18-09-2014 дата публикации
Номер: US20140273273A1
Принадлежит:
The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (HF) based on the detection of NT-proBNP, troponin T, and/or a natriuretic peptide. Also disclosed are methods for improving both the accuracy and speed of HF risk models by incorporating biomarker data from patient samples. 1. A method for diagnosing heart failure risk in a subject , comprising:a. obtaining the subject's simplified model factors;b. obtaining the amount of Troponin T (TnT) and NT-pro B-type natriuretic peptide (NT-proBNP) in a biological sample obtained from the subject;c. obtaining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;d. obtaining the alignment value of the simplified model score compared to a clinical model score; ande. providing a diagnosis of heart failure risk if the alignment value exceeds a threshold.2. A method for identifying a subject as in need of therapy for heart failure , comprising:a. obtaining the subject's simplified model factors;b. contacting a portion of a biological sample obtained from the subject with an antibody immunoreactive for Troponin T (TnT);c. contacting a portion of the biological sample obtained from the subject with an antibody immunoreactive for a NT-pro B-type natriuretic peptide (NT-proBNP);d. determining an amount of TnT and an amount of NT-proBNP in the biological sample obtained from the subject;e. determining a simplified model score based on the amount of TnT and NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors;f. comparing the simplified model score to a clinical model score to determine an alignment value; andg. identifying the subject as in need of therapy for heart failure if the alignment value is above a threshold.4. A method of selecting a treatment for a ...
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