METHOD FOR CONVERTING MONOISOCYANATES TO UREAS

Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets. 1. A method for converting an organic isocyanate comprising a phenyl isocyanate to one or more urea compounds in the presence of a non-polar organic solvent , comprising reacting a solution of the organic isocyanate in a liquid nonpolar solvent in the presence of at least 0.025 wt.-% of a organometallic catalyst , based on the weight of the organic isocyanate , wherein the organometallic catalyst includes at least one metal ion bonded to at least one organic ligand and the metal ion is selected from one or more of Co(II) , Mg(II) , Y(III) , Cr(III) and a lanthanide series metal ion in the 3+ oxidation state , to convert at least a portion of the organic isocyanate to the one or more urea compounds.2. The method of wherein the metal ion is Co(II) or Mg(II).3. The method of wherein at least one organic ligand is an arene ligand.4. The method of wherein the arene ligand is cyclopentadienyl or methylcyclopentadienyl.5. The method of wherein the metallic catalyst is one or more of bis(cyclopentadienyl) Co(II) claim 1 , bis(cyclopentadienyl) Mg(II) claim 1 , bis(cyclopentadienyl) Cr(II) claim 1 , tris(cyclopentadienyl) Gd(III) claim 1 , tris(cyclopentadienyl) Y(III) claim 1 , tris(cyclopentadienyl) La(III) claim 1 , tris(cyclopentadienyl Ru(III) claim 1 , bis(methylcyclopentadienyl) Co (II) claim 1 , bis(methylcyclopentadienyl) Mg(II) claim 1 , bis(methylcyclopentadienyl) Cr(II) claim 1 , tris (methylcyclopentadienyl) Gd(III) claim 1 , tris ( ...

THIXOTROPIC AGENT FOR CURABLE COMPOSITIONS

A thixotropic agent for increasing the yield point of a curable composition, wherein the thixotropic agent includes (i) at least one urea compound from the reaction of at least one isocyanate with at least one amine and (ii) at least one polyether having blocked hydroxyl groups. The thixotropic agent is preparable in a simple manner and forms a spreadable paste which is firm at room temperature. It is particularly suitable as a constituent of moisture-curing polyurethane or SMP compositions, giving a good increase in the yield point thereof, without adversely affecting storage stability or migration characteristics. It enables phthalate-free adhesives, sealants or coatings that have surprisingly good conveyability coupled with a high yield point, and do not cause any problems with odor or fogging. 1. A thixotropic agent for increasing the yield point of a curable composition , wherein the thixotropic agent comprises (i) at least one urea compound from the reaction of at least one isocyanate with at least one amine and (ii) at least one polyether having blocked hydroxyl groups which is free of urethane groups.3. The thixotropic agent as claimed in claim 1 , wherein the thixotropic agent takes the form of a spreadable paste which is firm at room temperature.4. The thixotropic agent as claimed in claim 1 , wherein 5% to 25% by weight of urea compounds and 50% to 95% by weight of polyethers having blocked hydroxyl groups are present.5. The thixotropic agent as claimed in claim 1 , wherein the polyether having blocked hydroxyl groups has a viscosity at 20° C. in the range from 30 to 500 mPa·s claim 1 , where the viscosity is determined with a cone-plate viscometer having cone diameter 25 mm claim 1 , cone angle 1° claim 1 , cone tip-plate distance of 0.05 mm claim 1 , at a shear rate of 10 s.6. The thixotropic agent as claimed in claim 1 , wherein the polyether has an average of 1 to 3 blocked hydroxyl groups per molecule.7. The thixotropic agent as claimed in claim 1 , ...

On-Demand Rapid Synthesis of Lomustine Under Continuous Flow Conditions

Disclosed herein is a continuous manufacturing process for lomustine that has a short residence time and 63 percent yield. Major advantages of this process are that the total production cost for lomustine is lower, the product is higher quality, and the manufacturing operation is safer for production personnel. 1. A method of producing Lomustine with continuous flow condition , wherein said Lomustine is prepared via a linear sequence of two chemical reactions performed separately in two telescoped flow reactors.3. A system for telescoped Lomustine synthesis , comprising sequentially:a first telescoping chamber mixing cyclohexylamine (1) and 1-chloro-2-isocyanatoethane (2) with triethyalamine (TEA) at 50 C for about 1 minute;a Zaiput liquid-liquid extractor to couple with the first telescoping chamber to remove the base TEA from the first reaction chamber; anda second telescoping chamber for nitrosation of the intermediate product 1-(2-chloroethyl)-3-cyclohexylurea (3) at 25 C for about 8 minutes using tBuONO (5) as the nitrosation agent. This invention was made with government support under CA023168 awarded by National Institutes of Health, and W911NF-16-2-0020 awarded by Army Research Laboratory. The government has certain right in the invention.This disclosure provides a novel method of synthesizing lomustine drug in scalable size under continuous flow conditions. Particularly, lomustine is prepared via a linear sequence of two chemical reactions performed separately in two telescoped flow reactors. The process omits isolation and purification of a labile intermediate, providing tremendous advantages of producing active pharmaceutical ingredient at low cost.Lomustine, a widely used anticancer agent, is a highly lipophilic alkylating agent that produces chloroethyl carbonium ions and carbamylating intermediates in vivo. These electrophilic compounds attack the nucleophilic sites on DNA to form alkylated products. Other anticancer agents such as mitomycin C, ...

Process for the preparation of polyisocyanates with a biuret structure

The present invention relates to an improved process for the preparation of polyisocyanates with a biuret structure by continuous reaction of excess amounts of organic diisocyanates having exclusively aliphatically and/or cycloaliphatically bonded isocyanate groups with organic diamines having exclusively aliphatically and/or cycloaliphatically bonded primary amino groups at elevated temperatures by 2-stage addition of the isocyanate component.

具有末端脲和/或氨基甲酸酯基团的新型碳二亚胺、用于生产所述碳二亚胺的方法、以及所述碳亚二胺的用途

本发明涉及新型的具有式(I)的碳二亚胺，这些碳二亚胺具有末端脲和/或氨基甲酸酯基团，其中R可以是相同的或不同的并且选自-NHCONHRˊ、-NHCONRˊR”和-NHCOOR”ˊ残基的组。本发明进一步涉及用于生产所述碳二亚胺的方法，以及所述碳二亚胺在以下各项中作为稳定剂的用途：基于酯的多元醇、聚对苯二甲酸乙二酯(PET)、聚对苯二甲酸丁二酯(PBT)、聚对苯二甲酸丙二酯(PTT)、共聚酯、热塑性聚酯弹性体(TPE-E)、乙烯乙酸乙烯酯(EVA)、聚乳酸(PLA)和/或PLA衍生物、聚对苯二甲酸己二酸丁二酯(PBAT)、聚琥珀酸丁二酯(PBS)、多羟基烷酸酯(PHA)、共混物、甘油三酯、热塑性聚氨酯、聚氨酯弹性体、PU粘合剂、PU铸模树脂、PU涂料或PU泡沫。

Novel carbodiimides with urea and/or urethane terminal groups, process for their preparation and their use

New carbodiimides having terminal urea and/or urethane groups, methods for producing same and use of same

Изобретение относится к карбодиимидам с концевыми уретановыми группами формулы (I), которые могут найти применение для защиты полимеров на основе сложных эфиров от гидролиза. В формуле (I) остатки R могут быть одинаковыми или разными и выбраны из групп -NHCOOR-, причем Rозначает (C-C)-алкил, (C-C)-циклоалкил или соответствует алкоксиполиоксиалкиленовому остатку, R, Rи Rнезависимо друг от друга означают метил или этил, причем каждое бензольное кольцо имеет всего одну метильную группу, n=0-20. Изобретение относится также к способам получения указанных карбодиимидов, содержащей их композиции для защиты полимеров на основе сложных эфиров от гидролиза, способу получения такой композиции и применению карбодиимидов в полиолах на основе сложных эфиров в качестве защиты от гидролитической деструкции. 7 н. и 12 з.п. ф-лы, 5 табл., 10 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 667 500 C2 (51) МПК C07C 267/00 (2006.01) C07C 271/28 (2006.01) C07C 273/18 (2006.01) C07C 275/40 (2006.01) C08G 18/02 (2006.01) C08K 5/29 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 267/00 (2006.01); C07C 271/28 (2006.01); C07C 273/1818 (2006.01); C07C 275/40 (2006.01); C08G 18/025 (2006.01); C08K 5/29 (2006.01) (21)(22) Заявка: 2015153209, 09.05.2014 09.05.2014 Дата регистрации: (73) Патентообладатель(и): ЛЭНКСЕСС ДОЙЧЛАНД ГМБХ (DE) 21.09.2018 (56) Список документов, цитированных в отчете о поиске: DE 2248751 A1, 12.04.1973. US 13.05.2013 EP 13167511.8 (43) Дата публикации заявки: 19.06.2017 Бюл. № 17 2941983 A, 21.06.1960. DE 10 2004 041605 A1, 02.03.2006. EP 0628541 A1, 14.12.1994. RU 2139852 C1, 20.10.1999. (45) Опубликовано: 21.09.2018 Бюл. № 27 C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 14.12.2015 (86) Заявка PCT: EP 2014/059578 (09.05.2014) (87) Публикация заявки PCT: 2 6 6 7 5 0 0 2 6 6 7 5 0 0 Приоритет(ы): (30) Конвенционный приоритет: R U R U (24) Дата начала отсчета срока действия патента: (72) ...

Preparation method of polyisocyanate with biuret structure

本发明涉及制备具有缩二脲结构的聚异氰酸酯的改进方法，该方法通过连续地将过量的具有专有地脂肪族和/或脂环族键合的异氰酸酯基的有机二异氰酸酯与具有专有地脂肪族和/或脂环族键合的伯胺基的有机二胺在高温下通过两步骤异氰酸酯组分添加反应。

Solid drug form of n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride and compositions, methods and kits related thereto

A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.

New herbicidal compositions and their preparation process

Addition of urea compounds to product liquids, e.g. to control the flow properties of resin binders for paint, involves reacting amine with isocyanate directly in the shear field of an in-line dissolver

A process for the addition of urea group-containing compounds (I) to product liquids, in which (I) are produced by bringing together and at least partly reacting (A) amines or amine-containing mixtures with (B) isocyanates or isocyanate-containing mixtures directly in a shear field. Independent claims are also included for (i) a dissolver, preferably an in-line dissolver (ILD), having a liquid feed pipe and an injector feed with an outlet leading directly into the shear field of the dissolver; (ii) a system with the following features for adding (I) to product liquids: (a) a loop with pumps for circulating the product liquid, (b) a dissolver (ILD as above) in the loop, (c) an isocyanate inlet in front of the ILD in the direction of flow and optionally (d) a heat exchanger in the loop in front of the ILD.

Patent RU2015153209A3

`7ВУ’” 2015153209`” АЗ Дата публикации: 14.03.2018 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 9 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2015153209/04(082014) 09.05.2014 РСТ/ЕР2014/059578 09.05.2014 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 13167511.8 13.05.2013 ЕР* Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) НОВЫЕ КАРБОДИИМИДЫ С КОНЦЕВЫМИ МОЧЕВИННЫМИ И/ИЛИ УРЕТАНОВЫМИ ГРУППАМИ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ Заявитель: РАЙН ХЕМИ РАИЙНАУ ГМБХ, ОЕ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. п см. Примечания [ ] приняты во внимание следующие пункты: р [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 267/00 (2006.01) С07С 273/18 (2006.01) С08С 18/02 (2006.01) С07С 271/28 (2006.01) С07С 275/40 (2006.0Т) СОбК 5/29 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 267/00, С07С 271/28, С07С 27318, С07С 275/40, С08@ 18/02, С08К 5/29 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): РЕРАТБ пес, РУ/РТ, ...

Novel carbodiimides having terminal urea and/or urethane groups, methods for the preparation thereof and use thereof

The invention relates to new carbodiimides having terminal urea and/or urethane groups of formula (I), wherein R can be the same or different and is selected from the group of the -NHCONHR', -NHCONR'R'', and -NHCOOR''' residues. The invention relates further to methods for producing said carbodiimides, and to the use of said carbodiimides as a stabilizer in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene terephthalate (PBT), in polytrimethylene terephthalate (PTT), in copolyesters, in thermoplastic polyester elastomers (TPE-Es), in ethylene vinyl acetate (EVA), in polylactic acid (PLA) and/or in PLA derivatives, in polybutylene adipate terephthalates (PBATs), in polybutylene succinates (PBSs), polyhydroxyalkanoates (PHAs), in blends, in triglycerides, in thermoplastic polyurethanes, in polyurethane elastomers, in PU adhesives, in PU casting resins, for PU coatings, or in PU foams.

Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl) methyl)urea hydrochloride and compositions, methods and kits related thereto

:1\Interwovn\NRPortbl\DCCSXD129404_l.docx-27/04/2020 A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4 (dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to "ATR 101") suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome. - 53-

Process for producing asymmetrically substituted ureas

Prepn. of non-symmetric substd. ureas (I) effected by reacting a gaseous mixt. of isocyanic acid and NH3 at 250-600 deg.C with a prim. or sec. amine. The reaction is pref. effected by either (a) introducing 1-7 (esp. 1.1-3) equivs. of the amine (pref. at 320-380 deg.C) into a gaseous isocyanic acid/NH3 mixt. and then cooling (pref. using an inert diluent) to condense (I); or (b) introducing a gaseous unisocyanic acid/NH3 mixt. at 250-600 deg.C into a primary or sec. amine which is in the liq. or molten state or in an inert diluent and then isolating (I) from the mixt.

Patent NO2997010T3

N-benzoyl-n'-trihalo-haloalkoxy-phenylureas,their preparation and the use thereof in pest control

There are disclosed novel substituted N-benzoyl-N'-2,3,5-trihalo-4- haloalkoxy-phenylureas of the formula I <IMAGE> in which R1 represents CF3, CF2CF3 or CF2CF2CF3, their preparation and intermediates for their preparation, their use in the control of pests, and pesticides which contain at least one compound of the formula I as active substance. The preferred field of application is the control of pests on animals and plants.

PROCEDURE FOR PREPARATION OF ASYMMETRICALLY SUBSTITUTED UREAS

POSTOPEK ZA PRIPRAVO NESIMETRIČNO SUBSTITUIRANIH SEČNIN s presnovo plinaste zmesi s temperaturo 250 do 600 C iz izocianove kisline in amoniaka s primarnim ali sekundarnim aminom.

Method of unsymmetrically substituted carbamides synthesis

Использование: в сельском хоз йстве. Сущность изобретени : усовершенствованный способ получени  несимметрично замещенных карбамидов. Реагент 1: газообразна  смесь изоциановой кислоты и аммиака, полученна  термическим пиролизом карбамида. Реагент 2: первичный или вторичный амин. Услови  реакции: температура 250-260&amp;deg;С, на 1 моль изоциановой кислоты примен ют по крайней мере 1 эквивалент амина. Цель: упрощение процесса . 5 з.п.ф-лы.

Process for the production of asymmetrically substituted ureas, carbamates, thiocarbamates and substituted isocyanates.

Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds.

Process for the preparation of asymmetrically substituted ureas

Prepn. of non-symmetric substd. ureas (I) effected by reacting a gaseous mixt. of isocyanic acid and NH3 at 250-600 deg.C with a prim. or sec. amine. The reaction is pref. effected by either (a) introducing 1-7 (esp. 1.1-3) equivs. of the amine (pref. at 320-380 deg.C) into a gaseous isocyanic acid/NH3 mixt. and then cooling (pref. using an inert diluent) to condense (I); or (b) introducing a gaseous unisocyanic acid/NH3 mixt. at 250-600 deg.C into a primary or sec. amine which is in the liq. or molten state or in an inert diluent and then isolating (I) from the mixt.

Thixotropic agents for curable compositions

本发明涉及用于提高可固化组合物的屈服点的触变剂，其中所述触变剂包含(i)由至少一种异氰酸酯与至少一种胺的反应获得的至少一种脲化合物和(ii)至少一种具有封闭羟基的聚醚。所述触变剂通过简单方法制得并且形成在室温下抗下垂的可涂抹的糊剂。所述触变剂特别适合用作湿固化聚氨酯组合物或SMP组合物的成分，有效提高其屈服点而不负面影响储存稳定性或迁移行为。所述触变剂能够实现不含邻苯二甲酸酯的粘合剂、密封剂或涂料，所述粘合剂、密封剂或涂料在高屈服点下令人惊讶地容易输送并且不会造成气味或起雾方面的问题。

"Gaschem " a urease and alpha-chymotrypsin enzyme inhibito ry drug

Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides

Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates and substituted isocyanates

Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds.

Process of production of non-symmetrically substituted ureas of carbamates or thiocarbamates or substituted isocyanates

Использование: В органическом синтезе . Сущность:- Усовершенствованный способ получени  несимметрично замещенных мочевин карбаматов, или тиокарбаматов или замещенных изоцианатов. Реагент 1; Аддукт изоциановой кислоты и третичного амина общей формулы RiR2RaNH NCO, где Ri.R2.R3 - независимо друг от друга линейный разветвленный низший алкил или фенил . Реагент 2: Первичный или вторичный амин, или спирт, или тиол, углеводородное соединение, содержащее одну или две не- куммулированные олефиновые двойные св зи. Услови  реакции: Органический растворитель , температура от минус 20&amp;deg;С до температуры кипени  растворител . Цель - упрощение процесса. 4 з.п.ф-лы. w Ё

Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides

The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.

Benzimidazolyl derivatives as kinase inhibitors

The present invention relates to benzimidazolyl derivatives of formula (I), with the definitions of R8, p, Ar1, E, D, R9, q and R10 according to claim 1, the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

carbodiimides with terminal urea and / or urethane groups; method for the production of carbodiimides; composition; method for producing the compositions; and use of carbodiimides

resumo carbodiimidas com grupos ureia e/ou uretano terminais; método para a produção das carbodiimidas; composição; método para a produção das composições; e uso das carbodiimidas a invenção se refere às novas carbodiimidas com grupos de ureia e/ou uretano terminais da fórmula (i), com r que pode ser igual ou diferente e é selecionado a partir do grupo dos radicais -nhconhri, -nhconririi- e -nhcooriii, métodos para a sua produção e seu uso como estabilizador em polióis à base de éster, em tereftalato de polietileno (pet), em tereftalato de polibutileno (pbt), em tereftalato de politrimetileno (ptt), em copoliésteres, em elastômeros de poliésteres termoplásticos (tpe e), em acetato de etilenovinila (eva), em ácido polilático (pla) e/ou em derivados de pla, em tereftalatos de polibutilenoadipato (pbat), em succinatos de polibutileno (pbs), em alcanoatos de polihidroxi (pha), em misturas, em triglicerídeos, em poliuretanos termoplásticos, em elastômeros de poliuretano, em adesivos de pu, em resinas de fundição de pu, para revestimentos de pu ou em espumas de pu. carbodiimides with terminal urea and / or urethane groups; method for the production of carbodiimides; composition; method for producing the compositions; and use of the carbodiimides The invention relates to the novel terminal urea and / or urethane carbodiimides of formula (I), wherein r may be the same or different and is selected from the group of -nhconhri, -nhconririi- and methods for their production and use as a stabilizer in ester-based polyols, polyethylene terephthalate (pet), polybutylene terephthalate (pbt), polytrimethylene terephthalate (ptt), copolyesters, elastomers of thermoplastic polyesters (tpe e), ethylenovinyl acetate (eva), polylactic acid (pla) and / or pla derivatives, polybutylenoadipate terephthalates (pbat), polybutylene succinates (pbs), polyhydroxy alkanoates ( pha), in mixtures, triglycerides, thermoplastic polyurethanes, polyurethane elastomers, pu adhesives, pu casting resins, ...

New carbodiimides having terminal urea and/or urethane groups, methods for producing said carbodiimides, and use of said carbodiimides

The invention relates to new carbodiimides having terminal urea and/or urethane groups of formula (I), wherein R can be the same or different and is selected from the group of the -NHCONHR', -NHCONR'R'', and -NHCOOR''' residues. The invention relates further to methods for producing said carbodiimides, and to the use of said carbodiimides as a stabilizer in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene terephthalate (PBT), in polytrimethylene terephthalate (PTT), in copolyesters, in thermoplastic polyester elastomers (TPE-Es), in ethylene vinyl acetate (EVA), in polylactic acid (PLA) and/or in PLA derivatives, in polybutylene adipate terephthalates (PBATs), in polybutylene succinates (PBSs), polyhydroxyalkanoates (PHAs), in blends, in triglycerides, in thermoplastic polyurethanes, in polyurethane elastomers, in PU adhesives, in PU casting resins, for PU coatings, or in PU foams.

Pharmaceutical compositions containing n-(aryloxyalkyl)-n'-(amino-alkyl)ureas or salts thereof and some such novel compounds

Process for the preparation of asymmetrically substituted ureas

Prepn. of non-symmetric substd. ureas (I) effected by reacting a gaseous mixt. of isocyanic acid and NH3 at 250-600 deg.C with a prim. or sec. amine. The reaction is pref. effected by either (a) introducing 1-7 (esp. 1.1-3) equivs. of the amine (pref. at 320-380 deg.C) into a gaseous isocyanic acid/NH3 mixt. and then cooling (pref. using an inert diluent) to condense (I); or (b) introducing a gaseous unisocyanic acid/NH3 mixt. at 250-600 deg.C into a primary or sec. amine which is in the liq. or molten state or in an inert diluent and then isolating (I) from the mixt.

N-(aryloxyalkyl)-n'-(aminoalkyl)ureas

N-(Aryloxyalkyl)-N'-(aminoalkyl)ureas and thioureas having the formula: wherein R1 and R2 each represent a hydrogen atom or a loweralkyl, cycloalkyl, phenyl or phenyllower alkyl group, and R3 and R4 each represent a hydrogen atom or a loweralkyl, phenyl or phenylalkyl group or R3 and R4 taken together with the adjacent nitrogen form a heterocyclic residue are disclosed for use in treating cardiac arrhythmias.

FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT AKTIVA N- (ARYLOXIALKYL) -N '- (AMINOALKYL) -UREAFOERENINGAR.

Process for producing asymmetrically substituted ureas

N-alkyl ureido anionic gemini surfactant and preparation method thereof

本发明公开了一种N‑烷基脲基阴离子型双子表面活性剂，其特征在于具有如下结构通式：

Quarternary amine carbamate or urea compounds based on isopropenyl-, alpha, alpha-dimethylbenzyl isocyanate

A meta- or para-compound of the formula:wherein: X⊖ is an anion selected fromthe group consisting of R₄OSO₃⊖ Cl⊖, Br⊖ and ⊖;wherein: n is 2 or 3;R₁, R₂ and R₃ which may be the same or different, are lower alkyl; andR₄ is lower alkyl or allyl.Also disclosed is a method of making the compound by reacting meta- or para-isopropenyl-a,a-dimethylbenzyl isocyanate with either an amino alcohol or a dialkylamino- ethyleneamine, and quaternizing the reaction product with an alkylating agent. The compound may be polymerized with a co-monomer such as acrylamide to yield water-soluble cationic polymers for use in water clarification, flocculation, and hair spray applications.

Process for the preparation of asymmetrically substituted ureas

Process for the preparation of asymmetrically substituted ureas by reaction of a gaseous mixture of isocyanic acid and ammonia having a temperature of 260° to 600° C. with a primary or secondary amine.

Process for preparing non-symmetrically substituted urea derivatives

Prepn. of non-symmetric substd. ureas (I) effected by reacting a gaseous mixt. of isocyanic acid and NH3 at 250-600 deg.C with a prim. or sec. amine. The reaction is pref. effected by either (a) introducing 1-7 (esp. 1.1-3) equivs. of the amine (pref. at 320-380 deg.C) into a gaseous isocyanic acid/NH3 mixt. and then cooling (pref. using an inert diluent) to condense (I); or (b) introducing a gaseous unisocyanic acid/NH3 mixt. at 250-600 deg.C into a primary or sec. amine which is in the liq. or molten state or in an inert diluent and then isolating (I) from the mixt.

Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl) methyl)urea hydrochloride and compositions, methods and kits related thereto

A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to "ATR-101") suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.

New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity

Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of these complexes for the treatment of tumors in mammals, are disclosed. The bis-platinum(II) Complexes are of formula (I):

Adducts of amine catalysts for making isocyanurate polymers

本发明涉及叔胺的氨基甲酸酯、硫代氨基甲酸酯和脲加合物及其作为用于脂族、脂环族、芳脂族或芳族键合的异氰酸酯基团的互相交联的催化剂的用途。根据本发明的催化剂具有特定优点在于它们是热潜伏性的。

New carbodiimides having terminal urea and/or urethane groups, methods for producing said carbodiimides, and use of said carbodiimides.

La invención se refiere a nuevas carbodiimidas con grupos urea y/o uretano terminales de fórmula (I), con R que puede ser igual o distinto y se selecciona del grupo de los restos - NHCONHRI, -NHCONRIRII y -NHCOORIII a procedimientos para su preparación y a su uso como estabilizador en polioles a base de éster, en poli(tereftalato de etileno) (PET), en poli(tereftalato de butileno) (PBT), en poli(tereftalato de trimetileno) (PTT), en copoliésteres, en elastómeros de poliésteres termoplásticos (TPE E), en etileno-acetato de vinilo (EVA), en poli(ácido láctico) (PLA) y/o en derivados de PLA, en poli(adipato de butileno-tereftalatos) (PBAT), en poli(succinatos de butileno) (PBS), en polihidroxialcanoatos (PHA), en combinaciones, en triglicéridos, en poliuretanos termoplásticos, en elastómeros de poliuretano, en adhesivos de PU, en resinas de moldeo de PU, para revestimientos de PU o en espumas de PU.

Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides

The present invention relates to carbamoylation of amines, mercaptanes, t hiophenols and phenols employing organic azides. More specifically, the inve ntion relates to a method for generating urea derivatives, thiocarbamate der ivatives and carbamate derivatives, and is based on the intermediate formati on of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers an d biomolecules.

ANTITUMOR-EFFECTIVE BIS-PLATINUM COMPLEXES WITH POLYMETHYLENE DERIVATIVES AS LIGANDS

n- (2,6-bis (1-methylethyl) phenyl) -N '- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride solid drug form and related compositions, methods and kits the same

resumo ?forma de fármaco sólida de cloridreto de n-(2,6-bis(1-metiletil)fenil)-n?-((1-(4-(dimetilamino)fenil)ciclopentil)metil)ureia e composições, métodos e kits relacionados à mesma? uma nova forma de fármaco sólida de cloridreto de n-(2,6-bis(1-metiletil)fenil)-n?-((1-(4-(dimetilamino)fenil)ciclopentil)metil)ureia (também referida ?atr-101?) adequada para dosagem oral, e composições, métodos e kits relacionados à mesma são descritos. atr-101 apresenta utilidade particular no tratamento, por exemplo, de atividade celular adrenocortical anormal, incluindo carcinoma adrenocortical (acc), hiperplasia adrenal congênita (cah) e síndrome de cushing. Summary - n- (2,6-bis (1-methylethyl) phenyl) -n '- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride solid drug form and compositions, methods and kits related to it? a new form of n- (2,6-bis (1-methylethyl) phenyl) -n '- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride solid drug (also referred to as above) -101 ') suitable for oral dosage, and related compositions, methods and kits are described. atr-101 has particular utility in treating, for example, abnormal adrenocortical cellular activity, including adrenocortical carcinoma (acc), congenital adrenal hyperplasia (cah), and cushing syndrome.

Verfahren zur herstellung von polyisocyanaten mit biuretstruktur

Method of converting carbon dioxide into carbonyl compounds

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Thixotropiermittel für härtbare zusammensetzungen

Bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity

Complexos de bis-platina com derivados de polimetileno como ligandos possuindo actividade antitumoral

New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity

Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden

Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden

有機溶液からモノイソシアネートを除去するための方法

从有机溶液中去除单异氰酸酯的方法

从在溶剂与聚异氰酸酯产物分离时获得的工艺流中去除单异氰酸酯杂质。所述单异氰酸酯与胺化合物以特定摩尔比反应以产生脲。所述脲可以通过燃烧、填埋或以其它方式丢弃。或者，所述脲可再循环回到聚异氰酸酯制造工艺中，其中所述脲形成为可与所述聚异氰酸酯产物一起保留的缩二脲化合物。

モノイソシアネートを尿素に変換するための方法

Method for converting monoisocyanates to ureas

Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets.

모노이소시아네이트를 요소로 전환하는 방법

유기 이소시아네이트는 소정 코발트, 마그네슘, 크롬 및 란탄 계열 유기금속 촉매의 존재 하에 가열에 의해 요소로 전환된다. 공정은 물 또는 다른 반응물을 필요로 하지 않는다. 공정은 폴리이소시아네이트 제조 공정으로부터 회수되는 용매 스트림으로부터 소량의 모노이소시아네이트를 제거하기 위해 특히 유용하다. 요소 화합물은 일부 경우에서 폴리이소시아네이트 제조 공정으로 다시 재활용되고 폴리이소시아네이트 화합물과 반응하여 뷰렛을 형성할 수 있다.

用于将单异氰酸酯转化为脲的方法

有机异氰酸酯是通过在存在某些钴、镁、铬和镧系有机金属催化剂的存在下加热转化为脲的。所述方法不需要水或其他反应物。所述方法对于从自聚异氰酸酯制造工艺回收的溶剂料流中去除少量的单异氰酸酯是特别有用的。在一些情况下，脲化合物能够被再循环回到所述聚异氰酸酯制造工艺中并且与聚异氰酸酯化合物起反应以形成缩二脲。

Method of converting carbon dioxide into carbonyl compounds

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by FIG. 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from −40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from −40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Method of converting carbon dioxide into carbonyl compounds

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Method of converting carbon dioxide into carbonyl compounds

Method for removing monoisocyanates from organic solution

Monoisocyanate impurities are removed from a process stream obtained when solvent is separated from a polyisocyanate product. The monoisocyanates are reacted with amine compounds at specific molar ratios to produce ureas. The ureas can be discarded by burning, landfilling or otherwise. Alternatively the ureas can be recycled back into the polyisocyanate manufacturing process, where they are formed into biuret compounds that can remain with the polyisocyanate product.

一种具有增稠作用的化合物和润滑脂以及它们的制备方法

本发明涉及润滑剂领域，公开了一种具有增稠作用的化合物和润滑脂以及它们的制备方法。所述化合物如式I所示。所述化合物的制备方法包括：将羟基脂肪酸的锂盐与多异氰酸酯、胺以及任选的另外的异氰酸酯反应以得到具有一个或多个‑NHCONH‑结构的化合物。本发明公开的润滑脂含有至少一种所述的化合物。制备润滑脂的方法包括：将羟基脂肪酸的锂盐与多异氰酸酯、胺以及任选的另外的异氰酸酯反应以得到具有一个或多个‑NHCONH‑结构的基团的化合物；将所得产物进行炼制，再与余量基础油和任选的添加剂混合。本发明提供了上述方法制得的润滑脂。本发明提供的化合物综合性能优良，能够同时提高润滑脂的各项性能。

1,1,3,5-치환뷰렛 화합물의 제조방법

내용 없음

Method for converting monoisocyanates to ureas

Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets.

用于将单异氰酸酯转化为脲的方法

有机异氰酸酯是通过在存在某些钴、镁、铬和镧系有机金属催化剂的存在下加热转化为脲的。所述方法不需要水或其他反应物。所述方法对于从自聚异氰酸酯制造工艺回收的溶剂料流中去除少量的单异氰酸酯是特别有用的。在一些情况下，脲化合物能够被再循环回到所述聚异氰酸酯制造工艺中并且与聚异氰酸酯化合物起反应以形成缩二脲。

从有机溶液中去除单异氰酸酯的方法

从在溶剂与聚异氰酸酯产物分离时获得的工艺流中去除单异氰酸酯杂质。所述单异氰酸酯与胺化合物以特定摩尔比反应以产生脲。所述脲可以通过燃烧、填埋或以其它方式丢弃。或者，所述脲可再循环回到聚异氰酸酯制造工艺中，其中所述脲形成为可与所述聚异氰酸酯产物一起保留的缩二脲化合物。

用于可固化组合物的触变剂

本发明涉及用于提高可固化组合物的屈服点的触变剂，其中所述触变剂包含(i)由至少一种异氰酸酯与至少一种胺的反应获得的至少一种脲化合物和(ii)至少一种具有封闭羟基的聚醚。所述触变剂通过简单方法制得并且形成在室温下抗下垂的可涂抹的糊剂。所述触变剂特别适合用作湿固化聚氨酯组合物或SMP组合物的成分，有效提高其屈服点而不负面影响储存稳定性或迁移行为。所述触变剂能够实现不含邻苯二甲酸酯的粘合剂、密封剂或涂料，所述粘合剂、密封剂或涂料在高屈服点下令人惊讶地容易输送并且不会造成气味或起雾方面的问题。

用于制备异氰脲酸酯聚合物的胺催化剂的加合物

本发明涉及叔胺的氨基甲酸酯、硫代氨基甲酸酯和脲加合物及其作为用于脂族、脂环族、芳脂族或芳族键合的异氰酸酯基团的互相交联的催化剂的用途。根据本发明的催化剂具有特定优点在于它们是热潜伏性的。

一种苯并五元、六元环(硫)脲催化剂及其在开环聚合中的应用

本发明公开了一系列含苯并五元、六元环(硫)脲催化剂及其在内酯单体开环聚合中的应用。本发明制备的(硫)脲催化剂和碱协同作用，在引发剂醇的存在下，催化内酯单体的开环聚合，得到具有不同拓扑结构的聚酯；在不加醇类引发剂的情况下，可以得到环状聚酯。根据不同的聚合反应条件可以获得结构可调、分子量可控、分子量分布窄的聚酯产物。该催化剂催化效率高，用量少，合成简单，反应条件较为温和，且在产物中无金属残留。应用其进行开环聚合具有工艺简便、成本低廉、反应速率高、过程可控、产物分子量分布窄等特点，且本体聚合溶液聚合均可实施。

Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride and compositions, methods and kits related thereto

A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.

Carbodiimides having terminal urea and/or urethane groups, methods for producing said carbodiimides, and use of said carbodiimides

The invention relates to novel carbodiimides having terminal urea and/or urethane groups, methods for the preparation thereof and use thereof as stabilizers in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene terephthalate (PET), in polytrimethylene terephthalate (PTT), in copolyesters, in thermoplastic polyester elastomers (TPE E), in ethylene vinyl acetate (EVA), in polylactic acid (PLA) and/or in PLA derivatives, in polybutylene adipate terephthalates (PBAT), in polybutylene succinates (PBS), in polyhydroxyalkanoates (PHA), in blends, in triglycerides, in thermoplastic polyurethanes, in polyurethane elastomers, in PU adhesives, in PU casting resins, for PU coatings or in PU foams.