20-08-2020 дата публикации
Номер: US20200261606A1
Принадлежит:
Methods of and systems for making a hyperpolarized fluid are provided, which include exposing a fluid and parahydrogen to a catalyst. The hyperpolarized fluid can be introduced to a subject. The hyperpolarized fluid can be included in methods of imaging a subject. Also provided are methods that use the hyperpolarized fluids for detecting protein ligand interactions and for enhancing the NMR signals of biopolymers having chemically exchangeable protons. 1. A method of making a hyperpolarized fluid , comprising:exposing a fluid and parahydrogen to a catalyst, where the fluid is a liquid or a gas; andmaking hyperpolarized fluid upon the interaction of the fluid, the parahydrogen, and the catalyst.2. The method of claim 1 , wherein the exposing comprises one of:mixing the fluid with the catalyst to produce a fluid-catalyst mixture and dissolution of parahydrogen into the fluid-catalyst mixture;dissolving the parahydrogen with the fluid to form a fluid-parahydrogen mixture and mixing the fluid-parahydrogen mixture with the catalyst; orexposing the fluid in a vapor state and parahydrogen to the catalyst to form a hyperpolarized fluid in a vaporized state.34-. (canceled)5. The method of claim 1 , wherein making the hyperpolarized fluid comprises condensing the hyperpolarized fluid as a hyperpolarized solid.6. (canceled)7. The method of claim 1 , wherein the fluid is selected from the group consisting of: a —OH containing molecule claim 1 , a molecule containing an amide or an amino group claim 1 , an amino acid claim 1 , a sugar claim 1 , a carboxylic acid claim 1 , or a combination thereof.8. The method of claim 7 , wherein the —OH containing molecule is selected from the group consisting of: water claim 7 , methanol claim 7 , ethanol claim 7 , propanol claim 7 , and a combination thereof.9. (canceled)10. The method of claim 1 , wherein the fluid is selected from the group consisting of: methylamine claim 1 , ammonia claim 1 , ethaneamide claim 1 , methanamide claim 1 , ...
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