03-10-2013 дата публикации
Номер: US20130259902A1
Принадлежит:
The present invention relates to a carrier material and bone forming cells, which material is capable of providing treating orthopaedic conditions. In particular, the present invention relates to a bone forming carrier material comprising an anti-inflammatory amount of allogenic bone gel and a bone forming amount of bone-forming cells. 1. (canceled)2. A bone forming carrier material comprising allogenic bone gel and a bone forming amount of bone forming cells , wherein the gel provides at least a 3 fold reduction in the number of polymorphonuclear leukocytes in a subject's tissue.3. The bone forming carrier material of claim 2 , wherein said bone-forming cells are selected from the group consisting of osteoblasts claim 2 , mesenchymal stem cells and progenitor cells or combinations thereof.4. The bone forming carrier material of claim 2 , wherein said bone-forming cells are autologous cells.5. The bone forming carrier material of claim 2 , wherein the bone-forming cells are purified or substantially purified cells that express one or more genes selected from the group consisting of collagen type I claim 2 , osteopontin and osteocalcin.6. The bone forming carrier material of claim 2 , wherein the bone-forming cells are purified or substantially purified osteoblasts.7. The bone forming carrier material of claim 2 , wherein said bone-forming cells comprise about 10-10bone forming cells.8. A medical device coated with the bone forming carrier material of .9. A method of treating an orthopeadic condition comprising the step of administering the bone forming carrier material of .10. A method of inducing bone formation in vivo comprising the steps of:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'a. providing the bone forming carrier material of ; and'}b. applying said carrier material to a site requiring new bone formation.11. A method of treating an orthopeadic condition comprising the step of administering the medical device of . The present invention relates to ...
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