11-10-2012 дата публикации
Номер: US20120258170A1
A co-crystal composition comprised of Quercetin and at least one antidiabetic agent acts as a combination drug having unique physical properties and biological activity, which differ from both Quercetin in pure form and the at least one antidiabetic agent in pure form. The co-crystal composition may comprise quercetin and metformin. The co-crystals of quercetin and metformin may be prepared by grinding the compounds, and used in pharmaceutical compositions comprising these co-crystals. Co-crystal compositions of quercetin and Metformin may be used in combination with other anti-diabetic agents, including DPP-IV inhibitors. 1. A co-crystal composition comprising:a) Quercetin, a hydrate thereof, a polymorph thereof, a salt thereof, or mixtures thereof; andb) at least one anti-diabetic agent selected from the group consisting of DPP-IV inhibitors.2. The co-crystal composition as claimed in claim 1 , wherein the DPP-IV inhibitors are selected from the group consisting of sitagliptin claim 1 , vildagliptin claim 1 , dutogliptin claim 1 , saxagliptin claim 1 , linagliptin claim 1 , gemigliptin claim 1 , alogliptin and mixtures thereof.3. The co-crystal composition as claimed in claim 1 , wherein said co-crystal composition comprises a hydrate of quercetin or a polymorph of quercetin.4. A composition comprising: i) Quercetin, a hydrate thereof, a polymorph thereof, a salt thereof, or mixtures thereof; and', 'ii) at least one first anti-diabetic agent; and, 'a) a co-crystal comprisingb) a second anti-diabetic agent selected from the group consisting of biguanide drugs; sulfonylurea drugs; alpha-glucosidase inhibitors; thiazolidinedione drugs; DPP-IV inhibitors, and mixtures thereof.5. The co-crystal composition as claimed in claim 4 , wherein the co-crystal is in physical combination with said second anti-diabetic agent.6. The co-crystal composition as claimed in claim 5 , wherein said second anti-diabetic agent is selected from the group consisting of tolazamide claim 5 , ...
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