Method for analyzing aqueous ammonium carbamate solution, and method for operating unreacted gas absorber

There are provided a method for analyzing an aqueous ammonium carbamate solution whereby the composition of an unreacted-gas absorber outlet liquid can be specified in real time, and a method for operating an unreacted gas absorber by use of the same. The method for analyzing the composition of an aqueous ammonium carbamate solution includes determining ammonia component concentration, carbon dioxide component concentration, and water concentration of the aqueous ammonium carbamate solution, which is the unreacted-gas absorber outlet liquid in a urea production process, by using a correlation among viscosity, temperature, and carbon dioxide component concentration of the aqueous solution and a correlation among density, temperature, ammonia component concentration, and carbon dioxide component concentration of the aqueous solution, wherein the ammonia component concentration is a concentration of a sum of free ammonia and equivalent ammonia of ammonium carbamate which are contained in the aqueous solution, and the carbon dioxide component concentration is a concentration of equivalent carbon dioxide of ammonium carbamate contained in the aqueous solution.

Amine Detection Method and Materials

Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid are disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product. Diagnostic kits for detecting the presence of amines are also disclosed.

Method for Predicting the likelihood of an Onset of an Inflammation Associated Organ Failure

The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.

Method and Device for Detection of Nitroamines

An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.

Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS

The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.

Microfluidic dialysis device

A microfluidic dialysis device that has a first channel for receiving a biological sample, a second channel, and a series of adjacent channels extending between the first channel and the second channel. Each of the adjacent channels pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel. A bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the adjacent channels and is configured for uninterrupted capillary driven flow from the first channel to the second channel. Flow from the bypass channel reaches the meniscus pinned at each of the adjacent channels after the meniscus has formed to sequentially remove each of the menisci and allow flow from the first channel to the second channel via the adjacent channels as well as the bypass channel.

METHODS FOR QUANTITATIVE CHIRAL DETERMINATION OF THE d- AND l- ENANTIOMERS OF AMPHETAMINE AND METHAMPHETAMINE

Methods for the chiral separation and quantitative determination of the d- and l-enantiomers for amphetamine and methamphetamine in bodily fluids and tissues are provided. The method comprises providing a bodily fluid or tissue sample from a subject, extracting target analyte(s) from the sample, followed by eluting on a liquid chromatography column comprising a chiral stationary phase to yield an eluent, which is then analyzed for the presence of the analytes using a mass analyzer.

Optoelectrical vapor sensing

A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.

Nanofibril materials for highly sensitive and selective sensing of amines

A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A′ are independently chosen from N—R1, N—R2, and O such that both A and A′ are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.

Combined Illuminator/Light Collectors For Optical Readers

Combined illuminator/light collectors (I/LCs) that provide measurement and/or reference light to a target and collect light from the target. One example of a use for a combined I/LC of the present disclosure is for an optic of an optical reader used to read one or more chemical indicators that undergo physical changes that can be optically detected. The combined I/LC includes a spot lensing designed and configured in conjunction with the target to provide spot illumination on the target from one or more light sources. A light collector collects light from the target resulting from the spot illumination. Some embodiments further include dispersive lensing to direct a portion of the light from each light source away from the spot illumination to keep that light from interfering with the spot illumination.

COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK

Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock. 1. (canceled)2. A method for detecting putrescine , cadaverine , or a combination thereof , in a human having septic shock or non-septic shock , the method comprising:(i) obtaining a breath sample from the human;(ii) applying the sample to a solid carrier or a liquid carrier;(iii) detecting putrescine, cadaverine, or a combination thereof, in the solid carrier or the liquid carrier by infrared spectroscopy, ultraviolet spectroscopy, or visible spectroscopy; thereby detecting putrescine, cadaverine, or the combination thereof in the human having septic shock or non-septic shock.3. A method for detecting a volatile organic amine compound in a human having a shock condition , the method comprising:(i) obtaining a breath sample from the human;(ii) applying the sample to a solid carrier or a liquid carrier;(iii) detecting the volatile organic amine compound in the solid carrier or the liquid carrier; thereby detecting the organic amine compound in the human having the shock condition.4. The method of claim 3 , wherein the volatile organic amine compound comprises putrescine.5. The method of claim 3 , wherein the volatile organic amine compound comprises cadaverine.6. The method of claim 3 , wherein the volatile organic amine compound comprises putrescine and cadaverine.7. The method of claim 3 , wherein the shock condition is septic shock.8. The method of claim 3 , wherein the shock condition is non-septic shock.9. The method of claim 3 , further comprising quantifying the amount of volatile organic amine compound in the solid carrier or the liquid carrier.10. The method of claim 3 , wherein step (i) comprises obtaining and concentrating the breath sample.11. The method of claim 3 , wherein step (iii) comprises detecting the volatile organic amine ...

Multi-Parameter Water Analysis System with Analysis Application Updateable via a Cloud-Based Data Resource

Multi-parameter water analysis system with a water parameter sensing device configured to wirelessly provide detector data and a smart phone displayable indicator of water analysis test results that are calculated by an analysis application that is updateable via a cloud-based data resource to account for a manufacturing change in indicator chemistry and/or an improvement in test result display. The water parameter sensing device includes an optical sensing apparatus configured to detect light from each of a plurality of indicators for different parameters when the indicator and a chemical parameter are exposed to each other, a processor to process information of the detected light, and wireless communication circuitry for communicating detector data based on the information about the detected light to a remote device. Social networking of water quality data allows sharing to other users. 1. A multi-parameter water analysis system comprising: an optical sensing apparatus configured to detect light produced by an interaction of a chemical parameter in the water and an indicator when the indicator and the chemical parameter are exposed to each other, the indicator selected by a user, the optical sensing apparatus capable of detecting light from a plurality of different user selectable indicators for different chemical parameters in water;', 'a processor in communication with the optical sensing apparatus for receiving information about the detected light, the processor configured to process information about the detected light for a plurality of different indicators; and', 'a wireless communication circuitry in electrical connectivity with the processor for wirelessly communicating detector data based on the information about the detected light from the water parameter sensing device to a remote device; and, 'a water parameter sensing device includinga mobile smart phone device configured to display test results for the chemical parameter to the user, the test results ...

Colorimetric method to detect illicit drugs

A colorimetric assay to detect certain compounds and a kit therefore are provided.

Anise Flavored Medication

An anise flavored liquid medication. The liquid medication contains phenylephrine and an anethole analog that is substantially free of aldehyde groups. In one example, the anethole analog can be 1-methoxy-4-n-propylbenzene. 1. A liquid medication comprising:a. from about 0.01% to about 0.04% phenylephrine, by weight of the composition;b. from about 1% to about 3% of a pain reliever, by weight of the composition, wherein the pain reliever is selected from the group consisting of acetaminophen, ibuprofen, ketoprofen, naproxen, aspirin, and combinations thereof; andc. from about 2 ppm to about 5 ppm of an anethole analog, by weight of the composition, wherein the anethole analog is selected from the group consisting of 1-methoxy-4-n-propylbenzene, methyl anisate, anisole, 2-chloroanethole, 2,6-dichloroanethole, 3-nitroanethole, 3,5-dinitroanethole, 3-cyanoanethole, 3,5-dicyanoanethole, 1-methoxy-3-(1-propenyl)benzene, and combinations thereof.2. The liquid medication of wherein the phenylephrine is phenylephrine hydrochloride.3. The liquid medication of further comprising from about 0.01% to about 0.2% of an antitussive claim 2 , by weight of the composition claim 2 , wherein the antitussive is selected from the group consisting of dextromethorphan HBr claim 2 , chlophedianol claim 2 , levodropropizine claim 2 , and combinations thereof.4. The liquid medication of further comprising from about 3% to about 15% ethanol claim 3 , by weight of the composition.5. The liquid medication of further comprising from about 3% to about 15% glycerin claim 4 , by weight of the composition.6. The liquid medication of further comprising doxylamine succinate.7. The liquid medication of comprising from about 0.03% to about 0.05% doxylamine succinate claim 6 , by weight of the composition.8. The liquid medication of further comprising guaifenesin.9. The liquid medication of wherein the anethole analog is 1-methoxy-4-n-propylbenzene.10. The liquid medication of wherein the anethole analog ...

POLYCATIONIC QUATERNARY AMMONIUM POLYMER COATINGS FOR IMMOBILIZING BIOLOGICAL SAMPLES

The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA). 148.-. (canceled)49. A coated substrate for immobilizing a biological sample for analysis , comprising:a substrate, wherein the substrate is a glass slide; anda coating comprising a non-peptidic quaternary ammonium polymeric material having an average molecular weight greater than 350,000 Da, wherein the coating allows cells in a biological sample to be immobilized directly thereon when brought into contact with the biological sample.50. The coated substrate of claim 49 , wherein the non-peptidic quaternary ammonium polymeric material comprises a monomer selected from the group consisting of diallyldimethylammonium claim 49 , methylacrylamidopropyltrimethylammonium claim 49 , methacryloyloxyethyltrimethylammonium claim 49 , 4-vinyl-benzyltrimethyl ammonium claim 49 , acryloxyethyldimethylbenzyl ammonium claim 49 , acryloxyethyltrimethyl ammonium claim 49 , dimethylaminoethylmethacrylate claim 49 , methacryloxyethyldimethyl ammonium claim 49 , methacryloxyethyltrimethylbenzylammonium claim 49 , trimethyl-2-methacryloylethylammonium claim 49 , trimethyl-2-methacrylaminopropylammonium claim 49 , or a mixture thereof.51. The coated substrate of claim 49 , wherein the non-peptidic quaternary ammonium polymeric material is a homopolymer.52. The coated substrate of claim 49 , wherein the ...

COMPOSITIONS AND METHODS FOR DIAGNOSIS OF SHOCK

Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock. 1. (canceled)2. A method for detecting putrescine , cadaverine , or a combination thereof , in a human having septic shock or non-septic shock , the method comprising:(i) obtaining a breath sample from the human;(ii) applying the sample to a solid carrier or a liquid carrier;(iii) detecting putrescine, cadaverine, or a combination thereof, in the solid carrier or the liquid carrier by infrared spectroscopy, ultraviolet spectroscopy, or visible spectroscopy; thereby detecting putrescine, cadaverine, or the combination thereof in the human having septic shock or non-septic shock.3. A method for detecting a volatile organic amine compound in a human having a shock condition , the method comprising:(i) obtaining a breath sample from the human;(ii) applying the sample to a solid carrier or a liquid carrier;(iii) detecting the volatile organic amine compound in the solid carrier or the liquid carrier; thereby detecting the organic amine compound in the human having the shock condition.4. The method of claim 3 , wherein the volatile organic amine compound comprises putrescine.5. The method of claim 3 , wherein the volatile organic amine compound comprises cadaverine.6. The method of claim 3 , wherein the volatile organic amine compound comprises putrescine and cadaverine.7. The method of claim 3 , wherein the shock condition is septic shock.8. The method of claim 3 , wherein the shock condition is non-septic shock.9. The method of claim 3 , further comprising quantifying the amount of volatile organic amine compound in the solid carrier or the liquid carrier.10. The method of claim 3 , wherein step (i) comprises obtaining and concentrating the breath sample.11. The method of claim 3 , wherein step (iii) comprises detecting the volatile organic amine ...

Hydrophilic thiol probe

The present invention provides a probe that further promotes ionization in proteomic analysis using mass spectrometry, and a high-sensitive mass spectrometry method for a protein using such a probe. Further, the present invention provides an ionization-enhancing probe that can be used even for a protein that has a high degree of hydrophobicity and quickly turns over, and a high-sensitive mass spectrometry method for a protein using such a probe. A thiol probe for a protein, which is represented by the following formula (I): [Chemical Formula 1] wherein R 1 represents a linker group, and R 2 represents a substituted ammonium group or a substituted amino group. A mass spectrometry method for a protein, comprising the steps of: obtaining a modified protein by reacting the thiol probe with a protein to be subjected to mass spectrometry; and subjecting the modified protein to mass spectrometry.

Anise Flavored Medication

An anise flavored liquid medication. The liquid medication contains phenylephrine and an anethole analog that is substantially free of aldehyde groups. In one example, the anethole analog can be 1-methoxy-4-n-propylbenzene.

Means and Methods for Diagnosing and Monitoring Heart Failure in a Subject

The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

System and process for quantifying potentially mineralizable nitrogen for agricultural crop production

The invention is generally directed to a system and process for fluorometrically quantifying potentially mineralizable nitrogen for agricultural crop production. The soil analysis process measures potentially mineralizable nitrogen and calibrates the application of soil-based nitrogen for site or field specific management of nitrogen fertilizers for crops grown on a wide variety of soil textures including sandy loam, silt loam and clay soils. The spectrofluorometric system and process may be utilized for routine soil testing with a lower sample to sample variability, and the automation of the spectrofluorometric system and process allows for simultaneous determination of potentially mineralizable soil organic nitrogen, ammonium and nitrate.

DEVICE FOR DETECTING ANALYTE IN SAMPLE

A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple. 1. A device for detecting an analyte in a sample , comprising:a) a collecting chamber having an opening for collecting a liquid sample;b) a detecting chamber having a detecting element for detecting the analyte in the liquid sample;c) a lid having a circumferential lid edge, the lid being configured to cover the opening; andd) an indicating device configured to indicate whether or not the lid covers the opening at an appointed position,wherein the indicating device generates a sound when the lid covers the opening at the appointed position resulting from elastic deformation and rebound of an element disposed on the collecting chamber upon interaction with an element disposed on the lid edge, andwherein the sound indicates formation of a liquid tight seal of the opening and the start of a detection assay by the detecting element when in use, and wherein a detection result is displayed on the detecting element after an allotted time starting from the generation of the sound.2. The device of claim 1 , wherein the element disposed on the lid edge is non-elastic and the element disposed on the collecting chamber is elastic.3. The device of claim 2 , wherein the lid and the collecting chamber are in rotatable engagement via a threaded connection.4. The device of claim 3 , wherein rotational movement of the lid with respect to the collecting chamber causes the sound to be generated upon contact of the element disposed on the collecting chamber with the lid edge after elastic deformation of the element disposed on the collecting ...

METHODS FOR ANALYZING CYSTEAMINE COMPOSITIONS

Methods of analyzing purity of compositions comprising cysteamine and detecting impurities in cysteamine compositions are described. 1. A method of analyzing purity of a composition comprising cysteamine comprising:(i) injecting a sample solution comprising cystcamine onto a reverse-phase HPLC column;(ii) eluting the sample from the column using a mobile phase comprising an alkyl sulfonic acid, a buffer, acetonitrile, and methanol; and(iii) measuring the eluted sample using a UV detector at a wavelength of about 170 nm to about 250 nm.2. The method of claim 1 , further comprising dissolving a cysteamine sample in a solvent having an acidic pH to form the sample solution comprising cysteamine.3. A method of analyzing purity of enteric-coated cysteamine beads comprising:(i) grinding enteric-coated cysteamine beads;(ii) dissolving the ground beads in a solvent having an acidic pH to form a sample solution comprising cysteamine;(iii) injecting the sample solution onto a reverse-phase HPLC column;(iv) eluting the sample from the column using a mobile phase comprising an alkyl sulfonic acid, a buffer, acetonitrile, and methanol; and(v) measuring the eluted sample using a UV detector at a wavelength of about 170 nm to about 250 nm.4. The method of or claim 1 , wherein the solvent comprises an alkyl sulfonic acid claim 1 , a buffer claim 1 , acetonitrile claim 1 , and methanol.5. The method of any of the preceding claims claim 1 , wherein the HPLC column is selected from the group consisting of a C18 column claim 1 , a C8 column claim 1 , a silica column claim 1 , a cyano-bonded silica column claim 1 , and a phenyl-bonded silica column.6. The method of any of the preceding claims claim 1 , wherein the HPLC column has a packing material particle size of about 1 μm to about 10 μm in diameter.7. The method of any of the preceding claims claim 1 , wherein the HPLC column has a packing material particle size of about 2 μm to about 5 μm in diameter.8. The method of any of the ...

METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY

A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland. 1. A method of treating meibomian gland dysfunction , comprising the steps of:positioning a first RF electrode proximate an inner surface of an eyelid containing at least one meibomian gland;positioning a second RF electrode proximate an external surface of the eyelid;directing RF energy via at least one of the first RF electrode and the second RF electrode to an internal portion of a meibomian gland;selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction; andexpressing the obstruction from the duct of the meibomian gland.2. The method of claim 1 , further comprising directing the RF energy until an increase in thermal energy occurs at the obstruction in the duct.3. The method of claim 1 , wherein the selectively targeting further comprises directing RF energy waveforms such the RF energy waveforms are absorbed preferentially by energy absorbing cellular fluids claim 1 , saline or lipid containing materials found in the duct of the meibomian gland.4. The method of claim 1 , wherein ...

METHOD AND DEVICE FOR MONITORING MEDICATION USAGE

The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately. 1. A method of determining a drug dose taken by a subject , the method comprising:(a) determining a concentration of a test metabolite and a reference metabolite in a biological sample obtained from a subject, wherein the test metabolite is the drug or a metabolite of the drug;(b) determining the normalized concentration of the test metabolite in the biological sample as a ratio of the concentration of the test metabolite to the concentration of the reference metabolite; and(c) determining the drug dose taken by the subject by using a database to determine the drug dose that is correlated with the normalized concentration of the test metabolite obtained in step (b), wherein the database comprises (i) dose of the drug taken by a reference population; (ii) reference metabolite concentration in a medium of biological sampling obtained from the reference population, and (iii) test metabolite concentration in the medium of biological sampling obtained from the reference population.2. The method of claim 1 , wherein the biological sample and the medium of biological sampling are selected from the group consisting of: urine claim 1 , blood claim 1 , saliva claim 1 , sweat claim 1 , spinal fluid claim 1 , brain fluid claim 1 , and combinations thereof.3. The method of claim 1 , wherein the reference metabolite is creatinine.4. The method of claim 1 , wherein concentration of the reference metabolite is determined by contacting the biological sample ...

Anise Flavored Medication

An anise flavored liquid medication. The liquid medication contains phenylephrine and an anethole analog that is substantially free of aldehyde groups. In one example, the anethole analog can be 1-methoxy-4-n-propylbenzene. 1. A liquid medication comprising:a. phenylephrine hydrochloride; andb. an anethole analog that is substantially free of aldehyde groups.2. The liquid medication of comprising from about 0.01% to about 0.1% phenylephrine hydrochloride.3. The liquid medication of comprising from about 1 ppm to about 20 ppm anethole analog.4. The liquid medication of wherein the anethole analog is 1-methoxy-4-n-propylbenzene.5. The liquid medication of comprising 1 ppm to 10 ppm 1-methoxy-4-n-propylbenzene.6. The liquid medication of further comprising a pain reliever selected from the group consisting of acetaminophen claim 1 , ibuprofen claim 1 , and combinations thereof.7. The liquid medication of wherein the pain reliever is acetaminophen.8. The liquid medication of further comprising dextromethorphan.9. The liquid medication of further comprising doxylamine succinate.10. The liquid medication of further comprising from about 3% to about 15% ethanol.11. The liquid medication of wherein the medication has a pH of about 2 to about 6.12. The liquid medication of wherein the liquid medication has a mean loss of phenylephrine of less than about 6% within a 95% confidence interval.13. The liquid medication of further comprising a synthetic sweetener selected from the group consisting of sodium saccharin claim 1 , acesulfame potassium claim 1 , sucralose claim 1 , aspartame claim 1 , monoammonium glycyrrhizinate claim 1 , neohesperidin dihydrochalcone claim 1 , thaumatin claim 1 , neotame claim 1 , cyclamates claim 1 , and mixtures thereof.14. The liquid medication of further comprising a sugar alcohol selected from the group consisting of xylitol claim 15 , sorbitol claim 15 , mannitol claim 15 , maltitol claim 15 , lactitol claim 15 , isomalt claim 15 , erthritol ...

Nanofibril Materials for Highly Sensitive and Selective Sensing of Amines

A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A′ are independently chosen from N—R1, N—R2, and O such that both A and A′ are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.

DETECTION DEVICE FOR DETECTING ANALYTES IN LIQUID SPECIMEN

A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided. 1. A method for detecting analytes in specimen , comprising:a) providing a device, which comprises a detecting chamber for containing a detecting element, a collecting chamber for collecting liquid specimen, and a through hole that can be either in its first status or self-sealed status, through which whether or not the collecting chamber is in liquid communication with the detecting chamber is controlled, wherein, the through hole is self-sealed in the first status, and is opened in the second status;b) shifting the through hole from the first status to second status, thus allowing part of the liquid specimen to flow into the detecting chamber from the collecting chamber via the through hole and starting the detection process.2. The method of claim 1 , further comprising: using a rod that is applied on the through hole to control the through hole; when the rod is pushed to move from a first position to a second position claim 1 , the through hole is accordingly changed to the second status from the first status.3. The method of claim 1 , wherein claim 1 , the through hole is on and thereby controlled by a flexible element; when the flexible element is in a first status claim 1 , the through hole is in its first status claim 1 , and when the flexible element is in a second status claim 1 , the through hole is in its second status.4. The method of claim 3 , further comprising: using a ...

Ultra low range chlorine measurement

An embodiment provides a method for measuring total chlorine in a solution, including: preparing a thiocarbamate indicator; introducing the thiocarbamate indicator to a solution, wherein the solution contains an amount of monochloramine; adding an additive to the solution, wherein the additive accelerates the reaction rate between the thiocarbamate indicator and monochloramine and causes a change in fluorescence of the solution; and measuring the amount of monochloramine in the solution by measuring an intensity of the fluorescence. Other aspects are described and claimed.

Amine-containing compound analysis methods

The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.

Multiplexed active biologic array

A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.

Multiplexed active biologic array

An improved biologic electrode array (12) and methods for using the same. Each electrode (30) in the array (12) is coupled to a respective sample-and-hold circuit (26). The electrodes (30) and sample-and-hold circuits (26) are integral and form an array (12) within a single semiconductor chip, such that each sample-and-hold circuit (26) may be loaded (37) with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC) (22). All of the sample-and-hold circuits (26) may be accessed through a multiplexer which may scan through some or all of the electrode locations (30). Each sample-and-hold circuit (26) may comprise a capacitor (32) and one or more transistor switches (34, 36), the switches (34, 36), when closed providing electrical communication between the capacitor (32) and a source line (37) formed in the matrix (12).

Universal detector calibrant

A method of calibrating a biological detector can include training a biological detector to detect a calibration compound, wherein the calibration compound has an odor that is detectable by the biological detector and is not used in an environment for which the biological detector is trained to detect odors, presenting the biological detector with a device comprising the calibration compound, and determining whether the biological detector will alert to the calibration compound.

Multiplexed active biologic array

본 발명은 개선된 바이오로직 전극 어레이(12) 및 이를 사용하기 위한 방법이다. 어레이(12) 내의 각 전극(30)은 각각의 샘플 앤드 홀드 회로(26)에 결합된다. 전극(30) 및 샘플 앤드 홀드 회로(26)는, 각각의 샘플 앤드 홀드 회로(26)가 단일 시분할 디지탈/아날로그 변환기(DAC)(22)에 의해서 제공된 선정된 전압으로 (37)을 로드시킬 수 있도록, 단일 반도체 칩 내에 어레이(12)를 집적화시켜 형성된다. 모든 샘플 앤드 홀드 회로(26)는 일부 또는 전체 전극 위치부(30)를 통해서 스캔될 수 있는 멀티플렉서를 통해서 액세스될 수 있다. 각각의 샘플 앤드 홀드 회로(26)는 캐패시터(32) 및 하나 이상의 트랜지스터 스위치(34, 36)를 포함하며, 상기 스위치(34, 36)가 닫힐 때 매트릭스(12) 내에 형성된 캐패시터(32)와 소스 선(37) 사이에 전기적으로 접속시킨다. The present invention is an improved biologic electrode array 12 and a method for using the same. Each electrode 30 in the array 12 is coupled to a respective sample and hold circuit 26. Electrode 30 and sample and hold circuit 26 allow each sample and hold circuit 26 to load 37 with a predetermined voltage provided by a single time division digital / analog converter (DAC) 22. In such a way, it is formed by integrating the array 12 in a single semiconductor chip. All sample and hold circuits 26 can be accessed through a multiplexer, which can be scanned through some or all electrode positions 30. Each sample and hold circuit 26 includes a capacitor 32 and one or more transistor switches 34 and 36, the capacitor 32 and the source formed in the matrix 12 when the switches 34 and 36 are closed. The wires 37 are electrically connected to each other. 바이오로직 어레이 Biologic Array

Carboxyl-terminal protein sequencing method and kit

Polypeptides are sequenced from the carboxyl terminus by treating the peptide with an iodoxybenzene, followed by removal of the excess reagent and reaction with 2-aminothiophenol at an elevated temperature. The resulting benzthiazolidine is then analyzed to determine the C-terminal amino acid which has been cleaved. A kit which contains the iodoxybenzene and 2-aminothiophenol reagents is separate containers is also disclosed.

Devices and methods for the detection of basic gases

This invention provides a fiber optic sensor and sensor devices for the reversible detection of basic gas analytes, including hydrazine, alkyl hydrazines, amines, ammonia, and related chemical species. The optical fiber sensor is formed in an optical fiber which conventionally comprises an optical fiber core and a cladding layer. Transducer molecules are immobilized in contact with an exposed surface of the fiber core to allow interaction of the immobilized species with analytes in the environment around the sensor. Preferred transducer molecules for detection of basic gases, particularly hydrazine and hydrazine derivatives, are xanthene dyes and triphenylmethane dyes, including malachite green and crystal violet. The sensors of this invention can be employed in a variety of device configurations including single-site sensors and multiple-site sensor networks.

Neurotoxin sensor based on chromophoric polymers

Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.

Luminescent detection of hydrazine and hydrazine derivatives

The present invention generally relates to methods for modulating the optical properties of a luminescent polymer via interaction with a species (e.g., an analyte). In some cases, the present invention provides methods for determination of an analyte by monitoring a change in an optical signal of a luminescent polymer upon exposure to an analyte. Methods of the present invention may be useful for the vapor phase detection of analytes such as explosives and toxins. The present invention also provides methods for increasing the luminescence intensity of a polymer, such as a polymer that has been photobleached, by exposing the luminescent polymer to a species such as a reducing agent.

Synthesis of quinazolinone libraries and derivatives thereof

Porous optical sensor with fiducial marker and method for detection of analytes

The invention provides a porous sensor and sensing methods that use a porous sensor with a porous nanostructure having an optical response and having a portion of the porous nanostructure filled with a fiducial marker that is non-reactive to an analyte of interest. In a preferred sensing method, reflectance spectra from both the fiducial marker and reactive portions of the porous structure are acquired simultaneously. The fiducial marker provides an internal reference that permits compensation for humidity, as well as off angle measurements. In addition, simple visual observations can reveal the presence of an analyte, including human observations.

Fluorescent chemical sensor

A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.

Fluorescent chemical sensor

A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.

Polymeric fluorescent chemical sensor

A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.

Fluorescent chemical sensor

Fluorescent chemical sensor

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e. Polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene.

Methods and systems for treating meibomian gland dysfunction using radio-frequency energy

A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.

Method of assay of electrone-saturated aromatic amine which is a marker of analyte content in biological fluid, and an agent for its realization

FIELD: medicine. SUBSTANCE: analyte is converted with substance that forms electrone-saturated amine which contacts with difficultly soluble salt of heteropolyacid. Agent for realization has difficultly soluble salt of heteropolyacid at concentration sufficient for conversion of amine to heteropolyblue compound. EFFECT: improved method of assay. 12 cl, 7 dwg, 4 tbl 63 СсС90с ПЧ Го РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (19) (51) МПК ВИ” 2 052 819 ' 13) Сл С 01 М 33/48 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 4894061/14, 30.11.1990 (30) Приоритет: 02.12.1989 ОЕ Р 3940010.7 (46) Дата публикации: 20.01.1996 (56) Ссылки: Сп. Спет. 1966, 12, р.816-823. (71) Заявитель: Берингер Маннхайм ГмбХ (0Е) (72) Изобретатель: Йоахим Хенес[ОЕ], Ханс Вилингер[АТ], Фолькер Ункри[ОЕ] (73) Патентообладатель: Берингер Маннхайм ГмбХ (0Е) (54) СПОСОБ ОПРЕДЕЛЕНИЯ ЭЛЕКТРОНОНАСЫЩЕННОГО АРОМАТИЧЕСКОГО АМИНА, ЯВЛЯЮЩЕГОСЯ МАРКЕРОМ СОДЕРЖАНИЯ АНАЛИТА В БИОЛОГИЧЕСКОЙ ЖИДКОСТИ, И СРЕДСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ (57) Реферат: Использование: в медицине, для определения аналита при помощи образования гетерополисинего. Сущность: аналит превращают с веществом, которое приводит к электрононасыщенному амину, который вступает В контакт С труднорастворимой солью гетерополикислоты. Средство для осуществления способа содержит труднорастворимую соль гетерополикислоты в количестве, достаточном для перевода всего амина в гетерополисиний. 2 си 2 3. п. ф-лы, 7 ил., 4 табл. 2052819 С1 КО 63 СсС90с ПЧ Го (19) 13) ВО “” 2052 819 ' (51) 1пё. С1.6 С 01 М 33/48 СЛ КУЗЗАМ АСЕМСУ ГОК РАТЕМТ$ АМО ТКАОЕМАКК$ 12) АВЗТКАСТ ОЕ 1МУЕМТОМ (21), (22) АррИсаНоп: 4894061/14, 30.11.1990 (71) АррИсапЕ: Вегтпдег Маппква]т СтЬКИ (0Е) (30) Рпощу: 02.12.1989 ОЕ Р 3940010.7 (72) пуетог. — Уоакит Квепез[ОЕ], (46) а оГ рибИсаноп: 20.01.1996 КНапз УИтдае АТ], Ро!Кег Упкма[ОЕ] (73) Ргорпеюг: Вегпдег Маппкпа]т СтЬКА (0Е) (54) МЕТНОО ОЕ АЗЗАУ ОЕ ЕТЕСТКОМЕ-ЗАТУКАТЕО АКОМАТ!С АММЕ МУН!СН 1$ А МАККЕК ОР ...

Detecting Method of fish-like smell from Air Conditioner and Reproducing Method thereof, and the fish-like smell Composition the same

본 발명은 에어컨에서 발생하는 비린 냄새의 성분을 구성하는 화합물의 분류를 확인하고, 이를 재현하여 인위적으로 비린 냄새를 제조하는 방법 및 비린 냄새 조성물에 관한 것이다. 본 발명의 분석 방법을 통해 에어컨에서 발생하는 비린 냄새를 구성하는 화합물의 구체적인 성분 및 해당 농도를 확인할 수 있으며, 재현도 가능하다. 또한, 상기 재현된 비린 냄새를 제거하기 위하여 특정의 냄새 제거 장치, 제거 방법을 개발하기 위한 유의미한 데이터를 제공할 수 있으며, 상기 방법을 통해 비린 냄새 이외의 냄새를 재현하는 데에 다방면으로 활용될 수 있다. TECHNICAL FIELD The present invention relates to a method for identifying a compound constituting a component of the odor generated in an air conditioner and reproducing the same to artificially produce an odorous odor. Through the analysis method of the present invention, it is possible to confirm and reproduce the specific constituents and the concentration of the compound constituting the bad breath odor generated in the air conditioner. In addition, it is possible to provide meaningful data for developing a specific deodorizing device and a removing method for eliminating the above-described odor of reproduced virgin, and can be used in various ways to reproduce the odor other than the odor of the odor have.

Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof

The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.

Method of determining polysorbate

FIELD: chemistry. SUBSTANCE: method according to the present invention includes the pretreatment of a sample via alkaline hydrolysis, followed by colorimetric determination based on the metal complex, which is determined during substance analysis with a thiocyanate agent, wherein the said complex is extracted by a water-immiscible organic solvent. EFFECT: alkaline hydrolysis leads to the removal of interfering proteins and increases selectivity with respect to the surfactants which are similar to the substance being determined during analysis, for example Tween 80 selectivity relative to Triton X-100. 15 cl, 6 dwg, 3 tbl, 8 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 33/50 (13) 2 583 132 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013144587/15, 01.03.2012 (24) Дата начала отсчета срока действия патента: 01.03.2012 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 10.04.2015 Бюл. № 10 (73) Патентообладатель(и): БАКСТЕР ИНТЕРНЭШНЛ ИНК. (US), БАКСТЕР ХЕЛТКЭАР С.А. (CH) R U 04.03.2011 US 61/449,535 (72) Автор(ы): ВЕБЕР Альфред (AT), ЭНГЕЛЬМАЙЕР Андреа (AT), АНДЕРЛЕ Хайнц (AT), ШВАРЦ Ганс-Петер (AT) (45) Опубликовано: 10.05.2016 Бюл. № 13 2 5 8 3 1 3 2 (56) Список документов, цитированных в отчете о поиске: СN 101639439, 03.02.2010. RU 2163379, 20.02.2001. CN 101852739, 06.10.2010. (85) Дата начала рассмотрения заявки PCT на национальной фазе: 04.10.2013 (86) Заявка PCT: EP 2012/000898 (01.03.2012) 2 5 8 3 1 3 2 R U WO 2012/119724 (13.09.2012) C 2 C 2 (87) Публикация заявки PCT: Адрес для переписки: 109012, Москва, ул. Ильинка, 5/2, ООО "Союзпатент" (54) СПОСОБ ОПРЕДЕЛЕНИЯ ПОЛИСОРБАТА (57) Реферат: Настоящее изобретение относится к области аналитической химии и касается способа определения полисорбата в пробе, содержащей белок. Способ по настоящему изобретению включает предварительную обработку пробы посредством щелочного гидролиза с последующим колориметрическим ...

Method for the determination of polysorbate

본 발명은 단백질-함유 샘플 내의 폴리소르베이트의 측정 방법에 관한 것이다. 본 발명의 방법은, 알칼리 가수분해를 통해 샘플을 전처리하고, 이어서 분석물과 티오시아네이트 시약의 금속 착물을 형성하고 상기 착물을 비혼화성 유기 용매 내로 추출함에 기반을 둔 비색 측정을 포함한다. 알칼리 가수분해는 간섭하는 단백질의 제거를 설명하고, 분석물과 유사한 계면활성제에 대한 선택성, 예를 들어 트리톤 X-100에 대한 트윈 80의 선택성을 향상시킨다. The present invention relates to a method of measuring polysorbates in protein-containing samples. The method of the present invention comprises colorimetric determination based on pretreatment of the sample through alkaline hydrolysis followed by formation of the metal complex of the analyte and the thiocyanate reagent and extraction of the complex into the incompatible organic solvent. Alkaline hydrolysis accounts for the removal of interfering proteins and enhances the selectivity for surfactants similar to analytes, such as the selectivity of Tween 80 to Triton X-100.

Use of sparingly soluble salt of heteropoly acid for determination of analyte, corresponding method of determination as well as suitable agent therefor

本发明涉及微溶性杂多酸盐在测定被分析物中的应用，特别可用于被分析物是富电子芳香胺，或者被分析物与能与另一其他物质反应产生富电子芳香胺的情况。本发明还涉及借助生成杂多蓝来测定被分析物的方法。此方法的特征在于先将被分析物与一物质反应产生一种富电子芳香胺，再使胺与微溶性杂多酸盐以及相应试剂接触。

Nucleic acid purification method and nucleic acid purification instrument

Liquid reagent of color former and method of stabilizing the same

本发明提供在液体状态下稳定地保存亚甲蓝显色剂的液体试剂以及在液体状态下使亚甲蓝系显色剂稳定化的方法。通过在液体介质中使亚甲蓝系显色剂与具有碳原子数为12以上的烃基的季铵或其盐共存，使其稳定化。亚甲蓝系显色剂例如可以举出10-(羧甲基氨基羰基)-3，7-双(二甲基氨基)吩噻嗪。

Oxygen indicator

An oxygen indicator comprising (a) at least one aliphatic organic compound having 3 or more carbon atoms and containing at least one primary amine group and at least one hydroxy group and optionally an organic or inorganic acid or the chemically bonded material of the organic compound and the acid, and (b) at least one dyestuff selected from the group consisting of thiazine dyestuffs, indigo dyestuffs and mixtures thereof is disclosed. The oxygen indicator of this invention can be used under anhydrous conditions and under presence of light.

3-CARBOXYPROPYL-AMINOTETRALINE DERIVATIVES AND RELATED COMPOUNDS AS MU-OPIOID RECEPTOR ANTAGONISTS

1. Соединение формулы (I): ! ! в которой R1 обозначает -ORa или -C(O)NRbRc; ! R2, R3 и R4 обозначают каждый независимо C1-3алкил; ! R5 выбран из C1-6алкила, фенила, циклогексила, -(CH2)1-3-циклогексила и ! -(CH2)1-3-фенила; ! Ra, Rb и Rc обозначают каждый независимо водород или C1-3алкил; и ! R6 обозначает водород или C1-3алкил; и ! в которой заместители в хиральных центрах, отмеченных звездочками, находятся в конфигурации транс; ! или его фармацевтически приемлемая соль. ! 2. Соединение по п.1, в котором R1 обозначает -OH или -C(O)NH2. ! 3. Соединение по п.1, в котором R1 обозначает -C(O)NH2. ! 4. Соединение по п.1, в котором R2 и R3 обозначают каждый независимо метил или этил. ! 5. Соединение по п.1, в котором R2 и R3 обозначают этил. ! 6. Соединение по п.1, в котором R4 обозначает метил. ! 7. Соединение по п.1, в котором R5 выбран из C3-5алкила, циклогексила, -(CH2)1-3-циклогексила и -(CH2)1-3-фенила. ! 8. Соединение по п.1, в котором R5 обозначает циклогексилметил. ! 9. Соединение по п.1, в котором R6 обозначает водород. ! 10. Соединение по п.1, в котором R6 обозначает метил. ! 11. Соединение по п.1, в котором хиральные центры имеют стереохимию (2S),(3S), как показано в формуле (Ia): !! 12. Соединение по п.1, выбранное из следующих соединений: ! (S)-4-((2S,3S)-7-карбамоил-1,1-диэтил-3-метокси-1,2,3,4-тетрагидро-нафталин-2-иламино)-2-циклогексилметил-масляная кислота; ! метиловый эфир (S)-4-((2S,3S)-7-карбамоил-1,1-диэтил-3-метокси-1,2,3,4-тетрагидро-нафталин-2-иламино)-2-циклогексилметил-масляной кислоты; ! метиловый эфир (S)-4-((2R,3R)-7-карбамоил-1,1-диэтил-3-метокси-1,2,3,4-тетрагидро-нафталин-2-иламино)-2-циклогексилметил-масляной кислоты; ! метиловый эфир (S)-2-[2-((2S,3S)-7-карбамоил-1,1-диэтил-3-метокси-1,2,3,4-тетрагидро-нафталин-2-иламино)-этил]-4-метил-пентановой кислоты; ! (19) РОССИЙСКАЯ ФЕДЕРАЦИЯ RU (11) 2010 128 542 (13) A (51) МПК C07C 215/64 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (71) Заявитель(и ...

Method for predicting the likelihood of an onset of an inflammation associated organ failure

The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.

Method of diagnosing organ failure

The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method, and finally, the present invention relates to a Kit for carrying out said method.

External dried-reagent control for analytical test devices

A control device serving as a source of control reagent for a solid-phase analytical test device is disclosed. The analytical test device analyzes a biological sample for the presence of an analyte such as an enzyme or other chemical species or a particular pH range, and registers the presence or absence of the analyte as a detectable change in an indicator. The control device contains a control reagent that produces the same indicator change and that can be transferred to the analytical test device by a sample implement such as a wet swab. The control reagent is present on the control device as a dry lamina or combination of laminae. A positive control reagent on a control device in accordance with this invention mimics the action of the analyte once it is transferred to the analytical test device, while a negative control reagent on the control device mimics the action of a sample that lacks the analyte.

Method to increase specificity and/or accuracy of lateral flow immunoassays

The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.

Integrated optoelectrochemical sensor for nitrogen oxides in gaseous samples

A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

Integrated optoelectrochemical sensor for nitrogen oxides in gaseous samples

一个基于检测光化学及光电化学信号的气相检测系统。感应平台尤其对低ppbV浓度的氧化氮的检测作用显著。由于化学反应发生在优化的材料中，光化学分析基于彩色显影。电化学分析可基于电化学传感器的掺杂度或氧化还原电势的变化；而光电化学探测可基于电化学和光电化学方法的联合。每个独立的信号可被同时检测，以提高检测的可靠性。

Integrated optoelectrochemical sensor for nitrogen oxides in gaseous samples

A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

Integrated optoelectrochemical sensor for nitrogen oxides in gaseous samples

A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

METHOD FOR DETERMINING POLYSORBATE

1. Способ определения полисорбата в содержащей белок пробе, включающий следующие стадии:(a) пробу подвергают щелочному гидролизу;(b) после щелочного гидролиза пробу нейтрализуют;(c) из нейтрализованной пробы необязательно удаляют осадок денатурированного белка;(d) к необязательно профильтрованной пробе добавляют водную смесь тиоцианатного металлокомплекса для образования тиоцианатного металлокомплекса полиоксиэтиленсорбитана;(e) упомянутый тиоцианатный металлокомплекс полиоксиэтиленсорбитана, образовавшийся на стадии (d), экстрагируют несмешивающимся с водой органическим растворителем;(f) измеряют поглощение экстракта, полученного на стадии (e), для определения количества упомянутого тиоцианатного металлокомплекса полиоксиэтиленсорбитана, образовавшегося на стадии (d); и(g) рассчитывают количество содержащегося в пробе полисорбата, исходя из количества упомянутого тиоцианатного металлокомплекса полиоксиэтиленсорбитана, определенного на стадии (f).2. Способ по п.1, в котором полисорбат представляет собой моноолеат полиоксиэтиленсорбитана (полисорбат 80).3. Способ по п.2, в котором полисорбат 80 имеет животное происхождение.4. Способ по п.2, в котором полисорбат 80 имеет растительное происхождение.5. Способ по любому из пп.1-4, в котором тиоцианатный металлокомплекс, добавляемый на стадии (d), представляет собой водную смесь Co(NO)·6HO и NHSCN, а образующийся тиоцианатный металлокомплекс полиоксиэтиленсорбитана представляет собой полиоксиэтиленсорбитановый комплекс тиоцианатокобальтата(II).6. Способ по п.5, в котором упомянутая водная смесь включает около 3% (масс./об.) Co(NO)·6HO и около 20% (масс./об.) NHSCN.7. Способ по любому из пп РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 33/50 (13) 2013 144 587 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013144587/15, 01.03.2012 (71) Заявитель(и): БАКСТЕР ИНТЕРНЭШНЛ ИНК. (US), БАКСТЕР ХЕЛТКЭАР С.А. (CH) Приоритет(ы): (30) Конвенционный приоритет: 04.03.2011 ...

Amine-containing compound analysis methods

The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.

Coloured compound containing a cationic group and a reactive group

A coloured compound containing a cationic group and a cellulose reactive group, especially a compound of the formula: or wherein A is the cationic group; Y is a chromophore; Y' is a cationic chromophore and B is the reactive group, which is suitable for the preparation of a protein absorbent or precipitant for use in the separation of mixtures of proteins.

Loc having usb device driver for use in a test module to control usb connection

A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having a universal serial bus (USB) device driver for operative control of a USB plug in the test module for communication with the external device.

A method and system for sampling and determining the presence of salts of ammonia and amines in containers

本发明公开了一种改进的方法和系统用以向容器中注入液体并检测容器中是否存在某些物质(例如玻璃或塑料瓶中潜在的污染物：铵盐或胺盐)。本发明还提供了用以检测瓶中的这些污染物的高速系统和方法。氨和胺能够通过在高速检测过程中从瓶子中发射出的化学发光来检测。将Na 2 CO 3 溶液注入瓶子中以便促进铵或胺盐向随后以气体形式释放出的游离氨或胺的转换。这就加强了诸如利用化学发光技术的气相检测系统检测是否存在铵盐或胺盐污染物的可能性。

METHOD AND APPARATUS FOR CONTINUOUS HIGH-SPEED ANALYSIS OF A LIQUID TEST IN A BEARING FLOW

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Test module with laser for excitation of oligonucleoutide probes

A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization with a target nucleic acid sequence to form probe-target hybrids, the probe-target hybrids being configured to generate a fluorescence signal in response to an excitation light, a laser positioned in the outer casing for generating the excitation light.

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Combined sensitivity-determining marker for anticancer agent

本发明提供一种能够判别各个患者的治疗反应性的抗癌剂感受性判定标记和利用其的新的癌症治疗方法。抗癌剂感受性判定标记的测定试剂在制造用于判定抗癌剂感受性的试剂盒中的用途，所述抗癌剂包含奥沙利铂或其盐和氟尿嘧啶或其盐，所述抗癌剂感受性判定标记为选自半胱氨酸‑谷胱甘肽、2‑氨基己二酸和鸟苷中的一种以上的分子。

pH and amine test to diagnosis of vaginal infections

Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.

PH and amine test elements

Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.

Combined optoelectrochemical sensor of nitrogen oxides in gaseous samples

FIELD: measurement equipment. SUBSTANCE: scope of application: for chemical sensors. Essence of the invention consists in the fact that a sensor for detection of nitrogen oxides includes a substrate including a porous membrane, a compound of aromatic amines, a gas passage system, an optic detection system for receiving the transmitted light from the compound of aromatic amines for detection of optical changes in the compound of aromatic amines; with that, the compound of aromatic amines includes a compound chosen from a group consisting of aromatic monoamines, derivatives of aromatic monoamines and 1,2-diaminobenzene. EFFECT: providing a possibility of improving reliability of nitrogen oxide detection. 39 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 27/30 (13) 2 549 912 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2011149232/28, 02.06.2010 (24) Дата начала отсчета срока действия патента: 02.06.2010 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 20.07.2013 Бюл. № 20 (73) Патентообладатель(и): АРИЗОНА БОРД ОФ РИДЖЕНТС ЭКТИНГ ФОР ЭНД ОН БИХАФ ОФ АРИЗОНА СТЕЙТ ЮНИВЕРСИТИ (US) R U 05.06.2009 US 61/184,596 (72) Автор(ы): ТАО Нунцзянь (US), ФОРСАНИ Эрика (US), ИГЛЕСИАС Родриго (US) (45) Опубликовано: 10.05.2015 Бюл. № 13 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 10.01.2012 C 2 C 2 6362005 B1, 26.05.2002. US 2008/0231849 A1, 25.09.2008. US 2006/0036138 A1, 16.02.2006. US 2007/0086920 А1, 19.04.2007. US 2003/0040120 А1, 27.02.2003. US 2008/0220984 A1, 11.09.2008. US 2005/0034985 A1, 17.02.2005. US 5958214, 28.09.1999 (86) Заявка PCT: US 2010/037101 (02.06.2010) 2 5 4 9 9 1 2 (87) Публикация заявки PCT: R U 2 5 4 9 9 1 2 (56) Список документов, цитированных в отчете о поиске: US 2008/0221806 A1, 11.09.2008. US WO 2010/141610 (09.12.2010) Адрес для переписки: 129090, Москва, ул. Большая Спасская, д. 25, строение 3, "Городисский и партнеры" (54) ...

ANALYSIS OF DOPING COMPOUNDS

1. Способ определения лекарственного препарата или лекарственного средства, или их метаболитов в биологической жидкости или экстракте из биологической ткани, или биологического образца, включающий приготовление образца, включающее этапы: ! (i) контактирование, по крайней мере, первой части жидкости или экстракта, по крайней мере, с одной первой твердой фазой, способной адсорбировать или абсорбировать органические соединения из жидкости или экстракта, ! (ii) контактирование, по крайней мере, второй части жидкости или экстракта, по крайней мере, с одной второй фазой, способной экстрагировать или адсорбировать органические соединения из жидкости или экстракта, ! (iii) при необходимости контактирование, по крайней мере, третьей части жидкости или экстракта с жидкой фазой, способной экстрагировать органические соединения из жидкости или экстракта, ! (iv) десорбция соединения(ий), связанного с первой твердой фазой, путем нагревания твердой фазы, и/или путем экстракции растворителем, при необходимости, с последующим испарением растворителя, по крайней мере, частично, ! (v) экстракция или десорбция соединения(ий), содержащегося во второй фазе или связанного с ней, путем нагревания и/или путем экстракции растворителем, при необходимости, с последующим, по крайней мере, частичным испарением растворителя, ! и последующий анализ десорбированных соединений из этапов (iv) и (v) при необходимости соединений, экстрагированных на этапе (iii), посредством многомерной газовой хроматографии (ГХ), предпочтительно путем комплексной многомерной ГХ (ГХ*ГХ), сочетающейся предпочтительно с масс-спектрометрией, путем введения десорбированных РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2010 105 043 (13) A (51) МПК G01N 33/50 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2010105043/15, 11.07.2008 (71) Заявитель(и): ДСМ АйПи АССЕТС Б.В. (NL) Приоритет(ы): (30) Конвенционный приоритет: 13.07.2007 EP 07013740.1 R U (54) ...

Electrochemical determination of fructosamine

The present invention relates to a method for electrochemically measuring the concentration of fructosamine, or its high alkalinity eneaminol tautomer in a body fluid sample.

METHOD OF MEASURING NOx IN LIQUIDS

Изобретение относится к способу измерения NО х в жидкости, в котором выделяют жидкую пробу, регулируют рН и/или ионную силу указанной пробы во время t 0 , регистрируют значение mV, присутствующее в указанной пробе, с помощью избирательного зонда NO х в заранее определенное время t 1 , регистрируют еще одно значение mV 2 , присутствующее в указанной пробе, по истечении еще одного заранее определенного времени t 2 , определяют концентрации NO х в указанной пробе в каждом заранее определенном интервале времени t 1 и t 2 , определяют изменения NO х , и определяют концентрацию NO х . Достигается упрощение способа и расширение возможностей его применения. 2 з.п.ф-лы, 3 ил. Р9сСбтсССсс ПЧ сэ (19) РОССИЙСКОЕ — АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВЦ 2 224 251 (51) МПК? (13) С2 С 01 М 33/18, С 02 Е 3/00 12 ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 2001118847/04 , 07.05.1999 (24) Дата начала действия патента: 07.05.1999 (30) Приоритет: 07.12.1998 0$ 09/206,543 (43) Дата публикации заявки: 10.07.2003 (46) Дата публикации: 20.02.2004 (56) Ссылки: Ч$ 5403488, 04.04.1995. 1$ 3854877 А, 17.12.1974. ЕР 0732588 А2, 14.03.1996. ОЕ 4224901 АТ, 03.02.1994. УР 5411829 А, 13.09.1979. О[ОЕ 03229960 АЛ, 16.02.1984. СВ 2139610 А, 14.11.1984. ЛУРЬЕ Ю.Ю. Аналитическая химия промышленных сточных вод. - М.: Химия, 1984, с.188-189. (85) Дата перевода заявки РСТ на национальную фазу: 09.07.2001 (86) Заявка РСТ: 1$ 99/10120 (07.05.1999) (87) Публикация РСТ: \УМ!О 00/34773 (15.06.2000) (98) Адрес для переписки: 129010, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", Ю.Д.Кузнецову, рег.№ 595 (72) Изобретатель: ЛИ Дзау Фанг (ЦЗ), МАНЕШИН Сергей К. (4$), КОЛБ Маркус Е. (4$), ЯНГ Ксин (9$) (73) Патентообладатель: БАИОКЕМ ТЕКНОЛОДЖИ, ИНК. (45$) (74) Патентный поверенный: Кузнецов Юрий Дмитриевич (54) СПОСОБ ИЗМЕРЕНИЯ МО, В ЖИДКОСТИ (57) Изобретение относится к способу измерения МО ‚„ в жидкости, в котором выделяют жидкую пробу, ...

Genetic analysis loc with hybridization array with negative control chambers incorporating probes with no reporters

A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a control probe with no fluorophore such that the control probe never emits the fluorescence signal in response to the excitation light.

Abuse resistant amphetamine compounds

본 발명은 암페타민에 공유 부착된 화학 잔기를 포함하는 화합물, 조성물 및 이들의 사용 방법에 관한 것이다. 이들 화합물 및 조성물은 암페타민의 남용 및 과잉투여를 감소 또는 예방하는데 유용하다. 이들 화합물 및 조성물은 특정 질병들, 예를 들어 주의력결핍 과다활동장애(ADHD), ADD, 기면증 및 비만증의 남용-방지성 대체 치료법을 제공하는데 있어서 특정 용도를 갖는다. 암페타민의 경구 생체이용률은 치료학상 유용한 투여량에서 유지된다. 더 많은 투여량에서, 생체이용률은 실질적으로 감소되어 경구 남용 가능성의 감소 방법이 제공된다. 또한, 본 발명의 화합물 및 조성물은 비경구 경로, 예를 들어 정맥내 또는 비강내 투여에 의한 암페타민의 생체이용률을 감소시킴으로써, 이들의 남용 가능성을 추가로 제한한다. The present invention relates to compounds, compositions comprising chemical moieties covalently attached to amphetamines and methods of using them. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions have particular uses in providing abuse-prophylactic alternative therapies for certain diseases, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher dosages, bioavailability is substantially reduced to provide a method of reducing the likelihood of oral abuse. In addition, the compounds and compositions of the present invention further limit their abuse potential by reducing the bioavailability of amphetamine by parenteral routes such as intravenous or intranasal administration. 암페타민, 화학 잔기, 남용 방지, 다행증, 주의력결핍 과다활동장애, 기면증, 비만증 Amphetamines, chemical residues, abuse prevention, good fortune, attention deficit hyperactivity disorder, narcolepsy, obesity

Multilayer analytical element

IMPROVED MULTILAYER ANALYTICAL ELEMENT Abstract of the Disclosure An analytical element for assay of complex fluids such as blood, the element comprising two layers each including at least one reagent, and a barrier composition separating the active constituents of the reagent layers. Such an element is particularly useful in the analysis of blood for urea nitrogen and cholesterol content.

ANALYSIS KIT COMPRISING AT LEAST TWO MOLECULAR IMPRESSION POLYMERS AND AT LEAST ONE MARKER, AND THE METHOD OF ANALYSIS USING THE SAME

La présente invention concerne un kit d'analyse d'au moins une molécule cible comprenant au moins un premier et un deuxième polymères à empreintes moléculaires chimiquement identiques ou différents, aptes à interagir avec la (ou les) molécule(s) cible(s), et au moins un marqueur, ledit marqueur étant apte (i) à interagir avec tout ou partie des sites de reconnaissance de la (ou des) molécule(s) cible(s) du deuxième polymère à empreintes moléculaires et (ii) à être déplacé du (ou des)dit(s) site(s) de reconnaissance par la (ou les) molécule(s) cible(s) lors de la mise en présence dudit deuxième polymère à empreintes moléculaires avec la (ou les)dite(s) molécule(s) cible(s). The present invention relates to a kit for analyzing at least one target molecule comprising at least a first and a second chemically identical or different molecular imprinted polymer capable of interacting with the target molecule (s). , and at least one marker, said marker being able (i) to interact with all or part of the recognition sites of the target molecule (s) of the second molecular-fingerprint polymer and (ii) to be displaced from said recognition site (s) by the target molecule (s) when said second molecular-fingerprint polymer is brought into contact with the said (or the) said molecule (s). s) target molecule (s).

Method and device for high sensitivity detection of the presence of dna and other probes

NITRIDES AND OXYNITRIDES USEFUL AS SELECTIVE DETECTORS OF REDUCING GASES IN THE ATMOSPHERE, AND DETECTION DEVICE CONTAINING THEM

Secretion-testing article

The present invention teaches pH indicator polymer matrices and methods of using same for identifying vaginal secretions. A secretion-monitoring article for the identification of secreted biological fluids is disclosed having a substrate for absorbing a biological fluid secreted from a person, and biocompatible pH indicator polymer matrices comprising at least one pH determining reagent that reacts with biological fluids that have low buffer capacity differently than with bodily fluids that have normal buffer capacity.

Diagnostic agent for the detection of copulable constituents of fluids contained in the body

Aquatic environment water-quality monitor having a submersible chemical indicator wheel

A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities.

Abuse resistant lysine amphetamine compounds

The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

Method and system for sampling and determining the presence of salts of ammonia and amines in containers

Agent and process for the determination of redox systems

Die Erfindung betrifft neue Mittel und ihre Verwendung zum Nachweis von Redox-Systemen durch oxidative Kupplung (Trinder-Reaktion), die Anilinderivate der Formel I als Farbbilder enthalten <IMAGE> in der R1 Wasserstoff, Niederalkyl und Aryl sein kann, R2 für Wasserstoff, Niederalkyl, das durch Hydroxy-, Amino-, Carboxy-, Niederalkoxycarbonyl-, Niederalkanoylamidogrupen, Arylniederalkyl und Aryl und Gruppen der Struktur <IMAGE> in denen R5 und R6 die unten angegebene Bedeutung haben, substituiert sein kann, steht, R3 Wasserstoff, Carboxy oder Halogen sein kann, R4 und R4' für Wasserstoff, Halogen, Carboxy-, Niederalkoxy- oder eine bevorzugt in m-Stellung stehende Niederalkylgruppe steht und R1 und R2 bzw. R2 und R4 bzw. R4 und R4, für den Fall, daß die beiden Substituenten orthoständig zueinander stehen, zusammen eine gesättigte oder ungesättigte Kohlenwasserstoffkette mit 2-6 C-Atomen bilden können, die durch Hydroxy- oder Oxogruppen substituiert sein kann, R5 Wasserstoff oder eine Niederalkylgruppe sein kann und R6 eine Hydroxy-, eine Niederalkoxy, eine Niederalkyl- oder Arylgruppe ist, sowie ihre Salze mit Säuren oder Basen, sowie neue Anilinderivate der Formel I' und Verfahren zu ihrer Herstellung, The invention relates to new agents and their use for the detection of redox systems by oxidative coupling (Trinder reaction), which contain aniline derivatives of the formula I as color images <IMAGE> in which R1 can be hydrogen, lower alkyl and aryl, R2 for hydrogen, lower alkyl , which can be substituted by hydroxyl, amino, carboxy, lower alkoxycarbonyl, lower alkanoylamido groups, aryl-lower alkyl and aryl and groups of the structure <IMAGE> in which R5 and R6 have the meaning given below, R3 is hydrogen, carboxy or halogen can be, R4 and R4 'represents hydrogen, halogen, carboxy, lower alkoxy or a preferably lower alkyl group and R1 and R2 or R2 and R4 or R4 and R4, in the event that the two substituents are ortho to each other, ...

MULTIFUNCTIONAL DETECTOR OF GASEOUS COMPOUNDS AND APPLICATIONS THEREOF

Détecteur multifonctionnel de composés gazeux ou mélanges de composés gazeux choisis parmi NH CI, NHCl , NCI chlore total, NOx où x=1 ou 2, O et X où X=Cl, Br ou I dans un échantillon, ledit détecteur comprenant un premier capteur comprenant un iodure et un composé réactif choisi parmi l'amidon, l'amylose, l'amylopectine, le xyloglucane, le xylane, le chitosane, le glycogène, l'alcool polyvinylique ou un composé de l'alcool polyvinylique, la cellulose ou un composé de la cellulose, l'a-cyclodextrine, la théobromine et les polymères blocs d'oxydes de polypropylène et de polyéthylène, incorporés dans un bloc de matériau sol-gel absorbant dans l'UV mais pas dans le visible, et ses applications. Multifunctional detector for gaseous compounds or mixtures of gaseous compounds selected from NH CI, NHCl, NCI total chlorine, NOx where x = 1 or 2, O and X where X = Cl, Br or I in a sample, said detector comprising a first sensor comprising an iodide and a reactive compound selected from starch, amylose, amylopectin, xyloglucan, xylan, chitosan, glycogen, polyvinyl alcohol or a polyvinyl alcohol compound, cellulose or a composed of cellulose, α-cyclodextrin, theobromine and block polymers of polypropylene and polyethylene oxides, incorporated in a block of sol-gel material absorbing in the UV but not in the visible, and its applications.

Water-quality monitoring system

Abuse-resistant amphetamine prodrugs

The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

METHOD OF MEASURING NITRIFICATION RATES IN BIOCHEMICAL PROCESSES