NOVEL CANNABIS SATIVA LINES AND EXTRACTS WITH ANTI-CANCER PROPERTIES

The present invention provides new unique lines, extracts and methods for their use in anti-cancer therapies and modalities. The method includes generation of unique lines, whole plant extract preparation, treating cancer cells and normal cells with extracts in amounts sufficient to kill cancer cells while sparing normal ones. The modulation of cell proliferation, growth and death results in efficient elimination of cancer cells. 1. A method for treating a mammalian disease , the method comprising:a) combining at least one marijuana cultivar and at least one hemp cultivar to form at least one hybrid line;b) extracting at least one compound from said at least one hybrid line to form an extract; andc) administering at least one of said at least one compound and said extract in at least one of in vivo and in vitro to treat, slow or cure said mammalian disease.2. A method according to claim 1 , wherein said at least one hybrid line is selected from the group consisting of a marijuana/marijuana hybrid line claim 1 , hemp/hemp hybrid line and hemp/marijuana hybrid line.3. A method according to claim 2 , wherein said at least one hybrid line is selected from the group consisting of hybrid number CD10 claim 2 , 4 claim 2 , 10 claim 2 , 18 claim 2 , 20 claim 2 , 24 claim 2 , 28 claim 2 , 30 claim 2 , 33 claim 2 , 40 claim 2 , 41 and 81.4. A method according to claim 1 , wherein said extracting step comprises extracting flowers of said at least one hybrid line.5. A method according to claim 4 , wherein said extracting step comprises extracting flowers in at least one organic solvent.6. A method according to claim 5 , wherein said extracting step is performed at a temperature in the range of 15 to 60° C. and at a pressure in a range of −0.5 to +1.5 bar.7. A method according to claim 1 , wherein said mammalian disease is a proliferative mammalian disease.8. A method according to claim 7 , wherein said proliferative mammalian disease is selected from the group consisting of ...

NOVEL CANNABIS LINES AND EXTRACTS WITH ANTI-INFLAMMATORY POTENCIES

The present invention provides new unique cannabis lines, extracts and methods for their use in anti-inflammatory therapies and modalities. The method includes generation of unique lines, whole plant extract preparation, treating normal human 3D tissues with UV to induce inflammation, and then with extracts in amount sufficient to profoundly down-regulate inflammation and molecular pathways involved in rheumatoid arthritis (RA), irritable bowel disease (IBD) and other auto-inflammatory disorders. The modulation of these pathways is a key to treatment success in RA, IBD and the other auto-inflammatory disorders. 1. A method for treating inflammation , the method comprising:a) combining at least one marijuana or hemp cultivar and at least one other marijuana or hemp cultivar to form at least one Cannabis line;{'i': 'Cannabis', 'b) extracting at least one compound from said at least one line to form an extract; and'}c) treating at least one of a mammalian subject and an in vitro model with at least one of said extract and said at least one compound in an effective amount to treat said inflammation.2. A method according to claim 1 , wherein said treating step comprises providing an effective amount of said extract or said at least one compound to said mammalian subject or to said in vitro model to modulate gene expression.3. A method according to claim 1 , wherein said modulation of gene expression comprises modulating at least one gene selected from the group consisting of: a TNF pathway gene claim 1 , a TNI-R gene claim 1 , an Interleukin gene claim 1 , a chemokine gene claim 1 , a gene associated with an inflammatory disease claim 1 , a gene associated with an inflammatory disorder claim 1 , a gene associated with a leukocyte claim 1 , a gene associated with a body joint claim 1 , a gene associated with synovial fluid claim 1 , a gene associated with intestine claim 1 , and combinations thereof.4. A method according to claim 3 , wherein said modulation of gene ...

NOVEL CANNABIS LINES AND EXTRACTS FOR SKIN REJUVENATION AND SKIN PROTECTION

The present invention provides new Cannabis lines, extracts and methods for skin rejuvenation and healing and protection against harmful environmental factors such as UV rays and other damaging agents. The method includes generation of unique lines, whole plant extract preparation, exposing human 3D skin tissues to UV and treating human 3D skin tissues with extracts in amount sufficient to modulate gene expression in the skin tissues before and after UV exposure. The modulation of gene expression then results in a reduction of the disease state-associated changes or aspects thereof in the cannabis-treated skin tissues.

NOVEL CANNABIS LINES AND EXTRACTS FOR TREATING SKIN DISORDERS

The present invention provides cannabis lines, extracts and methods for the treatment of inflammatory skin disorders such as psoriasis, eczema, melanoma skin cancer, and others. The method includes generation of unique lines, whole plant extract preparation, treating human 3D skin tissues and disease models with extracts in amount sufficient to modulate gene expression in the skin tissues. The modulation of gene expression then results in a reduction of the disease state-associated changes or aspects thereof in the treated skin tissues. 1. A method for treating mammalian skin , the method comprising:{'i': 'Cannabis', 'a) combining at least one marijuana or hemp cultivar and at least one other marijuana or hemp cultivar to form at least one line;'}{'i': 'Cannabis', 'b) extracting at least one compound from said at least one line to form an extract; and'}c) treating skin with at least one of said extract and said at least one compound in an effective amount to treat said skin.2. A method according to claim 1 , wherein said treating step induces modulation of gene expression in at least one of skin cells and skin tissue; and wherein said modulation of gene said expression results in a reduction of at least one of a skin disease state claim 1 , an inflammatory state claim 1 , a skin disorder state claim 1 , a poor skin appearance state claim 1 , a skin aging state and combinations thereof.3Cannabis. A method according to claim 1 , wherein said at least one line is selected from the group consisting of a marijuana/marijuana hybrid line claim 1 , hemp/hemp hybrid line and hemp/marijuana hybrid line.4. A method according to claim 3 , wherein said at least one line is selected from the group consisting of designated lines #4 claim 3 , #6 claim 3 , #8 claim 3 , #13 claim 3 , #14 and #18 claim 3 , #5 claim 3 , #31 claim 3 , #39 claim 3 , #49 claim 3 , #69 claim 3 , #114 claim 3 , #166 claim 3 , #267 claim 3 , #273.5Cannabis. A method according to claim 1 , wherein said ...

Use of cd200 protein and cd200 fusion protein in preparing a drug for treating psoriasis

A use of a CD200 extracellular domain protein or a fusion protein formed from a CD200 extracellular domain protein and an Fc fragment in preparing a drug for treating psoriasis is disclosed.

Novel cannabis sativa lines and extracts with anti-cancer properties

The present invention provides new unique cannabis lines, extracts and methods for their use in anti-cancer therapies and modalities. The method includes generation of unique lines, whole plant extract preparation, treating cancer cells and normal cells with extracts in amounts sufficient to kill cancer cells while sparing normal ones. The modulation of cell proliferation, growth and death results in efficient elimination of cancer cells.

Fusion protein and application thereof

The present disclosure provides a fusion protein including Annexin A5 and one or more cell-penetrating peptides. The fusion protein can be used for treating autoimmune disease.

一种计算机用连接线

实用新型公开了一种计算机用连接线，涉及计算机技术领域，具体为一种计算机用连接线，包括连接头，所述连接头表面的中部固定套接有安装板，所述连接头的两侧固定安装有拔插板，所述连接头的一端固定安装有数据连接板，所述连接头的内腔活动套接有螺纹固定柱，所述连接头的另一端固定连接有数据传输线。该计算机用连接线，通过防护弹簧和支撑板的配合，在使用该连接线时，利用防护弹簧对支撑板进行支撑，进而使支撑板对数据连接板进行保护，避免数据连接板在使用时遭到碰撞导致损坏的问题，提高了该计算机用连接线的稳定性，延长了该计算机用连接线的使用寿命。

一种离心喷雾干燥机的出料机构

本实用新型公开了一种离心喷雾干燥机的出料机构，包括输送板，所述输送板的底部四角均焊接有支柱，所述输送板的顶部固定安装有伸缩电机，所述伸缩电机的输出轴上焊接有滑动座，所述滑动座滑动安装在输送板的顶部，所述滑动座的顶部焊接有支架，所述支架的顶部转动安装有转盘，所述滑动座上开设有转动腔，所述转动腔靠近伸缩电机的一侧内壁上固定安装有旋转电机，所述旋转电机的输出轴上焊接有第一锥形齿轮，所述转动腔的底侧内壁上转动安装有转动杆，所述转动杆上焊接有第二锥形齿轮，第二锥形齿轮与第一锥形齿轮相啮合。本实用新型便于自动出料，提高效率，结构简单，使用方便。

Fusion protein and application thereof

The present disclosure relates to a fusion protein including Annexin A5 and one or more cell-penetrating peptides. The fusion protein can be used for treating hemorrhage, vascular injury, blood-brain barrier damage and inflammatory-related diseases of the central or peripheral system.

Novel cannabis lines and extracts for skin rejuvenation and skin protection

The present invention provides new Cannabis lines, extracts and methods for skin rejuvenation and healing and protection against harmful environmental factors such as UV rays and other damaging agents. The method includes generation of unique lines, whole plant extract preparation, exposing human 3D skin tissues to UV and treating human 3D skin tissues with extracts in amount sufficient to modulate gene expression in the skin tissues before and after UV exposure. The modulation of gene expression then results in a reduction of the disease state-associated changes or aspects thereof in the cannabis-treated skin tissues.

Use of CD200 protein and CD200 fusion protein in preparing a drug for treating psoriasis