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Применить Всего найдено 4. Отображено 4.
11-12-2013 дата публикации

A pharmaceutical composition comprising an HDAC inhibitor and a steroid and the use thereof.

Номер: CN103442715A
Автор: Drott Kristina, Relander Thomas
Принадлежит:

The invention relates to a pharmaceutical composition comprising a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereofand a steroid or a pharmaceutically acceptable salt thereof as well use of said pharmaceutical composition for the treatment of cancer as a pretreatment prior to other treatments. Said HDAC inhibitor or steroid may alternatively be administrated separately prior to additional treatments.

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Номер записи: 1
03-04-2014 дата публикации

A PHARMACEUTICAL COMPOSITION COMPRISING A HDAC INHIBITOR AND A STEROID AND THE USE THEREOF

Номер: US20140093565A1
Автор: Drott Kristina, Relander Thomas
Принадлежит: VALCURIA AB

The invention relates to a pharmaceutical composition comprising a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereof and a steroid or a pharmaceutically acceptable salt thereof as well use of said pharmaceutical composition for the treatment of cancer as a pretreatment prior to other treatments. Said HDAC inhibitor or steroid may alternatively be administrated separately prior to additional treatments. 1. A pharmaceutical composition comprisinga. a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereof andb. a steroid or a pharmaceutically acceptable salt thereof.2. The pharmaceutical composition according to claim 1 , wherein the HDAC inhibitor is a hydroxamic/carbamic acid claim 1 , a cyclic peptide claim 1 , an aliphatic acid or a benzamide compound.3. The composition according to claim 2 , wherein the HDAC inhibitor is selected from the group consisting of vorinostat claim 2 , romidepsin claim 2 , valproic acid claim 2 , aspanobinostat claim 2 , panobinostat claim 2 , belinostat claim 2 , entinostat and resminostat.4. The composition according to claim 3 , wherein the HDAC inhibitor is selected from the group consisting of valproic acid or valproate semisodium claim 3 , sodium valproate or magnesium valproate.5. The composition according to claim 1 , wherein the steroid is selected from the group consisting of prednisone claim 1 , prednisolone claim 1 , dexamethasone or betamethasone.6. The composition according to claim 5 , wherein the steroid is prednisone.7. The composition according to claim 1 , wherein the HDAC inhibitor is valproic acid and the steroid is prednisone.8. The composition according to claim 1 , further comprising a pharmaceutically acceptable additive claim 1 , diluent claim 1 , carrier claim 1 , excipient or buffer.9. The composition according to claim 1 , which is selected from the group consisting of granulates claim 1 , powders claim 1 , tablets claim 1 , coated ...

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Номер записи: 2
22-09-2016 дата публикации

PHARMACEUTIC COMPOSITION COMPRISING OF HDAC INHIBITOR AND A STEROID AND THE USE THEREOF

Номер: US20160271146A1
Автор: Drott Kristina, Relander Thomas
Принадлежит:

A pharmaceutical composition comprises a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereof and a steroid or a pharmaceutically acceptable salt thereof as well use of said pharmaceutical composition for the treatment of cancer as a pretreatment prior to other treatments. Said HDAC inhibitor or steroid may alternatively be administrated separately prior to additional treatments. 1. A method of pretreating a human being suffering from cancer by administrating a pharmaceutical composition comprising:a. a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereof, andb. a steroid or a pharmaceutically acceptable salt thereof.2. A method of pretreating a human being suffering from cancer by administrating a HDAC inhibitor , a pharmaceutically acceptable acid or a salt thereof or a mixture thereof and a steroid or a pharmaceutically acceptable salt thereof for the pretreatment of cancer , simultaneously or sequentially.3. The method according to claim 1 , wherein the administering a pharmaceutical composition is followed by a chemotherapy and/or immunotherapy.4. The method according to claim 1 , wherein the cancer is selected from the group consisting of sarcoma claim 1 , malignant melanoma claim 1 , skin cancer claim 1 , estrogen receptor-dependent and independent breast cancer claim 1 , ovarian cancer claim 1 , prostate cancer claim 1 , renal cancer claim 1 , colon and colorectal cancer claim 1 , pancreatic cancer claim 1 , head and neck cancer claim 1 , small cell and non-small cell lung carcinoma claim 1 , and cancer of blood cells.5. The method according to claim 4 , wherein the cancer is selected from the group consisting of diffuse large B cell lymphoma (DLBCL) claim 4 , follicular lymphoma claim 4 , chronic lymphocytic leukaemia claim 4 , T-cell lymphoma claim 4 , myeloma and Hodgkin lymphoma.6. A method of evaluating a substance effect on the CHOP-sensitivity of cell lines claim 4 , comprising ...

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Номер записи: 3
12-05-2020 дата публикации

A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof.

Номер: CA2829263C
Автор: Kristina DROTT, Thomas RELANDER
Принадлежит: VALCURIA AB

The invention relates to a pharmaceutical composition comprising a HDAC inhibitor, a pharmaceutically acceptable acid or a salt thereof or a mixture thereofand a steroid or a pharmaceutically acceptable salt thereof as well use of said pharmaceutical composition for the treatment of cancer as a pretreatment prior to other treatments. Said HDAC inhibitor or steroid may alternatively be administrated separately prior to additional treatments.

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Номер записи: 4