ПРОИЗВОДНЫЕ ГИДРОКСИЛАМИНА, ПРИГОДНЫЕ ДЛЯ УСИЛЕНИЯ ОБРАЗОВАНИЯ МОЛЕКУЛЯРНОГО ШАПЕРОНА, И ИХ ПОЛУЧЕНИЕ

Изобретение относится к области медицины и касается способа повышения экспрессии молекулярного шаперона клеткой и/или повышения активности молекулярного шаперона в клетках путем обработки клетки эффективным количеством производного гидроксиламина формулы (I) или (II), а также к новым производным гидроксиламина и фармкомпозициям на их основе. Изобретение позволяет эффективно регулировать клеточные процессы. 13 с. и 132 з.п.ф-лы, 29 ил., 5 табл.

Микробиоцидное средство

Способ получения производных -изонитрозоацетофенона

SUBSTITUTED ALKANYL-AZOLYL CARBAMATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES, ACARICIDES AND NEMATOCIDES

NEUE O-(3-AMINO-2-HYDROXYPROPYL)-HYDROXIMSÄUREHALOGENIDE UND VERFAHREN ZUR HERSTELLUNG DERSELBEN.

Substituted 2-phenyl-3-methoxypropenoate fungicides

Procoss for preparing -(3-a ino-2-hydroxy-propyl)-hydroxymic acid halides

Process for preparing 0-(3-Amino-2-hydroxy-propyl)-hydroxymic and halides.

The present invention relates to a novel process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides of formula (i)by by reacting a carboxamide oxime of formula (ii)wherein r1 is as specified above with reactive 3-amino-2-hydroxy-propane derivative, diazotizing the o-substituted carboxamide oxime thus obtained with sodium nitrite in the presence of hydrogen halide, decomposing the diazonium salt and if desired, separating the optically active enantiomers and/or reacting the resulting base with an organic or mineral acid, wherein the carboxamide oxime of formula (ii)is reacted with a 3-hydroxy azetidinium salt of formula (iii)wherein r2 and r3 are as defined above and y- is a salt forming anion, in a lower alcoholic, preferably ethanolic medium optionally containing water and made alkaline with an alkali hydroxide, and before diazotizing the o-substituted carboxamide axime intermediate obtained, the reaction mixture is neutralised and the organic solvent is removed. The process ...

New oxime carbamates, their preparation, compositions the container, and their use as pesticides.

Agents supporting the growth of the plants and phytoprotecteurs containing oximeters and oximesters.

Fungicides.

PLANT-STATURE-PROMOTING AND PLANT-PROTECTING MEANS

PROCEDURE FOR THE PRODUCTION OF NEW CEPHALOSPORINEN AND PENICILLINEN

PROCEDURE FOR THE PRODUCTION OF ISOXAZOLYL BETA LACTAM ANTIBIOTICS

INSECTICIDE, AKARIZIDES AND NEMATIZIDES MEANS

PLANT-STATURE-PROMOTING AND PLANT-PROTECTING MEANS ON BASIS OF OXIMAETHERN AND - ESTERS

SUBSTITUTED PHENOXYMETHYLPHENYL DERIVATIVES, PROCEDURES FOR YOUR PRODUCTION AND YOUR USE FOR THE FIGHT AGAINST PARASITS AND MUSHROOMS

PROCEDURE FOR THE PRODUCTION OF NEW CEPHALOSPORINEN AND PENICILLINEN

Procedure for the production of new Aminopenicillansäurederivaten

HYDROXIMSÄUREDERIVATE, THESE CONTAINING PHARMACEUTICAL PREPARATIONS AND PROCEDURES FOR THEIR PRODUCTION

VERFAHREN ZUR HERSTELLUNG VON NEUEN CEPHALOSPORINEN UND PENICILLINEN

OXIME DERIVATIVES

ISOCYANATES

Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

N-SUBSTITUTED IMINO-ESTERS

IMIDAZOLE AND TRIAZOLE SUBSTITUTED OXIME ETHERS

PROCEDE DE PREPARATION DE DERIVES DE L'X-UISONITROSO ACETOPHEN ONE

Pestizide Mittel

VERFAHREN ZUM VERNETZEN VON POLYMERISATEN, DIE MERCAPTANGRUPPEN ENTHALTEN UND VERNETZBARE ZUSAMMENSETZUNGEN ZUR DURCHFUEHRUNG DES VERFAHRENS.

SCHAEDLINGSBEKAEMPFUNGSMITTEL.

Verfahren zur Herstellung von Hydroxamoylchloriden

Process for the preparation of a syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7beta-acylamidocephem-4-carboxylic acids

MEANS TO THE PROTECTION OF PLANT CULTURES.

Compositions on the basis of oxime ethers, oxime esters or oxime carbamates which are suitable in agriculture for crop protection

PROCEDURE FOR THE PRODUCTION OF A NIEDERALKYL-2-CHLOR-2-HYDROXYIMINOACETATS.

METHOD OF INCREASING EXPRESSION OF MOLECULAR CHAPERONS USING HYDROXYLAMINE DERIVATIVES, DRUG FORMULATIONS (VARIANTS)

COMPOSITIONS BIOCIDES

COMPOSED OF 1-CARBAMOIL-N-CARBAMOILOXIFORMIMIDATOS USEFUL LIKE PESTICIDES, COMPOSITIONS CONTAIN THAT THEM, METHODS FOR ITS ELABORATION AND COMPOSED INTERMEDIARY EQUIPMENT IN THIS PROCEDURE

DERIVES D'OXIMES POUR LA PROTECTION DES CULTURES

Способ борьбы с нежелательной растительностью

Diphenyl ether cyclic imine derivatives having the general formula I: <CHEM> wherein R1 represents a halogen atom or a haloalkyl group; R2 and R3, which may be the same or different. each independently represents a hydrogen or halogen atom or a nitro, cyano or haloalkyl group; A represents a cyano, alkyl, aryl, alkoxy, aryloxy, alkylthio or arylthio or their S-oxygenated derivatives, acyl, acyloxy or alkoxycarbonyl group; and B represents a hydrogen atom or one of the meanings given for A. The preparation of such compounds; compositions containing them; and their use as herbicides.

N-SUBSTITUIERTE IMINOESTER, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG IN SCHAEDLINGSBEKAEMPFUNGSMITTELN

HYDROXYLAMIN DERIVATE VERWENDBAR FÜR DIE VERBESSERUNG DER ERZEUGUNG VON MOLEKULAREN KAPPEN UND DEREN HERSTELLUNG

PRODUCTION OF AROMATIC HYDROXAMIC ACID HALIDES

... 1360407 Hydroxamic acid halides; isocyanates IMPERIAL CHEMICAL INDUSTRIES Ltd 7 Nov 1972 [8 Nov 1971] 51716/71 Heading C2C Aromatic hydroxamic acid halides are prepared by reacting a nitrosyl halide with an aromatic compound containing one or more halomethyl groups attached to an aromatic ring. Aromatic isocyanates may be prepared by the dehydrohalogenation of an aromatic hydroxamic acid halide produced by the above process.

PREPARATION OF BETA-LACTAMIC ANTIBIOTICS

... 1392658 Penicillins; cephalosporins; nitriloxides ALFA FARMACEUTICI SpA 15 May 1973 [15 May 1972] 22750/72 Heading C2C A process of preparing an isoxazolylpenicillin of Formula I or an isoxazolylcephalosporin of Formula II or a salt or ester thereof, comprises reacting a nitriloxide of Formula III with 6 - acetoacetamidopenicillanic acid or a 7-acetoacetamidocephalosporanic acid or a salt or ester thereof, wherein X1 and X2 are hydrogen or halogen, and Y is hydrogen, hydroxy, C 1 to C 6 acyloxy or a quaternary ammonium group, and if appropriate, salifying or esterifying the product of the reaction. The acetoacetamido starting materials are prepared by reacting the corresponding amino compound with diketene in aqueous or aqueous-acetonic solution at pH 7 to 8À5. The cephalosporin intermediates are novel and have the Formula V wherein Y has the above meaning. A typical cephalosporin of Formula I is 7-[3-(2-chloro-6- fluorophenyl) - 5 - methyl - 4 - isoxazolylamido] - 3 - ...

Method for preparing hydroxamoyl chlorides

... 1,148,360. Method of preparing hydroxamoyl chlorides. E. I. DU PONT DE NEMOURS & CO. 13 Dec., 1967 [16 Dec., 1966], No. 56713/67. Heading C2C. Hydroxamoyl chlorides of general formula where R is methyl, ethyl or methoxymethyl, are prepared by direct chlorination of an aqueous solution containing 1 to 13% by weight of the corresponding aldoxime at a temperature between 25‹ and - 15‹ C.

Procedure for the production of new Oximcarbamatem

INSEKTIZIDES, AKARIZIDES UND NEMATIZIDES MITTEL

VERFAHREN ZUR HERSTELLUNG VON ISOXAZOLYL-BETA-LACTAM-ANTIBIOTIKA

MITTEL ZUM SCHUTZ VON KULTURPFLANZEN VOR AGGRESSIVEN HERBIZIDEN

PHENYLALKYLCARBONSÄURE DERIVATIVES

Carboxamidine derivatives and their use in the treatment of vascular diseases

ISOCYANATES

Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides

ISOXAZOLYL PENICILLINS AND ISOXAZOLYL CEPHALOSOPORINS AND THEIR DERIVATIVES

COMPOSITIONS, WHICH PROMOTE PLANT GROWTH AND PROTECT PLANTS, BASED ON OXIME ETHERS AND OXIME ESTERS

SUBSTITUTED ALKANYL-AZOLYL OXIME-CARBAMATES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES, ACARICIDES AND NEMATOCIDES

SUBSTITUTED PHENOXYMETHYLPHENYL DERIVATES, THEIR PREPARATION AND THEIR USE FOR CONTROLLING PESTS AND FUNGI

Substituted phenoxymethylphenyl derivatives I X is =CH-OCH3, =CH-CH3 or =N-OCH3; R1 is C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl, C1-C6-haloalkyl, C3-C6-haloalkenyl, C1-C4-alkoxy-C1-C6--alkyl, cyano-C1-C6-alkyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl, an unsubst. or subst. C3-C6-cycloalkyl or C3-C6-cycloalkyl-C1-C4-alkyl group, an unsubst. or subst. aryl-C1-C6-alkyl, aryl-C3-C6-alkenyl or aryloxy-C1-C6-alkyl group, an unsubst. or subst. heterocyclyl or heterocyclyl-C1-C4-alkyl or heteroaryl-C1-C6-alkyl group; R2 and R3 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C2-haloalkyl, C1-C4-alkoxy, C1-C2-haloalkoxy,or, if R2 and R3 are adjacent, together are an unsubst. or subst. oxymethylidenoxy or oxyethylidenoxy bridge; R4 is CN, Cl, Br, C1-C6-alkoxy, C1-C6-alkylthio, C1-C4-haloalkoxy, C1-C4-alkoxy-C1-C4-alkoxy, C3-C6-cycloalkyl-C1-C2-alkoxy, C1-C6-alkylamino,di-(C1-C6-alkyl)amino, C3-C6-alkenyloxy, C3-C6-alkynyloxy, unsubst. or subst. aryloxy or arylthio; R5 is 2 NO2, CN, halogen, C1-C4-alkyl, ...

FUNGICIDES

... 2107084 9218487 PCTABS00016 Compounds having formula (I), wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy or cyano; and one of R1 and R2 is methyl and the other is pyridyl or pyrimidinyl substituted by one or more substituents independently selected from halogen, hydroxy, C1-6 alkyl (itself optionally substituted by C1-6 alkoxy), C1-6 haloalkyl, C1-6 alkoxy (optionally substituted by halogen, R3R4N, cyano, R3C(O), R3OC(O), R3R4NC(O), R3SC(O), H2N.NHC(O), R3S(O)m wherein m is 0, 1 or 2, C3-6 cycloalkyl ¢itself optionally substituted by C1-4 alkyl! or a 5- or 6-membered heterocyclic ring containing one or two oxygen atoms, optionally being in the form of a lactone, the heterocyclic ring being optionally fused to a benzene ring and optionally substituted by C1-4 alkyl), R3S(O)n wherein n is 0, 1 or 2, C2-6 alkenyl, C2-6 alkynyl, C2-6 alkenyloxy, C2-6 alkynyloxy, nitro, cyano, CO2R3, NR3R4, NR3R4C(O), NR3R4C(S), R3R4C:NO, C3-6 cycloalkyl, C3 ...

PRODUCTION OF ALPHA-CHLORO-ALPHA-OXIMINO-4-HYDROXYACETOPHENONE

ABSTRACT .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone is prepared by reacting 4-hydroxyacetophenone with an alkyl nitrite and hydrogen chloride wherein the amount of hydrogen chloride is carefully controlled to limit the amount thereof to about 0.1 to 6 moles of hydrogen chloride per mole of 4-hydroxyacetophenone until at least one equivalent of the alkyl nitrite is reacted. Subsequent to the reaction of the one equivalent of alkyl nitrite, at least 1 mole of hydrogen chloride per mole of initially charged 4-hydroxyacetophenone is added to the reaction medium.

PROCESS FOR PREPARING O-(3-AMINO-2-HYDROXY-PROPYL)-HYDROXYMIC ACID HALIDES

The present invention relates to a novel process for preparing O-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides of formula (I) by reacting a carboxamide oxime of formula (II) wherein R1 is as specified above with reactive 3-amino-2-hydroxy-propane derivative, diazotizing the O-substituted carboxamide oxime thus obtained with sodium nitrite in the presence of hydrogen halide, decomposing the diazonium salt and if desired, separating the optically active enantiomers and/or reacting the resulting base with an organic or mineral acid, wherein the carboxamide oxime of formula (II) is reacted with a 3-hydroxy azetidinium salt of formula (III) wherein R2 and R3 are as defined above and Y- is a salt forming anion, in a lower alcoholic, preferably ethanolic medium optionally containing water and made alkaline with an alkali hydroxide, and before diazotizing the O-substituted carboxamide oxime intermediate obtained, the reaction mixture is neutralised and the organic solvent is removed. The process ...

Process for preparing O-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides

Substituted phenoxymethylphenyl derivatives, their preparation and their use for controlling pests and fungi

Process for the production of lower alkyl 2-chloro-2-hydroxyiminoacetates

Omega-isonitrosoacetophenone bromo derivs - prepd from corresp chloro cpds and used in germicide and bactericide compns

DERIVED From OXIMES FOR the CROP PROTECTION

PROCESS FOR CROSSLINKING POLYMERS CONTAINING MERCAPTAN GROUPS

METHOD FOR PREPARING HYDROXAMOYL CHLORIDES

NEW DERIVATIVES OF 6 TO-THE AMIDINO PENICILLANIC ACID PREPARATION METHOD AND APPLICATIONS THEREOF AS ANTIBIOTICS

BIS (HALOXIMINO) ACETONE AND METHOD OF PREPARATION

ПРОИЗВОДНЫЕ ФЕНИЛАЛКИЛКАРБОНОВОЙ КИСЛОТЫ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of phenylalkylcarboxylic acid of the formula (I) where R 1 means alkyl-group with linear or branched chain having from 1 to 6 carbon atoms; R 21 is alkylene group with linear or branched chain having from 2 to 6 carbon atoms; R 3 is hydrogen atom; Z is alkylene group with linear or branched chain having from 1 to 6 carbon atoms; W means: (i) alkyl-group with linear or branched chain having from 1 to 6 carbon atom; (ii) alkoxy- group with linear or branched chain having from 1 to 4 carbon atoms; (iii) alkylthio-group with linear or branched chain having from 1 to 4 carbon atoms; (iv) amino-group; (v) mono- alkylamino-group with linear or branched chain having from 1 to 4 carbon atoms; (vi) dialkylamino-group with linear or branched chain where alkyl-groups are similar or distinct and each group has from 1 to 4 carbon atoms; (vii) N-alkyl-N-aryl- amino-group having alkyl with linear or branched chain having from 1 to 4 carbon atoms and aryl moiety having from 6 to 10 carbon atoms; (viii) arylhydroxy-group having from 6 to 10 carbon atoms that can has one substituent α indicated below, in aryl moiety; (ix) arylthio-group having from 6 to 10 carbon atoms; (x) arylamino-group having from 6 to 10 carbon atoms; (xi) aralkyl-group having from 7 to 12 carbon atoms or (xii) 1-pyrrolyl group; X means aryl-group having from 6 to 10 carbon atoms that can has one substituent α indicated below being substituent α means: (i) alkyl-group with linear or branched chain having from 1 to 6 carbon atoms; (ii) halogenated alkyl- group with linear or branched chain having from 1 to 4 carbon atoms; (iii) halogen atom; (iv) aryl-group having from 6 to 10 carbon atoms and aryl moiety can be substituted with alkoxy- group with linear or branched chain having from 1 to 4 carbon atoms or halogen atom; or (v) pyridyl; Y means oxygen atom, their pharmacologically acceptable salts of pharmacologically acceptable ...

ПРОИЗВОДНЫЕ КАРБОКСАМИДИНА И ИХ ИСПОЛЬЗОВАНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ СОСУДОВ

... 1. Применение соединений, описываемых общими формулами (I), (II) и (III), где R1 и R2, независимо друг от друга, представляют собой атом водорода или С1-6-алкильную группу с прямой или разветвленной цепью, необязательно замещенную фенильной группой, или R1 и R2, вместе с атомом азота, присоединенным к ним, образуют 5-7-членное насыщенное гетероциклическое кольцо, необязательно содержащее дополнительные гетероатомы азота и/или кислорода, при этом гетероциклическое кольцо необязательно замещено одной или несколькими гидрокси-, оксо- или бензильными группами, А представляет собой фенильную группу, необязательно замещенную одной или несколькими С1-4-алкильными, С1-4-галогеналкильными или нитрогруппами, или атомами галогена, или 5-6-членное гетероароматическое кольцо, содержащее один или несколько гетероатомов, выбранных из азота, кислорода или серы, необязательно имеющее N-оксидную структуру на атоме азота, n равен нулю, 1 или 2, z равен нулю или 1, в соединениях, описываемых общей формулой ...

Биоцид

Oxime carbamates and their use as insecticides, akaricides and nematicides

FLUORINIERTE ALKOXIMINE, DEREN N-CHLOR-UND N-BROM DERIVATE SOWIE VERFAHREN ZUR HERSTELLUNG DAVON.

Improvements in or relating to Cross-Linking Agents and their use in Cross-Linking Unsaturated Polymers

... 1,169,988. Coating. HERCULES Inc. 3 Oct., 1967 [4 Oct., 1966 (2)], No. 45055/67. Headings B2E and B2K. [Also in Divisions C2 and C3] Protective and decorative coatings for various substrates, e.g. wood, metals, paper and plastics, comprise polymers cross-linked with polyfunctional nitrile oxides of the formula O--N # C-CO-CO-C#N+-O-, R-(CO-C=N+-O-) n or R-O-CO-C# N+-O-) n' wherein n is an integer greater than 1 and R is an inert organic radical. Specified polymers are polybutadiene-1,2; polybutadiene- 1,4; styrene-butadiene copolymers; butyl rubber (polyisobutylene-isoprene copolymers); natural rubber; polyester resins; butadieneacrylonitrile copolymers; ethylene-propylenedicyclopentadiene terpolymers; polychloroprene; polyisoprene; alkyd resins; polyether copolymers and terpolymers containing at least one unsaturated epoxide constituent such as propylene oxide-allyl glycidyl ether copolymers and ethylene oxide-epichloro-hydrin-allyl ...

Oxime derivatives for the protection of cultivated crops

There is described a process for the protection of cultivated plants against harmful agricultural chemicals, which process comprises the use of oxime derivatives of the formula (wherein the substituents R1, X and Q are as defined in the text) as antidotes. The cultivated area or the cultivated plants themselves, or parts of the plants (seed, tubers, sections of stalk, etc.), can be treated with these oxime derivatives.

OXIME DERIVATIVES FOR THE PROTECTION OF CULTIVATED CROPS

NEW PENICILLANIC ACID DERIVATIVES

... 1293590 Amidino-penicillanic acids LOVENS KEMISKE FABRIK PRODUKTIONSAK TIESELSKAB 10 Nov 1970 [11 Nov 1969 8 July 1970] 55209/69 and 33211/70 Headings C2A and C2C Novel amidino-penicillanic acid derivatives of Formula I: and salts thereof, wherein R1 and R2 each represent an aliphatic hydrocarbon radical, a mono- or bi-cyclic aryl radical, a cycloalkyl radical, a cycloalkyl-alkyl radical, a heterocyclic radical or a heterocyclically substituted alkyl radical, which radicals may be substituted, e.g. by one or more halogen atoms or alkyl, hydroxy, alkoxy, alkylthio, acyl, carboxy, carbalkoxy, carbamyl, carbamido, cyano, sulphonyl, amino or substituted amino radicals, or R1 and R2 together with the common nitrogen atom form a ring system, and R3 is hydroxyl or substituted hydroxyl, are prepared by either (a) reacting a reactive derivative of an amide or thioamide of formula where R5 is oxygen or sulphur, with a 6-aminopenicillanic acid ...

PROCEDURE FOR THE PRODUCTION OF ISOXAZOLYL BETA LACTAM ANTIBIOTICS

HYDROXYLAMIN OF DERIVATIVES USABLE FOR THE IMPROVEMENT OF THE PRODUCTION OF MOLECULAR CAPS AND THEIR PRODUCTION

SUBSTITUTED 2-PHENYL-3-METHOCYPROPENSÄURENESTER AS FUNGICIDES MEANS.

VERFAHREN ZUR HERSTELLUNG VON NEUEN CEPHALOSPORINEN UND PENICILLINEN

NOVEL O-(3-AMINO-2-HYDROXYPROPYL)-HYDROXIMIC ACID HALIDES AND PROCESS FOR PREPARING THE SAME

PREPARATION OF AROMATIC CARBONYL HYDROXAMOYL CHLORIDES

PREPARATION OF AROMATIC CARBONYL HYDROXAMOYL CHLORIDES

HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULARCHAPERON PRODUCTION AND THE PREPARATION THEREOF

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

1-CARBAMOYL-N-HYDROXY-AND 1-CARBAMOYL-N-CARBAMOYLOXY-FORMIMIDATES

PROCESS FOR CROSSLINKING POLYMERS CONTAINING MERCAPTAN GROUPS

6-(methyleneamino)-penicillanic acid derivs

AGENTS SUPPORTING the GROWTH OF the PLANTS AND PHYTOPROTECTEURS CONTAINING OXIMETHERS AND OXIMESTERS

PREPARATION OF BETA-LACTAMIC ANTIBIOTICS

0-(3-Amino-2-Hidroksi-Propil)-hidroksimik asit halidler hazırlama prosesi.

HYDROXIMIC ACID HALOGENIDES, METHOD FOR THE PRODUCTION AND USE THEREOF

The invention relates to hydroximic acid halogenides of the formula (I) wherein the substituents have the following significance; X - NOCH3, CHOCH3 or CHCH3; Y - O or NH; R1 - halogen; R2 - optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or aryl; R3 - optionally substituted alkyl, alkoxyalkyl, cycloalkyl-alkyl, alkenyl and alkynyl and their salts. The invention also relates to a method for the production and use of said hydroximic acid halogenides.

METHODS OF COMBATTING FUNGI AND BACTERIA USING SUBSTITUTED-ALPHA ISONITROSI-ACETOPHENONES

Novel biocide compositions having as the active compound an acetophenone of the formula WHEREIN R is hydrogen, hydroxy and methyl and a method of killing bacteria and fungi.

FLUOROPICOLINOYL FLUORIDES AND PROCESSES FOR THEIR PREPARATION

Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides. 2. The process of claim 1 , wherein m is 0.3. The process of claim 1 , wherein n is 2 or 3.5. The process of claim 4 , wherein n is 2.7. The process of claim 1 , wherein fluorinating a compound of Formula A is performed in the presence of a catalyst claim 1 , wherein the catalyst is selected from the group consisting of a crown ether claim 1 , a phosphonium halide claim 1 , a polyether claim 1 , a phosphazenium salt claim 1 , and a tetra-substituted ammonium halide.8. The process of claim 7 , wherein the catalyst is a crown ether.9. The process of claim 8 , wherein the crown ether is 18-crown-6.10. The process of claim 1 , wherein the source of fluoride ion is a metal fluoride.11. The process of claim 10 , wherein the metal fluoride is selected from the group consisting of sodium fluoride claim 10 , potassium fluoride and cesium fluoride.12. The process of claim 11 , wherein the metal fluoride is potassium fluoride.13. The process of claim 1 , which includes a solvent claim 1 , wherein the solvent is an alkyl nitrile or an alkyl sulfone.14. The process of claim 13 , wherein the solvent is acetonitrile or sulfolane.16. The process of claim 15 , wherein the solvent is acetonitrile or sulfolane.18. The process of wherein Ris selected from the group consisting of H; alkyl; cycloalkyl; alkenyl; alkynyl; and aryl substituted with from 0 to 5 substituents independently selected from the group consisting of halo claim 17 , C-Calkyl claim 17 , C-Chaloalkyl claim 17 , C-Calkoxy and C-Chaloalkoxy.19. The process of wherein step (b) is performed in the presence of a base.21. The compound of claim 20 , wherein m is 0 and n is 1 claim 20 , 2 claim 20 , 3 or 4.24. The compound of claim 20 , wherein n is 1 or 2. Priority is claimed herein to U.S. Provisional ...

Hydroximic acid derivatives, pharmaceutical preparations in which they are comprised, process of their preparation and intermediates employed in this process

In the present invention there are disclosed hydroximic acid derivatives of the general formula I, in which X represents a halogen, Z represents an optionally substituted phenyl, or an optionally substituted phenyl-alkyl containing 1 or 2 carbon atoms in the alkyl moiety, naphthyl, pyridinyl, picolyl or lutidyl, and R represents alkyl having 1 to 8 carbon atoms or phenyl-alkyl containing 1 or 2 carbon atoms in the alkyl moiety or the group -A-N(Ri1)Ri2, wherein Ri1 and Ri2 represent each hydrogen or alkyl having 1 to 8 carbon atoms or Ri1 and Ri2 together with adjacent nitrogen atom form a five- to seven-membered saturated heterocycle, eventually containing one another hetero atom being selected from a group comprising nitrogen, oxygen, and sulfur, which heterocycle can be optionally substituted with one to four alkyls containing 1 to 8 carbon atoms and A represents a straight or branched alkylene having 1 to 8 carbon atoms, as well as their pharmaceutically acceptable acid addition sa

Fluorescent analysis for quantitative determination of picolinate and other compounds in oxidising agents and oxidising compositions

Изобретение относится к способу обнаружения целевого аналита в образце окисляющей композиции, включающему в себя добавление к указанному образцу эффективного количества восстанавливающего агента, чтобы получить раствор образца и чтобы перкислота восстановилась, анализ указанного раствора образца с детектированием по флуоресценции, где указанная окисляющая композиция включает указанную перкислоту, где указанный восстанавливающий агент нейтрализует указанную перкислоту и где указанный целевой аналит представляет собой флуоресцирующее соединение. Изобретение относится также к способу определения концентрации пиколиновой кислоты в образце окисляющего состава, включающему в себя предварительную обработку указанного образца эффективным количеством хлорида тербия, так что указанная пиколиновая кислота образует комплекс с хлоридом тербия; предварительную обработку указанного образца эффективным количеством восстанавливающего агента, чтобы перкислота восстановилась; испускание электромагнитного излучения из источника возбуждения при длинах волн, которые вызывают флуоресценцию пиколиновой кислоты, присутствующей в химическом составе; детектирование флуоресценции, испускаемой пиколиновой кислотой, с использованием заранее заданной зависимости между испускаемой флуоресценцией и концентрацией пиколиновой кислоты. Изобретение также относится к способу определения концентрации целевого химического соединения в химическом составе на основе перкислот, включающему в себя получение образца указанного состава на основе перкислот путем разбавления указанного состава водой; добавление к указанному образцу эффективного количества восстанавливающего агента, чтобы перкислота восстановилась; воздействие на указанный образец электромагнитным излучением при некоторой длине волны, чтобы вызвать флуоресценцию в целевом соединении, присутствующем в химическом составе; детектирование флуоресценции, испускаемой целевым химическим соединением; и определение концентрации целевого химического ...

Ester derivant of dabigatran and its production and use

本发明属医药技术领域，主要涉及通式I所示的达比加群的酯衍生物及其非毒性药学上可接受的盐，以及含有这些化合物作为活性成分的药物组合物，以及所述化合物及药物组合物作为制备凝血酶抑制剂的用途。

Novel hydroxymic acid derivatives, pharmaceutical compositions comprising the same and methods for preparing the same

Patent JPS6034538B2

Application of micromolecular compound in preparation of anti-tumor metastasis medicine

本发明属于医药技术领域，具体涉及一类小分子化合物在制备抗肿瘤转移药物中的应用。本发明的通过邻甲基苯甲酸出发，制备得到了小分子化合物，小分子化合物影响肿瘤细胞转移时骨架蛋白的重组，对肿瘤细胞转移具有显著的抑制作用。

Synthesis of 2-chloro-2-hydroxyiminoacetic acid alkyl ester

OXIMUM DERIVATIVES FOR THE PROTECTION OF CROPS

Dérivés d'oximes pour la protection des cultures. Les dérivés d'oxime utilisés selon l'invention répondent à la formule : Oxime derivatives for crop protection. The oxime derivatives used according to the invention correspond to the formula:

Triacylated amidoxime derivatives, synthesis thereof and industrial applications thereof especially as crosslinking agents for polyolefins

New triacylated amidoxime derivatives, synthesis thereof and industrial applications thereof, especially as crosslinking agents for polyolefins, in particular of high density polyethylene, are described. These compounds correspond to the general formula: in which R and R<1> are monovalent organic radicals, and R<2> and R<3> are also monovalent organic radicals or form, with each other, an aliphatic, alicyclic or aromatic divalent radical -Z-. They can be prepared by a process which comprises the halogenation of an aldoxime in the hydroxamoyl halide form, which is then acylated and then reacted with an alkaline imide.

Nicotinic acid purification process

Patent FR2389602A1

Procédé de production de 2-chloro-2-hydroxyirninoacétates d'alkyle inférieur et nouveaux produits ainsi obtenus. Les 2-chloro-2-hydroxyiminoacétates d'alkyle inférieur sont produits en faisant réagir du chloral avec un alcanol inférieur et un sel d'hydroxylamine, en présence d'un acide de Lewis ou d'un oxyde métallique transformable en acide de Lewis au cours de la réaction, pour donner un 2-hydroxyiminoacétate d'alkyle inférieur et puis en chlorant le produit obtenu, ou bien en faisant réagir l'oxime de chloral avec un alcanol inférieur en présence d'une base pour donner un 2-hydroxyiminoacétate d'alkyle inférieur et en chlorant finalement le produit ainsi formé. La présente invention est particulièrement utile pour fournir de nouveaux procédés de production de 2-chloro-2-hydroxy-iminoacétates d'alkyle inférieur avec des rendements importants, ces produits etant des intermédiaires pour la synthèse de 1,1-diméthyl-3-(5-t-butyl-3.isoxazolyl) urée et de composés analogues qui sont utiles comme herbicides. Process for the production of lower alkyl 2-chloro-2-hydroxyirninoacetates and novel products thus obtained. Lower alkyl 2-chloro-2-hydroxyiminoacetates are produced by reacting chloral with a lower alkanol and a hydroxylamine salt, in the presence of a Lewis acid or a metal oxide convertible into a Lewis acid in the during the reaction, to give a lower alkyl 2-hydroxyiminoacetate and then chlorinate the product obtained, or else by reacting the chloral oxime with a lower alkanol in the presence of a base to give a 2-hydroxyiminoacetate d lower alkyl and finally chlorinating the product thus formed. The present invention is particularly useful for providing novel processes for the production of lower alkyl 2-chloro-2-hydroxy-iminoacetates in high yields, these products being intermediates for the synthesis of 1,1-dimethyl-3- ( 5-t-butyl-3.isoxazolyl) urea and the like which are useful as herbicides.

Process for the preparation of pyridinecarboxamides with basic substituents

Pyridinecarboxamides with basic substituents correspond to the general formula I <IMAGE> in which R1 is lower alkyl and -OR1 is adjacent to the carboxamide group, R2 is lower alkyl or an ethylene radical which is bonded to the trivalent radical called A and the nitrogen atom located between them to form a 6-membered ring, if R2 is lower alkyl then A is a divalent saturated hydrocarbon radical which includes not more than a single ring with 5 or 6 ring members and which has not more than 7 carbon atoms and whose two bonding points are separated by (3-m) to 4 carbon atoms, or if R2 is an ethylene radical then A is the trivalent 1-propanyl-3-ylidene radical when m is 1 or the trivalent 1,2,4-butanetriyl radical when m is zero, and one of the factors m and n is zero and the other is 1, and the ring B is further substituted if desired, and are prepared by reaction of corresponding pyridine carboxamides which have basic substituents and which have in place of the substituent OR1 a halogen atom with atomic number 17 or above or the hydroxyl group with its metal compounds of lower alkanols or with agents introducing a lower alkyl group and, if desired, subsequent salt formation. The compounds show, in particular, apomorphine- and amphetamine-antagonistic effects and can be used, in particular, as antiemetics, psychosomatics and antipsychotics.

PESTICIDAL COMPOSITIONS AND PROCESS TO OBTAIN THE RESPECTIVE ACTIVE SUBSTANCES AND THEIR INTERMEDIARIES

PHENYLALKYLCARBONSÄURE DERIVATIVES

(2-hydroxy (or alkoxy)imino)acylamido penicillanic and - cephalosporanic acids - useful as antibiotics and intermediates

7 beta-Acylamidoceph-3-em-4-carboxylic acids and 6 beta-acylamidopenam-3-carboxylic acids and their non-toxic derivs., in which the acylamido gp. is of formula: (where R is H or an org. gp. and R1 is H or acyl), the cpd. being the syn isomer or a mixt. contg. >=75% syn isomer, are antibiotics and inters. R is pref. R2, R2(CH2)mQn(CH2)p, Cn1.H2n1+1, Cn11H2n11-1, Cn11H2n11-3 or CN, where R2 is heteroaryl, opt. substd. aryl or cycloalkyl, cycloalkadienyl or a non-aromatic or mesoionic gp.; m is 0-4; n is 0 or 1; n1 is 1-7; n11 is 2-7; p is 1-4; Q is O, S or NR; R1 is H or R3CO, where R3 is a 1-20C (cyclo)aliphatic or aromatic gp. opt. bonded to CO via O, S or NH and opt. substd. by halogen, NH2, NO2, 1-6C alkyl or alkoxy. The cpds. may be prepd. e.g. by reacting the corresp. opt. carboxyl-protected 6-APA or 7-ACA with an acylating agent correspg. to the acid RC(NOR1)COOH or its precursor.

Diphenyl ether cyclic imine derivatives

ABSTRACT Diphenyl ether cyclic immune derivatives having the general formula I: wherein R1 represents a halogen atom or a haloalkyl group; R2 and R3, which may be the same or different, each independently represents a hydrogen or halogen atom or a nitro, cyano or haloalkyl group; A represents a cyano, alkyl, aryl, alkoxy, aryloxy, alkylthio or arylthio or their S-oxygenated derivatives, acyl, acyloxy or alkoxycarbonyl group; and B represents a hydrogen atom or one of the meanings given for A. The preparation of such compounds; compositions containing them; and their use as herbicides.

Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Separation of nicotinamide from its isomers

Ether Herbicides

Ether herbicides

Diphenyl ether cyclic imine derivatives having the general formula I: wherein R, represents a halogen atom or a haloalkyl group; R 2 and R 3 , which may be the same or different. each independently represents a hydrogen or halogen atom or a nitro, cyano or haloalkyl group; A represents a cyano, alkyl, aryl, alkoxy, aryloxy, alkylthio or arylthio or their S-oxygenated derivatives, acyl, acyloxy or alkoxycarbonyl group; and B represents a hydrogen atom or one of the meanings given for A. The preparation of such compounds; compositions containing them; and their use as herbicides.

Pyridylium-s-triazines for regulating plant growth

Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Antibiotics

A process for the preparation of cephalosporin compounds of the formula ** (See formula) ** (in which R is a hydrogen atom or an organic group , R is a hydrogen atom or an acyl group, B is > S or > S → 0, and P is a group -CH2Y, where Y is the remainder of a nucleophile or a derivative of the remainder of a nucleophile) and non-toxic derivatives thereof, which comprises reacting a compound of the formula ** (See formula) ** (in which Acyl is the group (see formula), where R and Ra have the previously defined meanings, or a precursor thereof, B is as defined above, R1 is a hydrogen atom or a carboxyl blocking group, Y 'is a replaceable nucleophilic moiety and the dashed line that bridges positions 2, 3, and 4 indicates that the compound may be a cef-2-em compound or a cef-3-em compound with a nucleophile; after which, if necessary or if desired in each case, any of the following reactions are carried out: (i) conversion of a group precursor <br/> <br/> (see formula) desired in that group mentioned, (ii) conversion of a Δ2 isomer into the Δ isomer; desired, (iii) removal of any carboxyl blocking groups, (iv) reduction of a compound in which B is > S → 0 to form the corresponding compound in which B is > S, (v) reduction of a compound in which Y is azide to form a 3-aminomethyl compound, (vi) reaction of a compound in which Y is azide with a dipolarphil to form a compound having a polyazole ring linked to the methylene group at position 3, (vii) deacylation of a compound in which Y is an acyloxy group to form a 3-hydroxymethyl compound, and (viii) acylation of a compound in which Y is hydroxy to form a 3-acyloxymethyl compound; and, finally, recovering the desired compound of formula (I) or a non-toxic derivative thereof in the form of a non- or anti-isomer or as a mixture of isomers containing at least 75% of one of the isomers. (Machine-translation by Google Translate, not legally binding)

Preparation of c1-c6 alkyl 2-chloro-2-hydroxy-iminoacetates

Patent FR2184851B1

TRIACYCLE DERIVATIVES OF AMIDOXIMES, THEIR SYNTHESIS AND THEIR INDUSTRIAL APPLICATIONS IN PARTICULAR AS CROSSLINKING AGENTS OF POLYOLEFINS

Biocide composition

Methods for detecting a substituted or unsubstituted mono, di or tripicolinic acid target analyte, and for determining picolinic acid concentration

Trata-se de um método para detectar fluorometricamente a concentração de componentes químicos em formulações oxidantes. Em uma modalidade específica, a detecção é do componente estabilizante de ácido picolínico, presente em tais formulações, embora qualquer componente que apresente fluorescência possa ser detectado. De acordo com a invenção, a preparação de amostra da formulação oxidante inclui adicionar à dita amostra um excesso de agente redutor para aglutinar perácido, e no caso de ácido picolínico, adicionar à dita amostra um excesso de cloreto de térbio. A amostra é, então, submetida à radiação para induzir fluorescência e a concentração do dito componente químico é determinado por uma relação linear entre a fluorescência emitida e a concentração do produto químico-alvo. It is a method for fluorometrically detecting the concentration of chemical components in oxidizing formulations. In a specific embodiment, detection is of the picolinic acid stabilizing component present in such formulations, although any component that fluoresces may be detected. In accordance with the invention, sample preparation of the oxidant formulation includes adding to said sample an excess of reducing agent to bind peracid, and in the case of picolinic acid, adding to said sample an excess of terbium chloride. The sample is then subjected to radiation to induce fluorescence and the concentration of said chemical component is determined by a linear relationship between the emitted fluorescence and the concentration of the target chemical.

Patent JPS4961191A

Substituted 8-phenylisoxazolo[4,3-e][1,4]diazepin-5-ones

This invention relates to substituted 8-phenylisoxazolo[4,3-e][1,4]diazepin-5-ones of the formula <IMAGE> wherein R is lower alkyl; R1 is hydrogen, amino alkyl, propargyl and lower alkyl; X is oxygen and sulfur; and Y is halogen, trifluoromethyl, lower alkyl, lower alkoxy and hydrogen. The compounds of this invention display useful anxiolytic and anticonvulsant activites.

1-carbamoyl-n-hydroxy formimidates and 1 - carbamoyl - n-carbamoyloxyformimidates

A CLASS OF 1-CARBAMOYL-N-CARBAMOYLOXY FORMIMIDATES, SUCH AS METHYL 1-(DIMETHYLCARBAMOYL) - N - (METHYLCARBAMOYLOXY)-FORMIMIDATE, USEFUL IN PREVENTING THE DESTRUCTIVE EFFECTS OF PESTS SUCH AS INSECTS, TICKS, MITES AND NEMATODES.

Patent EP0684943A4

A process for the selective chlorination of pyridine, a lower alkyl pyridine or 3-cyanopyridine includes passing the pyridine compound, chlorine and an inert gas through a two stage reaction. In a first reaction zone, these materials are subjected to a hot spot controlled at a temperature of about 350 °C to about 500 °C. The materials are then subsequently passed through a second reaction zone at a relatively lower temperature, for example below about 340 °C.

Plant Growth Regulator

Patent FR2098412A1

Patent FR2211263B1

Cleavage of dialkoxyketoxime

Dialkoxyketoximes such as dimethoxycyclohexanone cleave with halogen and water under basic conditions to yield a series of products having an ester functionality and another functionality which is oximohalide, nitrile oxide or furoxan, depending upon the base strength and/or work-up conditions. Each of those products can be further reacted with sulfur dioxide to produce an adduct, from which an isocyanate is derived. Both the adduct and the isocyanate retain the ester functionality.

Process for chlorinating benzaldehyde oximes

本發明係有關一種製備通式( I )之氯苯甲醛肟的新穎方法。

Process for preparing alpha-chloro-alpha-oximino-4-hydroxyacetophenone

A process for the preparation of α-chloro-α-oximino-4-hydroxyacetophenone by reacting nitrosyl chloride with 4-hydroxyacetophenone is disclosed. The nitrosyl chloride is introduced as a gas into the to contact 4-hydroxyacetophenone dissolved in a solvent therein.

PROCEDURE FOR PREPARING A DERIVATIVE OF (IMINA CICLICA) - DIFENIL-ETER

Isoxazolyl penicillins and cephalosporins isoxazolyl penicillins and cephalosporins

FLUORIZED CARBAMATE INDEXTS

Purification of nicotinamide

Trichloroacryloyl oxime derivatives

Process for preparing o-(3-amino-2-hydroxy-propyl)hydroxymic acid halides

Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same.

La invencion se refiere a derivados de ácido hidroxímicos biologicamente activos de la formula (I): en donde X significa halogeno; Z se refiere a un grupo aromático, grupo piridinilo o similares; y R representa un grupo alquilo o fenilalquilo o un grupo -A-N(R1 y R2), y en la ultima, R1 y R2 se refieren, independientemente uno del otro, a hidrogeno o grupo alquilo; o R1 y R2, junto con el átomo de nitrogeno adyacente, forman un grupo heterocíclico saturado de 5 o 7 miembros, que contienen opcionalmente un átomo de nitrogeno, oxígeno o azufre adicional, dicho grupo heterocíclico siendo substituido opcionalmente por lo menos de un grupo alquilo; y A se refiere aun grupo alquileno de cadena recta o ramificada, así como a sus sales ácidas de adicion farmacéuticamente aceptables; además, la invencion se refiere a un proceso para la preparacion de los compuestos novedosos anteriores y a composiciones farmacéuticas que contienen estos compuestos o sus sales ácidas de adicion farmacéuticamente aceptables como ingredientes activos.

Patent JPS504237A

Process of extracting pyridine carboxylic acids as bisulfates

Chlorination process

A process for the selective chlorination of pyridine, a lower alkyl pyridine or 3-cyanopyridine includes passing the pyridine compound, chlorine and an inert gas through a two stage reaction. In a first reaction zone, these materials are subjected to a hot spot controlled at a temperature of about 350 °C to about 500 °C. The materials are then subsequently passed through a second reaction zone at a relatively lower temperature, for example below about 340 °C.

Fluorescence assay for quantification of picolinate and other compounds in oxidants and oxidizing compositions.

SE DIVULGA UN MÉTODO DE DETECCIÓN FLUOROMÉTRICA DE LA CONCENTRACIÓN DE COMPONENTES QUÍMICOS EN FORMULACIONES OXIDANTES. EN UNA FORMA DE REALIZACIÓN PARTICULAR, LA DETECCIÓN ES DEL COMPONENTE ESTABILIZANTE DE ÁCIDO PICOLÍNICO, PRESENTE EN TALES FORMULACIONES, A PESAR DE QUE SE PUEDE DETECTAR CUALQUIER COMPONENTE QUE ES FLUORESCENTE. DE ACUERDO CON LA INVENCIÓN, LA PREPARACIÓN DE MUESTRAS DE LA FORMULACIÓN OXIDANTE INCLUYE LA ADICIÓN A DICHA MUESTRA DE UN EXCESO DE AGENTE DE REDUCCIÓN PARA UNIRSE CON PERÁCIDO Y EN EL CASO DEL ÁCIDO PICOLÍNICO, ADICIÓN A DICHA MUESTRA DE UN EXCESO DE CLORURO DE TERBIO. LA MUESTRA SE SOMETE LUEGO A RADIACIÓN PARA INDUCIR LA FLUORESCENCIA Y LA CONCENTRACIÓN DE DICHO COMPONENTE QUÍMICO POR UNA RELACIÓN LINEAL ENTRE LA FLUORESCENCIA EMITIDA Y LA CONCENTRACIÓN DEL PRODUCTO QUÍMICO DIANA. A FLUOROMETRIC DETECTION METHOD OF THE CONCENTRATION OF CHEMICAL COMPONENTS IN OXIDIZING FORMULATIONS IS DISCLOSED. IN A PARTICULAR EMBODIMENT, THE DETECTION IS OF THE STABILIZING COMPONENT OF PICOLINIC ACID, PRESENT IN SUCH FORMULATIONS, EVEN THAT ANY COMPONENT THAT IS FLUORESCENT CAN BE DETECTED. IN ACCORDANCE WITH THE INVENTION, THE PREPARATION OF SAMPLES OF THE OXIDIZING FORMULATION INCLUDES THE ADDITION TO SUCH SAMPLE OF A REDUCTION AGENT EXEMPTION TO JOIN PERACCID AND IN THE CASE OF THE PICOLINIC ACID, ADDITION TO SUCH EXCESS OF AN EXCESS CLASS . THE SAMPLE IS SUBMITTED TO RADIATION TO INDUCE FLUORESCENCE AND THE CONCENTRATION OF SUCH CHEMICAL COMPONENT BY A LINEAR RELATIONSHIP BETWEEN FLUORESCENCE ISSUED AND THE CONCENTRATION OF THE DIANA CHEMICAL PRODUCT.

New penicillanic acid derivatives,their preparation and pharmaceutical compositions containing them

Patent SU406362A3

Patent FR2191844A1

Drugs for relieving peripheral circulation disorder

Drug having a vasodilative effect and being efficacious in preventing and treating peripheral circulation disorder. These drugs contain as the active ingredinet 5-amino-N-cyano-N'-[2-(2-chlorophenyl)ethyl]-3-pyridinecarboximidamide or salts thereof and are useful as drugs having, in addition to the above effect, the effects of relieving hyperinsulinemia, impaired glucose tolerance, insulin resistance and visceral fat accumulation.

Polyfunctional carbonyl nitride oxides

This invention relates to polyfunctional carbonylnitrile Noxides and their carbonyl hydroximoyl halide and carbonyl nitrolic acid precursors as new compositions of matter.

Patent JPS518955B1

METHOD FOR RADIOACTIVE CONJUGATION

1. Способ мечения радиоизотопом молекулы, обеспечивающей направленную доставку к биомишени, при котором:(1) берут защищенное соединение Формулы (IA) или (IB)(2) удаляют защиту с защищенного соединения Формулы (IA) или (IB) стадии (1) с получением аминооксисоединения Формулы (IIA) или (IIB) соответственно;(3) осуществляют конденсацию:(а) либо аминооксисоединения Формулы (IIA) с карбонильным соединением Формулы (IIIA)(б) либо аминооксисоединения Формулы (IIB) с карбонильным соединением Формулы (IIIB)с получением меченого радиоизотопом конъюгата Формулы (IVA) или (IVB) соответственно:где [ВТМ] представляет собой молекулу, обеспечивающую направленную доставку к биомишени;Xпредставляет собой защищенную аминооксигруппу формулыгде Rи Rнезависимо выбраны из Салкила, Cфторалкила или Cарила;Q представляет собой группу, которая содержит радиоизотоп, подходящий для in vivo визуализации PET (позитронно-эмиссионной томографии) или SPECT (однофотонной эмиссионной компьютерной томографии);Yпредставляет собой H, Салкил или Сарил,[линкер] представляет собой линкерную группу.2. Способ по п.1, где Rи Rнезависимо представляют собой Салкил.3. Способ по п.1 или п.2, где на стадии (1) используют соединение Формулы (IA), так что аминооксисоединение со стадии (2) имеет Формулу (IIA), и меченный радиоизотопом конъюгат имеет Формулу (IVA).4. Способ по п.1, где Yпредставляет собой H.5. Способ по п.1, где Q выбран изF,I,Tc,Ga илиCu.6. Способ по п.5, где Q представляет собойF.7. Способ по п.1, где ВТМ содержит единственную аминокислоту, 3-100-мерный пептид, субстрат фермента, антагонист фермента, агонист фермента, ингибитор фермента или рецепторсвязующее соединение.8. Способ по п.7, где ВТМ содержит Affibody™.9. Спосо

Nitrile imines

Disclosed are polyfunctional nitrile imines having the formula selected from R-C identical N -N -R'')x and R-N -N identical CR'''')x where R is an alkylene, cycloalkylene, arylene, alkylarylene, arylene-dialkylene, alkylene-diarylene or cycloalkylenedialkylene radical; R'' is a hydrogen, alkyl, cycloalkyl, aryl, alkaryl, or aralkyl radical; R'''' is an alkyl, cycloalkyl, aryl, alkaryl or aralkyl radical and x is greater than 1; and their hydrogen chloride salts having the formula selected from D R A W I N G

ANVAENDNING AV OMEGA-BROM-OMEGA-ISONITROSO-ACETOPHENONDERIVAT SOM BIOCIDER

TRICHLORACRYLOYLOXIM COMPOUNDS, PROCEDURES FOR PREPARING THEREOF AND THEIR USE AS ANTI-FUNGICIDES

Pyridylium-s-triazines for regulating plant growth

2,4-bis-pyridylium-s-triazines of the formula WHEREIN R1 represents hydrogen, lower alkyl, lower haloalkyl, NH2, OH, phenyl, 4-pyridyl, N''-methyl-4''-pyridylium, R2 and R3 each independently represent alkyl, alkenyl, an alkyl radical substituted by halogen, alkoxy, alkylthio, cyano, alkoxycarbonyl, and X represents the anion of an inorganic or organic acid or a trivalent halogen anion, are growth regulating agents which produce increases in yield or quality in crop plants or which facilitate harvesting.

Process for separating beta-pyridyl nitrile and nicotinamide from an aqueous mixturecontaining nicotinic acid

New derivatives of hydrosamic acid, pharmaceutical compositions based on them and method for their preparation

The invention relates to new compounds having the formula where X means halogen, Z is aromatic or pyridinyl group or the like, and R is alkyl or phenylalkyl group, or the group -A-N(R1)R2 where R1 and R2, independent from each other, mean hydrogen or alkyl group or R1 and R2 together with the nitrogen atom to which they are bound form 5- to 7-member saturated heterocylic ring, in a given case additionally containing nitrogen, oxygen or sulphur atom, and this heterocyclic ring in a given case being substituted by at least one alkyl group, and A meaning alkylene group having a straight or branching chain, and to their pharmaceutically acceptable salts, adjunctive to acids. The invention also relates to new intermediate compounds with the formula The compounds with formula I have antiischemic effect and find application for the treatment of, for example, myocardial ischemia, inducted, for example, by coronary artery occlusion. 10 claims

Recovery of nicotinic acid by solvent extraction

3,3'-(2,6-pyridinediyl-5-isoxazole carboxylic acids, salts, and esters, compositions and methods of use thereof

Novel compounds of the formula ##STR1## wherein X is hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro or bromo; R is hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation and novel compositions wherein R is hydrogen or a physiologically acceptable metal or amine cation are used for prophylactically treating allergic disorders such as asthma. BRIEF SUMMARY OF THE INVENTION It has now been discovered that novel compounds of Formula I are useful in the prophylactic treatment of sensitized humans and animals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration. DETAILED DESCRIPTION OF THE INVENTION ##STR2## wherein X is hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro or bromo; R is hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation. Another group of compounds, hereafter referred to as Group B, are those compounds of Group A wherein R is hydrogen, alkyl of one to six carbon atoms, inclusive, or a physiologically acceptable metal or amine cation; X is hydrogen, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro and bromo. A further group of compounds, hereafter referred to as Group C, are those compounds of Group B wherein R is hydrogen, alkyl of one to three carbon atoms, inclusive, or a physiologically acceptable metal or amine cation; X is hydrogen, alkyl of one to three carbon atoms, inclusive, alkoxy of one to three carbon atoms, inclusive, phenyl, cyano, trifluoromethyl, fluoro, chloro or bromo. ...

Nitrile imines

Disclosed are polyfunctional nitrile imines having the formula selected from R----C.tbd.N.sup.⊕ --N.sup.⊖ --R') x and R----N.sup.⊖ --N.sup.⊕ .tbd.C--R") x where R is an alkylene, cycloalkylene, arylene, alkyl-arylene, arylene-dialkylene, alkylene-diarylene or cycloalkylene-dialkylene radical; R' is a hydrogen, alkyl, cycloalkyl, aryl, alkaryl, or aralkyl radical; R" is an alkyl, cycloalkyl, aryl, alkaryl or aralkyl radical and x is greater than 1; and their hydrogen chloride salts having the formula selected from ##STR1## where R, R', R" and x are as defined above.

Process for recovering pyridine carboxylic acids from pyridine carboxylic acid bisulfates

Process for the preparation of o- (3-amino-2-hydroxypropyl) -hydroxy acid halides

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE HALOGENETOS DO áCIDO O-(3-AMINO-2-HIDROXIPROPRIL)-HIDROXìMICO"<D>. A presente invenção refere-se a um novo processo para a preparação de halogenetos do ácido O-(3-amino-2-hidroxipropil)-hidroxímico de fórmula (I) por reação de uma carboxamida oxima da fórmula (II) onde R^ 1^ é como especificado acima com um derivado reativo de 3-amino-2-hidroxipropano, diazotização da carboxamida oxima O-substituída assim obtida com nitrito de sódio na presença de halogeneto de hidrogênio, decomposição do sal de diazónio e, se desejado, separação dos enantiómeros oticamente ativos e/ou reação da base resultante com um ácido orgânico ou mineral, onde a carboxamida oxima da fórmula (II) é reagida com um sal de 3-hidróxi azetidínio de fórmula (III) onde R^ 2^ e R^ 3^ têm o significado mencionado acima e Y^ -^ é um ânion formador de sal, em um meio alcoólico inferior, de preferência etanólico, opcionalmente contendo água e tornado alcalino com um hidróxido alcalino, e antes da diazotização do intermediário carboxamida oxima O-substituída obtido, a mistura reacional é neutralizada e o solvente orgânico é removido. O processo de acordo com a invenção fornece os compostos de fórmula (I) com um rendimento maior comparado com os processos da técnica anterior.

Method for the preparation of new derivatives of penicilanico acid. (Machine-translation by Google Translate, not legally binding)

Method for the preparation of new derivatives of penicillanic acid, of the general formula: **(See formula)** wherein R1 and R2 represent an aliphatic hydrocarbon radical, a mono- or bicyclic aryl radical, an aralkyl radical, a cycloalkyl radical, a cycloalkyl-alkyl radical, a heterocyclic radical or a heterocyclicly substituted alkyl radical; R1 and R2 taken together with the nitrogen atom represent a ring system; and R3 represents a hydroxyl group, or a substituted hydroxyl group; and pharmaceutically acceptable salts thereof, comprising reacting a reactive derivative of an amide or a thioamide of the general formula II: **(See formula)** wherein R1 and R2 have the meanings defined above and R5 represents 0 or S, with a 6-aminopenicilanic acid derivative of the general formula III: **(See formula)** wherein COOR4 is an ester group, or with a silyl ester of 6-aminopenicilanic acid, after which, if desired, the reaction is followed by cleavage of the ester to free acid. (Machine-translation by Google Translate, not legally binding)

PROCEDURE FOR THE PREPARATION OF ISOXAZOLIL-PENICILLINS

Patent FR2164677B1

PROCESS OF MAKING ACID HALIDES O- (3-MINO-2-HYDROXY-PROPIL)-HYDROCSIMATE

Radioconjugation method

The present invention relates to the field of radiopharmaceuticals for

methods for detecting a target analyte, determining picolinic acid concentration and detecting concentration of a target chemical compound.

trata-se de um método para detectar fluorometricamente a concentração de componentes químicos em formulações oxidantes. em uma modalidade específica, a detecção é do componente estabilizante de ácido picolínico, presente em tais formulações, embora qualquer componente que apresente fluorescência possa ser detectado. de acordo com a invenção, a preparação de amostra da formulação oxidante inclui adicionar à dita amostra um excesso de agente redutor para aglutinar perácido, e no caso de ácido picolínico, adicionar à dita amostra um excesso de cloreto de térbio. a amostra é, então, submetida à radiação para induzir fluorescência e a concentração do dito componente químico é determinado por uma relação linear entre a fluorescência emitida e a concentração do produto químico-alvo. It is a method for fluorometrically detecting the concentration of chemical components in oxidizing formulations. in a specific embodiment, detection is for the picolinic acid stabilizing component present in such formulations, although any component showing fluorescence can be detected. According to the invention, the sample preparation of the oxidizing formulation includes adding to said sample an excess of reducing agent for peracid agglutination, and in the case of picolinic acid, adding an excess of terbium chloride to said sample. The sample is then subjected to radiation to induce fluorescence and the concentration of said chemical component is determined by a linear relationship between the emitted fluorescence and the concentration of the target chemical.

Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására

A találmány tárgya javítőtt eljárás (I) általánős képletű O-(3-aminő-2-hidrőxi- prőpil)-hidrőximsav-halőgenidek, ezek savaddíciós sóinak,valamint őptikailag aktív alakjainak előállítására. E képletben R1adőtt esetben helyettesített fenilcsőpőrt, vagy piridil- vagytienilcsőpőrt, X halőgénatőm, R2 és R3 egyenes vagy elágazó láncúalkilcsőpőrt, vagy együttesen, a közrezárt nitrőgénatőmmal 5-7 tagútelített heterőciklűsős csőpőrtőt képeznek, mely adőtt esetben tővábbiheterőatőmőt tartalmazhat, és adőtt esetben szűbsztitűált lehet. Az eljárás sőrán egy (II) általánős képletű karbőxamid-őximőt reaktív3-aminő-2- hidrőxi-prőpán-származékkal reagáltatnak, a kapőtt O-szűbsztitűált karbőxamid-őximőt halőgénhidrőgéansav jelenlétébennátriűm-nitrittel diazőtálják, a diazóniűmsót elbőntják, a kapőttterméket elkülönítik. A találmány lényege, hőgy a (II) általánős képletű karbőxamid-őximőtegy (III) általánős képletű 3-hidrőxi-azetidinűmsóval reagáltatják,ahől R2 és R3 a fenti és Y' sóképző katiőn, alkálihidrőxiddalmeglúgősítőtt, adőtt esetben vizet is tartalmazó rövid szénláncúalkőhőlős, előnyösen etanőlős reakcióelegyben, és a reakció sőránképződő intermedier O-szűbsztitűált karbőxamid-őxim diazőtálása előtta reakcióelegyet semlegesítik, és eltávőlítják belőle a szervesőldószert. ŕ

Hydroximsäurederivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu deren herstellung

Method for chlorinating benzaldehyde oximes

一种3-乙基-吡啶-2-甲脒盐酸盐的合成方法

本发明属于化学合成技术领域，具体涉及一种3‑乙基‑吡啶‑2‑甲脒盐酸盐的合成方法。本发明采用亲核取代，亲电取代，Sandmeyer反应，利用三步反应，从而合成了3‑乙基‑吡啶‑2‑甲脒盐酸盐，该方法简单易操作，提供了一种合成方法。

Verfahren zur chlorierung von benzaldehydoximen

Die vorliegende Erfindung betrifft ein neues Verfahren zur Herstellung von Chlorbenzaldehydoximen der allgemeinen Formel (I).

벤즈알데히드 옥심의 염소화 방법

본 발명은 화학식 (I)의 클로로벤즈알데히드 옥심의 신규 제조 방법에 관한 것이다.

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Method for chlorinating benzaldehyde oximes

The present invention relates to a novel process for preparing chlorobenzaldehyde oximes of the general formula (I).

Processo para a cloração de oximas de benzaldeído

processo para a cloração de oximas de benzaldeído. a presente invenção refere-se a um novo processo para a produção de oximas de cloro-benzaldeído da fórmula geral (i).

苯甲醛肟的氯化方法

本发明涉及一种制备通式(I)的氯苯甲醛肟的新方法。

ベンズアルデヒドオキシムの塩素化方法

本発明は、一般式（I）のクロロベンズアルデヒドオキシムを調製するための新規な方法に関する。

Verfahren zur chlorierung von benzaldehydoximen

Die vorliegende Erfindung betrifft ein neues Verfahren zur Herstellung von Chlor-benzaldehydoximen der allgemeinen Formel (I).