27-06-2023 дата публикации
Номер: CN116334151A
Принадлежит:
The invention provides a method for synthesizing dexketoprofen. Comprising the following steps: S1, with ketoprofen amide as a raw material, carrying out a hydrolysis reaction in a reaction medium, a cosolvent, a phase transfer catalyst and an amidase system, and carrying out separation and purification to obtain dexketoprofen and levorotatory ketoprofen amide; s2, performing chemical racemization reaction on the levorotatory ketoprofen amide in the presence of a solvent and alkali to obtain ketoprofen amide; and repeating the step S1 by taking ketoprofen amide as a raw material. The method disclosed by the invention has the advantages of high substrate concentration, low enzyme-substrate ratio, high selectivity, high conversion rate, high product purity, higher efficiency, low solvent dosage, lower cost, full utilization of raw materials, less solid waste discharge and good industrial application potential, and can meet the requirements of enzyme catalysis industrial production.
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