Method for Quantitatively Measuring the Concentration of a Compound of Unknown Concentration in Solution

The present invention relates to methods of spectrophotometric determination of the presence of particular substances in a complex mixture of compounds. This invention relates to methods for determining the concentration of various components of complex biological samples including the determination of the concentration of polyoxyethylene containing compounds including polysorbate in protein containing samples as well as determining the ratio of drug to antibody ratios in antibody-drug conjugate solutions 1. A method for determining the concentration of a second compound in a solution comprising buffer and a first compound and a second compound comprising:a. collecting a set of optical density versus wavelength spectra at two or more path lengths of the buffer of a solution containing first compound only to produce a first buffer background spectra;b. collecting a set of optical density versus wavelength spectra at two or more path lengths for the solution containing first compound only;c. correcting the solution containing first compound spectra with the first buffer background spectra to produce a first compound background corrected spectra;d. selecting two or more data points at a first wavelength from the first compound background corrected spectra and performing linear regression on the data points to produce a first slope;e. selecting two or more data points at a second wavelength from the first compound background corrected spectra and performing linear regression on the data point to produce a second slope;f. calculating the ratio of the slopes at the first and second wavelengths for the first compound;g. collecting a set of optical density versus wavelength spectra at two or more path lengths of a buffer of a solution containing a known concentration of the second compound only to produce a second buffer background spectra;h. collecting a set of optical density versus wavelength spectra at two or more path lengths of a solution containing a known ...

SPECTROSCOPIC MEASURING DEVICE AND METHOD TO DETERMINE CONCENTRATIONS OF POLLUTANTS

The invention relates to a method for determining concentrations of absorbing gases by means of a spectroscopic measuring device, wherein wavelength-dependent measurement values for a light intensity are obtained and a wavelength-dependent measurement value function is represented based on these values. A wavelength-dependent theoretical function is defined, which includes as parameters a calibration parameter and the concentrations. The calibration parameter is defined as a function of a device parameter and a correction parameter that depends on the concentrations. A cycle comprising a sequence of steps is performed several times in a row, wherein in a first step a numerical value for the correction factor is calculated from stipulated assumed values of the concentrations, wherein in a second step the theoretical function is determined using the calculated numerical value, wherein in a third step values for the concentrations are obtained by a curve adjustment calculation between the theoretical function determined in the second step and the measurement value functions and are stipulated as new assumed values. The assumed values obtained in the third step of the last cycle are output as new measured values. 1. A method for determining at least one concentration of at least one absorbing gas in a gas mixture to be measured by means of a spectroscopic measuring device , which comprises a light source , a measuring cell comprising an optical resonator , a detector and a computer unit , wherein the gas mixture is arranged in the measuring cell and a light beam is sent to the measuring cell through an entrance of the measuring cell by means of the light source , wherein wavelength-dependent measurement values for a light intensity of light leaving from an exit of the measuring cell are obtained by means of the detector , wherein a wavelength-dependent shape of the light intensity is represented as a wavelength-dependent measurement value function and wherein a curve ...

Surgical visualization with proximity tracking features

A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

Multidimensional White Light Spectrometer

A multidimensional spectrometer provides broadband white light pump and probe pulses to allow acquisition of multidimensional spectral information over a wide range commensurate with solar-related chemical processes.

Methods for Determining Transition Metal Compound Concentrations in Multicomponent Liquid Systems

Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems and for improving methods of preparing the multicomponent catalyst system.

GAS ANALYSIS DEVICE, CONTROL SYSTEM AND CONTROL ASSISTANCE SYSTEM FOR COMBUSTION FACILITY, AND GAS ANALYSIS METHOD

A gas analysis device includes: a measurement part configured to measure an absorption amount of a laser light including an absorption wavelength corresponding to at least two electronic level transitions having the same component contained in the combustion gas, by emitting the laser light on a plurality of measurement paths disposed to pass through the combustion gas; a standard setting part configured to set a standard gas concentration distribution and a standard temperature distribution on the basis of a measurement result of the measurement part; and an analysis part configured to obtain the gas concentration distribution and the temperature distribution by solving a function including the gas concentration distribution and the temperature distribution as variables so as to minimize a difference between the absorption amount measured by the measurement part and a standard absorption amount obtained on the basis of the standard gas concentration distribution and the standard temperature distribution. 1. A gas analysis device for analyzing a concentration distribution of a combustion gas in a furnace and a temperature distribution inside the furnace , the gas analysis device comprising:a measurement part configured to measure an absorption amount of a laser light including an absorption wavelength corresponding to at least two electronic level transitions having the same component contained in the combustion gas, by emitting the laser light on a plurality of measurement paths disposed so as to pass through the combustion gas;a standard setting part configured to set a standard gas concentration distribution and a standard temperature distribution on the basis of a measurement result of the measurement part; andan analysis part configured to define the gas concentration distribution and the temperature distribution defined as a function including a common variable parameter and to obtain the gas concentration distribution and the temperature distribution by ...

Blood coagulation analyzer and blood coagulation analyzing method

A blood coagulation analyzer and analyzing method perform following: (a) preparing a measurement specimen by dispensing a blood specimen and a reagent into a reaction container; (b) emitting light of a plurality of wavelengths to the measurement specimen in the reaction container, the wavelengths comprising a first wavelength for use in a measurement by a blood coagulation time method, and at least one of a second wavelength for use in a measurement by a synthetic substrate method and a third wavelength for use in a measurement by an immunoturbidimetric method; (c) detecting light of a plurality of wavelengths corresponding to the light emitted in (b), from the measurement specimen, by a light receiving element, and acquiring data corresponding to each wavelength; and (d) conducting an analysis based on the data corresponding to one of the wavelengths among the acquired data, and acquiring a result of the analysis.

SAMPLE TEST METHOD, MICROFLUIDIC DEVICE, AND TEST DEVICE

A sample test method, microfluidic device, and test device efficiently and accurately compensates for interference of an interfering substance present in a sample using optical measurement without addition of a separate reagent for detecting the interfering substance. The sample test method includes: measuring an optical characteristic value of a target substance present in a sample; measuring an optical characteristic value of an interfering substance present in the sample; and determining a concentration of the target substance for which interference of the interfering substance is compensated for based on the optical characteristic value of the interfering substance. 1. A sample test method comprising:measuring an optical characteristic value of a target substance present in a sample;measuring an optical characteristic value of an interfering substance present in the sample; anddetermining a concentration of the target substance for which interference of the interfering substance is compensated for based on the optical characteristic value of the interfering substance.2. The sample test method of claim 1 , wherein the determining the concentration of the target substance for which interference of the interfering substance is compensated for comprises:compensating the optical characteristic value of the target substance using the optical characteristic value of the interfering substance; anddetermining the concentration of the target substance based on the compensated optical characteristic value.3. The sample test method of claim 2 , wherein the compensating the optical characteristic value of the target substance comprises:applying a fluctuation coefficient to the optical characteristic value of the interfering substance to obtain an application result, and then subtracting or adding the application result from or to the optical characteristic value of the target substance.4. The sample test method of claim 1 , wherein the measuring the optical characteristic ...

SAMPLE ANALYSIS METHODS

The invention generally relates to methods for determining a concentration of at least one target analyte in a heterogeneous sample and methods for detecting a condition. In certain aspects, the inventions provides methods that involve illuminating a heterogeneous sample, such as a biological sample, including at least one target analyte with polychromatic light, receiving luminous data of the heterogeneous sample and the at least one target analyte with a detector without splitting the polychromatic light into individual wavelengths and generating spectral data therefrom. The spectral data is then converted into a concentration of the at least one target analyte in the biological sample by comparing the spectral data to a database comprising known spectra already associated with concentration levels. 1. A method for determining a concentration of at least one target analyte in a heterogeneous sample , the method comprising:illuminating a heterogeneous sample comprising at least one target analyte with polychromatic light;receiving a luminous signal of the heterogeneous sample and the at least one target analyte with a detector without splitting the polychromatic light into individual wavelengths;generating spectral data from the received luminous signal; andconverting the spectral data into a concentration of the at least one target analyte in the heterogeneous sample by comparing the spectral data to a database comprising known spectra already associated with concentration levels of the target analyte.2. The method of claim 1 , wherein the heterogeneous sample is at least one selected from the group consisting of a biological sample claim 1 , an environmental sample claim 1 , a food product sample claim 1 , and a beverage product sample.3. The method of claim 2 , wherein the biological sample is a human tissue or body fluid sample4. The method of claim 3 , wherein the body fluid sample is a blood sample.5. The method of claim 2 , wherein the body fluid sample is a ...

FERMENTATION GAS SENSOR SYSTEM

A gas sensor system for use in an exhaust gas tube, the system having at least two separate optical sensor assemblies that are separately positioned across the exhaust gas tube from one another, wherein the optical sensor assemblies each comprise a pair of light sources and a pair of light receivers such that light from each of the multiple light sources is received by each of the four light receivers, thereby generating multiple sets of optical measurements. 2. The gas sensor system of claim 1 , wherein:the first and second light sources in the first optical sensor assembly direct light to the first and second light receivers in the second optical sensor assembly, andthe first and second light sources in the second optical sensor assembly direct light to the first and second light receivers in the first optical sensor assembly.3. The gas sensor system of claim 2 , wherein:the first and second optical sensor assemblies generate four sets of optical measurements.4. The gas sensor system of claim 1 , wherein the first and second optical sensor assemblies are mounted on separate printed circuit boards.5. The gas sensor system of claim 1 , wherein the first and second optical sensor assemblies further comprise:a static pressure sensor;a dynamic pressure sensor; anda temperature sensor.6. The gas sensor system of claim 1 , wherein the first and second optical sensor assemblies further comprise:a methane sensor; andan acetic acid sensor.7. The gas sensor system of claim 1 , wherein each of the first and second sensor assemblies further comprise:a microcontroller;a power supply; anda wired or wireless data transmitter configured to transmit measured data to the Cloud.8. The gas sensor system of claim 1 , wherein a third sensor assembly is positioned intermediate the first and second sensor assemblies on the inner side of the exhaust gas tube.9. The gas sensor system of claim 1 , wherein the first and second light sources in each optical assembly comprise at least one of:a ...

SLOPE SPECTROSCOPY STANDARDS

The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements. 1. A method of making a slope spectroscopy standard for a compound comprising:selecting a compound;determining the slope at a predetermined concentration of the compound;determining a concentration of a standard which corresponds to the compound slope by using variable path length spectroscopy wherein the compound and the standard are different compounds and wherein the compound and the standard have absorbance spectra that share a common absorbance wavelength; andmaking a standard of an appropriate concentration which provides a slope measurement that corresponds to that of the compound.2. The method of wherein the standard is in an aqueous solution.3. The method of wherein the standard has a slope measurement of from about 0.01 to 500.4. The method of wherein the standard has a slope measurement of from about 1 to 500.5. The method of wherein the standard is a methylxanthine.6. The method of claim 5 , wherein the methylxanthine is selected from the group consisting of caffeine claim 5 , aminophylline claim 5 , IBMX claim 5 , paraxanthine claim 5 , pentoxifylline claim 5 , theobromine claim 5 , and theophylline7. The method of wherein the methylxanthine is caffeine.8. The method of wherein the standard is selected from the group consisting of NaCl claim 1 , KHP claim 1 , KCl and KCrO.9. The slope spectroscopy standard of wherein the standard has an uncertainty value of from about 0.1% to about 5%.10. A method of making a slope spectroscopy standard for a combination of a particular ratio of first compound to second compound in a combination of compounds comprising:determining the ratio of the first compound to the second compound in a combination of the compoundsdetermining a concentration of first substance which absorbs ...

DRIED BLOOD SAMPLE ANALYSIS

A non-destructive method of estimating hematocrit (Hct) of whole blood from a dried blood sample prepared from the whole blood, the method comprising: a) determining the amount of hemoglobin derivatives comprising oxyhemoglobin, methemoglobin and hemichrome (total hemoglobin) in a dried blood sample, wherein the sum of the amounts of the hemoglobin derivatives remains constant in the dried blood sample in function of time, and b) estimating the hematocrit from the sum of the amounts of the hemoglobin derivatives, wherein the hematocrit is estimated using a calibration curve providing a correlation between hematocrit and the amount of the hemoglobin derivatives in a dried blood sample. The amount of the hemoglobin derivatives is preferably determined by measuring the reflectance, absorbance, or transmittance of the dried blood sample at the quasi-isosbestic point of the hemoglobin derivatives about 589 nm or at multiple wavelengths within the range of 450 to 750 nm. 124-. (canceled)25. A non-destructive method of estimating hematocrit (Hct) of whole blood from a dried blood sample prepared from the whole blood , the method comprising: wherein the total amount of said hemoglobin derivatives in a dried blood sample is determined by measuring the reflectance, absorbance, or transmittance of the dried blood sample at the quasi-isosbestic point of said hemoglobin derivatives, or', 'wherein the total amount of said hemoglobin derivatives in a dried blood sample is determined by calculating the sum of the amounts of each of oxyhemoglobin, met-hemoglobin and hemichrome, wherein the amount of each of oxyhemoglobin, met-hemoglobin and hemichrome is determined by measuring the reflectance, absorbance, or transmittance of the dried blood sample at multiple wavelengths, and comparing the measured spectrum with reference spectra of the respective hemoglobin derivatives; and, 'a) determining the total amount of hemoglobin derivatives comprising oxyhemoglobin, met-hemoglobin and ...

PHOTOABSORPTION MICROSCOPY USING ELECTRON ANALYSIS

A method for chemical identification of a sample having nanostructures includes the steps of irradiating the surface at wavelengths for each of a first and a second of the nanostructures that are uniquely absorbed by each of the first nanostructure and the second nanostructure such that each is excited to modulate at a first or a second nanostructure frequency, respectively. The method continues with the steps of irradiating the surface with electron beams incident on each of the first and second nanostructure, wherein at least one of secondary electrons, backscattered electrons and transmitted electrons are modulated at the frequency corresponding to each of the first and second nanostructure frequencies. A chemical map of the sample at an atomic scale is then created. A microscope is provided to carry out the method. 1. A method for chemical identification of a surface of a sample having a plurality nanostructures , each nanostructure having different radiation absorption spectra , the method comprising:(a) irradiating the surface at a first wavelength for a first of said plurality of nanostructures that is uniquely absorbed by the first nanostructure such that the first nanostructure is excited to modulate at a frequency corresponding to the first nanostructure frequency;(b) irradiating the surface at a second wavelength for a second of said plurality of nanostructures that is uniquely absorbed by the second nanostructure such that the second nanostructure is excited to modulate at a frequency corresponding to the second nanostructure;(c) irradiating the surface with an electron beam, wherein when the electron beam is incident on the first nanostructure, wherein at least one of secondary electrons, backscattered electrons and transmitted electrons are modulated at the frequency corresponding to the first nanostructure frequency;(d) irradiating the surface with the electron beam, wherein when the electron beam is incident on the second nanostructure, wherein at ...

ZINC AND COPPER MEASUREMENT

An embodiment provides a method for measuring zinc and copper in an aqueous sample, including: reducing an aqueous sample containing an amount of zinc and an amount of copper with a reducing agent; buffering the reduced aqueous sample; chelating the amount of copper in the buffered aqueous sample with a copper(I) chelating agent; measuring the amount of copper in the aqueous sample by measuring a first change in intensity of the absorbance of the copper chelated aqueous sample; chelating the amount of zinc in the buffered aqueous sample with a zinc(II) chelating agent; and measuring the amount of zinc in the aqueous sample by measuring a second change in intensity of the absorbance of the zinc chelated aqueous sample. Other aspects are described and claimed. 1. A method for measuring zinc and copper in an aqueous sample , comprising:reducing an aqueous sample containing an amount of zinc and an amount of copper with a reducing agent;buffering the reduced aqueous sample;chelating the amount of copper in the buffered aqueous sample with a copper(I) chelating agent;measuring the amount of copper in the aqueous sample by measuring a first change in intensity of the absorbance of the copper chelated aqueous sample;chelating the amount of zinc in the buffered aqueous sample with a zinc(II) chelating agent; andmeasuring the amount of zinc in the aqueous sample by measuring a second change in intensity of the absorbance of the zinc chelated aqueous sample.2. The method of claim 1 , wherein the reducing agent comprises sodium ascorbate.3. The method of claim 1 , wherein the buffer comprises Tris(hydroxymethyl)aminomethane.4. The method of claim 1 , wherein the copper(I) chelating agent comprises bicinchoninic acid.5. The method of claim 1 , wherein the first change in intensity of the absorbance is proportional to a concentration of the amount of copper in the aqueous sample.6. The method of claim 1 , wherein the zinc(II) chelating agent comprises 2-Carboxy-2′-hydroxy-5′- ...

MANUFACTORING PROCESS FOR INTEGRATED COMPUTATIONAL ELEMENTS

Disclosed are methods of fabricating an integrated computational element for use in an optical computing device. One method includes providing a substrate that has a first surface and a second surface substantially opposite the first surface, depositing multiple optical thin films on the first and second surfaces of the substrate via a thin film deposition process, and thereby generating a multilayer film stack device, cleaving the substrate to produce at least two optical thin film stacks, and securing one or more of the at least two optical thin film stacks to a secondary optical element for use as an integrated computational element (ICE). 1. A method , comprising:providing a substrate;depositing multiple optical thin films on a surface of the substrate via a thin film deposition process and thereby generating an optical thin film stack;removing at least a portion of the substrate from the optical thin film stack; andsecuring the optical thin film stack to a secondary optical element for use as an integrated computational element (ICE).2. The method of claim 1 , wherein the substrate is planar.3. The method of claim 2 , wherein the substrate is at least one of mica claim 2 , pyrolitic carbon claim 2 , graphite claim 2 , and graphene.4. The method of claim 1 , wherein depositing the multiple optical thin films on the substrate is preceded by preparing the surface of the substrate either chemically or mechanically.5. The method of claim 1 , wherein securing the optical thin film stack to the secondary optical element is preceded by subdividing the optical thin film stack into multiple optical thin film stacks.6. The method of claim 1 , wherein removing the at least a portion of the substrate from the optical thin film stack is preceded by securing the optical thin film stack to the secondary optical element.7. The method of claim 6 , further comprising chemically reacting the substrate and thereby melting a target surface of the secondary optical element to bond ...

METHODS OF ASSESSING ANTIBODY-DRUG CONJUGATES

The present disclosure provides methods of assessing DAR of ADC products that provide advantages over known methods. Specifically, methods of the disclosure can be used in high-throughput applications and/or without having to dilute ADC samples during the assessment. 3. A method of determining a ratio of drug to antibody (DAR) in a sample comprising an antibody-drug conjugate , comprising:placing the sample in a vessel;moving a probe relative to the vessel such that the probe makes contact with the bottom of the vessel;moving the probe relative to the vessel such that the probe moves from the bottom of the vessel through the sample by a predetermined increment such that a preselected path length through the solution is obtained;detecting absorbance of the sample at a first light wavelength (λ1), wherein the first wavelength is a predetermined absorbance maxima of the antibody;repeating steps of moving the probe relative to the sample and taking a measurement at the first wavelength;generating a regression line from the absorbance at the first wavelength and path length such that a slope of the regression line is obtained;determining the concentration of the antibody by dividing the slope of the regression line by an extinction coefficient of the antibody at the first wavelength;detecting absorbance of the sample at a second light wavelength (λ2), wherein the second wavelength is a predetermined absorbance maxima of the drug;repeating steps of moving the probe relative to the sample and taking a measurement at the second wavelength;generating a regression line from the absorbance at the second wavelength and path length such that a slope of the regression line is obtained;determining the concentration of the drug by dividing the slope of the regression line by an extinction coefficient of the drug at the second wavelength; andcalculating a DAR using the determined concentration of drug and the determined concentration of antibody. This application claims priority to ...

SIMULTANEOUS MEASUREMENT OF MULTIPLE ANALYTES OF A LIQUID ASSAY

Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined. 1. An analyzer , comprising:a housing surrounding a test cartridge space sized and configured to receive a test cartridge containing a liquid test sample—reagent mixture configured to undergo an immunotype reaction;a first light source generating a first beam of light passing through the test cartridge space, the first beam of light having a first wavelength range;a second light source generating a second beam of light passing through the test cartridge space, the second beam of light having a second wavelength range different from the first wavelength range;a third light source generating a third beam of light passing through the test cartridge space, the third beam of light having a third wavelength range different from the first and second wavelength range;at least one sample detector positioned to receive one or more of the first, second and third beams of light subsequent to the first, second and third beams of light passing through the test cartridge space to generate first, second and third signals; anda computer system having a processor configured to:receive the first, second, and third signal indicative of light captured by the sample detector at first, second and third instants of time from the first, second and third light sources and to use the first, second, and third signals with calibration data to determine an amount of at least two analytes of interest simultaneously within the liquid test sample-reagent mixture.2. The ...

Photoacoustic Chemical Detector

A laser vibrometer for measurement of ambient chemical species includes a laser that produces a beam that is split into a reference readout beam and a signal readout beam. A probe laser beam is tuned to an absorption feature of a molecular transition, and generates acoustic signals when incident on a gaseous species via the photo acoustic effect. The scattered acoustic signals are incident on a thin membrane that vibrates. The readout laser beam reflected from the vibrating membrane is mixed with the reference beam at the surface of a photo-EMF detector. Interferrometric fringes are generated at the surface of the photo-EMF detector. Electric current is generated in the photo-EMF detector when the fringes are in motion due to undulations in the signal readout beam imparted by the vibrating membrane. A highly sensitive photo-EMF detector is capable of detecting picoJoules or less laser energy generated by vibrating processes. 111-. (canceled)12. A laser vibrometer capable of detecting chemical species , comprising: an external probe beam, having a wavelength corresponding to an absorption feature of the chemical species to be detected;', 'a reference beam; and', 'a sensing beam,, 'a light source configured to produce a beams of monochromatic light includinga pressure-sensing diaphragm which when impacted by the pressure waves resulting from the external probe beam interacting with a chemical species that is located away from the sensing beam responsively vibrates;a photo-electromotive force (photo-EMF) sensor;wherein the sensing beam is directed against the second side of the pressure sensing diaphragm; andwherein the sensing beam is directed to the photo-EMF sensor from the pressure-sensing diaphragm which photo-EMF sensor outputs a signal corresponding to the displacement of the diaphragm caused by the incident pressure wave.13. The laser vibrometer of claim 12 , wherein the light source includes:a laser configured to produce a beam of monochromatic light having a ...

LIMULUS AMOEBOCYTE LYSATE ASSAY AND METHOD OF SAME

A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used. 1. A Limulus Amoebocyte Lysate (LAL) assay system comprising means for measuring endotoxins in an analyte by monitoring changes in a refractive index of the analyte.2. The LAL assay system of claim 1 , wherein the means for measuring endotoxins comprise a photonic crystal biosensor.3. The LAL assay system of claim 1 , wherein the means for measuring endotoxins comprise a photonic crystal total internal reflection (PC-TIR) biosensor.4. The LAL assay system of claim 3 , further comprising at least one analyte well associated with the PC-TIR biosensor.5. The LAL assay system of claim 3 , further comprising means for providing polarized light to the PC-TIR biosensor.6. The LAL assay system of claim 4 , further comprising a prism for transmitting light to the PC-TIR biosensor and passing the light from the PC-TIR biosensor to a spectrometer for receiving the transmitted light.7. The LAL assay system of claim 5 , further comprising:a light source having a polarizer optically coupled thereto;a beam splitter optically coupled to the polarizer;a prism optically coupled to at least one of a plurality of analyte wells associated with the PC-TIR biosensor; anda spectrometer optically coupled to the prism.8. The LAL assay system of wherein an optical fiber optically couples the light source to the polarizer.9. The LAL assay system of claim 3 , wherein the PC-TIR biosensor further comprises a plurality of microchannels on a surface thereof.10. ...

Device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis

The invention relates to a device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis.

DEVICE AND METHOD FOR DETERMINING A WAVELENGTH OF A RADIATION

The invention relates to a device and a method for determining a wavelength of radiation. 1101214121416. A device () for determining a wavelength of radiation comprising at least two absorption elements ( , ) for generating photosignals , wherein the absorption elements ( , ) are arranged in a layer structure () one above the other ,characterized in that{'b': 12', '14, 'an upper absorption element () has a vertically varying chemical composition, which is characterized by a material gradient in order to set a wavelength-dependent absorption coefficient, and a lower absorption element () is designed to be chemically homogeneous.'}210. The device () according to claim 1 ,characterized in that{'b': 12', '14, 'the absorption elements (, ) comprise at least one semiconductor material.'}310. The device () according to or claim 1 ,characterized in that{'b': 12', '14, 'the absorption elements (, ) comprise binary, ternary, or quaternary alloys of semiconductors, preferably direct semiconductors.'}410. The device () according to any one or more of the preceding claims claim 1 ,characterized in that{'b': '12', 'the material gradient is varied monotonically rising or falling vertically, wherein the material gradient preferably has a linear or quadratic dependence on the vertical position within the upper absorption element ().'}510. The device () according to any one or more of the preceding claims claim 1 ,characterized in that{'b': '12', 'the material gradient in the upper absorption element () is formed by a vertical variation of the proportions of the alloy partners of a semiconductor alloy.'}610. The device () according to any one or more of the preceding claims claim 1 ,characterized in that{'b': '12', 'sub': x', '1-X, 'the upper absorption element () comprises a semiconductor alloy of the general form AB, wherein A and B each characterize alloy partners and x is the proportion of A in the semiconductor alloy which is vertically varied.'}710. The device () according to ...

Controlling plant detection systems using phase delay analysis

Methods for controlling a plant detection system include determining a target phase delay based on a first phase delay of reflected portions of a first light beam and a second phase delay of reflected portions of a second light beam. A composite light beam comprising the first light beam and the second light beam is emitter towards bare soil, and reflected portions of the composite light beam are detected. An intensity of at least one of the first light beam or the second light beam is adjusted so that a phase delay of the composite light beam is approximately equal to the target phase delay.

SHORT PULSEWIDTH REPETITION RATE NANOSECOND TRANSIENT ABSORPTION SPECTROMETER

A high-sensitivity nanosecond to millisecond transient absorption spectrometer for measurements of miniscule signals under low excitation intensities includes an excitation source generating a frequency greater than 100 Hz, pulsewidth less than 5 ns excitation pulse for exciting a light absorbing sample, a probe light source for generating a photon flux probe light beam producing an average irradiance greater than 1 μW mnmfor measuring the transient absorption spectrum of the sample before and after excitation by the excitation source, a DC-coupled detector capable of measuring light for enabling synchronous measurement of both the transmission of the probe light beam and the change in transmission of the probe light beam between a signal with the excitation pulse present and a signal in the absence of the excitation pulse, and a digital oscilloscope with a trigger rearm time capable of collecting every trigger event at high frequencies including 1 MHz, for enabling sequential noise subtraction protocols. 1. A high-sensitivity nanosecond to millisecond transient absorption spectrometer for measurements of miniscule signals under low excitation intensities , comprising:an excitation source generating an excitation pulse for exciting a light absorbing sample;a probe light source generating a probe light beam for measuring a transient absorption spectrum of the sample by monitoring transmission signals of the probe light beam before and after excitation by the excitation pulses;a detector for detecting the transmission signals and a change in the transmission signals of the probe light beam; anda digital oscilloscope for collecting the detected signals; the excitation pulse has a frequency greater than 100 Hz and a pulsewidth less than 5 ns;', {'sup': −2', '−1, 'the probe light beam has a photon flux producing an average irradiance greater than 1 μW mnm'}, 'the detector is a DC-coupled detector operable to measure light for enabling sequential switching of an AC- and ...

METHODS OF ASSESSING ANTIBODY-DRUG CONJUGATES

The present disclosure provides methods of assessing DAR of ADC products that provide advantages over known methods. Specifically, methods of the disclosure can be used in high-throughput applications and/or without having to dilute ADC samples during the assessment. 1. A method of determining a ratio of drug to antibody (DAR) in a sample comprising an antibody-drug conjugate , comprising:placing the sample in a vessel;contacting a probe with the bottom of the vessel;moving the probe from the bottom of the vessel through the sample by a predetermined increment such that a preselected path length through the solution is obtained;detecting absorbance of the sample at a first light wavelength (λ1), wherein the first wavelength is a predetermined absorbance maxima of the antibody;repeating steps of moving the probe relative to the sample and taking a measurement at the first wavelength;generating a regression line from the absorbance at the first wavelength and path length such that a slope of the regression line is obtained;determining the concentration of the antibody by dividing the slope of the regression line by an extinction coefficient of the antibody at the first wavelength;detecting absorbance of the sample at a second light wavelength (λ2), wherein the second wavelength is a predetermined absorbance maxima of the drug;repeating steps of moving the probe relative to the sample and taking a measurement at the second wavelength;generating a regression line from the absorbance at the second wavelength and path length such that a slope of the regression line is obtained;determining the concentration of the drug by dividing the slope of the regression line by an extinction coefficient of the drug at the second wavelength; andcalculating a DAR using the determined concentration of drug and the determined concentration of antibody.2. The method of claim 1 , wherein the size exclusion chromatography comprises ultra-performance liquid chromatography (UPLC) claim 1 , a ...

RESIDUAL TOXICANT DETECTION DEVICE

Disclosed is a residual toxicant detection device for detecting the amount of residual toxicants in an aqueous solution to be measured. The residual toxicant detection device includes an accommodation space formed from a shell, a water inlet and a water outlet positioned on the shell for the aqueous solution to flow therein and thereout, respectively, a sensing chamber in the accommodation space, a light source emitter and a light sensor positioned near the sensing chamber, the light source emitter emitting light of a wavelength range, the light sensor receiving the light passing through the sensing chamber, and a circuit board receiving sensing signals sensed by the light sensor, such that absorbance and a change of the absorbance of residual toxicants in the aqueous solution to be measured are calculated. 1. A device for detecting a residual toxicant in an aqueous solution to be measured , the device comprising:a shell including an accommodation space;a water inlet formed on the shell and in communication with the accommodation space, and configured for the aqueous solution to be measured to flow into the accommodation space;a sensing chamber provided in the accommodation space and configured for the aqueous solution to be measured to flow therein;a light source emitter provided near the sensing chamber and configured to emit light passing through the sensing chamber;a light sensor provided near the sensing chamber and configured to sense the light passing through the sensing chamber to produce a sensing signal;a water outlet formed on the shell and in communication with the accommodation space, and configured for the aqueous solution to be measured to flow out of the accommodation space; anda circuit board electrically connected with the light sensor and configured to receive the sensing signal.2. The device of claim 1 , wherein the circuit board is configured to calculate absorbance of the residual toxicant in the aqueous solution to be measured based on the ...

OPTICAL INSPECTION METHOD, OPTICAL INSPECTION DEVICE, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM STORING OPTICAL INSPECTION PROGRAM

According to one embodiment, an optical inspection method acquires, for an image point imaged through separating light from an object point into beams of light in at least two different and independent wavelength ranges, a hue vector having, as independent axes, intensities of the beams of light in the at least two different and independent wavelength ranges. The method then acquires, from the hue vector, information regarding a ray direction of the light from the object point. 1. An optical inspection method comprising:acquiring, for an image point imaged through separating light from an object point into beams of light in at least two different and independent wavelength ranges, a hue vector having, as independent axes, intensities of the beams of light in the at least two different and independent wavelength ranges; andacquiring, from the hue vector, information regarding a ray direction of the light from the object point.2. The optical inspection method according to claim 1 , further comprisingseparating the light from the object point into beams of light in at least two different wavelength ranges before separating into the beams of light in the at least two different and independent wavelength ranges.3. The optical inspection method according to claim 1 , whereinthe imaging of the image point is performed by an N-plate camera (N is an integer of two or more).4. The optical inspection method according to claim 1 , wherein claim 1 ,the acquiring the hue vector and the acquiring the information are performed for each pixel of an image imaged by an irradiation field formed by irradiating an object with beams of light in at least two different wavelength ranges.5. The optical inspection method according to claim 2 , wherein claim 2 ,the separating the light from the object point into the beams of light in the at least two different wavelength ranges is performed by a ray direction selection unit including a plurality of different and concentric selection areas ...

DEVICE AND A METHOD FOR LIGHT-BASED ANALYSIS OF A SUBSTANCE IN A LIQUID SAMPLE

A device for light-based analysis of a substance in a liquid sample comprises: an analysis cell for holding the liquid sample; wherein the analysis cell comprises a first wall portion for passing light generated by a light source into the analysis cell, and a second wall portion for passing light from the analysis cell to a light detector; and a plunger configured for movement along walls of the analysis cell for allowing entry of the liquid sample into the analysis cell and pushing the liquid sample out of the analysis cell; wherein at least one wiper is arranged on the plunger for cleaning the first and second wall portions during movement of the plunger. 1. A device for light-based analysis of a substance in a liquid sample , said device comprising:an analysis cell for holding the liquid sample during analysis;an inlet and outlet for transporting the liquid sample to and from the analysis cell;a light source for generating light for illuminating the liquid sample in the analysis cell;a light detector for detecting light, wherein the light detector and the light source are arranged on opposite sides of the analysis cell such that the light detector is configured to detect light having passed through the liquid sample;wherein the analysis cell comprises a first wall portion associated with the light source for passing light generated by the light source into the analysis cell, and a second wall portion associated with the light detector for passing light from the analysis cell to the light detector, wherein the first wall portion and the second wall portion are transparent or translucent to the light generated by the light source for passing light therethrough;a plunger configured to fit in the analysis cell and configured for movement along walls of the analysis cell for allowing entry of the liquid sample into the analysis cell and pushing the liquid sample out of the analysis cell;wherein at least one wiper is arranged on the plunger facing the walls of the ...

Method for quantitatively measuring the concentration of a compound of unknown concentration in protein samples

The present invention relates to methods of spectrophotometric determination of the presence of particular substances in a complex mixture of compounds. This invention relates to methods for determining the concentration of various components of complex biological samples including the determination of the concentration of polyoxyethylene containing compounds including polysorbate in protein containing samples as well as determining the ratio of drug to antibody ratios in antibody-drug conjugate solutions 1. A method for determining the concentration of a second compound in a solution comprising buffer and a first compound and a second compound comprising:a. collecting a set of optical density versus wavelength spectra at two or more path lengths of the buffer of a solution containing first compound only to produce a first buffer background spectra;b. collecting a set of optical density versus wavelength spectra at two or more path lengths for the solution containing first compound only;c. correcting the solution containing first compound spectra with the first buffer background spectra to produce a first compound background corrected spectra;d. selecting two or more data points at a first wavelength from the first compound background corrected spectra and performing linear regression on the data points to produce a first slope;e. selecting two or more data points at a second wavelength from the first compound background corrected spectra and performing linear regression on the data point to produce a second slope;f. calculating the ratio of the slopes at the first and second wavelengths for the first compound;g. collecting a set of optical density versus wavelength spectra at two or more path lengths of a buffer of a solution containing a known concentration of the second compound only to produce a second buffer background spectra;h. collecting a set of optical density versus wavelength spectra at two or more path lengths of a solution containing a known ...

Image forming apparatus and determination method

Provided is an image forming apparatus having a simplified sensor structure and configured to determine both the moisture content and paper type of paper. An image forming apparatus includes light-emitting units configured to illuminate paper—with a plurality of types of emission light having mutually different peak wavelengths, a light-receiving unit configured to receive reflected light, reflected from the paper, of the plurality of types of emission light, and a paper determination unit configured to determine the moisture content and the paper type of the paper, based on received-light intensities of the plurality of types of reflected light.

METHOD FOR PREPARING INTERMEDIATE BY REDUCED GLUTATHIONE-INDICATED AMINO ACID MAILLARD REACTION

A method for preparing an intermediate by a reduced glutathione-indicated amino acid Maillard reaction is provided. The method includes a two-stage reaction at an increased temperature. A reduced glutathione is added after different times of a low-temperature reaction, and a subsequent Maillard reaction is effectively inhibited on a basis wherein a substance is interacted with an intermediate degradation product to reduce a formation of colored substances. Comparing with a browning of Maillard products after a high-temperature stage, a reaction time with a best color inhibition effect is found to be the optimal preparation condition of the intermediate, and the intermediate is prepared in an aqueous medium at a low temperature under this optimal preparation condition. The method uses the water soluble reduced glutathione as a tracer to improve a tracing accuracy comparing to cysteine. 1. A method for preparing an intermediate by a reduced glutathione-indicated amino acid Maillard reaction , comprising the following steps:1) adding an amino acid and an aldose or ketose into water for a dissolution, and adjusting pH of a mixture to 6-8, wherein raw materials comprise by weight, 10 parts of amino acids, 10-40 parts of the aldose or the ketose and 200-1000 parts of the water;2) placing the mixture obtained in step 1) in water bath at a constant-temperature in 80-100° C. for a first-stage Maillard reaction, and taking out an equal volume of 5-8 samples in sequence from the mixture during this first-stage Maillard reaction at the 10th-180th minutes at an interval of 10-20 minutes and immediately placing the 5-8 samples in an ice bath for cooling to terminate a reaction to obtain first-stage Maillard reaction solutions;3) adding an equal amount of reduced glutathione into each sample of the 5-8 samples obtained in step 2) separately, re-adjusting the pH of the first-stage Maillard reaction solutions to 6-8 after uniform mixing, then transferring the first-stage Maillard ...

Sample Analysis Methods

The invention generally relates to methods for analyzing a heterogeneous sample. In certain aspects, the invention provides methods that involve illuminating a heterogeneous sample including a target analyte with polychromatic light, receiving luminous data of the heterogeneous sample and the target analyte is received to a detector without splitting the polychromatic light into individual wavelengths and generating spectral data therefrom. The analysis can be conducted without reacting the target analyte with chemical reagents. 1. A method for analyzing a heterogeneous sample , the method comprising:illuminating a heterogeneous sample comprising at least one target analyte with polychromatic light; andreceiving a luminous signal of the heterogeneous sample and the at least one target analyte to a detector without splitting the polychromatic light into individual wavelengths and generating spectral data therefrom, thereby analyzing the heterogeneous sample,wherein the method is conducted without reacting the at least one target analyte with a chemical reagent.2. The method of claim 1 , wherein the sample is at least one selected from the group consisting of a biological sample claim 1 , an environmental sample claim 1 , a food product sample claim 1 , and a beverage product sample.3. The method of claim 2 , wherein the biological sample is a human tissue or body fluid sample4. The method of claim 3 , wherein the body fluid sample is a blood sample.5. The method of claim 2 , wherein the body fluid sample is a urine sample.6. The method of claim 1 , further comprising analyzing the spectral data to obtain a concentration of the at least one target analyte.7. The method of claim 6 , wherein analyzing comprises comparing the spectral data to reference spectral data in which relative absorption of at least one reference analyte and concentration of the at least one reference analyte are known.8. The method of claim 1 , wherein the sample is a human tissue or body fluid ...

SAMPLE TEST METHOD, MICROFLUIDIC DEVICE, AND TEST DEVICE

A sample test method, microfluidic device, and test device efficiently and accurately compensates for interference of an interfering substance present in a sample using optical measurement without addition of a separate reagent for detecting the interfering substance. The sample test method includes: measuring an optical characteristic value of a target substance present in a sample; measuring an optical characteristic value of an interfering substance present in the sample; and determining a concentration of the target substance for which interference of the interfering substance is compensated for based on the optical characteristic value of the interfering substance. 1. A sample test method comprising:measuring an optical characteristic value of a target substance present in a sample;measuring an optical characteristic value of an interfering substance present in the sample; anddetermining a concentration of the target substance for which interference of the interfering substance is compensated for based on the optical characteristic value of the interfering substance,wherein the determining the concentration of the target substance for which interference of the interfering substance is compensated for comprises:determining the concentration of the target substance based on the optical characteristic value of the target substance, anddetermining the concentration of the interfering substance based on the optical characteristic value of the interfering substance, andcompensating the concentration of the target substance using the concentration of the interfering substance.2. The sample test method of claim 1 , wherein the compensating the optical characteristic value of the target substance comprises:applying a fluctuation coefficient to the concentration of the interfering substance to obtain an application result, and then subtracting or adding the application result from or to the concentration of the target substance.3. The sample test method of claim 1 , ...

METHOD FOR SIMULTANEOUSLY MEASURING ACTIVITY OF VARIOUS ENZYMES BY USING MULTI-WAVELENGTH ABSORPTION SINGLE CHANNEL

A method for simultaneously measuring the activities of multiple kinds of enzymes in single channel through concimitantly monitoring multiple wavelength absorbances is claimed; based on linear additivity of absorbances and the isoabsorbance wavelengths of chromogenic substrates and their chromogenic products, both the principles for the combination of chromogenic substrates required for simultaneously measuring the activities of multiple kinds of enzymes in single channel through concimitantly monitoring multiple wavelength absorbances and an approach for data processing to eliminate the interference of the overlapped absorbances are developed, kinetic analysis of reaction curves via numerical integration eliminates the interference of all substrates and products and estimates the maximal reaction rates of the enzymes to be measured, giving the linear ranges and the limits of quantification for simultaneously measuring the activities of multiple kinds of enzymes in single channel comparable to those by separate assays; the present invention is applicable for simultaneously measuring the activities of multiple kinds of enzymes in biological samples, simultaneously measuring multiple components by enzyme-labeled immunoassays, screening simultaneously of inhibitors against multiple targets, for the practice in clinical biochemical analyses, clinical immunoassays, health laboratory analyses, the discovery of inhibitors, and the basical researches which need the present invention. 1. A method for simultaneously measuring the activities of multiple kinds of enzymes in single channel through concomitantly monitoring multiple wavelength absorbances the method comprising:a. determining the combination of chromogenic substrates required for simultaneously measuring the activities of multiple kinds of enzymes:a1. selecting the combination of chromogenic substrates that meets the following criteria according to the specificity of the enzymes to be measured: the selected ...

Method and system for analysing a chemical composition of a target

According to an example aspect of the present invention, there is provided a method for analysing a chemical composition of a target, the method comprising placing an electrically tunable Fabry-Perot interferometer in a path of radiation emitted by a radiation source, and detecting the radiation, which has passed the Fabry-Perot interferometer and which has passed or was reflected by the target, by means of a detector, and wherein detection is made such that multiple pass bands are allowed to be detected simultaneously. 1. A method for analysing a chemical composition of a target , the method comprising:placing an electrically tunable Fabry-Perot interferometer a path of radiation emitted by a radiation source, anddetecting the radiation, which has passed the Fabry-Perot interferometer and which has passed or was reflected by the target, by means of a detector, and wherein detection is made such that multiple pass bands are allowed to be detected simultaneously.2. The method according to claim 1 , wherein a plurality of transmission peaks is scanned simultaneously or wherein at least two transmission peaks are measured simultaneously.3. The method according to claim 1 , wherein a combination of detected signals is analysed claim 1 , mixed signals are analysed or a sum of detected signals is analysed.4. The method according to claim 1 , wherein optical inputs with bandwidth of more than one single free spectral range of the Fabry-Perot interferometer are used.5. The method according to claim 1 , wherein band-limiting filters are not used in the method.6. The method according to claim 1 , wherein cut off values of a band-limiting filter are selected such that a detection range of a spectrometer is greater than a free spectral range or cut off values of the band-limiting filter are selected such that spectral components overlapping other transmission peaks propagate to the detector.7. The method according to claim 1 , wherein detection is made such that multiple pass ...

NOISE CANCELING DETECTOR

The present invention relates to an optical gas detector for detecting a gas absorbing light at a known wavelength, wherein the gas detector comprises two essentially identical, parallel membranes defining a volume between them containing the gas to be investigated, and a modulated first light source emitting light at said known wavelength into said volume at a chosen frequency, the detector is adapted to detect relative movements between said membranes and said movements having a frequency corresponding to the rate or a multiple of the rate of said pulsed light source, and wherein the said volume has at least one opening allowing the gas to unrestricted flow or diffuse into said volume. 1. Optical gas detector for detecting a gas absorbing light at a known wavelength , wherein the gas detector comprises two essentially identical , parallel membranes defining a volume between them containing the gas to be investigated , and a modulated light source emitting light at said known wavelength into said volume at a chosen modulation frequency , the detector is adapted to detect relative movements between said membranes caused by the light absorption in the gas and said movements having a frequency corresponding to the rate or a multiple of the rate of said modulated light source , and wherein the said volume has at least one opening allowing the gas to unrestricted flow or diffuse into said volume.2. Gas detector according to claim 1 , wherein the movement detection is provided by using means adapted to monitor the distance between said two membranes.3. Gas detector according to claim 2 , wherein said distance is monitored optically by transmitting monitoring light in a direction essentially perpendicular to said membranes claim 2 , said membranes being partly reflective and at least one of said membranes being partly transparent to said transmitted light claim 2 , thus providing a Fabry-Perot interferometer and by monitoring the transmitted or reflected intensity from ...

Concentration calculation system of optically active substance, manufacturing method of concentration calculation system of optically active substance, and computer readable medium

A concentration calculation system calculates a concentration of the optically active substance based on a formula. The formula includes a first function representing wavelength dependence of an optical rotation of a first optically-active substance, and a second function representing wavelength dependence of an optical rotation of a second optically-active substance. In the first function, concentration of the first optically-active substance has an unknown value, and an inherent value for defining a characteristic of optical rotatory dispersion of the first optically-active substance is a known value or an unknown value within a certain limited range. In the second function, an inherent value for defining a characteristic of optical rotatory dispersion of the second optically-active substance is an unknown value. The concentration of the first optically-active substance is calculated based on the formula and optical rotations of measurement target respectively corresponding to a plurality of wavelengths, by using a least-squares method.

METHOD FOR ESTIMATING A CARDIAC FREQUENCY AND ASSOCIATED DEVICE

The invention is a method for estimating a cardiac frequency via the detection of radiation backscattered or transmitted by a bodily zone. The part is illuminated, simultaneously or successively, by light radiation extending over a first spectral band and a second spectral band. A photodetector detects radiation emitted by the bodily zone under the effect of its illumination, in each of the spectral bands. A first detection function and a second detection function are formed from the radiation detected in each spectral band, respectively. The method allows the cardiac frequency to be determined via the determination of characteristic instants that are identified from the first detection function and the second detection function simultaneously. 2. The method according to claim 1 , wherein the second spectral band is different from the first spectral band.3. The method according to claim 1 , wherein step d) includes calculating a first derived function claim 1 , derived from the first detection function claim 1 , and a second derived function claim 1 , derived from the second detection function claim 1 , and identifying characteristic instants from each of the derived functions.4. The method according to claim 3 , wherein each derived function is obtained via a difference between the value of a detection function at two different instants.5. The method according to wherein:the first spectral band includes wavelengths comprised between 600 and 700 nm;the second spectral band includes wavelengths comprised between 750 nm and 1 μm.6. The method according to claim 1 , wherein the first spectral band extends between 600 nm and 700 nm claim 1 , whereas the second spectral band extends between 750 nm and 1 μm.7. The method according to claim 1 , wherein the detected radiation is radiation backscattered by the bodily zone under the effect of its illumination.8. A device for estimating a cardiac frequency of a living being claim 1 , including:a light source configured to emit ...

Photoacoustic Sensor

A photoacoustic sensor comprises an emitter for emitting electromagnetic radiation at a first wavelength and electromagnetic radiation at a second wavelength, wherein the first wavelength is for photoacoustically detecting particulate matter in a measurement cavity and the second wavelength is for photoacoustically detecting the particulate matter and at least one target gas in the measurement cavity. The photoacoustic sensor further comprises an acoustic transducer for transducing a first acoustic signal into a first sensor signal depending on an interaction of the electromagnetic radiation at the first wavelength and the particulate matter, and for transducing a second acoustic signal into a second sensor signal depending on an interaction of the electromagnetic radiation at the second wavelength with the particulate matter and the at least one target gas.

HYBRID PHONON-ENHANCED OPTICAL ABSORBERS AND EMITTERS

A semiconductor optical device is comprised of a phonon donating material structurally connected to an indirect bandgap material to improve absorption and emission of light in the indirect bandgap material. An excitation energy source provides excitation radiation to the semiconductor optical device to excite electrons in the semiconductor optical device. Phonons from the phonon donating material present in the indirect bandgap material provide a mechanism for increased rates of electron-hole generation and recombination, and electrical leads provide an electrical connection to the semiconductor optical device. 1. A semiconductor device comprising:an indirect bandgap material;a non-monolayer phonon donating material structurally connected to the indirect bandgap material and configured (i) to generate phonons, the phonons having a frequency that facilitates in the indirect bandgap material the absorption or emission of photons of a desired set of wavelengths and (ii) to deliver the phonons to the indirect bandgap material; andan electrical connection to the semiconductor device.2. A semiconductor device according to claim 1 , wherein the desired set of wavelengths is between 380 and 750 nanometers.3. A semiconductor device according to claim 1 , wherein the desired set of wavelengths is between 100 and 1300 nanometers.4. A semiconductor device according to claim 1 , wherein the desired set of wavelengths is shorter than 800 nanometers.5. A semiconductor device according to claim 1 , wherein the desired set of wavelengths is between 100 nanometers to 2 microns.6. A semiconductor device according to claim 1 , wherein the phonon donating material comprises a material with a hexagonal lattice.7. A semiconductor device according to claim 6 , wherein the phonon donating material with a hexagonal lattice comprises a transition metal dichalcogenide.8. A semiconductor device according to claim 1 , wherein the phonon donating material comprises a uniform bulk material.9. A ...

Photo-Acoustics Sensing Based Laser Vibrometer for the Measurement of Ambient Chemical Species

A laser vibrometer for measurement of ambient chemical species includes a laser that produces a beam that is split into a reference readout beam and a signal readout beam. A probe laser beam is tuned to an absorption feature of a molecular transition, and generates acoustic signals when incident on a gaseous species via the photo acoustic effect. The scattered acoustic signals are incident on a thin membrane that vibrates. The readout laser beam reflected from the vibrating membrane is mixed with the reference beam at the surface of a photo-EMF detector. Interferrometric fringes are generated at the surface of the photo-EMF detector. Electric current is generated in the photo-EMF detector when the fringes are in motion due to undulations in the signal readout beam imparted by the vibrating membrane. A highly sensitive photo-EMF detector is capable of detecting picoJoules or less laser energy generated by vibrating processes. 1. A laser vibrometer capable of detecting and displaying pressure waves from acoustic signals comprising:a first laser configured to produce a first beam of monochromatic light having a wavelength that corresponds to an absorption feature of a chemical species that is to be detected;a second laser configured to produce a second beam of monochromatic light;a beam splitter configured to split the second beam of monochromatic light into a reference beam and a sensing beam, the reference beam being directed to a photosensor;a pressure-sensing diaphragm which when impacted by pressure waves caused by the first beam of light responsively vibrates;a photo-EMF sensor;wherein the sensing beam is directed against the pressure sensing diaphragm; andwherein the sensing beam is directed to the photo-EMF sensor from the pressure sensing diaphragm, which photo-EMF sensor outputs a signal corresponding to the displacement of the diaphragm caused by the incident pressure wave.2. The laser vibrometer of claim 1 , wherein;the first laser produces a beam of light ...

Sample cell

An optical cell comprises first and second opposed reflecting elements, an entrance aperture in the first reflecting element and an exit aperture in the second reflecting element, wherein the entrance and exit apertures are configured such that, in operation, light introduced into the cell via the entrance aperture is reflected at least once by the second reflecting element and at least once by the first reflecting element before leaving the cell via the exit aperture.

Gas detector

A gas detector includes: an infrared camera that images a gas; and a controller including at least an electronic component, wherein the controller determines a temperature range of the infrared camera in which the gas can be imaged, and detects the gas from moving infrared images taken for a predetermined period of time in the temperature range determined.

FREQUENCY DOMAIN-BASED MULTI-WAVELENGTH BIO-SIGNAL ANALYZING APPARATUS AND METHOD THEREOF

Provided is a frequency domain (FD)-based multi-wavelength bio-signal analyzing apparatus including: four or more light sources configured to irradiate frequency-modulated light at four or more different discrete wavelengths; at least one light detector configured to detect an output light reflected and introduced from a subject; and a processing circuit connected to the four or more light sources and the at least one light detector and configured to calculate a scattering coefficient and an absorption coefficient at each discrete wavelength based on an output light detected by the at least one light detector and calculate a concentration of a chromophore present in the subject based on the scattering coefficient and the absorption coefficient at each discrete wavelength. Herein, the processing circuit drives at least two of the four or more light sources based on the chromophore present in the subject. 1. A frequency domain (FD)-based multi-wavelength bio-signal analyzing apparatus , comprising:four or more light sources configured to irradiate frequency-modulated light at four or more different discrete wavelengths;at least one light detector configured to detect an output light reflected and introduced from a subject; anda processing circuit connected to the four or more light sources and the at least one light detector and configured to calculate a scattering coefficient and an absorption coefficient at each discrete wavelength based on an output light detected by the at least one light detector and calculate a concentration of a chromophore present in the subject based on the scattering coefficient and the absorption coefficient at each discrete wavelength,wherein the processing circuit drives at least two of the four or more light sources based on the chromophore present in the subject.2. The FD-based multi-wavelength bio-signal analyzing apparatus of claim 1 ,wherein the processing circuit determines the number and kinds of light sources to be driven from ...

Optical Detection of Tracer Gases in a Gas Discharge Cell Having Unexposed Electrodes

Tracer gas sensing device comprising a gas discharge cell having cell walls defining a discharge volume and a tracer gas inlet into the discharge volume, an optical spectrometer arrangement having a radiation source on a first side of the discharge cell for emitting radiation into the discharge cell and a radiation detector on a second side of the discharge cell opposite to the first side for detecting radiation which was emitted by the radiation source through the discharge volume, and electrodes on opposing sides of the discharge cell for generating a plasma within the discharge cell, said electrodes being unexposed plasma electrodes. The discharge cell may be a dielectric barrier discharge cell and the electrodes may be powered by an AC power source. 1. A tracer gas sensing device comprising:a gas discharge cell havingcell walls defining a discharge volume anda tracer gas inlet into the discharge volume;an optical spectrometer arrangement havinga radiation source on a first side of the gas discharge cell for emitting light into the gas discharge cell anda radiation detector on a second side of the gas discharge cell opposite to the first side for detecting radiation that is emitted by the radiation source through the discharge volume; andelectrodes on opposing sides of the gas discharge cell for generating a plasma within the gas discharge cell, said electrodes being unexposed plasma electrodes.2. The tracer gas sensing device according to claim 1 , wherein an electrically insulating material is provided between each electrode and the discharge volume.3. The tracer gas sensing device according to claim 2 , wherein each electrode is covered by said electrically insulating material.4. The tracer gas sensing device according to claim 2 , wherein the electrically insulating material is a portion of a cell wall of the gas discharge cell.5. The tracer gas sensing device according to claim 1 , wherein the gas discharge cell is a dielectric barrier discharge cell.6. The ...

Method for determining the concentration of a substance in a deformable container

The invention relates to a non-destructive and non-invasive method for determining the concentration or other parameters of constituent substances in fluids, which method is capable of minimizing the optical interfering influences, which are unknown but constant during the individual measurement, of the vessel wall on the measurement result or the evaluation, in that measurements are carried out with different through-radiation path lengths and quotient calculations eliminate the influences of the vessel wall. Wide-area illumination and detection ensure that non-linearities occurring during said measurements do not interfere with the accuracies of the determination.

System and method for monitoring a fire suppression blend

Disclosed herein is a system and method for monitoring a gaseous fire suppression blend. The system includes a sensor array having a plurality of sensors disposed in a protected space, wherein the sensor array can detect and quantify more than one component of the gaseous fire suppression blend.

Single molecule spectroscopy using photothermal tuning of optical microcavities

Methods and apparatuses for single particle and single molecule spectroscopy are provided. A method comprises exposing the surface of an optical microcavity characterized by at least one resonance frequency to a sample such that a single particle or a single molecule from the sample adsorbs onto the surface of the microcavity; evanescently coupling a probe laser beam into the microcavity, wherein the wavelength of the probe laser beam substantially matches the at least one resonance frequency; illuminating the surface of the microcavity with a free space pump light beam such that the focal spot of the free space pump light beam substantially overlaps with the single particle or the single molecule; and detecting light from the probe laser beam, wherein the wavelength of the free space pump light beam is that which generates sufficient heat via energy absorbed by the single particle or the single molecule from the free space pump light beam to induce a shift in the at least one resonance frequency, thereby providing a change in an optical characteristic of the detected light from the probe laser beam.

Measurement apparatus for measuring the concentration of a gaseous substance

The invention relates to a measurement apparatus for measuring the concentration of a gaseous substance. The apparatus comprises a light source, a light sensor, and a housing comprising at least one first housing member having a low thermal conductivity. A light path is formed from said light source to said light sensor, wherein the light path passes through a measurement region within said housing. The light source is configured to emit light with a spectral distribution such that said light is absorbed by said gaseous substance. Said light sensor is configured to receive the light emitted by the light source after it has passed through the measurement region. The first housing member comprises a thermal shielding region facing said measurement region on its one side and said light sensor on its other side, and is configured to permit the passage of light.

Real-time trace gas sensor using a multi-mode diode laser and multiple line integrated cavity enhanced absorption spectroscopy

A highly sensitive trace gas sensor based on a Fabry-Perot semiconductor laser and cavity enhanced absorption spectroscopy is designed to be capable of measuring sub-ppb concentrations of trace gases in real time. The broad frequency range of the multi-mode Fabry-Perot semiconductor laser spans a large number of absorption lines of the species of interest enabling multiple line integrated absorption spectroscopy which improves the sensitivity of detection. Additionally, the broad wavelength range of the laser excites a large number of cavity modes simultaneously, thereby reducing the sensor's susceptibility to vibration and thermal fluctuations making it suitable for field based monitoring applications. Using a high finesse optical cavity also enhances the sensitivity of the sensor by providing large path lengths, on the order of kilometers, in a small volume. Relatively high laser power is used to compensate for the low coupling efficiency of a broad linewidth laser to the optical cavity.

CURCUMIN-CONTAINING MEDICINAL PREPARATION AND METHOD FOR EVALUATING ABSORPTION OR ELUTION CHARACTERISTICS THEREOF

An object of the present invention is to provide a curcumin-containing preparation that enables efficient curcumin ingestion. The object is achieved by a curcumin-containing preparation comprising amorphous curcumin and being substantially free of crystalline curcumin, wherein, in an infrared absorption spectrum with curve fitting by a Voigt function, a ratio (Cp/Ap) is 0.25 or less, the ratio (Cp/Ap) being a ratio of peak intensity Cp having the maximum in the range of 1508.00 to 1513.00 cmto peak intensity Ap having the maximum in the range of 1513.50 to 1517.00 cm. 1. A curcumin-containing preparation comprising amorphous curcumin and being substantially free of crystalline curcumin , wherein , in an infrared absorption spectrum with curve fitting by a Voigt function , a ratio (Cp/Ap) is 0.25 or less , the ratio (Cp/Ap) being a ratio of peak intensity Cp having the maximum in the range of 1508.00 to 1513.00 cmto peak intensity Ap having the maximum in the range of 1513.50 to 1517.00 cm.2. The preparation according to claim 1 , wherein the content of curcumin is 10 mass % or more based on the entire preparation.3. A method for predicting curcumin-dissolubility of a curcumin-containing preparation into body fluid claim 1 , the method comprising:(1) a stage of performing infrared spectroscopic analysis of a curcumin-containing preparation;(2) a stage of performing curve fitting with respect to an infrared absorption spectrum obtained in stage (1) using a Voigt function;{'sup': −1', '−1, '(3) in the curve-fitted infrared absorption spectrum obtained in stage (2), a stage of calculating a ratio (Cp/Ap) of peak intensity Cp having the maximum in the range of 1508.00 to 1513.00 cmto peak intensity Ap having the maximum in the range of 1513.50 to 1517.00 cm; and'}(4) a stage of assuming high curcumin-dissolubility into body fluid when the ratio (Cp/Ap) is small.4. A method for predicting curcumin-absorbability of a curcumin-containing preparation into a body claim 1 ,the ...

SLOPE SPECTROSCOPY STANDARDS

The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements. 1. A method of making a slope spectroscopy standard for a compound comprising:selecting a compound;determining the slope at a predetermined concentration of the compound;determining a concentration of a standard which corresponds to the compound slope by using variable path length spectroscopy wherein the compound and the standard are different compounds and wherein the compound and the standard have absorbance spectra that share a common absorbance wavelength; andmaking a standard of an appropriate concentration which provides a slope measurement that corresponds to that of the compound.2. The method of wherein the standard is in an aqueous solution.3. The method of wherein the standard has a slope measurement of from about 0.01 to 500.4. The method of wherein the standard has a slope measurement of from about 1 to 500.5. The method of wherein the standard is a methylxanthine.6. The method of claim 5 , wherein the methylxanthine is selected from the group consisting of caffeine claim 5 , aminophylline claim 5 ,IBMX claim 5 , paraxanthine claim 5 , pentoxifylline claim 5 , theobromine claim 5 , and theophylline7. The method of wherein the methylxanthine is caffeine.8. The method of wherein the standard is selected from the group consisting of NaCl claim 1 , KHP claim 1 , KCl and KCrO.9. The slope spectroscopy standard of wherein the standard has an uncertainty value of from about 0.1% to about 5%.10. A method of making a slope spectroscopy standard for a combination of a particular ratio of first compound to second compound in a combination of compounds comprising:determining the ratio of the first compound to the second compound in a combination of the compoundsdetermining a concentration of first substance which absorbs ...

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations inc multicomponent liquid systems

Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

METHOD AND APPARATUS FOR ANALYZING GASEOUS SAMPLES

A measuring apparatus for measuring a spectrum of a gaseous sample includes

Non-dispersive infrared sensor

Disclosed is a sensor and method for detecting one or more gasses in a sample. The sensor includes two sample tube sections, which allow for a larger sample, and correspondingly, more accurate measurement. Having two sample tube sections increases the total length of the sample path. However, placing the sample tube sections in parallel allows for the performance of the sensor to be enhanced, but the footprint of the sensor to remain unchanged. Light pipe material may be used to transport the light between sample tube sections. Further, light pipe material may be used to move the IR lamp away from the first filter tube section, reducing problems in the thermopile by dissipating heat from the IR lamp away from the sample tube section.

Methods for determining transition metal compound concentrations inc multicomponent liquid systems

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems and for improving methods of preparing the multicomponent catalyst system.

methods for determining concentrations of transition metal compound in multi-component liquid systems

São descritos métodos para determinar a concentração de compostos de metais de transição em uma solução contendo mais de um composto de metal de transição. São divulgados sistemas de reator de polimerização fornecendo monitoramento e controle em tempo real das concentrações dos componentes de metal de transição de um sistema de catalisador de múltiplos componentes, bem como métodos para operar esses sistemas de reator de polimerização e para melhorar os métodos de preparação do sistema de catalisador de múltiplos componentes. Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems are provided providing real-time monitoring and control of the concentrations of the transition metal components of a multi-component catalyst system, as well as methods for operating these polymerization reactor systems and for improving the methods of preparing the polymerization reactor. multi-component catalyst system.

用于确定多组分液体系统中的过渡金属化合物浓度的方法

描述了用于确定含有多于一种过渡金属化合物的溶液中的过渡金属化合物的浓度的方法。公开了提供对多组分催化剂系统的过渡金属组分的浓度的实时监测和控制的聚合反应器系统，以及用于操作此类聚合反应器系统和用于改进制备所述多组分催化剂系统的方法的方法。

Methods for determining transition metal compound concentrations in multicomponent liquid systems

确定多组分液体系统中过渡金属化合物浓度的方法

描述了用于同时确定包含两种或更多种过渡金属化合物的溶液中的过渡金属化合物的浓度的方法。公开了提供多组分催化剂体系的过渡金属组分的浓度的实时监测和控制的聚合反应器系统，以及用于操作这样的聚合反应器系统的方法和用于改进制备所述多组分催化剂体系的方法的方法。

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Method of determining concentration of a transition metal compound in a multicomponent liquid system

FIELD: measurement technology; chemistry. SUBSTANCE: invention relates to a method of determining concentrations of transition metal compounds in solutions containing more than one transition metal compound. Method includes: (I) contacting a catalyst system comprising a first transition metal compound, a second transition metal compound, an activator and an optional cocatalyst, with an olefin monomer and an optional olefin comonomer in a reactor within a polymerisation reactor system under polymerisation reaction conditions to produce an olefin polymer; (II) determining a first concentration of a first transition metal compound and a second concentration of a second transition metal compound in the solution, containing a first transition metal compound and a second transition metal compound, wherein the first concentration and the second concentration are determined at steps including: (i) obtaining a first reference absorption profile (F 1 ) of a first transition metal compound in a first reference solution at a first known concentration and a second reference absorption profile (F 2 ) of a second transition metal compound in a second reference solution at a second known concentration; (ii) feeding a sample of the solution into a sample chamber; (iii) irradiating the sample in the chamber with a light beam at a wavelength in the UV-visible spectrum; (iv) generating an absorption profile of the sample and calculating a curve having formula β 1 F 1 + β 2 F 2 , to match the absorption profile of the sample to a least square regression value (R 2 ) of at least 0.9; where: β 1 is the first weight coefficient; F 1 is the first reference absorption profile of the first transition metal compound in the first reference solution at a first known concentration; β 2 is the second weight coefficient; and F 2 is a second reference absorption profile of a second transition metal compound in a second reference solution at a second known concentration; and (v) multiplying the first ...

Methods for Determining Transition Metal Compound Concentrations in Multicomponent Liquid Systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations in multicomponent liquid systems

Methods for simultaneously determining the concentrations of transition metal compounds in solutions containing two or more transition metal compounds are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems, and for improving methods of preparing the multicomponent catalyst system.

Methods for determining transition metal compound concentrations inc multicomponent liquid systems

Methods for determining the concentration of transition metal compounds in a solution containing more than one transition metal compound are described. Polymerization reactor systems providing real-time monitoring and control of the concentrations of the transition metal components of a multicomponent catalyst system are disclosed, as well as methods for operating such polymerization reactor systems and for improving methods of preparing the multicomponent catalyst system.

一种快速检测多种致病菌的方法

本发明提供了一种快速检测多种致病菌的方法，其特征在于首先是制备双功能复合纳米球。然后，分别将不同尺寸的量子点和复合功能纳米球与可以特异性识别目标菌的单克隆抗体连接，得到几种能够与目标菌表面抗原进行抗原-抗体反应的免疫量子点探针和免疫复合纳米球探针。这种复合结构的纳米球既可以作为免疫识别分离多种致病菌的载体，又可以作为免疫量子点探针的信号增强子，实现检测信号的二次放大，通过在相应波长下检测其光学强度就可以实现多种目标微生物的检测。此方法通过磁性纳米颗粒免疫分离和量子点“双重标签”的信号扩增效应，能够大大缩短检测时间（≤2小时），提高灵敏度，并实现多种致病菌的同时检出。适合于食品、环境样品的现场快速检测及基层普及应用。

비침습적 혈당치 추정을 위한 휴대용 장치 및 방법

본 발명은 혈당치를 측정하기 위한 측정 모듈(4)과, 혈당치를 측정하기 위한 공정의 제 1 부분으로부터의 데이터를 처리하기 위한 제 1 컴퓨터 모듈(5)과, 제 1 통신 모듈(6)과, 제 1 데이터 저장 모듈(7) 및 푸시버튼(8)을 갖는 측정 유닛(2)을 포함하는 장치(1)에 관한 것이다. 장치는 또한 제 2 및 제 3 통신 모듈(17, 20)과, 혈당치를 측정하기 위한 공정의 제 2 부분으로부터의 데이터를 처리하도록 구성된 제 2 컴퓨터 모듈(18)과, 인터페이스 모듈(19) 및 제 2 데이터 저장 모듈(22)을 갖는 개인 모니터링 유닛(3)을 포함한다. 비침습적 혈당치 추정 방법이 또한 개시된다.

Non-invasive, miniature, breath monitoring apparatus

A rugged, miniature, spectroscopic gas analyzer apparatus for rapid, non-invasive, multi-component breath monitoring and analysis and subsequent determination of Q or other medical diagnostic applications. The system is comprised of one or more IR emitters focussed by optical elements through a low volume sample cell receiving a sample input of a patient's breath for analysis. The patient either at rest or during exercise, inhales C 2 H 2 —SF 6 mixtures (balance of oxygen and nitrogen) which is subsequently monitored upon exhalation for CO 2 , H 2 O, C 2 H 2 , and SF 6 which can be employed to determine Q directly and accurately. Measurements are performed in real-time or via post-processing of stored original data. Due to its small size, ruggedness, and low power consumption, the monitor can conveniently be employed in the field or data can also be retrieved remotely using telemetry. The miniature analyzer operates on the principle of infrared absorption spectroscopy and allows very precise concentration measurements of the analytes of interest, without any bias or interference from other matrix components.

用于分子物质光学传感的光谱设备、系统和方法

本发明公开了一种用于测量气体、液体或固体样品中一种或多种目标分子物质的浓度的光谱设备、系统和方法，其中所述设备可以是便携式的，可以是商业制造的，和/或可以适于现有系统和/或与新系统集成以为此类系统提供光学气体传感。所公开的设备、系统和方法在监测例如某种气体物质的纯度中特别有用，包括确定气体混合物是否包含高于设定浓度极限的某些气体物质。

Surface Enhanced Raman Scattering Substrate, Device for Detecting Molecule and the Fabrication Method thereof

본 발명은 표면증강 라만산란 기판에 관한 것으로, 본 발명에 따른 표면증강 라만산란 기판은 공중 부유형 제1금속 나노입자, 상기 제1금속 나노입자를 지지하는 지지부재, 상기 제1금속 나노입자와 나노갭을 형성하며 상기 제1금속 나노입자의 둘레를 감싸는 제2금속 막을 포함하며, 상기 제1금속 나노입자의 제1금속 및 제2금속 막의 제2금속은 각각 표면 플라즈몬이 발생하는 금속일 수 있다. The present invention relates to a surface enhanced Raman scattering substrate, and a surface enhanced Raman scattering substrate according to the present invention is a surface enhanced Raman scattering substrate comprising a first metal nanoparticle of a hollow particle type, a support member for supporting the first metal nanoparticle, Wherein the first metal of the first metal nanoparticles and the second metal of the second metal nanoparticle are metal atoms that generate surface plasmons, respectively, have.

Gas detector using infrared

Autofocus immunochromatography sensitive detection system

The present invention relates to an autofocus immunochromatography high-sensitivity detection system, which comprises: an immune sensor kit including a membrane on which a test line composed of a reflective film micropattern is formed; a first laser device for irradiating a detection beam of a first wavelength to a reactive material in a groove between the reflective film micropatterns of the test line; a second laser device irradiating a focusing beam of a second wavelength onto the reflection film micropattern of the test line; a control unit controlling focusing of the detection beam irradiated onto the reaction material in the first laser device using a focusing beam reflected from the reflection film micropattern; and a light receiving element for detecting the fluorescence intensity of the reaction material reacted by the detection beam irradiated onto the reaction material.

Device for automatically evaluating a plurality of probe ingredients by means of chemical sensors

Device for the automatic evaluation of a plurality of test sample components, in particular within the field of water and sewage water analysis, comprising at least one chemical sensor into which the test sample component(s) is/are placed, and comprising a measuring device to determine the measurable variables which are characteristic for the test sample component(s), characterized in that each sensor is provided with a coding region for information regarding the measurable variable to be determined, and in that a reading device, for the evaluation of the coding region, and a monitoring device, which is connected to the reading device and the measuring device, are provided, wherein the monitoring device adapts the measuring device to the measurable variable to be determined on the basis of the reading supplied by the reading device.

Method for determining the concentration of a substance in a deformable container

The invention relates to a non-destructive and non-invasive method for determining the concentration or other parameters of constituent substances in fluids, which method is capable of minimizing the optical interfering influences, which are unknown but constant during the individual measurement, of the vessel wall on the measurement result or the evaluation, in that measurements are carried out with different through-radiation path lengths and quotient calculations eliminate the influences of the vessel wall. Wide-area illumination and detection ensure that non-linearities occurring during said measurements do not interfere with the accuracies of the determination.

Multipass sample cuvette

FIELD: monitoring and measuring equipment.SUBSTANCE: invention relates to a sample cuvette, for example a sample cuvette for use in gas analysis based on laser absorption spectroscopy. Disclosed detection system comprises: at least one laser configured to output at least one laser radiation beam for absorption by one or more different connections; sample cuvette intended for containing a certain volume of gas sample; at least one guiding device configured to direct said at least one laser radiation beam into a sample cuvette; and a detector device for detecting output radiation from the cuvette. Sample tray includes: first and second opposite reflecting elements (80, 82); inlet (84) in the first reflecting element (80) and outlet (86) in the second reflecting element (82). At that, inlet and outlet holes are made so that during operation radiation, introduced into the cuvette through inlet (84) is reflected at least once by the second reflecting element (82) and at least once by the first reflecting element (80) before exiting from the cuvette through outlet (86), and wherein during operation said radiation is reflected from first reflecting element in plurality of first reflection points and reflected from second reflecting element in plurality of second reflection points (90), and a control device for obtaining relative rotational movement of the second reflecting element (82) and the first reflecting element (80) with location of outlet (86) in the selected point from said plurality of second reflection points (90), wherein the path through which radiation between the inlet and outlet holes follows determines the path length. Control device is configured to cause relative movement of outlet opening (86) and second reflection points (90) by predetermined distances, corresponding to spacing of second reflection points (90), and is additionally configured to change in stepwise manner the position of outlet opening (86) from one of second reflection points (90) to ...

Measurement system and method for measuring parameters in a body tissue

A measurement system and method for measuring at least one parameter in a body tissue comprise at least one measurement device to be applied to the body, an optical unit for emitting light waves, wherein at least one wavelength of the light waves lies in the region of the absorption of a body parameter, at least one light guide between the optical unit and the measurement device in order to transmit light waves, and an evaluation unit for evaluating measurement waves. Light waves emitted by the optical unit can be beamed into an optical measurement volume in the body tissue by means of the measurement device, and measurement waves received by the measurement device from the measurement volume can be transmitted from the body tissue to the evaluation unit. The evaluation unit comprises a transformation algorithm, which transforms pulsatility of a body parameter measured in the measurement volume into a parameter of the pressure in the body tissue, wherein the body parameter is measured by determining the absorption of the light waves. DRAWING: No translation necessary.

Multi-pass sample cell

【課題】レーザ吸収分光法に基づくガス分析における使用のためのサンプルセルを提供する。【解決手段】光学セルは、第１及び第２の対向した反射要素（８０，８２）と、第１の反射要素内の入射口（８４）及び第２の反射要素内の射出口（８６）とを含み、ここで入射口及び射出口は、作動時に、入射口を経由して導入される光が、射出口を経由してこのセルから離れる前に第２の反射要素によって少なくとも１回及び第１の反射要素によって少なくとも１回反射されるように構成されている。この光学セルは、セル内の光路長を修正すべく第１及び第２の反射要素の相対的な動き、例えば、並進又は回転を得るための調整装置を更に含んでいてもよい。【選択図】図４

Method to measure concentration of uranium in aqueous solution by method of spectrophotometry

FIELD: measurement equipment. SUBSTANCE: invention relates to the method to measure concentration of uranium in an aqueous solution, including the following subsequent stages: a) electrochemical restoration of uranium to valency IV present in an aqueous solution with valency above IV, besides, this restoration is carried out at pH<2 by sending the electric current into the solution; b) measurement of optical density of the solution produced upon completion of the stage a), at the chosen wave length between 640 and 660 nm, and preferably - 652 nm; and c) determination of uranium concentration in the aqueous solution by means of production of the uranium concentration with valency (IV), present in the aqueous solution produced upon completion of the stage a), from the result of optical density measurement produced at the stage b). EFFECT: invention makes it possible to reduce sensitivity to presence of ions in a solution, does not require to use additional chemical reagents, there is an option of automation. 10 cl, 6 dwg, 3 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 21/31 (13) 2 573 445 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013117129/28, 13.09.2011 (24) Дата начала отсчета срока действия патента: 13.09.2011 (72) Автор(ы): СЕЛЬЕ Магали (FR), НАРДУ Паскаль (FR) (73) Патентообладатель(и): АРЕВА НС (FR) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.10.2014 Бюл. № 30 R U 16.09.2010 FR 1057407 (45) Опубликовано: 20.01.2016 Бюл. № 2 (86) Заявка PCT: C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 16.04.2013 EP 2011/065806 (13.09.2011) (87) Публикация заявки PCT: 2 5 7 3 4 4 5 WO 2012/034989 (22.03.2012) R U 2 5 7 3 4 4 5 (56) Список документов, цитированных в отчете о поиске: US 4080273 A, 21.03.1978. US 3878060 A, 15.04.1975. US 4939119 A, 03.07.1990. US 2008/ 0079942 A1, 03.04.2008. US 2010/0072059 A1, 25.03.2010. US 4534940 A, ...

Patent RU2018139645A3

`”ВУ“” 2018139645” АЗ Дата публикации: 23.06.2020 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2018139645/28(065840) 18.04.2017 РСТ/СВ2017/051078 18.04.2017 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 15/133,517 20.04.2016 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) МНОГОХОДОВАЯ КЮВЕТА ДЛЯ ОБРАЗЦА Заявитель: КЭСКЕЙД ТЕКНОЛОДЖИЗ ХОЛДИНГС ЛИМИТЕД, СВ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) СОЛМ 21/03 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) СОТ 21/00, 21/01, 21/03, 21/31 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): ВУРАТЕМТЗ, ОУУРТ, Е-Габгагу, ЕАРАТТ$, ЕВЗСО, Езрасепе, Соозе, боозе Раепб, /]- Р]а(Раё, КТРКЪУ, Гех15Мех15, РАТЕМТЗСОРЕ, Ра еагсв, Оцез{е]-Оти, КОРТО, ИЗРТО 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ПОИСКА Кате- Наименование документа с ...

METHOD AND DEVICE FOR CONTROLLING THE PRODUCTION QUALITY OF A MOVING RAIL

Mercury vapor trace detection using pre-excitation cavity ring down spectroscopy

本发明提供了装置和技术，其可以包括使用具有第一范围的波长的光能将光学共振腔中的分析物气体光激发，所述第一范围的波长包括被规定为提供所述分析物气体中待探测物种的亚稳激发态的波长。这种光激发可以被称为“预激发”。可以将具有第二范围的波长的光能耦合至所述光学共振腔，所述第二范围的波长包括被规定为利用所述分析物气体中所述待探测物种的亚稳激发态吸收的波长，并且将所述具有第二范围的波长的光能外耦合至检测器。可以监测衰减速率或衰减持续时间(例如，“衰荡”特性)中的一个或多个，以确定所述分析物气体中所述物种的存在或量。这种预激发和探测可以被称为预激发腔衰荡光谱法(PE-CRDS)，如用于汞的痕量检测。

Neutrophil gelatinase-associated lipocalin reagent box for detecting content

一种中性粒细胞明胶酶相关脂质运载蛋白含量检测试剂盒，该试剂盒由试剂Ⅰ和试剂Ⅱ组成，试剂Ⅰ包括缓冲剂；试剂Ⅱ的组分包括包被中性粒细胞明胶酶相关脂质运载蛋白抗体的胶乳颗粒，所述试剂Ⅰ中还包括变性剂。蛋白质的聚集体状态通过添加变性剂使之产生某种程度的变性，暴露出物理和(或)化学结合部位，然后巯基解离剂断裂化学结合部位的化学结合作用，表面活性剂则分散物理结合部位的物理结合作用，使聚集体解聚；因此，合适的变性剂、巯基解离剂、表面活性剂的种类和浓度选择就尤为重要，既要解聚聚集体，又不能干扰随后的免疫学检测；而本发明的变性剂、巯基解离剂、表面活性剂的种类和浓度通过特定的筛选和确定，正好解决了上述技术问题。

Culture medium

본 발명의 일 실시예에 따른 배양기는 본체 및 도어로 그 외형을 이룬다. 그리고, 본체 및 도어 내부에는 배양용기, 제1감지체, 제2감지체, 광원, 제1감지유닛, 제2감지유닛 및 제어부를 포함한다. 제어부는 제1감지유닛 및 제2감지유닛으로부터 계측되는 각각의 빛의강도를 기초로 배양용기에 수용된 액체의 pH농도 및 용존산소량을 도출한다. An incubator according to an embodiment of the present invention has a main body and a door. In addition, the main body and the inside of the door include a culture vessel, a first sensing body, a second sensing body, a light source, a first sensing unit, a second sensing unit, and a control unit. The control unit derives the pH concentration and dissolved oxygen content of the liquid contained in the culture vessel based on the light intensity measured by the first and second detection units.

Multichannel gas analyzer and method of use

An improved gas analyzer system and method for detecting and displaying the constituent gases of a respiratory gas stream, the system comprising an optical bench (109) comprising a gas pathway for the flow of a gas stream, a flow shaping inlet, three infrared detection channel assemblies for measuring the partial pressures of constituent gases, and measuring sensitivity changes in the detectors of the three infrared detection channel assemblies, a pressure sensor for measuring the pressure within the gas pathway, a temperature sensor for measuring the temperature within the optical bench, a flow rate sensor for measuring the gas flow rate through the gas pathway; analog processing circuitry (124) for processing the detected partial gas pressures, sensitivity changes, the measured values for pressure, temperature, and flow rate, and display processing circuitry (128).

Method for distinguishing respiratory events in a gas analyzer

A gas analyzer system and method for detecting and displaying information of gases in a respiratory gas stream, comprising an optical bench including a gas pathway for the flow of a gas stream through the optical bench, a flow shaping inlet at the entrance to the optical bench's gas pathway, two infrared detection channel assemblies for measuring the partial pressures of the gases in the respiratory gas stream, a pressure sensor for measuring the pressure within the gas pathway, a temperature sensor for measuring the temperature within the optical bench, and a flow rate sensor for measuring the gas flow rate through the gas pathway, circuitry for processing the detected partial pressures of the gases and the measured values for pressure, temperature, and flow rate, and for providing output signals indicative of processed measured values, the detected partial pressures of the gasses, and characterization information with respect to the optical bench components; analog input circuitry for processing the signals output from the optical bench for input to analog processing circuitry; analog processing circuitry for processing and correcting at least the detected partial pressures of the gases signals for collision broadening, temperature, pressure in the gas pathway, barometric pressure, cross-correction, and characterization of the optical bench components, and providing output signals indicative of the corrected partial pressures of the gases to display processing circuitry; display processing circuitry for processing the signals for display of at least the corrected partial pressure of one gas on a cathode ray tube.

A kind of total nitrogen in-line analyzer and its detection method

本发明涉及一种总氮在线分析仪和其检测方法，包括通过管路相连接的用于提供采样动力的蠕动泵、计量模块、多通阀、高温高压阀、检测模块、高温消解模块。蠕动泵通过管路与计量模块相通，计量模块的上端与蠕动泵相通，下端与多通阀相通，多通阀通过不同的管路与计量模块的公共管路、高温消解模块、检测模块和试剂仓中的水样、量标、零标、废液和至少一个试剂管路相通，高温消解模块的上下两端分别设置有高温高压阀，下端与多通阀相通，上端与空气相通。本发明整体小巧紧凑、结构简单，光路设计可以排除有机物的干扰，水样和试剂用量很少，废液处理成本低，试剂保质期长，测量精准，检测环境稳定。

Image analysis apparatus, imaging system, surgery support system, and image analysis program

Pulsed ultrasound modulated optical tomography using lock-in camera

A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate a plurality of different interference light patterns. Spatial components of each of the different interference light patterns are simultaneously detected and stored in bins.

Method and device for detecting trace amounts of many gases

The photoacoustic device for measuring the amount of at least one gas comprises: a Helmholtz resonant cell (14, 114, 214, 314A, 314B), consisting of at least two tubes closed at their ends and connected together, close to each of their ends, by capillary tubes having a diameter smaller than the diameter of the parallel tubes, and a means (15, 55) for introducing a gas into said cell. This device further includes: at least two physically separate radiant laser energy sources (11A, 11B, 215) each designed to deliver excitation energy to the gas contained in the cell, a different emission wavelength corresponding to a local maximum absorption wavelength for said gas, each said radiant energy source being positioned facing a window (52) closing off one end of the tube; a modulation means (17), which modulates the excitation energy delivered by each of the laser energy sources with a modulation frequency corresponding to the acoustic resonant frequency of the resonant cell; and at least one acoustic-electric transducer (20, 21) placed on one of the tubes so as to detect the acoustic signals produced in this tube and deliver an electrical signal representative of the concentration of the gas in the cell.

METHOD FOR MEASURING URANIUM CONCENTRATION IN AQUEOUS SOLUTION BY SPECTROPHOTOMETRY

1. Способ измерения концентрации урана в водном растворе, включающий в себя следующие последовательные этапы:a) электрохимическое восстановление до валентности IV урана, присутствующего в водном растворе с валентностью выше IV, причем это восстановление осуществляют при pH<2 путем пропускания электрического тока в раствор;b) измерение оптической плотности раствора, полученного по завершении этапа a), на выбранной длине волны между 640 и 660 нм; иc) определение концентрации урана в водном растворе путем выведения концентрации урана валентности (IV), присутствующего в водном растворе, полученном по завершении этапа a), из результата измерения оптической плотности, полученного на этапе b).2. Способ по п. 1, в котором электрохимическое восстановление урана, присутствующего в водном растворе, осуществляют, проводя следующие последовательные этапы:- распределение раствора с pH<2 в первом (2) и втором (3) отделении электрохимической ячейки (1), причем каждое отделение содержит электрод (7; 6), предназначенный находиться в контакте с раствором, содержащимся в этом отделении, и первое и второе отделения отделены друг от друга средством (5), позволяющим проходить только электронам из одного отделения в другое;- подача электрического тока между двумя электродами (7; 6), чтобы запустить окислительно-восстановительную реакцию, причем уран из фракции раствора, содержащейся в одном из отделений, претерпевает восстановление, тогда как другая фракция раствора, содержащаяся в другом отделении, претерпевает окисление.3. Способ по п. 2, в котором средство (5), позволяющее проходить электронам, является спеченным материалом.4. Способ по п. 1, в котором эта РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 21/31 (13) 2013 117 129 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013117129/28, 13.09.2011 (71) Заявитель(и): АРЕВА НС (FR) Приоритет(ы): (30) Конвенционный приоритет: 16.09.2010 FR 1057407 (85) Дата начала ...

Method for measuring the permeability of superabsorbers

The invention relates to a method for measuring characteristic values of superabsorbers, wherein an excess aqueous solution or dispersion is presented, the superabsorber is allowed to swell in the presented aqueous solution or dispersion under agitation, a component A is dissolved or dispersed in the aqueous solution or dispersion, the concentration of component A in the aqueous solution or dispersion while the superabsorber is swelling is measured, the time-dependent swelling behaviour is measured by means of the concentration of component A in the aqueous solution or dispersion, and from this the swell constant k or the characteristic swell time τ is calculated, the characteristic value depends on the permeability of the superabsorber and the characteristic value is determined by means of a previously measured correlation between swell constant k and characteristic value or characteristic swell time τ and characteristic value.

Sensor arrangement for monitoring the conversion rate of an exhaust gas catalytic converter

A sensor arrangement monitors the conversion rate of an exhaust gas catalyst (1) arranged in the tail-pipe (6) of an internal combustion engine (16). The sensor arrangement has two element pairs composed each of an infrared radiation element and of an infrared sensor element (2.1/4.1 or 2.2/4.2) arranged opposite to the infrared radiation element with respect to the exhaust gas flow (5.1, 5.2). These pairs of infrared radiation elements and infrared sensor elements are arranged one adjacent to the input side and the other adjacent to the output side of the exhaust gas pipe (6, 7) of the catalyst (1). The spectral sensitivity of each pair is tuned to the absorption or emission spectrum of at least one gas, which is always the same, of the exhaust gas mixture. A comparator arrangement (26) receives the output signals of both infrared sensor elements (4.1, 4.2) or values calculated in the same manner from said output signals for both infrared sensor elements, and generates a signal from the output signals or calculated values. The signal contains information on changes of concentration of the gas in the exhaust gas mixture in the catalyst (1), thus on the conversion rate of the catalyst.

nitrite concentration measuring method

PURPOSE: A nitrate nitrogen concentration detection method is provided to simply implement detection procedures without the excessive pre-treatment of specimens. CONSTITUTION: A nitrate nitrogen concentration detection method includes the following steps: sulfanilic acid powder is added into a specimen containing nitrate nitrogen to be detected to induce color change; and the changed color degree of the specimen is compared with a color chart about a standard solution to the concentration of nitrate nitrogen. The sulfanilic acid powder is obtained by mixing chromotropic acid disodium salt, sodium sulfanilate, potassium pyrosulfate, potassium phosphate monobasic, and 1,2-cyclohexanediaminetetraacetic acid trisodium salt.

Apparatus and method for analyzing substance of object

비침습적으로 대상체의 성분을 분석하는 장치가 개시된다. 일 실시예의 중심에 배치된 이미지 센서 및 이미지 센서의 외곽에 배치된 복수의 광원을 포함하는 센서부 및, 광원을 구동하여 이미지 센서에 수광된 각 픽셀 강도(intensity)를 기초로 각 픽셀별 흡광도를 획득하고, 광원과 각 픽셀 간의 거리를 기초로 각 픽셀별 흡광도를 보정하며, 보정된 각 픽셀별 흡광도를 기초로 대상체의 성분을 분석하는 프로세서를 포함할 수 있다.

Portal

FIELD: physics. SUBSTANCE: portal or gateway has a vertical support, a detector having a chirped laser; an open optical cell for samples and a detector for detecting radiation from the chirped laser transmitted through the cell. The chirped laser can be a quantum cascade laser. EFFECT: invention increases sensitivity of detecting hazardous materials. 19 cl, 2 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 484 449 (13) C2 (51) МПК G01N 21/35 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009124429/28, 12.11.2007 (24) Дата начала отсчета срока действия патента: 12.11.2007 (73) Патентообладатель(и): КЭСКЕЙД ТЕКНОЛОДЖИЗ ЛИМИТЕД (GB) R U Приоритет(ы): (30) Конвенционный приоритет: 29.11.2006 GB 0622812.5 (72) Автор(ы): ХОУИСОН Ян (GB) (43) Дата публикации заявки: 10.01.2011 Бюл. № 1 2 4 8 4 4 4 9 (45) Опубликовано: 10.06.2013 Бюл. № 16 2 4 8 4 4 4 9 R U (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.06.2009 C 2 C 2 (56) Список документов, цитированных в отчете о поиске: US 2004/0124376 A1, 01.07.2004. WO 2006/090353 A1, 31.08.2006. US 2005/0230504 A1, 20.10.2005. US 2005/0157303 A1, 21.07.2005. US 2005/0124869 A1, 09.06.2005. US 2006/0196249 A1, 07.09.2006. US 2003/0085348 A1, 08.05.2003. RU 2129289 C1, 20.04.1999. (86) Заявка PCT: GB 2007/004333 (12.11.2007) (87) Публикация заявки РСТ: WO 2008/065338 (05.06.2008) Адрес для переписки: 129090, Москва, ул.Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. А.В.Мицу, рег.№ 364 (54) ПОРТАЛ (57) Реферат: Изобретение относится к средствам обеспечения безопасности, например, в аэропортах. Портал или шлюз включает в себя вертикальную опору, детектор, содержащий лазер с линейной модуляцией частоты, открытую оптическую ячейку для проб и детектор для обнаружения излучения от лазера с линейной модуляцией частоты, прошедшего через ячейку. Лазер с линейной модуляцией частоты может быть квантовым каскадным лазером. Изобретение ...