Device for Ion Sorting by M/Z

An RF voltage is applied across each electrode of a first array of evenly spaced, parallel, and coplanar electrodes and its corresponding electrode of a second array of evenly spaced, parallel, and coplanar electrodes. The RF voltage varies in amplitude according to an RF voltage amplitude gradient. The RF voltage produces an array of different quadrupole RF electric fields in a uniform gap between the first array and the second array. A DC voltage is superimposed on each electrode of the first array and its corresponding electrode of the second array. The DC voltage varies according to a DC voltage gradient in order to produce a DC electric field in the uniform gap. When ions are introduced in the uniform gap, the DC electric field causes the ions to drift toward quadrupole RF electric fields with increasing RF voltage amplitudes where the ions are trapped according to their m/z.

Power management system and power management method

A power management system is provided with a power supplying means, a measuring means for measuring the power generation environment for the power supplying means, and a communication means for transmitting information measured by the measuring means. The power management system is also provided with a control unit for controlling the measuring means and the communication means. The power supplying means is used as the power supply for the measuring means and the communication means. The control unit sets, on the basis of the amount of power to be supplied by the power supplying means, a first power threshold value to be used for evaluating whether or not to switch the operating state of the measuring means, and a second power threshold value to be used for evaluating whether or not to switch the operating state of the communication means.

Ion Sorter

A static magnetic field is applied in the same direction using a first magnet and a second magnet. The magnetic field is applied to a gap of uniform thickness between the first and second magnets. Voltages are applied to three or more electrodes located in the gap using a switchable voltage source. The voltages are applied to create a static electric field perpendicular to the static magnetic field in an input channel and at least one channel of two or more output channels. The channels are defined by gaps between the three or more electrodes. The simultaneous application of the static magnetic field and the static electric field causes ions from an ion beam of a mass spectrometer to move into and through the input channel and through at least one channel of the two or more output channels to another location in the mass spectrometer. 1. An ion sorter for directing an ion beam of mass spectrometer to one of two or more locations , comprising:a first magnet and a second magnet that each apply a static magnetic field in the same direction to a gap of uniform thickness between the first and second magnets; 'wherein gaps between the three or more electrodes define an input channel for accepting ions of an ion beam of a mass spectrometer and define two or more output channels branching from the input channel; and', 'three or more electrodes located in the gap,'}a switchable voltage source in electrical communication with the three or more electrodes that can apply voltages to the three or more electrodes to create a static electric field across the input channel and at least one channel of the two or more output channels that is perpendicular to the static magnetic field and that in conjunction with the static magnetic field causes the ions to move into and through the input channel and through at least one channel of the two or more output channels to another location in the mass spectrometer.2. The ion sorter of claim 1 , further comprising selects a channel of the two ...

BAND PASS EXTRACTION FROM AN ION TRAPPING DEVICE AND TOF MASS SPECTROMETER SENSITIVITY ENHANCEMENT

A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping AC voltage and a DC voltage. A radial dipole DC voltage is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to a lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. Alternatively, a radial RF trapping voltage amplitude is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. 1. A system for mass selectively extracting ions , comprising:a multipole rod set of an ion guide adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage;a lens electrode of the ion guide positioned at one end of the multipole rod set to extract ions trapped by the multipole rod set and adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage; anda processor in communication with the multipole rod set and the lens electrode that simultaneously applies a radial dipole DC voltage to the multipole rod set and an axial trapping AC voltage to the lens electrode or simultaneously applies a radial RF trapping voltage amplitude to the multipole rod set and an axial trapping AC voltage to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set.2. The system of claim 1 , further comprising a linear accelerator positioned coaxially with the multipole rod set to further accelerate ions trapped in the multipole rod set and to further accumulate ions near the lens electrode.3. The system of claim 1 , wherein the processor applies a DC voltage on the ...

Method of extracting ions with a low M/Z ratio from an ion trap

In a mass spectrometer, a method for trapping ions includes providing at least first and second multipole rod sets positioned in tandem, introducing a plurality of ions into the first rod set, applying an RF potential to at least one of said rod sets to generate a radial trapping potential within said rod sets, applying a radial DC potential to said first rod set so as to modulate said radial trapping potential set as a function of m/z of said ions, and applying a DC potential between said two rod sets to provide an axial bias potential between said two rod sets. The method can further comprise selecting an axial barrier potential to selectively extract ions having an m/z ratio less than a threshold from said first rod set into said second rod set.

Light detection device

A semiconductor light detection element has a plurality of channels, each of which consists of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode, quenching resistors connected in series to the respective avalanche photodiodes, and signal lines to which the quenching resistors are connected in parallel. A mounting substrate is configured so that a plurality of electrodes corresponding to the respective channels are arranged on a third principal surface side and so that a signal processing unit for processing output signals from the respective channels is arranged on a fourth principal surface side. In a semiconductor substrate, through-hole electrodes electrically connected to the signal lines are formed for the respective channels. The through-hole electrodes and the electrodes are electrically connected through bump electrodes.

Light detection device

A semiconductor light detection element has a plurality of channels, each of which consists of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode, quenching resistors connected in series to the respective avalanche photodiodes, and signal lines to which the quenching resistors are connected in parallel. A mounting substrate is configured so that a plurality of electrodes corresponding to the respective channels are arranged on a third principal surface side and so that a signal processing unit for processing output signals from the respective channels is arranged on a fourth principal surface side. In a semiconductor substrate, through-hole electrodes electrically connected to the signal lines are formed for the respective channels. The through-hole electrodes and the electrodes are electrically connected through bump electrodes.

Simultaneous positive and negative ion accumulation in an ion trap for mass spectroscopy

A mass spectrometer ion reaction device, useful for performing ion-ion reactions (eg. ETD, PTR) is described. The device includes a plurality of non-linear rods, that form a pair of quadrupole rod sets. The device includes an axial passageway, that allows injections of ions of both polarities into the device, and a three dimensional trapping region. Anions and cations that are injected into the device are spatially separated into different trapping regions by a DC dipole electric field generated by a DC voltage source. The device also includes a plurality of lenses to confine, transmit or receive ions in/from the device.

Multiplexed Precursor Isolation for Mass Spectrometry

Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected. N groups of the N precursor ions are created. The tandem mass spectrometer is instructed to perform multiplexed precursor ion selection on the continuous beam of ions, fragment each of the N− precursor ions, and measure the intensities of the product ions, producing N product ion spectra. A heat map is plotted, producing N heat maps. The N product ion spectra are combined into a combined product ion spectrum. A corresponding precursor ion of a peak is identified by finding a heat map of the N heat maps that does not have data for the mass of the peak and determining that a precursor ion of the N precursor ions that is not included in a group that produced the heat map is the corresponding precursor ion. 1. A system for identifying precursor ions of product ions from combined product ion spectra produced by a tandem mass spectrometer that performs multiplexed precursor ion selection , comprising:an ion source that provides a continuous beam of ions;a tandem mass spectrometer that includes a mass filter that performs multiplexed precursor ion selection; and creates N groups of the N precursor ions, wherein each of the N groups has N−1 precursor ions of the N precursor ions and wherein a different precursor ion of the N precursor ions is not included in each of the N groups,', 'instructs the tandem mass spectrometer to perform multiplexed precursor ion selection on the continuous beam of ions for each of the N groups, fragment each of the N−1 precursor ions selected in each of the N groups, and measure the intensities of the product ions produced by each of the N groups, producing N product ion spectra,', 'plots a heat map for each of the N product ion spectra, producing N heat maps,', 'combines the N product ion spectra into a combined product ion spectrum, and', 'identifies a corresponding precursor ion of a peak in the ...

Methods For Analysis of Lipids Using Mass Spectrometry

A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules. 1. A method for analyzing a sample containing or suspected of containing at least one lipid using a mass spectrometer , the method comprising:ionizing the sample to form a plurality of parent ions;performing an electron dissociation reaction to fragment at least a portion of the plurality of parent ions into a plurality of daughter ions, the electron dissociation reaction comprising irradiating the plurality of parent ions with a charged species; wherein the dissociation reaction is configured to allow distinguishing mass signatures of two isomeric species of said at least one lipid; anddetecting at least a portion of the plurality of daughter ions at a detector of the mass spectrometer to form at least one spectrum for mass analysis of the sample.2. A method for analyzing a sample containing or suspected of containing at least one lipid using a mass spectrometer , the method comprising:ionizing the sample to form a plurality of singly-charged precursor ion species;performing an ion-electron reaction to fragment at least a portion of the plurality of precursor ion species into a plurality of ...

SIMULTANEOUS POSITIVE AND NEGATIVE ION ACCUMULATION IN AN ION TRAP FOR MASS SPECTROSCOPY

An ion reaction device is provided having an ion injection inlet for receiving a plurality of ions and an ion ejection outlet through which ions can exit the device. The reaction device includes a plurality of non-linear rods disposed relative to one another so as to provide an axial region configured to receive a plurality of anions and cations via said ion injection inlet, and a plurality of trapping regions in communication with the axial region in which said anions and cations can be confined. A DC voltage source is adapted to apply a DC voltage across at least two of said rods so as to generate an electric field within at least a portion of said axial region for spatially separating the received anions and cations and guiding the anions into one of said trapping regions and the cations into another one of said trapping regions. 1. An ion reaction device , comprising:an ion injection inlet for receiving a plurality of ions and an ion ejection outlet through which ions can exit the device,a plurality of non-linear rods disposed relative to one another so as to provide an axial region configured to receive a plurality of anions and cations via said ion injection inlet, and a plurality of trapping regions in communication with the axial region in which said anions and cations can be confined, anda DC voltage source adapted to apply a DC voltage across at least two of said rods so as to generate an electric field within at least a portion of said axial region for spatially separating the received anions and cations and guiding said anions into one of said trapping regions and the cations into another one of said trapping regions.2. The ion reaction device of claim 1 , wherein said non-linear rods are L-shaped rods.3. The ion reaction device of claim 2 , wherein said L-shaped rods comprise a pair of quadrupole rod sets.4. The ion reaction device of claim 1 , wherein said rod sets are stacked relative to one another so as that each rod in one set is disposed below a ...

Power management system and power management method

A power management system has power supplying means, measuring means that measures power generation environment for the power supplying means, and communication means that transmits information measured by the measuring means. The power management system comprises: a control unit that controls the measuring means and the communication means. The power supplying means is used as a power source for the measuring means and the communication means. The control unit sets a first power threshold to be used for determining whether or not to switch operation states of the measuring means and a second power threshold to be used for determining whether or not to switch operation states of the communication means on the basis of a power supply that is supplied from the power supplying means.

Ion Guide for Mass Spectrometry

Methods and systems for transmitting ions in an ion guide are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can cause at least a portion of ions entrained in a gas flow entering an ion guide to be extracted from the gas jet and be guided downstream along one or more path of gas flow, where the gas lacking the ions can be removed from the ion guide. In some embodiments, the ions extracted from the gas stream can be guided into a focusing region in which the ions can be focused, e.g., via RF focusing, to enter into subsequence processing stages, such as a mass analyzer. 1. An ion guide , comprising:an enclosure comprising at least two opposed sidewalls extending longitudinally along a central axis from a proximal inlet end to a distal outlet end, the proximal inlet end being configured to receive a plurality of ions entrained in a gas flow through an inlet orifice disposed on the central axis; andan obstruction disposed within said enclosure between the proximal and distal ends, said obstruction deflecting at least a portion of the gas flow away from said central axis of the enclosure,wherein each of said opposed sidewalls comprises a plurality of electrodes to which RF and DC electric voltages are applied so as to generate an electric field for deflecting said entrained ions away from the central axis of the enclosure proximal to said obstruction and at least one electrode to which a RF electric potential is applied for focusing said deflected ions toward the central axis distal to said obstruction.2. The ion guide of claim 1 , wherein at least one of the opposed sidewalls defines a window through which at least a portion of the gas flow can exit the enclosure.3. The ion guide of claim 1 , wherein the enclosure is further defined by opposed wall electrodes disposed between the opposed sidewalls and wherein the opposed wall electrodes are offset relative to said central axis such that they are outside the gas ...

Light detection device including a semiconductor light detection element, a mounting substrate, and quenching circuits wherein the first electrodes of the light detection element corresponding to the second electrodes of the mounting substrate are electrically connected through bump electrodes

A light detection device 1 has a semiconductor light detection element having a semiconductor substrate, and a mounting substrate arranged as opposed to the semiconductor light detection element. The semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and electrodes electrically connected to the respective avalanche photodiodes and arranged on a second principal surface side of the semiconductor substrate. The mounting substrate includes a plurality of electrodes arranged corresponding to the respective electrodes on a third principal surface side, and quenching resistors electrically connected to the respective electrodes and arranged on the third principal surface side. The electrodes and the electrodes are connected through bump electrodes.

Light detection device including a semiconductor light detection element with a through-hole electrode connection, a mounting substrate and a light-transmissive substrate

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through bump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other.

Exhaust gas component purification catalytic material and catalyzed particulate filter with the catalytic material

An exhaust gas component purification catalytic material 1 for use in removal of particulates in an exhaust gas through combustion includes: composite oxide particles 2 containing zirconium and neodymium and not containing cerium; and praseodymium oxide particles 3 in contact with the composite oxide particles 2.

Exhaust gas purifying catalyst, method for producing same, and exhaust gas purification method using same

An exhaust gas purify catalyst includes a substrate (1), an oxidation catalyst layer (2) formed on the substrate (1) and containing zeolite and at least one catalytic metal, an LNT layer (3) formed on the oxidation catalyst layer (2) and containing an NOx storage material and at least one catalytic metal, and an NOx reduction layer (4) formed on the LNT layer (3) and containing Rh acting as a catalytic metal and at least one of alumina or zirconia, wherein the NOx reduction layer (4) has a larger content of Rh than that in each of the oxidation catalyst layer (2) and the LNT layer (3).

Light detection device including a semiconductor light detection element, and a semiconductor light detection element having a through-hole electrode connection

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through bump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other.

Exhaust gas purification catalyst and production method thereof

This catalyst includes a lower catalytic layer 2 having catalytic ability to oxidize HC and CO and an upper catalytic layer 3 having catalytic ability to reduce NOx. The lower catalytic layer 2 contains Pt and Pd acting as catalytic metals, zeolite, a Ce-containing oxide, and activated alumina, and the upper catalytic layer 3 contains activated alumina loading an Rh-doped Ce-containing oxide and an NOx storage material.

Light detection device having a semiconductor light detection element, a mounting substrate, a glass substrate and a plurality of through-hole electrodes electrically connected to quenching resistors

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through bump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other.

Exhaust gas purification catalyst and method for manufacturing same

An exhaust gas purification catalyst is disposed in an exhaust gas channel of an engine and includes a catalytic layer 22 provided on a substrate 21 . The catalytic layer 22 contains multiple types of γ-aluminas 23 and 24 which are different in composition and Pt 25 loaded on the multiple types of γ-aluminas 23 and 24.

Multiplexed Precursor Isolation for Mass Spectrometry

Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions. Two or more different precursor ions are selected by applying two or more different AC voltage frequencies to rods of a selection region in order to resonate the two or more different precursor ions from a continuous beam of ions. The two or more different precursor ions are transmitted by applying a DC voltage to the barrier electrode lens, creating an electric field potential barrier over which only the resonating ions are transmitted. Precursor ions of product ions from combined product ion spectra produced by multiplexed precursor ion selection are identified by grouping the target precursor ions. 1. A system for multiplexed precursor ion selection and transmission using an electrical field potential barrier , comprising:an ion source that provides a continuous beam of ions;a mass isolator that includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection region and the transmission region and that receives the continuous ion beam from the ion source; anda processor in communication with the ion source and the mass isolator that selects two or more different precursor ions by applying two or more different alternating current (AC) voltage frequencies to the rods of the selection region in order to resonate the two or more different precursor ions from the beam of ions in the selection region andtransmits the two or more different precursor ions from the selection region to the transmission region by applying a direct current (DC) voltage to the barrier electrode lens relative to the rods of the selection region and rods of the transmission region in order to create an electric field potential barrier over which only the resonating two or more different precursor ions ...

Hand and robot

A hand according to an embodiment includes a pair of supporting units, a pair of capturing claws, an opening-and-closing mechanism, and a reciprocating mechanism. The pair of capturing claws are supported on the inner surfaces of the pair of respective supporting units and capture a part. The opening-and-closing mechanism opens and closes the pair of supporting units along a reciprocating axis intersecting with longitudinal directions of the supporting units. The reciprocating mechanism causes the pair of capturing claws to rotate about the reciprocating axis to change the direction of each tip of the capturing claws.

POWER MANAGEMENT SYSTEM AND POWER MANAGEMENT METHOD

A power management system has power supplying means, measuring means that measures power generation environment for the power supplying means, and communication means that transmits information measured by the measuring means. The power management system comprises: a control unit that controls the measuring means and the communication means. The power supplying means is used as a power source for the measuring means and the communication means. The control unit sets a first power threshold to be used for determining whether or not to switch operation states of the measuring means and a second power threshold to be used for determining whether or not to switch operation states of the communication means on the basis of a power supply that is supplied from the power supplying means. 1. A power management system having power supplying means , measuring means that measures power generation environment for the power supplying means , and communication means that transmits information measured by the measuring means , comprising:a control unit that controls the measuring means and the communication means, whereinthe power supplying means is used as a power source for the measuring means and the communication means,the control unit sets a first power threshold to be used for determining whether or not to switch operation states of the measuring means and a second power threshold to be used for determining whether or not to switch operation states of the communication means on the basis of a power supply that is supplied from the power supplying means, andthe control unit switches operation states of the measuring means on the basis of results comparing the power supply with the first power threshold, and switches operation states of the communication means on the basis of results comparing the power supply with the second power threshold.2. The power management system according to claim 1 , wherein a photovoltaic cell is provided as the power supplying means.3. The power ...

Electron Induced Dissociation Devices and Methods

A method and apparatus for conducting reactions between precursor ions and reagent ions, for example, a reaction between a precursor cation and an electron, such as ECD, are disclosed. The apparatus comprises first, second, and third pathways, each of which extends at least partially along a central axis, and wherein the second central axis is orthogonal to the first and third central axes. Charged species can be introduced into the second pathway as the ions are transmitted therethrough, thereby increasing precursor ion and charged species interaction without simultaneous trapping of the species. 1. An ion reaction apparatus , comprising:a first plurality of electrodes arranged to define a first pathway therebetween, the first pathway comprising a first axial end configured to receive ions from an ion source and a second axial end disposed at a distance from the first axial end of the first pathway extending at least partially along a first central axis;a second plurality of electrodes arranged to define a second pathway extending along a second central axis, said second pathway intersecting the first pathway at a first intersection point, the second central axis being substantially orthogonal to the first central axis;a third plurality of electrodes arranged to define a third pathway therebetween, the third pathway comprising a first axial end and a second axial end disposed at a distance from the first axial end of the third pathway to transmit at least one of ions and reaction products of said ions out of the ion reaction apparatus, said third pathway extending at least partially along a third central axis substantially orthogonal to the second central axis and intersecting the second pathway at a second intersection point spaced a distance apart from the first intersection point, wherein the first, second, and third plurality of electrodes are configured to couple to an RF voltage source that provides an RF voltage to each of electrodes of the first, second, ...

PARTICULATE FILTER PROVIDED WITH CATALYST AND METHOD FOR MANUFACTURING SAID FILTER

A catalyst provided for a filter body for combusting PM contains activated aluminas and , active-oxygen-release materials and , catalytic metal , and alkali earth metal . The alkali earth metal is loaded on each of the activated aluminas and , and the active-oxygen-release materials and . A percentage by mass of the alkali earth metal , loaded on the active-oxygen-release materials and , to the active-oxygen-release material is smaller than a percentage by mass of the alkali earth metal , loaded on the activated aluminas and , to the activated alumina. 1. A particulate filter comprising:a filter body configured to collect particulates included in exhaust gas;an exhaust gas pathway wall included in the filter body; anda catalyst provided for the exhaust gas pathway, and configured to combust the particulates, whereinthe catalyst contains activated alumina, an active-oxygen-release material, catalytic metal, and alkali earth metal, the active-oxygen-release material including one, or two or more kinds of oxide taking in oxygen included in the exhaust gas and releasing the oxygen taken in as active oxygen,the alkali earth metal is loaded on each of the activated alumina and the active-oxygen-release material, anda percentage by mass of the alkali earth metal, loaded on the active-oxygen-release material, to the active-oxygen-release material is 1% by mass or smaller, and smaller than a percentage by mass of the alkali earth metal, loaded on the activated alumina, to the activated alumina.2. The particulate filter of claim 1 , whereinthe active-oxygen-release material includes a Ce-containing composite oxide and a Ce-free Zr-based composite oxide,an amount of the alkali earth metal loaded on the activated alumina is greater than a total amount of the alkali earth metal loaded on the Ce-containing composite oxide and the Ce-free Zr-based composite oxide.3. The particulate filter of whereina percentage by mass of the alkali earth metal, loaded on the activated alumina, to ...

Ion Injection Method Into Side-On FT-ICR Mass Spectrometers

Improvements to a side-on Penning trap include methods to stabilize ions in the trap. The ions are stabilized by injecting ions in the focusing region of the non-uniform DC fields produced by the pad electrodes of the trap. Ions are injected along an injection axis shifted from the central axis of a gap between a positively biased electrode pad and negatively biased electrode pad of the trap. Improvements also include methods to compensate for the Lorentz force that is produced when ions are injected into a side-on Penning trap. Electrodes of an ion injection device are DC biased so that the electrodes produce an electric field along the axis of the device that compensates for the Lorentz force. Finally, methods are provided to increase the m/z range of ions injected into a side-on Penning trap by pre-trapping ions just before injection of the ions into the trap. 1. A side-on injection Penning trap that includes a charged particle injection device for injecting charged particles in a focusing region of an electric field , comprising: 'wherein the first set of electrodes includes a central disk electrode and one or more concentric segmented ring electrodes, wherein the central disk electrode and the next adjacent concentric segmented ring electrode are separated by a circular non-conducting path and each concentric segmented ring electrode is separated by the next adjacent concentric segmented ring electrode by a circular non-conducting path, and wherein each of the one or more concentric segmented ring electrodes is segmented by at least two radial non-conducting paths extending from the circular non-conducting path around the central disk electrode to the outer edge of the outermost segmented ring electrode,', 'a first printed circuit board (PCB) on which is printed a first set of electrodes,'} wherein the second PCB is placed in parallel with the first PCB so that the second set of electrodes and the first of electrodes are coaxial and so that each electrode and ...

LIGHT DETECTION DEVICE

A photodetecting device includes a semiconductor substrate including a one-dimensionally distributed plurality of pixels. The photodetecting device includes, for each pixel, a plurality of avalanche photodiodes arranged to operate in Geiger mode, a plurality of quenching resistors electrically connected in series with the respective avalanche photodiodes, and a signal processing unit arranged to process output signals from the plurality of avalanche photodiodes. Light receiving regions of the plurality of avalanche photodiodes are two-dimensionally distributed for each pixel. Each signal processing unit includes a gate grounded circuit and a current mirror circuit electrically connected to the gate grounded circuit. The gate grounded circuit is electrically connected to the plurality of avalanche photodiodes of the corresponding pixel via the plurality of quenching resistors. The current minor circuit is arranged to output a signal corresponding to output signals from the plurality of avalanche photodiodes. 1. A photodetecting device comprising a semiconductor substrate having a first principal surface and a second principal surface opposing each other and including a plurality of pixels one-dimensionally distributed ,wherein, for each of the pixels, the photodetecting device includes:a plurality of avalanche photodiodes including light receiving regions provided in the first principal surface side of the semiconductor substrate, and arranged to operate in Geiger mode;a plurality of quenching resistors provided on the first principal surface side of the semiconductor substrate, and electrically connected in series with the respective avalanche photodiodes; anda signal processing unit arranged to process output signals from the plurality of avalanche photodiodes,wherein the light receiving regions of the plurality of avalanche photodiodes are two-dimensionally distributed for each of the pixels, andeach of the signal processing units includes:a gate grounded circuit ...

EXHAUST GAS PURIFICATION CATALYST AND PRODUCTION METHOD THEREOF

This catalyst includes a lower catalytic layer having catalytic ability to oxidize HC and CO and an upper catalytic layer having catalytic ability to reduce NO. The lower catalytic layer contains Pt and Pd acting as catalytic metals, zeolite, a Ce-containing oxide, and activated alumina, and the upper catalytic layer contains activated alumina loading an Rh-doped Ce-containing oxide and an NOstorage material. 1. An exhaust gas purification catalyst comprising:a lower catalytic layer having catalytic ability to oxidize HC and CO on a substrate; and{'sub': 'x', 'an upper catalytic layer having catalytic ability to reduce NOon top of, or above, the lower catalytic layer, wherein'}the lower catalytic layer contains Pt and Pd acting as catalytic metals, zeolite, Ce-containing oxide, and activated alumina, and{'sub': 'x', 'the upper catalytic layer contains activated alumina loading an Rh-doped Ce-containing oxide and an NOstorage material.'}2. The exhaust gas purification catalyst of claim 1 , whereinthe lower catalytic layer includes a first oxidation catalyst layer containing activated alumina loading Pt and Pd and a Ce-containing oxide loading Pt and Pd, and a second oxidation catalyst layer containing zeolite loading Pt and Pd, andthe second oxidation catalyst layer is disposed on the first oxidation catalyst layer.3. The exhaust gas purification catalyst of claim 1 , wherein{'sub': 'x', 'an intermediate catalytic layer is provided between the lower and upper catalytic layers, the intermediate catalytic layer containing Pt and Rh acting as catalytic metals, activated alumina, a Ce-containing oxide and an NOstorage material, and containing no Pd.'}4. The exhaust gas purification catalyst of claim 2 , wherein{'sub': 'x', 'an intermediate catalytic layer is provided between the lower and upper catalytic layers, the intermediate catalytic layer containing Pt and Rh acting as catalytic metals, activated alumina, a Ce-containing oxide and an NOstorage material, and ...

SEMICONDUCTOR DEVICE

In a plane including the center line of a vertical through hole, it is assumed that a segment that connects a first point corresponding to the edge of an opening of an insulating layer and a second point corresponding to the edge of a second opening is a first segment, a segment that connects the second point and a third point corresponding to an intersection point between the second opening and a surface of the insulating layer is a second segment, and a segment that connects the third point and the first point is a third segment. In the insulating layer, the first area located on one side with respect to the first segment is larger than the sum of the second area surrounded by the first, the second and the third segments and the third area located on the other side with respect to the third segment. 1. A semiconductor device comprising:a semiconductor substrate that has a first surface and a second surface opposite to each other and in which a through hole to extend from the first surface to the second surface is formed;a first wiring that is provided on the first surface and has a portion located above a first opening of the through hole on the first surface side;an insulating layer that is provided on an inner surface of the through hole and the second surface and is continuous through a second opening of the through hole on the second surface side; anda second wiring that is provided on a surface of the insulating layer and is electrically connected to the first wiring in an opening of the insulating layer on the first surface side,wherein the through hole is a vertical hole, andin a case in which attention is paid to regions on both sides of a center line of the through hole in a plane including the center line of the through hole, when a segment that connects a first point corresponding to an edge of the opening of the insulating layer and a second point corresponding to an edge of the second opening is a first segment, a segment that connects the second ...

Acquisition Strategy for Top-Down Analysis with Reduced Background and Peak Overlapping

Intensity measurements made by electron multiplier and image-charge detectors are proportional to charge state. These intensities are used to separate detected ions into different data sets and create mass spectra from the different data sets. Ion measurements are separated by charge state using (i) a single electron multiplier detector, (ii) a single image-charge detector, or (iii) multiple electron multiplier ADC detectors. Using (i), the intensity of a peak calculated from each measured pulse is compared to predetermined intensity ranges and each peak is stored in a corresponding data set. Using (ii), each measured transient time-domain signal is converted to frequency-domain peaks, the intensity of each frequency-domain peak is compared to predetermined intensity ranges, and each peak is stored in a corresponding data set. Using (iii), each detector is adapted to measure a predetermined intensity range and store calculated peaks from the measured pulses in corresponding data sets. 1. A system for separating ions measured by a mass analyzer into two or more mass spectra based on charge state using a single electron multiplier analog-to-digital conversion (ADC) detector , comprising:a mass spectrometer that includes a mass analyzer, wherein the mass analyzer includes an electron multiplier ADC detector that produces detection pulses for detected ions with intensities that are proportional to ion charge state; and{'claim-text': ['instructs the mass analyzer to detect a pulse for each ion impacting the ADC detector from a plurality of ions that are transmitted to the mass analyzer by the mass spectrometer,', 'calculates a peak for each pulse detected using peak finding,', 'calculates an intensity for each peak,', 'compares the intensity of each peak to two or more different predetermined intensity ranges corresponding to two or more different charge state ranges and stores each peak in one of two or more data sets corresponding to the two or more predetermined ...

TOF Mass Calibration

A calibration apparatus for a mass analyzer includes an ion source device and a dual-purpose electron beam generating unit. The ion source device ionizes an analyte of a sample, producing analyte ions. The dual-purpose electron beam generating unit is positioned between the ion source device and the mass analyzer. In a first mode, the dual-purpose electron beam generating unit is used to create fragments of analyte ions of unknown mass-to-charge ratio. In a second mode, the dual-purpose electron beam generating unit is used to create ions of calibration compounds of known mass-to-charge ratio. All ions are subsequently transferred to the mass analyzer. 1. A mass calibration apparatus for a mass analyzer , comprising:an ion source device of a mass spectrometer for ionizing an analyte of a sample, producing analyte ions; and in a first mode, when the mass spectrometer is in mass spectrometry (MS) mode, transmits the analyte ions to the mass analyzer directly or through one or more other units of the mass spectrometer for mass analysis or, when the mass spectrometer is in mass spectrometry/mass spectrometry (MS/MS) mode, fragments the analyte ions into product ions and transmits the product ions to the mass analyzer directly or through the one or more other units for mass analysis or transmits the analyte ions to a collision cell of the mass spectrometer for fragmentation that, in turn, transmits resulting product ions to the mass analyzer for mass analysis, and,', 'in a second mode, creates ions of calibration compounds and transmits the calibration ions to the mass analyzer directly or through the one or more other units for mass analysis., 'a dual-purpose electron beam generating unit of the mass spectrometer located between the ion source device and a mass analyzer of the mass spectrometer that,'}2. The apparatus of claim 1 , wherein the dual-purpose electron beam generating unit is an electron-based dissociation (ExD) cell claim 1 , wherein claim 1 , in the first ...

Top Down Analysis of Antibodies in Mass Spectrometry

A separation device separates an unknown intact mAb or reduced mAb subunits of a known mAb class from a sample. M An ion source device ionizes the mAb. A mass spectrometer fragments the ionized mAb using an ECD device and mass analyzes resulting product ions using a mass analyzer, producing one or more product ion spectra. Theoretical product ion peaks are calculated for one or more constant portions of the mAb class. The theoretical product ion peaks are removed from the one or more product ion spectra, producing one or more difference product ion spectra. De novo sequencing is applied to the one or more difference product ion spectra, producing one or more candidate sequences for one or more variable portions of the mAb. A genome database is searched for matches to the one or more candidate sequences, producing one or more matched sequences for the one or more variable portions. 1. A system for sequencing one or more variable portions of an unknown monoclonal antibody (mAb) , comprising:a genome database for homology search;a separation device,a ion source device;a mass spectrometer that includes a dissociation device and a mass analyzer; and instructs the separation device to separate an unknown intact mAb or reduced mAb subunits of a known mAb class from a sample,', 'instructs the ion source device to ionize the unknown intact mAb or reduced mAb subunits,', 'instructs the mass spectrometer to fragment the ionized unknown intact mAb or reduced mAb subunits using the dissociation device and mass analyze resulting product ions using the mass analyzer, producing one or more product ion spectra,', 'calculates theoretical product ion peaks for one or more constant portions of the known mAb class,', 'removes the calculated theoretical product ion peaks from the one or more product ion spectra, producing one or more difference product ion spectra,', 'applies de novo sequencing to the one or more difference product ion spectra, producing one or more candidate sequences ...

Top Down Protein Identification Method

Systems and methods described herein can provide for “top down” mass spectrometric analysis of proteins or peptides in a sample using ExD, in some aspects via direct infusion of the sample to the ion source without on-line LC separation, while deconvoluting the ambiguity in the ExD spectra generated by impure samples. For example, methods and systems in accordance with various aspects of the present teachings can utilize patterns in charge-reduced species following ExD to correlate the ExD fragments with their precursor ions in order to more confidently identify the precursor ion from which the detected product ions originated. 1. A method of processing a sample , comprising:utilizing an ion source to generate a plurality of precursor peptide or protein ions from a sample solution containing at least one peptide or protein;scanning a mass range of the precursor ions using a plurality of m/z isolation windows;subjecting the precursor ions within each of the m/z isolation windows to an ExD reaction;detecting product ions resulting from each of the ExD reactions so as to generate a plurality of ExD spectra corresponding to each of the m/z isolation windows, wherein at least a first ExD spectra corresponding to a first m/z isolation window exhibits one or more ExD fragment ions and one or more charge reduced species of the precursor ions within the first m/z isolation window; anddetermining a precursor charge state and a molecular weight for one or more species of the precursor ions within the first m/z isolation window at least partially based on a m/z of the said one or more species of precursor ions within the first m/z isolation window and a m/z of the one or more charge reduced species of the precursor ions.2. The method of claim 1 , further comprising introducing the sample solution to the ion source via direct infusion.3. The method of claim 1 , wherein each of the m/z isolation windows has a range of about 1 Da.4. The method of claim 1 , wherein the first ExD ...

Analysis Method for Glycoproteins

A mass isolation device selects a precursor ion of a sample that has been digested using a protease. A first fragmentation device fragments the precursor ion using collision-induced dissociation (CID), and the resulting product ions are analyzed using a mass analyzer producing a CID spectrum. A list of theoretical candidate glycopeptide sequences is determined from CID spectrum. The mass isolation device again selects the precursor ion of the sample. A second fragmentation device fragments the precursor ion using electron-based dissociation (ExD), and the resulting product ions are analyzed using the mass analyzer producing a CID spectrum. For each sequence of the list, the sequence is computationally fragmented, producing theoretical fragments, mass-to-charge ratio (m/z) values are calculated for the theoretical fragments, and the sequence is scored using c and z fragment matching rules. The highest scoring sequence is identified as a peptide sequence of a glycopeptide of the sample. 1. A system for operating tandem mass spectrometer to identify a peptide sequence of a glycopeptide of a sample , comprising:an ion source device adapted to receive and ionize a sample that has been digested using a protease, producing an ion beam;a mass isolation device of a tandem mass spectrometer (MS/MS) adapted to select precursor ions from the ion beam of the ion source device;a first fragmentation device of the MS/MS adapted to fragment selected precursor ions using collision-induced dissociation (CID) and to produce product ions;a second fragmentation device of the MS/MS adapted to fragment selected precursor ions using electron-based dissociation (ExD) and to produce product ions;a mass analyzer of the MS/MS adapted to mass analyze product ions from the first or second fragmentation device and produce a product ion spectrum; anda processor in communication with that tandem mass spectrometer that(i) instructs the mass isolation device to select at least one precursor ion from a ...

Inline Ion Reaction Device Cell and Method of Operation

A method and apparatus for conducting ion to charged species reactions, more particularly reactions wherein the charged species is an electron, such as ECD. The apparatus comprises first and second pathways which are orthogonal to one another. The first pathway through which ions are introduced comprises multiple multipoles with a gap situated there between. The second pathway introduces the charged species through the gap orthogonally to the first pathway. In this way, a cross-type reaction device allows ion-charged species interactions to occur. 1. A reaction apparatus for ions comprising:a first pathway comprising a first axial end and a second axial end disposed at a distance from the first pathway axial end along a first central axis;a second pathway comprising a first axial end and a second axial end disposed at a distance from the first axial end of the second pathway along a second central axis;said first and second central axis being substantially orthogonal to one another and having an intersection point;a first set of quadrupole electrodes arranged in a quadrupole orientation around said first central axis and disposed between said first axial end of said first pathway and said intersection point, said first set of electrodes for guiding ions along a first portion of said first central axis;a second set of quadrupole electrodes arranged in a quadrupole orientation around said first central axis and disposed between said second axial end of said first pathway and said intersection point, said second set of electrodes for guiding ions along a second portion of said first central axis;the first set of electrodes being separated from the second set of electrodes so as to form a gap transverse to said first central axis;a voltage source for providing an RF voltage to said first and second sets of electrodes to generate an RF field;a controller for controlling said RF voltages;an ion source disposed at or proximate either the first or second axial end of said ...

CATALYZED PARTICULATE FILTER

A filter is configured for efficient combustion of particulates accumulated on a catalyst layer in both a rapid combustion range and a slow combustion range. The catalyst layer on an exhaust gas passage wall of a filter includes a mixture of a Rh-doped Ce-containing composite oxide particle material loaded with Pt and a composite particle material loaded with Pt. In mixed particles of this mixture, Zr-containing composite oxide particles containing no Ce and activated alumina particles are mixed together and agglomerated. 1. A catalyzed particulate filter comprising:an exhaust gas passage wall on which particulates in exhaust gas are to be collected; anda catalyst layer located on the exhaust gas passage wall and including Ce-containing composite oxide, Zr-containing composite oxide containing no Ce, activated alumina, and catalytic metals, whereinthe catalytic metals include Rh and Pt,the Ce-containing composite oxide included in the catalyst layer is in a state of Rh-doped Ce-containing composite oxide particles containing Zr and Nd, doped with Rh as one of the catalytic metals, and having an oxygen storage/release capacity,the Rh-doped Ce-containing composite oxide particles are loaded with Pt as one of the catalytic metals,the Zr-containing composite oxide is Zr-containing composite oxide containing Nd and Pr and having an oxygen ion conduction,the Zr-containing composite oxide and the activated alumina included in the catalyst layer are in a state of mixed particles in which Zr-containing composite oxide particles and activated alumina particles are mixed together and agglomerated,the mixed particles are loaded with Pt as one of the catalytic metals, andthe Rh-doped Ce-containing composite oxide particles and the mixed particles are mixed such that a mass ratio among the Zr-containing composite oxide, the activated alumina, and the Rh-doped Ce-containing composite oxide is within a range enclosed by point A (18+3/4, 6+1/4, 75), point B (6+1/4, 18+3/4, 75), ...

Apparatus and Method for Glycopeptide Analysis

A system and method is described for characterizing glycopeptides which includes a first quadrupole mass filter, a multipole rod set of an ion guide, a lens electrode, an ExD device and a mass analyzer. The multipole rod set is adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage The lens electrode is adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage. The ExD device performs electron capture dissociation or electron transfer dissociation, the ExD device being positioned so that an entrance of the ExD device is disposed on the other side of the lens electrode opposite the multipole rod set. The mass analyzer is positioned at an exit of the ExD device for receiving ions from the ExD device. 1. A system for mass spectrometer analysis comprising:a first quadrupole mass filter;a multipole rod set of an ion guide to receive ions from the first quadrupole mass filter, the multipole rod set adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage,a lens electrode of the ion guide positioned at one end of the multipole rod set to extract ions trapped by the multipole rod set and adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage,an ExD device adapted to perform electron capture dissociation or electron transfer dissociation, the ExD device being positioned so that an entrance of the ExD device is disposed on the other side of the lens electrode opposite the multipole rod set,a mass analyzer positioned at an exit of the ExD device for receiving ions from the ExD device,a processor in communication with the multipole rods set and the lens electrode that simultaneously applies a radial dipole DC voltage to the multipole rod set and an axial trapping AC voltage to the lens electrode or simultaneously applies a radial RF trapping voltage amplitude to the multipole rode set and an axial ...

LIGHT DETECTION DEVICE

A semiconductor light detection element has a plurality of channels, each of which consists of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode, quenching resistors connected in series to the respective avalanche photodiodes, and signal lines to which the quenching resistors are connected in parallel. A mounting substrate is configured so that a plurality of electrodes corresponding to the respective channels are arranged on a third principal surface side and so that a signal processing unit for processing output signals from the respective channels is arranged on a fourth principal surface side. In a semiconductor substrate, through-hole electrodes electrically connected to the signal lines are formed for the respective channels. The through-hole electrodes and the electrodes are electrically connected through bump electrodes. 16-. (canceled)7. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other; anda mounting substrate disposed as opposed to the semiconductor light detection element and having a third principal surface opposed to the second principal surface of the semiconductor substrate and a fourth principal surface opposed to the third principal surface,wherein the semiconductor light detection element has a photodiode array, the photodiode array including a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and disposed on the first principal surface side of the semiconductor substrate, and signal lines to which the quenching resistors are connected in parallel and which are disposed on the first principal surface side of the semiconductor substrate,wherein the mounting substrate is provided with a first electrode disposed on the third principal surface side,wherein ...

LIGHT DETECTION DEVICE

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through bump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other. 17-. (canceled)8. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other, a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate,', 'quenching resistors connected in series to the respective avalanche photodiodes and arranged on the first principal surface side of the semiconductor substrate,', 'a through-hole electrode electrically connected to the quenching resistors and formed to penetrate the semiconductor substrate from the first principal surface side to the second principal surface side, and', 'a bump electrode electrically connected to the through-hole electrode and arranged on the second principal surface side of the semiconductor substrate, and, 'wherein the semiconductor light detection element includes'}wherein interconnection distances from the respective avalanche photodiodes to the bump electrode through the corresponding quenching resistor and the through-hole electrode are approximately ...

LIGHTING CONTROL APPARATUS, LIGHTING CONTROL SYSTEM AND LIGHTING CONTROL METHOD

The lighting control apparatus has a memory unit, an operation input unit and a control unit. The memory unit stores an outer frame and addresses of luminaires and operating devices. The operation input unit inputs to designate a position where a small area is provided in a predetermined area on a layout drawing. The control unit provides, based on the outer frame and the addresses, a layout drawing that illustrates positions where luminaires and operating devices are arranged in the predetermined range within the outer frame. The control unit determines the luminaire and the operating device arranged in the small area. The control unit gives an operation right of the luminaire arranged in the small area to the operating device arranged in the same small area. 1. A lighting control apparatus comprising:a memory unit configured to store a layout drawing illustrating an arrangement of a plurality of luminaires and a plurality of operating devices in a predetermined area and addresses corresponding to respective positions where the luminaires and the operating devices are arranged;an input unit configured to input to designate a position where a small area is provided in the predetermined area on the layout drawing; anda control unit configured to determine, based on the addresses stored in the memory unit, the luminaires and the operating devices arranged in the small area designated by an input on the layout drawing, and to give an operation right of the determined luminaires to the operating devices arranged in the small area.2. The lighting control apparatus according to claim 1 , wherein the control unit gives a warning when at least one of the luminaire and the operating device is not arranged in the small area.3. The lighting control apparatus according to claim 2 , wherein claim 2 , even if the luminaire is arranged and the operating device is not arranged in the small area claim 2 , the control unit does not give a warning when a receiver corresponding to a ...

BACK-ILLUMINATED SEMICONDUCTOR LIGHT DETECTING DEVICE

A back-illuminated semiconductor light detecting device includes a light detecting substrate having pixels, and a circuit substrate having signal processing units. For each of the pixels, the light detecting substrate includes avalanche photodiodes respectively having light receiving regions provided in a first main surface side of the semiconductor substrate. In the semiconductor substrate, for each pixel, a trench surrounds at least one region including the light receiving region when viewed from a direction perpendicular to the first main surface. The number of signal processing units is larger than the number of light receiving regions in each pixel, and the number of regions surrounded by the trench in each pixel is equal to or less than the number of light receiving regions in the pixel. 1. A back-illuminated semiconductor light detecting device comprising:a light detecting substrate including a semiconductor substrate having a first main surface and a second main surface facing each other and including a plurality of pixels which are two-dimensionally disposed on the semiconductor substrate; anda circuit substrate connected to the light detecting substrate and including a plurality of signal processing units, each of the signal processing units configured to process an output signal from a corresponding pixel of the pixels, whereinthe light detecting substrate includes, for each of the pixels:a plurality of avalanche photodiodes respectively having light receiving regions provided in the first main surface side of the semiconductor substrate and configured to operate in Geiger mode;a plurality of quenching resistors disposed on the first main surface side of the semiconductor substrate, each of the quenching resistors electrically connected in series to a corresponding avalanche photodiode of the avalanche photodiodes; andpad electrodes disposed on the first main surface side of the semiconductor substrate and electrically connected to the plurality of ...

LIGHT DETECTION DEVICE

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through bump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other. 1. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other;a mounting substrate arranged as opposed to the semiconductor light detection element and having a third principal surface opposed to the second principal surface of the semiconductor substrate; anda glass substrate arranged as opposed to the semiconductor light detection element and having a fourth principal surface opposed to the first principal surface of the semiconductor substrate,wherein the semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on the first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to the ...

OPTICAL SENSOR

A photodetecting device includes a semiconductor substrate including a first principal surface and a second principal surface that oppose each other and a plurality of through-electrodes penetrating through the semiconductor substrate in a thickness direction. The semiconductor substrate includes a plurality of avalanche photodiodes arranged to operate in Geiger mode. The plurality of through-electrodes are electrically connected to the corresponding avalanche photodiodes. The semiconductor substrate includes a first area in which the plurality of avalanche photodiodes are distributed in at least a first direction and a second area in which the plurality of through-electrodes are distributed two-dimensionally. The first area and the second area are distributed in a second direction orthogonal to a first direction when viewed from a direction orthogonal to the first principal surface. 1. A photodetecting device comprising:a semiconductor substrate including a first principal surface and a second principal surface that oppose each other, and including a plurality of avalanche photodiodes arranged to operate in Geiger mode; anda plurality of through-electrodes electrically connected to corresponding avalanche photodiodes of the plurality of avalanche photodiodes and penetrating through the semiconductor substrate in a thickness direction,wherein the semiconductor substrate includes:a first area in which the plurality of avalanche photodiodes are distributed in at least a first direction; anda second area in which the plurality of through-electrodes are distributed two-dimensionally, andwherein the first area and the second area are distributed in a second direction orthogonal to the first direction when viewed from a direction orthogonal to the first principal surface.2. The photodetecting device according to claim 1 , wherein avalanche photodiodes of the plurality of avalanche photodiodes whose positions in the first direction are different from each other are ...

Exhaust gas purification catalyst and method for manufacturing same

An exhaust gas purification catalyst is disposed in an exhaust gas channel of an engine and includes a catalytic layer 22 provided on a substrate 21 . The catalytic layer 22 contains multiple types of γ-aluminas 23 and 24 which are different in composition and Pt 25 loaded on the multiple types of γ-aluminas 23 and 24.

LIGHT DETECTION DEVICE

A light detection device has a semiconductor light detection element having a semiconductor substrate, and a mounting substrate arranged as opposed to the semiconductor light detection element. The semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and electrodes electrically connected to the respective avalanche photodiodes and arranged on a second principal surface side of the semiconductor substrate. The mounting substrate includes a plurality of electrodes arranged corresponding to the respective electrodes on a third principal surface side, and quenching resistors electrically connected to the respective electrodes and arranged on the third principal surface side. The electrodes and the electrodes are connected through bump electrodes. 1. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other; anda mounting substrate arranged as opposed to the semiconductor light detection element and having a third principal surface opposed to the second principal surface of the semiconductor substrate,wherein the semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and first electrodes electrically connected to the respective avalanche photodiodes and arranged on the second principal surface side of the semiconductor substrate,wherein the mounting substrate includes a plurality of second electrodes arranged corresponding to the respective first electrodes on the third principal surface side, and quenching circuits electrically connected to the respective second electrodes and arranged on the third principal surface side, andwherein the first electrodes and the second electrodes corresponding to the first electrodes are connected through bump electrodes.2. The ...

Method for Top Down Proteomics Using ExD and PTR

A dissociation device fragments a precursor ion, producing at least two different product ions with overlapping m/z values in the dissociation device. The dissociation device applies an AC voltage and a DC voltage creating a pseudopotential that traps ions below a threshold m/z including the at least two product ions. The dissociation device receives a charge reducing reagent that causes the trapped at least two product ions to be charge reduced until their m/z values increase above the threshold m/z set by the AC voltage. The increase in the m/z values of the at least two product ions decreases their overlap. The at least two product ions with increased m/z values are transmitted to another device for subsequent mass analysis by applying the DC voltage to the dissociation device relative to a DC voltage applied to the other device. 1. Apparatus for reducing the charge of at least two product ions in order to move the mass-to-charge ratio (m/z) values of the at least two product ions above a threshold m/z value and decrease overlap among the m/z values of the at least two product ions before mass analysis , comprising:a reagent source device that supplies charge reducing reagent; anda dissociation device that receives a precursor ion, dissociates the precursor ion, producing a plurality of product ions in the dissociation device, receives the charge reducing reagent from the reagent source device, applies an alternating current (AC) voltage and a direct current (DC) voltage to one or more electrodes of the dissociation device that creates a pseudopotential in an axial direction to trap product ions of the plurality of product ions with m/z values below a threshold m/z in the dissociation device and to, in turn, cause the trapped product ions to be charge reduced by the received charge reducing reagent so that m/z values of at least two product ions of the trapped product ions increase to m/z values above the threshold m/z, and applies the DC voltage to the one or ...

LIGHT DETECTION DEVICE

A semiconductor light detection element has a plurality of channels, each of which consists of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode, quenching resistors connected in series to the respective avalanche photodiodes, and signal lines to which the quenching resistors are connected in parallel. A mounting substrate is configured so that a plurality of electrodes corresponding to the respective channels are arranged on a third principal surface side and so that a signal processing unit for processing output signals from the respective channels is arranged on a fourth principal surface side. In a semiconductor substrate, through-hole electrodes electrically connected to the signal lines are formed for the respective channels. The through-hole electrodes and the electrodes are electrically connected through bump electrodes. 1. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other; anda mounting substrate arranged as opposed to the semiconductor light detection element and having a third principal surface opposed to the second principal surface of the semiconductor substrate and a fourth principal surface opposed to the third principal surface,wherein the semiconductor light detection element has a plurality of channels, each channel consisting of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on the first principal surface side of the semiconductor substrate, and signal lines to which the quenching resistors are connected in parallel and which are arranged on the first principal surface side of the semiconductor substrate,wherein the mounting substrate is configured so that a plurality of first electrodes corresponding to ...

EXHAUST GAS PURIFYING CATALYST, METHOD FOR PRODUCING SAME, AND EXHAUST GAS PURIFICATION METHOD USING SAME

An exhaust gas purify catalyst includes a substrate (), an oxidation catalyst layer () formed on the substrate () and containing zeolite and at least one catalytic metal, an LNT layer () formed on the oxidation catalyst layer () and containing an NOstorage material and at least one catalytic metal, and an NOreduction layer () formed on the LNT layer () and containing Rh acting as a catalytic metal and at least one of alumina or zirconia, wherein the NOreduction layer () has a larger content of Rh than that in each of the oxidation catalyst layer () and the LNT layer (). 1. An exhaust gas purifying catalyst comprising:a substrate;an oxidation catalyst layer formed on the substrate, and containing zeolite and at least one catalytic metal;{'sub': x', 'x, 'a lean NOtrap (LNT) layer formed on the oxidation catalyst layer, and containing an NOstorage material and at least one catalytic metal;'}{'sub': 'x', 'an NOreduction layer formed on the LNT layer, and containing Rh acting as a catalytic metal and at least one of alumina or zirconia, wherein'}{'sub': 'x', 'the NOreduction layer has a larger content of Rh than in each of the oxidation catalyst layer and the LNT layer.'}2. The exhaust gas purifying catalyst of claim 1 , whereinthe oxidation catalyst layer includes a first oxidation catalyst layer containing alumina and ceria, and a second oxidation catalyst layer formed on the first oxidation catalyst layer and containing zeolite.3. The exhaust gas purifying catalyst of claim 1 , whereinthe LNT layer further contains alumina and ceria.4. The exhaust gas purifying catalyst of claim 2 , whereinthe LNT layer further contains alumina and ceria.5. The exhaust gas purifying catalyst of claim 1 , whereinzeolite in the oxidation catalyst layer has an average particle size of 0.5 μm or more and 4.8 μm or less.6. The exhaust gas purifying catalyst of claim 2 , whereinzeolite in the oxidation catalyst layer has an average particle size of 0.5 μm or more and 4.8 μm or less.7. The ...

Method of extracting ions with a low m/z ratio from an ion trap

In a mass spectrometer, a method for trapping ions includes providing at least first and second multipole rod sets positioned in tandem, introducing a plurality of ions into the first rod set, applying an RF potential to at least one of said rod sets to generate a radial trapping potential within said rod sets, applying a radial DC potential to said first rod set so as to modulate said radial trapping potential set as a function of m/z of said ions, and applying a DC potential between said two rod sets to provide an axial bias potential between said two rod sets. The method can further comprise selecting an axial barrier potential to selectively extract ions having an m/z ratio less than a threshold from said first rod set into said second rod set.

LIGHT DETECTION DEVICE

A light detection device has a semiconductor light detection element having a semiconductor substrate, and a mounting substrate arranged as opposed to the semiconductor light detection element. The semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and electrodes electrically connected to the respective avalanche photodiodes and arranged on a second principal surface side of the semiconductor substrate. The mounting substrate includes a plurality of electrodes arranged corresponding to the respective electrodes on a third principal surface side, and quenching resistors electrically connected to the respective electrodes and arranged on the third principal surface side. The electrodes and the electrodes are connected through bump electrodes. 15-. (canceled)6. A light detection device comprising:a semiconductor light detection element including a semiconductor substrate including first and second principal surfaces opposed to each other, a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and first electrodes electrically connected to the respective avalanche photodiodes and arranged on the second principal surface side of the semiconductor substrate:a mounting substrate including a third principal surface opposed to the second principal surface of the semiconductor substrate, and a plurality of second electrodes arranged corresponding to the respective first electrodes on the third principal surface side, the mounting substrate being, arranged as opposed to the semiconductor light detection element; andquenching circuits electrically connected to the respective second electrodes,wherein the first electrodes and the second electrodes corresponding to the first electrodes are electrically connected through bump electrodes, andwherein the quenching circuits are not arranged on the semiconductor substrate of the ...

SEMICONDUCTOR PHOTODETECTION DEVICE

A semiconductor substrate has a first main surface and a second main surface that oppose each other and a plurality of cells that are arrayed two-dimensionally in a matrix. Each cell includes at least one avalanche photodiode arranged to operate in a Geiger mode. A trench penetrating through the semiconductor substrate is formed in the semiconductor substrate to surround each cell when viewed in a direction orthogonal to the first main surface. A light-shielding member optically separates mutually adjacent cells of the plurality of cells. The light-shielding member includes a first portion extending in a thickness direction of the semiconductor substrate between an opening end of the trench at the first main surface and an opening end of the trench at the second main surface and a second portion projecting out from the second main surface. The insulating film includes a portion that covers the second portion. 1. A semiconductor photodetection device comprising:a semiconductor substrate having a first main surface and a second main surface that oppose each other and a plurality of cells that are arrayed two-dimensionally in a matrix;a first wire that is disposed on the first main surface of the semiconductor substrate and is electrically connected to each of the plurality of cells;a second wire that is disposed on the first main surface of the semiconductor substrate and is electrically connected to each of the plurality of cells;a light-shielding member that optically separates mutually adjacent cells of the plurality of cells; andan insulating film that covers the light-shielding member; andwherein each of the plurality of cells includes at least one avalanche photodiode arranged to operate in a Geiger mode,the avalanche photodiode includes a first semiconductor region and a second semiconductor region of a conductivity type differing from the first semiconductor region,the first semiconductor region and the second semiconductor region form a portion of the first ...

Ion guide for mass spectrometry

An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice. A deflection plate is disposed within the enclosure between the proximal and distal ends and deflects at least a portion of the gas flow away from a central direction of the gas flow. A plurality of electrically conductive, elongate elements extend from the proximal end to the distal end within the enclosure and generate an electric field via a combination of RF and DC electric potentials. The electric field deflects the entrained ions away from the central direction of the gas flow proximal to the deflection plate and confines the deflected ions in proximity of the elongated elements as the ions travel downstream.

EXHAUST GAS COMPONENT PURIFICATION CATALYTIC MATERIAL AND CATALYZED PARTICULATE FILTER WITH THE CATALYTIC MATERIAL

An exhaust gas component purification catalytic material for use in removal of particulates in an exhaust gas through combustion includes: composite oxide particles containing zirconium and neodymium and not containing cerium; and praseodymium oxide particles in contact with the composite oxide particles 1. An exhaust gas component purification catalytic material for use in removal of particulates in an exhaust gas through combustion , the exhaust gas component purification catalytic material comprising:composite oxide particles containing zirconium and neodymium and not containing cerium; andpraseodymium oxide particles in contact with the composite oxide particles.2. The exhaust gas component purification catalytic material of claim 1 , whereinthe composite oxide particles and the praseodymium oxide particles are mixed together and in contact with one another.3. The exhaust gas component purification catalytic material of claim 1 , whereinone of the composite oxide particles or the praseodymium oxide particles form cores, and the other are loaded on surfaces of the cores.4. The exhaust gas component purification catalytic material of claim 1 , whereinthe composite oxide particles are at least one type of composite oxide particles selected from the group consisting of: ZrNd composite oxide particles containing zirconium, neodymium, and oxygen; ZrNdPr composite oxide particles containing zirconium, neodymium, praseodymium, and oxygen; ZrNdLa composite oxide particles containing zirconium, neodymium, lanthanum, and oxygen; and ZrNdY composite oxide particles containing zirconium, neodymiumm, yttrium, and oxygen.5. The exhaust gas component purification catalytic material of claim 2 , whereinthe composite oxide particles are at least one type of composite oxide particles selected from the group consisting of: ZrNd composite oxide particles containing zirconium, neodymium, and oxygen; ZrNdPr composite oxide particles containing zirconium, neodymium, praseodymium, and ...

ELECTRON BEAM THROTTLING FOR ELECTRON CAPTURE DISSOCIATION

In one aspect, an electron-ion reaction module, e.g., an electron capture dissociation module, for use in a mass spectrometer is disclosed, which comprises a chamber, an electron source for generating electrons and introducing the electrons into the chamber, a gate electrode positioned relative to the electron source and the chamber, and a DC voltage source operatively coupled to the gate electrode for applying control voltages to the gate electrode. The electron-ion interaction module can further include a controller operably coupled to the DC voltage source and configured for adjusting the DC voltage applied to the gate electrode to adjust flow of electrons into the chamber. 1. An electron-ion reaction module for use in a mass spectrometer , comprising:a chamber,an electron source for generating electrons and introducing said electrons into the chamber,a gate electrode positioned relative to the electron source and the chamber,a DC voltage source operatively coupled to said gate electrode for applying control voltages to said gate electrode, anda controller operably coupled to said DC voltage source and configured for adjusting the DC voltage applied to the gate electrode to adjust flow of electrons into the chamber.2. The electron-ion reaction module of claim 1 , wherein said controller adjusts the DC voltage applied to the gate electrode by switching the DC voltage between a plurality of discrete voltage levels.3. The electron-ion reaction module of claim 2 , wherein one of said discrete voltage levels corresponds to a state of the gate (herein “on-state”) during which the gate allows introduction of the electrons into said chamber and another one of said discrete voltage levels corresponds to another state of said gate (herein “off-state”) during which the gate inhibits introduction of the electrons into said chamber.4. The electron-ion reaction module of claim 3 , wherein said controller adjusts periodicity of said “on” and “off” voltages so as to adjust ...

Spatial, Mass and Energy Focused Ion Injection Method and Device

In one aspect, an ion trap is disclosed, which includes a curved linear ion trap having a plurality of electrodes arranged around a central curved axis so as to provide a volume for trapping ions, said plurality of electrodes comprising at least one inner electrode and at least one outer electrode radially separated from said inner electrode. The ion trap further includes a pair of inner and outer ion guide electrodes providing a volume therebetween for receiving ions ejected from said curved ion trap and guiding the ejected ions to one or more spatial locations along a focal line, said inner and outer ion guide electrodes being positioned external to said ion trapping volume and in proximity of said at least inner and outer electrodes of the curved ion trap, respectively, wherein a DC voltage is applied between said ion guide electrodes to provide an electric filed therebetween for guiding the ejected ions to said spatial locations. 1. An ion trap , comprising:a curved linear ion trap having a plurality of electrodes arranged around a central curved axis to provide a volume for trapping ions, said plurality of electrodes comprising at least one inner electrode and at least one outer electrode radially separated from said inner electrode,a pair of inner and outer ion guide electrodes providing a volume therebetween for receiving ions ejected from said curved ion trap and guiding the ejected ions to one or more spatial locations along a focal line, said inner and outer ion guide electrodes being positioned external to said ion trapping volume and in proximity of said at least inner and outer electrodes of the curved ion trap, respectively,wherein a DC voltage is applied between said ion guide electrodes to provide an electric field therebetween for guiding the ejected ions to said focal line.2. The ion trap of claim 1 , wherein said ion guide electrodes are configured to receive the ejected ions along directions substantially orthogonal to said central axis.3. The ...

METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER

A method and apparatus is provided including an ion source for generating ions, a vacuum chamber having an inlet aperture for receiving ions and an exit aperture for passing ions from the vacuum chamber. At least one ion guide is provided between the inlet and exit apertures, the at least one ion guide having an entrance end and an exit end. The at least one ion guide having an inner cylinder and an outer cylinder. The inner cylinder having a plurality of sections, each section having a different number of slots and the inner cylinder coaxially disposed within the outer cylinder wherein the inner cylinder is configured to generate more than one multipole field. A power supply is provided for providing an RF voltage between the outer and inner cylinders. 1. A mass spectrometer system , comprising:an ion source for generating ions from a sample;a vacuum chamber comprising an inlet aperture for receiving the ions, and an exit aperture for passing ions from the vacuum chamber;at least one ion guide between the inlet and exit apertures, the at least one ion guide having an entrance end and an exit end;the at least one ion guide comprising an inner cylinder and an outer cylinder, the inner cylinder having a plurality of sections, each section comprising a plurality of slots in the inner cylinder and each of the plurality of sections of the inner cylinder comprises a different number of slots, the inner cylinder coaxially disposed within the outer cylinder, wherein the inner cylinder is configured to generate more than one multipole RF field; anda power supply for providing an RF voltage between the outer and inner cylinders for radially confining the ions within the inner cylinder of the at least one ion guide.2. The system of wherein the number of slots is determined by n/2 claim 1 , where n is the order of the multipole RF field generated.3. The system of wherein the number of slots in the plurality of sections of the inner cylinder is selected from the group consisting ...

ION EXTRACTION METHOD FOR ION TRAP MASS SPECTROMETRY

A method is provided for processing ions in a multipole ion trap, comprising generating RF radial confinement fields within a first and second multipole rod set positioned in tandem, a ratio of q value exhibited by the second rod set relative to the first rod set being greater than one for any m/z, said RF axial confinement fields within the first and second rod sets interacting in an interaction region between the first and second rod sets so as to produce a fringing field; transmitting ions through said first rod set towards said second rod set; and increasing the radial oscillation amplitude of at least a portion of the ions within said first rod set such that at least a portion of said ions having an increased radial oscillation amplitude are repulsed by said fringing field.

Method and Apparatus for Analyzing Samples Using Mass Spectrometry

A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds and/or the orientation of those double bonds within the sample molecules. The fragments may include radical fragments and non-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules as confirmation of the presence of those radical fragments.

LIGHT DETECTION DEVICE

A semiconductor light detection element has a plurality of channels, each of which consists of a photodiode array including a plurality of avalanche photodiodes operating in Geiger mode, quenching resistors connected in series to the respective avalanche photodiodes, and signal lines to which the quenching resistors are connected in parallel. A mounting substrate is configured so that a plurality of electrodes corresponding to the respective channels are arranged on a third principal surface side and so that a signal processing unit for processing output signals from the respective channels is arranged on a fourth principal surface side. In a semiconductor substrate, through-hole electrodes electrically connected to the signal lines are formed for the respective channels. The through-hole electrodes and the electrodes are electrically connected through bump electrodes. 16-. (canceled)7. A semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other comprising:a plurality of photodiode arrays, each including a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes, and a signal line to which the quenching resistors are connected in parallel, the quenching resistors and signal line being disposed on the first principal surface side of the semiconductor substrate, anda plurality of through-hole electrodes, each electrically connected to the signal line of the corresponding photodiode array and penetrating the semiconductor substrate.8. The semiconductor light detection element according to claim 7 ,wherein each of the through-hole electrodes is located in a central region of the corresponding photodiode array.9. The semiconductor light detection element according to claim 7 ,{'b': '5', 'wherein each of the through-hole electrodes is located in a region between the ...

LIGHT DETECTION DEVICE

A semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in a semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on a first principal surface side of the semiconductor substrate, and a plurality of through-hole electrodes electrically connected to the quenching resistors and formed so as to penetrate the semiconductor substrate from the first principal surface side to a second principal surface side. A mounting substrate includes a plurality of electrodes arranged corresponding to the respective through-hole electrodes on a third principal surface side. The through-hole electrodes and the electrodes are electrically connected through hump electrodes, and a side surface of the semiconductor substrate and a side surface of a glass substrate are flush with each other. 17-. (canceled)8. A light detection device comprising:a semiconductor light detection element having a semiconductor substrate including first and second principal surfaces opposed to each other;a mounting substrate arranged as opposed to the semiconductor light detection element and having a third principal surface opposed to the second principal surface of the semiconductor substrate; anda light-transmissive substrate arranged as opposed to the semiconductor light detection element and having a fourth principal surface opposed to the first principal surface of the semiconductor substrate,wherein the semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, quenching resistors connected in series to the respective avalanche photodiodes and arranged on the first principal surface side of the semiconductor substrate, and a through-hole electrode electrically connected to the quenching resistors and penetrating the semiconductor substrate,wherein the mounting substrate includes a first ...

Optimized Electromagnetic Field On Side-On FT-ICR Mass Spectrometers

Improvements to a side-on Penning trap include a feedback system for stabilizing the magnetic field. This system includes a magnetic sensor that measures the magnetic field and a solenoid coil that in response to the magnetic field measurements increases or decreases the overall magnetic field. Improvements also include a number of different configurations of the two sets of PCB electrodes used to produce the quadrupole electric field. Dimensions of the PCB electrodes are optimized, an equipotential surface electrode is added, and additional ring electrodes are added to produce a purer quadrupole field. A central disk electrode is segmented to direct charged particles to the trap center to make the trap useful for applications other than mass spectrometry. Finally, outer ring electrodes are segmented to increase the path of charged particles, thereby increasing sensitivity. 1. A side-on injection Penning trap that includes feedback control for stabilizing the magnetic field applied to charged particles , comprising:a first printed circuit board on which is printed a first set of two or more concentric circular or semi-circular electrodes;a second printed circuit board on which is printed a second set of two or more concentric circular or semi-circular electrodes that correspond in size and shape to the first set of electrodes, wherein the second printed circuit board is placed in parallel with the first printed circuit board so that the second set of electrodes faces and is coaxial with the first set of electrodes, wherein the space between the first set of electrodes and the second set of electrodes is a cylindrical gap used to trap charged particles, and wherein the first set of electrodes and the second set of electrodes apply a quadrupole electric field to the cylindrical gap;at least one permanent magnet that is placed coaxially with the first set of electrodes and the second set of electrodes but outside of the cylindrical gap that applies a first magnetic ...

Light detection device

A photodetecting device includes a semiconductor photodetecting element including a plurality of pixels distributed two-dimensionally and a mount substrate including a plurality of signal processing units arranged to process output signals from the corresponding pixels. The semiconductor photodetecting element includes, for each of the pixels, a plurality of avalanche photodiodes arranged to operate in Geiger mode, a plurality of quenching resistors each electrically connected in series with a respective avalanche photodiodes, and a through-electrode electrically connected to the plurality of quenching resistors. Each of the signal processing units includes a current mirror circuit electrically connected to the plurality of avalanche photodiodes via the corresponding through-electrode and arranged to output a signal corresponding to output signals from the plurality of avalanche photodiodes. The number of signal processing units included on the mount substrate is more than the number of light receiving regions in each of the pixels.

Fourier transform ion cyclotron resonance mass spectrometry

Methods and systems for analyzing ions in a magnetic ion trap are provided herein. In accordance with various aspects of the present teachings, the methods and systems described herein enable Fourier transform ion cyclotron resonance mass spectrometry across relatively narrow gap magnetic fields substantially perpendicular to the axis along which the ions are injected into the ion trap. As a result, smaller, less expensive magnets can be used to produce the high-intensity, uniform magnetic fields utilized in high performance FT-ICR/MS applications. Accordingly, the present teachings enable permanent magnets (as well as electromagnets) to generate these magnetic fields, potentially reducing the cost, size, and/or complexity of the systems described herein relative to conventional FT-ICR systems.

PHOTODETECTOR DEVICE

A photodetector device includes an avalanche photodiode array substrate formed from compound semiconductor. A plurality of avalanche photodiodes arranged to operate in a Geiger mode are two-dimensionally arranged on the avalanche photodiode array substrate. A circuit substrate includes a plurality of output units which are connected to each other in parallel to form at least one channel. Each of the output units includes a passive quenching element and a capacitative element. The passive quenching element is connected in series to at least one of the plurality of avalanche photodiodes. The capacitative element is connected in series to at least one of the avalanche photodiodes and is connected in parallel to the passive quenching element. 1. A photodetector device comprising:an avalanche photodiode array substrate in which a plurality of avalanche photodiodes arranged to operate in a Geiger mode are two-dimensionally arranged, the avalanche photodiode array substrate being formed from compound semiconductor; anda circuit substrate on which the avalanche photodiode array substrate is mounted,wherein the circuit substrate includes a plurality of output units connected to each other in parallel to form at least one channel,each of the output units includes a passive quenching element connected in series to at least one of the plurality of avalanche photodiodes, and a capacitative element connected in series to at least one of the avalanche photodiodes and connected in parallel to the passive quenching element.2. The photodetector device according to claim 1 ,wherein the passive quenching element is formed by a first polysilicon layer provided in the circuit substrate,the capacitative element is formed by a second polysilicon layer provided in the circuit substrate, a dielectric layer stacked on the second polysilicon layer, and a third polysilicon layer stacked on the dielectric layer, andthe first polysilicon layer is formed at the same height as in the second ...

Light detection device

A photodetecting device includes a semiconductor substrate, a plurality of avalanche photodiodes each including a light receiving region disposed at a first principal surface side of the semiconductor substrate, the avalanche photodiodes being arranged two-dimensionally at the semiconductor substrate, and a through-electrode electrically connected to a corresponding light receiving region. The through-electrode is provided in a through-hole penetrating through the semiconductor substrate in an area where the plurality of avalanche photodiodes are arranged two-dimensionally. At the first principal surface side of the semiconductor substrate, a groove surrounding the through-hole is formed between the through-hole and the light receiving region adjacent to the through-hole. A first distance between an edge of the groove and an edge of the through-hole surrounded by the groove is longer than a second distance between the edge of the groove and an edge of the light receiving region adjacent to the through-hole surrounded by the groove.

Methods and Systems for Analyzing Proteins Via Electron Capture Dissociation

Methods and systems are provided herein for selectively removing product ions resulting from an ECD dissociation event from the interaction region of an ECD reaction cell, while other precursor peptide ions continue to undergo ECD within the interaction region, thereby reducing or preventing the occurrence of multiple electron capture events by the product ions. In some aspects, the preferential extraction of product ions from the interaction region during the ECD reaction can occur without an auxiliary AC field being generated within the interaction region. Additionally, in some aspects, the methods and systems disclosed herein can subject the various product ions to a non-dissociative charge reduction via exposure to reagent ions of the opposite polarity so as to selectively concentrate product ions to a lower charge state. 1. A system for analyzing ions , comprising:a first set of electrodes at least a first segment of which is arranged in a quadrupole orientation about a first central axis, wherein said first segment of the first set of electrodes extends axially along said first central axis from a proximal inlet end to a distal end so as to define a first portion of a first pathway extending along said first central axis, said proximal inlet end for receiving precursor ions from an ion source and reagent ions of the opposite polarity from the precursor ions from a charged species source;a second set of electrodes at least a first segment of which is arranged in a quadrupole orientation about the first central axis so as to define a second portion of the first pathway, wherein said first segment of the second set of electrodes extends axially along said first central axis from a proximal end to a distal outlet end, the proximal end of the second set of electrodes being spaced apart from the distal end of the first set of electrodes such that a transverse pathway extends between the proximal end of the second set of electrodes and the distal end of the first set ...

Electro Static Linear Ion Trap Mass Spectrometer

One or more ions are received along a central axis through a first set of reflectron plates of an ELIT. Voltages are applied to the first set of plates and to a second set of reflectron plates in order to trap and oscillate the one or more ions. A first induced current is measured from a cylindrical pickup electrode between the first set of reflectron plates and the second set of reflectron plates. A second induced current is measured from one or more plates of the first set of reflectron plates. A third induced current is measured from one or more plates of the second set of reflectron plates. The first measured induced current, second measured induced current and third measured induced current are combined to reduce higher order frequency harmonics of the induced current. 1. An electrostatic linear ion trap for measuring induced current of one or more ions and reducing higher order frequency harmonics of the induced current by combining the induced current with measurements from reflecting reflectron plates , comprising:a first set of reflectron plates with holes in the center that are coaxially aligned along a central axis, wherein the first set of plates includes a first inlet plate followed by a first plurality of reflection plates followed by a first plurality of trapping plates;a cylindrical pickup electrode positioned so that a first end of the pickup electrode is adjacent to the first inlet plate of the first set of plates and the pickup electrode is coaxially aligned with the first set of plates along the central axis;a second set of reflectron plates with holes in the center that are coaxially aligned with the pickup electrode along the central axis, wherein the second set of plates includes a second inlet plate followed by a second plurality of reflection plates followed by a second plurality of trapping plates and wherein the second set of plates is positioned so that the second inlet plate is adjacent to a second end of the cylindrical pickup electrode ...

Process for polishing non-electrolysis nickel plate, alumite or aluminium surface of a memory hard disc

A composition for polishing a layer of non-electrolysis nickel plating, an alumite layer or an aluminium substrate in a memory hard disc comprises water, a polishing agent of aluminium oxide, and a polishing accelerator comprising nickel nitrate or aluminium nitrate or both nickel nitrate and aluminium nitrate, or nickel sulfate and aluminium nitrate.

Polishing composition

A composition for polishing a plastic product, a layer of non-electrolysis nickel plating, an alumite layer or an aluminum product comprises water, a polishing agent of aluminum oxide and a polishing accelerator of nickel sulfate, and is neutral or weak acid.

Process for polishing surface of memory hard disc

A composition for polishing a layer of non-electrolysis nickel plating, an alumite layer or an aluminium substrate in a memory hard disc, the composition comprising water, a polishing agent of aluminium oxide, and a polishing accelerator of one of nickel nitrate and aluminium nitrate, or two compounds, nickel nitrate and aluminium nitrate, or two compounds, nickel sulfate and aluminium nitrate.

Method for Top Down Proteomics Using ExD and PTR

A dissociation device fragments a precursor ion, producing at least two different product ions with overlapping m/z values in the dissociation device. The dissociation device applies an AC voltage and a DC voltage creating a pseudopotential that traps ions below a threshold m/z including the at least two product ions. The dissociation device receives a charge reducing reagent that causes the trapped at least two product ions to be charge reduced until their m/z values increase above the threshold m/z set by the AC voltage. The increase in the m/z values of the at least two product ions decreases their overlap. The at least two product ions with increased m/z values are transmitted to another device for subsequent mass analysis by applying the DC voltage to the dissociation device relative to a DC voltage applied to the other device. 1. Apparatus for reducing the charge of a product ion , comprising:a reagent source device that supplies charge reducing reagent; anda dissociation device that receives a precursor ion, dissociates the precursor ion, producing a plurality of product ions in the dissociation device, receives the charge reducing reagent from the reagent source device, applies an alternating current (AC) voltage to one or more electrodes of the dissociation device that creates a pseudopotential in an axial direction to trap product ions of the plurality of product ions with m/z values below a threshold m/z value in the dissociation device and to, in turn, cause the trapped product ions to be charge reduced by the received charge reducing reagent so that an m/z value of at least one product ion of the trapped product ions increases above the threshold m/z2. The apparatus of claim 1 , wherein the charge reducing reagent source device comprises a proton transfer reaction (PTR) reagent source device claim 1 , the charge reducing reagent comprises PTR reagent ions claim 1 , and the dissociation device applies the AC voltage to the one or more electrodes of the ...

Disc brake

パルプ蒸解助剤組成物

(57)【要約】 【課題】 パルプ蒸解助剤として有用な高濃度アントラ キノン水スラリー液を提供する。 【解決手段】 平均粒径１０μｍ以下、最大粒径３０μ ｍ以下のアントラキノン類の粉体、アニオン界面活性 剤、アルコキシポリアルキレングリコール（メタ）アク リレートとアルキル（メタ）アクリレートを必須成分と してなる共重合物である非イオン界面活性剤および水を 必須の構成要素とするアントラキノン水スラリー液であ るパルプ蒸解助剤組成物。

電子源

(57)【要約】 【課題】 ラダー状に形成されたグリッド電極における 電子線の集束を防ぎ、窓箔にかかる熱負荷を低減して窓 箔の寿命を延ばすことのできる電子源を提供すること。 【解決手段】 シールド電極３内の電子放出開口３ａ （３ｂ）と対向する平面位置に、電子放出開口３ａ（３ ｂ）の長手方向にフィラメント４ａ（４ｂ）が配列さ れ、シールド電極３の電子放出開口３ａ（３ｂ）に、電 子放出開口３ａ（３ｂ）の長手方向に棒状のグリッド電 極５ａ（５ｂ）がラダー状に配列された電子源であっ て、前記ラダー状のグリッド電極列の列方向に伸び各グ リッド電極５ａ（５ｂ）と中央部で交叉する互いに間隔 を隔てて平行に配置した望ましくは３本の棒状のグリッ ド電極９ａ、９ｂ、９ｃを設け、電子放出開口３ａの長 手方向及び幅方向の電界の染み込みを抑制して電子線の 幅を広げる。

Intake chute

Piston-cylinder device and disc brake system using it

High-speed fluidic device

A high-speed fluidic device has a friction roller type speed-increasing mechanism, an electric motor, and a high-speed fluidic machine, wherein: the friction roller type speed-increasing mechanism includes a housing, a low-speed side member having an outer ring provided at one end portion thereof, a high-speed side shaft rotatably supported by the housing so as to be eccentric to the low-speed side member and the outer ring, at least one guide roller rotatably supported between the outer ring and the high-speed side shaft, and at least one movable roller rotatably supported between the outer ring and the high-speed side shaft; the electric motor drives the friction roller type speed-increasing mechanism; and the high-speed fluidic machine is connected to the high-speed side shaft so as to be driven by the high-speed side shaft.

Exhaust gas purifying catalyst and manufacturing method therefor

Dieser Katalysator umfasst eine untere katalytische Schicht 2 mit einer katalytischen Fähigkeit, HC und CO zu oxidieren, und eine obere katalytische Schicht 3 mit einer katalytischen Fähigkeit, NOx zu reduzieren. Die untere katalytische Schicht 2 enthält Pt und Pd, die als katalytische Metalle dienen, Zeolith, ein Ce-haltiges Oxid und aktiviertes Aluminiumoxid, und die obere katalytische Schicht 3 enthält aktiviertes Aluminiumoxid, das ein Rh-dotiertes Ce-haltiges Oxid lädt, und ein NOx-Speichermaterial. This catalyst comprises a lower catalytic layer 2 having a catalytic ability to oxidize HC and CO, and an upper catalytic layer 3 having a catalytic ability to reduce NOx. The lower catalytic layer 2 contains Pt and Pd serving as catalytic metals, zeolite, a Ce-containing oxide and activated alumina, and the upper catalytic layer 3 contains activated alumina charging a Rh-doped Ce-containing oxide, and NOx storage material.

Electrophotographic planographic printing plate

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Am radio receivers

DEVICE FOR REMOVING SOLID DEPOSIT FROM THE INTERIOR SURFACE OF REVOLUTIONS

Optical sensor

A photodetecting device includes a semiconductor substrate including a first principal surface and a second principal surface that oppose each other and a plurality of through-electrodes penetrating through the semiconductor substrate in a thickness direction. The semiconductor substrate includes a plurality of avalanche photodiodes arranged to operate in Geiger mode. The plurality of through-electrodes are electrically connected to the corresponding avalanche photodiodes. The semiconductor substrate includes a first area in which the plurality of avalanche photodiodes are distributed in at least a first direction and a second area in which the plurality of through-electrodes are distributed two-dimensionally. The first area and the second area are distributed in a second direction orthogonal to a first direction when viewed from a direction orthogonal to the first principal surface.

Focus detecting apparatus jointly employing outputs of plural diverse detectors

In an automatic focusing apparatus, a focus detecting device having detecting means for detecting the width of the edge part of the image of an object to be photographed and discriminating means for discriminating a focused state on the basis of the size of the detected width is arranged to determine by the discriminating means the apparatus to be out of focus when the width of the edge part of the object image is wide and to be in focus when the width of the edge part is narrow, so that the focus detecting device can operate without being affected by difference in the kind and the contrast of the object to be photographed.

Mass spectrometer and mass analysis methods

Es wird ein Tandem-Massenspektrometrieverfahren angegeben, das es ermöglicht, in einer Quadrupolionenfalle Produkt-Ionen mit kleiner Massezahl zu erfassen, ohne dass die Empfindlichkeit und die Auflösung verringert sind. In dieser Quadrupolionenfalle werden Ionen durch eine Ionenquelle (1) erzeugt. Dann werden die Ionen in einem dreidimensionalen elektrischen Quadrupolfeld gesammelt, das durch ein Paar von Endkappenelektroden (7) und einer Ringelektrode (8) erzeugt wird. Schließlich werden die angesammelten Ionen isoliert und einer Dissoziation unterzogen, woraufhin sie erfasst werden. In dieser Quadrupolionenfalle sind ein Mechanismus zum Einstrahlen von Laserlicht und ein Mechanismus zum Erzeugen eines elektrischen Hilfswechselfelds während der Dissoziation von Ionen vorhanden. Darüber hinaus wird dafür gesorgt, dass die Richtung des elektrischen Hilfswechselfelds und die Einstrahlrichtung des Laserlichts miteinander übereinstimmen. A tandem mass spectrometry method is specified which makes it possible to detect product ions with a small mass number in a quadrupole ion trap without the sensitivity and the resolution being reduced. In this quadrupole ion trap, ions are generated by an ion source (1). Then the ions are collected in a three-dimensional quadrupole electric field generated by a pair of end cap electrodes (7) and a ring electrode (8). Finally, the accumulated ions are isolated and subjected to dissociation, after which they are detected. In this quadrupole ion trap there is a mechanism for irradiating laser light and a mechanism for generating an auxiliary electrical field during the dissociation of ions. In addition, it is ensured that the direction of the auxiliary electrical alternating field and the direction of incidence of the laser light match each other.

Semiconductor optical detection device

【課題】光学的なクロストークをより一層確実に抑制する半導体光検出装置を提供する。【解決手段】半導体基板３は、互いに対向する第１主面及び第２主面と、行列状に２次元配列されている複数のセルと、を有している。各セルは、ガイガーモードで動作する少なくとも１つのアバランシェフォトダイオードＡＰＤを含んでいる。半導体基板３には、半導体基板３を貫通するトレンチ３４が、第１主面に直交する方向から見て各セルを囲むように形成されている。遮光部材６は、複数のセルのうちの互いに隣り合うセルを光学的に分離する。遮光部材６は、トレンチの第１主面での開口端とトレンチの第２主面での開口端との間で半導体基板３の厚み方向に延在している第１部分と、第２主面から突出している第２部分と、を有している。絶縁膜７が、第２部分を覆っている部分を有している。【選択図】図５

Inline ion reaction device cell and method of operation

A method and apparatus for conducting ion to charged species reactions, more particularly reactions wherein the charged species is an electron, such as ECD. The apparatus comprises first and second pathways which are orthogonal to one another. The first pathway through which ions are introduced comprises multiple multipoles with a gap situated there between. The second pathway introduces the charged species through the gap orthogonally to the first pathway. In this way, a cross-type reaction device allows ion-charged species interactions to occur.

Ion injection method into side-on ft-icr mass spectrometers

Improvements to a side-on Penning trap include methods to stabilize ions in the trap. The ions are stabilized by injecting ions in the focusing region of the non-uniform DC fields produced by the pad electrodes of the trap. Ions are injected along an injection axis shifted from the central axis of a gap between a positively biased electrode pad and negatively biased electrode pad of the trap. Improvements also include methods to compensate for the Lorentz force that is produced when ions are injected into a side-on Penning trap. Electrodes of an ion injection device are DC biased so that the electrodes produce an electric field along the axis of the device that compensates for the Lorentz force. Finally, methods are provided to increase the m/z range of ions injected into a side-on Penning trap by pre-trapping ions just before injection of the ions into the trap.

Catalyzed particulate filter

A filter is configured for efficient combustion of particulates accumulated on a catalyst layer 7 in both a rapid combustion range and a slow combustion range. The catalyst layer 7 on an exhaust gas passage wall of a filter 1 includes a mixture of a Rh-doped Ce-containing composite oxide particle material loaded with Pt and a composite particle material loaded with Pt. In mixed particles of this mixture, Zr-containing composite oxide particles containing no Ce and activated alumina particles are mixed together and agglomerated.

Thermosensitive recording material

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Ion trapping mass spectrometry method and apparatus therefor

An ion trapping mass spectrometer permitting highly sensitive mass spectrometry through in-situ observation. The mass spectrometer comprises ion trapping electrodes, a laser device for generating a cooling laser beam and a photo detector. The ion trapping electrodes generate a field in which to store sample ions and laser-cooled probe ions concurrently. The ions are cooled by laser as well as by the effect of sympathetic cooperative cooling, whereby intense resonance scattering light is acquired from the probe ions. An analyzing AC electric field is applied to the sample ions while the field is being scanned in frequency. Resulting changes in the resonance scattering light and spatial distribution of the probe ions are observed for mass spectrometry.

Mass spectrometer

An electron capture dissociation device to implement a combination of electron capture dissociation and collision dissociation and a mass spectrometer with the use thereof are provided. This device includes a linear ion trap provided with linear multipole electrodes applied with a radio frequency electric field and wall electrodes that are arranged on both ends in the axis direction of the linear multipole electrodes, have holes on the central axis thereof, and generate a wall electric field by being applied with a direct-current voltage, a cylindrical magnetic field-generating unit that generates a magnetic field parallel to the central axis of the linear multipole electrodes and surrounds the linear ion trap, and an electron source arranged opposite to the linear multipole electrodes with sandwiching one of the wall electrodes. The electron generation site of the electron source is placed in the inside of the magnetic field generated by the magnetic field-generating unit.

Electron beam throttling for electron capture dissociation

In one aspect, an electron-ion reaction module, e.g., an electron capture dissociation module, for use in a mass spectrometer is disclosed, which comprises a chamber, an electron source for generating electrons and introducing the electrons into the chamber, a gate electrode positioned relative to the electron source and the chamber, and a DC voltage source operatively coupled to the gate electrode for applying control voltages to the gate electrode. The electron-ion interaction module can further include a controller operably coupled to the DC voltage source and configured for adjusting the DC voltage applied to the gate electrode to adjust flow of electrons into the chamber.

Mass spectrometer

Long-chain unsaturated fatty acid menthol ester and its production by enzyme method

(57)【要約】 【課題】 高度不飽和脂肪酸とメントールとのエステル 合成法を提供すること。 【解決手段】 メントールと、炭素数16以上の長鎖不飽 和脂肪酸またはそのアルキルエステルとをリパーゼの存 在下で反応させ、生成した長鎖不飽和脂肪酸メントール エステルを回収することを含む、長鎖不飽和脂肪酸メン トールエステルの製造方法、並びにこのようにして得る ことができる式（I）および式（II）（式中、R 1 はγ-リ ノレン酸、アラキドン酸、エイコサペンタエン酸または ドコサヘキサエン酸のアシル基部分である)の高度不飽 和脂肪酸メントールエステル。 【化１】 【化２】

Band pass extraction from an ion trapping device and tof mass spectrometer sensitivity enhancement

A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping AC voltage and a DC voltage. A radial dipole DC voltage is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to a lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. Alternatively, a radial RF trapping voltage amplitude is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set.

Mass spectrometer

A method of performing a high sensitivity mass analysis is described wherein a plurality of linear quadrupole radio frequency electrodes are aligned, and operated as a mass filter or an ion trap mass analyzer. A background ion removal filter having a linear quadrupole electrode structure may also be connected in cascade to this mass analyzer if necessary. The background ion removal filter powerfully removes background ions so as to improve analytical sensitivity. This mass spectrometer also makes it possible to prevent losses of minute amounts of sample ions in the ion trap, prevent destruction of minute amounts of ions and reduce contamination of the ion trap electrodes.

changeover switch

【課題】短絡が起きにくい切替開閉器の提供。【解決手段】負荷を含む負荷系統に対して電気を供給する電源を第１の電源系統又は第２の電源系統に切り替える切替開閉器であって、第１の電源系統からの電力が入力される第一側端子部と、第２の電源系統からの電力が入力される第二側端子部と、第一側端子部に入力された第１の電源系統からの電力、又は第二側端子部に入力された第２の電源系統からの電力を負荷系統に出力する負荷側端子部と、を備え、前記第一側端子部と、前記第二側端子部と、前記負荷側端子部のそれぞれの配置エリアは、正面視において異なる場所に設定されている。【選択図】図２

Mass-spectrometer and method for mass-spectrometry

Ion guide for mass spectrometry

An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice. A deflection plate is disposed within the enclosure between the proximal and distal ends and deflects at least a portion of the gas flow away from a central direction of the gas flow. A plurality of electrically conductive, elongate elements extend from the proximal end to the distal end within the enclosure and generate an electric field via a combination of RF and DC electric potentials. The electric field deflects the entrained ions away from the central direction of the gas flow proximal to the deflection plate and confines the deflected ions in proximity of the elongated elements as the ions travel downstream.

Semiconductor light detection element

Mass spectrometer

The present invention provides a mass spectrometry capable of high-efficiency and high-throughput electron capture dissociation (ECD). An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput /high-efficiency ECD.

Mass spectrometer

There is provided a tandem mass spectrometry that, in a quadrupole ion trap, allows small mass-number product ions to be detected without lowering the sensitivity and the resolution. In the quadrupole ion trap, ions are produced by an ion source. Next, the ions are accumulated within a 3-dimensional quadrupole electric field formed by a pair of endcap electrodes and a ring electrode. Finally, the accumulated ions are isolated and dissociated, then being detected. In this quadrupole ion trap, there are provided a mechanism for introducing a laser light, and a mechanism for generating a supplemental alternating-current electric field at the time of the ion dissociation. Moreover, the direction of the supplemental alternating-current electric field and the introduction direction of the laser light are made identical to each other.

Coordinate detecting device and coordinate detection method

(57)【要約】 【課題】 より精度の良い座標値を出力し得る座標検出 装置および座標検出方法を提供すること。 【解決手段】 １０３は、センサー部１０１からの基本 座標値１０２をハードウエア回路により補正およびノイ ズ除去する処理回路である。かかる処理回路１０３は、 基本座標値１０２の内、Ｘ軸方向の座標データに対応す るものと、Ｙ軸方向の座標データに対応するものの２系 統が、内部において独立して準備されている。また、各 系統毎に、補正およびノイズ除去のためのパラメータを 設定できるようになっている。

Electron induced dissociation devices and methods

A method and apparatus for conducting reactions between precursor ions and reagent ions, for example, a reaction between a precursor cation and an electron, such as ECD, are disclosed. The apparatus comprises first, second, and third pathways, each of which extends at least partially along a central axis, and wherein the second central axis is orthogonal to the first and third central axes. Charged species can be introduced into the second pathway as the ions are transmitted therethrough, thereby increasing precursor ion and charged species interaction without simultaneous trapping of the species.

Ion guide device, ion reactor, and mass analyzer

This invention relates to a sequence structure analysis of a biopolymer using a mass analysis method. A time of not less than 10 msec is necessary for a charged particle reaction, and this poses a problem that coupling with a high speed analysis part such as a quadrupole mass filter causes a lowering in throughput or mass separation capability. Accordingly, a charge particle reaction, which can be coupled with the high speed analysis part, should be carried out while regulating an ion residence time to ensure the reaction time. A charged particle reaction cell comprising a plurality of ring electrodes (1) placed side by side is provided. A modulated high frequency voltage obtained by modulating the amplitude of a high frequency voltage is applied. In this case, ions are captured on the bottom of ups and downs of the formed pseudo potential, and the movement thereof causes ion migration. In the charged particle reaction cell, the time necessary for the charged particle reaction can be ensured. Further, the problem of lowered throughput and mass separation capability can be solved, and, thus, the speed of the structure analysis of a measurement sample can be accelerated.

Method for preventing deterioration of processed food

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Catalyzed solid filter

Ein Filter ist zur wirksamen Verbrennung von Feststoffen, die sich auf einer Katalysatorschicht 7 ansammeln, sowohl in einem Schnellverbrennungsbereich als auch in einem langsamen Verbrennungsbereich konfiguriert. Die Katalysatorschicht 7 an der Abgaskanalwand eines Filters 1 umfasst ein Gemisch von einem Rh-dotierten, Ce-enthaltenden Verbundoxidteilchenmaterial, das mit Pt beladen ist, und einem Verbundteilchenmaterial, das mit Pt beladen ist. In den Mischteilchen dieses Gemisches sind Zr-enthaltende Verbundoxidteilchen, die kein Ce enthalten, und aktivierte Aluminiumoxidteilchen miteinander gemischt und agglomeriert.

Photodetector device

Multiplexed precursor isolation for mass spectrometry

Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected. N groups of the N precursor ions are created. The tandem mass spectrometer is instructed to perform multiplexed precursor ion selection on the continuous beam of ions, fragment each of the N−1 precursor ions, and measure the intensities of the product ions, producing N product ion spectra. A heat map is plotted, producing N heat maps. The N product ion spectra are combined into a combined product ion spectrum. A corresponding precursor ion of a peak is identified by finding a heat map of the N heat maps that does not have data for the mass of the peak and determining that a precursor ion of the N precursor ions that is not included in a group that produced the heat map is the corresponding precursor ion.