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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 4. Отображено 4.
15-01-2015 дата публикации

P2X4 RECEPTOR ANTAGONIST

Номер: WO2015005467A1
Автор: SAKUMA, Shogo, KOBAYASHI, Kunio, USHIODA, Masatoshi, IMAI, Toshiyasu, INOUE, Kazuhide
Принадлежит:

The present invention relates to a compound represented by general formula (I) having a P2X4 receptor antagonist action. (I) (In the formula, R1, R2 and R3 are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, etc., X is C or N, and Y is N or C (=O), provided that when X is C, Y is N, and when X is N, Y is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, n is an integer of 0 to 6, Z is O, S or a bond, and A is a benzene ring, a pyridine ring, etc.) ...

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Номер записи: 1
29-11-2012 дата публикации

PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEUROPATHIC PAIN ASSOCIATED WITH GUILLAIN-BARRE SYNDROME

Номер: WO2012161301A1
Автор: IMAI, Toshiyasu, KAWASAKI, Toru, OGAWA, Toru, INOUE, Kazuhide
Принадлежит:

A P2X4 receptor antagonist such as paroxetine and a diazepinedione derivative represented by general formula (IX) is used as a prophylactic or therapeutic agent for neuropathic pain associated with Guillain-Barre syndrome. (In the formula, R1 represents a hydrogen atom, an alkyl group having 1-8 carbon atoms, or the like; R2 and R3 independently represent a hydrogen atom, an alkyl group having 1-8 carbon atoms, or the like; R4 and R5 independently represent a hydrogen atom, or the like; and W represents a 5- or 6-membered heterocyclic ring which contains 1-4 nitrogen atoms as ring-constituting elements and which may have a substituent.) ...

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Номер записи: 2
18-07-2013 дата публикации

P2X4 RECEPTOR ANTAGONIST

Номер: WO2013105608A1
Автор: USHIODA, Masatoshi, KOBAYASHI, Kunio, SAITO, Daisuke, SAKUMA, Shogo, IMAI, Toshiyasu, INOUE, Kazuhide
Принадлежит:

The present invention relates to a diazepine derivative represented by general formula (I) (In the formula: R1 and R2 are a hydrogen atom, etc. or R1 and R2 together with a benzene ring to which they are attached are a naphthalene ring, etc.; R3 and R4 are a hydrogen atom, etc.; R5 is a hydrogen atom, etc.; R6 and R7 are a hydrogen atom, etc.; X is C, CH or N and Y is N, NH or C (=O), provided that when X is N, Y is not N or NH and when X is C or CH, Y is not C (=O); Z is an oxygen atom or a sulfur atom; A is a benzene ring, etc.; B is NHC (=O), etc.; D is an atomic bonding, etc.; E is an atomic bonding, etc.; G is benzene which may by substituted, etc.; and m is an integer of 0 to 5.) or a pharmaceutically acceptable salt thereof, and a P2X4 receptor antagonist.

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Номер записи: 3
15-01-2015 дата публикации

P2X4 RECEPTOR ANTAGONIST

Номер: WO2015005468A1
Автор: SAKUMA, Shogo, KOBAYASHI, Kunio, USHIODA, Masatoshi, SAITO, Daisuke, IMAI, Toshiyasu, INOUE, Kazuhide
Принадлежит:

The present invention relates to a compound represented by general formula (II) having a P2X4 receptor antagonist action. (II) (In the formula, R1a to R6a are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, etc., Xa is C or N, and Ya is N or C (=O), provided that when Xa is C, Ya is N, and when Xa is N, Ya is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, Aa is a benzene ring, a pyridine ring, etc., Da is a tetrazole ring, an imidazole ring, etc., Ea is -(CR9aR10a)p-Ta-, and Ga is a benzene ring, a pyridine ring, etc.) ...

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Номер записи: 4