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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 2. Отображено 2.
24-05-2012 дата публикации

PHARMACEUTICAL CO-CRYSTALS OF QUERCETIN

Номер: US20120129923A1
Принадлежит: NUTRACRYST THERAPEUTICS PRIVATE LIMITED

Disclosed herein is synergistic pharmaceutical co-crystals composition comprising Quercetin and an antidiabetic agent(s) as combination drug that have unique physical properties and biological activity which differ from the active agent in pure form. The invention further discloses process for preparation of the same and pharmaceutical compositions comprising these synergistic co-crystals.

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11-10-2012 дата публикации

PHARMACEUTICAL CO-CRYSTALS OF QUERCETIN

Номер: US20120258170A1
Принадлежит: NUTRACRYST THERAPEUTICS PRIVATE LIMITED

A co-crystal composition comprised of Quercetin and at least one antidiabetic agent acts as a combination drug having unique physical properties and biological activity, which differ from both Quercetin in pure form and the at least one antidiabetic agent in pure form. The co-crystal composition may comprise quercetin and metformin. The co-crystals of quercetin and metformin may be prepared by grinding the compounds, and used in pharmaceutical compositions comprising these co-crystals. Co-crystal compositions of quercetin and Metformin may be used in combination with other anti-diabetic agents, including DPP-IV inhibitors. 1. A co-crystal composition comprising:a) Quercetin, a hydrate thereof, a polymorph thereof, a salt thereof, or mixtures thereof; andb) at least one anti-diabetic agent selected from the group consisting of DPP-IV inhibitors.2. The co-crystal composition as claimed in claim 1 , wherein the DPP-IV inhibitors are selected from the group consisting of sitagliptin claim 1 , vildagliptin claim 1 , dutogliptin claim 1 , saxagliptin claim 1 , linagliptin claim 1 , gemigliptin claim 1 , alogliptin and mixtures thereof.3. The co-crystal composition as claimed in claim 1 , wherein said co-crystal composition comprises a hydrate of quercetin or a polymorph of quercetin.4. A composition comprising: i) Quercetin, a hydrate thereof, a polymorph thereof, a salt thereof, or mixtures thereof; and', 'ii) at least one first anti-diabetic agent; and, 'a) a co-crystal comprisingb) a second anti-diabetic agent selected from the group consisting of biguanide drugs; sulfonylurea drugs; alpha-glucosidase inhibitors; thiazolidinedione drugs; DPP-IV inhibitors, and mixtures thereof.5. The co-crystal composition as claimed in claim 4 , wherein the co-crystal is in physical combination with said second anti-diabetic agent.6. The co-crystal composition as claimed in claim 5 , wherein said second anti-diabetic agent is selected from the group consisting of tolazamide claim 5 , ...

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