Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1) A three-dimensional printing equipment assembly comprising:a) a three-dimensional printing build system comprising:a conveyor system adapted to conduct plural build modules;plural build modules engaged with the conveyor system, wherein the build modules are adapted to receive and temporarily retain powder from a powder layering system; andat least one build station comprising: 1) at least one powder layering system adapted to form incremental powder layers within build modules; and 2) at least one printing system adapted to apply a liquid according to a predetermined pattern to incremental powder layers within build modules;wherein the conveyor system repeatedly transports the build modules from the at least one powder layering system to the at least one printing system to form a three-dimensionally printed bed comprising one or more three-dimensionally printed articles in the build modules; and the equipment assembly excludes a printing system adapted to apply liquid to the powder according to a polar coordinate algorithm.2) The assembly of comprising:a) a three-dimensional printing build system comprising:a conveyor system adapted to conduct plural build modules and comprising positioning-controller and plural build module engagements;plural build modules engaged with the conveyor system, wherein the build modules are adapted to receive and temporarily retain powder from a ...

THREE-DIMENSIONAL PRINTING SYSTEM AND EQUIPMENT ASSEMBLY

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1177-. (canceled)178. A build module for a three-dimensionally printing apparatus , comprising a height adjustable platform and a removable build plate disposed above the height adjustable platform , wherein the removable build plate has a plurality of perforations.1791. The build module according to claim , wherein the plurality of perforations are evenly spaced.1802. The build module according to claim , wherein the surface of the removable build plate is smooth.1812. The build module according to claim , wherein the surface of the removable build plate is roughened.1821. The build module according to claim , wherein the surface of the removable build plate is smooth.1831. The build module according to claim , wherein the surface of the removable build plate is roughened.1841. The build module according to claim , wherein the shape of the removable build plate is a rectangle with rounded corners.1851. The build module according to claim , wherein the shape of the removable build plate is a rectangle with one convex end.1861. The build module according to claim , wherein the shape of the removable build plate has a bullet-shaped profile.1871. The build module according to claim , further including one or more sidewalls surrounding the height adjustable platform and the build plate , and defining a cavity within which the height adjustable platform incrementally raised or lowered.188 ...

RAPIDLY-ORODISPERSIBLE TABLETS HAVING AN INTERIOR CAVITY

A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside. 1. A rapidly-orodispersible dosage form comprising a porous , durable body comprising a bound-powder material , the body having one or more interior empty cavities , preferably wherein the bound-powder material comprises an interconnected porous matrix of at least one ingestible powder material and at least one ingestible binder material.2. The rapidly-orodispersible dosage form according to claim 1 , the interconnected porous matrix consists of adjacent particles of the at least one ingestible powder material that are connected and bonded together by the at least one ingestible binder material that can bind to the particles of the powder material and to other binder material.3. The dosage form according to claim 1 , wherein the ingestible powder material comprises one or more pharmaceutical excipients selected from the group consisting of: a binder claim 1 , a disintegration agent claim 1 , a dispersant claim 1 , a sweetener claim 1 , a glidant claim 1 , a flavoring agent claim 1 , a surfactant claim 1 , a humectant claim 1 , a preservative claim 1 , an antioxidant claim 1 , a solvent claim 1 , ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1) A method of preparing a three-dimensionally printed article , the method comprising:a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the powder comprises at least one binder;b) depositing binding fluid on one or more powder layers within the receptacle to bind particles of the at least one binder and form one or more incremental printed layers;c) before completion of the 3DP article, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system comprising at least one upper punch; andd) repeating steps a) and b), and optionally step c), to complete formation of the 3DP article.2) A method of preparing a three-dimensionally printed article , the method comprising:a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the powder comprises at least one binder;b) depositing binding fluid onto the one or more powder layers to bind particles of the at least one binder and form a printed bed comprising loose unprinted powder and one or more incremental printed layers corresponding to one or more 3DP articles;c) before completion of the one or more 3DP articles, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 174-. (canceled)75) A three-dimensional printing equipment assembly comprising:a circuitous conveyor system that conducts plural build modules along a circuit;plural build modules engaged with the circuitous conveyor system, wherein the plural build modules comprise respective height adjustable platforms and respective removable build plates disposed above the respective height adjustable platforms;at least one build station that forms respective one or more three-dimensionally printed articles on the respective removable build plates; anda bed transfer system that transfers the one or more three-dimensionally printed articles and the respective removable build plates away from the circuitous conveyor.76. (canceled)77. (canceled)78) A three-dimensional printing equipment assembly comprising:a circuitous conveyor system that conducts plural build modules along a circuit;build modules engaged with the circuitous conveyor system, wherein the build modules comprise respective height adjustable platforms and respective removable build plates disposed above the respective height adjustable platforms;at least one build station that forms respective one or more three-dimensionally printed articles on the respective removable build plates;at least one liquid removal system that removes liquid from the one or more three-dimensionally printed articles; anda bed transfer system that transfers ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1134-. (canceled)135) A three-dimensional printing equipment assembly comprising:a circuitous or oscillating conveyor system;plural build modules comprising respective height adjustable platforms;at least one build station that forms respective one or more three-dimensionally printed articles on the plural build modules;a bed transfer system that transfers the one or more three-dimensionally printed articles away from the conveyor system;a control system that determines and specifies the location of one or more of the plural build modules relative to the conveyor system;wherein the conveyor system repeatedly conducts the plural build modules through the at least one build station.136) The equipment assembly of further comprising one or more build module positioning systems claim 135 , one or more conveyor positioning systems or both.137) The equipment assembly of claim 136 , wherein the control system comprises a proximity sensor that specifies the location of one or more of the plural build modules relative to the conveyor system.138) The equipment assembly of further comprising a component that considers at least the linear speed of the conveyor or of the plural build modules when forming the respective one or more three-dimensionally printed articles.139) The equipment assembly of further comprising a control system that determines the location of respective ones of the plural ...

Rapidly Dispersible Dosage Form of Oxcarbazepine

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof. 167-. (canceled)68) A method of preparing a rapidly dispersible porous three-dimensionally printed bound matrix , the method comprising:forming drug-containing particles comprising at least one first disintegrant, at least one first binder, at least one surfactant and native particles of drug, wherein the drug-containing particles have an average, mean or median effective particle size and the native particles of drug have an average, mean or median native particle size, and the ratio of average, mean or median effective particle size to average, mean or median, respectively, native particle size ranges from greater than 1:1 to 200:1;combining at least one second disintegrant and at least one second binder with said drug-containing particles to form a bulk powder; andthree-dimensionally printing said bulk powder to form one or more of said three-dimensionally printed bound matrix.69) The method of claim 68 , wherein the step of forming drug-containing particles comprises granulating the at least one first disintegrant claim 68 , at least one first binder claim 68 , at least one surfactant and native particles of drug.70) The method of claim 68 , wherein the step of three-dimensionally printing comprises forming plural stacked incremental layers of said bulk powder and binding particles of said bulk powder.71) The method of claim 70 , wherein the step of binding comprises depositing printing fluid on one or more of said incremental layers according to one or more predetermined patterns.72) The method of further comprising the step of removing or reducing the amount ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1. A three-dimensional printing equipment assembly comprising:a) a three-dimensional printing build system comprising:a conveyor system that conducts plural build modules along a circuitous path;plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises an incrementally height adjustable platform, a removable build plate disposed above the platform, and one or more sidewalls defining a cavity within which the platform the build plate are disposed; andat least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within build modules; and 2) at least one printing system that applies a liquid according to a predetermined pattern to incremental powder layers within build modules and comprising at least one liquid feed system and at least one print head that deposits liquid according to a predetermined pattern onto incremental layers of powder in a build module;wherein the conveyor system repeatedly transports the build modules from the at least one powder layering system to the at least one printing system to form a three-dimensionally printed bed comprising one or more three-dimensionally printed articles in the build modules.2. The assembly of comprising:a) a three-dimensional printing build system ...

Rapid Disperse Dosage Form Containing Levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 10 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam.

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1) A three-dimensional printing equipment assembly comprising:a) a three-dimensional printing build system comprising:a conveyor system adapted to conduct plural build modules along a circuitous path;plural build modules engaged with the conveyor system, wherein the build modules are adapted to receive and temporarily retain powder from a powder layering system, and wherein a build module comprises an incrementally height adjustable platform, a removable build plate disposed above the platform, and one or more sidewalls defining a cavity within which the platform the build plate are disposed; andat least one build station comprising: 1) at least one powder layering system adapted to form incremental powder layers within build modules; and 2) at least one printing system adapted to apply a liquid according to a predetermined pattern to incremental powder layers within build modules and comprising at least one liquid feed system and at least one print head adapted to deposit liquid according to a predetermined pattern onto incremental layers of powder in a build module;wherein the conveyor system repeatedly transports the build modules from the at least one powder layering system to the at least one printing system to form a three-dimensionally printed bed comprising one or more three-dimensionally printed articles in the build modules.2) The assembly of comprising:a) a three- ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 140.-. (canceled)41) A method for the preparation of three-dimensionally printed articles with an equipment assembly , the method comprising:a) initiating operation of a three-dimensional printing build system comprising:a conveyor system adapted to conduct plural build modules along a circuitous path;plural build modules engaged with the conveyor system, wherein the build modules are adapted to receive and temporarily retain powder from a powder layering system; andat least one build station comprising: 1) at least one powder layering system adapted to form incremental powder layers within build modules; and 2) at least one printing system adapted to apply a liquid according to a predetermined pattern to incremental powder layers within build modules;b) with the conveyor system, repeatedly transporting the build modules from the at least one powder layering system to the at least one printing system to form a three-dimensionally printed bed comprising one or more three-dimensionally printed articles in the build modules.42) The method of further comprising:a) harvesting the one or more three-dimensionally printed articles from the three-dimensionally printed bed with at least one harvesting system adapted to separate loose powder from the one or more three-dimensionally printed articles.43) The method of further comprising removing liquid from one or more incremental powder layers ...

Rapid disperse dosage form

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug.

Rapid Disperse Dosage Form Containing Levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam.

Rapidly Dispersible Dosage Form of Oxcarbazepine

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof. 1) (canceled)2) (canceled)3) (canceled)4) (canceled)5) (canceled)6) (canceled)7) (canceled)8) (canceled)9) (canceled)10) (canceled)11) (canceled)12) (canceled)13) (canceled)14) (canceled)15) A rapidly dispersible porous non-compressed three-dimensionally printed bound matrix comprising:drug-containing particles comprising at least one first disintegrant, at least one first binder, at least one surfactant and native particles of drug, wherein the drug-containing particles have an average, mean or median effective particle size and the native particles of drug have an average, mean or median native particle size, and the ratio of average, mean or median effective particle size to average, mean or median, respectively, native particle size ranges from greater than 1:1 to 200:1;at least one second disintegrant; andat least one second binder;wherein the hardness of the matrix ranges from about 1 to about 7 kiloponds.16) The matrix of claim 15 , wherein the matrix disperses in 15 sec or less when placed in 15 ml of aqueous fluid.17) The matrix of claim 15 , wherein the average native particle size is such that 90%-100% wt of the drug is <10 microns claim 15 , and the ratio of average effective particle size to average native particle size is in the range of 10:1 to 200:1.18) The matrix of claim 15 , wherein the average native particle size is such that not more than 20% wt of the drug is <32 microns claim 15 , 40-70% wt of the drug is <63 microns claim 15 , 70-95% wt of the drug is <125 microns claim 15 , and 100% wt of the drug is <250 microns claim 15 , and the ratio ...

RAPID DISPERSE DOSAGE FORM

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug. 1. A method of three-dimensionally printing a three-dimensionally printed rapidly dispersible dosage form , method comprising:a) depositing an incremental layer of drug-containing powder onto a surface;b) depositing a sufficient amount of printing fluid onto the incremental layer to bind particles in the drug-containing powder, wherein the printing fluid comprises glycerin and at least one pharmaceutically acceptable solvent; andc) repeating a) and b) thereby forming the three-dimensionally printed rapidly dispersible dosage form.2. The method of claim 1 , wherein the pharmaceutically acceptable solvent comprises water or aqueous buffer.3. The method of claim 1 , wherein the pharmaceutically acceptable solvent comprises alcohol and water or aqueous buffer.4. The method of claim 1 , wherein the printing fluid comprises 1-10% wt glycerin claim 1 , 55-95% wt water or aqueous buffer claim 1 , 1-25% wt alcohol.5. The method of claim 1 , wherein the printing fluid further comprises surfactant.6. The method of claim 5 , wherein the printing fluid comprises 0.1-4% wt of surfactant.7. The method of of claim 1 , wherein the printing fluid further comprises water soluble claim 1 , aqueous fluid soluble claim 1 , partially water soluble or partially aqueous fluid soluble binder.8. The method of claim 7 , wherein the printing fluid comprises 1-20% wt water soluble claim 7 , aqueous fluid soluble claim 7 , partially water soluble or partially aqueous fluid soluble binder.9. The method of claim 1 , wherein the printing fluid further comprises flavorant.10. The method of claim 9 , wherein the printing fluid comprises ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1155-. (canceled)156) A three-dimensional printing equipment assembly comprising:a circuitous or oscillating conveyor system;plural build modules comprising respective height adjustable platforms and removable build plates;at least one build station that forms respective one or more three-dimensionally printed articles on the plural build modules;a control system that determines and specifies the location of one or more of the plural build modules relative to the conveyor system;wherein the conveyor system repeatedly conducts the plural build modules through the at least one build station.157) The equipment assembly of further comprising one or more build module positioning systems claim 156 , one or more conveyor positioning systems or both.158) The equipment assembly of claim 157 , wherein the control system comprises a proximity sensor that specifies the location of one or more of the plural build modules relative to the circuitous or oscillating conveyor system.159) The equipment assembly of further comprising a component that considers at least the linear speed of the circuitous or oscillating conveyor or of the plural build modules when forming the respective one or more three-dimensionally printed articles.160) The equipment assembly of further comprising a control system that determines the location of one or more of the plural build modules.161) The equipment assembly of ...

Three-dimensional Printing System and Equipment Assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. 1155-. (canceled)156) A three-dimensional printing equipment assembly comprising:a circuitous or oscillating conveyor system;plural build modules comprising respective height adjustable platforms and removable build plates;at least one build station that forms respective one or more three-dimensionally printed articles on the plural build modules;a control system that determines and specifies the location of one or more of the plural build modules relative to the conveyor system;wherein the conveyor system repeatedly conducts the plural build modules through the at least one build station.157) The equipment assembly of further comprising one or more build module positioning systems claim 156 , one or more conveyor positioning systems or both.158) The equipment assembly of claim 157 , wherein the control system comprises a proximity sensor that specifies the location of one or more of the plural build modules relative to the circuitous or oscillating conveyor system.159) The equipment assembly of further comprising a component that considers at least the linear speed of the circuitous or oscillating conveyor or of the plural build modules when forming the respective one or more three-dimensionally printed articles.160) The equipment assembly of further comprising a control system that determines the location of one or more of the plural build modules.161) The equipment assembly of ...

METHOD AND SYSTEM FOR FORMING A DOSAGE FORM WITHIN A PACKAGING

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging. 2. The method according to claim 1 , wherein the at least one depression has a fixed shape and volume.3. The method according to claim 1 , wherein the packaging comprises a sheet including a plurality of the depressions formed into the sheet claim 1 , and where the sidewall in the depression extends from the sheet to a closed end.4. The method according to claim 1 , wherein step 4) is repeated at least three times.5. The method according to claim 1 , wherein the powder material comprises particles of a binder material claim 1 , and the binding liquid binds the particles of the binder material.6. The method according to claim 1 , further including a step claim 1 , preceding step 2) claim 1 , of depositing an amount of a binding liquid on at least the closed end of the depression.7. The method according to claim 1 , wherein the at least one depression includes an inner surface that includes a release agent.8. The method according to claim 1 , wherein the binding liquid comprises a volatile solvent.9. The method according to claim 8 , further including a step of evaporatively removing claim 8 , after step 3) claim 8 , a portion of the volatile solvent from the incremental first wetted powder layer claim 8 , to ...

Rapidly Dispersible Dosage Form with High Drug Content

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof. 1) A rapidly dispersible solid dosage form comprising a porous non-compressed three-dimensionally printed bound matrix comprising:drug-containing particles having an effective particle size and comprising a first grade of oxcarbazepine (OXC) particles having a first native particle size, a second grade of OXC particles having a second native particle size, at least one disintegrant, at least one surfactant, and at least one binder;at least one disintegrant; andat least one binder; whereinthe dosage form disperses in 15 sec or less when placed in 15 ml of aqueous fluid; andthe ratio of effective particle size to first native particle size is >1:1 to 5:1, and the ratio of effective particle size to second native particle size is 20:1 to 50:1.2) A rapidly dispersible three-dimensionally printed porous non-compressed bound matrix comprising:a first grade of OXC particles having a first native particle size, a second grade of OXC particles having a second native particle size, at least one sweetener, at least one binder, at least one disintegrant, at least one surfactant, and at least one glidant; whereinthe matrix comprises particles bound by binder;the matrix disperses in less than 15 sec in a volume of 15 ml of aqueous fluid;the OXC particles are included in drug-containing particles having an effective particle size and comprising the OXC particles and at least one pharmaceutical excipient as carrier;the content of OXC in the matrix ranges from 35-60% wt based upon the total weight of the matrix; andthe ratio of effective particle size to first native particle size ...

Rapidly Dispersible Dosage Form of Topiramate

A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

Rapidly Dispersible Dosage Form of Topiramate

A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof. 1. A taste-masked rapidly dispersible dosage form comprising a three-dimensionally printed solid porous non-compressed bound matrix comprising:taste-masked wax-coated particles comprising topiramate and at least one waxy material present at a weight ratio ranging from 20:80 to 50:50, respectively, wherein the wax is not an ionic polymer or copolymer, an acrylate polymer or copolymer, a methacrylate polymer or copolymer, or an enteric polymer or copolymer;binder; andsurfactant; wherein,the dosage form disperses in less than 90 sec when placed in aqueous fluid.2. The dosage form of further comprising one or more components selected from the group consisting of disintegrant claim 1 , sweetener claim 1 , diluent claim 1 , glycerin and glidant.3. The dosage form of wherein: a) the wax coated particles of topiramate are prepared by spray congealing a mixture comprising molten wax and particles of topiramate; b) the wax coating comprises one or more claim 1 , one claim 1 , two claim 1 , or three different waxes; c) the surfactant is present in an amount up to 2% wt based upon the final weight of the dosage form; d) the total amount of wax coated particles ranges from 20-50% wt based upon the final weight of the dosage form; e) the hardness of the matrix ranges up to about 1.0 kiloponds; f) binder is introduced into the matrix by way of printing fluid used to form the matrix; g) binder is introduced into the matrix by way of bulk powder used to form ...

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non- pharmaceutical / non-medical objects. It can be used to prepare single or multiple articles.

Rapid disperse dosage form containing levetiracetam.

Se da a conocer una forma de dosificación impresa tridimensioalmente que se dispersa rápidamente de dosis altas que comprende una dosis alta de levetiracetam en una matriz porosa que se dispersa en agua dentro de un período menor que aproximadamente 10 segundos. También se dan a conocer métodos para preparar la forma de dosificación y para tratar una condición, enfermedad o trastorno que es sensible terapéuticamente al levetiracetam. También se proporciona un proceso para preparar la forma de dosificación.

Rapidly dispersible dosage form of topiramate

OF THE DISCLOSURE A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

Rapid disperse dosage form containing levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 10 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam. A process for preparing the dosage form is also provided

Three-dimensional printing system and equipment assembly.

Es proporcionado un sistema de impresión de tres dimensiones y montaje de equipo para la manufactura de artículos impresos de tres dimensiones. El montaje de equipo incluye un sistema incorporado de impresión de tres dimensiones, un sistema opcional de remoción del líquido y un sistema opcional recolector. El sistema incorporado incluye un transportador, múltiples módulos incorporados y al menos una estación incorporada que tiene un sistema de estratificación de polvo y un sistema de impresión. El montaje de equipo puede ser utilizado para manufacturar objetos farmacéuticos, médicos, y no farmacéuticos/no médicos. El montaje puede ser utilizado para preparar artículos únicos o múltiples artículos. La figura más representativa de la invención es la número 1.

Rapidly dispersible dosage form of oxcarbazepine

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperse in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof. FIG.1 1 FIG.2 5 22 > -6 FIG. 3A FIG. 3B FIG. 3C FIG. 3D FIG. 3E FIG. 4A FIG. 4B

Rapidly dispersible dosage form of topiramate

A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non- pharmaceutical / non-medical objects. It can be used to prepare single or multiple articles.

Rapid disperse dosage form containing levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 10 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically response to levetiracetam. A process for preparing the dosage form is also provided.

Direct current energization of gaseous discharge lamps

Rapidly dispersible dosage form of oxcarbazepine

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical / non-medical objects. It can be used to prepare single or multiple articles.

Rapidly dispersible dosage form of oxcarbazepine

Three dimensionally printed dosage forms

Rapidly dispersible dosage form of topiramate

A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

Rapidly dispersible dosage form of oxcarbazepine

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non- pharmaceutical / non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Method and system for forming a dosage form within a packaging

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer, Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Rapid disperse dosage form containing levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 10 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam. A process for preparing the dosage form is also provided

Method and system for forming a dosage form within a packaging

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Forma de dosificacion empacada de multiples componentes y metodo.

Un método y un sistema para hacer una forma de dosificación farmacéutica dentro de una porción de un empaque tipo burbuja. El método incluye los pasos de proporcionar un empaque tipo burbuja para la forma de dosificación con depresiones. Una cantidad predeterminada de un material en polvo que contiene fármaco que comprende partículas que contienen fármaco se deposita en una capa de polvo sustancialmente uniforme dentro de las depresiones. Luego se deposita un líquido aglutinante en un patrón sobre la capa de polvo dentro de las depresiones, para unir las partículas de la capa de polvo y formar una capa de polvo húmeda creciente. El exceso de solvente en el material aglutinante se puede eliminar para formar una capa unida creciente. Estos pasos se repiten en secuencia por lo menos una o más veces para hacer la forma de dosificación farmacéutica dentro del empaque tipo burbuja.

Three-dimensional printing system and equipment assembly

Sistema de impresion de tres dimensiones y montaje de equipo.

Es proporcionado un sistema de impresión de tres dimensiones y montaje de equipo para la manufactura de artículos impresos de tres dimensiones. El montaje de equipo incluye un sistema incorporado de impresión de tres dimensiones, un sistema opcional de remoción del líquido y un sistema opcional recolector. El sistema incorporado incluye un transportador, múltiples módulos incorporados y al menos una estación incorporada que tiene un sistema de estratificación de polvo y un sistema de impresión. El montaje de equipo puede ser utilizado para manufacturar objetos farmacéuticos, médicos, y no farmacéuticos/no médicos. El montaje puede ser utilizado para preparar artículos únicos o múltiples artículos. La figura más representativa de la invención es la número 1.

Three-dimensional printing system and equipment assembly

Sistema de impresion tridimensional y ensamblaje de equipo.

Se proporciona un sistema de impresión tridimensional y un ensamblaje de equipo para la manufactura de artículos impresos tridimensionalmente. El ensamblaje de equipo incluye un sistema de construcción de impresión tridimensional, un sistema de remoción de líquido opcional y un sistema recolector opcional. El sistema de construcción incluye un transportador, numerosos módulos de construcción y por lo menos una estación de construcción que tiene un sistema de estratificación de polvo y un sistema de impresión. El ensamblaje de equipo se puede utilizar para manufacturar objetos farmacéuticos, médicos y no farmacéuticos/no médicos. Se puede utilizar para preparar artículos individuales o múltiples.

Rapidly-orodispersible tablets having an interior cavity

A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.

Tabletas rapidamente orodispersables que tienen una cavidad interior.

Se proporciona una forma de dosificación rápidamente orodispersable que comprende una matriz porosa de polvo unido y una o más cavidades internas, así como también métodos de impresión tridimensional para hacer la misma. Cada cavidad interna se configura para contener una o más cargas útiles, particularmente medicamentos farmacéuticos, mientras que aísla las cargas útiles del ambiente externo fuera de la forma de dosificación. Cada carga útil puede estar contenida dentro de su cavidad en su forma nativa sin tener que ser combinada con la matriz de polvo unido o el líquido aglutinante. Las formas de dosificación pueden desintegrarse en agua o saliva en menos de dos minutos, independientemente de la(s) carga(s) útil(es) o medicamento(s) contenidos en el interior. Las formas de dosificación se pueden formular como tabletas unitarias, o como tabletas de dos piezas que comprenden un cuerpo de recipiente y un cuerpo de tapa que se aseguran juntos para aislar una o más de las cavidades y sus cargas útiles en el interior.

Multi-component packaged dosage form and method

Orodispersive dosage forms containing droxidopa

A rapidly-orodispersible tablet containing a porous, bound powder matrix containing droxidopa. The bound matrix contains an acidulant, particularly citric acid, to delay, reduce, or inhibit the coloration of droxidopa during stress storage conditions, and suppress the effect of glycerin on the coloration of droxidopa-containing tablets. The tablet can be dividable along a functional seam printed into the bound powder matrix, to divide the tablet into sub-dosage units of the same mass of droxidopa.

High strength paper, process of making the same and single - play paper sacks made therefrom

Three-dimensional printing system and equipment assembly

OF THE DISCLOSURE A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/ non-medical objects. It can be used to prepare single or multiple articles.

Metodo y sistema para crear una forma de dosificacion dentro de un empaque.

Se describen un método y un sistema para crear una forma de dosificación farmacéutica dentro de una porción de un empaque de tipo burbuja. El método incluye los pasos de proporcionar un empaque de tipo burbuja para la forma de dosificación con depresiones. Una cantidad predeterminada de un material en polvo que contiene fármaco que comprende partículas que contienen fármaco se deposita en una capa de polvo sustancialmente uniforme dentro de las depresiones. Un líquido adherente luego se deposita en un patrón sobre la capa de polvo dentro de las depresiones, para unir las partículas de la capa de polvo y formar una capa humedecida progresiva. El solvente en exceso en el material adherente puede ser retirado para formar una capa unida progresiva. Estos pasos se repiten en secuencia por lo menos una o más veces para crear la forma de dosificación farmacéutica dentro del empaque de tipo burbuja.

Multi-component packaged dosage form and method

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted powder layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Coil and core structure having means to minimize corona discharge

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Rapid disperse dosage form containing levetiracetam

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam.

Rapidly dispersible dosage form of oxcarbazepine

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Rapidly dispersible dosage form of topiramate

A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.