31-05-2018 дата публикации
Номер: US20180147316A1
Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are composed of (a) a polyanion in the absence of a polycation, wherein the polyanion comprises at least one crosslinking group capable of covalently crosslinking with itself, and (b) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate. The adhesives have numerous medical and non-medical applications. 1. An adhesive comprising a simple coacervate , wherein the simple coacervate comprises (a) a polyanion in the absence of a polycation , wherein the polyanion comprises at least one crosslinking group capable of covalently crosslinking with itself , and (b) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate.2. The adhesive of claim 1 , wherein the polyanion comprises a synthetic or naturally-occurring polymer comprising one or more sulfate claim 1 , sulfonate claim 1 , carboxylate claim 1 , borate claim 1 , boronate claim 1 , phosphonate claim 1 , phosphate groups claim 1 , or any combination thereof.3. The adhesive of claim 1 , wherein the polyanion comprises a polysaccharide claim 1 , a protein claim 1 , or a synthetic polypeptide.4. The adhesive of claim 1 , wherein the polyanion comprises an inorganic polyphosphate compound.7. The adhesive of claim 6 , wherein Ris methyl claim 6 , Ris hydrogen claim 6 , and n is 2.8. The adhesive of claim 2 , wherein the complimentary multivalent cation is Mg.9. The adhesive of claim 1 , wherein the crosslinking group comprises an actinically crosslinkable group.10. The adhesive of claim 9 , wherein the actinically crosslinkable comprises an acryloyl group or a methacryloyl group.11. The adhesive of claim 1 , wherein the simple coacervate further comprises one or more bioactive agents.12. The adhesive of claim 1 , wherein the simple coacervate further comprises one or more contrast agents.13. The ...
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