Determining stereoisomeric excess, concentration and absolute configuration

26-01-2021 дата публикации
Номер:
US0010900941B2
Принадлежит: Georgetown University, UNIV GEORGETOWN
Контакты:
Номер заявки: 15-42-1600
Дата заявки: 08-06-2018







Цитирование НПИ

Aikawa & Mikami, “Asymmetric Catalysis Based on Tropos Ligands,” Chem. Commun. 48:11050-69 (2012).
Bentley et al., “Chirality Sensing of Amines, Diamines, Amino Acids, Amino Alcohols, and Alpha-Hydroxy Acids with a Single Probe,” J. Am. Chem. Soc. 135:18052-55 (2013).
Bull et al., “Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly,” Acc. Chem. Res. 46(2):312-26 (2013).
Gajewy et al., “Asymmetric Hydrosilylation of Ketones Catalyzed by Complexes Formed from Trans-Diaminocyclohexane-Based Diamines and Diethylzinc,” Monatsh Chem. 143:1045-54 (2012).
Gajewy et al., “Mechanism and Enantioselectivity of [Zinc(diamine)(diol)]-Catalyzed Asymmetric Hydrosilylation of Ketones: DFT, NMR and ECD Studies,” Eur. J. Org. Chem. 2013(2):307-18 (2013).
Ghosn & Wolf, “Chiral Amplification with a Stereodynamic Triaryl Probe: Assignment of the Absolute Configuration and Enantiomeric Excess of Amino Alcohols,” J. Am. Chem. Soc.131:16360-61 (2009).
Iwaniuk & Wolf, “Chiroptical Sensing of Citronellal: Systematic Development of a Stereodynamic Probe Using the concept of Isostericity,” Chem. Commun. 48:11226-28 (2012).
Iwaniuk et al., “Enantioselective Sensing of Chiral Amino Alcohols with a Stereodynamic Arylacetylene-Based Probe,” Chirality 24:584-89 (2012).
Joyce et al., “Enantio- and Chemoselective Differentiation of Protected Alpha-Amino Acids and Beta-Homoamino Acids with a Single Copper Host,” Chemistry 18(26):8064-69 (2012).
Li et al., “Absolute Configuration for 1,n-Glycols: A Nonempirical Approach to Long-Range Stereochemical Determination,” J. Am. Chem. Soc. 134:9026-29 (2012).
Meca et al., “Racemization Barriers of 1,1'-Binaphthyl and 1,1′-Binapthalene-2,2′-Diol: A DFT Study,” J. Org. Chem. 68:5677-80 (2003).
Mikami & Aikawa, “Dynamic Asymmetric Catalysis by Diphenylphosphinoferrocene (DPPF)-Nickel Complexes Through Control of Axial Chirality by Chiral Diamines,” Org. Lett. 4(1):99-101 (2002).
Mikami et al., “Tropos or Atropos? That Is the Question!,” Synlett 10:1561-78 (2002).
Miyashita et al., “Synthesis of 2,2′-Bis(Diphenylphosphino)-1,1′-Binaphthyl (BINAP), an Atropisomeric Chiral Bis (Triaryl)Phosphine, and Its Use in the Rhodium(I)-Catalyzed Asymmetric Hydrogenation of α-(Acylamino)Acrylic Acids,” J. Am. Chem. Soc. 102:7932-34 (1980).
Nieto et al., “A Facile CD Protocol for Rapid Determination of Enantiomeric Excess and Concentration of Chiral Primary Amines,” Chemistry 16(1):227-32 (2010).
Nieto et al., “Rapid Enantiomeric Excess and Concentration Determination Using Simple Racemic Metal Complexes,” Org. Lett. 10(22):5167-70 (2008).
PCT/US14/29982, International Search Report and Written Opinion (dated Aug. 12, 2014).
U.S. Appl. No. 16/004,206, filed Jun. 8, 2018.
Wolf & Bentley, “Chirality Sensing Using Stereodynamic Probes with Distinct Electronic Circular Dichroism Output,” Chem. Soc. Rev. 42:5408-24 (2013).
You et al., “An Exciton-Coupled Circular Dichroism Protocol for the Determination of Identity, Chirality, and Enantiomeric Excess of Chiral Secondary Alcohols,” J. Am. Chem Soc. 134:7117-25 (2012).
Yu et al., “Simultaneous Determination of Both the Enantiomeric Composition and Concentration of a Chiral Substrate with One Fluorescent Sensor,” J. Am. Chem.Soc. 134(50):20282-85 (2012).
Zhang & Wolf, “Sensing of the Concentration and Enantiomeric Excess of Chiral Compounds with Tropos Ligand Derived Metal Complexes,” Chem. Commun. 49:7010-12 (2013).
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