Modulators of ATP-binding cassette transporters
24-12-2013 дата публикации
Номер:
US8614327B2
Автор: SHETH URVI, FANNING LEV T D, NUMA MEHDI MICHEL DJAMEL, BINCH HAYLEY, HURLEY DENNIS, ZHOU JINGLAN, HADIDA RUAH SARA S, HAZLEWOOD ANNA, SILINA ALINA, VAIRAGOUNDAR RAJENDRAN, VAN GOOR FREDRICK, GROOTENHUIS PETER D J, BOTFIELD MARTYN, FANNING LEV T. D., HADIDA RUAH SARA S., GROOTENHUIS PETER D. J.
Принадлежит: VERTEX PHARMA, VERTEX PHARMACEUTICALS INCORPORATED
Контакты:
Номер заявки: 69-13-20120924
Дата заявки: 30-11-2012
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
CPC - классификация
AA6A61A61PA61P1A61P1/A61P1/1A61P1/10A61P1/16A61P1/18A61P11A61P11/A61P11/0A61P11/00A61P11/02A61P11/06A61P15A61P15/A61P15/0A61P15/08A61P19A61P19/A61P19/0A61P19/08A61P19/1A61P19/10A61P2A61P21A61P21/A61P21/0A61P21/04A61P25A61P25/A61P25/0A61P25/00A61P25/08A61P25/1A61P25/14A61P25/16A61P25/2A61P25/28A61P27A61P27/A61P27/0A61P27/02A61P27/04A61P3A61P3/A61P3/0A61P3/06A61P3/1A61P3/10A61P35A61P35/A61P35/0A61P35/00A61P37A61P37/A61P37/0A61P37/08A61P5A61P5/A61P5/0A61P5/00A61P5/1A61P5/16A61P5/18A61P7A61P7/A61P7/1A61P7/12A61P9A61P9/A61P9/0A61P9/00CC0C07C07CC07C2C07C21C07C215C07C215/C07C215/7C07C215/76C07DC07D2C07D20C07D209C07D209/C07D209/0C07D209/08C07D209/1C07D209/14C07D209/18C07D209/4C07D209/42C07D209/9C07D209/94C07D21C07D213C07D213/C07D213/2C07D213/20C07D213/7C07D213/73C07D215C07D215/C07D215/2C07D215/22C07D215/227C07D215/3C07D215/38C07D215/5C07D215/56C07D217C07D217/C07D217/0C07D217/06C07D22C07D223C07D223/C07D223/1C07D223/16C07D26C07D265C07D265/C07D265/3C07D265/36C07D27C07D279C07D279/C07D279/1C07D279/16C07D3C07D31C07D311C07D311/C07D311/5C07D311/58C07D4C07D40C07D401C07D401/C07D401/1C07D401/12C07D401/14C07D405C07D405/C07D405/1C07D405/12C07D409C07D409/C07D409/1C07D409/12C07D41C07D413C07D413/C07D413/1C07D413/12C07D417C07D417/C07D417/1C07D417/12C07D47C07D471C07D471/C07D471/1C07D471/10IPC - классификация
AA6A61A61KA61K3A61K31A61K31/A61K31/0A61K31/04CC0C07C07DC07D2C07D21C07D215C07D215/C07D215/3C07D215/38Цитирование НПИ
Brown, R.K., et al., "Derivatives of Indole, 6-Amino-3-indoleacetic Acid," JACS, 1955, vol. 77, No. 14, pp. 3839-3842.Dhar, T.G. Murali, et al., "3-Cyanoindole-Based Inhibitors of Inosine Monophosphate Dehydrogenase: Synthesis and Initial Structure-Activity Relationships," Bioorg. Med. Chem. Lett., 2003, vol. 13, No. 20, pp. 3557-3560.
Grohe, Klaus, et al., "Synthese von 1-Amino-4-chinolon-3-carbonsauren," Liebigs Annalen Der Chemie, 1987, vol. 10, pp. 871-879.
Haynes, R.K., et al., "Amine Oxidation and the Chemistry of Quinone Imines. Part I. 3-Meth-oxy-4-t-butylaniline," J. Chem. Soc, Perkins Trans., 1972, vol. 1, pp. 396-408.
Heilbron, Isidor M., et al., "The Intermolecular Condensation of Acetylmethylanthranilic Acid by Means of Phosphorus Pentachioride and the Formation of a Complex isoCyanine Dye," J. Chem. Soc., 1928, pp. 934-941.
Hennequin, Laurent F., et al., "Design and Structure-Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors," J. Med. Chem., 1999, vol. 42, No. 26, pp. 5369-5389.
Hester, J.B., et al., "Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives," J. Med. Chem., 1964, vol. 7, No. 3, pp. 274-279.
Imanishi, T., et al., "Evidene that a Hybrid Molecule of Norfloxacin and Biphenylacetic Acid is a Potent Antagonist at the GABAa Receptor," Neuropharmacology, 1996, vol. 35, No. 9/10, pp. 1271-1277.
International Search Report for PCT/US2005/022768, dated Jul. 10, 2006.
International Search Report for PCT/US2010/059920, dated Jan. 27, 2011.
Irie, Kazuhiro, et al., "Synthesis of 6-Substituted Indolactams by Microbial Conversion," Tetrahedron, 1995, vol. 51, No. 22, pp. 6255-6266.
Ito, Y., et al., "Inhibition of GABAa Receptor Chloride Channel by Quinolones and Norfloxacin-Biphenylacetic Acid Hybrid Compounds," Neuropharmacology, 1996, vol. 35, No. 9/10, pp. 1263-1269.
Kaminsky, Daniel, et al., "Quinolone Antibacterial Agents. Oxolinic Acid and Related Compounds," J. Med. Chem., 1968, vol. 11, No. 1, pp. 160-163.
Kurata, Hitoshi, et al., "A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives," Bioorg. Med. Chem. Lett., 2004, vol. 14, pp. 1183-1186.
Ma, Tonghui, et al., "High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening," J. Biol. Chem., 2002, vol. 277, No. 40, pp. 27235-37241.
Nosova, E.V., et al., "Synthesis of New Fluorinated Derivatives of Quinolinecarboxylic Acids," Chem. of Heter. Compounds, 2002, vol. 38, No. 8, pp. 922-928.
Perez-Guille, B., et al., "Pharmacokinetics of a cephalone (CQ-M-EPCA) in rats after oral, intraduodenal and intravenous administration," International J. of Pharm., 2004, vol. 282, No. 1-2, pp. 87-94.
Showalter, H.D. Hollis, et al., "Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer," J. Org. Chem., 1996, vol. 61, No. 3, pp. 1155-1158.
Srivastava, Sanjay K., et al., "Quinolones: Novel Probes in Antifilarial Chemotheraphy," J. Med. Chem., 2000, vol. 43, No. 11, pp. 2275-2279.
Van Es, T., et al., "1-Alkyl-1,4-dihydro-4-iminoquinoline-3-carboxylic acids: Synthesis, Structure and Properties," S. Afr. J. Chem., 2002, vol. 55, pp. 13-33.
Van Es, Theodorus, et al., "N,1-Dialky1-7-(alkylamino)-4-(alkylimino)-a,4-dihydroquinoline-3-carboxamides and Their 4-Oxo Derivatives: Synthesis and Properties," S. Afr. J. Chem., 2001, vol. 54, pp. 102-117.