Crystallization preparation method of high-water-solubility chlortetracycline hydrochloride

The invention discloses a crystallization preparation method of high-water-solubility chlortetracycline hydrochloride, which specifically comprises the following steps: dissolving, filtering, washing, acidizing and crystallizing, and researching key parameters such as crystallization kinetics, crystallization thermodynamics and crystallization saturation curve theory of chlortetracycline hydrochloride in an extraction process to obtain the high-water-solubility chlortetracycline hydrochloride. According to the aureomycin hydrochloride extraction process, crystallization process conditions only need to be strictly controlled in the secondary crystallization process, the product content can be increased, the product solubility can be improved, the aureomycin content of an aureomycin hydrochloride product in the European pharmacopoeia detection standard (E.P method for short) can be larger than or equal to 92% and is far higher than the standard, larger than or equal to 89.5%, in the European ...