interest,wherein the piezoelectric ultrasound therapy element delivers the ...

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Номер записи: 85
30-03-2017 дата публикации

CATHETER BALLOON METHODS AND APPARATUS EMPLOYING SENSING ELEMENTS

Номер: US20170086747A1
Автор: "DAngelo Robert", De Graff Bassel, DOWLING Kevin, Ghaffari Roozbeh, Hsu Yung-Yu, Klinker Lauren E., Lee Stephen P., Liu Cliff
Принадлежит:

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state. 138-. (canceled)39. A stretchable electronic system comprising:a flexible annular interconnect; anda first plurality of electrodes coupled to the flexible annular interconnect.40. The stretchable electronic system of claim 39 , wherein the flexible annular interconnect has a first radius and wherein each electrode in the first plurality of electrodes is coupled to the flexible annular interconnect via at least one flexible connector extending from the annular interconnect such that the first plurality of electrodes are positioned at a second radius distinct from the first radius.41. The stretchable electronic system of claim 39 , wherein the flexible annular interconnect is formed from a conductive material.42. The stretchable electronic system of claim 40 , wherein the second radius is greater than the first radius.43. The stretchable electronic system of claim 40 , further comprising a second plurality of electrodes coupled to the flexible annular interconnect claim 40 , each electrode in the second plurality of electrodes coupled to the flexible annular interconnect via the at least one flexible connector extending from the annular interconnect such that the second plurality of electrodes are positioned at a third radius claim 40 , distinct from the first and second radii.44. The stretchable electronic system of claim 43 , wherein the third radius is greater than the second radius.45. The stretchable electronic system of claim 39 , further comprising a flexible substrate forming an inflatable body claim 39 , the flexible annular interconnect and the first plurality of ...

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Номер записи: 86
30-03-2017 дата публикации

CATHETER BALLOON METHODS AND APPARATUS EMPLOYING SENSING ELEMENTS

Номер: US20170086748A1
Автор: "DAngelo Robert", De Graff Bassel, DOWLING Kevin, Ghaffari Roozbeh, Hsu Yung-Yu, Klinker Lauren E., Lee Stephen P., Liu Cliff
Принадлежит:

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state. 156-. (canceled)57. A system for mapping contact with a surface , the system comprising:an inflatable body;a plurality of electrodes coupled to the inflatable body;an electronic display electrically coupled to the plurality of electrodes, the electronic display providing a visual representation of the spatial location of the plurality of electrodes on the inflatable body, the electronic display changing a visual attribute of an electrode in the plurality of electrodes in response to a change in an electrical signal produced by the electrode, and the change in the electrical signal identifying a contact condition of the electrode with respect to the surface.58. The system of claim 57 , wherein the visual attribute is a binary representation59. The system of claim 57 , wherein the visual attribute is a quantitative representation.60. (canceled)61. (canceled) This application claims priority to U.S. provisional application Ser. No. 61/515,713, filed Aug. 5, 2011, entitled “Catheter Balloon Methods and Apparatus Employing Lumen Contact Sensors,” which is hereby incorporated herein by reference in its entireties.High quality medical sensing and imaging data has become increasingly beneficial in the diagnoses and treatment of a variety of medical conditions. The conditions can be associated with the digestive system, the cardio-circulatory system, and can include injuries to the nervous system, cancer, and the like.For example, complex fractionated electrogram (CFAE) triggers within the right and left atria play a role in the pathogenesis of persistent and permanent atrial ...

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Номер записи: 87
05-05-2022 дата публикации

MRI-COMPATIBLE IMPLANTABLE WIRELESS DIAGNOSTIC AND THERAPEUTIC ULTRASOUND

Номер: US20220133263A1
Автор: Armand Mehran, BELZBERG Micah, BEN-SHALOM Netanel, GORDON Chad R., MANBACHI Amir
Принадлежит:

An implantable ultrasonic transducer device for capturing radiographic and biometric data is provided. The implantable ultrasonic transducer device includes a transducer array configured to provide ultrasonic waves to a target area and to obtain reflected ultrasonic waves from the target area; a controller electrically coupled to the transducer array and configured to provide one or more control signals to the transducer array to control one or more modes of operation of the transducer array; and an antenna electrically coupled to the controller and configured to wireless transmit and receive data from an external device, wherein the transducer array, the controller, and the antenna are completely contained within a body cavity of a patient and an activation surface of the transducer array is positioned in physical contact with a portion of a treatment area of the patient with no air gap between the activation surface and the treatment area.

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Номер записи: 88
19-03-2020 дата публикации

HIGH-INTENSITY FOCUSED ULTRASOUND DEVICE AND METHOD FOR CONTROLLING PIEZOELECTRIC DRIVING DEVICE USED IN THE SAME

Номер: US20200086145A1
Автор: Hong Suk Ki, YOO Seon Uk
Принадлежит: ILOODA Co., Ltd.

A high-intensity focused ultrasound (HIFU) device and a method for controlling the piezoelectric driving device achieve accurate and stable control as to movement of a transducer and a treatment position by use of a piezoelectric driving device configured to have a compact size in accordance with a great reduction in the size of a handpiece. 1. A method for controlling a piezoelectric driving device to linearly move a transducer disposed in a cartridge of a high-intensity focused ultrasound handpiece , comprising:transmitting a high frequency signal to a piezoelectric motor, thereby causing the piezoelectric motor to generate piezoelectric ultrasound, and causing a piezoelectric driving shaft connected to the piezoelectric motor to generate vibration in accordance with the piezoelectric ultrasound;coupling a piezoelectric operating unit provided with the transducer to the piezoelectric driving shaft, thereby causing the piezoelectric operating unit to move along the piezoelectric driving shaft in accordance with the vibration of the piezoelectric driving shaft; andpredetermining information as to positions, at which the transducer radiates ultrasound, and performing a control operation for stopping the movement of the piezoelectric operating unit along the piezoelectric driving shaft when it is sensed that the piezoelectric operating unit reaches one of the predetermined position, and irradiating ultrasound through the transducer.2. The method according to claim 1 , wherein the control operation for stopping the piezoelectric operating unit and irradiating ultrasound through the transducer comprises:previously storing, in association with a position sensor to sense a position of the piezoelectric operating unit, sensing values respectively corresponding to a plurality of positions, at which the transducer radiates ultrasound, stopping an operation of the piezoelectric motor to stop the piezoelectric operating unit and controlling the transducer to radiate ultrasound ...

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Номер записи: 89
01-04-2021 дата публикации

METHOD AND SYSTEM FOR SUPPORTING SKIN TREATMENT USING ULTRASONIC WAVES, AND NON-TEMPORARY COMPUTER-READABLE RECORDING MEDIUM

Номер: US20210093895A1
Автор: KIM Tae Kyun, Shin Seung Woo
Принадлежит:

According to an embodiment of the present disclosure, a system for supporting a skin treatment using ultrasound comprises a treatment map management unit configured to determine an ultrasonic treatment map of at least one of a treatment intensity, a treatment number and a treatment depth for at least one skin section of a user with reference to skin condition information including information about at least one of moisture content and wrinkles of the user's skin; a guide providing unit configured to provide the user with a guide for treatment based on the determined ultrasonic treatment map; and a monitoring management unit configured to monitor whether the user follows the guide with reference to treatment action information of the user according to the provided guide. 1. A system for supporting a skin treatment using ultrasound , comprising:a treatment map management unit configured to determine an ultrasonic treatment map of at least one of a treatment intensity, a treatment number and a treatment depth for at least one skin section of a user with reference to skin condition information including information about at least one of moisture content and wrinkles of the user's skin;a guide providing unit configured to provide the user with a guide for treatment based on the determined ultrasonic treatment map; anda monitoring management unit configured to monitor whether the user follows the guide with reference to treatment action information of the user according to the provided guide.2. The system of claim 1 ,wherein the treatment map management unit further refers to an ultrasonic treatment reference map related to profile information of the user to determine the ultrasonic treatment map.3. The system of claim 2 ,wherein the treatment map management unit specifies a treatment number for at least one skin section of the user based on the ultrasonic treatment reference map.4. The system of claim 1 ,wherein the treatment map management unit determines a treatment ...

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Номер записи: 90
28-03-2019 дата публикации

CATHETER WITH MULTIPLE ULTRASOUND RADIATING MEMBERS

Номер: US20190091458A1
Автор: ABRAHAMSON TIM, BARRERE WM. GERRIT, Cohen Amy, Genstler Curtis, KEILMAN GEORGE, OLIVER LEONARD R., PESKIN NATALYA, Wilcox Robert L., Wilson Richard R.
Принадлежит:

A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element. 1. (canceled)2. A catheter system for delivering ultrasonic energy to a treatment site , the catheter system comprising:a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end; and an electrical conductor, having a first flat portion and a second flat portion,', 'a first ultrasound transducer having a first portion, and', 'a second ultrasound transducer having a second portion;, 'an ultrasonic assembly positioned within the treatment zone, the ultrasonic assembly comprisingwherein the first portion of the first ultrasound transducer is mounted to the first flat portion of the electrical conductor and wherein the second portion of the second ultrasound transducer is mounted to the second flat portion of the electrical conductor.3. The catheter system of claim 2 , wherein the first portion of the first transducer and the second portion of the second transducer are mounted to the electrical conductor.4. The catheter system of claim 2 , wherein the first portion of the first transducer and the second portion of the second transducer are substantially ...

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Номер записи: 91
26-06-2014 дата публикации

Transmissive imaging and related apparatus and methods

Номер: US20140180092A1
Автор: Gregory L. Charvat, Jonathan M. Rothberg, Nevada J. Sanchez, Tyler S. Ralston
Принадлежит: Butterfly Network Inc

Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.

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Номер записи: 92
26-06-2014 дата публикации

Transmissive imaging and related apparatus and methods

Номер: US20140180112A1
Автор: Gregory L. Charvat, Jonathan M. Rothberg, Nevada J. Sanchez, Tyler S. Ralston
Принадлежит: Butterfly Network Inc

Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.

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Номер записи: 93
26-06-2014 дата публикации

Ultrasound transducer and uses thereof

Номер: US20140180197A1
Автор: Ariel Sverdlik, Or Shabtay
Принадлежит: Cardiosonic Ltd

According to some embodiments there is provided a method for controlling a treatment effect on blood vessel tissue during an ultrasonic treatment, the method comprising positioning an ultrasonic transducer device in the blood vessel lumen; controlling a treatment effect by controlling fluid flow, wherein controlling comprises deploying a fluid restrictor at a location relative to the transducer effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. According to some embodiments there is provided an ultrasonic transducer device sized for placement in a body lumen, and comprising a fluid restrictor effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. In some embodiments, the fluid is blood.

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Номер записи: 94
13-04-2017 дата публикации

LIGHT AND/OR ULTRASONIC TRANSDUCER DEVICE WITH ELECTRICAL STIMULATION

Номер: US20170100585A1
Автор: CASTEL DAWN, CASTEL JOHN C., HALL MICHAEL R.
Принадлежит: SONOVIA HOLDINGS LLC

A flexible device having a layered structure for delivering electrical stimulation and one or both of light and ultrasound to a skin surface is provided. The device is flexible so as to form a non-planar contact surface against the skin surface, and includes one or both of (a) a flexible light emitter layer positioned between two flexible conductive layers that emits light when driven by a power source and (b) a flexible ultrasound emitter layer positioned between two flexible conductive layers that produces ultrasound when driven by a power source. The device also includes a flexible electrical stimulation layer that functions as an electrode and is configured to provide electrical stimulation when driven by a power source. 1. A flexible device having a layered structure for delivering electrical stimulation and one or both of light and ultrasound to a skin surface , comprising:a plurality of flexible conductive layers connectable to a power source;one or both of (a) a flexible light emitter layer positioned between two of the flexible conductive layers, wherein the flexible light emitter layer is configured to emit light when driven by the power source and (b) a flexible ultrasound emitter layer positioned between two of the flexible conductive layers, wherein the flexible ultrasound emitter layer is configured to produce ultrasound when driven by the power source; anda flexible electrical stimulation layer connectable to the power source, wherein the flexible electrical stimulation layer functions as an electrode and is configured to provide electrical stimulation when driven by the power source.2. The device of claim 1 , wherein the flexible electrical stimulation layer functions as one of the flexible conductive layers.3. The device of claim 1 , wherein the flexible electrical stimulation layer is transparent such that the light passes through the flexible electrical stimulation layer to the skin surface.4. The device of claim 1 , wherein at least one of the ...

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Номер записи: 95
04-04-2019 дата публикации

MULTI-CHANNEL REAL-TIME PHASE MODULATION FOR EMI REDUCTION IN AN ULTRASOUND DEVICE

Номер: US20190099624A1
Автор: Kurtz Ron, Leonard Patrick, Zhang Xiaoyu
Принадлежит:

Methods for reducing electromagnetic interference arising from use of multiple ultrasound transducers in an array, particularly inside a human body that is inside a magnetic resonance imaging device. Electrical signals driving the transducers are offset in phase with respect to one another so as to achieve maximum offset of electrical and magnetic fields arising from such signals and transducers. Phase offsets are dynamically adjusted to respond to changes in driving amplitudes and frequencies so as to maintain optimal reduction of electromagnetic interference. 1. A method for reducing electromagnetic interference when operating an electrically-driven ultrasound thermal therapy apparatus , comprising:positioning said apparatus including an ultrasound array of said apparatus with respect to a specified treatment zone;in a computer-based host unit coupled to said therapy apparatus, determining a common driving frequency and determining an amplitude with which to drive each of a plurality of transducer elements of said array;driving each of said plurality of transducer elements with a respective driving signal generated by a respective voltage source, the driving signal for each element comprising said common driving frequency, said amplitude, and a respective phase angle; andmodifying the phase angle of at least one driving signal to reduce a net electromagnetic output of said thermal therapy apparatus.2. The method of claim 1 , wherein a first phase angle of a first driving signal and a second phase angle of a second driving signal are offset by 180 degrees.3. The method of claim 2 , wherein the first and second driving signals drive adjacent transducer elements.4. The method of claim 1 , wherein each phase angle is determined based claim 1 , at least in part claim 1 , on the amplitude of the corresponding driving signal.5. The method of claim 4 , wherein each phase angle is determined based claim 4 , at least in part claim 4 , on a vector dot product of each ...

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Номер записи: 96
21-04-2016 дата публикации

Reflectance-facilitated ultrasound treatment and monitoring

Номер: US20160107003A1
Автор: Liat Tsoref, Michael Kardosh, Yossi Gross
Принадлежит: Rainbow Medical Ltd

Apparatus comprising an ultrasound ablation system, which comprises a reflection-facilitation element, configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool, which comprises at least one ultrasound transducer configured to be positioned within a heart chamber of the subject. The ultrasound transducer is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

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Номер записи: 97
19-04-2018 дата публикации

Therapeutic ultrasound for eye disorder

Номер: US20180104514A1
Автор: Jimin Zhang, Michael Eric Gertner
Принадлежит: Olympic Ophthalmics Inc

Methods and devices are described which allow sound waves to be safely be applied to the eyelid of an eye of a patient or through the eyelid to other structures in the eye or to or through structures in the facial region to effect changes to one or more structures in and around the eye or directly through the cornea or sclera to regions of the eye to treat one or more diseases of the eye.

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Номер записи: 98
11-04-2019 дата публикации

DEVICES AND METHODS FOR MODULATING BRAIN ACTIVITY

Номер: US20190105517A1
Автор: Tyler William James
Принадлежит:

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions. 1. An ultrasonic method for modulating brain activity of a user , the method comprising:{'sup': 2', '2, 'stimulating one or more brain circuits of the user by delivering, from a wearable interface, transcranial ultrasound at an intensity of between 0.0001 mW/cmto about 100 W/cmand an ultrasound frequency in a range of about 0.02 MHz to about 10.0 MHz,'}wherein the wearable interface is worn on the user's head and includes at least one ultrasonic transducer; andmonitoring the user's brain activity during the stimulation of the one or more brain circuits.2. The method of claim 1 , further comprising determining claim 1 , in a controller coupled to the wearable interface claim 1 , a waveform emitted by the at least one ultrasound transducer.3. The method of claim 1 , wherein monitoring comprises any one of photoacoustic tomography claim 1 , functional near-infrared spectroscopy (fNIRS) claim 1 , magnetoencepholography (MEG) claim 1 , and electroencephalography (EEG).4. The method of claim 1 , wherein monitoring comprises monitoring the user's brain activity from one or more sensors on the wearable interface.5. The method of claim 1 , wherein monitoring comprises detecting specific thalamocortical oscillations.6. The method of claim 1 , further comprising transmitting information between the wearable interface and one or more remote processors.7. The method of claim 1 , further comprising transmitting instructions to the wearable interface to modulate one or ...

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Номер записи: 99
11-04-2019 дата публикации

ULTRASOUND DIRECTED CAVITATIONAL METHODS AND SYSTEM FOR OCULAR TREATMENTS

Номер: US20190105519A1
Автор: HEREKAR Rajeev, HEREKAR Satish
Принадлежит:

Methods and system provide a focused spot having a cross-sectional size within a range from about 50 um to about 200 um full width half maximum (FWHM); the corresponding cavitation can be similarly sized within similar ranges. The ultrasound beam can be focused and pulsed at each of a plurality of locations to provide a plurality of cavitation zones at each of the target regions. Each pulse may comprise a peak power within a range generating focal negative peak pressures within a range from about 10 MPa to about 80 MPa. While the treatment pulses can be arranged in many ways within a region, in many instances the pulses can be spaced apart within a region to provide intact tissue such as intact sclera between pulses. 1. A system for treating tissue of an eye , the system comprising:an ultrasound transducer array configured to generate a plurality of high intensity focused ultrasound (“HIFU”) pulses comprising a negative acoustic pressure within a range from about 10 Mega Pascal (MPA) to about 80 MPA; anda processor coupled to the ultrasound transducer array, the processor configured with instructions scan the plurality of pulses to a plurality of locations to treat the tissue of the eye, wherein the processor is configured with instructions to treat the eye with the HIFU beam to soften the tissue with a temperature increase to more than about 50 degrees Centigrade.2. A system as in claim 1 , wherein the tissue comprises transparent tissue and the processor is configured with instructions to scan the ultrasound beam to the plurality of locations to soften the tissue without opacifying the tissue.3. A system as in claim 2 , wherein the processor is configured to soften a target region of tissue with the plurality of pulses claim 2 , wherein a duty cycle of the plurality of pulses within the target region is within a range from about 0.1% to 1%.4. A system as in claim 2 , wherein the focused spot comprises a cross-sectional size within a range from 50 um to 200 um.5. A ...

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Номер записи: 100