12-06-2014 дата публикации
Номер: US20140163032A1
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HTserotonin receptor. 3. The compound according to or , wherein V is O.4. The compound according to any one of to , wherein W is —CHCH— optionally substituted with 1 to 2 substituents selected independently from the group consisting of Calkyl and oxo.5. The compound according to any one of to , wherein W is —CHCH— , —CHC(CH)— , or —CHC(═O)—.6. The compound according to any one of to , wherein Z is absent.7. The compound according to any one of to , wherein Z is —CH— or —CHCH—.8. The compound according to any one of to , wherein Ris Calkyl.9. The compound according to any one of to , wherein Ris —CH.10. The compound according to any one of to , wherein Ris H.11. The compound according to any one of to , wherein Ris H , Cl , or Br.12. The compound according to any one of to , wherein Q is —NRR.13. The compound according to claim 12 , wherein Ris H claim 12 ,14. The compound according to claim 12 , wherein Ris Cacyl claim 12 , or carbo-C-alkoxy each optionally substituted with 1 claim 12 , 2 claim 12 , 3 claim 12 , 4 claim 12 , or 5 substituents selected independently from the group consisting of Cacyloxy claim 12 , Calkylcarboxamide claim 12 , amino claim 12 , Calkylamino claim 12 , Cdialkylamino claim 12 , Calkylimino claim 12 , Calkylsulfinyl claim 12 , Calkylsulfonyl claim 12 , Calkylthio claim 12 , halogen claim 12 , nitro claim 12 , and phenyl.15. The compound according to any one of to claim 12 , wherein Ris Calkyl claim 12 , Ccycloalkyl claim 12 , Chaloalkyl claim 12 , heterocyclyl claim 12 , or heteroaryl claim 12 , and each is optionally substituted with 1 claim 12 , 2 claim 12 , 3 claim 12 , 4 claim 12 , or 5 substituents selected independently from the group consisting of Calkoxy claim 12 , Calkyl claim 12 , Calkylsulfonyl claim 12 , amino claim 12 , carbo-C-alkoxy claim 12 , carboxamide claim 12 , cyano claim 12 , ...
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