09-03-2017 дата публикации
Номер: US20170066835A1
Принадлежит:
The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen CD6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-monoclonal antibody for the diagnosis and treatment of Autoimmune Diseases, particularly the Rheumatoid Arthritis. 1. A composition comprising an antiCD6 monoclonal antibody that recognizes human leukocyte differentiation antigen CD6 and does not inhibit the binding of CD6 to ALCAM , wherein the antiCD6 monoclonal antibody is T1h and produced by secreting hybridoma IOR-T1A deposited with the ECACC as deposit No. ECACC 96112640 , and wherein the antiCD6 monoclonal antibody is in a therapeutic amount to cause at least 60% depletion of CD6+ lymphocytes within about 7 weeks in a subj ect.2. The composition of further comprising a pharmaceutical carrier.3. The composition of claim 1 , further comprising an anti-inflammatory agent. This application is a continuation application of copending U.S. patent application Ser. No. 14/252,002, filed on Apr. 14, 2014, which in turn is a divisional application of copending U.S. patent application Ser. No. 12/525,442 filed on Dec. 9, 2009 and claiming priority thereto which in turn is an application filed under 35 U.S.C. §371 claiming priority of International Patent Application No. PCT/CU2007/000021 filed on Dec. 24, 2007, which in turn claims priority of Cuban Application No. 2006-0250 filed on Dec. 26, 2006, the contents of which are incorporated by reference herein for all purposes.The present invention is related to the human medicine and especially with the generation of pharmaceutical compositions comprising a humanized monoclonal antibody recognizing the leukocyte differentiation antigen CD6, and particularly with therapeutic formulations which contain a humanized ...
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