МЕДИЦИНСКАЯ СИСТЕМА УДАЛЕННОГО МОНИТОРИНГА, АНАЛИЗА И ПРОГНОЗИРОВАНИЯ СОСТОЯНИЯ ПАЦИЕНТА ПО ПОСЛЕДОВАТЕЛЬНОСТИ ЭЛЕКТРОКАРДИОГРАММ СЕРДЦА ПЕРВОГО ОТВЕДЕНИЯ И КОМПЬЮТЕРИЗИРОВАННЫЙ СПОСОБ МОНИТОРИНГА, АНАЛИЗА И ПРОГНОЗИРОВАНИЯ СОСТОЯНИЯ ПАЦИЕНТА

Группа изобретений относится к медицине, а именно к системе и компьютеризированному способу удаленного мониторинга, анализа и прогнозирования состояния пациента по последовательности электрокардиограмм (ЭКГ). При этом для каждого пациента из наблюдаемого множества осуществляют накопление в базе данных последовательности его ЭКГ, маркированных идентификаторами пациента. Выделяют по запросу врача подмножество ЭКГ, которые объединяют в целевую группу по идентификаторам пациента и в соответствии с заданными в запросе врача ограничениями. Осуществляют кластеризацию выделенного подмножества путем объединения ЭКГ в кластер по признаку взаимного подобия их форм. Определяют меру подобия форм в пространстве признаков форм ЭКГ. Каждой ЭКГ ставят в соответствие дискретизированную ЭКГ (ДЭКГ), представляющую собой точку с координатами, значения которых несут информацию о форме исходной ЭКГ. Мера подобия форм между парами ЭКГ задается в виде расстояния между соответствующими им парами точек ДЭКГ. Для ...

Exercise intensity estimation method, exercise intensity estimation device, and program

This exercise intensity estimation device comprises: an RS wave calculation unit (3) that calculates the RS amplitude from the peak value of an R wave to the nadir value of an S wave in an ECG waveform of a subject; a T wave calculation unit (4) that calculates the T wave amplitude in the ECG waveform; a heart rate calculation unit (5) that calculates the heart rate from the ECG waveform; an index calculation unit (6) that calculates, as a first index indicating the exercise intensity of the subject, a T wave amplitude normalized by the RS amplitude; and an index calculation unit (7) that calculates, as a second index indicating the exercise intensity of the subject, values obtained by multiplying the first index by the heart rate.

Machine learning based depolarization identification and arrhythmia localization visualization

Techniques that include applying machine learning models to episode data, including a cardiac electrogram, stored by a medical device are disclosed. In some examples, based on the application of one or more machine learning models to the episode data, processing circuitry derives, for each of a plurality of arrhythmia type classifications, class activation data indicating varying likelihoods of the classification over a period of time associated with the episode. The processing circuitry may display a graph of the varying likelihoods of the arrhythmia type classifications over the period of time. In some examples, processing circuitry may use arrhythmia type likelihoods and depolarization likelihoods to identify depolarizations, e.g., QRS complexes, during the episode.

SINGLE ARM ECG MONITOR

A system for measuring the ECG of a user by having at least two sensors, all of which are attached to only one peripheral of the user. The system may also comprise a controller for determining ECG signals from the data received from the sensors. The system may be in the form of a wearable band on which the sensors and the controller are disposed. The sensors may be capacitive sensors, electrically coupled capacitive sensors, or electrodes. The sensors may be attached to one arm of a user. The sensors may be disposed on the inside and outside of the arm away from each other at the same axial position on the arm. The sensors may be disposed at axially different positions on the arm, for example, one at the wrist and the other at the shoulder of the user.

AN APPARATUS AND A METHOD FOR QT CORRECTION

A method for QT correction is provided, the method comprising receiving an ECG signal; extracting a plurality of beat-to-beat (RR) intervals; extracting a plurality of QT intervals; computing a first probability distribution for a range of QT values based on the plurality of QT intervals; computing a second probability distribution for a range of QT values based on the plurality of QT intervals and the plurality of RR intervals; solving one or more points, wherein the first probability distribution and the second probability distribution intersect or wherein a difference between the first probability distribution and the second probability distribution is below a pre-defined difference threshold; designating one of one or more QT values corresponding to the one or more points as a corrected QT interval for a given QT interval of the plurality of QT intervals.

PACING EFFICACY DETERMINATION USING A REPRESENTATIVE MORPHOLOGY OF EXTERNAL CARDIAC SIGNALS

Systems and methods are described herein for detecting efficiency of pacing using external cardiac signals. A representative electrical signal morphology of the cardiac signals may be determined based on the plurality of electrical signals, and an efficacy of left bundle branch (LBB) engagement determined based on the representative electrical signal morphology.

Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis

A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.

ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS

Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

Blood pressure determinations

Methods and devices for blood pressure monitoring may include receiving one or more sensor measurements from the at least one sensor. The methods and devices may further include determining at least one of a first blood pressure indication using a first regression representation based on the one or more sensor measurements, a second blood pressure indication using a second regression representation based on the one or more sensor measurements, or a third blood pressure indication using a third regression representation based on the one or more sensor measurements. The methods and devices may include performing a blood pressure selection procedure using the first blood pressure indication, the second blood pressure indication, and the third blood pressure indication to determine an estimated blood pressure indication based on one or more classification characteristics. The methods and devices may further include transmitting the estimated blood pressure indication to the output device.

WEARABLE CARDIOVERTER DEFIBRILLATION (WCD) SYSTEM WITH PROXIMATE PROGRAMMING DEVICE WHICH STORES ECG DATA THAT THE WCD SYSTEM NORMALLY DISCARDS

In embodiments, a wearable medical system (WMS) for an ambulatory patient, which can be a wearable cardioverter defibrillator (WCD) system, analyzes the patient's ECG signal to generate a detection outcome. The WMS also has an ambulatory user interface that outputs a human-visible indication. A programming device, such as a PC, a tablet, etc., establishes a communication link with the WMS during an in-person session with the patient. The programming device may include a programming screen that reproduces the human-visible indication in real time. An advantage can be that the person programming the WMS need not strain to look also at the ambulatory user interface at the time they are looking at the programming device. Another advantage can be that the patient will recognize that he or she is better protected, and have their confidence in the WMS increased, and therefore better comply with wearing the WMS as required.

ELECTROCARDIOGRAM WAVE SEGMENTATION USING MACHINE LEARNING

A method includes analyzing a first segment of electrocardiogram measurements corresponding to a first heartbeat and a second heartbeat of a patient to identify a set of features of the first segment of electrocardiogram measurements. The method further includes adjusting the set of features based at least on the first segment and a second segment of electrocardiogram measurements corresponding to the first heartbeat. The method further includes predicting, based on the adjusted set of features, a region in the second segment of electrocardiogram measurements comprising a p-wave generated by the second heartbeat.

Systems and methods for providing and managing a personalized cardiac rehabilitation plan

A system for managing an individualized cardiac rehabilitation plan is provided. The system includes an externally worn device and a server. The server includes a processor configured to receive input regarding the rehabilitation plan; generate one or more plans specifying an individualized set of rehabilitative exercise sessions for a patient, receive electrocardiogram (ECG) and non-ECG physiological information acquired from the patient compare the ECG and/or non-ECG physiological information to predetermined criteria and dynamically adjust the cardiac rehabilitation plan based on the comparison to create an adjusted cardiac rehabilitation plan.

PHYSIOLOGIC EVENT DETECTION AND DATA STORAGE

ИТЕРАЦИОННОЕ КОГЕРЕНТНОЕ КАРТИРОВАНИЕ ЭЛЕКТРОФИЗИОЛОГИЧЕСКОЙ АКТИВАЦИИ СЕРДЦА, ВКЛЮЧАЯ ЭФФЕКТЫ РУБЦА

Группа изобретений относится к медицине, а именно к способу и системе для итерационного когерентного картирования электрофизиологической активации сердца. При этом принимают входное сетчатое представление сердечной камеры, набор измеренных местоположений на ткани стенки сердечной камеры и соответствующий набор значений локального времени активации (LAT), измеренных в указанных местоположениях. Перестраивают входную сетку в правильную сетку, содержащую многоугольники правильной формы. Согласовывают данные набора измеренных местоположений и соответствующих LAT с многоугольниками правильной формы. Осуществляют итерационный расчет для многоугольников правильной формы (i) соответствующих значений LAT и (ii) соответствующих вероятностей содержания рубцовой ткани в ткани стенки так, чтобы получать электрофизиологическую (ЭФ) волну активации на правильной сетке, указывающую на рубцовую ткань. Обеспечивают представление электроанатомической карты, содержащей ЭФ–волну активации и рубцовую ткань, ...

Аппаратно-программный комплекс электрокардиографических измерений

Изобретение относится к медицинской технике. Аппаратно-программный комплекс электрокардиографических (ЭКГ) измерений содержит закрепляемый на пользователе корпус, в котором установлены микроконтроллер, аналого-цифровой преобразователь, средство хранения данных, выполненное с возможностью хранения данных ЭКГ, модуль беспроводной связи, обеспечивающий передачу данных из средства памяти на внешнее вычислительное устройство, первый, второй и третий электроды, аккумулятор и разъем для подключения внешних электродов, обеспечивающих регистрацию ЭКГ. Первый электрод совмещен с емкостной кнопкой, обеспечивающей активацию функции снятия ЭКГ устройством. Второй и третий электроды расположены на тыльной стороне корпуса и обеспечивают совместно с первым электродом регистрацию ЭКГ. Полоса частот амплитудно-частотных характеристик для всех каналов аналоговых интерфейсов составляет 0-4000 Гц с допустимыми отклонениями амплитуд от 0 до 2000 Гц ±10% и частотой дискретизации сигнала 8000 Гц. Микроконтроллер ...

Methods and systems for determining a physiological or biological state or condition of a subject

The present disclosure provides methods, devices, and systems for determining a state or condition of a subject. A method for determining a state or condition of a heart of a subject may include using a monitoring device comprising an electrocardiogram (ECG) sensor and an audio sensor to measure ECG data and audio data from an organ of the subject, and transmitting the ECG data and the audio data wirelessly to a computing device. A trained algorithm may be used to process the ECG data and the audio data to determine the state or condition of the organ of the subject. More specifically, the trained algorithm can be customized for a specific indication or condition. An output indicative of the state or condition of the heart of the subject may be provided on the computing device.

Method and system for measuring and displaying biosignal data to a wearer of a wearable article

An electrocardiogram (ECG) output A is corrected for anomalous heartbeats 1 by obtaining a series of heart rate values, determining when the rate of change of the heart rate values exceeds a threshold, and identifying a selected heartbeat as anomalous if the threshold is exceeded. One or more correcting steps X, X’’ are sequentially applied to the region around the anomalous heart beat, the rate of change of heartrate values determined for each correcting step, and the correcting step corresponding to the lowest rate of change is selected as a permanent correction for that region of the ECG output. The correcting steps may include one or more of removing, inserting or moving the position of a selected heartbeat. The rate of change of heartrate values may be determined for three consecutive heartbeats in the region around the selected heartbeat. An embodiment includes a wearable article with a sensor arrangement to obtain the ECG signal.

METHOD FOR MEASURING HEART RATE VARIABILITY

A system for measuring heart rate variability (HRV) comprising 3 sub-systems: a data collection sub-system, a data analysis sub-system, and an output sub¬ system. A patient is connected to a heart monitoring device such as an ECG and the data collection sub-system records the patient's heart beats, and an ECG chart is produced from which the patient's HRV value is derived by the data analysis sub-system. The present invention obtains the HRV value through calculation of a new parameter called relative density (RD). In accordance with the inventive method, data points are generated from the peak interval data of measured heart beats and the HRV relative density parameter (RD) is calculated by correlation between two subsets of data points.

CARDIAC CONDUCTION SYSTEM THERAPY BENEFIT DETERMINATION

Systems and methods are described herein for determining whether cardiac conduction system pacing therapy may be beneficial and/or determining how proximal or distal a cardiac conduction system block may be using external cardiac signals. To do so, one or more left-sided metrics of electrical heterogeneity information may be generated based on left-sided surrogate cardiac electrical measured using a plurality of left external electrodes ...

Noninvasive method and system for estimating mammalian cardiac chamber size and mechanical function

The present disclosure generally relates to systems and methods and systems of a noninvasive technique for characterizing cardiac chamber size and cardiac mechanical function. A mathematical analysis of three-dimensional (3D) high resolution data may be used to estimate chamber size and cardiac mechanical function. For example, high-resolution mammalian signals are analyzed across multiple leads, as 3D orthogonal (X,Y,Z), or 10-channel data, for 30 to 800 seconds, to derive estimates of cardiac chamber size and cardiac mechanical function. Multiple mathematical approaches may be used to analyze the dynamical and geometrical properties of the data.

Systems and methods for identifying optimized ablation targets for treating and preventing arrhythmias sustained by reentrant circuit

Methods and systems for identifying optimized ablation targets for treating and preventing arrhythmias sustained by reentrant circuits are described. The methods comprise receiving at least one mesh generated from one or more images of a patient's heart, receiving activation data generated from one or more simulations of electrical-signal propagation over the at least one mesh, generating at least one flow graph based on the activation data and the at least one mesh, and applying a max-flow min-cut algorithm to the at least one flow graph to determine at least one of a number, one or more dimensions, and one or more locations of one or more ablation targets. Non-transitory computer-readable media storing a set of instructions for treating and preventing arrhythmias sustained by reentrant circuits are also described.

Способ настройки системы модуляции сердечной сократимости у пациентов с широким комплексом QRS на ЭКГ

Изобретение относится к медицине, а именно к способу настройки системы модуляции сердечной сократимости у пациентов с широким комплексом QRS на ЭКГ. При этом пациенту под местной анестезией имплантируют электрокардиостимулятор (ЭКС) и два эндокардиальных биполярных электрода с активной фиксацией. Электроды имплантируют в межжелудочковую перегородку с минимальным диастазом 2 см и маркируют как LS-электрод и RV-электрод, которым соответствуют LS-канал и RV-канал соответственно. Электроды подключают к наружному программатору для проверки и при соответствии параметров на электродах заданным значениям подключают к ним ЭКС. Настраивают ЭКС с помощью наружного программатора. Подтверждением верной настройки является стабильная стимуляция желудочков, которую оценивают сразу после настройки ЭКС по программатору, где события на LS-канале регистрируют в интервале «Alert», и ЭКГ путем подтверждения в ≥90% случаев нанесения терапии после сердечного сокращения. Подтверждением неверной настройки является ...

Micro-coherence network strength and deep behavior modification optimization application

A subjects Default Mode Network is accessed through corresponding measurements of the Micro-Coherence Oximetry Network Strength (MCO-S). An associated MCO-S system (100) includes a wearable (102), a user device (112) and a processing platform (123). The wearable (102) collects subject information sufficient to enable monitoring and optimization of the subjects Default Mode Network include sensors such as pulse oximetry instrumentation and EEG electrodes to obtain brainwave data, oxygen saturation data, heart rate variability data, and galvanic skin conductance data. Information from the sensors may be communicated to a user device (112), such as a cell phone or VR headset. The user device (112) communicates with a remote processing platform (123) that may execute artificial intelligence functionality and other logic in connection with assessing the patients micro-coherence network strength and optimizing behavior modification protocols in relation to attributes and objectives of the subject ...

SEQUENTIAL MAPPING OF CARDIAC ARRHYTHMIA WITHOUT FIDUCIAL TIME REFERENCE

A method for generating a propagation and velocity maps for cardiac wavefront propagation including cardiac arryhthmia, sinus rhythm, and paced rhythm. Activation time information is generated in the absence of any time alignment reference, wherein an estimated activation time is a weighted summation of potentially nonlinear and nonorthogonal candidate functions (CFs) selected from a bank of CFs. Time alignments between sequential recordings may be done by including binary level functions among selected CFs. Embodiments are applicable to single cather mapping and sequential mapping, and are robust as confirmed by the ability to generate propagation maps and conduction velocity in the presence of multiple colliding wavefronts. The propagation and conduction velocity maps may be used for one or more of diagnosing cardiac arryhthmia, localizing cardiac arryhthmia, guiding catheter ablation therapy of cardiac arryhthmia, and guiding cardiac pacing therapy.

Method, device and equipment for evaluating credibility of electrocardiogram detection result and storage medium

The invention discloses a method, device and equipment for evaluating the credibility of an electrocardiogram detection result and a storage medium, and the method comprises the steps: inputting an electrocardiogram detection original waveform into a pre-trained waveform feature extraction model, and obtaining extracted waveform features; inputting the waveform features into a pre-trained waveform reconstruction model to obtain a reconstructed waveform; and obtaining the credibility of the electrocardiogram detection result according to the reconstructed waveform and the electrocardiogram detection original waveform. According to the method for evaluating the credibility of the electrocardio detection result provided by the embodiment of the invention, waveform reconstruction can be carried out on the waveform characteristics of electrocardio detection through the pre-trained neural network model, and the credibility of the electrocardio detection result is obtained by analyzing the error ...

Noninvasive blood pressure measurement and monitoring

A Noninvasive Blood Pressure (NIBP) device, method, and system may employ one or more sensors configured to sense physiological changes associated with cardiovascular function and provide signals corresponding to the sensed physiological changes; one or more signal detectors to detect an ECG signal, a PPG signal, and a PCG signal from the signals provided by the one or more sensors; a computational system configured to derive signal features related to the detected signal waveforms; process the signal features to determine measurements of noninvasive blood pressure using one or more independent prediction models; and output a result of the determination.

Method and system for eliminating a broad range of cardiac conditions by analyzing intracardiac signals providing a detailed map and determining potential ablation points

A system and method for improving ablation procedures is presented. The method may comprise measuring EGM signals; performing three dimensional mapping of the EGM signals; and detecting a location for ablation based on the mapping. The method may further comprise creating a potential duration map, a local activation time map, and a bipolar voltage map. The method may further comprise creating a PDM by defining a window of interest (WOI) comprising at least a cycle length; calculating previous heart beats based on the cycle length and reference annotation; and assigning the heart beats within the cycle length of the WOI to the WOI. The method may further comprise detecting a location for ablation by finding start and end potential durations for the WOI; calculating a potential duration value using the start and end potential durations; selecting an ablation point; and using the selected ablation point as the detected location.

WEARABLE AMBULATORY MEDICAL DEVICE WITH MULTIPLE SENSING ELECTRODES

A wearable arrhythmia monitoring and treatment device for improving confidence in determined arrhythmias prior to treatment includes a plurality of sensing electrodes, one or more therapy electrodes, and an electrode signal acquisition circuit having a plurality of inputs. The electrode signal acquisition circuit is configured to sense a respective signal provided by each of a plurality of different pairings of the plurality of sensing electrodes. The wearable arrhythmia monitoring and treatment device includes a monitoring and detection circuit including at least one processor configured to analyze the respective signals provided by each of the plurality of different pairings of the plurality of sensing electrodes, change a confidence level in a determined arrhythmia condition based on the respective signals provided by the plurality of different pairings of the plurality of sensing electrodes, and initiate a therapy to the patient via the one or more therapy electrodes based on the confidence ...

Computer-implemented method of handling electrocardiogram data

This specification describes a method of visually displaying electrocardiogram data in a compressed manner on the display screen wherein rhythmic information is visible and a method of categorizing zones of the electrocardiogram data.

Subcutaneous insertable cardiac monitor optimized for long-term electrocardiographic monitoring

Long-term electrocardiographic and physiological monitoring over a period lasting up to several years in duration can be provided through a continuously-recording subcutaneous insertable cardiac monitor (ICM). The sensing circuitry and the physical layout of the electrodes are specifically optimized to capture electrical signals from the propagation of low amplitude, relatively low frequency content cardiac action potentials, particularly the P-waves that are generated during atrial activation. In general, the ICM is intended to be implanted centrally and positioned axially and slightly to either the left or right of the sternal midline in the parasternal region of the chest. Additionally, the ICM includes an ECG sensing circuit that measures raw cutaneous electrical signals and performs signal processing prior to outputting the processed signals for sampling and storage.

Flow sensor for ventilation

A flow sensor system for ventilation treatment comprises a flow conduit configured to allow gas flow between a first region and a second region, the flow conduit defining a lumen for the gas flow; a flow restrictor disposed within the lumen of the flow conduit between the first region and the second region; a first absolute pressure sensor disposed adjacent to the first region of the flow conduit and configured to measure a pressure of the gas flow at the first region of the flow conduit; and a second absolute pressure sensor disposed adjacent to the second region of the flow conduit and configured to measure pressure of the gas flow at the second region of the flow conduit.

Left ventricular assist device adjustment and evaluation

Systems and methods are described herein for evaluation and adjustment of a left ventricular assist device (LVAD). The systems and methods may utilize at least a plurality of external electrodes to monitor cardiac electrical activity before and during LVAD therapy. The cardiac electrical activity as well as other information such cardiac sound information may be used to determine and adjust one or more LVAD output parameters such as pump speed.

Method and tracking system for tracking a medical object

The disclosure relates to a method and a tracking system for tracking a medical object. Herein, image data obtained by an imaging method and a predetermined target position is acquired for the medical object. The image data is used to detect the medical object automatically by an image processing algorithm and track the position thereof in a time-resolved manner. Furthermore, it is furthermore indicated when, or that, the detected medical object has reached the target position. A plurality of the detected positions of the medical object and associated detection times are stored in a database.

Heart rate variability analysis method, device and use thereof

A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Systems and methods for ablating tissue

Intra-cardiac voltage data display systems display a plurality of data sets derived at least from intra-cardiac voltage data sampled by an electrode. In some embodiments, at least some of the data sets are derived from a portion of the intra-cardiac voltage data that excludes an excludable portion of the intra-cardiac voltage data having a relationship with an occurrence of a particular cardiac event to facilitate identification of the existence of a transmural lesion in tissue adjacent the electrode. In some embodiments, the particular cardiac event is the occurrence of an R wave in the cardiac cycle, and the excludable portion is a V wave in the cardiac cycle.

Способ количественной оценки активности акупунктурных каналов, система и модуль для его осуществления

Группа изобретений относится к медицине, а именно к способу количественной оценки активности акупунктурных каналов (АК) на основе термопунктурного теста Акабане, а также к системе и модулю сбора и обработки данных для его осуществления. При этом у испытуемого методом фотоплетизмографии проводят запись пульсовой волны. Затем синхронно с каждой записью измеряют пороги его температурной болевой чувствительности на диагностических точках акупунктурных каналов в ходе термопунктурного теста Акабане. Формируют из первичной пульсовой волны её вторую акселерационную производную с выделением стандартных волн a, b, c, d, e, f с расчетом их временных и амплитудных характеристик и их соотношений, на основе которых рассчитывают стандартные фазовые показатели пульсовой волны SDNN, DEI, TP, Etc, EEI, DDI, а также спектральные составляющие вариабельности сердечного ритма с расчётом спектров LF, HF, VLF и их соотношений. Создают для конкретного испытуемого из ряда парных выборок показателей пульсовой волны ...

СИСТЕМА И СПОСОБ АВТОМАТИЗИРОВАННОГО АНАЛИЗА И ИНТЕРПРЕТАЦИИ ЭЛЕКТРОКАРДИОГРАММЫ

Группа изобретений относится к медицине. Способ определения характеристик электрокардиограммы (ЭКГ) осуществляют с помощью системы, содержащей средство обработки и устройство регистрации ЭКГ. При этом получают ЭКГ-сигнал с помощью устройства регистрации. Получают с помощью средства обработки сглаженный ЭКГ-сигнал посредством фильтрации шумов полученного ЭКГ-сигнала. Вычисляют с помощью средства обработки первые производные сглаженного ЭКГ-сигнала. Определяют с помощью средства обработки характеристики ЭКГ на основе первых производных сглаженного ЭКГ-сигнала. На основе обработки распределения локальных экстремумов первых производных сглаженного ЭКГ-сигнала определяют порог для выделения диапазона изменения экстремумов, соответствующих разным типам зубцов. Определяют характеристики вершин зубцов разных типов на основе выделенных диапазонов изменения экстремумов и взаимного расположения локальных максимумов и минимумов первых производных сглаженного ЭКГ-сигнала. Обеспечивается автоматическое ...

NEUROSTIMULATION TITRATION UTILIZING T-WAVE ALTERNANS

Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level until a target T-wave alternans change from a baseline T-wave alternans is achieved.

Method and apparatus for synchronizing impedance cardiography with electrocardiography to lower patient auxiliary current

An approach is provided for synchronizing an impedance cardiography (“ICG”) measurement period with an electrocardiography (“ECG”) signal to reduce patient (105) auxiliary current. The approach involves measuring an ECG signal of a patient via an ECG device (103). The approach also involves processing the ECG signal to cause, at least in part, a detection of one or more ECG features of the signal. The approach further involves synchronizing a start, a stop, or a combination thereof of a measurement of an ICG signal of the patient via an ICG device (101) based, at least in part, on the detection of the one or more ECG features. The measurement of the ICG signal includes injecting an electrical current into the patient (105) for a duration of the measurement.

Monitoring health status of people suffering from chronic diseases

Methods and systems for monitoring health status of chronically ill people are provided. An example system includes a wearable device with sensors, with the wearable device being designed to be worn on a wrist of a patient. The wearable device is operable to continuously collect, via sensors, sensor data from a single place on body of the patient. The sensor data are processed to obtain electrocardiogram data and photoplethysmogram data. The electrocardiogram data and the photoplethysmogram data are analyzed to obtain medical parameters associated with a chronic disease. Based at least partially on the changes in the medical parameters over time, a progression of the at least one chronic disease can be determined. Based on the progression, messages regarding the current health condition are sent to the patient. The messages include advice to take medicine or contact a medical professional if a chronic condition is worsening.

MOBILE ECG SENSOR APPARATUS

The embodiments presented herein provide a device comprising a sensor assembly configured to sense physiological signals corresponding to physiological parameters of a user when in contact with the user, and to produce electrical signals representing the sensed physiological signals. The device may also comprise a converter assembly that is electrically connected to the sensor assembly, and is configured to convert the electrical signals to a modulated signal. The device may further comprise a transmitter that transmits the modulated signal wirelessly to a computing device. The device may include a housing that contains the sensor assembly, the converter assembly, and the transmitter.

Interpolation of dynamic three-dimensional maps

A method, including acquiring initial signals from selected positions in a heart, computing respective initial local values of a signal propagation metric at the selected positions, and interpolating the initial local values between the selected positions to compute initial interpolated values of the signal propagation metric at intermediate positions, between the selected positions. The method further includes acquiring subsequent signals from the positions, computing respective subsequent local values of the signal propagation metric at the selected positions, and spatially interpolating the subsequent local values of the signal propagation metric between the selected positions to compute subsequent interpolated values of the signal propagation metric at the intermediate positions. A map of the signal propagation metric is displayed, and when the subsequent interpolated values exceed a bound defined with respect to the initial interpolated values, an indication is provided on the map ...

System and methods for consciousness evaluation in non-communicating subjects

Disclosed is a method for the generation of a consciousness indicator for a non-communicating subject, including the steps of generating an auditory stimulation, receiving an electrocardiographic signal of the subject obtained from a recording during the generation of the auditory stimulation, extracting at least one feature from the electrocardiographic signal and deducing a consciousness indicator from an analysis of the electrocardiographic feature.

DECISION TREE BASED SYSTEMS AND METHODS FOR ESTIMATING THE RISK OF ACUTE CORONARY SYNDROME

The invention provides decision tree based systems and methods for estimating the risk of acute coronary syndrome (ACS) in subjects suspect of having ACS. In particular, systems and methods are provided that employ additive decision tree based algorithms to process a subject's initial cardiac troponin I or T (cTnI or cTnT) concentration, a subject's cTnI or cTnT rate of change, and at least one of the following: the subject's age, the subject's gender, the subject's ECG value, the subject's hematology parameter value, to generate an estimate risk of ACS. Such risk stratification allows, for example, patients to be ruled in or rule out with regard to needing urgent treatment.

SYSTEMS AND METHODS FOR QUANTITATIVE ECG HETEROGENEITY-GUIDED OPTIMIZATION OF THERAPEUTIC EFFICACY OF IMPLANTABLE CARDIAC DEVICES

Disclosed herein are example methods and systems for predicting efficacy of pacemakers or cardiac resynchronization therapy (CRT) devices prior to implantation in patients based on electrocardiogram (ECG) heterogeneity analysis. A method of determining or predicting efficacy of implanting a pacemaker or cardiac resynchronization therapy (CRT) device in a patient includes receiving a first set of electrocardiogram (ECG) signals associated with the patients heart from spatially separated leads, analyzing data from the first set of ECG signals, quantifying a spatio-temporal heterogeneity of the first set of ECG signals based on the analysis, and determining or predicting efficacy of implanting the pacemaker or cardiac re-synchronization therapy (CRT) device in the patient based on the quantified spatio-temporal heterogeneity.

Automatic method to delineate or categorize an electrocardiogram

Disclosed is a method for computerizing delineation and/or multi-label classification of an ECG signal, including: applying a neural network to the ECG, labelling the ECG, and optionally displaying the labels according to time with the ECG signal.

Wearable computing device

A smart ring includes a curved housing having a U-shape interior storing components including: a curved battery approximately conforming to the curved housing, a semi-flexible PCB approximately conforming to the curved housing and having mounted thereon: a motion sensor for generating motion data from physical perturbations of the smart ring, a memory for storing executable instructions, a transceiver for sending data to a client computer, a temperature sensor, and a processor for receiving motion data and performing executable instructions in response thereto, and a potting material disposed in the interior, forming an interior wall of the smart ring, wherein the potting material encapsulates the components and is substantially transparent to visible light, infrared light, and/or ultraviolet light.

SYNCHRONIZING SENSORS USING HEART RATE SIGNALS

It is described a method (100) and system (1) of synchronizing output signals (S1, S2) from a plurality of sensors (11, 12) each measuring a heart rate derivable physiological signal of a subject. The method comprises providing a first output signal (S1) of a first sensor (11) configured to measure a heartbeat derivable physiological signal of a subject; providing a second output signal (S2) of a second sensor (12) configured to measure a heart rate derivable physiological signal of the subject, wherein each of the first and second sensor comprises an independent clock (11a, 12a) for associating the first and second output signals with a respective time domain. The method further comprises the steps of: determining first and second heart rate sequence signal (r1, r2) from the first and second output signals; identifying timings of at least one heart rate event in the respective first and second heart rate sequence signals; and determining a first time domain transformation for the time ...

DETECTING CONDITIONS USING HEART RATE SENSORS

This relates to methods for measuring irregularities in a signal and corresponding devices. The devices can include a PPG sensor unit configured to detect multiple occurrences of a given event in the measured signal(s) over a sampling interval. In some instances, the device can register the occurrences of the events. In some examples, the device can include one or more motion sensors configured to detect whether the device is in a low-motion state. The device may delay initiating measurements when the device is not in a low-motion state to enhance measurement accuracy. Examples of the disclosure further include resetting the sample procedure based on one or more factors such as the number of non-qualifying measurements. In some examples, the device can be configured to perform both primary and secondary measurements, where the primary measurements can include readings using a set of operating conditions different from the secondary measurements.

WAVEFRONT ANALYSIS BASED ON ABLATION PARAMETERS

СПОСОБ ОТОБРАЖЕНИЯ ЭЛЕКТРОКАРДИОГРАФИЧЕСКОГО ВОЛНОВОГО СИГНАЛА И УСТРОЙСТВО ДЛЯ АНАЛИЗА ЭЛЕКТРОКАРДИОГРАММ

Группа изобретений относится к медицине, а именно к способу отображения волнового сигнала электрокардиограммы (ЭКГ) и устройству анализа ЭКГ. При этом выделяют множество сегментов-кандидатов анализа из собранного волнового сигнала ЭКГ с помощью секции выделения. Отображают с помощью секции отображения выделенные сегменты-кандидаты на одном экране таким образом, чтобы части множества сегментов-кандидатов перекрывали друг друга, а другие части множества сегментов-кандидатов не перекрывались. Обеспечивается эффективность аналитических вычислений в непрерывном режиме за счет включения области перекрывания при недостаточности собранных данных волнового сигнала и исключение излишних вычислений за счет использования неперекрывающейся области. 3 н. и 6 з.п. ф-лы, 19 ил.

Способ количественной оценки нарушения реполяризации миокарда при новой коронавирусной инфекции

Изобретение относится к медицине и может быть использовано для количественной оценки нарушения реполяризации миокарда при новой коронавирусной инфекции. При этом у пациентов с новой коронавирусной инфекцией после снятия стандартной 12-канальной электрокардиограммы с помощью электрокардиографа со скоростью 25 mm/s и вольтажом 10 mm/Mv производят цифровую постобработку с помощью математической программы методом соотнесения миллиметровых сеток. После этого производят построение изолинии, обозначение точек J, Т-начало и Т-конец и проведение через них перпендикуляров. Затем осуществляют выборку трех представительских комплексов в каждом отведении с последующим построением неправильной фигуры и автоматическим расчетом ее площади. При этом учитывают полярность при измерении площади для зубцов Р и Т, сегмента ST-T, но не учитывают полярность для комплекса QRS. Производят расчет среднего из трех полученных значений. Для констатации факта изменения реполяризации сравнивают площади зубцов и сегментов ...

СПОСОБ РАННЕЙ ДИАГНОСТИКИ РЕПЕРФУЗИОНННОЙ ИШЕМИИ МИОКАРДА

Изобретение относится к медицине, а именно к кардиологии. Проводят исследование на 12-канальном кардиографе ЭКГ высокочастотных комплексов QRS при поступлении и через 10-12 часов после стентирования коронарных артерий. Анализируют длительность комплекса QRS, увеличение дисперсии корректированного интервала QT, расчетное значение вероятности наличия острой ишемии миокарда в процентах, сумма баллов зон сниженной амплитуды (RAZ), корень квадратный из суммы квадратов амплитуд высокочастотных компонентов QRS комплекса, мкВ, количество отведений ЭКГ, у которых интервал между максимумами огибающей высокочастотного сигнала > 40 мсек. При положительной разнице модулей сумм изменения показателей, влияющих на усилении ишемии, и модулей сумм изменения показателей, влияющих на ослабление ишемии, диагностируют наличие реперфузионной ишемии и аритмогенности миокарда. Способ позволяет повысить точность ранней диагностики реперфузионной ишемии миокарда не позднее 12 часов после выполнения селективной коронарографии ...

Способ дифференциальной диагностики аритмий у подростков, больных туберкулезом органов дыхания

Изобретение относится к медицине, а именно к кардиологии и фтизиатрии, и может быть использовано для дифференциальной диагностики аритмий у подростков, больных туберкулезом органов дыхания. При проведении противотуберкулезной терапии проводят ЭКГ, и при регистрации удлинения интервала QTc>460 мс на фоне тахикардии проводят клинический анализ крови с контролем уровня гемоглобина, сывороточного железа, фолиевой кислоты, калия и натрия. При снижении уровня гемоглобина ниже 115 г/л, сывороточного железа ниже 9,0 мкмоль/л у девочек и ниже 11,6 мкмоль/л у мальчиков и отсутствии отклонений от возрастной нормы в показателях фолиевой кислоты, натрия и калия, диагностируют аритмию, вызванную железодефицитной анемией. При снижении уровня гемоглобина ниже 115 г/л, сывороточного железа ниже 9,0 мкмоль/л у девочек и ниже 11,6 мкмоль/л у мальчиков, фолиевой кислоты ниже 3,1 нг/мл, и отсутствии отклонений от возрастной нормы в показателях натрия и калия, диагностируют аритмию, вызванную железодефицитной ...

Аппаратно-программное устройство для измерения ЭКГ

Полезная модель относится к области медицинской техники, в частности к носимому устройству для получения электрокардиографических (ЭКГ) измерений. Задачей полезной модели является упрощение использования и надежность эксплуатации устройства мониторинга ЭКГ в процессе регистрации и диагностики различных нарушений ритма в домашних и стационарных условиях. Указанная задача решается тем, что аппаратно-программный комплекс для диагностики сложных нарушений ритма, содержащий: электроды, аккумулятор и разъем для подключения внешних электродов, обеспечивающих регистрацию ЭКГ, устройство мониторинга ЭКГ, закрепляемое на пользователе, в котором установлены микроконтроллер, аналого-цифровой преобразователь, блок хранения данных ЭКГ, блок связи, блок хранения данных ЭКГ с внешним вычислительным устройством. Отличие состоит в том, что аппаратно-программный комплекс осуществляет передачу информации из блоков памяти монитора на внешнее вычислительное устройство через дополнительное передающее устройство ...

CONDUCTION SYSTEM PACING WITH ADAPTIVE TIMING TO MAINTAIN AV AND INTER VENTRICULAR SYNCHRONY

An implantable medical device system is configured to generate signals representing activity of a heart of a patient; determine, based on the signals, an intrinsic delay of the heart of the patient; determine whether the intrinsic delay is indicative of a first-degree heart block being present in the heart of the patient; determine a patient-specific timing regime for conduction system pacing based on whether the intrinsic delay is indicative of the first-degree heart block being present in the heart of the patient; and administer cardiac pacing to a native conduction system of the heart of the patient based on the timing regime.

AUTOMATIC DETERMINATION AND SELECTION OF FILTERING IN A CARDIAC RHYTHM MANAGEMENT DEVICE

Methods and/or device facilitating and selecting among multiple modes of filtering a cardiac electrical signal, in which one filtering mode includes additional high pass filtering of low frequency signals, relative to the other filtering mode. The selection filtering modes may include comparing sensed signal amplitude to one or more thresholds, using the multiple modes of filtering. In another example, an additional high pass filter is enabled, over and above a default or baseline filtering mode, and the detected cardiac signal is monitored for indications of possible undersensing, and/or for drops in amplitude toward a threshold, and the additional high pass filter may be disabled upon finding of possible undersensing or drop in signal amplitude.

Expended wear ambulatory electrocardiography and physiological sensor monitor

An extended wear electrocardiography and physiological sensor monitor recorder is provided. A set of electrical contacts extend from a bottom surface of a proximal end of a sealed housing. The sealed housing includes electronic circuitry, including an electrographic front end circuit to sense electrocardiographic signals and a micro-controller interfaced to the electrocardiographic front end circuit to sample the electrocardiographic signals. A patient feedback button located is on a top surface of the proximal end of the sealed housing and positioned above the feedback bottom on the distal end.

Systems and methods of determining location using a medical device

A medical device capable of determining its location is provided. The medical device comprises a memory, one or more antennas, one or more processors coupled with the memory and the one or more antennas, a location manager component executable by the one or more processors. The location manager component is configured to receive first location information from a first location information source and second location information from a second location information source, to rank the first location information source and the second location information source according to a hierarchy of location information sources, the hierarchy of location information sources specifying that the first location information source is of higher rank than the second location information source, determine an approximate location of the medical device based on the first location information, and improve the accuracy of the approximate location based on the second location information.

Identifying an attribute of an electromagnetic source configuration by matching simulated and patient data

Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration. The systems may generate a cardiogram for each source configuration from the modeled electromagnetic output of that source configuration for use in predicting the source ...

Myocardial analysis apparatus and myocardial excitation detection apparatus

A myocardial excitation complementation/visualization apparatus includes an acquiring section that acquires intracardiac electrocardiograms of a subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes, a processing section that performs a computation for completing and visualizing a state of excitation in a myocardium of the subject based on the intracardiac electrocardiograms, and a displaying section that displays the state of excitation in the myocardium of the subject based on an output of the processing section. The processing section includes a first generating section, a correcting section, a second generating section, and a third generating section. The displaying section displays a change of the state of excitation in the myocardium of the subject based on the visualized data.

Machine learning using clinical and simulated data

Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration. The systems may generate a cardiogram for each source configuration from the modeled electromagnetic output of that source configuration for use in predicting the source ...

System and method of assessing intra-arterial fluid volume using intelligent pulse averaging with integrated EKG and PPG sensors

A system using combined electrocardiography (EKG) and photoplethysmography (PPG) sensing to assess intra-arterial fluid volume is described. The system uses averaging of similar pulses based on prior (n−1; n minus 1) R-to-R pulse wave duration, and prior-prior (n−2; n minus 2) R-to-R pulse wave duration, to determine a patient's fluid status and whether it is below or above optimal intravascular hydration.

CARDIAC CONDUCTION SYSTEM EVALUATION

PREMATURE BEAT DETECTION METHOD, AND ELECTRONIC DEVICE THEREFOR AND MEDIUM

This application relates to the field of information processing technologies, and discloses a premature beat detection method, an electronic device, and a medium. The premature beat detection method in this application includes: performing premature beat detection on a user by using a premature beat detection function; determining a premature beat type of the user by using a premature beat type determining function when detecting that the user has a premature beat by using the premature beat detection function, and calculating premature beat load of the user based on detection data obtained by the premature beat detection function; and reminding the user of a premature beat risk when the calculated premature beat load is greater than a premature beat load threshold corresponding to the premature beat type determined by the premature beat type determining function. A premature beat detection technology in this application avoids a disadvantage that a single detection function of an electronic ...

ИТЕРАЦИОННОЕ КОГЕРЕНТНОЕ КАРТИРОВАНИЕ ЭЛЕКТРОФИЗИОЛОГИЧЕСКОЙ АКТИВАЦИИ СЕРДЦА, ВКЛЮЧАЮЩЕЕ В СЕБЯ ВЛИЯНИЕ ПОВТОРНОГО ВХОДА

Группа изобретений относится к медицине, а именно к способу и системе итерационного когерентного картирования электрофизиологической активации сердца. При этом принимают входное сетчатое представление сердечной камеры, набор измеренных местоположений на ткани стенки сердечной камеры и соответствующий набор значений локального времени активации (LAT), измеренных в указанных местоположениях. Перестраивают входную сетку в правильную сетку, содержащую многоугольники правильной формы. Согласовывают данные набора измеренных местоположений и соответствующих LAT с многоугольниками правильной формы. Осуществляют итерационный расчет для многоугольников правильной формы соответствующих значений LAT так, чтобы получать циклическое решение ЭФ–волны активации по правильной сетке, которое учитывает повторный вход ЭФ–волны. Итерационный расчет соответствующих значений LAT содержит итерационное решение набора комплекснозначных уравнений, выполненных с возможностью описания повторного входа ЭФ–волны путем ...

СПОСОБ ОТОБРАЖЕНИЯ ЭЛЕКТРОКАРДИОГРАФИЧЕСКОГО ВОЛНОВОГО СИГНАЛА И УСТРОЙСТВО ДЛЯ АНАЛИЗА ЭЛЕКТРОКАРДИОГРАММ

Группа изобретений относится к медицине, а именно к способу отображения формы волнового сигнала электрокардиограммы (ЭКГ) и устройству для анализа ЭКГ. При этом сохраняют измеренную форму волнового сигнала ЭКГ в секции хранения. Выделяют множество сегментов сигнала из сохраненной формы волнового сигнала, которые отличаются друг от друга во времени. Отображают с помощью секции управления отображением множество сегментов на экране в виде сигналов-кандидатов для анализа. Выполняют с помощью арифметической секции анализ сегмента, выбранного пользователем среди множества сегментов, отображаемых на экране. Отображают с помощью секции управления отображением результат анализа на том же экране, на котором отображается множество сегментов волнового сигнала ЭКГ. Обеспечивается проверка результатов исследования при помощи меньшего числа процедур за счет отображения результатов анализа волнового сигнала ЭКГ одновременно с экраном волнового сигнала объекта анализа, избавляя пользователя от необходимости ...

СПОСОБ ПРОГНОЗА ТИПА ГОРМОНАЛЬНОГО РЕАГИРОВАНИЯ НА СТРЕСС

Изобретение относится к области медицины, а именно к медицинской психологии, и может быть использовано для прогноза типа гормонального реагирования на стресс. Проводят КГ, ЭЭГ, психологическое тестирование. Предъявляют пациенту шесть видеозаписей. По заявленной формуле рассчитывают линейные дискриминантные функции (ЛФД) по 14 показателям. При значении ЛДФ менее 93,626 диагностируют неадаптивный тип гормонального реагирования. При значении ЛДФ более 93,626 - адаптивный тип гормонального реагирования. Способ позволяет с высокой вероятностью оценить тип гормонального стресс-реагирования за счет оценки комплекса наиболее значимых показателей. 4 ил., 3 табл., 2 пр.

MICRO-COHERENCE NETWORK STRENGTH AND DEEP BEHAVIOR MODIFICATION OPTIMIZATION APPLICATION

A subjects Default Mode Network is accessed through corresponding measurements of the Micro-Coherence Oximetry Network Strength (MCO-S). An associated MCO-S system (100) includes a wearable (102), a user device (112) and a processing platform (123). The wearable (102) collects subject information sufficient to enable monitoring and optimization of the subjects Default Mode Network include sensors such as pulse oximetry instrumentation and EEG electrodes to obtain brainwave data, oxygen saturation data, heart rate variability data, and galvanic skin conductance data. Information from the sensors may be communicated to a user device (112), such as a cell phone or VR headset. The user device (112) communicates with a remote processing platform (123) that may execute artificial intelligence functionality and other logic in connection with assessing the patients micro-coherence network strength and optimizing behavior modification protocols in relation to attributes and objectives of the subject ...

Self-adaptive synchronous defibrillator for different abnormal heart rhythms and defibrillation control method

The invention belongs to the technical field of defibrillation, provides a self-adaptive synchronous defibrillator for different abnormal heart rhythms and a defibrillation method, and solves the problem that self-adaptive synchronous defibrillation for different abnormal heart rhythms cannot be realized at present. The system comprises a control module, a charging circuit, an energy storage capacitor, a high-voltage detection circuit, a discharging circuit and a wave detection circuit. The control module controls whether to call the R-wave detection module, the driving circuit, the charging circuit, the high-voltage detection circuit and the discharging circuit or not according to different electrocardiogram classification results. The advantages of software and hardware defibrillation are comprehensively utilized, self-adaptive synchronous defibrillation can be achieved for various different abnormal heart rhythms, and high-efficiency, low-delay and high-quality defibrillation performance ...

HEARTBEAT BASED SELECTION OF IMAGES FOR CARDIOVASCULAR MODEL

To create a 3D model of part of a cardiovascular system, two 2D images taken of different orientations of the cardiovascular system may be combined. The 2D images originate from video streams taken at different points in time, which comprise frames showing a beating heart, and thus a moving cardiovascular system. Because of this movement, not just any random set of two 2D images may result in useable 3D model. To select a proper set of two 2D images, a method is provided wherein said selection is based on cardiac cycle data. The cardiac cycle data may comprise heart activity data as a function of time and timing data on cycle events. These cycle events may be repetitive, as the same events occur with every heartbeat. The selected frames are preferably selected at, or approximately at, similar events. 2. The method according to claim 1 , wherein the cardiac cycle data comprises heart activity data as a function of time.3. The method according to claim 1 , wherein the second cycle event is equivalent to the first cycle event.4. The method according to claim 1 , further comprising:selecting, from the first frames, based on the first cycle event, multiple first selected frames related to the first cycle event;selecting, from the second frames, based on the second cycle event, multiple second selected frames related to the second cycle event;identifying, in at least a first of the first selected frames and the second selected frames, a first image region depicting a cardiovascular structure;comparing, in the first of the first selected frames and the second selected frames, at least one characteristic of the first image region;based on the comparing, selecting from the first of the first selected frames and the second selected frames, a first model frame; andbuilding the 3D model using the first model frame.5. The method according to claim 4 , further comprising:identifying, in a second of the first selected frames and the second selected frames, a second image region ...

NON-INVASIVE PREDICTION OF RISK FOR SUDDEN CARDIAC DEATH

A method and apparatus for the quantitative determination of an individual's risk for sudden cardiac death (SCD) is described. Risk determination is accomplished and may have a sensitivity and specificity of greater than 95%, by generating linear and nonlinear mathematical digital ECG-constructed models from digital ECG-type data of an individual's digital ECG, determining stability/instability of digital ECG-constructed control model systems corresponding to the digital ECG-constructed models by a plurality of techniques and transforming stability/instability values obtained by the determining stability/instability into a quantitative value reflecting an individual's risk for SCD.

System and method for electrophysiological mapping

An electrophysiology map of a portion of a patient's anatomy can be visualized using an electroanatomical mapping system. The system receives a plurality of electrophysiology data points (e.g., an electrophysiology map), which includes a plurality of electrophysiology signals. The system then creates a distribution (e.g., a histogram) for one or more characteristics of the plurality of electrophysiology signals (e.g., dominant cycle length, regular cycle length, peak-to-peak voltage, fractionation, conduction velocity, or the like). The system then analyzes the distribution to determine a display convention (e.g., a range and scale) for a graphical representation of the characteristic based on, for example, a best-fit shape of the distribution, a skew of the distribution, a range of the distribution, and/or a most dominant value of the distribution. The graphical representation can then be output according to the display convention.

EXTENDED WEAR AMBULATORY ELECTROCARDIOGRAPHY MONITOR

An electrocardiography monitor is provided. A sealed housing includes one end wider than an opposite end of the sealed housing. Electronic circuitry is provided within the sealed housing. The electronic circuitry includes an electrographic front end circuit to sense electrocardiographic signals and a micro-controller interfaced to the electrocardiographic front end circuit to sample the electrocardiographic signals. A buzzer within the housing outputs feedback to a wearer of the sealed housing.

Heart failure event rate assessment

This document discusses, among other things, systems and methods to determine an alert state for each of a plurality of patients using received physiologic information, determine an event rate for the plurality of patients for a specific alert state, and adjust a composite HF risk determination for the plurality of patients using the determined event rate.

Patient monitoring and treatment systems and methods

Non-invasive blood pressure (NIBP) systems and methods are disclosed that measure a blood pressure, and in some examples a beat-to-beat blood pressure, of a patient without restricting blood flow. The NIBP systems determine an efficacy of administered cardiopulmonary resuscitation (CPR) to the patient based on the measured blood pressure and are able to optionally output the CPR efficacy or generate user prompts based on the CPR efficacy. Further, the disclosed NIBP systems can generate user instructions to administer further treatment to the patient based on the CPR efficacy.

ECG SYSTEM WITH MULTI MODE ELECTRODE UNITS

Systems and apparatus for monitoring heart muscle activity of an individual include a first electrode unit, for receiving a first signal indicative of electrical, activity at a first location on a body of the individual and a second electrode unit for receiving a second, signal indicative of electrical activity at a second location on the body of the individual. Each of the first and second electrode units is configurable to operate in a field-sensing mode wherein the electrode unit is placed on or it! proximity to the individual's skin, and a current-sensing mode wherein the electrode unit is coupled to a resistive sensor sensing element placed directly on the individual's skin. The field-sensing mode can be either non-contact field-sensing mode.

ELECTROPHYSIOLOGY SYSTEM AND METHOD FOR IDENTIFYING SIGNIFICANT ELECTROGRAMS

At least some embodiments of the present disclosure is directed to a system for processing cardiac information. The system including a processing unit is configured to: receive a plurality of cardiac electrical signals collected from a plurality of electrodes disposed within a cardiac chamber, wherein the plurality of cardiac electrical signals are acquired over a cardiac beat having a cycle length; and calculate an importance metric for each of the plurality of the cardiac electrical signals, wherein the importance metric represents a contribution of a respective cardiac electrical signal to an overall duty cycle of the cardiac beat as a function of the cycle length.

PROSTHETIC AORTIC VALVE PACING SYSTEMS

A valve prosthesis system includes a prosthetic aortic valve (120) and a non-implantable unit. The prosthetic aortic valve (120) includes a plurality of prosthetic leaflets (32); a frame (30); a cathode (54) and an anode (57), which are mechanically coupled to the frame (30); and a prosthetic-valve coil (36), which is in non-wireless electrical communication with the cathode (54) and the anode (57). The prosthetic aortic valve (120) does not include any active electronic components. The non-implantable unit includes an energy-transmission coil; sensing skin ECG electrodes (106); and non-implantable control circuitry, which drives the cathode (54) and the anode (57) to apply a pacing signal to a heart, detect at least one cardiac parameter using the sensing skin ECG electrodes (106), and, at least partially responsively to the detected cardiac parameter, to set parameters of the pacing signal, by wirelessly transferring energy from the energy-transmission coil to the prosthetic-valve coil ...

DIFFERENTIATION OF HEART FAILURE RISK SCORES FOR HEART FAILURE MONITORING

A method for differentiating heart failure risk scores that includes receiving a current data transmission and acquiring patient metrics from a remote device, determining a daily heart failure risk score for each day occurring during a time period from a previous received data transmission to the current received data transmission based on the acquired patient metrics, determining a maximum daily heart failure risk score of the determined daily heart failure risk scores during a lookback window prior to the current received data transmission, determining a heart failure risk status alert for the received data transmission based on the temporal proximity of the determined maximum heart failure risk score and receipt of the current data transmission, selecting a type of notification based on the heart failure risk status differentiation, and indicating the transmission heart failure risk status and the heart failure risk status differentiation via the selected type of notification. 1. A method of differentiating heart failure risk statuses comprising , by processing circuitry:receiving a current data transmission from a remote device;acquiring patient metrics from the current data transmission;determining a heart failure risk status for each data transmission occurring during a time period from a previous data transmission to the current data transmission based on the acquired patient metrics for that data transmission, wherein determining each heart failure risk status comprises selecting one of a predetermined set of heart failure statuses;determining a maximum heart failure risk status of the determined heart failure risk statuses during a lookback window prior to receipt of the current data transmission;determining a transmission heart failure risk status for the current data transmission based on the determined maximum heart failure risk status; anddetermining a heart failure risk status differentiation for the current data transmission based on a temporal ...

Sensing zone for spatially relevant electrical information

Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

System and Method of Measuring Venous Oxygen Saturation Using Intelligent Pulse Averaging With Integrated EKG and PPG Sensors

A system using combined electrocardiography (EKG) and photoplethysmography (PPG) sensing, to determine venous oxygen saturation is described. The system uses averaging of similar pulses based on Prior (or n−1) R-to-R pulse wave duration, and current (or n) R-to-R pulse wave duration for evaluation of the metabolic reserve and/or stress of the patient.

HEART ACTIVITY MONITORING DURING PHYSICAL EXERCISE

A method, apparatus, and computer program monitor a user's heart activity during a physical exercise. A heart activity measurement signal representing the user's heart activity is acquired and a phase component of the heart activity measurement signal is monitored. On the basis of the monitoring of the phase component, one or more actions are carried out.

METHODS AND SYSTEMS FOR DETECTING PACE PULSES

This disclosure relates to methods and systems for detecting pace pulses in electrocardiogram (ECG) data. First ECG data associated with a first sampling frequency can be obtained. Candidate pace pulses in the first ECG data can be identified. Additional data comprising waveform descriptors characterizing the candidate pace pulses can be generated. Second ECG data can be generated by down-sampling the first ECG data. The second ECG data can be associated with a second sampling frequency that is lower than the first sampling frequency. Multiple ECG waveforms can be presented based on the second ECG data. The waveform descriptors characterizing candidate pace pulses can be presented based on the additional data.

Cardiac activation time detection

Method and system for measuring and displaying biosignal data to a wearer of a wearable article

An electrocardiogram (ECG) output A is corrected for anomalous heartbeats 1 by obtaining a series of heart rate values, determining when the rate of change of the heart rate values exceeds a threshold, and identifying a selected heartbeat as anomalous if the threshold is exceeded. The threshold is selected based on a likely signal-to-noise ratio of the ECG output, for example based on obtained activity level information of a user. One or more correcting steps X, X’’ are sequentially applied to the region around the anomalous heart beat. The correcting steps may include one or more of removing, inserting or moving the position of a selected heartbeat. The rate of change of heartrate values may be determined for each correcting step, and the correcting step corresponding to the lowest rate of change is selected as a permanent correction for that region of the ECG output. An embodiment includes a wearable article with a sensor arrangement to obtain the ECG signal.

Method and system for measuring and displaying biosignal data to a wearer of a wearable article

ENHANCED COMPUTATIONAL HEART SIMULATIONS

Methods to enhance the computational localization of cardiac arrhythmia sources are provided. A method may include receiving, from a first user, clinical data associated with a clinical case. The clinical data may include a patient anatomic information, diagnostic and/or treatment modalities, treatment parameters, treatment outcome, and medical literature. The clinical case may be indexed based on a first plurality of characteristics associated with the clinical data. The indexing may include associating at least a portion of the clinical data with a computational simulation of cardiac arrhythmia having a second plurality of characteristics matching the first plurality of characteristics. At least a portion of the clinical data associated with the indexed case may be provided to a second user in response to a query from the user. Related systems and articles of manufacture are also provided.

METHOD FOR STRESS DETECTION UTILIZING ANALYSIS OF CARDIAC RHYTHMS AND MORPHOLOGIES

A method for detecting stress in organisms with a cardiac organ provides a cardiac waveform input to an analysis system, which decomposes the incoming signal to detect patterns within the decomposed segments. The patterns include: the overall waveform of a series of beats, a single beat or segments contained within a beat. The decomposed parts of the cardiac waveform are classified according to types of stress patterns both known in the art and dynamically learned through feedback. When the system detects a sufficient threshold of stress has been exceeded, a notification is generated and details of the stress, such as severity and type, are communicated to an external module, system, user, or host. Patterns indicating a future or rapidly increasing stress level, signaled by evolving patterns in the cardiac waveform, are detected and an alert generated before a major or difficult to control stressful event is externalized by the organism.

Devices and method for determining and monitoring a cardiac status of a patient by using PLVDT or PLVST parameters

The present invention relates to an improved medical device and method for accurately and reliably determining a cardiac status of a patient. An implantable medical device, IMD, comprises a sensor arrangement adapted to sense signals related to mechanical activity of the heart and an activity level sensor arrangement adapted to sense an activity level of the patient. Further, the IMD calculates a percentage of left ventricular diastolic time (PLVDT) for a cardiac cycle corresponding to a relation between a diastolic time interval and a cardiac cycle time interval using the determined systolic and diastolic time intervals or a percentage of left ventricular systolic time (PLVST) for a cardiac cycle corresponding to a relation between a systolic interval time interval and a cardiac cycle time interval. A cardiac status is determined based on the calculated PLVDT (or PLVST) and on an activity level of the patient.

MACHINE LEARNING BASED DEPOLARIZATION IDENTIFICATION AND ARRHYTHMIA LOCALIZATION VISUALIZATION

Techniques that include applying machine learning models to episode data, including a cardiac electrogram, stored by a medical device are disclosed. In some examples, based on the application of one or more machine learning models to the episode data, processing circuitry derives, for each of a plurality of arrhythmia type classifications, class activation data indicating varying likelihoods of the classification over a period of time associated with the episode. The processing circuitry may display a graph of the varying likelihoods of the arrhythmia type classifications over the period of time. In some examples, processing circuitry may use arrhythmia type likelihoods and depolarization likelihoods to identify depolarizations, e.g., QRS complexes, during the episode.

Electroanatomical map re-annotation

A method, including receiving from mapping electrodes positioned at locations within a heart, signals indicating electrical activity in tissue contacting the electrodes, and processing the signals to identify, for each location, at least one corresponding LAT in a cycle of a heart. For each location, an earliest LAT in the cycle is identified, and an electroanatomical map including mapping points having respective locations and showing the earliest LAT at each location is generated and rendered. An input selecting a subset of the points is received, and a time range containing the earliest LAT of a majority of the points in the subset is identified. One or more outlying points in the subset are identified, and a second LAT, later than the earliest LAT in the cycle is found among the at least one identified LAT identified at the outlying points. The map is updated to display the found second LAT.

Apparatus and method for measuring bioinformation

An apparatus and a method of measuring bioinformation are provided. The apparatus for measuring bioinformation includes a first sensor configured to measure a first biosignal including arterial pulse wave information, a second sensor configured to measure a second biosignal including venous or capillary pulse wave information, and a bioinformation estimator configured to estimate bioinformation of a user based on a time delay between the first biosignal and the second biosignal.

Modeling method for screening surgical patients

A modeling method for screening surgical patients, used in analysis modeling for heart rate variability (HRV). Low-cost, portable and wearable signal acquisition equipment is utilized to acquire an electrocardiography (ECG) signal of an epileptic 24 hours before surgery; a multiscale entropy (MSE) of the ECG is calculated by means of a programmed HRV analysis method, wherein characteristic parameters representing heart rate complexity are extracted on the basis of an MSE curve, and a medical refractory epileptic suitable for vagus nerve stimulation (VNS) surgery is accurately and efficiently screened, thus avoiding unnecessary expenditures and avoiding delaying an optimal opportunity for treatment. Meanwhile, the curative effects of the VNS treatment may be wholly improved by means of clearly selecting VNS surgical indication patients according to the characteristic parameters of the MSE complexity of the ECG.

WEARABLE COMPUTING DEVICE

A smart ring includes a curved housing having a U-shape interior storing components including: a curved battery approximately conforming to the curved housing, a semi-flexible PCB approximately conforming to the curved housing and having mounted theron: a motion sensor for generating motion data from physical perturbations of the smart ring, a memory for storing executable instructions, a transceiver for sending data to a client computer, a temperature sensor, and a processor for receiving motion data and performing executable instructions in response thereto, and a potting material disposed in the interior, forming an interior wall of the smart ring, wherein the potting material encapsulates the components and is substantially transparent to visible light, infrared light, and/or ultraviolet light.

Systems and methods of analyte measurement analysis

Disclosed systems include an electrocardiogram sensor and a processing device operatively coupled to the electrocardiogram sensor. The processing device receives electrocardiogram data from the electrocardiogram sensor and applies a machine learning model to the received electrocardiogram data. The machine learning model has been trained based on previous electrocardiogram data of a plurality of subjects. The electrocardiogram data of the plurality of subjects have one or more associated analyte measurements. The processing device may determine an indication of a level of the analyte based on the electrocardiogram data.

MEDICAL PACKAGING WITH INTEGRATED ELECTROCARDIOGRAM SENSOR

Disclosed is an ECG sensor having a packaging label form factor. The ECG sensor may comprise a set of electrodes configured to sense heart-related electrical activity when in contact with skin of a user and produce electrocardiogram (ECG) waveforms representing the sensed heart-related electrical activity. The ECG sensor may further comprise a processor configured to: identify, using a machine learning model, the user based on the ECG waveforms, convert the ECG waveforms to a modulated signal that carries the ECG waveforms representing the sensed heart-related electrical activity, and transmit the modulated signal wirelessly to a computing device using a transmitter. The ECG sensor may also comprise a housing having a first layer and a second layer, wherein the set of electrodes, the processor, and the transmitter are all disposed between the first layer and the second layer of the housing, and wherein the housing has a packaging-label form factor.

SYSTEM OF DETERMINING A RISK SCORE FOR TRIAGE

A METHOD AND APPARATUS FOR DETERMINING RESPIRATORY INFORMATION FOR A SUBJECT

Advanced cardiac waveform analytics

This disclosure describes systems and methods for electrocardiographic waveform analysis, data presentation and actionable advisory generation. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis can be performed on the electrocardiographic waveform data to provide cardiac analytics. A visualization of the cardiac analytics on a dashboard display can be generated. A value can be based on a comparison of the cardiac analytics to at least one baseline value for the patient; and a decision of whether or not to generate an actionable advisory for the electrocardiographic waveform data can be made based on the value. When the actionable advisory is generated, the actionable advisory is sent to one or more medical professionals, where it can be modified, and displayed with the visualization of the cardiac analytics.

Ischemia detection using a heart sound sensor

A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

Высокоточный многоканальный кардиоайгеноскоп

Полезная модель «Высокоточный многоканальный кардиоайгеноскоп» (ВМК) предназначена для анализа некоррелированных компонент электрокардиограмм (ЭКГ), относится к медицинским приборам, применяемым в кардиологии.Конструкция ВМК включает в свой состав блок хранения и выборки 1; высокоточный одноканальный кардиоайгеноскоп с внутренней синхронизацией 2; высокоточный одноканальный кардиоайгеноскоп с внешней синхронизацией 3, а также блок визуализации и управления 4.Объединение в предложенной конструкции двух высокоточных кардиоайгеноскопов - с внутренней синхронизацией (в качестве ведущего) и внешней синхронизацией (в качестве ведомого) - позволяет использовать сигнал синхронизации ведущего кардиоайгеноскопа для управления ведомым кардиоайгеноскопом, что обеспечивает не только повышение точности, но и уменьшает трудоемкость анализа.Высокоточный многоканальный кардиоайгеноскоп может быть реализован в виде программно-аппаратного комплекса или в виде виртуального прибора, дополняющего обычный кардиограф и имеющего с ним связь через его стандартные интерфейсы. 4 з.п. ф-лы, 11 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 185 708 U1 (51) МПК A61B 5/0452 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61B 5/0452 (2018.08); A61B 5/02 (2018.08) (21)(22) Заявка: 2018120085, 31.05.2018 (24) Дата начала отсчета срока действия патента: 14.12.2018 Приоритет(ы): (22) Дата подачи заявки: 31.05.2018 (45) Опубликовано: 14.12.2018 Бюл. № 35 1 8 5 7 0 8 R U (56) Список документов, цитированных в отчете о поиске: RU 128470 U1, 27.05.2013. RU 178010 U1, 19.03.2018. RU 177224 U1, 13.02.2018. RU 177963 U1, 16.03.2018. US 2016022164 A1, 28.01.2016. WO 2010053661 A1, 14.05.2010. US 5092341 A1, 03.03.1992. (54) Высокоточный многоканальный кардиоайгеноскоп (57) Реферат: Полезная модель «Высокоточный внутренней синхронизацией (в качестве ведущего) многоканальный кардиоайгеноскоп» (ВМК) и внешней синхронизацией (в качестве ведомого) ...

Implantable systems and methods for monitoring myocardial electrical stability by detecting pvc induced t-wave alternans reversals

Embodiments of the present invention relate to implantable systems, and methods for use therewith, for assessing a patients' myocardial electrical stability. Implanted electrodes are used to obtain an electrogram (EGM) signal, which is used to identify periods when the patient experiences T-wave alternans. Additionally, the EGM signal is used to determine whether premature ventricular contractions (PVCs) cause phase reversals of the T-wave alternans. The patient's myocardial electrical stability is assessed based on whether, and in a specific embodiment the extent to which, PVCs cause phase reversals of the T-wave alternans. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

Acute ischemia detection based on parameter value range analysis

A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine a normal range of ST deviation for a particular heart rate range. The monitor computes heart rate dependent ischemia detection thresholds based on the upper and lower boundaries of the normal range.

Method and system for identifying cardiac arrhythmia driver sites

A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.

System for Ventricular Function Abnormality Detection and Characterization

A system for heart performance characterization and abnormality detection includes an interface for receiving signal data representing an electrical signal indicating electrical activity of a patient heart over multiple heart beat cycles. A filter extracts first signal component data in a first selected bandwidth and first heart cycle portion of the received signal data and second signal component data in a different second selected bandwidth and second heart cycle portion of the received signal data. A signal processor uses the received signal data in calculating a ratio of a first value derived from the first signal component data to a second value derived from the second signal component data. A patient monitor in response to the calculated ratio or value derived from the calculated ratio, generates an alert message associated with the threshold.

Method and device for early detection of heart attack

A device and method for heart performance characterization and abnormality detection is disclosed herein. The device and method analyze and characterize cardiac electrophysiological signals which help in the diagnosis of myocardial ischemia in advance of a heart attack.

Methods and Devices for Accurately Classifying Cardiac Activity

Methods, systems, and devices for signal analysis in an implanted cardiac monitoring and treatment device such as an implantable cardioverter defibrillator. In illustrative examples, captured data including detected events is analyzed to identify likely overdetection of cardiac events. In some illustrative examples, when overdetection is identified, data may be modified to correct for overdetection, to reduce the impact of overdetection, or to ignore overdetected data. New methods for organizing the use of morphology and rate analysis in an overall architecture for rhythm classification and cardiac signal analysis are also discussed.

Apparatus and method for outputting heart sounds

An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

Implantable systems and methods for use therewith for monitoring and modifying arterial blood pressure without requiring an intravascular pressure transducer

Embodiments of the present invention are directed to implantable systems, and methods for use therewith, that monitor and modify a patient's arterial blood pressure without requiring an intravascular pressure transducer. In accordance with an embodiment, for each of a plurality of periods of time, there is a determination one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes for the left ventricle to generate a pressure pulsation that travels from the patient's aorta to a location remote from the patient's aorta. Based on the one or more metrics indicative of PAT, the patient's arterial blood pressure is estimated. Changes in the arterial blood pressure are monitored over time. Additionally, the patient's arterial blood pressure can be modified by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient's arterial blood pressure and/or monitored changes therein.

Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification

Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.

Data conversion in ecg techniques

A computer-implementable method includes generating a first set of input signals representing an X-lead ECG apparatus, generating a second set of input signals based on the first set and representing a Y-lead ECG apparatus, and generating to a display device a set of ECG traces and/or a diagnosis of acute myocardial infarction based on the second set. X and Y are integer values and Y is greater than X.

System and method for real-time measurement of sleep quality

An embodiment of the invention is directed to a method for the real time monitoring and measurement of sleep quality of a subject comprising the steps of; obtaining information from the subject using sensory signals; analyzing the information contained within the signals using signal processing and artificial intelligence; and using the analyzed information to create a protocol to improve the sleep quality of the subject. Another embodiment of the invention is directed to a system for real time monitoring and measurement of sleep quality of a subject comprising: a means for obtaining sensory information from the subject; a means for transmitting the sensory information; a means for analyzing the sensory information; and a means for creating a protocol to improve the sleep quality of the subject.

Implantable systems and methods for monitoring bnp levels, hf and mi

Methods for monitoring a patient's level of B-type natriuretic peptide (BNP), and implantable cardiac systems capable of performing such methods, are provided. A ventricle is paced for a period of time to provoke a ventricular evoked response, and a ventricular intracardiac electrogram (IEGM) indicative of the ventricular evoked response is obtained. Based on the ventricular IEGM, there is a determination of at least one ventricular evoked response metric (e.g., ventricular evoked response peak-to-peak amplitude, ventricular evoked response area and/or ventricular evoked response maximum slope), and the patient's level of BNP is monitored based on determined ventricular evoked response metric(s). Based on the monitored level's of BNP, the patients heart failure (HF) condition and/or risks and/or occurrences of certain events (e.g., an acute HF exacerbation and/or an acute myocardial infarction) can be monitored.

Method and apparatus to manage lead-related conditions for fault tolerance enhancements

The disclosure describes systems, methods, and apparatus providing detection mechanism for lead-related conditions, including transient behaviors, on a conductive pathway of a medical electrical lead. In one example, a sense path arbitration module identifies a lead-related condition associated with a conductive pathway based on signal processing to identify transients emerging from a propagated signal. The sense path arbitration module may evaluate a plurality of conductive pathways of the medical electrical lead and arbitrates propagation of a sensed signal that is transmitted through the plurality of lead conductors based on the evaluation. Therapy delivery functions utilizing the medical electrical lead may also be controlled in response to the signal processing and identification of the lead-related condition on a conductive pathway.

Method and user interface device for displaying electrocardiograms

A method of displaying electrocardiograms comprises displaying a reference electrocardiogram; and displaying a measured electrocardiogram so that the reference electrocardiogram and the measured electrocardiogram are displayed in an overlapping state.

Detection of drastic blood pressure changes

A cardiac-activity based prediction of a rapid drop in a patient's blood pressure during extracorporeal blood treatment is disclosed. A proposed alarm apparatus includes a primary beat morphology analysis unit bank of secondary analysis units and an alarm generating unit. The primary beat morphology analysis unit discriminates heart beats in a received basic electrocardiogram signal, classifies each beat into one out of at least two different beat categories, and associates each segment of the signal with relevant event-type data. The event-type data and the basic electrocardiogram signal together form an enhanced electrocardiogram signal, based upon which the primary beat morphology analysis unit determines whether one or more secondary signal analyses should be performed. Depending on the enhanced electrocardiogram signal's properties, the bank of secondary analysis units performs none, one or more of up to at least two different types of secondary analyses, and for each analysis performed produces a respective test signal. The alarm generating unit receives the test signals, and triggers an alarm signal indicative of an estimated rapid blood pressure decrease, if at least one alarm criterion is fulfilled.

Sensing zone for spatially relevant electrical information

Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Heart monitoring apparatus

An electrocardiographic device for sensing cardiac activity in a user, the electrocardiographic device comprising: plurality of electrodes provided at a surface of the device for electrical engagement with a pair of extremities of a user; one or more movement sensors arranged to, in use, detect movement of a user's extremities; and a control unit configured to receive electrical signals from the electrodes and to, in use, process said signals in dependence on the output of the one or more movement sensors so as to filter variations from the signals due to movement of the user's extremities.

Systems and methods for st segment stability discrimination during cardiac ischemia detection for use with implantable medical devices

Techniques are provided for discriminating episodes of cardiac ischemia indicated based on shifts in ST segment elevation from false detections due to atrial fibrillation (AF) or other confounding factors such as premature ventricular contractions (PVCs.) In an example for use with a single-chamber device, in response to a possible ischemic event, the single-chamber device assesses ventricular stability based an examination of ventricular intracardiac electrogram (IEGM) signals. If the ventricular IEGM is unstable due to paroxysmal AF or frequent PVCs, the ischemic event is rejected as a false detection. Otherwise, the device responds to the event by, for example, generating warning signals, recording diagnostic data or controlling device therapy. The stability discrimination techniques are particularly advantageous for use within single-chamber devices that lack automatic mode switching but are also beneficial within at least some dual-chamber devices or multi-chamber systems.

Method and system for detection of respiratory variation in plethysmographic oximetry

A method and system for detection of pulsus paradoxus are provided. In one embodiment, the method includes determining a power spectrum density for a plethysmographic waveform and identifying pulsus paradoxus based on the power spectrum density. The power spectrum density may include a first wave peak indicative of a respiratory rate and a second wave peak indicative of a heart rate. Pulsus paradoxus can be identified by comparing a height of the first wave peak and a height of the second wave peak.

Implantable cardiac systems with baseline correction in response to noise detection

Implantable cardiac devices and methods of their use. A method of operation in an implantable cardiac device may include steps for characterizing detected events as noise or not noise, identifying a set of consecutive noise events or a threshold quantity of noise events in a set period of time and declaring a noisy series to have occurred. In response to the declaration of a noisy series, the method initiates a baseline correction algorithm. Devices for performing such methods are also disclosed.

Systems and methods for graphic display of st-segment deviation

Systems and methods are provided for monitoring a patient and graphically representing ST-segment deviations.

Method of Locating the Tip of a Central Venous Catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Apparatus and method for outputting heart sounds

An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

System and Method For Imaging of the Vascular Components with Temporal Information and Suppressed Blood Pools Using Magnetic Resonance Imaging

A system and method is provided that includes a) monitoring a cardiac cycle of the subject to identify a predetermined point and, b) upon identifying the predetermined point, performing the steps of i) performing at least one of a desired number of magnetization suppressing preparations to suppress signal from blood flow through at least the region of interest, ii) acquiring a first set of imaging data from the region of interest, and iii) repeating step i) and step ii) to acquire at least a second set of imaging data from the region of interest. The method further includes c) repeating step b) a predetermined number of times over a series of cardiac cycles to acquire respective sets of medical imaging data of the region of interest and d) reconstructing first set of imaging data and the second set of imaging data into a time-resolved series of images.

Electrocardiographic waveform display method and electrocardiogram analysis device

Electrocardiographic waveforms for a plurality of candidate segments (analysis unit segments) are extracted from collected electrocardiographic waveforms and the extracted electrocardiographic waveforms for the plurality of candidate segments (analysis unit segments) are displayed on one screen. As a result, a user can determine, e.g., what candidate segment (analysis unit segment) analysis results to view while simultaneously viewing the electrocardiographic waveforms for the plurality of candidate segments (analysis unit segments) and which candidate segment to record, without any switching between screens, and as a result can perform appropriate electrocardiogram analysis using a simple operation.

Signal analysis related to treatment sites

A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment.

Method and device to monitor patients with kidney disease

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

IDENTIFICATION AN DPRESENTATION OF DEVICE-TOVESSEL RELATIVE MOTION

Apparatus and methods are described for use with a tool that is inserted into a portion of a body of a subject that undergoes cyclic motion. The apparatus and methods include using an imaging device, acquiring a plurality of images of the tool inside the portion of the body, at respective phases of the cyclic motion. Using at least one computer processor, an extent of movement of the tool with respect to the portion of the body that is due to the cyclic motion of the portion of the body is determined. In response thereto, an output is generated that is indicative of the determined extent of the movement of the tool with respect to the portion of the body. Other applications are also described. 1. An apparatus , comprising: receive an extraluminal image of a body lumen obtained by the extraluminal imaging device;', 'identify, within the extraluminal image, an endoluminal medical device positioned inside the body lumen;', 'automatically calculate a dimension based on identifying the endoluminal medical device within the extraluminal image, wherein the dimension comprises at least one of a value of the endoluminal medical device or a value of the body lumen associated with deployment of the endoluminal medical device; and', the extraluminal image; and', 'the dimension., 'output, a display in communication with the computer processor, a screen display comprising], 'a computer processor configured for communication with an extraluminal imaging device, wherein the computer processor is configured to2. The apparatus of claim 1 , wherein the computer processor is configured to automatically calculate the dimension based on a known dimension of a tool positioned inside the body lumen.3. The apparatus of claim 1 , wherein the tool comprises a guiding catheter claim 1 , and wherein the known dimension comprises a diameter of the guiding catheter.4. The apparatus of claim 1 , wherein the computer processor is configured to automatically calculate the dimension in response to ...

Method and processing device for assessing volume responsiveness

The present invention belongs to the field of medicine and discloses a method for assessing volume responsiveness and a processing device for assessing volume responsiveness. The method comprises: acquiring, by using one or more vibration sensitive sensors, a first parameter associated with a change in preload in a first time interval before a subject performs a passive straight-leg lift in a passive leg raising (PLR) test; acquiring, by using the one or more vibration sensitive sensors, a second parameter associated with a change in preload in a second time interval after the subject performs a passive straight-leg lift in the PLR test; and determining the volume responsiveness of the subject according to the first parameter associated with a change in preload and the second parameter associated with a change in preload. The method provides a convenient and easy determination of volume responsiveness.

Physician's programmer with st-segment histogram display capability

A physician's programmer for an implantable device is disclosed. The programmer includes a receiver for receiving wireless transmission data from the implantable heart monitor. A processor is configured to extract from the wireless transmission data ST-deviation histogram data as a function of heart rate. The histogram data for a particular heart rate range is shown on a display in the form of a bar chart. The histogram data for a plurality of heart rate ranges is shown in the form of a chart with multiple line plots.

System and Method for Distinguishing a Cardiac Event From Noise in an Electrocardiogram (ECG) Signal

A system includes an ambulatory medical device and a server. The ambulatory medical device comprises: a digital signal processing module configured to: detect an abnormal rhythm from an electrocardiogram (ECG) signal of a patient using a first signal processing routine; and generate a first flag indicating an abnormal rhythm is detected; and a noise detector module configured to: receive the ECG signal from the digital signal processing module; execute a second signal processing routine to classify the abnormal rhythm as one of an arrhythmia event and a noise event; and, if the abnormal rhythm is classified as a noise event, initiate a preconfirmation period during which the noise detector module continues to evaluate the abnormal rhythm and classify the abnormal rhythm as one of an arrhythmia event and a noise event using the second signal processing routine; and generate a second flag indicating the start of the preconfirmation period; and a server configured to: receive the ECG signal, the first flag indicating the abnormal rhythm, and the second flag indicating the start of the preconfirmation period; and provide a visual indication of the preconfirmation period.

Physiological information waveform processing method, program, computer readable storage medium, and physiological information waveform processing apparatus

A method is implemented by a computer, and includes: (a) acquiring at least one set of waveform data having a time duration from physiological information waveform data; (b) classifying a waveform included in the waveform data into a predetermined type of waveform; (c) determining validity of a classification result of the waveform; and (d) correcting the classification result in accordance with the validity of the classification result.

Blood pressure estimation apparatus, blood pressure estimation method, and non-transitory computer-readable recording medium

A blood pressure estimation apparatus includes: a pulse wave measurement unit measuring a user's pulse wave signal; an electrocardiogram signal measurement unit measuring a user's electrocardiogram signal; and a processing circuit estimating a user's blood pressure value by using the pulse wave and electrocardiogram signals, wherein the processing circuit (a) acquires a pulse wave signal feature by using the pulse wave signal, (b) acquires an electrocardiogram signal feature by using the electrocardiogram signal, (c) acquires a pulse wave propagation time by using the pulse wave and electrocardiogram signals, (d) selects a blood pressure group indicating a relationship between a pulse wave propagation time and blood pressure of the user by using the pulse wave signal feature, electrocardiogram signal feature, and pulse wave propagation time, and (e) estimates the blood pressure value by using the blood pressure group, pulse wave signal feature, electrocardiogram signal feature, and pulse wave propagation time.

Method and system for ecg based cardiac ischemia detection

An acute ischemia detection device comprises a 12-lead electrocardiograph (ECG) device ( 12 ), an electronic data processing device ( 12 ), and a display component ( 22 ). The electronic data processing device applies 12-lead ECG to vessel-specific lead (VSL) transforms ( 50 ) to 12-lead ECG data acquired by the 12-lead ECG device to generate VSL lead data (e.g., LAD, LCX, and RCA vessel-specific lead data), determines ST values for the VSL lead data, and decides whether the 12-lead ECG data acquired by the 12-lead ECG device indicates acute ischemia by comparing the ST values for the VSL lead data with VSL lead ST thresholds ( 60 ). The display component may display an acute ischemia alarm or warning if the decision is the 12-lead ECG data acquired by the 12-lead ECG device indicates acute ischemia, and/or may display the generated

Fetal Cardiotocography Monitoring

An improved fetal ST monitoring system and method is provided using an ECG monitoring system collecting a plurality of T/QRS segments of a fetus, and a data analysis computer system connected to the ECG monitoring system calculating from the plurality of T/QRS segments.

Posture dependent time series filtering system and methods for the detection of cardiac events

A device for detecting a cardiac event is disclosed. Detection of an event is based on a test applied to a parameter whose value varies according to heart rate. Both the parameter value and heart rate (RR interval) values are filtered with an exponential average filter. The filtered parameter value and heart rate values are stored as separate datasets corresponding to particular body postures. Upper and lower boundary values and detection thresholds of the parameter are computed for each of the datasets. The test to detect the cardiac event depends on the heart rate and the difference between the parameter's value and a corresponding detection threshold.

Cardiovascular Detection System and Method

The detection and diagnosis of a variety of cardiovascular disorders and levels of heart condition, using a novel method and system, according to a comprehensive analysis of cardiac electrical signal via the frequency domain, time domain, spatial domain.

SENSING ZONE FOR SPATIALLY RELEVANT ELECTRICAL INFORMATION

Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest. 1. A method comprising:accessing, by a computing device comprising a processor, data representing electrical activity measured by a set of electrodes arranged on an outer surface of a patient's body within a sensing zone on the outer surface of the patient's body, the sensing zone on the outer surface of the patient's body including a portion of the outer surface of the patient's body having a spatial distribution of electrodes at respective locations that have been previously spatially correlated with and configured to provide electrical information that is representative of electrical activity for a predetermined region of interest of the patient's heart that is less than the entire heart; anddetermining, by the computing device, an estimate of electrical activity for the predetermined region of interest of the patient's heart based on the electrical activity measured by the set of electrodes arranged on the outer surface of the patient's body within the sensing zone.2. The method of claim 1 , further comprising placing the set of electrodes at the respective locations on the outer surface of the patient's body to define the sensing zone.3. The method of claim 2 , wherein placing the set of electrodes comprises arranging the set of electrodes on the outer surface of the patient's body within two or more sensing zones spaced apart and distributed across the outer surface of the patient's body claim 2 , wherein the estimate of electrical activity for the predetermined region of interest is ...

Adaptive event storage in implantable device

Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.

METHOD AND SYSTEM FOR LOGGING QUANTITATIVE SEIZURE INFORMATION AND ASSESSING EFFICACY OF THERAPY USING CARDIAC SIGNALS

A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or brain state change. 1. A method of detecting and logging a non-induced seizure event , comprising:receiving a cardiac signal of a patient into a processor;determining via the processor a first cardiac parameter based on the received cardiac signal;detecting a non-induced seizure based on the first cardiac parameter;determining via the processor at least one seizure characteristic, wherein the seizure characteristic is different from the first cardiac parameter; andlogging the at least one seizure characteristic in a memory.2. The method of claim 1 , wherein the first cardiac parameter is a parameter indicative of at least one of: a change in heart rate; a change in heart rate variability; or a change in an acoustic property of at least one heart beat.3. The method of claim 1 , wherein the at least one seizure characteristic comprises at least one of:a date and a time of an occurrence of the seizure;a start time of the seizure;an end time of the seizure;a duration of the seizure;an intensity of the seizure;a severity of the seizure;a degree of spread of the seizure in a brain of the patient; ora fraction of time spent in the seizure over a moving time window.4. The method of claim 1 , further comprising:logging at least a time of an occurrence for at least two seizure events; anddetermining, based on the logging of the at least two seizure events, a seizure frequency.5. The method of claim 1 , further comprising:receiving an electrocardiogram (“EKG”) signal;receiving a phonocardiogram (“PKG”) signal when ...

PACING MODE SWITCHING AND RATE RESPONSE LIMIT IN A VENTRICULAR PACEMAKER

An intracardiac ventricular pacemaker having a motion sensor, a pulse generator and a control circuit coupled to the pulse generator and the motion sensor is configured to identify a ventricular systolic event, detect a ventricular passive filling event signal from the motion signal, and determine a time interval from the ventricular systolic event to the ventricular passive filling event. The pacemaker establishes a minimum pacing interval based on the time interval. 1. A medical device , comprising:a pulse generator configured to deliver cardiac pacing pulses;a motion sensor configured to produce a motion signal; identify a ventricular systolic event;', 'detect a ventricular passive filling event signal from the motion signal;', 'determine a time interval from the ventricular systolic event to the ventricular passive filling event; and', 'establish a minimum rate response pacing interval based on the time interval from the ventricular systolic event to the ventricular passive filling event, the minimum rate response pacing interval corresponding to a maximum pacing rate; and, 'a control circuit coupled to the motion sensor and the pulse generator, the control circuit configured toa memory in communication with the control circuit and configured to store the minimum rate response pacing interval.2. The medical device of claim 1 , wherein: determine a sensor indicated pacing rate interval; and', 'determine that the sensor indicated pacing rate interval is less than the minimum pacing interval;, 'the control circuit is further configured tothe pulse generator is configured to deliver a pacing pulse at the minimum pacing interval corresponding to the maximum pacing rate in response to the sensor indicated pacing rate interval being less than the minimum pacing interval.3. The medical device of claim 2 , wherein the control circuit is further configured to determine the sensor indicated pacing rate interval based on the motion signal.4. The medical device of claim 3 , ...

Apparatus and method for outputting heart sounds

An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. in this case, outputs representing the cardiac electrical signals are also output.

External defibrillator

An external defibrillator includes patient electrodes ( 20 ) for obtaining the patient's electrocardiogram (ECG) and for applying a shock to the patient. A microprocessor ( 24 ) analyses the patient's ECU using a diagnostic algorithm to detect if the patient's heart is in a shockable rhythm, and shock delivery circuitry ( 10 ) is enabled when a shockable rhythm is detected by the diagnostic algorithm. The patient electrodes also allow obtaining a signal (Z) which is a measure of the patient's transthoracic impedance and the microprocessor is responsive to Z to detect conditions likely to cause the diagnostic algorithm to generate a false detection of a shockable rhythm. If such detection is made, the microprocessor prevents detection of a shockable rhythm by the diagnostic algorithm, at least for a period of time.

GLOBAL HISTOGRAM OF LOCAL CYCLE LENGTH

At least some aspects of the present disclosure is directed to a system for processing cardiac information. The system comprises a processing unit configured to: receive an activation waveform comprising a set of activation waveform data of a plurality of signal sections collected at a plurality of locations; receive a range of window size. The processing unit is further configured to: for each signal section of the plurality of signal sections, determine a set of confidence values, each confidence value corresponding to a window size, by iterating through a plurality of window sizes in the range of window size. The processing unit is further configured to determine one of a plurality of local cycle lengths for the each of the plurality of signal sections based on the selected window size and generate a local cycle length histogram based on the plurality of local cycle lengths. 1. A method of processing cardiac information , comprising:receiving an activation waveform comprising a set of activation waveform data of a plurality of signal sections collected at a plurality of locations;receiving a set of window parameters comprising a range of window size;{'claim-text': ['determining a set of confidence values, each confidence value corresponding to a window size, by iterating through a plurality of window sizes in the range of window size;', {'claim-text': ['selecting a position of a central window, the central window having the each window size;', 'calculating a set of correlations, each of the set of correlations being a correlation of the activation waveform in the central window and the activation waveform in a shifted window, the shifted window being a sample window shifted from the central window and having the each window size; and', 'determining one of the set of confidence values based on the set of correlations; and'], '#text': 'for each window size of the plurality of window sizes,'}, 'comparing the set of confidence values to select a designated confidence ...

Method of exploring or mapping internal cardiac structures

Methods and systems for mapping and displaying cardiac structures are disclosed. The method includes sensing cardiac electrical signals at a plurality of points and generating a cardiac map of at least a portion of one or more cardiac structures based on at least a portion of the sensed cardiac electrical signals. A surface map having a corresponding first position relative to the cardiac map is generated. The surface map includes a first surface point, where a first cardiac electrical signal feature is represented on the surface map at the first surface point if a corresponding first cardiac electrical signal is sensed at a point that is located within a threshold distance of the first surface point. The cardiac map and the surface map, at the first position, are displayed. The surface map may be repositioned to a second position.

APPARATUS, METHOD, AND COMPUTER-READABLE RECORDING MEDIUM FOR MEASURING SIZE OF ELECTROCARDIOGRAPHY SIGNAL USING ELECTROCARDIOGRAPHY SIGNAL USING HILBERT TRANSFORM

An apparatus for measuring the size of an electrocardiography signal using a Hilbert transform, according to one embodiment of the present invention, may comprise: a receiving unit for receiving a measured electrocardiography signal; a transform unit for Hilbert-transforming the received electrocardiography signal; and a measurement unit for obtaining the size of the electrocardiography signal on the basis of the Hilbert-transformed electrocardiography signal. 1. An apparatus for measuring a size of an electrocardiography signal using a Hilbert transform , the apparatus comprising:a receiving unit for receiving a measured electrocardiography signal;a transform unit for Hilbert-transforming the received electrocardiography signal; anda measurement unit for obtaining the size of the electrocardiography signal based on the Hilbert-transformed electrocardiography signal.2. The apparatus of claim 1 , wherein the measurement unit includes:a first module for creating a Nyquist diagram, which is a time response curve in which a value of the electrocardiography signal is a real value and a value of the Hilbert-transformed electrocardiography signal is an imaginary value;a second module for fitting the created Nyquist diagram by using circle fitting; anda third module for obtaining a diameter of a circle formed on the fitted Nyquist diagram as the size of the electrocardiography signal.3. The apparatus of claim 2 , wherein the diameter of the circle formed on the fitted Nyquist diagram is proportional to sizes of a P wave claim 2 , an R wave claim 2 , and a T wave of the electrocardiography signal.4. The apparatus of claim 2 , wherein the third module is configured to:obtain a diameter of a first circle corresponding to a first curve shape formed at an earliest time among curve shapes included in the Nyquist diagram as a size of a P wave of the electrocardiography signal;obtain a diameter of a second circle corresponding to a second curve shape formed at a later time than the ...

METHODS AND SYSTEMS TO QUANTIFY AND REMOVE ASYNCHRONOUS NOISE IN BIOPHYSICAL SIGNALS

The exemplified methods and systems described herein facilitate the quantification and/or removal of asynchronous noise, such as muscle artifact noise contamination, to more accurately assess complex nonlinear variabilities in quasi-periodic biophysical-signal systems such as those in acquired cardiac signals, brain signals, etc. 1. A method to filter asynchronous noise from an acquired biophysical-signal data set , the method comprising:receiving, by a processor, a biophysical-signal data set of a subject;determining, by the processor, at least one template-signal vector data set characteristic of a representative quasi-periodic signal pattern of the subject from a plurality of detected quasi-periodic cycles detected in the received biophysical-signal data set;applying, by the processor, the at least one determined template-signal vector data set to one or more denoising vector data sets,; andgenerating a filtered biophysical-signal data set of the biophysical-signal data set, or a portion thereof, by merging the portion of the received biophysical-signal data set to be filtered and the one or more generated denoising vector data sets.230-. (canceled) This application claims to, and the benefit of, U.S. Provisional Application No. 62/686,245, filed Jun. 18, 2018, titled “METHODS AND SYSTEMS TO QUANTIFY AND REMOVE ASYNCHRONOUS NOISE IN BIOPHYSICAL SIGNALS,” which is incorporated by reference herein in its entirety.The present disclosure generally relates to non-invasive methods and systems for characterizing cardiovascular circulation and other physiological systems. More specifically, in an aspect, the present disclosure relates to the filtering of asynchronous noise from an acquired biophysical signal (e.g., a cardiac signal, a brain signal, etc.). In another aspect, the present disclosure relates to the quality assessment of an acquired signal and the gating of the acquired signal for analysis. In another aspect, the present disclosure relates to normalizing a ...

Implantable medical systems, devices, and methods for affecting cardiac function through diaphragm stimulation, and for monitoring diaphragmatic health

Devices, systems and methods provide forms of asymptomatic diaphragmatic stimulation (ADS) therapy that affect pressures within the intrathoracic cavity, including: 1) dual-pulse ADS therapy, during which a first ADS pulse is delivered during a diastolic phase of a cardiac cycle and a second ADS pulse is delivered during a systolic phase, 2) paired-pulse ADS therapy, during which a first ADS pulse is delivered, closely followed by a second ADS pulse, with the second ADS pulse functioning to extend or enhance a phase of a transient, partial contraction of the diaphragm, and 3) multiple-pulse ADS therapy, during which a stream of ADS pulses is delivered, wherein the time between pulses is based on heart rate. Devices, systems and methods also monitor electromyography (EMG) activity of the diaphragm relative to baseline activity to assess the health of a diaphragm subject to ADS therapy and to adjust ADS therapy parameters or sensing parameters.

System and method for crossing a native heart valve with a guidewire

A system for crossing a heart valve with a guidewire includes an advancement motor and a controller. The controller controls when the advancement motor advances and retracts the guidewire. The controller is coupled to an electrocardiogram device and determines the systolic and diastolic phase of the heart from information/data from the electrocardiogram device. The guidewire advances or retracts based on the controller's determination of the systolic or diastolic phase corresponding with the heart valve being in an open configuration. The system may include a catheter including a lumen through which the guidewire is disposed. The system may further include a sensor. The sensor is in communication with the controller, and the controller will stop advancement of the guidewire if the controller determines the guidewire has not advanced between open leaflets of the heart valve based upon information/data from the sensor.

Multi-site pacing capture verification

Systems and methods for evaluating electrostimulation of a heart are disclosed. A system can comprise an electrostimulation circuit that can deliver multi-site electrostimulation, including pacing at two or more sites of the heart during the same cardiac cycle. The system can comprise a heart sound sensor circuit configured to sense a heart sound (HS) signal during multi-site stimulation. The heart sound sensor circuit can also sense HS signals in response to uni-site stimulation at a specified site capturing at least a portion of the heart. The system can comprise a pacing analyzer circuit that uses the HS signals during the multi-site stimulation and during the uni-site stimulation to determine a capture status indication that indicates whether the multi-site stimulation captures the two or more sites of the heart, and can be one of a full capture indication, a partial capture indication, or a loss of capture indication.

Systems and Methods for Guidance and Placement of an Intravascular Device

A guidance and placement system and associated methods for assisting a clinician in the placement of a catheter or other medical device within the vasculature of a patient is disclosed. In one embodiment, a method for guiding a medical device to a desired location within a vasculature of a patient is also disclosed and comprises detecting an intravascular ECG signal of the patient and identifying a P-wave of a waveform of the intravascular ECG signal, wherein the P-wave varies according to proximity of the medical device to the desired location. The method further comprises determining whether the identified P-wave is elevated, determining a deflection value of the identified P-wave when the identified P-wave is elevated, and reporting information relating to a location of the medical device within the patient's vasculature at least partially according to the determined deflection value of the elevated P-wave.

Estimating restitution curves in an anatomical mapping system

A method for mapping an anatomical structure includes sensing activation signals of physiological activity with a plurality of electrodes disposed in or near the anatomical structure, each activation signal having an associated cycle length, estimating an action potential duration and diastolic interval for each cycle length, generating a restitution curve based on the estimated action potential duration and diastolic interval from a preceding cycle length, iteratively optimizing each estimated action potential duration and corresponding diastolic interval to maximize a functional relationship between the estimated action potential duration and estimated diastolic interval from preceding cycle length, and generating an action potential duration restitution curve based on the optimized action potential durations and diastolic intervals.

RESILIENT BODY COMPONENT CONTACT FOR A SUBCUTANEOUS DEVICE

A subcutaneously implantable device is implantable into a body of a patient, and includes a prong and an electrode. The prong has a contact portion at or adjacent to a distal end thereof that is configured to contact an organ, a nerve, and/or a tissue of the patient. The prong is constructed to apply pressure to the organ, the nerve, and/or the tissue so as to maintain contact between the contact portion and the organ, the nerve, and/or the tissue without fixing the contact portion to the organ, the nerve, and/or the tissue. The electrode is provided at the contact portion of the prong, is configured to contact the organ, the nerve, and/or the tissue, and is electrically coupled or couplable with circuitry that is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ, the nerve, and/or the tissue. 1. A subcutaneously implantable device comprising:a housing that is implantable into a body of a patient;a prong attached to the housing at a proximal end of the prong, the prong having a contact portion at or adjacent to a distal end of the prong that is configured to contact an organ, a nerve, a first tissue and/or a second tissue of the patient, wherein the prong is constructed to apply pressure to the organ, the nerve, the first tissue and/or the second tissue so as to maintain contact between the contact portion and the organ, the nerve, the first tissue and/or the second tissue without fixing the contact portion to the organ, the nerve, the first tissue and/or the second tissue;an electrode at the contact portion of the prong, the electrode being configured to contact the organ, the nerve, the first tissue and/or the second tissue, and being electrically coupled or couplable with circuitry that is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ, the nerve, the first tissue and/or the second tissue.2. The device of claim 1 , further comprising a clip attached to ...

Electrocardiogram (ecg) signal based authentication apparatus and method

An authentication apparatus includes one or more processors configured to temporally implement a neural network, used to extract a feature value from hidden nodes, that is connected to input nodes to which an electrocardiogram (ECG) signal is input so as to share a weight set with the input nodes, and to match the ECG signal and the extracted feature value to a user for registration.

Filtering noise from a signal subjected to blanking

The disclosure describes techniques and systems for filtering noise from a physiological signal. In one example, one or more processors are configured to receive a signal indicative of physiological activity of a patient, wherein the signal comprises noise at one or more frequencies, and filter the noise from the signal according to a noise rejection model, wherein the noise rejection model predicts the noise at the one or more frequencies. The one or more processors may also be configured to, responsive to initiation of a blanking period for the signal, advance the noise rejection model in time during the blanking period, and, responsive to termination of the blanking period, filter, based on the noise rejection model advanced in time, the noise at the one or more frequencies from the signal.

TRI-AXIAL SEISMOCARDIOGRAPHY DEVICES AND METHODS

A computer-implemented method may comprise providing a wireless tri-axial seismocardiography (SCG) device configured to measure and time-stamp movements of a user's chest caused by the user's heart beats; positioning the SCG device on the user's chest in a predetermined orientation and initiating a test; using the positioned SCG device, detecting, sampling, digitizing and time-stamping movement vectors of the user's chest over a predetermined period of time in each of x, y and z directions; storing the time-stamped digitized movement vectors in a memory of the SCG device and sending the time-stamped digitized movement vectors to at least one of the app on the mobile device and the remote server over a computer network; receiving, by the app on the mobile device, a plurality of fiduciary markers from the remote server, the plurality of fiduciary markers being detected from or derived using the time-stamped digitized movement vectors in each of x, y and z directions; and generating a report on the mobile device using at least some of the plurality of fiduciary markers, the report including an indication of the health of the user's heart. 1. A computer-implemented method , comprising:providing a wireless tri-axial seismocardiography (SCG) device configured to measure and time-stamp movements of a user's chest caused by the user's heart beats;positioning the SCG device on the user's chest in a predetermined orientation and initiating a test;using the positioned SCG device, detecting, sampling, digitizing and time-stamping movement vectors of the user's chest over a predetermined period of time in each of x, y and z directions;storing the time-stamped digitized movement vectors in a memory of the SCG device and sending the time-stamped digitized movement vectors to at least one of the app on the mobile device and the remote server over a computer network;receiving, by the app on the mobile device, a plurality of fiduciary markers from the remote server, the plurality of ...

TRI-AXIAL SEISMOCARDIOGRAPHY DEVICES AND METHODS

A computer-implemented method may comprise providing a wireless tri-axial seismocardiography (SCG) device configured to measure and time-stamp movements of a user's chest caused by the user's heart beats; positioning the SCG device on the user's chest in a predetermined orientation and initiating a test; using the positioned SCG device, detecting, sampling, digitizing and time-stamping movement vectors of the user's chest over a predetermined period of time in each of x, y and z directions; storing the time-stamped digitized movement vectors in a memory of the SCG device and sending the time-stamped digitized movement vectors to at least one of the app on the mobile device and the remote server over a computer network; receiving, by the app on the mobile device, a plurality of fiduciary markers from the remote server, the plurality of fiduciary markers being detected from or derived using the time-stamped digitized movement vectors in each of x, y and z directions; and generating a report on the mobile device using at least some of the plurality of fiduciary markers, the report including an indication of the health of the user's heart. 1. A computer-implemented method , comprising:providing at least one wireless tri-axial seismocardiography (SCG) device configured to measure and time-stamp movements of a user's chest caused by the user's heart beats; ["positioning the SCG device on the user's chest;", "using the positioned SCG device, detecting, sampling, digitizing and time-stamping movement vectors of the user's chest over a period of time in each of x, y and z directions;", 'sending the time-stamped digitized movement vectors to a remote server over a computer network;', 'identifying and storing, by the remote server, a set of fiduciary markers in each test using the time-stamped digitized movement vectors in each of x, y and z directions;, 'using the provided at least one SCG device, carrying out at least one test for each of a plurality of users, each test ...

System and Method for Electrophysiological Mapping

An electrophysiology map of a portion of a patient's anatomy can be visualized using an electroanatomical mapping system. The system receives a plurality of electrophysiology data points (e.g., an electrophysiology map), which includes a plurality of electrophysiology signals. The system then creates a distribution (e.g., a histogram) for one or more characteristics of the plurality of electrophysiology signals (e.g., dominant cycle length, regular cycle length, peak-to-peak voltage, fractionation, conduction velocity, or the like). The system then analyzes the distribution to determine a display convention (e.g., a range and scale) for a graphical representation of the characteristic based on, for example, a best-fit shape of the distribution, a skew of the distribution, a range of the distribution, and/or a most dominant value of the distribution. The graphical representation can then be output according to the display convention. 1. A method of visualizing an electrophysiology map of a portion of a patient's anatomy using an electroanatomical mapping system , the method comprising:the electroanatomical mapping system receiving a plurality of electrophysiology data points, the plurality of electrophysiology data points comprising a plurality of electrophysiology signals;the electroanatomical mapping system analyzing the plurality of electrophysiology signals to determine a distribution for at least one characteristic of the plurality of electrophysiology signals;the electroanatomical mapping outputting a graphical representation of the at least one characteristic of the plurality of electrophysiology signals, wherein a display convention for the graphical representation is determined according to the distribution for the at least one characteristic of the plurality of electrophysiology signals.2. The method according to claim 1 , wherein analyzing the plurality of electrophysiological signals to determine a distribution for at least one characteristic of the ...

System and Method for Distinguishing a Cardiac Event From Noise in an Electrocardiogram (ECG) Signal

A system includes an ambulatory medical device and a server. The ambulatory medical device comprises: a digital signal processing module configured to: detect an abnormal rhythm from an electrocardiogram (ECG) signal of a patient using a first signal processing routine; and generate a first flag indicating an abnormal rhythm is detected; and a noise detector module configured to: receive the ECG signal from the digital signal processing module; execute a second signal processing routine to classify the abnormal rhythm as one of an arrhythmia event and a noise event; and, if the abnormal rhythm is classified as a noise event, initiate a preconfirmation period during which the noise detector module continues to evaluate the abnormal rhythm and classify the abnormal rhythm as one of an arrhythmia event and a noise event using the second signal processing routine; and generate a second flag indicating the start of the preconfirmation period; and a server configured to: receive the ECG signal, the first flag indicating the abnormal rhythm, and the second flag indicating the start of the preconfirmation period; and provide a visual indication of the preconfirmation period.

SYSTEMS AND METHODS OF PATIENT DATA COMPRESSION

A system including a medical device is provided. The medical device includes at least one sensor configured to acquire first data descriptive of a patient, first memory storing a plurality of templates, and at least one processor coupled to the at least one sensor and the first memory. The at least one processor is configured to identify a first template of the plurality of templates that is similar to the first data, to determine first difference data based on the first template and the first data, and to store the first difference data in association with the first template. The system may further include the programmable device. 122.-. (canceled)23. A medical device for efficient transmission of patient data , the medical device comprising:at least one sensor configured to acquire electrocardiogram (ECG) data descriptive of a patient condition;at least one memory configured to store a plurality of ECG templates;at least one network interface; and receive current ECG data for the patient from the at least one sensor,', 'compare the current ECG data to a first reference template of the plurality of ECG templates,', 'calculate difference data between the current ECG data and the first reference template,', 'compress the difference data and an identifier of the first reference template to generate compressed data, and', 'transmit the compressed data via the network interface to a programmable device distinct from the medical device., 'at least one processor coupled to the at least one sensor, the at least one memory, and the at least one network interface, the at least one processor configured to24. The medical device of claim 23 , wherein the at least one processor is further configured to:receive initial ECG data for the patient from the at least one sensor; andgenerate the plurality of ECG templates for the patient based upon the initial ECG data, the plurality of ECG templates stored on the memory.25. The medical device of claim 24 , wherein the at least one ...

CARDIAC EVENT SENSING IN AN IMPLANTABLE MEDICAL DEVICE

An implantable medical device performs a method that includes detecting a cardiac event interval that is greater than a P-wave oversensing threshold interval. In response to detecting the cardiac event interval greater than the P-wave oversensing threshold interval, the device determines the amplitude of the sensed cardiac signal and withholds restarting a pacing interval in response to the amplitude satisfying P-wave oversensing criteria. A pacing pulse may be generated in response to the pacing interval expiring without sensing an intrinsic cardiac electrical event that is not detected as a P-wave oversensing event. 1. A medical device comprising: receive at least one cardiac signal;', 'set an R-wave sensing threshold to a starting value;', 'adjust the R-wave sensing threshold from the starting value according to auto-adjusting threshold control parameters;', 'sense a cardiac event in response to the at least one cardiac signal crossing the R-wave sensing threshold; and, 'a sensing circuit configured toa control circuit coupled to the sensing circuit and configured to, in response to the cardiac event sensed by the sensing circuit, determine that P-wave oversensing criteria are met based on the at least one cardiac signal;wherein the sensing circuit is further configured to continue adjusting the R-wave sensing threshold according to the auto-adjusting threshold control parameters in response to the control circuit determining that the P-wave oversensing criteria are met.2. The medical device of claim 1 , wherein the control circuit is further configured to:start a pacing interval; andwithhold restarting of the pacing interval in response to determining that the P-wave oversensing criteria are met.3. The medical device of claim 2 , wherein the control circuit is further configured to detect an expiration of the pacing interval; andfurther comprising a therapy delivery circuit configured to generate a cardiac pacing pulse in response to the expiration of the pacing ...

Method and system for selecting lv pacing site in a multipolar lv lead

A method and system for selecting at least one left ventricular (LV) pacing site for an implantable medical device equipped for cardiac stimulus pacing using a multi-pole LV lead are provided. The method and system include sensing LV activation events at multiple LV sensing sites. The arrival times of the LV activation events for corresponding LV sensing sites are measured. The method and system further include calculating differences between the arrival times for combinations of the LV sensing sites to obtain inter-site arrival delays between the combinations of the LV sensing sites. When at least one of the inter-site arrival delays exceeds a threshold, the method and system include designating the LV sensing site from the corresponding combination that has a later arrival time as a first LV pacing site from which to deliver LV pacing pulses using the implantable medical device.

PROCESSING OF ELECTROPHYSIOLOGICAL SIGNALS

In an embodiment, PhotoPlethysmoGraphy (PPG) signals are processed by detecting peaks and valleys in the PPG signal, segmenting the PPG signal to provide a time series of PPG waveforms located between two subsequent valleys in the PPG signal, applying to the waveforms in the time series pattern recognition with respect to a reference PPG waveform pattern produced based on a mathematical model of the PPG signal by assigning to the waveforms in the time series a recognition score. A resulting PPG signal is produced by retaining the waveforms in the time series having an assigned recognition score reaching a recognition threshold, and discarding the waveforms in the time series having an assigned recognition score failing to reach the recognition threshold. 1. A system comprising:a photoplethysmography (PPG) sensing apparatus configured to receive a PPG signal; and detect peaks and valleys in the PPG signal;', 'segment the PPG signal to provide a first time series of PPG waveforms located between two subsequent valleys in the PPG signal;', 'apply pattern recognition to the first time series with respect to the reference PPG waveform pattern produced based on a mathematical model of the PPG signal by assigning a recognition score to the PPG waveforms in the first time series, the reference PPG waveform pattern being produced with a reaction-diffusion model, with diastolic and systolic phases of a heart coupled with the reaction and diffusion properties of the reaction-diffusion model, and the processor is configured to apply the pattern recognition by being configured to apply cross-correlation analysis between the waveforms in the first time series and the reference PPG waveform pattern; and', 'produce a resulting PPG signal by retaining the waveforms in the first time series having a recognition score higher or equal to a recognition threshold, and discarding the waveforms in the first time series having a recognition score lower than the recognition threshold., 'a ...

DEVICE FOR DETERMINING A PIECE OF INFORMATION RELATING TO A CARDIAC DECOMPENSATION STATE

Disclosed is a device for determining a piece of information relating to a cardiac decompensation state of a user, the information being obtained by analysis of a cardiac parameter, characterized in that it includes a measuring device designed to determine a signal value by means of at least one accelerometer signal curve of the user, the signal value being intended to be compared with an additional signal value originating from a measurement by a cardiac monitor, the measuring device comprising, for this purpose, at least one accelerometer designed to determine said accelerometer signal curve, the measuring device being designed to be housed in an implant inside the user. 1. Device for determining a piece of information relating to a cardiac decompensation state of a user , said information being obtained by analysis of a cardiac parameter , characterized in that it includes at least one measuring device designed to determine a signal value by means of at least one accelerometer signal curve of the user , said signal value being intended to be compared with an additional signal value originating from a measurement by a cardiac monitor , the measuring device comprising , for this purpose , at least one accelerometer designed to determine said accelerometer signal curve of the user , the measuring device being designed to be housed in an implant inside the user.2. Determination device according to claim 1 , comprising a measuring means which is designed for measuring the additional signal value claim 1 , said measuring means comprising at least the cardiac monitor claim 1 , the determination device further comprising a calculation device designed for determining a value of the cardiac parameter depending on the time between the appearances of the signal and of the additional signal claim 1 , the calculation device being designed to compare the cardiac parameter to a threshold value claim 1 , exceeding which reveals a cardiac decompensation.3. Determination device ...

Systems and methods for intravascular catheter positioning and/or nerve stimulation

A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle.

A Probability-Based Detector and Controller Apparatus, Method, Computer Program

An apparatus including circuitry configured to determine a probability by combining at least: a probability that an event is present within a current feature of interest given a first set of previous features of interest, and a probability that the event is present within the current feature of interest given a second set of previous features of interest, different to the first set of previous features of interest; circuitry configured to detect the event based on the determined probability; and circuitry configured to control, in dependence on the detection of the event, performance of an action.

Integrate and fire pulse train automation for qrs detection

Various examples are provided for automation of QRS detection. In one example, among others, a system includes an integrate and fire (IF) sampler that can generate an IF pulse train from an analog input signal, and decision logic circuitry that can determine whether a QRS complex waveform is present in a pulse segment of the IF pulse train. In another example, a method includes generating an integrate and fire (IF) pulse train from an analog input signal, identifying a pulse segment of the IF pulse train, and determining whether a QRS waveform is present in the pulse segment based at least in part upon attributes associated with the pulse segment.

INTERPOLATION OF DYNAMIC THREE-DIMENSIONAL MAPS

A method, including acquiring initial signals from selected positions in a heart, computing respective initial local values of a signal propagation metric at the selected positions, and interpolating the initial local values between the selected positions to compute initial interpolated values of the signal propagation metric at intermediate positions, between the selected positions. The method further includes acquiring subsequent signals from the positions, computing respective subsequent local values of the signal propagation metric at the selected positions, and spatially interpolating the subsequent local values of the signal propagation metric between the selected positions to compute subsequent interpolated values of the signal propagation metric at the intermediate positions. A map of the signal propagation metric is displayed, and when the subsequent interpolated values exceed a bound defined with respect to the initial interpolated values, an indication is provided on the map that the bound has been exceeded. 1. An electrophysiology method , comprising:acquiring an initial set of electrical signals from tissue at selected positions in a heart of a subject, the electrical signals being representative of tissue conductivity;determining, based on the electrical signals in the initial set, respective initial local values of a signal propagation metric at the selected positions for an initial time;spatially interpolating the initial local values of the signal propagation metric between the selected positions to determine initial interpolated values of the signal propagation metric at intermediate positions, between the selected positions, for the initial time;acquiring a subsequent set of electrical signals from the tissue at the selected positions;determining, based on the electrical signals in the subsequent set, respective subsequent local values of the signal propagation metric at the selected positions for a subsequent time;spatially interpolating the ...

SYSTEM AND METHOD FOR ELECTROPHYSIOLOGICAL MAPPING

An electrophysiology map of a portion of a patient's anatomy can be visualized using an electroanatomical mapping system. The system receives a plurality of electrophysiology data points (e.g., an electrophysiology map), which includes a plurality of electrophysiology signals. The system then creates a distribution (e.g., a histogram) for one or more characteristics of the plurality of electrophysiology signals (e.g., dominant cycle length, regular cycle length, peak-to-peak voltage, fractionation, conduction velocity, or the like). The system then analyzes the distribution to determine a display convention (e.g., a range and scale) for a graphical representation of the characteristic based on, for example, a best-fit shape of the distribution, a skew of the distribution, a range of the distribution, and/or a most dominant value of the distribution. The graphical representation can then be output according to the display convention. 120-. (canceled)21. A method of visualizing electrophysiological activity of a portion of a patient's anatomy using an electroanatomical mapping system , the method comprising the electroanatomical mapping system:receiving a plurality of electrophysiology data points, the plurality of electrophysiology data points comprising a plurality of electrophysiology signals;creating a frequency curve of a distribution of values of a characteristic of the plurality of electrophysiology signals; andoutputting a graphical representation of the frequency curve.22. The method according to claim 21 , wherein the characteristic comprises dominant cycle length.23. The method according to claim 21 , wherein the characteristic comprises regular cycle length.24. The method according to claim 21 , wherein the characteristic comprises peak-to-peak voltage.25. The method according to claim 21 , wherein the characteristic comprises fractionation.26. The method according to claim 21 , wherein the characteristic comprises conduction velocity.27. The method ...

Frequency analysis for predicting left ventricular dysfunction

Systems and methods are provided for evaluating infranodal pacing is applied to a patient. Electrocardiogram (ECG) data representing the pacing is obtained from a set of electrodes as an ECG lead. A predictor value representing a frequency content a portion of the ECG lead is extracted. A fitness parameter is determined for the pacing from at least the predictor value. The fitness parameter represents a likelihood that the applied infranodal pacing will induce left ventricular dysfunction in the patient. The fitness parameter is displayed to a user at an associated display.

System and Method for Assisted Partitioning of Body Conduits

A treatment strategy for treatment of elevated pressure in a body conduit, such as a pulmonary vein, with a prosthetic partitioning device for placement in and/or about pulmonary veins is described, as well as delivery systems, and strategies for use thereof. A control device is configured to transmit signals to the prosthetic device to effectuate the repetitive transition between a first, less restricted flow configuration and a second, restricted flow configuration are described. A sensor device may be provided for monitoring physiological parameters of the patient, and can provide signals to the control device for effectuating the transition between the first and second configuration.

CARDIAC PULSE WAVE RETRIEVAL FROM AN ELECTRICAL SIGNAL

The present disclosure relates to a method and a system for determining a pulse wave signal (PWS) of a subject. The method (M) comprises: a step M) of providing an electrocardiographic (ECG) signal (S) of a subject (); a step (M) of providing an electrical signal (S) of the subject (); a step (M) of determining a collection of points of interest (S) in the ECG signal (S); a step (M) of determining a collection of specific points (Sx, Sx) using the collection of points of interest (S); a step (M) of determining a cleaned electrical signal (S) based on the collection of specific points (Sx, Sx); a step (M) of determining a pulse wave signal (PWS) by subtracting the cleaned electrical signal (S) from the electrical signal (S). 1. A method for determining a pulse wave signal of a subject , the method comprising:a step of providing an electrocardiographic, ECG, signal of a subject by means of one or more sensors;a step of providing an electrical signal of the subject by means of one or more sensors;a step of determining a collection of points of interest in the ECG signal;a step of determining a collection of specific points in the electrical signal using the collection of points of interest, wherein the determined collection of specific points includes two or more specific points in the electrical signal;a step of determining a cleaned electrical signal based on the collection of specific points;a step of determining a pulse wave signal by subtracting the cleaned electrical signal from the electrical signal, wherein the collection of specific points in the electrical signal are determined based on timestamps of the collection of points of interest in the ECG signal and at least one of the two or more specific points in the electrical signal for every heartbeat response indicated in the ECG signal is associated with a timestamp offset in time relative to the timestamp of the corresponding point of interest in the ECG signal.2. The method according to claim 1 , wherein ...

Leadless intra-cardiac medical device with dual chamber sensing through electrical and/or mechanical sensing

A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).

Methods and systems for storage, retrieval, and visualization of signals and signal features

An implantable device includes a memory and a processor coupled to the memory and configured to perform actions, including: receiving electrical signals from tissue of a patient; and in response to each of a plurality of triggers, storing a portion of the received electrical signals, occurring after the trigger and extending for a limited duration, in the memory on a first-in-first-out basis. Another an implantable device includes a memory; and a processor coupled to the memory and configured to perform actions, including: receiving electrical signals from tissue of a patient; and in response to each of a plurality of triggers, determining at least one feature of the received electrical signals; and storing the at least one feature in the memory on a first-in-first-out basis.

Method for determining and monitoring a cardiac status of a patient

The present invention relates to a method for accurately and reliably determining a cardiac status of a patient. An implantable medical device, IMD, comprises a sensor arrangement adapted to sense signals related to mechanical activity of the heart and an activity level sensor arrangement adapted to sense an activity level of the patient. Further, the IMD calculates a percentage of left ventricular diastolic time (PLVDT) for a cardiac cycle corresponding to a relation between a diastolic time interval and a cardiac cycle time interval using the determined systolic and diastolic time intervals or a percentage of left ventricular systolic time (PLVST) for a cardiac cycle corresponding to a relation between a systolic interval time interval and a cardiac cycle time interval using. A cardiac status is determined based on the calculated PLVDT (or PLVST) and on an activity level of the patient.

APPARATUS AND A METHOD FOR MONITORING A PATIENT DURING HIS SLEEP

A method for monitoring a patient during his sleep, comprising: monitoring the thoracic breath of the patient; monitoring the abdominal breath of the patient; detecting a sleep apnea syndrome (SAS) event (); in reaction to the detection of N such SAS events, N being an integer equal or larger than 1, performing an additional measurement () to detect an abnormal condition. 1. A method for monitoring a patient during his sleep , comprising:monitoring the thoracic breath of the patient;monitoring the abdominal breath of the patient;detecting a sleep apnea syndrome (SAS) event;in reaction to the detection of N such SAS events, N being an integer equal or larger than 1, performing an additional measure to detect an abnormal condition.2. The method of claim 1 , wherein an alarm is sent in reaction to said detection of an abnormal condition.3. The method of claim 1 , wherein said additional measure comprises a heart measure.4. The method of claim 3 , wherein said heart leasure comprises a detection of an unexpected increase or decrease in the heart rate.5. The method of claim 3 , wherein said heart measure comprises a detection of arrhythmia.6. The method of claim 3 , wherein said heart measure comprises an electrocardiogram.7. The method of claim 1 , said additional measure comprising an evaluation of the oxygenation of the blood.8. The method of claim 1 , wherein said additional measure comprises an encephalogram.9. The method of claim 1 , said detection of N SAS events comprising a detection of N such events longer than a predetermined threshold.10. The method of claim 1 , wherein said additional measure comprises a measure of the body position after said event andior a. detection of body movements after said event.11. The method of claim 2 , said alarm being sent over a radiofrequency short distance interface to a proprietary claim 2 , dedicated base station.12. The method of claim 1 , wherein the detection of a SAS event and the decision to perform an additional ...

Automatic Orientation Of Subcutaneous ECG In Implantable Monitoring Devices

Various embodiments are directed toward a system and method for determining an orientation of an implantable medical device (“IMD”) and automatically adjusting a subcutaneous electrocardiogram (“ECG”) signal based on the determined orientation. The method can further include tagging generated SECG signals so as to identify whether a SECG signal had been generated from an implantable monitoring device with its first electrode being superior or inferior relative to its second electrode. Further embodiments can include automatically adjusting the orientation of the generated SECG signals to match that of a preferred orientation.

Heart Electrophysiological Signal Analysis System

A system automatically detects and measures ST deviation of a heart wave ECG signal in the presence of noise and accommodates baseline variation of the signal and other artifacts. A system identifies a particular point in an electrophysiological signal representing heart electrical activity using an interface for receiving an electrical signal waveform comprising an R-wave and including an ST segment portion associated with heart electrical activity of a patient over a heart beat cycle. A signal processor processes data representing the electrical signal waveform by identifying an S point and T point in the electrical signal waveform and determining a first candidate J point in the electrical signal waveform having substantially a maximum distance from a line between the identified S and T points, the distance being measured perpendicularly to the line.

SYSTEM AND METHOD FOR TEMPORAL SPARSE PROMOTING IMAGING OF CARDIAC ACTIVATION

A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction. 123-. (canceled)24. A system for cardiac activation imaging , the system comprising:at least one data acquisition device to acquire data relating to an electrical activation of a heart of a subject; and receive the data acquired by the at least one data acquisition device, and', 'the reconstruction being based on a temporally sparse estimate of an amplitude of current density.', 'generate a cardiac electrical activation image based on reconstructing an activation image of the heart of the subject based on the acquired data and a weighted sparse constrained reconstruction,'}], 'a processor configured to25. The system of claim 24 , wherein the weighted sparse constrained reconstruction is non-sparse in a spatial domain and incorporates 4D spatiotemporal cardiac dynamics.26. The system of claim 24 , wherein the processor claim 24 , when reconstructing the activation image of the heart of the subject claim 24 , is further configured to:{'sub': 't,i', 'claim-text': {'sub': 't,i', 'wherein the plurality of weights Wprovide stability to the weighted sparse constrained reconstruction.'}, 'reconstruct the activation image of the heart of the subject based on a plurality of weights Wrepresenting temporal weights of time instant t at location grid point i,'}27. The system of claim 26 , wherein the plurality of weights Ware selected to provide at least one of a reduced smearing effect and a reduced distortion to the reconstructed activation image than a minimum norm solution.28. The system of claim 26 , wherein the processor claim 26 , when reconstructing the activation image of the heart of the subject claim 26 , is further configured to:{'sub': 't,i', 'claim-text': [{' ...

Predictive instrument to identify patients for use of pharmacological cardiac metabolic support

A purpose-made predictive instrument for the administration of cardiac metabolic support for acute coronary syndromes (ACS, which include unstable angina and acute myocardial infarction) that particularly identifies those most likely to benefit from treatment. In some examples, such a predictive instrument is used for real-time decision support for the administration of treatments such as glucoseinsulin-potassium (GIK).

Assessing intra-cardiac activation patterns

Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

Shock determination based on prior shocks

A system for managing care of a person receiving emergency cardiac assistance is disclosed that includes one or more capacitors for delivering a defibrillating shock to a patient; one or more electronic ports for receiving signals from sensors for obtaining indications of an electrocardiogram (ECG) for the patient; a patient treatment module executable on one or more computer processors to provide a determination of a likelihood of success from delivering a future defibrillating shock to the person with the one or more capacitors, using (a) information about a prior defibrillating shock, and (b) a value that is a function of current ECG signals from the patient.

HEMODYNAMIC PERFORMANCE ENHANCEMENT THROUGH ASYMPTOMATIC DIAPHRAGM STIMULATION

An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation. The circuit structure includes accelerometer-linked computer structure for enabling selective review, for later operational modifications, of stimulation-produced diaphragmatic motions, and in a modified form, may additionally include timing-adjustment substructure capable of making adjustments in the mentioned timed relationships. 1. An implantable medical system comprising:a plurality of electrodes configured for placement adjacent to a diaphragm or in direct contact with a diaphragm; and obtain sensed cardiac activity corresponding to sensed electrical cardiac activity through one or more of the plurality of electrodes,', 'detect a cardiac event in a cardiac cycle based on the sensed cardiac activity, and', 'apply an electrical stimulation to at least one of the plurality of electrodes in a timed relationship relative to the detected cardiac event., 'a circuit structure coupled to the plurality of electrodes and configured to2. The implantable medical system of claim 1 , wherein the cardiac event corresponds to one of a R wave and a Q wave.3. The implantable medical system of claim 1 , wherein the electrical stimulation comprises a single pulse configured to induce a singular asymptomatic ...

Intravascular optical imaging system

A catheter-based optical imaging system for imaging a patient includes a catheter-based imaging device configured to direct optical radiation towards a vessel wall and to receive reflected radiation therefrom. A displacement mechanism is configured to vary the position of the imaging device relative to the catheter as a function of time during an imaging scan. An input is configured to receive cardiac event timing data, such as ECG data, from the patient. A trigger module is configured to initiate an imaging scan based on the cardiac event timing obtained from the cardiac event timing data. By triggering the optical imaging scans between cardiac events, artefacts in the image data can be reduced or eliminated.

System and Method for Rapid ECG Acquisition

In one embodiment, an ECG monitoring system includes two or more electrodes configured to record cardiac potentials from a patient, at least one processor, and a rapid acquisition module executable on the at least one processor to: determine that an impedance of each electrode is less than an impedance threshold; record initial ECG lead data based on the cardiac potentials; determine that a noise level in each ECG lead of the initial ECG data is less than a noise threshold; start a recording timer once the noise level is below the noise threshold; record an ECG dataset while the noise level is maintained below the noise threshold until the recording timer reaches a predetermined test duration; store the ECG dataset and provide a completion alert.

Mobile phone for treating a patient with seizures

Devices, systems and methods are disclosed that allow a patient to self-treat epileptic seizures by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.

Sampling intrinsic av conduction time

Methods and/or devices for sampling a patient's intrinsic AV conduction time during cardiac therapy that may, e.g., change the AV delays to values based on the AV delays themselves, previously-sampled intrinsic AV conduction times, and/or one or more other parameters directly related to AV delays to provide a time period during which to measure the patient's intrinsic AV conduction time.

Cardiac conduction system engagement

Systems and methods are described herein for determining whether a patient's cardiac conduction system or portions thereof are engaged by cardiac conduction system pacing therapy. One or more local metrics of electrical heterogeneity information may be generated based on surrogate cardiac electrical measured using a plurality of local external electrodes, which may be used to determine whether the patient's cardiac conduction system is engaged.

Implantable cardiac systems with baseline correction in response to noise detection

Implantable cardiac devices and methods of their use. A method of operation in an implantable cardiac device may include steps for characterizing detected events as noise or not noise, identifying a set of consecutive noise events or a threshold quantity of noise events in a set period of time and declaring a noisy series to have occurred. In response to the declaration of a noisy series, the method initiates a baseline correction algorithm. Devices for performing such methods are also disclosed.

Ecg signal processor, personal identification system, and ecg signal processing method

ECG signal processor includes: a signal processing circuit configured to amplify an ECG signal detected by an electrode attached to a living body and output the ECG signal amplified; and a common-mode signal generation circuit configured to generate a common-mode signal for increasing an amplitude of a peak of the ECG waveform indicated by the ECG signal using the ECG signal amplified by the signal processing circuit and apply the common-mode signal generated to the electrode.

INTRAVASCULAR CATHETER METHODS

A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle. 130-. (canceled)31. A method for operating a catheter , the method comprising:positioning the catheter in a vascular system of a patient, wherein the catheter includes a plurality of electrodes;acquiring a first ECG signal and a second ECG signal, via one or more first electrodes of the plurality of electrodes;determining a difference between the first ECG signal and the second ECG signal;based on the difference, repositioning the catheter within the vascular system of the patient; andstimulating a phrenic nerve via one or more second electrodes of the plurality of electrodes.32. The method of claim 31 , wherein stimulating the phrenic nerve includes stimulating a left phrenic nerve claim 31 , and the method further comprises stimulating a right phrenic nerve.33. The method of claim 31 , wherein repositioning includes moving the catheter from a first position to a second position; anda distal tip of the catheter is farther from a heart of the patient when the catheter is in the second position, compared to the first position.34. The method of claim 31 , wherein positioning the catheter in the ...

METHODS, SYSTEMS AND MEDIA FOR RECONSTRUCTING BIOELECTRONIC LEAD PLACEMENT

Methods, systems, and media are disclosed for reconstructing bioelectronic lead placement. In some embodiments, the disclosed system can include a processor configured to determine relationships between EP signals of one or more pairs of a plurality of electrodes over one or more sampling time periods, wherein the plurality electrodes are separately placed on a patient's body for collecting the EP signals, and to reconstruct geometry of the plurality of electrodes based on the relationships between the EP signals. 1. A system for reconstructing bioelectronic lead placement , comprising: ["receive EP signals from a plurality of electrodes, the plurality of electrodes having been positioned on a patient's body for collection of the EP signals;", 'determine relationships between the EP signals from one or more pairs of the plurality of electrodes over one or more sampling time periods; and', 'reconstruct a geometry of the plurality of electrodes based on the relationships between the EP signals., 'a processor configured to2. The system of claim 1 , wherein the plurality of electrodes includes surface electrodes configured to collect surface electrocardiogram (SECG) signals.3. The system of claim 1 , wherein the plurality of electrodes include intracardiac electrodes configured to collect intracardiac electrocardiogram (IECG) signals.4. The system of claim 1 , wherein the processor is further configured to determine biological signaling time latencies between the EP signals from the one or more pairs of the plurality of electrodes.5. The system of claim 1 , wherein the processor is further configured to determine Pearson correlation coefficients between the EP signals from the one or more pairs of the plurality of electrodes.6. The system of claim 1 , wherein the processor is further configured to fit the relationships to a weighted graph in which the plurality of electrode are nodes and the relationships are edges.7. The system of claim 6 , wherein the processor is ...

Annotation waveform

Systems and methods for processing cardiac information include a processing unit configured to receive a set of cardiac electrical signals; receive an indication of a measurement location corresponding to each of the set of electrical signals; and identify, for each electrical signal of the set of electrical signals, a deflection. The deflection includes a deviation from a signal baseline. An activation waveform corresponding to the set of electrical signals is generated based on the identified deflections.

Leadless pacing system including sensing extension

A leadless pacing system includes a leadless pacing device and a sensing extension extending from a housing of the leadless pacing device. The sensing extension includes one or more electrodes with which the leadless pacing device may sense electrical cardiac activity. The one or more electrodes of the sensing extension may be carried by a self-supporting body that is configured to passively position the one or more electrodes proximate or within a chamber of the heart other than the chamber in which the LPD is implanted.

Estimating distribution, fluctuation and/or movement of electrical activity through a heart tissue

A computer implemented method for processing measurement data from electrocardiogram, ECG, electrodes on a subject. The method includes obtaining a 3D anatomical model of the torso of the subject, and obtaining a 3D image of the torso of the subject. The three dimensional image is aligned with the three-dimensional model. A position of each electrode in the three-dimensional model is determined from the three dimensional image. The positions of the electrodes in the three dimensional model are used for estimating the distribution, fluctuation and/or movement of electrical activity through heart tissue.

Methods and Apparatus to Stimulate Heart Atria

A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.