Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 7. Отображено 7.
05-07-2018 дата публикации

BENZO[B]THIOPHENE AMIDE DERIVATIVE AND USE THEREOF

Номер: WO2018121607A1
Автор: SONG, Chun, ZHANG, Chengcheng, HUANG, Niu, ZHANG, Chengzhi, ZHAO, Xin, ZHANG, Heng
Принадлежит:

Disclosed are a benzo[b]thiophene amide derivative and the use thereof. In particular, the present invention relates to a benzo[b]thiophene amide derivative having a structure of formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compounds in regulating the activity of the Smoothened receptor or Hedgehog pathway.

Подробнее
Номер записи: 1
05-07-2018 дата публикации

HEDGEHOG PATHWAY INHIBITOR FOR SMOOTHENED MUTANT STRAIN

Номер: WO2018121610A1
Автор: SONG, Chun, ZHANG, Chengcheng, HUANG, Niu, ZHANG, Chengzhi, ZHAO, Xin, ZHANG, Heng
Принадлежит:

Provided are a compound as shown in general formula I, a pharmaceutically acceptable salt, an isomer and a solvate thereof, or a compound obtained through the substitution of any atom in the compound of formula I with an isotope thereof, and the use of the compound.

Подробнее
Номер записи: 2
01-09-2011 дата публикации

PEGYLATED CYCLOPAMINE ANALOGUE, PREPARATION METHOD AND USES THEREOF

Номер: WO2011103773A1
Автор: SONG, Chun, ZHANG, Chengzhi, ZHAO, Xin, HU, Zhao, XU, Xiuling, ZHANG, Youzhong, WANG, Mingyi, SUN, Zhijun
Принадлежит:

A PEGylated cyclopamine analogue, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analogue is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.

Подробнее
Номер записи: 3
11-07-2023 дата публикации

Application of active molecule for regulating and controlling HIF-3alpha in treatment of diseases

Номер: CN116407635A
Автор: WU DALEI, SONG CHUN, ZHANG CHENGCHENG, ZHUANG JINGJING, DIAO XIAOTONG
Принадлежит:

The invention provides an application of an active molecule for regulating and controlling HIF-3alpha in treating diseases. Specifically, the invention provides an application of an active molecule and/or a pharmaceutical composition for regulating and controlling HIF-3alpha in preparation of drugs (such as antiviral drugs) for treating diseases. The invention discloses an application of oleoyl ethanolamine (OEA) as an endogenous ligand of a hypoxia-inducible factor (HIF)-3alpha, and the application of the oleoyl ethanolamine (OEA) as the endogenous ligand of the hypoxia-inducible factor (HIF)-3alpha. The OEA can be directly combined with the HIF-3alpha and activate transcription and translation of the HIF-3alpha, and the overexpression of the HIF-3alpha can activate signal channels for resisting measles viruses, influenza A viruses and the like. The new application of the HIF-3alpha regulator (such as an agonist) found by the invention has important significance on biology, especially ...

Подробнее
Номер записи: 4
15-06-2016 дата публикации

Prevent drawing hand ampoule bottle opener

Номер: CN0205313036U
Автор: ZHANG JING, SONG CHUN, LI WEIZHI
Принадлежит:

... 本实用新型涉及一种防划手安瓿开瓶器，包括塑料保护套、连接绳、砂轮和拉扣，所述塑料保护套一端开口，另一端连接有连接绳，所述连接绳的另一端与拉扣连接，所述连接绳上套设有砂轮，砂轮与拉扣之间的连接绳上设有卡扣。本实用新型的安瓿开瓶器整体结构简单，便于携带，可帮助护理人员实现快速大量开瓶，并在护理人员掰开安瓿时有效防止划伤皮肤。 ...

Подробнее
Номер записи: 5
11-08-2023 дата публикации

Convenient supporting construction method for cover arch frame self-bearing formwork

Номер: CN116575457A
Автор: SONG CHUN, ZHAO JIANHUA, CHAO ZONGRONG, GUO XIUFENG, YANG XU, ZHANG LINFEI, LIANG WEI, TANG YONGHONG, LONG YINGBIN, CHEN HAO
Принадлежит:

The invention relates to a convenient support construction method for a cover arch frame self-bearing template, which comprises the following steps of: positioning and mounting a steel arch frame, namely splicing the steel arch frame, measuring and positioning, and welding a guide steel pipe; pouring a concrete foundation; a formwork and a water stop screw rod are welded; pouring concrete; and maintenance treatment. The steel arch frame of the cover arch is used as a supporting system for cover arch concrete construction, the bottom formwork, the steel arch frame, the cover arch concrete layer and the outer formwork are connected into a whole through the water stop screws, a stable supporting system is formed, the effect that one arch frame plays two roles is truly achieved, and compared with existing tunnel formwork supporting cover arch construction, the construction efficiency is greatly improved. The supporting system is used for construction, the construction condition range is widened ...

Подробнее
Номер записи: 6
01-08-2023 дата публикации

Small and medium section tunnel excavation method based on micro-step improvement

Номер: CN116517552A
Автор: ZHAO JIANHUA, YANG XU, LIANG WEI, QIU XIN, SONG SHIYIN, SONG CHUN, WANG LI, LONG YINGBIN, CAI ZHUN, CHEN HAO
Принадлежит:

The invention belongs to the technical field of building construction, and particularly discloses a small and medium section tunnel excavation method based on micro-step improvement, which comprises the following steps: excavating an upper step of a tunnel for 3-5m, brushing a slope of a lower step to form a ramp, and meeting the requirement that personnel and equipment enter an upper step area for construction operation; the left (right) half temporary supporting device is dismantled, and rock soil of the left (right) half part of the lower step is excavated through drilling and blasting or mechanical excavation according to the surrounding rock condition; primarily spraying the left (right) half edge, mounting two units of steel arches, anchor rods and reinforcing meshes, and spraying concrete to finish primary supporting; according to the scheme, the lower step of a traditional micro-step is excavated in a ramp mode, the height-variable steel arch temporary supporting device is adopted ...

Подробнее
Номер записи: 7