AMINO ALCOHOL DERIVATIVE AND IMMUNOSUPPRESIVE AGENT HAVING SAME AS AN ACTIVE INGREDIENT

An amino alcohol derivative useful as an excellent immunosuppressive agent is provided. As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), has excellent immunosuppressive activity.

THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMYELINATING DISEASE COMPRISING AMINO ALCOHOL DERIVATIVE AS ACTIVE INGREDIENT

A novel therapeutic agent or prophylactic agent for a demyelinating disease is provided. An amino alcohol derivative represented by the general formula (1), which is a sphingosine-1-phosphate receptor agonist, a pharmacologically acceptable salt or hydrates thereof, are a therapeutic agent or prophylactic agent for a demyelinating disease.

THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR INFLAMMATORY BOWEL DISEASE COMPRISING AMINO ALCOHOL DERIVATIVE AS ACTIVE INGREDIENT

A novel therapeutic agent or prophylactic agent for an inflammatory bowel disease is provided. An amino alcohol derivative represented by the general formula (1): which is a sphingosine-1-phosphate receptor agonist or a pharmaceutically acceptable salt or hydrate thereof are a therapeutic agent or prophylactic agent for an inflammatory bowel disease comprises.

Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease

A method for treating a liver disease such as hepatitis, comprising administering to a patient having the liver disease, an effective amount of a diarylsulfide or diarylether derivative having 2-amino-1,3-propanediol structure, and represented by the following formula (1): or a pharmaceutically acceptable salt thereof.

Therapeutic Agent for Treating liver Disease Containing 2-Amino-1,3-Propanediol Derivative as Active Ingredient, and Method for Treating Liver Disease

A novel therapeutic agent for organ disease, in particular, a therapeutic agent for liver disease is provided. It has been found that a diarylsulfide or diarylether derivative having 2-amino-1,3-propanediol structure, the compound that act as a sphingosine-1-phosphate receptor agonist, and a pharmaceutically acceptable salt and hydrate thereof are used as effective therapeutic agents for various diseases in organs, in particular liver diseases. The diarylsulfide or diarylether derivative is represented by the following general formula (1): ...

EFFECTIVE USE METHOD OF MEDICAMENTS AND METHOD OF PREVENTING EXPRESSION OF SIDE EFFECT

To provide a medicament which efficiently expresses an immunosuppressive agent or an anti-inflammatory agent and reduces expression of side effect. A medicament includes diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure having an activity of reducing lymphocytes circulating peripherally, in combination with an immunosuppressive agent and/or an anti-inflammatory agent.

Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient

A novel therapeutic agent or prophylactic agent for an inflammatory bowel disease is provided. An amino alcohol derivative represented by the general formula (1): which is a sphingosine-1-phosphate receptor agonist or a pharmaceutically acceptable salt or hydrate thereof are a therapeutic agent or prophylactic agent for an inflammatory bowel disease comprises.

Therapeutic Agent for Inflammatory Bowel Disease Containing as Active Ingredient 2-Amino-1,3-Propanediol Derivative, or Method for Treating Inflammatory Bowel Disease

A novel therapeutic and prophylactic agent for inflammatory bowel diseases and a method for treating inflammatory bowel diseases. The agent comprises a 2-amino-1,3-propanediol derivative (e.g., 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl-1,3-propanediol hydrochloride) represented by the chemical formula (1) or a pharmaceutically acceptable salt or hydrate thereof: The agent is useful in the treatment or prevention of Crohn's disease, Crohn's disease in large intestine, intestinal Behcet's disease, ulcerative colitis, bleeding rectal ulcer and pouchitis.

Amino alcohol derivative and immunosuppresive agent having same as an active ingredient

An amino alcohol derivative useful as an excellent immunosuppressive agent is provided. As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), has excellent immunosuppressive activity.

Effective use method of medicaments and method of preventing expression of side effect

A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure and having the function of diminishing lymphocytes circulating through the periphery; and an immunosuppressant and/or an anti-inflammatory agent.

Effective use method of medicaments and method of preventing expression of side effect

To provide a medicament which efficiently expresses an immunosuppressive agent or an anti-inflammatory agent and reduces expression of side effect. A medicament includes diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure having an activity of reducing lymphocytes circulating peripherally, in combination with an immunosuppressive agent and/or an anti-inflammatory agent.

Method for treating an inflammatory bowel disease using 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl-1,3-propanediol or a salt thereof

A novel therapeutic and prophylactic agent for inflammatory bowel diseases and a method for treating inflammatory bowel diseases is provided. The agent comprises a 2-amino-1,3-propanediol derivative (e.g., 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl-1,3-propanediol hydrochloride) represented by the chemical formula (1) or a pharmaceutically acceptable salt or hydrate thereof: The agent is useful in the treatment or prevention of Crohn's disease, Crohn's disease in large intestine, intestinal Behcet's disease, ulcerative colitis, bleeding rectal ulcer and pouchitis.

Effective Use Method Of Medicaments And Method Of Preventing Expression Of Side Effect

A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure and having the function of diminishing lymphocytes circulating through the periphery; and an immunosuppressant and/or an anti-inflammatory agent.

An amine alcohol derivative and an immunosuppressive agent for use as an active ingredient

Method of effectively using medicine and method concerning prevention of side effect

Aminoalcohol derivative and immunosuppressant containing the same as active ingredient

Disclosed are (R)-2-amino-2-methyl-alkan-1-ols as represented by the general formula (1a) wherein R3 represents a straight chain alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom , and n denotes 2 or 3; or a pharmaceutically acceptable salt or hydrate thereof. Of particular importance are the compounds (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenoxy)phenyl]-2-methylpentan-1-ol, (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, (R)-2-amino-4-[2-chloro-4-(3-trifluoromethylphenoxy)phenyl]-2-methylbutan-1-ol, (R)-2-amino-4-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylbutan-1-ol and (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-propylpentan-1-ol and pharmaceutically acceptable salts or hydrates thereof. Further disclosed is a pharmaceutical which comprises an amino alcohol derivative, or a pharmaceutically acceptable salt or hydrate thereof as defined above as an active ingredient for the prevention or treatment of rejection reactions in organ transplants or bone marrow transplants, or for use as an immunosuppressive agent.

Therapeutic agent for inflammatory bowel disease comprising 2-amino-1,3-propanaediol derivative as active ingredient, and method for treatment of inflammatory bowel disease

Therapeutic agent for inflammatory bowel disease comprising 2-amino-1,3-propanaediol derivative as active ingredient, and method for treatment of inflammatory bowel disease

Amino alcohol derivative and immunosuppressive agent having same as an active ingredient

An amino alcohol derivative useful as an excellent immunosuppressive agent is provided. As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), (see formula 1) has excellent immunosuppressive activity.

Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient

US Disease Therapeutic Agent Containing 2-Amino-1,3-Propanediol Derivative as an Active Ingredient

Παρέχεται ένας πρωτότυπος θεραπευτικός παράγοντας νόσου οργάνων, ειδικότερα ένας θεραπευτικός παράγοντας για ηπατική νόσο. Ανακαλύφθηκε ότι ένα διαρυλσουλφίδιο ή διαρυλαιθερικό παράγωγο με 2-αμινο-1,3-προπανοδιολική δομή, η ένωση που δρα σαν αγωνιστής του υποδοχέα σφιγγοσίνο-1-φωσφορικού και ένα φαρμακευτικώς αποδεκτό άλας και υδρίτης αυτού χρησιμοποιούνται σαν αποτελεσματικοί θεραπευτικοί παράγοντες για διάφορες νόσους σε όργανα, ιδιαίτερα δε ηπατικές νόσους. Το διαρυλσουλφίδιο ή διαρυλαιθερικό παράγωγο αναπαρίσταται με τον ακόλουθο γενικό τύπο (1): A novel organ disease therapeutic agent is provided, in particular a therapeutic agent for liver disease. It has been found that a diarylsulfide or diaryl ether derivative with a 2-amino-1,3-propanediol structure, the compound acting as a sphingosine-1-phosphate receptor agonist and a pharmaceutically acceptable salt and hydrate thereof are used as effective therapeutic agents. , especially liver diseases. The diarylsulfide or diaryl ether derivative is represented by the following general formula (1):

Therapeutic agent for inflammatory bowel disease containing as active ingredient 2-amino-1,3-propanediol derivative, or method for treating inflammatory bowel disease

Disclosed is a 2-amino-1,3-propanediol derivative represented by the formula (1) (e.g., 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl- 1,3-propanediol hydrochloride), which is a sphingosine-1-phosphate receptor agonist, or a pharmaceutically acceptable salt or solvate thereof. It is found that the derivative, salt or solvate is useful as a therapeutic agent or a prophylactic agent for an inflammatory bowel disease such as Crohn~s disease, Crohn~s disease of large intestine, intestinal Behcet~s disease, ulcerative colitis, hemorrhagic rectal ulcer or pouchitis.

Aminoalcohol derivative and immunosuppressant containing the same as active ingredient.

Lo que se describe es un derivado de aminoalcohol útil como un excelente inmunosupresor. Se describe, de manera específica, un derivado de aminoalcohol representado por la fórmula general (1) a continuación, el cual es un compuesto altamente seguro que tiene una excelente actividad inhibidora inmune.

Therapeutic agent for inflammatory bowel disease comprising 2-amino-1,3-propanaediol derivative as active ingredient, and method for treatment of inflammatory bowel disease.

Un agente terapéutico y profiláctico novedoso para enfermedades inflamatorias intestinales y un método para tratar enfermedades inflamatorias intestinales. El agente comprende un derivado de 2-amino-1,3-propanodiol (por ejemplo, clorhidrato de 2-amino-2-[4-(3-benciloxifeniltio)-2-clorofenil]etil-1,3-propanod iol) representado por la fórmula química (1) o una sal o hidrato farmacéuticamente aceptable del mismo (ver fórmula (1)): El agente es útil en el tratamiento o la prevención de enfermedad de Crohn, enfermedad de Crohn en intestino grueso, enfermedad intestinal de Behcet, colitis ulcerativa, úlcera hemorrágica rectal y bursitis.

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