28-04-1997 дата публикации
Номер: JP0009110858A
Принадлежит:
PROBLEM TO BE SOLVED: To obtain a new compound useful as a medicine acting on dopamine- working systems and as a psychosis therapeutic medicine. SOLUTION: This racemic or optically active tertiary heterocyclic amine is expressed by formula I [-A-D-E is a carbonylalkyl, etc.; X is an alkyl, etc.; (n) is 0, 1; Y is an alkyl, etc.; Z is an alkyl, an alkenyl, etc.], or its acid adduct, e.g. (7RS)-7-(N,N-dipropylamino)-2,3,5,6,7,8-hexahydronaphtho[2,3-b]thiophene. The compound of formula I is obtained by reacting a secondary amine of formula II [-A'-D-E is -(CH2)3-, -S-(CH2)2-, -S-CH=CH-, etc.], with a compound of the formula: G-Y-Z (G is a halogen, methyloxy, etc.), and subsequently oxidizing the reaction product. The compound is useful for the therapy of Parkinson's disease, dysmnesia, disorders accompanied by drug abuse, depression, etc. The active ingredient is orally, rectally or parenterally at a dose of 0.5-25mg once to twice a day. COPYRIGHT: (C)1997,JPO ...
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