19-09-2013 дата публикации
Номер: US20130243751A1
Принадлежит:
A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by 1. A conjugate molecule comprising an oligo- or polysaccharide selected from the group consisting of:{'sub': x', 'y, '(X)-{B(E)C}-(Y)'}{'sub': x', 'y, '(X)-{(E)CD}-*Y)'}{'sub': x', 'y, '(X)-{AB(E)C}-(Y)'}{'sub': x', 'y, '(X)-{B(E)CD}-(Y)'}{'sub': x', 'y, '(X)-{(E)CDA}-(Y)'}{'sub': x', 'y, '(X)-{DAB(E)C}n-(Y)'}{'sub': x', 'y, '(X)-{B(E)CDA}n-(Y)'}{'sub': x', 'y, '(X)-{(E)CDAB}n-(Y)'}{'sub': x', 'y, '(X)-{AB(E)CD}n-(Y)'}{'sub': x', 'y, '(X)-{DAB(E)CD}-(Y)'}{'sub': x', 'y, '(X)-{B(E)CDAB(E)C}-(Y)'}wherein:A is an alphaLRhap-(1,2) residueB is an alphaLRhap-(1,3) residueC is an alphaLRhap-(1,3) residueE is an alphaDGlcp-(1,4) residueD is a betaDGlcNAcp-(1,2) residuex and y are independently selected among 0 and 1X and Y are independently selected among A, B, C, D, E, AB, B(E), (E)C, CD, DA, AB(E), B(E)C, (E)CD, CDA, AB(E)C, B(E)CD, (E)CDA, CDAB, DAB(E) and wherein n is an integer comprised between 1 and 10 covalently bound to a carrier.2. A molecule according to wherein n is comprised between 2 and 6.3. A molecule according to wherein the carrier is selected among a protein or a peptide comprising at least one T-cell epitope claim 1 , or a derivative thereof.4. A molecule according to claim 3 , wherein the carrier is the peptide PADRE.5. A molecule according to claim 3 , wherein the carrier is the tetanus toxoid.6. A molecule according to claim 1 , wherein the carrier is biotin.7. A molecule according to claim 1 , wherein the saccharide is directly bound to the carrier.8. A molecule according to claim 1 , wherein the saccharide is bound to the carrier via a spacer.9. A molecule according to claim 1 , wherein the saccharide to carrier ratio is comprised between 1:1 and 30:1.10. A molecule according to claim 1 , wherein the saccharide is selected among the tetrasaccharides and pentasaccharides and their oligomers.11. A molecule ...
Подробнее
