22-09-2022 дата публикации
Номер: US20220296549A1
Active components comprising lauric acid, or a lauric acid derivative, are utilized independently, or in combination, to provide new and useful compositions for bacteriostatic action against susceptible pathogens. The lauric acid derivative includes one or more of 12-aminododecanoic acid, 12-amino-1-dodecanoic acid methyl ester, sucrose monolaurate, 12-(7-nitrobenzofurazan-4-ylamino) dodecanoic acid, 4-nitrophenyl dodecanoate, 1-lauroyl-rac-glycerol, 3-oxo-N-(2-oxocyclohexyl) dodecanamide, butyl laurate, benzyl laurate, isoamyl laurate, monolaurin, isopropyl laurate, pentyl laurate, and hexyl laurate. A preparation includes combining the active component with lecithin, and after an initial processing phase, coating with chitosan or a carrier. Final compositions may be or may contain particles, such as nanoparticles. Final compositions, or formulations containing said final compositions, may be utilized internally, causing one or more membrane changes (e.g., a membrane of an internal target pathogen, which may or may not be an antibiotic-resistant pathogen). At least some compositions inhibit growth of one or more Gram-positive bacterial species and one or more Gram-negative bacterial species. 1. A composition having broad spectrum antimicrobial action comprising:a lauric acid derivative as an active component of the composition, the lauric acid derivative being one of a strongly hydrophobic 12-carbon chain fatty acid and a strongly hydrophobic 12-carbon chain fatty acid ester, each having one or more carbon-containing side chains, in which each lauric acid derivative also has a partition coefficient, P, and to be strongly hydrophobic its log P value will be less than 4; andlecithin components containing phospholipids and at least one bulky fatty acid having a carbon chain length from between about 14 and 20, and in an amount up to about 50 wt. % of the composition,wherein the composition is in a form of nanoparticles, and is suitable for utilization in a formulation ...
Подробнее
