RADIOACTIVE SHIELDING MEMBER FOR RADIOPHARMACEUTICAL SYNTHESIS DEVICE

23-07-2018 дата публикации
Номер:
KR1020180083478A
Принадлежит:
Контакты:
Номер заявки: 00-17-102005606
Дата заявки: 12-01-2017

[1]

Synthesis of radioactive shielding member used in the present invention refers to radioactive pharmaceuticals device are disclosed.

[2]

Radioactive pharmaceuticals administered to a blood sample from a human body or human sample used radioactive isotope and for preparing solid matter such as it is, as well as diagnosis treatment, or medical research over is known in medical field.

[3]

Encapsulated radioactive of drug substance (referred to as "seed material" by) a prostate tumor for solid tumor to radiation by inserting a etc. to kill the tumor cells. In order to reduce restenosis after angioplasty generated using intravascular lumen cells and for exposing the radioactive materials.

[4]

Such treatment as well as the use, in a tracker serves radioactive pharmaceuticals are specific imaging techniques can be used as diagnostic purposes, such imaging techniques using positron emission tomography (Positron Emission Tomography; PET) as an example of a radioactive isotope etc. check is widely used.

[5]

PET can be tested, for example fluorine deoxy glucose (2 - [F provided 18] fluoro-a 2 a-deoxy-a D non-glucose, 18 FDG) subject such as a human body after intravenous radioactive pharmaceuticals (liquid form number) chain, or organ specific organizations displayed made from a radiation Image determining substrate.

[6]

PET inspection of the existing method is such that the flow could not be found or an early stage cancer tumor tissue can be scaled mm found whether cancer as well as transition and recurrence, anticancer effect going treatment time and number administration may be filled.

[7]

Wherein the radioactive pharmaceuticals for diagnosis of a patient undergoing a medical patient-customized account number purchases purchases morning crude number of highly radioactive pharmaceuticals, or number since numerical control machine, automatic synthesis device in the context of a wand a recent nuclear medical radioactive pharmaceuticals based IT batch with the preferred substrate. This domestic and conform to provide vehicle, current GE yarn (American), Siemens yarn (Germany), IBA yarn (belgium), global medical devices for diagnosing radioactive pharmaceuticals such as PET firms philips yarn automatically synthesizing an automatic synthesis device etc. develop positive number. In particular, tumor in a nuclear medical diagnostic system for supporting its radioactive pharmaceuticals [18 F] FDG (FluoroDeoxyGlucose) automated commercial or research purposes is stabilized following etc. are used. The automatic synthesis device memory for said radioactive pharmaceuticals are various tip function, complex techniques have been mounted, purity and yield synthesis of radioactive pharmaceuticals calculating radiation detection device is necessarily contained the nanometer range.

[8]

In radioactive pharmaceuticals synthesis device of the existing method while a sealed space required by small number of radioactive detection semiconductor tube portion of the PIN diode or CdZnTe radioactive tube off and by attaching several manner, the radioactive detection semiconductor output is fitted to preamplifier and an amplifier that has an RF request charge high noise to be inserted into an electromagnetic wave noise by number and wetting ability, and the good sensitivity not only visually of radioactivity are provided which used for increased information visualization.

[9]

등록특허공보 제10-1283345호(공고일자: 2013.07.09)

[10]

The present invention refers to such known door numbers number point is, together with the synthesis of radioactive pharmaceuticals device each provide radioactive shielding radioactive shielding member number of synthesis can be launching accurate detection of radiation are disclosed.

[11]

To achieve this object the present invention according to synthesis device for radioactive pharmaceuticals for radioactive shielding member, for shielding radioactive pharmaceuticals for synthesizing high pressure liquid coolant device number as the spinnability device, containing the radiation detector inside container is formed, said branched off from a container to a plurality of pin holes or rough surfaces formed on the outer surface of the second conductive layer is formed in a lattice form comprising a shield from radiation shielding.

[12]

Preferably, said shield can be practically and block, said pin hall in addition said container extending in straight form.

[13]

The present invention according to radioactive pharmaceuticals synthesis device for radioactive shielding member, containing the radiation detector is formed inside the container, the container includes a second branch in said measuring position of a plurality of pin holes or rough surfaces that are formed in the form of a radiation shield configured as a block, synthesis device in each stage radiation measuring the amount of radioactive compounds yield can be obtained, in addition to predict yield of final radioactive pharmaceuticals is easily ascertained in previous door number is set and can be disclosed.

[14]

Figure 1 shows a radioactive shielding member according to an embodiment of the present invention also of, Figure 2 shows a configuration of in the embodiment according to of the present invention also other radioactive shielding member, Figure 3 shows a device of the present invention also radioactive pharmaceuticals synthesis of radioactive shield member is provided, Figure 4 shows a shield member is provided in a radiation detector of the present invention also radioactive pharmaceuticals synthesis device detected by means of a radioactive signal ripple example surface.

[15]

Number of the present invention in the embodiment of the present invention general outline according to in the embodiment in which when a specific structure functional disclosure that only to account for the purpose of example, embodiment of the present invention general outline according to in the embodiment are can be in various forms. In addition described in the embodiment are not limited to in the specification and interpreted, idea and techniques of the present invention all changing range of water, including the water to replacement should understood to evenly.

[16]

Hereinafter, with reference to a drawing of the present invention in the embodiment to which detailed illustrating the substrate.

[17]

Figure 1 shows a configuration of radioactive shielding member according to an embodiment of the present invention also are disclosed.

[18]

With reference to the 1 also, in the embodiment according to the radioactive shielding member, containing the radiation detector inside container (110) is formed, the container (110) formed on the outer surface to a radiation in a plurality of pinhole (111) (112) is formed in a lattice form radiation shielding includes an enclosure (100) having a predetermined wavelength.

[19]

Shield (100) includes a lead or tungsten material removably block form is ball number, is container market public affairs therein (110) radiation detector is formed containing the substrate.

[20]

Container (110) using ionizing radiation detector comprises a gas charged to preamplifiers (geiger provided muller counter) anode, anode, or NaI (TI) but not the limited to the anode.

[21]

Pinhole (111) (112) the up-hole (110) in a radiation shield (100) includes a second extending straight to the outer surface of the formed, the number and arrangement and pin hall determined by measuring direction, in the embodiment the in shield (100) disposed on the upper surface of 4 goettfert show of 2000.

[22]

Radioactive pharmaceuticals synthesis device for measuring radiation through isotope emits radiation at position measured by the standard material by each pinhole method of measurement of radioactivity concentration in terms of a sample using standard assay curve.

[23]

Specifically radioactive pharmaceuticals synthesis device is chemical synthesis step so that each radiation isotope method and composite are made and, at each step in the assessment of the digital camera and the reaction in terms of measuring radiation. The radiation detector comprises a shield (100) radiation through the classified each pinhole is a holder received in the background radiation shield (100) shielded by the combustion chamber. The desired step-by-step according as the areas at which the radiation can be achieved by each stage of TMAC synthesis yield more accurate.

[24]

Figure 2 shows a radioactive shielding member as in the embodiment according to of the present invention also other of, in the embodiment according to the radioactive shielding member (200) is, tubular radiation detector case with container (210) and, the container (210) so as to be penetrated lines branched off from a plurality of pinhole (211) (212) is formed in the form of shield radiation shielding is reduced at a hexahedral block (200) which, wherein the pinhole (211) (212) can be disposed along the hole location.

[25]

Figure 3 shows a device of the present invention also as radioactive pharmaceuticals synthesis of radioactive shield member is provided, shield (100) of container (110) radiation detector (10) is accommodated in a, each radioactive pharmaceuticals diastereocontrolled synthesis of each reaction section (21) (22) (23) (24) (25) corresponding to shield (100) includes a container (110) includes a linear communicates with a pinhole (111) (112) (113) (114) (115) formed therein.

[26]

Radiation detector (10) includes a shield (100) installed in a radiation dose delivered detected outputting display unit (120) to connected thereto. Such as shown in Figure 4, a radiation detector comprises a detection of radioactivity in each stage of the synthesis device which, is is chosen to detect two two issues is outputted.

[27]

Each reaction unit (21) (22) (23) (24) (25) in the synthesis of radioactive pharmaceuticals made through each pinhole radioactive generated at each step in the (111) (112) (114) (115) (113) through radiation detector (10) made of radiation detected in each synthesis visualization and accurate radioactive compounds yield control unit can be obtained.

[28]

In addition each step a standard shield (100) through one radiation detector in each pinhole background of radioactivity by that are in the database by the number of miniaturizing the device measuring of radioactivity guide pin is small.

[29]

The present invention refers to the aforementioned in the embodiment and attached drawing than limited by not, within a range that the technical idea of the present invention from a heavy various substituted, it is apparent that the present invention belongs to vertical deformation and change in the art person with skill in the art will.

[30]

100: Shield 110: Container 111, 112, 113, 114, 115: Pinhole



[1]

The present invention provides a radioactive shielding member capable of shielding a background radioactivity and accurately detecting a radioactivity of each synthesis step in a synthesis device of radiopharmaceutical. The radioactive shielding member used in the synthesis device of the radiopharmaceutical comprises a shielding body (100) of a block shape forming a receiving hole (110) in which a radiation detector (10) is received therein, and performing radioactive shielding by forming multiple pin holes (111, 112, 113, 114, 115) branching from the receiving hole (110) and penetrating to an outer side surface.

[2]

COPYRIGHT KIPO 2018

[3]



The spinnability as radioactive pharmaceuticals for synthesizing high pressure liquid coolant device for shielding a device number, containing the radiation detector inside container is formed, said branched off from a container to a plurality of pin holes or rough surfaces formed on the outer surface of the second conductive layer is formed in a lattice form including radioactive pharmaceuticals synthesis device for radioactive shielding member a shield from radiation shielding.

According to Claim 1, characterized in that said shield can be practically block the radioactive pharmaceuticals synthesis device for radioactive shielding member.

According to Claim 1, characterized in that said lines in said container extending pin hall radioactive pharmaceuticals synthesis device for radioactive shielding member.