Pre-filled plastic syringes and containers and method of terminal sterilization thereof

Disclosed is a pre-filled plastic syringe containing a liquid product for terminal sterilization comprising: a syringe barrel equipped with a one-way valve and a slidable plunger to equalize pressure differentials; a filter engaging the one way valve to prevent backward migration of viruses and bacteria; an end cap covering the open end of the barrel to maintain sterility; and an end cap restraining device to prevent plunger blow-out.

Pre-filled plastic syringes and containers and method of terminal sterlization thereof

ABSTRACT Disclosed is a pre-filled plastic syringe containing a liquid product for terminal sterilization comprising: a syringe barrel equipped with a one-way valve and a slidable plunger to equalize pressure differentials; a filter engaging the one way valve to prevent backward migration of viruses and bacteria; an end cap covering the open end of the barrel to maintain sterility; and an end cap restraining device to prevent plunger blow-out.

Plastic syringe filled in advance with a liquid sterilizabe substance

Předem naplněná plastová injekční stříkačka (10), zásobník nebo lékovka obsahující kapalnou látku (12) pro konečnou sterilizaci, sestává z nádobky (20) opatřené jednocestným zpětným ventilem (30) a posuvným pístem (50) pro vyrovnávání tlakových rozdílů, podle potřeby osazeného filtračního nástavce (40) nasazeného na zpětný ventil (30) pro zamezení zpětné migrace virů a bakterií, z koncového uzavíracího kloboučku (60), uzavírajícího otevřený konec nádobky (20) pro udržování sterility, a z přidržovacího přípravku (80) pro zamezení vytlačení pístu (50) z nádobky (20).ŕ The pre-filled plastic syringe (10), container or vial containing the liquid substance (12) for final sterilization consists of a container (20) provided with a one-way non-return valve (30) and a displacement piston (50) to compensate for pressure differences as required by the mounted filter extensions (40) mounted on a non-return valve (30) to prevent the migration of viruses and bacteria, from an end cap (60) closing the open end of the sterility maintenance container (20) and from the retaining means (80) to prevent piston displacement (50) ) from the container (20)

SYRINGES, CONTAINERS AND PLASTIC VIALS PREVIOUSLY FILLED AND METHOD OF TERMINAL STERILIZATION THEREOF.

A pre-filled plastic syringe (10), container or vial containing a liquid product for terminal sterilization comprising: a barrel (20) equipped with a one-way valve (30) and a slidable plunger (50) to equalize pressure differentials; an optional filter (40) engaging the one way valve to prevent backward migration of viruses and bacteria; an end cap (60) covering the open end (26) of the barrel to maintain sterility; and an end cap restraining device (80) to prevent plunger blow-out is described. <IMAGE>

Pre-filled plastic syringe containing liquid sterilisable substance

The plastic syringe is accommodated for final sterilisation together with its filling and this sterilisation is provided in the autoclave, while this syringe consists of the vessel (20) containing the substance to be sterile (12), and of the front part of which is located the nozzle (24) towards an application place used for jetting of the substance to be sterilled, of the piston (50) which is located in the vessel, so that it is able to be moved, when acting to it via pressure and it is located on the contrary rear end, when this vessel is being filled. On the nozzle (24), there is located the one way valve (30), in a direction of the vessel (20) body permeable over the overpressure of inside the vessel (20). The closure of the rear end (26) is created by the closing cap (60), which is equipped with basis (62) with a sealing towards the extended flange (28) of the opened rear end (26) of the vessel (20) body, with a tighten holding at the rear end (26) with blocking element (80) which is able to be removed, placed on the circuit of the flange (28) round the circuit (64) of the basis (62) opposite the piston (50) ejection of the vessel (20), while on the basis (62) of the closing cap (60), there is created the elastic buffer boss (66), located in the direction inside the vessel (20) made of a compressible material.

Vorgefüllte plastikspritzen, -behälter und - fläschchen und methode zu deren abschliessender sterilisierung