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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 6642. Отображено 100.
05-01-2012 дата публикации

PIEZO-CONTROLLED AND-OR PRESSURE RIPPLE COMPENSATING FLUID SEPARATION PUMP

Номер: US20120003104A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

An embodiment discloses a fluid pump for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the fluid pump comprising a reciprocatable piston configured for moving the mobile phase, a pump drive configured for driving the reciprocatable piston, and a control unit configured for controlling the pump drive so that pressure ripples in a pressure profile of the fluid pump are at least partially compensated to thereby bring the pressure profile in accordance with a predefined target characteristic. Another embodiment discloses a fluid pump for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the fluid pump comprising a reciprocatable piston configured for moving the mobile phase, and a pump drive configured for driving the reciprocatable piston using a piezomechanism. 1. A fluid pump for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase , the fluid pump comprising:a reciprocatable piston configured for moving the mobile phase;a pump drive configured for driving the reciprocatable piston;wherein the pump drive comprises a base drive unit and a piezo drive unit, the base drive unit being configured for providing a base drive component for driving the piston, and the piezo drive unit being configured for providing an additional drive component for driving the piston.2. The fluid pump of claim 1 , comprising a control unit configured for controlling the pump drive so that pressure ripples in a pressure profile of the fluid pump are at least partially compensated to thereby bring the pressure profile in accordance with a predefined target characteristic.3. The fluid pump of claim 1 , wherein the pump drive comprises a single piezo drive.4. The fluid pump of claim 1 , wherein the pump drive comprises a plurality of piezo drives cooperating for mutually driving the reciprocatable piston.5. The fluid pump of claim 1 , wherein the base drive ...

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Номер записи: 1
05-01-2012 дата публикации

Polymerase Enhancing Factor (PEF) Extracts PEF Protein Complexes Isolated PEF Proteins and Methods for Purifying and Identifying

Номер: US20120003713A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for identifying compositions with a polymerase enhancing activity, methods for purifying and using these compositions, and specific extracts, proteins, and complexes that function to enhance polymerase activity. As an example, specifically described is nucleotide and amino acid sequence information for a PEF (P45), which was used to produce a recombinant PEF. 1. A non-naturally occurring composition of matter comprising at least one component possessing nucleic acid polymerase enhancing activity selected from the group consisting of: an isolated or purified naturally occurring polymerase enhancing protein obtained from a bacterial , eukaryotic , or Archaeal source; a wholly or partially synthetic protein having the same amino acid sequence as said naturally occurring protein or an analog thereof possessing polymerase enhancing activity; polymerase-enhancing mixtures of one or more of said naturally occurring or wholly or partially synthetic proteins; a polymerase-enhancing protein complex of one or more of said naturally occurring or wholly or partially synthetic proteins; and a polymerase enhancing partially purified cell extract containing one or more of said naturally occurring proteins.295.-. (canceled) This application claims priority to and is a continuation-in-part of U.S. patent application Ser. No. 08/957,709, filed Oct. 24, 1997, which is a continuation-in-part of U.S. patent application Ser. No. 08/822,774, filed Mar. 21, 1997. The entire contents of those applications are specifically incorporated herein by reference and may be relied on to make and use embodiments of the claimed invention.1. Field of the InventionThe invention relates to the fields of nucleic acid polymerases and nucleic acid polymerization reactions.2. IntroductionThe efficiency of a nucleic acid ...

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Номер записи: 2
12-01-2012 дата публикации

Device for displaying a waveform with variable persistence and method of providing the same

Номер: US20120007874A1
Автор: Matthew S. Holcomb
Принадлежит: AGILENT TECHNOLOGIES INC

A device includes a memory storing a persistence bit for each of a plurality of pixels of a display device, the persistence bit having a first value when a corresponding pixel should be illuminated for displaying a persistent image, and having a second value when the corresponding pixel should not be illuminated for the persistent image; a pseudorandom pixel value generator which during each video frame receives a seed value and generates pseudorandom pixel values for the plurality of pixels, each pseudorandom pixel value being not greater than a specified variable persistence value; a frame value generator outputting a frame value for each video frame; and a match detector which, during each video frame, compares the frame value to the pseudorandom pixel values for the plurality of pixels, and for each pixel where the comparison indicates a match, makes the persistence bit for the corresponding pixel have the second value.

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Номер записи: 3
19-01-2012 дата публикации

CALIBRATING AN OPTICAL DOWNCONVERTER

Номер: US20120014691A1
Автор: Nebendahl Bernd
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus calibrates an optical downconverter configured to receive an optical input signal at a signal input and an optical reference signal at a reference input, and to provide at multiple output nodes characterizing signals for characterizing the optical input signal. The downconverter includes receivers having corresponding optical inputs and respectively providing the characterizing signals at the output nodes, and multiple optical signal paths connected between one of the signal and reference inputs and one of the optical inputs. The apparatus includes a signal analyzing unit coupled to the output nodes and configured to receive and analyze the characterizing signals, a first switch for selectively enabling the optical input signal, and a second switch for selectively enabling the reference signal. The signal analyzing unit is configured to derive correction values based on determined signals at the output nodes derived from selectively enabling at least one of the optical input signal and the reference signal, and to correct the characterizing signals with the derived correction values. 1. A method of calibrating an optical downconverter configured to receive an optical input signal at a signal input and an optical reference signal at a reference input , and to provide at a plurality of output nodes a plurality of characterizing signals for characterizing the optical input signal , wherein the downconverter comprises a plurality of receivers , having corresponding optical inputs and respectively providing the plurality of characterizing signals at the plurality of output nodes , and a plurality of optical signal paths , each optical signal path being connected between one of the signal and reference inputs and one of the optical inputs of the plurality of receivers , the method comprising:determining signals at the plurality of output nodes; andderiving from the determined signals a first set of correction values for correcting the plurality of ...

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Номер записи: 4
09-02-2012 дата публикации

FITTING COUPLER FOR PLANAR FLUID CONDUIT

Номер: US20120031820A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fitting coupler is provided configured for coupling a planar fluid conduit and a fluidic device. The fluidic device comprises a cavity, a device conduit, and a mouth where the device conduit opens into the cavity. A contact pressure element is configured for sealingly pressing the planar fluid conduit to the mouth, so that a conduit opening of the planar fluid conduit opens into the mouth. 1. A fitting coupler configured for coupling a planar fluid conduit and a fluidic device , wherein the fluidic device comprises a cavity , a device conduit , and a mouth where the device conduit opens into the cavity , the fitting coupler comprising:a contact pressure element configured for sealingly pressing the planar fluid conduit to the mouth, so that a conduit opening of the planar fluid conduit opens into the mouth.2. The fitting coupler of claim 1 , comprisinga guidance configured for receiving the planar fluid conduit and for guiding the planar fluid conduit into the cavity.3. The fitting coupler of claim 2 , comprising at least one of:the guidance is or comprises at least one of a through-hole;the guidance loosely holds the planar fluid conduit in position;the guidance securely holds the planar fluid conduit in position.4. The fitting coupler of claim 1 , whereinthe contact pressure element comprises an axial force element configured to exert an axial force in an axial direction with respect to the cavity;5. The fitting coupler of claim 4 , comprising at least one of:the axial force element provides a pressing force to sealingly press the planar fluid conduit to the mouth;the axial force element comprises a thread element configured to act together with a device thread element of the fluidic device to exert the axial force;the axial force element is configured to exert the axial force as a spring-biased force.6. The fitting coupler of claim 1 , whereinthe contact pressure element is configured for interacting with the cavity to sealingly press the planar fluid conduit ...

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Номер записи: 5
01-03-2012 дата публикации

Container for Vials

Номер: US20120048762A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A container for holding vials for use with automated analysis devices has a bottom and four sidewalls. The sidewalls extend perpendicularly to the bottom. Two of the sidewalls are oppositely disposed from one another and have corrugations formed by crests and troughs. The corrugations are arranged such that the crests on one sidewall align with the troughs on the opposite sidewall. Each trough has three angularly oriented panels and is sized to receive and support a vial through contact with only two of the three panels. A cover is also provided. The cover has a top and four sidewalls which extend perpendicularly to the top. Two of the top's sidewalls are oppositely disposed from one another and have corrugations which match and align with the corrugations of the container. A skirt is attached to the sidewalls of the cover and forms a perimeter which receives the container. 1. A container for holding a plurality of vials in a plurality of adjacent rows , said container comprising:a bottom for supporting said vials;first and second oppositely disposed sidewalls attached to said bottom and extending perpendicularly thereto, each of said sidewalls having corrugations formed of a plurality of alternating crests and troughs, each of said troughs comprising a first trough panel, a second trough panel and a third trough panel, each of said trough panels extending perpendicularly to said bottom and oriented angularly with respect to one another, each of said troughs being sized to receive and support one of said vials between said first trough panel and said third trough panel, for each of said troughs, said first and third trough panels are arranged on opposite sides of said second trough panel;third and fourth oppositely disposed sidewalls attached to said bottom and extending perpendicularly thereto, said third and fourth sidewalls being in spaced relation to one another and extending between said first and second sidewalls.2. The container according to claim 1 , wherein ...

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Номер записи: 6
01-03-2012 дата публикации

BIOPOLYMER ARRAY READING

Номер: US20120053086A1
Автор: Cattell Herbert F., Troup Charles D.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided. 121-. (canceled)22. A method for processing biopolymer arrays , comprising:(a) reading a different array identifier for each biopolymer array from a tag associated with that biopolymer array;(b) reading at least some of the biopolymer arrays and saving results from each read biopolymer array in a memory linked with the read array identifier for that array;(c) receiving, at a processor, a communication address associated with a query array identifier;(d) searching the saved results for a matched biopolymer array result having the read array identifier matching the query array identifier; and(e) if the matched biopolymer array result is found, transmitting the matched biopolymer array result to the communication address, and if the matched biopolymer array result is not found, transmitting status information to the communication address.23. The method of wherein the biopolymer arrays are polynucleotide arrays claim 22 , peptide arrays claim 22 , or a combination thereof.24. The method of claim 22 , further comprising:saving the communication address and the query array identifier in a memory, if the matched biopolymer array result is not found; andwhen the saved results are ...

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Номер записи: 7
22-03-2012 дата публикации

FLOW CELL EXPLOITING RADIATION WITHIN CELL WALL

Номер: US20120069340A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A flow cell () for a sample separation apparatus () for separating components of a sample fluid in a mobile phase, the flow cell () being configured for detecting the separated components and comprising a tubing () having an inner wall () and an outer wall (), the inner wall () defining a lumen () for conducting the sample fluid, the tubing () further having at one end an end face (), and a detection unit () configured for detecting electromagnetic radiation () exiting the end face () after propagation of the electromagnetic radiation () through the sample fluid in a portion of the lumen () and through a portion of the tubing () between the inner wall () and the outer wall (). 1. A flow cell for a sample separation apparatus for separating components of a sample fluid in a mobile phase , the flow cell being configured for detecting the separated components and comprising:a tubing having an inner wall and an outer wall, the inner wall defining a lumen for conducting the sample fluid, the tubing further having at one end an end face; anda detection unit configured for detecting electromagnetic radiation exiting the end face after propagation of the electromagnetic radiation through the sample fluid in a portion of the lumen and through a portion of the tubing between the inner wall and the outer wall.2. The flow cell according to claim 1 ,wherein the detection unit is configured for additionally detecting electromagnetic radiation after propagation entirely through the sample fluid in the lumen without propagating through the tubing between the inner wall and the outer wall.3. The flow cell according to claim 1 ,wherein the detection unit is configured for detecting the electromagnetic radiation after propagation partly through the sample fluid in the lumen and partly through the tubing and exiting via the end face of the tubing between the inner wall and the outer wall, the end face facing the detection unit.4. The flow cell according to claim 1 ,wherein the ...

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Номер записи: 8
29-03-2012 дата публикации

INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY APPARATUS AND MEASURED DATA PROCESSING METHOD IN THE INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY APPARATUS

Номер: US20120074309A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

The present invention performs measurement for determining a P/A coefficient and/or determination of the P/A coefficient after measurement of a standard density sample for density calibration in an ICP-MS. Specifically, after measuring signal intensity of each mass number in the standard density sample, the P/A coefficient is determined from the signal intensity for a mass number having the signal intensity within a P/A coefficient calibration range, while for a mass number having the signal intensity above the calibration range, a voltage applied to an ion lens of the ICP-MS is changed so that the signal intensity becomes within the calibration range, to thereby adjust an ion transmission ratio of the ion lens, and then the P/A coefficient is determined from the signal intensity determined within the calibration range. 1. An inductively coupled plasma mass spectroscopy apparatus , comprising:a sample input configured to introduce a sample to be measured;an ionizer configured to ionize an element in the sample;an ion lens into which the ionized element is provided, wherein the ion lens is configured to focus the ionized element;a mass analyzer configured to segregate the ionized element;an ion measuring part configured to measure a signal intensity corresponding to a number of ions having a mass number segregated by the mass analyzer as a pulse count value and an analog current value; andan operation processor configured to determine a pulse-to-analog (P/A) coefficient for converting the analog current value into the pulse count value from the analog current value measured by the ion measuring part and the corresponding pulse count value, wherein the operation processor is configured to determine the P/A coefficient of the mass number from the analog current value and the pulse count value corresponding to the signal intensity of the mass number.2. An inductively coupled plasma mass spectroscopy apparatus as claimed in claim 1 , wherein the signal intensity of the ...

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Номер записи: 9
29-03-2012 дата публикации

TANDEM PIEZOELECTRIC ACTUATOR AND SINGLE DRIVE CIRCUIT FOR ATOMIC FORCE MICROSCOPY

Номер: US20120079634A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus for atomic force microscopy (AFM) comprises a first actuator configured to move a cantilever along an axis; a second actuator configured to move the cantilever along the axis; an amplifier; and a crossover network connected between the amplifier, and the first actuator and the second actuator. The crossover network is adapted to provide a first drive signal to the first actuator over a first frequency range and to provide a second drive signal to the second actuator over a second frequency range. 1. An apparatus for atomic force microscopy (AFM) , comprising:a first actuator configured to move a cantilever along an axis;a second actuator configured to move the cantilever along the axis;an amplifier; anda crossover network connected between the amplifier, and the first actuator and the second actuator, wherein the crossover network is adapted to provide a first drive signal to the first actuator over a first frequency range and to provide a second drive signal to the second actuator over a second frequency range.2. An apparatus as claimed in claim 1 , wherein the first actuator has a first intrinsic capacitance and the crossover network forms a high pass frequency filter with the first intrinsic capacitance.3. An apparatus as claimed in claim 2 , wherein the second actuator has a second intrinsic capacitance and the crossover network forms a low pass frequency filter with the second intrinsic capacitance.4. An apparatus as claimed in claim 3 , wherein the high pass frequency filter and the low pass frequency filter are connected electrically in parallel.5. An apparatus as claimed in claim 1 , wherein the first actuator and the second actuator each comprise a piezoelectric element.6. An apparatus as claimed in claim 1 , further comprising a pre-amplifier connected to an input of the amplifier claim 1 , wherein the pre-amplifier equalizes a drive signal from the amplifier when an extension per unit voltage of the first actuator does not equal an extension ...

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Номер записи: 10
19-04-2012 дата публикации

METHODS AND APPARATUS FOR ACQUIRING PHYSICAL MEASUREMENTS RELATING TO A VESSEL AND A SHAFT WITHIN A VESSEL

Номер: US20120095723A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus is used for determining at least one parameter relating to an elongate member disposed within a vessel. The apparatus includes at least one measurement unit having a light emitting component and a corresponding light receiving component. The light receiving component is positioned apart from the light emitting component such that the elongate member is positionable between the light emitting component and the light receiving component. Additionally, the light emitting component is adapted to emit light towards the light receiving component, and the light receiving component is adapted to generate a signal corresponding to the light received from the light emitting component. A method for determining at least one parameter relating to the elongate member disposed within the vessel is also provided. 1. An apparatus for determining at least one parameter relating to an elongate member disposed within a vessel , comprising:at least one measurement unit having a light emitting component and a corresponding light receiving component, the light receiving component positioned apart from the light emitting component such that the elongate member is positionable between the light emitting component and the light receiving component;the light emitting component configured for emitting light towards the light receiving component; andthe light receiving component configured for generating a signal corresponding to the light received from the light emitting component.2. The apparatus of claim 1 , wherein the signal generated by the light receiving component is transmitted to a calculation unit and wherein the calculation unit is adapted to determine the at least one parameter based on the signal transmitted from the light receiving component.3. The apparatus of claim 2 , wherein the calculation unit is configured for determining at least one of:(a) a location of the elongate member relative to a vertical axis of the vessel;(b) an angular position of the elongate ...

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Номер записи: 11
26-04-2012 дата публикации

LIQUID CHROMATOGRAPHY ADJUSTMENT FOR METHOD-CONFORMALLY COMPENSATING DEVIATIONS FROM IDEAL BEHAVIOR

Номер: US20120096919A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A liquid chromatography device () being controllable for executing a chromatographic method () defined by a set of target parameters and by a corresponding target sequence of operation procedures, the device comprising a method execution unit () configured for executing the chromatographic method () by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device (), a determining unit () configured for determining a deviation of an actual result of the chromatographic method () from an expected target result, wherein the expected target result of the chromatographic method () represents a desired behavior of the liquid chromatography device () and wherein the actual result of the chromatographic method () is obtained by executing the chromatographic method () and represents an actual behavior of the liquid chromatography device (), and an adjusting unit () configured for adjusting at least one operation property of the liquid chromatography device () based on the determined deviation to thereby at least partially compensate a difference between the expected target result and the actual result while maintaining the chromatographic method () unchanged. 1. A liquid chromatography device being controllable for executing a chromatographic method defined by a set of target parameters and by a corresponding target sequence of operation procedures , the device comprising a method execution unit configured for executing the chromatographic method by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device; wherein the expected target result of the chromatographic method represents a desired behavior of the liquid chromatography device and', 'wherein the actual result of the chromatographic method is obtained by executing the chromatographic method and represents an actual behavior of the liquid ...

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Номер записи: 12
26-04-2012 дата публикации

Method and system of synchronizing data to reference time signal with data resampling

Номер: US20120099687A1
Автор: Gery VERHAEGEN, Tom Vandeplas
Принадлежит: AGILENT TECHNOLOGIES INC

A device receives a data signal and a reference timing signal provided from a first clock. The device includes a sample clock that operates independently from the first clock, wherein the sample clock outputs a sample clock signal that is asynchronous with the reference timing signal; a sampler for sampling a data signal in accordance with the sample clock signal and outputting a sampled data signal; and a resampler for resampling the sampled data signal according to a resampling ratio and outputting a resampled data signal such that a number of data samples in the resampled data signal within a synchronization time interval defined with respect to the reference timing signal equals a nominal number of data samples that would occur in the sampled data signal within the synchronization time interval when the sample clock signal was synchronized to the reference timing signal.

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Номер записи: 13
10-05-2012 дата публикации

PEAK CORRELATION AND CLUSTERING IN FLUIDIC SAMPLE SEPARATION

Номер: US20120116689A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A device () for analyzing measurement data having a plurality of data sets (), each data set () being assigned to a respective one of a plurality of measurements, each data set () having multiple features () being indicative of different fractions of a fluidic sample, the device () comprising a cluster determining unit () configured for determining feature clusters () by clustering features () from different data sets () presumably relating to the same fraction, a spread determining unit () configured for determining for at least a part of the feature clusters () a spread () of the features () within a respective feature cluster (), and a display unit () configured for displaying at least the part of the feature clusters () together with a graphical indication of the corresponding spread (). 1. A device for analyzing measurement data having a plurality of data sets , each data set being assigned to a respective one of a plurality of measurements , each data set having multiple features being indicative of different fractions of a fluidic sample , the device comprisinga cluster determining unit configured for determining feature clusters by clustering features from different data sets presumably relating to the same fraction;a spread determining unit configured for determining for at least a part of the feature clusters a spread of the features within a respective feature cluster;a display unit configured for displaying at least the part of the feature clusters together with a graphical indication of the corresponding spread.2. The device of claim 1 , wherein each feature represents a combination of a value of a first measurement parameter with a value of a second measurement parameter claim 1 , wherein the cluster determining unit is configured for:ordering at least a part of the features in accordance with the value of the first measurement parameter, particularly ordering from small to large values;determining the feature clusters by clustering features to a ...

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Номер записи: 14
17-05-2012 дата публикации

Rna labeling method

Номер: US20120122702A1
Автор: Emily Marine Leproust, Gusti Zeiner, Petula N. D'Andrade
Принадлежит: AGILENT TECHNOLOGIES INC

A method of sample analysis is provided. In certain embodiments, the method involves: a) obtaining a fragmented RNA sample comprising fragments of long RNA molecules and short RNA molecules; b) ligating an adaptor to an end of the RNA of the fragmented RNA sample to produce an adaptor-ligated sample; c) hybridizing said adaptor-ligated sample to an array of nucleic acid probes; and d) reading said array to obtain an estimate of the abundance of a long RNA in the RNA sample and an estimate of the abundance a small RNA in the RNA sample.

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Номер записи: 15
31-05-2012 дата публикации

PRESSURIZING SAMPLE LOOP BY SAMPLE METERING DEVICE

Номер: US20120132013A1
Автор: Glatz Bernd, Kretz Wolfgang
Принадлежит: AGILENT TECHNOLOGIES, INC.

A sample injector () for use in a fluid separation system () for separating compounds of a fluidic sample in a mobile phase, the sample injector () comprising a switchable valve (), a sample loop () in fluid communication with the valve () and configured for receiving the fluidic sample, a metering device () in fluid communication with the sample loop () and configured for introducing a metered amount of the fluidic sample on the sample loop (), and a control unit () configured for controlling switching of the valve () to transfer the sample loop () between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device () during the intermediate state to at least partially equilibrate a pressure difference in the sample loop () between the low pressure state and the high pressure state. 1. A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase , the sample injector comprising:a switchable valve;a sample loop in fluid communication with the valve and configured for receiving the fluidic sample;a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop;a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state, and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.2. The sample injector of claim 1 ,wherein the control unit is configured for controlling switching of the valve to transfer the sample loop from the high pressure state to the low pressure state via the intermediate state and for controlling the metering device during the intermediate state to perform a decompression in the sample loop before ...

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Номер записи: 16
21-06-2012 дата публикации

METHOD AND SYSTEM FOR PRODUCING A SIGNAL WITH A POWER CHANGE DETERMINED BY A PHASE OR FREQUENCY DIFFERENCE BETWEEN TWO SIGNAL SOURCES

Номер: US20120153933A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A system and method for determining the linearity of a device-under-test combine a first periodic signal and a second periodic signal to produce a combined signal, wherein the second periodic signal has at least one of a phase difference and a frequency difference with respect to the first periodic signal, and applying the combined signal to an input of the device-under-test. The linearity of the device-under-test is determined from an output signal of the device-under-test based on the at least one of the phase difference and frequency difference between the first periodic signal and the second periodic signal. 1. A method , comprising:combining a first periodic signal and a second periodic signal to produce a combined signal, wherein the second periodic signal has at least one of a phase difference and a frequency difference with respect to the first periodic signal;applying the combined signal to an input of a device; anddetermining a linearity of the device from an output signal of the device based on the at least one of the phase difference and frequency difference between the first periodic signal and the second periodic signal.2. The method of claim 1 , wherein the second periodic signal has the phase difference with respect to the first periodic signal claim 1 , and wherein the phase difference is varied to determine the linearity of the device.3. The method of claim 2 , further comprising comparing: (1) a measured response of the device as a function of a phase difference between a component of the first periodic signal present in the combined signal and a component of the second periodic signal present in the combined signal claim 2 , to (2) a theoretical response for an ideal linear device.4. The method of claim 2 , further comprising controlling a peak amplitude of a component of the first periodic signal present in the combined signal to be equal to a peak amplitude of a component of the second periodic signal present in the combined signal.5. The ...

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Номер записи: 17
21-06-2012 дата публикации

MRI Short Coils

Номер: US20120153955A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

According to one aspect, a magnetic resonance imaging (MRI) scanner includes a short birdcage (e.g. millipede) distributed-capacitance radio-frequency (RF) coil formed from one or more patterned planar conductive foils. The transverse extent (e.g. diameter) of the coil is at least a factor of 3, for example about a factor of 10, larger than the longitudinal (z-axis) extent of the coil. Flux-return gaps may be provided between the sample measurement volume defined by the coil and RF shields adjacent to the sample measurement volume, to confine the RF magnetic field to the sample measurement volume. Exemplary coils described herein are particularly suited for very high-frequency MRI measurements. 1. A magnetic resonance imaging (MRI) radio-frequency (RF) coil assembly comprising:a coil support; anda distributed-capacitance millipede MRI RF coil mounted on the coil support, the RF coil comprising a coil conductor formed from at least one patterned foil and defining a pair of longitudinally-spaced transverse conducting rings electrically interconnected by a plurality of longitudinal conducting strips, the RF coil being configured to generate a transverse RF magnetic field, wherein a transverse extent of a measurement volume defined within the RF coil exceeds a longitudinal extent of the measurement volume by at least a factor of 3.2. The coil assembly of claim 1 , wherein the transverse extent of the measurement volume exceeds the longitudinal extent of the measurement volume by less than a factor of 30.3. The coil assembly of claim 2 , wherein the transverse extent of the measurement volume exceeds the longitudinal extent of the measurement volume by a factor between 5 and 15.4. The coil assembly of claim 1 , further comprising a pair of coil RF shields situated on opposite longitudinal sides of the measurement volume claim 1 , the pair of RF shields being separated from the measurement volume by a corresponding pair of ring-shaped flux return gaps for longitudinally ...

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Номер записи: 18
28-06-2012 дата публикации

MULTI-CHANNEL FILTER ASSEMBLY AND RELATED APPARATUS AND METHODS

Номер: US20120159761A1
Автор: Fetvedt Jeremy
Принадлежит: AGILENT TECHNOLOGIES, INC.

A filter assembly includes a housing and filter elements. The housing includes internal chambers between first and second parallel outside surfaces, fluid inlet bores, and fluid outlet bores. Each internal chamber includes a filter element that partitions the internal chamber into an inlet chamber section and an outlet chamber section. The housing establishes a plurality of fluid flow channels from the inlet bores, through the inlet chamber sections, through the filter elements, through the outlet chamber sections and to the outlet bores, respectively. Each fluid channel includes a transverse fluid flow component in the inlet chamber section and the outlet chamber section. The filter assembly may be loaded into a filtering apparatus such that a plurality of separate fluid flow channels is established through the filter assembly. Fluid may be flowed through two or more of the fluid flow channels, wherein the fluid in each of the two or more fluid flow channels passes through the respective filter element and is filtered thereby. 1. A filter assembly , comprising: a first outside surface;', 'a second outside surface parallel to the first outside surface and spaced therefrom along a first axis;', 'a plurality of internal chambers between the first outside surface and the second outside surface, each internal chamber including a first inside surface lying along a second axis perpendicular to the first axis, a second inside surface parallel to the first inside surface, and a filter support extending from the second inside surface along the first axis, and each internal chamber having a chamber height along the first axis and a chamber diameter along the second axis greater than the chamber height;', 'a plurality of fluid inlet bores extending from the first outside surface to the respective first inside surfaces; and', 'a plurality of fluid outlet bores extending from the respective second inside surfaces to the second outside surface; and, 'a housing comprisinga ...

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Номер записи: 19
28-06-2012 дата публикации

LARGE-AREA SOLID PHASE EXTRACTION APPARATUS AND METHODS

Номер: US20120160038A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A solid phase extraction apparatus includes a sample adsorption assembly and a needle. The adsorption assembly includes a housing, a distal housing opening, and an adsorption bar disposed in the housing. The adsorption bar includes an outer surface coated with an adsorption material. The adsorption bar is located between the distal housing opening and a proximal housing opening. The outer surface is spaced from an inner housing surface, wherein the adsorption assembly includes an adsorption region between the inner housing surface and the outer surface. The adsorption assembly establishes a fluid flow path from the distal housing opening, through the adsorption region along a longitudinal direction, and to the proximal housing opening. The needle communicates with the distal housing opening 1. A solid phase extraction apparatus , comprising:a sample adsorption assembly comprising a housing, a proximal housing opening configured for communicating with a fluid moving device, a distal housing opening located at a distance from the proximal housing opening, and an adsorption bar disposed in the housing and comprising an outer surface and an adsorption material coating the outer surface, the adsorption bar having a predominant length in a longitudinal direction and located between the proximal housing opening and the distal housing opening, the outer surface spaced from an inner housing surface of the housing, wherein the sample adsorption assembly comprises a sample adsorption region between the inner housing surface and the outer surface and establishes a fluid flow path from the distal housing opening, through the sample adsorption region along the longitudinal direction, and to the proximal housing opening; anda needle communicating with the distal housing opening and disposed outside the housing.2. The solid phase extraction apparatus of claim 1 , wherein the outer surface of the adsorption bar has a transverse dimension orthogonal to the longitudinal direction ...

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Номер записи: 20
28-06-2012 дата публикации

DUAL MATERIAL APPROACH FOR HIGH PRESSURE BIO INERT FLOW PATH COMPONENTS

Номер: US20120160754A1
Автор: Falk-Jordan Stefan
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method of manufacturing a component () having a flow path (), wherein the method comprises forming a high pressure resistant casing () with a cavity () therein, inserting a bioinert material () into the cavity () to thereby form a composite block (), and further processing the composite block () for at least partially forming the flow path () defined by the component (). 1. A method of manufacturing a component having a flow path , the method comprisingforming a high pressure resistant casing with a cavity therein;inserting a bioinert material into the cavity to thereby form a composite block;further processing the composite block for at least partially forming the flow path defined by the component.2. The method of claim 1 , wherein inserting the bioinert material into the cavity comprises assembling a body of the bioinert material to the casing.3. The method of claim 2 , wherein the assembling comprises adhering the body to the casing using an adhesive.4. The method of claim 2 , wherein the assembling comprises:effecting a temperature difference between the body and the casing so that a temperature of the body is below a temperature of the casing,inserting the body into the casing while the temperature difference is maintained, andsubsequently thermally equilibrating the body and the casing.5. The method of claim 1 , wherein inserting the bioinert material into the cavity comprises injecting the bioinert material in a liquid state into the cavity claim 1 , and subsequently solidifying the bioinert material in the cavity.6. The method of claim 1 , wherein the composite block is further processed so that the flow path is delimited exclusively by bioinert material without direct contact between material of the casing and a fluid to be conducted along the flow path.7. The method of claim 1 , wherein the further processing comprises at least one of the group consisting of turning claim 1 , milling claim 1 , pressing claim 1 , and eroding.8. The method of claim 1 , ...

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Номер записи: 21
28-06-2012 дата публикации

CERAMIC INJECTION NEEDLE

Номер: US20120164026A1
Автор: Dehmer Bernhard, Wagner Joachim-Richard
Принадлежит: AGILENT TECHNOLOGIES, INC.

A needle () for handling a fluid in an analysis system (), the needle () comprising a needle body () made of a ceramic material and having a fluid conduit () extending between a fitting end () and a seat end (), the fitting end () being connectable to a fitting () and the seat end () being insertable into a seat (), wherein the needle body () is tapering, particularly conically tapering, towards the fitting end (), a fixing body () arranged on the needle body () next to the fitting end () for exerting an axial force when the needle body () is connected to the fitting (), and a slide-on element () to be slid over the needle body () so as to push the fixing body () towards the fitting end (). 1. A needle for handling a fluid in an analysis system , the needle comprising:{'b': '304', 'a needle body made of a ceramic material and having a fluid conduit () extending between a fitting end and a seat end, the fitting end being connectable to a fitting and the seat end being insertable into a seat, wherein the needle body is tapering, particularly conically tapering, towards the fitting end;'}a fixing body arranged on the needle body next to the fitting end for exerting an axial force when the needle body is connected to the fitting;a slide-on element to be slid over the needle body so as to push the fixing body towards the fitting end.2. The needle of claim 1 , wherein the fixing body is fixedly mounted on the needle body.3. The needle of claim 1 , wherein the fixing body is tapering claim 1 , particularly conically tapering claim 1 , towards the tapering claim 1 , particularly conically tapering claim 1 , of the needle body.4. The needle of claim 1 , wherein the fixing body is made of a ductile material claim 1 , and the needle body is made of a non-ductile material.5. (canceled)6. The needle of claim 1 , wherein the slide-on element has a tubular shape with an inner lumen for receiving the needle body and with a fitting fastener claim 1 , particularly an external thread ...

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Номер записи: 22
19-07-2012 дата публикации

PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS

Номер: US20120184724A1
Автор: Dellinger Douglas J., Dellinger Geraldine, Myerson Joel, Sierzchala Agnieszka B., Smart Brian Phillip, Timar Zoltan
Принадлежит: AGILENT TECHNOLOGIES, INC.

A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more H, C, or N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide. 2. The compound of wherein:{'sup': 1', '2, 'one of Rand Ris selected from a phosphoramidite group and a H-phosphonate group; and'}{'sup': 1', '2, 'one of Rand Ris a protecting group.'}6. The compound of wherein claim 5 , Ris DMT claim 5 , Ris beta-cyanoethyl-N claim 5 ,N-diisopropylphosphoramidite and BP is selected from the group consisting of U claim 5 , N-benzoyl-A claim 5 , N-isobutyryl-A claim 5 , N—(N claim 5 ,N)-dimethylacetamidine-A claim 5 , N—(N claim 5 ,N)-dibutylformamidine-A claim 5 , N-phenoxyacetyl-A claim 5 , N-4-tert-butylphenoxyacetyl-A claim 5 , N-acetyl-C claim 5 , N-isobutyryl-C claim 5 , N-phenoxyacetyl-C claim 5 , N-4-tert-butylphenoxyacetyl-C claim 5 , N-isobutyryl-G claim 5 , N—(N claim 5 ,N)-dibutylformamidine-G claim 5 , N—(N claim 5 ,N)-dimethylformamidine-G claim 5 , N-phenoxyacetyl-G and N-4-tert-butylphenoxyacetyl-G.7. A method of synthesizing a polynucleotide comprising at least one ribonucleotide residue claim 5 , said method comprising:contacting a nucleotide residue or a nucleoside monomer having an unprotected hydroxyl group with;{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'a compound of under conditions sufficient to covalently bond said compound to said nucleotide residue or said nucleoside monomer and produce said polynucleotide.'}8. The method of further comprising:contacting said polynucleotide with a composition comprising a sulfurization agent to produce an oxidized polynucleotide.9. The method of wherein said nucleotide residue or said nucleoside monomer is bound directly or indirectly to a solid support.10. The method according to claim 7 , further comprising:cleaving said ...

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Номер записи: 23
02-08-2012 дата публикации

MASS SPECTROMETER AND MASS ANALYZER COMPRISING PULSER

Номер: US20120193524A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite one another, parallel to one another, and axially offset from one another. One of the pair of planar electrodes comprises an opening. The mass analyzer comprises an ion mirror disposed between the pair of planar electrodes. A mass spectrometer and a mass spectrometry method are also described. 1. A mass spectrometer , comprising:a mass analyzer, comprising: a pair of planar electrode structures, an ion mirror disposed between the pair of planar electrodes, the electrode structures being disposed opposite one another, parallel to one another, and axially offset from one another, wherein one of the pair of planar electrodes comprises an opening;an ion source comprising: an ion pulser disposed outside of the mass analyzer and configured to direct ions into the opening in the one planar electrode; andan ion detector.2. A mass spectrometer as claimed in claim 1 , wherein the ion pulser comprises a grid configured to receive ions traveling in a plane parallel to a plane of the electrodes and to direct the ions to the opening.3. A mass spectrometer as claimed in claim 2 , wherein the grid is oriented along a second plane.4. A mass spectrometer as claimed in claim 1 , wherein the ion mirror is configured to reflect the ions in a direction parallel to a plane of the electrodes.5. A mass spectrometer as claimed in claim 1 , wherein the ion mirror comprises a single-stage ion mirror.6. A mass spectrometer as claimed in claim 1 , wherein the electrode structures are configured to generate claim 1 , in response to a common pattern of voltages applied thereto claim 1 , a cylindrically-symmetric claim 1 , annular electric field surrounding a cylindrical central region claim 1 , the electric field comprising an annular axially focusing lens region surrounding the central region claim 1 , and an annular mirror region surrounding the lens region.7. A mass spectrometer as ...

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Номер записи: 24
02-08-2012 дата публикации

Device and method for driving digital-to-analog converter

Номер: US20120194373A1
Автор: Gunter Steinbach
Принадлежит: AGILENT TECHNOLOGIES INC

A device for driving a switch in a digital-to-analog converter (DAC) includes first and second latches, and a logic gate. The first latch is configured to store a digital input data signal according to a clock signal, and to output a first latch signal corresponding to the stored digital input data signal. The second latch is configured to store the first latch signal output by the first latch according to a logical inverse of the clock signal, and to output a second latch signal corresponding to the stored first latch signal. The logic gate is configured to perform an OR logic operation on the first latch signal and the second latch signal, the logic gate outputting a drive signal for driving a switch in the DAC connected to a current source.

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Номер записи: 25
02-08-2012 дата публикации

Apparatus and methods for microfluidic applications

Номер: US20120195809A1
Автор: Douglas Roy, Joel Fearnley, Peter Ghazal, Stuart Polwart
Принадлежит: AGILENT TECHNOLOGIES INC

Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.

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Номер записи: 26
09-08-2012 дата публикации

COLUMN ASSEMBLY FOR A GAS CHROMATOGRAPH

Номер: US20120198913A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary column to the fluid in the tube. 1. A column assembly for gas chromatography , comprising:a capillary column for gas chromatography, wherein the capillary column comprises a front end and a rear end; anda tube having an exterior surface and defining a lumen,wherein the capillary column is arranged proximate the tube such that when a cooling fluid is passed through the lumen of the tube, a temperature of the capillary column is reduced.2. The column assembly of claim 1 , wherein the capillary column comprises a metal coating that can generate heat when an electric current is conducted therethrough.3. The column assembly of claim 1 , wherein the tube is made of a metal that can generate heat when an electric current is conducted therethrough.4. The column assembly of claim 3 , wherein the capillary column is helically wound around the tube.5. The column assembly of claim 1 , further comprising a heating element arranged in contact with at least a portion of the capillary column and a portion of the tube.6. The column assembly of claim 5 , wherein the heating element comprises an elongate wire claim 5 , and wherein the capillary column and the elongate wire are helically wound around the tube.7. The column assembly of claim 5 , wherein the heating element wraps around the tube claim 5 , and the capillary column wraps around a combination of the heating element and the tube.8. The column assembly of claim 5 , wherein the capillary column wraps around the tube claim 5 , and the heating ...

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Номер записи: 27
09-08-2012 дата публикации

LIQUID SUPPLY WITH OPTIMIZED SWITCHING BETWEEN DIFFERENT SOLVENTS

Номер: US20120198919A1
Автор: Choikhet Konstantin, Herzog Philip, Witt Klaus
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line. 1. A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture , the liquid supply system comprising a plurality of solvent supply lines , each fluidically connected with a reservoir containing a liquid , a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit , the proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit , with the pumping unit being configured for taking in liquids from the selected solvent supply lines and for supplying a mixture of the liquids at its outlet; the method comprising:drawing in a first liquid into the pumping unit via a first solvent supply line;determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range;switching from the first solvent ...

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Номер записи: 28
23-08-2012 дата публикации

SUSPENDED SUBSTRATE CIRCUITS AND NUCLEAR MAGNETIC RESONANCE PROBES UTILIZING SAME

Номер: US20120212224A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A nuclear magnetic resonance (NMR) probe circuit assembly includes one or more probe circuits in signal communication with one or more respective sample coils configured for transmitting and/or receiving radio-frequency (RF) energy to and/or from a sample of interest. One or more of the probe circuits have a suspended substrate configuration in which variable capacitors share a common dielectric substrate that is separated from a ground plane by an air gap. Each variable capacitor includes an electrode that is movable by a user-actuated adjusting device. One or more of the probe circuits may have a multiply resonant or broadband configuration, and may have one or more individual channels. One or more of the variable capacitors enable tuning to resonant frequencies of selected nuclei. One or more other variable capacitors may enable impedance matching. 1. A nuclear magnetic resonance (NMR) probe circuit assembly , comprising:a ground plane;a dielectric substrate separated from the ground plane by an air gap;a plurality of electrically conductive traces disposed on a surface of the dielectric substrate opposite to the air gap, and comprising a stationary capacitor electrode;a movable capacitor electrode interposed between the ground plane and the dielectric substrate, in movable contact with the ground plane and the dielectric substrate, and movable in variable overlapping relation with the stationary capacitor electrode, wherein the movable capacitor electrode, the dielectric substrate, and the stationary capacitor electrode form a variable capacitor configured for tuning the NMR probe circuit assembly to a resonance frequency; anda capacitor adjusting device configured for moving the movable capacitor electrode relative to the stationary capacitor electrode in response to actuation.2. The NMR probe circuit assembly of claim 1 , wherein the stationary capacitor electrode comprises a first conductive trace and a physically separate second conductive trace claim 1 , ...

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Номер записи: 29
30-08-2012 дата публикации

PRIMARY PISTON CORRECTION DURING TRANSFER

Номер: US20120216886A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle. 1. A method for controlling operation of a pump unit , the pump unit comprising a primary piston pump having a primary piston and a secondary piston pump having a secondary piston , the primary piston pump being fluidically connected with the secondary piston pump , the primary piston pump comprising an inlet valve and an outlet valve , and the pump unit operating periodically according to a pump cycle comprising a deliver-and-fill phase for delivering fluid from the primary piston pump to the secondary piston pump and to a fluidic system located downstream of the pump unit , the method comprising:determining a fluid pressure of fluid dispensed by the pump unit; andduring a first time interval of the pump cycle, performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit, while a predefined position-versus-time curve is performed by the secondary piston, wherein the first time interval corresponds to the deliver-and-fill phase.2. The method of claim 1 , whereinthe pump cycle comprises a deliver-and-fill phase for delivering fluid from the primary piston pump to the secondary piston pump and to a fluidic system located downstream of the pump unit, and the first time interval is the deliver-and-fill phase.3. The ...

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Номер записи: 30
30-08-2012 дата публикации

Probes for specific analysis of nucleic acids

Номер: US20120220479A1
Автор: Henrik Johansson, Magnus Isaksson, Olof Ericsson, Ulf Landegren
Принадлежит: AGILENT TECHNOLOGIES INC

The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said single-stranded portion is sufficient to allow hybridisation of at least part of the single-stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single-stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single-stranded portion of said target fragment, and comprising at the other end a second non-target-specific part which comprises a nucleotide sequence complementary to at least a portion, including one end, of oligonucleotide B of the probe, and (ii) oligonucleotide B is a single-stranded oligonucleotide which may contain or carry at least one element for detection and/or enrichment of said target fragment, and of which at least a portion, including one end, is complementary in sequence to the second non-target-specific part of oligonucleotide A, such that said target fragment becomes annealed to said probe through hybridisation to the first target-specific part of oligonucleotide A resulting in only one target-specific probe-binding event per target fragment; (d) ligating oligonucleotide B of said probe to the part of the single-stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) ...

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Номер записи: 31
20-09-2012 дата публикации

THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS

Номер: US20120238737A1
Автор: Caruthers Marvin H., Dellinger Douglas J., Dellinger Geraldine F., Ferreira Fernando, Kupihar Zoltan, Myerson Joel, Sierzchala Agnieszka, TURNER John
Принадлежит: AGILENT TECHNOLOGIES, INC.

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention. 8. The compound according to claim 1 , wherein{'sup': 'P', 'Bis a protected or unprotected heterocyclic base;'}{'sup': 1', '2', '1', '2, 'one of Rand Ris a protecting group, and the other of Rand Ris a phosphoramidite group.'}10. The method according to claim 9 , wherein said method further comprises exposing said internucleotide bond to an oxidizing agent.11. The method according to claim 10 , wherein said method further comprises reiterating said contacting step at least once.12. The method according to claim 9 , wherein said method further comprises removing said 2′-hydroxyl protecting group.13. The method according to claim 9 , wherein said nucleoside residue is covalently bound to a solid support.14. The method according to claim 13 , wherein said method further comprises cleaving said nucleic acid from said solid support to produce a free nucleic acid.19. The method according to claim 9 , further comprising:(c) oxidizing said internucleotide bond to produce a nucleic acid;(d) cleaving said nucleic acid from said solid support to produce a free nucleic acid; and(e) chemically modifying said free nucleic acid to produce a modified nucleic acid. This application is a divisional and claims the benefit of application Ser. No. 12/118,655, filed on May 9, 2008, which claims the benefit under 35 U.S.C. §119(e) of prior U.S. provisional application Ser. No. 60/928,722 filed May 10, 2007. These prior applications are incorporated by reference in their entirety.Chemical synthesis of RNA is a ...

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Номер записи: 32
27-09-2012 дата публикации

METHOD AND SYSTEM FOR PROVIDING PHASE REFERENCE SIGNAL

Номер: US20120243595A1
Автор: Anderson Keith F., Betts Loren C.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method and system of providing a phase reference signal includes generating a reference signal having a reference frequency, modulating the reference signal at a modulation frequency lower than the reference frequency to obtain a modulated drive signal, receiving the modulated drive signal at a phase reference, and generating the phase reference signal based on the modulated drive signal. The phase reference signal including multiple reference tones having corresponding tone frequencies clustered around multiples of the reference frequency. A spacing between adjacent tones of the multiple reference tones is the same as the modulation frequency or an integer multiple of the modulation frequency. 1. A method of providing a phase reference signal , comprising:generating a reference signal having a reference frequency;modulating the reference signal at a modulation frequency lower than the reference frequency to obtain a modulated drive signal;receiving the modulated drive signal at a phase reference signal generator; andgenerating the phase reference signal based on the modulated drive signal, the phase reference signal comprising a plurality of reference tones having corresponding tone frequencies clustered around multiples of the reference frequency, wherein a spacing between adjacent tones of the plurality of reference tones is the same as the modulation frequency or an integer multiple of the modulation frequency.2. The method of claim 1 , wherein modulating the reference signal comprises amplitude modulating the reference signal to obtain an amplitude modulated drive signal.3. The method of claim 2 , wherein the amplitude modulated drive signal comprises a reference signal with at least one of a square waveform modulation envelope claim 2 , a rectangular waveform modulation envelope claim 2 , and a pseudo random binary sequence (PRBS) waveform modulation envelope.4. The method of claim 1 , wherein modulating the reference signal comprises frequency modulating ...

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Номер записи: 33
04-10-2012 дата публикации

FLUIDIC CHIP WITH LAMINATED REINFORCING LAYER FOR PRESSURE REINFORCEMENT

Номер: US20120251410A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fluidic chip device configured for processing a fluidic sample includes two outer boundary layers, and at least one reinforcing layer arranged between the two outer boundary layers and being at both of its opposing main surfaces laminated with directly adjacent layers to reinforce pressure resistance of the fluidic chip device by the lamination, in which at least a part of the layers of the fluidic chip device includes a hole forming at least a part of a fluidic conduit for conducting the fluidic sample under pressure. 1. A fluidic chip device configured for processing a fluidic sample , the fluidic chip device comprisingtwo outer boundary layers;at least one reinforcing layer arranged between the two outer boundary layers and being at both of its opposing main surfaces laminated with directly adjacent layers to reinforce pressure resistance of the fluidic chip device by the lamination;wherein at least a part of the layers of the fluidic chip device comprises a hole forming at least a part of a fluidic conduit for conducting the fluidic sample under pressure.2. The fluidic chip device according to claim 1 , wherein the at least one reinforcing layer is laminated with the directly adjacent layers over an entire surface area of both of its main surfaces.3. The fluidic chip device according to claim 1 , wherein the at least one reinforcing layer is glued at both of its opposing main surfaces with the directly adjacent layers.4. The fluidic chip device according to any of the preceding claim 1 , wherein the at least one reinforcing layer is in direct contact with plastic material at both opposing main surfaces.5. The fluidic chip device according to any of the preceding claim 1 , wherein at least one of the at least two outer boundary layers comprises a hole forming part of the fluidic conduit.6. The fluidic chip device according to any of the preceding claim 1 , wherein at least one of the at least one reinforcing layer comprises a hole forming part of the fluidic ...

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Номер записи: 34
18-10-2012 дата публикации

BALANCED FEATURE DISPLAY IN FLUIDIC SAMPLE SEPARATION

Номер: US20120265448A1
Автор: Frank Michael
Принадлежит: AGILENT TECHNOLOGIES, INC.

A device for processing measurement data assigned to a measurement on a fluidic sample to be separated, the measurement data having multiple features being indicative of different fractions of the fluidic sample, the device includes a feature position analysis unit configured for analyzing positions (p, p, d, d) of at least a part of the features relative to one another, and a display adjustment unit configured for adjusting, based on a result of the analyzing, a mode of displaying at least a part of the features along at least one display axis of a display diagram so that at least a part of adjacent features is positioned equidistantly along the at least one display axis or so that at least a part of adjacent features is positioned to have a distance (d) from one another which is larger than or equal to a predefined threshold value (d). 1. A device for processing measurement data assigned to a measurement on a fluidic sample to be separated , the measurement data having multiple features being indicative of different fractions of the fluidic sample , the device comprising{'sub': 1', '2', '1', '2, 'a feature position analysis unit configured for analyzing positions (p, p, d, d) of at least a part of the features relative to one another;'} at least a part of adjacent features is positioned equidistantly along the at least one display axis; or', {'sub': 'th', 'at least a part of adjacent features is positioned to have a distance (d) from one another which is larger than or equal to a predefined threshold value (d).'}], 'a display adjustment unit configured for adjusting, based on a result of the analyzing, a mode of displaying at least a part of the features along at least one display axis of a display diagram so that'}2. The device of claim 1 , wherein the display adjustment unit is configured for adjusting the mode of displaying so that all features are located equidistantly along the at least one display axis or all adjacent features are positioned to have a ...

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Номер записи: 35
25-10-2012 дата публикации

OSCILLOSCOPE WITH INTEGRATED GENERATOR AND INTERNAL TRIGGER

Номер: US20120268101A1
Автор: Weller Dennis J.
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus, includes an oscilloscope and a waveform generator. The waveform generator is integrated in a common housing with the oscilloscope, and configured to provide a stimulus signal as an output of the apparatus and to provide a trigger signal that is connected internally to the oscilloscope for triggering the oscilloscope. 1. An apparatus , comprising:an oscilloscope; anda waveform generator integrated in a common housing with the oscilloscope, and configured to provide a stimulus signal as an output of the apparatus and to provide a trigger signal that is connected internally to the oscilloscope for triggering the oscilloscope.2. An apparatus as claimed in claim 1 , the oscilloscope comprising:a switch connected to the waveform generator and configured to receive the trigger signal, and connected to a channel input block and configured to receive a channel input signal.3. An apparatus as claimed in claim 2 , wherein the switch is configured to selectively provide the trigger signal and the channel input signal to trigger display of the channel input signal by the oscilloscope.4. An apparatus as claimed in claim 2 , wherein the switch is further connected to an external block to receive a signal that is external to the apparatus claim 2 , and configured to selectively provide the trigger signal claim 2 , the channel input signal and the signal from the external block to trigger display of the channel input signal by the oscilloscope.5. An apparatus as claimed in claim 1 , wherein the stimulus signal is output to a device-under-test that is external to the apparatus claim 1 , the device-under-test is responsive to the stimulus signal to output a signal that is connected to the apparatus for display by the oscilloscope.6. An apparatus as claimed in claim 1 , wherein the waveform generator comprises:a memory configured to output digitized samples of stored waveforms;a converter configured to convert the digitized samples to an analog signal; anda comparator ...

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Номер записи: 36
01-11-2012 дата публикации

Oscilloscope with internally generated mixed signal oscilloscope demo mode stimulus, and integrated demonstration and training signals

Номер: US20120274313A1
Автор: Dennis J. Weller, Matthew S. Holcomb, Thomas Schmidt
Принадлежит: AGILENT TECHNOLOGIES INC

An oscilloscope includes at least one demonstration signal generator integrated as part of the oscilloscope. The demonstration signal generator generates stimulus signals that consist of digital samples of various different stored waveforms without the need of a separate demonstration board or signal source. The demonstration signal generator may loop through different sections of the stored waveforms to generate respective stimulus signals that include sequences of digital samples from the different waveforms in combination, to provide a broad range of stimulus signals. The stimulus signals may be displayed on the oscilloscope or output from the oscilloscope as demonstration mode stimulus signals to demonstrate the capabilities of the oscilloscope to customers or for training.

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Номер записи: 37
15-11-2012 дата публикации

PUMP REDUCING A FLUID FLOW BY A DETERMINED AMOUNT

Номер: US20120285558A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fluid pump for a fluid separation device for separating a fluid includes a fluid inlet being supplyable with fluid at an inlet pressure (pI), and a fluid conducting mechanism configured for conducting the fluid supplied to the fluid inlet towards a connected fluidic path, in which the fluid conducting mechanism is controllable so that, regardless of a value of the inlet pressure (pI), the fluid is continuously conducted away from the fluid inlet with a definable flow rate (FT). 1. A fluid pump for a fluid separation device for separating a fluid , the fluid pump comprising:a fluid inlet being supplyable with fluid at an inlet pressure (pI); 'wherein the fluid conducting mechanism is controllable so that, regardless of a value of the inlet pressure (pI), the fluid is continuously conducted away from the fluid inlet with a definable flow rate (FT).', 'a fluid conducting mechanism configured for conducting the fluid supplied to the fluid inlet towards a connected fluidic path;'}2. The fluid pump according to claim 1 , further comprising a control unit configured for controlling the fluid conducting mechanism so that claim 1 , regardless of the value of the inlet pressure (pI) claim 1 , the fluid is continuously conducted away from the fluid inlet with the definable claim 1 , particularly with a constant claim 1 , flow rate (FT).3. The fluid pump according to claim 1 , wherein the fluid conducting mechanism is manually controllable so that claim 1 , regardless of a value of the inlet pressure (pI) claim 1 , the fluid is continuously conducted away from the fluid inlet with the definable claim 1 , particularly with a constant claim 1 , flow rate (FT).4. The fluid pump according to claim 1 , wherein the fluid conducting mechanism is controllable so that claim 1 , regardless of the value of the inlet pressure (pI) claim 1 , the fluid is continuously conducted away from the fluid inlet with a constant flow rate (FT).5. The fluid pump according to claim 1 , wherein the ...

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Номер записи: 38
15-11-2012 дата публикации

METHOD FOR AMPLIFICATION OF TARGET NUCLEIC ACID

Номер: US20120289426A1
Автор: Ericsson Olle (Olof), Fredriksson Simon, Isaksson Magnus, Johansson Henrik, Nilsson Mats, Roos Fredrik
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for amplifying a target nucleic acid is disclosed, which includes: (a) fragmenting a nucleic acid sample to create a target fragment comprising a target nucleic acid and two probe-complementary portions; (b) contacting said fragmented nucleic acid sample with a probe comprising two target fragment-complementary portions complementary to the probe-complementary portions of the target fragment; (c) rendering the fragmented nucleic acid sample single-stranded; (d) allowing the probe-complementary portions to hybridise with the target-fragment complementary portions; (e) if the probe in step (b) is not immobilised, immobilising the probe-target fragment hybrid on a solid phase via immobilisation moiety; (f) separating non-immobilised nucleic acid fragments from the solid phase; (g) contacting the solid phase with a ligase to ligate ligatable 5′ and 3′ ends of the target fragment whereby the target fragment is circularized; and (h) amplifying said circularized target fragment.

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Номер записи: 39
15-11-2012 дата публикации

PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS

Номер: US20120289691A1
Автор: Dellinger Douglas J., Dellinger Geraldine F., Myerson Joel, Sierzchala Agnieszka, Timar Zoltan
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure:

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Номер записи: 40
22-11-2012 дата публикации

SYSTEM FOR CHARACTERIZING MIXER OR CONVERTER RESPONSE

Номер: US20120295548A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A network analyzer comprises: a signal source configured to supply an input signal to a device, wherein the device is configured to generate a phase reference signal; a receiver configured to receive the phase reference signal from the device and to measure a phase response of the device according to the phase reference signal; and a calibration component configured to compare the measured phase response of the device with an actual phase response of the device to identify a tracking parameter for the receiver. 1. A method of calibrating a network analysis system comprising a device measurement path located between a first receiver and a second receiver , the method comprising:determining a phase response of the first receiver independent of the second receiver;determining a phase response of the second receiver; anddetermining a phase tracking response from the phase response of the first receiver and the phase response of the second receiver to establish a calibration of the device measurement path.2. The method of claim 1 , wherein the phase response of the second receiver is determined independent of the first receiver.3. The method of claim 1 , further comprising:determining scattering parameters (S-parameters) for the device measurement path;determining a tracking parameter of the device measurement path from the S-parameters,wherein the phase response of the second receiver is determined from the tracking parameter and the phase response of the first receiver.4. The method of claim 1 , wherein determining the phase response of the first receiver comprises:measuring a raw phase response of a device using the first receiver; andmodifying the raw phase response according to an actual phase response of the device.5. The method of claim 4 , wherein modifying the raw phase response comprises dividing the raw phase response by the actual phase response of the device.6. The method of claim 4 , further comprising applying a smoothing function to the actual phase ...

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Номер записи: 41
29-11-2012 дата публикации

AUTOMATIC GAIN TUNING IN ATOMIC FORCE MICROSCOPY

Номер: US20120304343A1
Автор: MOON Christopher Ryan
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for optimizing loop gain of an atomic force microscope (AFM) apparatus includes determining a change in gain of the physical system and adjusting a controller frequency response of the controller in an AFM loop to compensate for the determined change in gain. The AFM loop has a corresponding loop response that includes the product of the controller frequency response and a physical system response of the physical system. 1. A method for optimizing loop gain of an atomic force microscope (AFM) apparatus comprising a controller and a physical system , the method comprising:determining a change in gain of the physical system; andadjusting a controller frequency response of the controller in an AFM loop to compensate for the determined change in gain, the AFM loop having a corresponding loop response comprising the product of the controller frequency response and a physical system response of the physical system.2. The method of claim 1 , wherein adjusting the controller frequency response comprises:dividing an initial controller frequency response by the determined change in the gain.3. The method of claim 2 , wherein determining the change in the gain comprises:measuring the physical system response at a predetermined frequency at a first time;measuring the physical system response at the predetermined frequency at a subsequent second time; anddetermining the ratio of the physical system response measured at the first time and the physical system response measured at the second time.4. The method of claim 1 , further comprising:initially shaping the loop response of the AFM loop, wherein shaping the loop response comprises selecting an initial controller frequency response to cause the loop response to have a desired shape.5. The method of claim 4 , wherein shaping the loop response compensates for resonances of the physical system response.6. The method of claim 1 , wherein adjusting the controller frequency response to compensate for a subsequent change is ...

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Номер записи: 42
20-12-2012 дата публикации

ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND METHOD

Номер: US20120318973A1
Автор: Goodley Paul C., JR. Harvey D., Loucks
Принадлежит: AGILENT TECHNOLOGIES, INC.

An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore. 1. An atmospheric pressure ionization apparatus , comprising:a housing comprising a chamber;an ion inlet structure comprising a sampling orifice coaxial with a sampling axis and communicating with the chamber;an electrode comprising an electrode bore and spaced from the ion inlet structure, wherein an ionization region is defined between the ion inlet structure and the electrode;a flared structure coaxially disposed about the ion inlet structure and extending along an outward direction that includes a radial component relative to the sampling axis;a sample emitter disposed in the chamber and oriented at an angle to the sampling axis for directing a sample stream toward the ionization region; anda gas passage configured for directing a stream of gas from a gas source to the chamber,wherein the flared structure forms a portion of the gas passage, the portion extending annularly about the sampling axis and along the outward direction, and the gas flows through the portion, ...

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Номер записи: 43
03-01-2013 дата публикации

MICROFLUIDIC DEVICE AND EXTERNAL PIEZOELECTRIC ACTUATOR

Номер: US20130000758A1
Автор: Brennen Reid, Chang Dustin, Hoen Storrs T., Killeen Kevin P.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fluid pumping device includes a piezoelectric actuator externally coupled to a microfluidic device. The piezoelectric actuator has an axial displacement along a lengthwise axis responsive to application of a bias voltage. The axial displacement of the piezoelectric actuator operates one of an internal valve and an internal pump chamber of the microfluidic device. 1. A fluid transfer device , comprising:a piezoelectric actuator externally coupled to a microfluidic device, the piezoelectric actuator having an axial displacement along a lengthwise axis responsive to application of a bias voltage, the axial displacement of the piezoelectric actuator operating one of an internal valve and an internal pump chamber of the microfluidic device.2. The device of claim 1 , further comprising:a high-stiffness actuator coupled to the piezoelectric actuator, and configured to dynamically adjust a position of the piezoelectric actuator relative to the microfluidic device.3. The device of claim 1 , wherein the axial displacement of the piezoelectric actuator is less than about 10 μm.4. A fluid transfer device claim 1 , comprising:a microfluidic device comprising a pump chamber; anda first piezoelectric actuator coupled to the microfluidic device, and configured to extend and contract along a first lengthwise axis in response to selective application of a first bias voltage to compress the pump chamber, wherein the first piezoelectric actuator is external to the microfluidic device.5. The device of claim 4 , wherein internal walls of the microfluidic device and the pump chamber are coated with a non-reactive coating.6. The device of claim 4 , wherein the first piezoelectric actuator comprises one of a stacked piezoelectric actuator or a piezoelectric tube.7. The device of claim 4 , further comprising:a high-stiffness actuator coupled to the piezoelectric actuator, and configured to adjust a position of the piezoelectric actuator in relation to the microfluidic device, wherein the ...

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Номер записи: 44
03-01-2013 дата публикации

MICROFLUIDIC DEVICE AND EXTERNAL PIEZOELECTRIC ACTUATOR

Номер: US20130000759A1
Автор: Brennen Reid A., Chang Dustin, Hoen Storrs T., Killeen Kevin P.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fluid pumping device includes a piezoelectric actuator externally coupled to a microfluidic device. The piezoelectric actuator has an axial displacement along a lengthwise axis responsive to application of a bias voltage. The axial displacement of the piezoelectric actuator operates one of an internal valve and an internal pump chamber of the microfluidic device. 1. A fluid transfer device , comprising:a piezoelectric actuator externally coupled to a microfluidic device, the piezoelectric actuator having an axial displacement along a lengthwise axis responsive to application of a bias voltage, the axial displacement of the piezoelectric actuator operating one of an internal valve and an internal pump chamber of the microfluidic device.2. The device of claim 1 , further comprising:a high-stiffness actuator coupled to the piezoelectric actuator, and configured to dynamically adjust a position of the piezoelectric actuator relative to the microfluidic device.3. The device of claim 1 , wherein the axial displacement of the piezoelectric actuator is less than about 10 μm.4. The device of claim 1 , wherein the bias voltage is applied to the piezoelectric actuator in a periodic fashion to cause the one of the internal valve and the internal pump chamber to enable fluid pumping functionality.5. The device of claim 1 , wherein the bias voltage is applied to the piezoelectric actuator continuously to maintain a constant axial displacement and to cause the one of the internal valve and the internal pump chamber to provide flow restriction functionality.6. A fluid transfer device claim 1 , comprising:a microfluidic device comprising a first valve having a valve chamber, operation of the first valve enabling fluid to enter or exit the valve chamber through a port; anda first piezoelectric actuator coupled to the microfluidic device, and configured to extend along a first lengthwise axis in response to application of a first bias voltage to close the first valve, and to ...

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Номер записи: 45
03-01-2013 дата публикации

Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography

Номер: US20130001145A1
Автор: Bai Qing, Brennen Reid A., Yin Hongfeng
Принадлежит: AGILENT TECHNOLOGIES, INC.

A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes. A micro-machined integrated frit and flow distributor device is also provided having a substrate with a thickness, holes extending through the thickness and providing fluid communication therethrough, and channels in fluid communication with at least one of the holes. A chromatography column is provided having a tube, an extraction medium contained therein, and a micro-machined frit positioned proximate an end of the tube. The column can include a micro-machined flow distributor positioned between the frit and the end of the tube. 1. A micro-machined frit for use in a chromatography column , said frit comprising:a substrate having a first surface, an oppositely disposed second surface, and a thickness, said substrate defining a plurality of holes extending through said thickness, each of said holes having a first end positioned on said first surface and an opposed second end positioned on said second surface, wherein for each of said holes, said first end is aligned with said second end, and wherein said holes provide fluid communication therethrough said substrate.2. The frit of claim 1 , wherein said holes are arranged in an array.3. The frit of claim 1 , further comprising:a plurality of first slots formed in said first surface and substantially parallel to one another; anda plurality of second slots formed in said second surface and substantially parallel to one another, said plurality of second slots being oriented transversely to said plurality of first slots, wherein said plurality of first slots intersect said plurality of second slots thereby forming said plurality ...

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Номер записи: 46
03-01-2013 дата публикации

Windowless ionization device

Номер: US20130001416A1
Автор: James Edward COOLEY, Sameer KOTHARI
Принадлежит: AGILENT TECHNOLOGIES INC

An ionization device comprises: a plasma source configured to generate a plasma. The plasma comprises light, plasma ions and plasma electrons. The plasma source comprises an aperture disposed such that at least part of the light passes through the aperture and is incident on a gas sample. The ionization device further comprises an ionization region; and a plasma deflection device comprising a plurality of electrodes configured to establish an electric field, wherein the electric field substantially prevents the plasma ions from entering the ionization region.

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Номер записи: 47
03-01-2013 дата публикации

NUCLEAR MAGNETIC RESONANCE PROBE COMPRISING SLIT SUPERCONDUCTING COIL WITH NORMAL-METAL OVERLAYER

Номер: US20130002251A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A nuclear magnetic resonance (NMR) probe comprises a superconducting material formed in a spiral having a plurality of fingerlets separated by a plurality of slits, and a normal-metal overlayer formed on the spiral over the plurality of fingerlets and the plurality of slits. 1. A nuclear magnetic resonance (NMR) probe coil , comprising:a superconducting material formed in a spiral having a plurality of fingerlets separated by a plurality of slits; anda normal-metal overlayer formed on the spiral over the plurality of fingerlets and the plurality of slits.2. The NMR probe coil of claim 1 , wherein the superconducting material comprises yttrium barium copper oxide.3. The NMR probe coil of claim 1 , wherein the normal-metal layer is formed of gold.4. The NMR probe coil of claim 1 , wherein the superconducting material is formed on a planar substrate comprising synthetic sapphire.5. The NMR probe coil of claim 1 , further comprising a second NMR probe coil formed in a back-to-back configuration and in counterwound direction relative to the NMR probe coil.6. The NMR probe coil of claim 5 , wherein the second NMR probe coil comprises a superconducting material without a normal-metal overlayer.7. The NMR probe coil of claim 1 , wherein each of the fingerlets has a width of about 10 μm or less claim 1 , and each of the slits has a width of about 3 μm or less.8. The NMR probe coil of claim 1 , wherein the normal-metal overlayer has a thickness of about 300 nm or less.9. The NMR probe coil of claim 1 , wherein the normal-metal overlayer is receded inward from a pair of outermost fingerlets of the spiral.10. The NMR probe coil of claim 9 , wherein the normal-metal overlayer is receded inward by a distance of about one third of the width of the outermost fingerlets or less.11. The NMR probe coil of claim 1 , wherein the fingerlets have semicircular ends.12. The NMR probe coil of claim 1 , wherein the normal-metal overlayer is formed over the superconducting material in a ...

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Номер записи: 48
03-01-2013 дата публикации

CONSTANT SWITCHING CURRENT FLIP-FLOP

Номер: US20130002325A1
Автор: LEE Minjae
Принадлежит: AGILENT TECHNOLOGIES, INC.

A constant switching current flip-flop includes a latch circuit that provides latch outputs of the flip-flop, whereby the latch outputs are reset to zero at the beginning of each clock cycle to eliminate pattern dependent switching currents. The latch circuit is reset responsive to control signals provided without significant delay. 1. A flip-flop comprising:an amplifier configured to provide an amplified output responsive to input data and a clock; anda latch configured to provide a latch output that is reset to zero during a reset period at the beginning of each clock cycle of the clock responsive to at least one control signal, and to provide a latch output responsive to the amplified output after the reset period of each clock cycle.2. The flip-flop of claim 1 , further comprising:a generator configured to generate the at least one control signal responsive to the amplified output provided each clock cycle.3. The flip-flop of claim 2 , wherein the at least one control signal comprises first and second control signals claim 2 , and the generator comprises:a first inverter configured to invert the amplified output;a buffer configured to delay an output of the first inverter; anda second inverter configured to invert an output of the buffer,wherein the output of the first inverter is provided as the first control signal, and an output of the second inverter is provided as the second control signal.4. The flip-flop of claim 3 , wherein the latch comprises first and second transistors connected in series between an output node of the latch and ground claim 3 , and is configured to reset the latch output during the reset period responsive to the first and second control signals.5. The flip-flop of claim 4 , wherein the latch further comprises a third transistor connected between the output node of the latch and a power supply claim 4 , the third transistor configured to disconnect the power supply from the output node during the reset period.6. The flip-flop of claim ...

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Номер записи: 49
03-01-2013 дата публикации

IMPAIRMENT COMPENSATION

Номер: US20130003799A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC

A method is provided for compensating for impairment of an electrical signal output from a device under test (DUT), the impairment resulting from an impairment network. The method includes measuring an impaired electrical signal received at an electronic analyzer via the impairment network; applying a coded pulse sequence to the impairment network; estimating an impairment transfer function corresponding to the impairment based on the applied pulse sequence; and correcting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT. 1. A method of compensating for impairment of an electrical signal output from a device under test (DUT) , the impairment resulting from an impairment network , the method comprising:measuring an impaired electrical signal received at an electronic analyzer via the impairment network;applying a coded pulse sequence to the impairment network;estimating an impairment transfer function corresponding to the impairment based on the applied coded pulse sequence; andcorrecting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT.2. The method of claim 1 , wherein the impairment network comprises a cable and at least one connector connecting the DUT and the electronic analyzer.3. The method of claim 2 , wherein the impairment network further comprises at least one internal component of the electronic analyzer that drifts with time or at least one internal component of the DUT.4. The method of claim 1 , wherein estimating the impairment transfer function comprises inferring the impairment transfer function using S-parameter Sof the impairment network.5. The method of claim 1 , wherein estimating the impairment transfer function comprises directly measuring the impairment transfer function using one of S-parameter Sor Sof the impairment network.6. The method of claim 1 , wherein estimating the impairment transfer ...

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Номер записи: 50
03-01-2013 дата публикации

IMPAIRMENT COMPENSATION

Номер: US20130003804A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC

A method is provided for compensating for impairment of an electrical signal output from a device under test (DUT), the impairment resulting from an impairment network. The method includes measuring an impaired electrical signal received at an electronic analyzer via the impairment network; applying a stimulus signal to the impairment network; estimating an impairment transfer function corresponding to the impairment based on the applied stimulus signal; and correcting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT. 1. A method of compensating for impairment of an electrical signal output from a device under test (DUT) , the impairment resulting from an impairment network , the method comprising:measuring an impaired electrical signal received at an electronic analyzer via the impairment network;applying a stimulus signal to the impairment network;estimating an impairment transfer function corresponding to the impairment based on the applied stimulus signal; andcorrecting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT.2. The method of claim 1 , wherein the applied stimulus signal comprises a coded pulse sequence.3. The method of claim 1 , wherein the impairment network comprises a cable and at least one connector connecting the DUT and the electronic analyzer.4. The method of claim 2 , wherein the impairment network further comprises at least one internal component of the electronic analyzer that drifts with time or at least one internal component of the DUT.5. The method of claim 1 , wherein estimating the impairment transfer function comprises inferring the impairment transfer function using S-parameter Sof the impairment network or directly measuring the impairment transfer function using one of S-parameter Sor Sof the impairment network.6. The method of claim 1 , wherein estimating the impairment transfer ...

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Номер записи: 51
03-01-2013 дата публикации

SUPERFICIALLY POROUS METAL OXIDE PARTICLES, METHODS FOR MAKING THEM, AND SEPARATION DEVICES USING THEM

Номер: US20130004772A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

Superficially porous hybrid particles include hybrid solid cores that each contain an inorganic material and an organic material; and porous hybrid outer shells each include the inorganic and organic materials and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 Å with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01° and 10° of a 2θ scan range; wherein the particles have a median size range from about 0.5 μm to about 100 μm with a particle size distribution (one standard deviation) of no more than 15% of the median particle size, wherein the inorganic material comprises a metal oxide selected from silica, alumina, titania or zirconia. 1. Superficially porous particles , comprising:solid cores each comprising an inorganic material or a hybrid material, said hybrid material including an inorganic material and an organic material; andporous outer shells each comprising the inorganic material or the hybrid material, and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 Å with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01° and 10° of a 20 scan range;wherein the particles have a median size range from about 0.5 μm to about 100 μm with a particle size distribution (one standard deviation) of no more than 15% of the median particle size,wherein the inorganic material comprises a metal oxide selected from silica, alumina, titania or zirconia.2. The superficially porous particles of claim 1 , wherein the solid cores each comprise the inorganic material and the porous outer shells each comprise the inorganic material.3. The superficially porous particles of claim 1 , wherein the solid cores each comprise the inorganic material and the porous outer ...

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Номер записи: 52
10-01-2013 дата публикации

DRIFTING TWO-DIMENSIONAL SEPARATION WITH ADAPTION OF SECOND DIMENSION GRADIENT TO ACTUAL FIRST DIMENSION CONDITION

Номер: US20130008859A1
Автор:
Принадлежит: AGILENT TECHNOLOGIES, INC.

A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed. 1. A control device for a sample separation apparatus for separating a fluidic sample , the sample separation apparatus comprising a first separation unit supplyable with the fluidic sample to be separated and a second separation unit downstream of the first separation unit and supplyable with the fluidic sample after treatment by the first separation unit , wherein the control device is configured for:controlling the first separation unit to execute a primary separation sequence within a measurement time interval for separating the fluidic sample into a plurality of fractions;controlling the second separation unit to execute a plurality of secondary separation sequences within the measurement time interval for further separating at least a part of the separated plurality of fractions into a plurality of sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set ...

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Номер записи: 53
10-01-2013 дата публикации

Method for positioning an atomic force microscopy tip in a cell

Номер: US20130014295A1
Автор: Bo U. Curry, Chriatian Rankl, Nazumi Alice Yamada
Принадлежит: AGILENT TECHNOLOGIES INC

A method for positioning a tip of an atomic force microscope relative to a intracellular target site in a cell is provided. In general terms, the method comprises: a) positioning a fluorescent tip of an atomic force microscope over a cell comprising a fluorescent intracellular target site so that said tip is above target site; b) moving the tip toward said target site while obtaining images of the distal end of said tip and/or the target site using a fluorescence microscope; and c) arresting the movement of the tip when the target site and the distal end of the tip are both in focus in the fluorescence microscope. A microscope system for performing the method is also provided.

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Номер записи: 54
17-01-2013 дата публикации

APPARATUS AND METHODS FOR ACQUIRING ANALYTES FROM A DRIED BIOLOGICAL FLUID SAMPLE

Номер: US20130017545A1
Автор: Hudson William C., Yong Ben
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus for acquiring analytes from a dried biological fluid sample includes a tube, a substrate in a proximal section of the tube, and a sorbent bed in a distal section of the tube. A biological fluid sample is dispensed on the substrate and is dried to form a dried sample. A conditioning solvent is flowed into the distal section to condition the sorbent bed. A first elution solvent is flowed through the substrate and the sorbent bed. Analytes are eluted from the dried sample and retained on the sorbent bed. A second elution solvent is flowed through the substrate and the sorbent bed. The analytes are eluted from the sorbent bed, pass through an opening, and are collected. Alternatively, an elution solvent is flowed through the substrate and the sorbent bed such that analytes eluted from the dried sample pass through the sorbent bed and the opening for collection, while non-analytes are retained on the sorbent bed. 1. A method for acquiring analytes from a dried biological fluid sample , the method comprising:dispensing a biological fluid sample on a substrate disposed in a fixed position in a proximal section of a tube;drying the biological fluid sample on the substrate to form a dried biological fluid sample;flowing a conditioning solvent into a distal section of the tube adjoining the proximal section to condition a sorbent bed disposed in a fixed position in the distal section;flowing a first elution solvent through the substrate and the sorbent bed, wherein analytes are eluted from the dried biological fluid sample and retained on the sorbent bed;flowing a second elution solvent through the substrate and the sorbent bed, wherein the analytes are eluted from the sorbent bed and pass through an opening of the distal section; andcollecting the analytes passing through the opening.2. The method of claim 1 , comprising claim 1 , before dispensing the biological fluid sample claim 1 , installing the substrate in the proximal section.3. The method of claim 2 , ...

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Номер записи: 55
31-01-2013 дата публикации

GAS CHROMATOGRAPH PROVIDING SEMI-AUTOMATIC IDENTIFICATION OF CONNECTED SAMPLE FLOW COMPONENTS, AND METHOD OF OPERATING SAME

Номер: US20130025347A1
Автор: Rhodes Robert P., Wilson William H.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for semi-automatically generating configuration information for a gas chromatograph uses an identification device reader of the gas chromatograph to 1) determine a presence and location of sample flow component identification devices in or on identification device holders that hold the sample flow component identification devices; 2) read information from sample flow component identification devices held in the identification device holders; and 3) output configuration information for the gas chromatograph. The configuration information is based on the presence and location of particular sample flow component identification devices in or on particular identification device holders, and on associations of particular identification device holders with particular sample flow component connections to the gas chromatograph. The configuration information indicates if and how sample flow components are connected to the gas chromatograph. 1. A gas chromatograph , comprising:a plurality of identification device holders for holding sample flow component identification devices associated with sample flow components connectable to the gas chromatograph, wherein particular identification device holders are associated with particular connections of sample flow components to the gas chromatograph; andan identification device reader configured to i) determine a presence and location of sample flow component identification devices in or on the identification device holders, ii) read information from sample flow component identification devices held in the identification device holders, and iii) output configuration information for the gas chromatograph, the configuration information based on the presence and location of particular sample flow component identification devices in or on particular identification device holders, and the configuration information based on the associations of particular identification device holders with particular connections of sample flow ...

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Номер записи: 56
31-01-2013 дата публикации

DRIFT STABILIZATION OF MAGNETICALLY TUNABLE FILTER BY TEMPERATURE REGULATION AND MECHANICAL ISOLATION OF ELCTROMAGNET COIL

Номер: US20130027152A1
Автор: CASSANEGO Paul E., MAKER Charles, RATH Darrin D.
Принадлежит: AGILENT TECHNOLOGIES, INC.

An electromagnet structure comprises a magnetic shell having a cavity, a magnetic pole located within the cavity and having a magnetic gap for focusing a magnetic field on a magnetically tunable filter, a conductive coil located within the cavity of the magnetic shell and forming multiple turns around the magnetic pole, and a heater located within the cavity of the magnetic shell and configured to maintain the conductive coil at a substantially constant temperature when the magnetically tunable filter is tuned to different frequencies. 1. An electromagnet structure , comprising:a magnetic shell comprising a cavity;a magnetic pole located within the cavity and having a magnetic gap for focusing a magnetic field on a magnetically tunable filter;a conductive coil located within the cavity of the magnetic shell and forming multiple turns around the magnetic pole; anda heater located within the cavity of the magnetic shell and configured to maintain the conductive coil at a substantially constant temperature when the magnetically tunable filter is tuned to different frequencies.2. The electromagnet structure of claim 1 , further comprising a pedestal located within the cavity claim 1 , wherein the conductive coil is mounted on the pedestal.3. The electromagnet structure of claim 2 , further comprising:a heat spreader formed outside the magnetic shell; andpedestal legs connected between the pedestal and the heat spreader.4. The electromagnet structure of claim 3 , wherein the pedestal legs pass through holes in the magnetic shell.5. The electromagnet structure of claim 1 , wherein the heater comprises independent resistive elements that receive electrical currents in opposite directions around the magnetic pole.6. The electromagnet structure of claim 1 , wherein the heater is controlled such that a substantially constant amount of power is applied to the heater and the conductive coil while the magnetically tunable filter is tuned to different frequency ranges.7. The ...

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Номер записи: 57
31-01-2013 дата публикации

PCI-E SYSTEM HAVING RECONFIGURABLE LINK ARCHITECTURE

Номер: US20130031288A1
Автор: RICHARD Jared
Принадлежит: AGILENT TECHNOLOGIES, INC.

A peripheral component interconnect express (PCI-E) system has a reconfigurable link architecture. The system comprises a system slot adapted to receive a PCI-E compatible system controller, a plurality of peripheral slots adapted to receive a plurality of peripheral modules, and a reconfigurable switch fabric configured to create a variable number of PCI-E links between the system slot and the plurality of peripheral slots. 1. A peripheral component interconnect express (PCI-E) system having a reconfigurable link architecture , comprising:a system slot adapted to receive a PCI-E compatible system controller;a plurality of peripheral slots adapted to receive a plurality of peripheral modules; anda reconfigurable switch fabric configured to create a variable number of PCI-E links between the system slot and the plurality of peripheral slots.2. The PCI-E system of claim 1 , wherein the system slot and the peripheral slots are located on a backplane of a PXI-E chassis.3. The PCI-E system of claim 2 , wherein all of the peripheral slots on the backplane are hybrid-compatible PXI-E slots.4. The PCI-E system of claim 2 , wherein the reconfigurable switch fabric is located on a mezzanine card in the PXI-E chassis.5. The PCI-E system of claim 3 , wherein the reconfigurable switch fabric is located on a mezzanine card in the PXI-E chassis.6. The PCI-E system of claim 1 , further comprising:a nonvolatile memory storing a first switch image for a 2-link configuration of the reconfigurable switch fabric, and a second switch image for a 4-link configuration of the reconfigurable switch fabric.7. The PCI-E system of claim 1 , wherein the reconfigurable switch fabric is configurable to a 2-link PCI-E configuration of a PXI-E chassis claim 1 , and is also configurable to a 4-link PCI-E configuration of a PXI-E chassis.8. The PCI-E system of claim 1 , wherein the reconfigurable switch fabric comprises two partitionable switches.9. The PCI-E system of claim 1 , wherein the system ...

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Номер записи: 58
07-02-2013 дата публикации

USE OF N-ALKYL IMIDAZOLE FOR SULFURIZATION OF OLIGONUCLEOTIDES WITH AN ACETYL DISULFIDE

Номер: US20130035261A1
Автор: Dellinger Douglas J., Metz Paul A., Mokler Victor R., Sierzchala Agnieszka B.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources. 1. A method of sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide , the method comprising:contacting an oligonucleotide comprising a phosphite or thiophosphite intermediate with a composition comprising an acetyl disulfide, a solvent, and a nucleophilic acylation catalyst, for a time sufficient to convert the phosphite or thiophosphite intermediate to a phosphorothioate or phosphorodithioate;wherein the nucleophilic acylation catalyst is at up to 25% (v/v) in the solvent.2. The method of claim 1 , wherein the nucleophilic acylation catalyst is an N-alkyl imidazole.3. The method of claim 2 , wherein the N-alkyl imidazole is N-methyl imidazole.4. The method of claim 1 , wherein the solvent is at least 80% (v/v) of the composition.5. The method of claim 2 , wherein the N-alkyl imidazole is at 10% (v/v) or less in the solvent.6. The method of claim 1 , wherein the solvent is a high dielectric constant solvent.7. The method of claim 5 , wherein said solvent comprises acetonitrile or propylene carbonate.8. The method of claim 7 , wherein the solvent is acetonitrile.9. The method of claim 1 , wherein the solvent is a low dielectric constant solvent.10. The method of claim 9 , wherein said solvent comprises toluene claim 9 , xylene claim 9 , 2-methyl THF claim 9 , cyclopentyl methyl ether or 1-methylpyrrolidinone.11. The method of claim 10 , wherein the solvent is toluene.12. The method of claim 2 , wherein the N-alkyl imidazole is at least 5% in volume (v/v) in the solvent.13. The method of claim 12 , wherein the acetyl disulfide is at least at 0.1M concentration in said solvent.14. The method of claim 1 , wherein the oligonucleotide is bound to a ...

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Номер записи: 59
21-02-2013 дата публикации

CALIBRATION OF MASS SPECTROMETRY SYSTEMS

Номер: US20130043380A1
Автор: CORREALE RAFFAELE
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for operating a mass spectrometer (MS) includes establishing a pressure differential across a membrane wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source on a downstream side of the membrane; flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source; and maintaining the upstream pressure at a constant value. The calibrant may be flowed at a low flow rate. An MS system includes a membrane interposed between a calibrant gas introduction system and a mass spectrometer. The membrane may include an orifice of nano-scale diameter. 1. A method for operating a mass spectrometer (MS) , the method comprising:establishing a pressure differential across a membrane of the MS wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source of the MS on a downstream side of the membrane;flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source at a nanoflow flow rate; andwhile flowing the calibrant gas, maintaining the upstream pressure at a constant value.2. The method of claim 1 , comprising maintaining the downstream pressure in the ion source in a range from 10mbar to 10mbar.3. The method of claim 1 , wherein the constant value of the upstream pressure ranges from 0.1 mbar to 1000 mbar.4. The method of claim 1 , wherein flowing the calibrant gas flows through the nano-scale orifice is done at a flow rate ranging from 10sccm to 10sccm.5. The method of claim 1 , comprising operating the ion source to produce calibrant ions and operating a detector of the MS to generate a calibrant ion signal.6. The method of claim 5 , comprising adjusting an intensity of the calibrant ion signal by adjusting the upstream pressure to a new value claim 5 , and ...

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Номер записи: 60
14-03-2013 дата публикации

IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS

Номер: US20130062515A1
Автор: FREED MICHAEL K., PREST HARRY F., QUIMBY BRUCE D., SZELEWSKI MICHAEL J.
Принадлежит: AGILENT TECHNOLOGIES, INC.

In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. 1. A method for operating a mass spectrometer (MS) system , the method comprising:introducing a sample and a carrier gas into an ionization chamber of the MS system; andflowing a conditioning gas into a mass spectrometer of the MS system, wherein the conditioning gas in the mass spectrometer does not substantially change the mass spectral characteristics of analytes of the sample, and the conditioning gas is different from the carrier gas.2. The method of claim 1 , wherein the conditioning gas is selected from the group consisting of hydrogen claim 1 , argon claim 1 , and both hydrogen and argon.3. The method of claim 2 , wherein the carrier gas comprises helium and the conditioning gas comprises hydrogen.4. The method of claim 1 , further comprising flowing a reagent gas into the ionization chamber to perform chemical ionization on the sample.5. The method of claim 1 , wherein the conditioning gas is flowed with an auxiliary gas different from the conditioning gas claim 1 , from a source containing a blend of the conditioning gas and the auxiliary gas.6. The method of claim 1 , wherein flowing the conditioning gas comprises flowing the ...

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Номер записи: 61
21-03-2013 дата публикации

SINGLE INJECTION VALVE FOR HPLC COMBINING SAMPLE INTRODUCTION, WASH CYCLES AND DIAGNOSIS

Номер: US20130067997A1
Автор: Ebsen Johnny, Wetzel Matthias
Принадлежит: AGILENT TECHNOLOGIES, INC.

A switchable valve for a sample injector includes a first valve member and a second valve member that can moved with respect to the other. The first valve member includes a plurality of ports, the second valve member includes a plurality of fluid paths. The plurality of ports include eight circumferential ports distributed along a circumference and one central port arranged at a central position of the first valve member. The plurality of fluid paths include three arcuate fluid paths so as to be couplable with at least two of the circumferential ports and one straight fluid path extending between the central position and a circumferential position so as to be couplable with the central port and one of the circumferential ports. 1. A switchable valve for a sample injector for use in a fluid separation system for separating compounds of a sample fluid in a mobile phase , the switchable valve comprising:a first valve member and a second valve member, wherein at least one of the first and second valve members is configured to be moved with respect to the other;the first valve member comprises a plurality of ports,the second valve member comprises a plurality of fluid paths for fluidly coupling respective ones of the ports in dependency on a relative movement position of the first and second valve members with respect to each other;wherein the plurality of ports comprise eight circumferential ports distributed along a circumference of the first valve member and comprise one central port arranged at a central position of the first valve member;wherein one of the circumferential ports has an extension groove;wherein the plurality of fluid paths comprise three arcuate fluid paths each being arcuate so as to be couplable with at least two of the circumferential ports;wherein the plurality of fluid paths comprise one straight fluid path extending between the central position and a circumferential position so as to be couplable with the central port and with one of the ...

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Номер записи: 62
28-03-2013 дата публикации

Characterization and correction of voltage probe, current probe and cable

Номер: US20130076372A1
Автор: David Dascher
Принадлежит: AGILENT TECHNOLOGIES INC

Responses of voltage and current probes are characterized or corrected. A voltage probe method includes measuring output of the voltage probe and a first output of a through, in response to an input signal applied to the through, with the voltage probe connected, measuring a second output of the through with the voltage probe disconnected, and characterizing the response of the voltage probe using the output of the voltage probe and the first and/or second outputs. A current probe method includes measuring output current of the current probe and first output current of a through, in response to an input signal applied to the through with the current probe connected in series, measuring second output current of the through with the current probe disconnected, and characterizing the response of the current probe using the output current of the current probe and the first and/or second output currents of the through.

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Номер записи: 63
04-04-2013 дата публикации

CLOSED CORE CURRENT PROBE

Номер: US20130082695A1
Автор: Johnson Kenneth W.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A current probe enabling measurement of current of a signal in a circuit includes a ferrite core defining a gap, a wire wrapped around the ferrite core and a magnetic field sensor. The wire is configured to receive the signal from the circuit, where the current of the signal flowing in the wire generates a magnetic field in the ferrite core. The magnetic field sensor is positioned in the gap of the ferrite core, the magnetic field generated in the ferrite core flowing through the magnetic field sensor, which produces a voltage proportional to an intensity of the magnetic field. The current is measured based on the voltage produced by the magnetic field sensor. 1. A current probe enabling measurement of current of a signal in a circuit , the current probe comprising:a ferrite core defining a gap;a wire wrapped around the ferrite core and configured to receive the signal from the circuit, wherein the current of the signal flowing in the wire generates a magnetic field in the ferrite core; anda magnetic field sensor positioned in the gap of the ferrite core, the magnetic field generated in the ferrite core flowing through the magnetic field sensor, which produces a voltage proportional to an intensity of the magnetic field, wherein the current is measured based on the voltage produced by the magnetic field sensor.2. The current probe of claim 1 , wherein the magnetic field sensor comprises a Hall Effect sensor.3. The current probe of claim 2 , wherein a direction of the magnetic field corresponds to phase of the current of the signal flowing in the wire claim 2 , and wherein phase of the voltage produced by the magnetic field sensor is determined by the direction of the magnetic field.4. The current probe of claim 1 , wherein gain of the magnetic field sensor increases proportionally to increases in the number of windings of the wire around the ferrite core claim 1 , increasing sensitivity of the current probe.5. The current probe of claim 1 , further comprising:a ...

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Номер записи: 64
04-04-2013 дата публикации

PARALLEL MAGNETIC RESONANCE IMAGING USING GLOBAL VOLUME ARRAY COIL

Номер: US20130082709A1
Автор: ANDERSON Weston A., RATH Alan R., WONG Wai Ha
Принадлежит: AGILENT TECHNOLOGIES, INC.

A magnetic resonance imaging (MRI) apparatus comprises a plurality of cylindrical electromagnetic coils arranged in a coaxial configuration around a sample region. The coils are used to capture resonance signals from a sample at different times according to a geometric echo effect. The measurements can then be combined to produce an MRI signal. 1. A method of operating a magnetic resonance imaging (MRI) apparatus comprising a plurality of cylindrical electromagnetic coils arranged in a coaxial configuration around a sample region and tuned to a common frequency , the method comprising:applying a static magnetic field to a sample located within the sample region to align nuclear dipoles of the sample;applying a perturbation signal to the sample using one of the coils;applying a field gradient to the sample along a center axis of the coils; anddetecting resonance signals at the respective coils in succession according to a geometric echo effect determined by different electromagnetic profiles of the coils.2. The method of claim 1 , wherein the coils detect the resonance signals at different times separated by an interval τ=2π/(γG*FOV) claim 1 , where γ represents a gyromagnetic ratio of the sample claim 1 , Grepresents a magnitude of the field gradient claim 1 , and FOV represents a length of a radio frequency (RF) window of the coils.3. The method of claim 1 , wherein the coils are inductively isolated with respect to each other according to their respective geometries.4. The method of claim 1 , wherein the coils are birdcage coils or millipede coils.5. The method of claim 4 , wherein a first one of the coils is a straight type birdcage coil claim 4 , a second one of the coils is a spiral type birdcage coil with a twist angle of 360 degrees claim 4 , and a third one of the coils is a spiral type birdcage coil with a twist angle of negative 360 degrees.6. The method of claim 4 , wherein the coils comprise four spiral type birdcage coils with respective twist angles of ...

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Номер записи: 65
04-04-2013 дата публикации

REDUCING METASTABILITY IN ANALOG TO DIGITAL CONVERSION

Номер: US20130082854A1
Автор: KEANE John Patrick
Принадлежит: AGILENT TECHNOLOGIES, INC.

A system for performing analog-to-digital conversion comprises a sampling unit that generates multiple digital samples from an analog input signal at each recurrence of a periodic interval, and a processing unit that combines the digital samples to produce a digital output signal. In certain embodiments, the sampling unit comprises multiple analog-to-digital converters arranged in parallel, and the processing unit comprises a digital signal processor that detects outliers in the digital samples and averages any non-outliers among the digital samples to generate the digital output signal. 1. A system for performing analog-to-digital conversion , comprising:a sampling unit configured to generate multiple digital samples from an analog input signal at each recurrence of a periodic interval, the sampling unit comprising multiple analog-to-digital converters (ADCs) that operate in parallel to separately receive and digitize the analog input signal to produce the digital samples; anda processing unit configured to combine the digital samples to produce a digital output signal, wherein the processing unit determines when any of the digital samples is an outlier and averages digital samples that are not determined to be outliers.2. The system of claim 1 , wherein the sampling unit further includes a sample and hold (S/H) circuit configured to sample the analog input signal and provide the sampled analog input signal to each of the multiple ADCs.3. The system of claim 1 , wherein the sampling unit further includes multiple sample and hold (S/H) circuits each configured to sample the analog input signal and to provide the sampled analog input signal to a corresponding one of the multiple ADCs.4. The system of claim 1 , further comprising multiple offset circuits each introducing an offset into the analog input signal provided to a corresponding one of the multiple ADCs.5. The system of claim 1 , further comprising multiple offset circuits each configured to introduce an ...

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Номер записи: 66
25-04-2013 дата публикации

IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS

Номер: US20130099113A1
Автор: FREED MICHAEL K., PREST HARRY F., QUIMBY BRUCE D., SZELEWSKI MICHAEL J.
Принадлежит: AGILENT TECHNOLOGIES, INC.

In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. 120.-. (canceled)21. A method for operating a mass spectrometer (MS) system , the method comprising:introducing a sample and a carrier gas into an ionization chamber of the MS system; andflowing a conditioning gas into the MS system, the conditioning gas comprising hydrogen gas, wherein the conditioning gas in the MS system does not substantially change the mass spectral characteristics of analytes of the sample, and the carrier gas does not comprise hydrogen gas.22. The method of claim 21 , wherein the MS system comprises a collision cell.23. The method of claim 22 , wherein the conditioning gas is flowed directly into the collision cell.24. The method of claim 22 , wherein the conditioning gas is flowed into the MS system upstream from the collision cell.25. The method of claim 22 , wherein the conditioning gas is flowed into the MS system downstream from the collision cell.26. The method of claim 21 , wherein the conditioning gas is flowed directly into an ion detector of the MS system.27. The method of claim 21 , wherein the carrier gas comprises helium.28. The method of claim 21 , wherein the carrier gas is helium and the conditioning gas ...

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Номер записи: 67
25-04-2013 дата публикации

Inorganic/Organic Hybrid Totally Porous Metal Oxide Particles, Methods For Making Them And Separation Devices Using Them

Номер: US20130102459A1
Автор: Barber William E., Chen Wu, Wei Ta-Chen
Принадлежит: AGILENT TECHNOLOGIES, INC.

The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation. 122-. (canceled)24. The totally porous particles of claim 23 , wherein the totally porous particles exhibit at least one X-ray diffraction peak between 0.01° and 10° of the 2θ scan range.25. The totally porous particles of claim 23 , wherein M is Si.26. The totally porous particles of claim 23 , wherein Ris independently selected in each instance from methyl or ethyl and Ris selected from methylene claim 23 , ethylene or 1 claim 23 ,2-benzylene.27. (canceled)28. (canceled)29. The totally porous particles of claim 23 , wherein the totally porous particles are created by reacting silica claim 23 , titania or zirconia particles with an organic metal alkoxide.30. The totally porous particles of claim 23 , wherein the median size of the totally porous particles is from about 0.5 μm to about 10 μm.31. The totally porous particles of claim 23 , wherein the pore size ranges from about 60 Å to about 800 Å.32. The totally porous particles of claim 23 , wherein the specific surface area of the totally porous particles is from about 5 m/g to about 300 m/g.33. (canceled)34. (canceled)36. The totally porous particles of claim 35 , wherein the totally porous particles are created by reacting alumina particles with an organic metal alkoxide.37. The totally porous particles of claim 35 , wherein the median size of the totally porous particles is from about 0.5 μm to about 10 μm.38. The totally porous particles of claim 35 , wherein the pore size ranges from about 60 Å to about 800 Å.39. The totally porous particles of claim 35 , wherein the specific surface area of the totally porous particles is from about 5 m/g to about 300 m/g.40. (canceled)41. (canceled)43. Totally porous particles claim 35 , comprising: [{'br': None, 'sub': 2', '3', 'x', 'y, 'sup': 1', '1, 'AlO/(RAlO ...

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Номер записи: 68
02-05-2013 дата публикации

OSCILLOSCOPE PROBE COMPRISING STATUS INDICATOR

Номер: US20130106401A1
Автор: Johnson Kenneth W., McTigue Michael T.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A system comprises an oscilloscope and an oscilloscope probe having a status indicator. The status indicator is located on a probe head of the oscilloscope probe and is configured to convey information to a user to indicate at least one characteristic of the signal. In certain embodiments, the status indicator comprises a light or a screen to convey signal related information to the user. 1. A system , comprising:an oscilloscope probe comprising a probe head having a probe tip and configured to transmit a signal from the probe tip to an oscilloscope; anda status indicator located on the probe head and configured to convey information to a user to indicate at least one characteristic of the signal.2. The system of claim 1 , wherein the at least one characteristic of the signal comprises whether the signal is toggling or whether the signal is a direct current voltage above a predetermined threshold.3. The system of claim 1 , wherein the status indicator comprises a light that turns on or off to indicate the at least one characteristic of the signal.4. The system of claim 3 , wherein the light flashes to indicate that the signal has a first characteristic claim 3 , and maintains a persistent “on” state to indicate that the signal has a second characteristic.5. The system of claim 1 , further comprising a comparator located in the oscilloscope probe claim 1 , wherein the comparator compares the signal against a predetermined criterion and communicates with the status indicator to indicate that the signal meets the criterion.6. The system of claim 5 , wherein the predetermined criterion is whether the signal has an amplitude above a user-defined threshold.7. The system of claim 5 , wherein the oscilloscope probe further comprises a pod and a cable connected between the probe head and the pod claim 5 , and wherein the comparator is coupled to the pod.8. The system of claim 1 , wherein the status indicator comprises a display screen that presents graphical information ...

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Номер записи: 69
02-05-2013 дата публикации

AUTOMATIC TUNING OF ATOMIC FORCE MICROSCOPE

Номер: US20130110262A1
Автор: Abramovitch Daniel Y., MOON Christopher Ryan
Принадлежит: AGILENT TECHNOLOGIES, INC.

An atomic force microscope (AFM) comprises a physical system and a controller comprising a plurality of digital filters and configured to control the physical system. The AFM is tuned by performing automatic loop shaping on a loop response defined by a frequency response of the physical system and a frequency response of the controller, and adjusting a gain of the controller according to a peak in a magnitude of the loop response. 1. A method of tuning an atomic force microscope (AFM) comprising a physical system and a controller configured to control the physical system , the method comprising:determining a loop response of the AFM based on a frequency response of the physical system and a frequency response of the controller;determining a cost function indicating a difference between the loop response and a target response characteristic; andadjusting the frequency response of the controller to reduce the difference.2. The method of claim 1 , wherein the controller comprises a plurality of digital filters each characterized by one or more filter coefficients claim 1 , and adjusting the frequency response of the controller comprises updating the filter coefficients of one or more of the digital filters.3. The method of claim 2 , wherein the plurality of digital filters comprises at least one proportional-integral derivative (PID) filter and at least one biquadratic filter.4. The method of claim 2 , further comprising adjusting a gain of the controller after adjusting the frequency response of the controller.5. The method of claim 1 , wherein the target response characteristic is a desired loop shape claim 1 , and the cost function is based on a difference between a magnitude of the loop response and the desired loop shape.6. The method of claim 5 , wherein the cost function is a root mean squared difference between the magnitude of the loop response and the desired shape.7. The method of claim 1 , wherein adjusting the frequency response of the controller comprises ...

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Номер записи: 70
02-05-2013 дата публикации

CALIBRATING RECONSTRUCTED SIGNAL USING MULTI-TONE CALIBRATION SIGNAL

Номер: US20130110442A1
Автор: NISHIMURA Ken A., RUSH Kenneth
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method of calibrating a reconstructed signal from a plurality of sub-signals is provided. The method includes injecting a calibration signal having multiple tones into a received input signal; dividing the input signal into a first and second sub-signal, including an overlapping frequency band; performing a first frequency translation by converting frequency components of the second sub-signal; digitizing the first sub-signal and the frequency converted second sub-signal; performing a second frequency translation to reverse the first frequency translation to obtain a reconstructed second sub-signal; and quantifying impairments to the digital first sub-signal and reconstructed second sub-signal caused by differences in magnitude and phase of frequency components within the overlapping frequency band. 1. A method of calibrating a reconstructed signal from a plurality of sub-signals , the method comprising:injecting a calibration signal into a received input signal, the calibration signal comprising a plurality of tones;dividing the input signal with the injected calibration signal into at least a first sub-signal having a first frequency band and a second sub-signal having a second frequency band, wherein a portion of the first frequency band overlaps a portion of the second frequency band to form an overlapping frequency band;performing a first frequency translation by converting frequency components of the second sub-signal within the second frequency band to obtain a frequency converted second sub-signal;digitizing the first sub-signal and the frequency converted second sub-signal;quantifying impairments to the first sub-signal and the second sub-signal caused by differences in magnitude and phase of frequency components of the first and second sub-signals within the overlapping frequency band; andperforming a second frequency translation to reverse the first frequency translation by converting the frequency components of the digital frequency converted second ...

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Номер записи: 71
09-05-2013 дата публикации

WESTERN BLOT ANALYTICAL TECHNIQUE

Номер: US20130115714A1
Автор: Macnamara Kenneth G., Polwart Stuart
Принадлежит: AGILENT TECHNOLOGIES INC

In accordance with an embodiment of the present invention, there is provided a method of performing the western blot analytical technique, wherein the method comprises carrying out the following steps in the following order: a), pre-staining the proteins within a sample; b). separating the proteins using gel electrophoresis; c). analysing the separated proteins to determine the total protein load and/or at least one housekeeping protein load; d). transferring the proteins onto at least one membrane; e). probing the separated proteins to detect a target protein; and f). analysing the probed proteins to determine the target protein's molecular weight and/or load. 1. A method of performing the Western blot analytical technique , wherein the method is carried our in the following order:a), pre-staining the proteins within a sample;b). separating the proteins using gel electrophoresis;c). analysing the separated proteins to determine the total protein load and/or at least one housekeeping protein load;d). transferring the proteins onto at least one membrane;e). probing the separated proteins to detect a target protein; andf). analysing the probed proteins to determine the target protein's molecular weight and/or load.2. The method according to claim 1 , wherein the total protein load and/or housekeeping protein load are compared to the target protein load to find the ratio of total protein and/or housekeeping protein load to target protein load.3. The method according to claim 2 , wherein the protein load is calculated as the area under a curve of intensity of fluorescence plotted against the position of said fluorescence in an electrophoresis gel or plotted against the time said fluorescence is detected at a fixed point from the start of protein separation.4. The method according to claim 3 , wherein the total protein load is determined to be the complete area under the curve of a plot of fluorescence intensity against position of said fluorescence in an electrophoresis ...

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Номер записи: 72
16-05-2013 дата публикации

MULTI-SITE MUTAGENESIS

Номер: US20130122550A1
Автор: CLINE Janice Marie, HOGREFE Holly Hurlbut
Принадлежит: AGILENT TECHNOLOGIES, INC.

The present invention provides compositions and improved methods for multi-site directed mutagenesis and DNA shuffling. The present compositions and methods provide increased mutation frequency and increased number of transformants which allow one to sequence only a few clones in order to identify the correct mutants and to obtain the desired mutant by screening large number of transformants in a short time. Moreover, the inclusion of FEN-1, PEF and optimized buffer and cycling conditions provided in the present invention should also facilitate random mutagenized library construction and the mutagenesis of large or difficult templates. 1. A method for introducing two or more mutations to a target DNA molecule , said method comprising:a) annealing one or more primers to the same strand of said DNA molecule, wherein each said primer comprises at least one mutation site with respect to said DNA molecule;b) synthesizing by means of an amplification reaction a mutagenized single strand of DNA comprising said primers in the presence of a DNA polymerase, a DNA ligase and a flap endonuclease; andc) digesting the non-mutagenized strands of said DNA molecule with a selection enzyme to produce a DNA product.2. The method of claim 1 , further comprising transforming a host cell with said DNA product in c).3. The method of claim 1 , wherein said DNA polymerase is a thermostable DNA polymerase.4Pyrolobus furmarius. The method of claim 3 , wherein said thermostable DNA polymerase is selected from the group consisting of: Taq DNA polymerase claim 3 , Pfu DNA polymerase claim 3 , Tma DNA polymerase claim 3 , Tli DNA polymerase claim 3 , KOD DNA polymerase claim 3 , JDF-3 DNA polymerase claim 3 , PGB-D DNA polymerase claim 3 , Tgo DNA polymerase and DNA polymerase.5. The method of claim 1 , wherein said DNA ligase is a thermostable DNA ligase.6Thermus filiformisRhodothermus marinusThermus scotoductusBacillus stearothermophilus. The method of claim 5 , wherein said thermostable DNA ...

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Номер записи: 73
16-05-2013 дата публикации

USE OF DNAZYMES FOR ANALYSIS OF AN RNA SAMPLE

Номер: US20130123129A1
Автор: Ach Robert A., Zeiner Gusti
Принадлежит: AGILENT TECHNOLOGIES, INC.

Provided herein is method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in the initial sample, thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage. 1. A method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in said initial sample , thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′ ,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage.2. The method of claim 1 , wherein said DNAzymes are 10-23 DNAzymes.3. The method of claim 1 , wherein contacting is done by cycling through denaturation and renaturation temperatures to maximize cleavage by said DNAzyme.4. The method of claim 1 , wherein said set of DNAzymes comprises at least 100 different DNAzymes that specifically target different RNAs.5. The method of claim 1 , further comprising ligating a first adaptor onto the 3′ ends of at least some of said cleaved RNA fragments using a 2′ claim 1 ,3′-cyclic phosphate-specific RNA ligase claim 1 , thereby producing a ligated sample comprising ligation products.6. The method of claim 5 , wherein said first adaptor comprises a 5′-phosphate or 5′-hydroxyl and said ligase is a eukarytic tRNA ligase.7. The method of claim 5 , wherein said first adaptor comprises a 5′-hydroxyl and said ligase is an RtcB ligase.8. The method of claim 5 , wherein said first adaptor is labeled claim 5 , and the method produces a labeled RNA sample.9. The method of claim 8 , wherein said method further comprises: a) hybridizing said labeled RNA sample to an array; b) reading said ...

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Номер записи: 74
23-05-2013 дата публикации

PLASMA TORCH WITH MULTIPLE INLETS FOR GUIDING COOLING GAS

Номер: US20130127324A1
Автор: KENT Sean M., NIELSEN Lars, PUGSLEY Benjamin J., STEVENSON Hugh Charles
Принадлежит: AGILENT TECHNOLOGIES, INC

A plasma torch comprises: a glass inner tube comprising an outlet where a plasma is formed; a glass outer tube comprising at least three inlets for receiving a cooling gas and distributing the cooling gas between the glass outer tube and the glass inner tube; and a cartridge housing comprising a gas receiving inlet, the glass outer tube being in fluid communication with the gas receiving inlet. Any two of the at least three inlets are radially offset by fewer than 180°. 1. A plasma torch , comprising:a glass inner tube comprising an outlet where a plasma is formed;a glass outer tube comprising at least three inlets for receiving a cooling gas and distributing the cooling gas between the glass outer tube and the glass inner tube; anda cartridge housing comprising a gas receiving inlet, the glass outer tube being in fluid communication with the gas receiving inlet, wherein any two of the at least three inlets are radially offset by fewer than 180°.2. A plasma torch as claimed in claim 1 , wherein the glass outer tube is disposed concentrically around the glass inner tube.3. A plasma torch as claimed in claim 2 , wherein the cartridge housing is disposed concentrically around the glass outer tube.4. A plasma torch as claimed in claim 1 , wherein the glass inner tube and the glass outer tube each comprise a quartz glass material.5. A plasma torch as claimed in claim 1 , wherein the inlets for receiving the cooling gas are disposed at substantially equal intervals around a circumference of the glass outer tube.6. A plasma torch as claimed in claim 1 , wherein the inlets for receiving the cooling gas are disposed at intervals of 120° around the glass outer tube.7. A plasma torch as claimed in claim 1 , wherein the cooling gas is substantially evenly distributed around the glass inner tube.8. A plasma torch as claimed in claim 1 , wherein the cooling gas flows around a plenum between the cartridge housing and the glass outer tube.9. A cartridge comprising the plasma torch ...

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Номер записи: 75
30-05-2013 дата публикации

FITTING ELEMENT WITH HYDRAULIC GRIP FORCE ELEMENT

Номер: US20130134082A1
Автор: Dehmer Bernhard
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fitting element (), in particular for an HPLC application (), is configured for providing a fluidic coupling of a tubing () to a fluidic device (). The fitting element () comprises a gripping piece () to exert—upon coupling of the tubing () to the fluidic device ()—a grip force (G) between the fitting element () and the tubing (). The gripping piece () comprises a hydraulic element () configured to transform an axial force (S) into a hydraulic pressure (P) within the hydraulic element (). The hydraulic pressure (P) in the hydraulic element () causes the grip force (G). 110010102103100. A fitting element () , in particular for an HPLC application () , configured for providing a fluidic coupling of a tubing () to a fluidic device () , the fitting element () comprising{'b': 108', '102', '103', '100', '102, 'a gripping piece () configured to exert—upon coupling of the tubing () to the fluidic device ()—a grip force (G) between the fitting element () and the tubing (), and'}{'b': 108', '170', '170, 'wherein the gripping piece () comprises a hydraulic element () configured to transform an axial force (S) into a hydraulic pressure (P) within the hydraulic element (),'}{'b': '170', 'the hydraulic pressure (P) in the hydraulic element () causes the grip force (G).'}2100170. The fitting element () of or any of the above claims claim 1 , wherein the hydraulic element () is an isotropic hydraulic element.3100. The fitting element () of the preceding claim claim 1 , comprising at least one of:the isotropic hydraulic element is configured to transforms an applied force into an isotropic pressure within the hydraulic element;the isotropic hydraulic element is configured to transforms an applied force into an isotropic pressure within the hydraulic element, at least after a given time period or at a given time constant;the isotropic hydraulic element is configured so that pressure at a boundary surface of the hydraulic element is substantially equal;the isotropic hydraulic ...

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Номер записи: 76
30-05-2013 дата публикации

TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY WITH CONTROL OF INJECTION IN RELATION TO A STATE OF THE SECOND DIMENSION CHROMATOGRAPH

Номер: US20130134095A1
Автор: Anderer Herbert, Witt Klaus
Принадлежит: AGILENT TECHNOLOGIES, INC.

A two-dimensional liquid chromatography in a system () comprises a first liquid chromatograph () coupled with a second liquid chromatograph (). An injection event of injecting an output of the first liquid chromatograph () into the second liquid chromatograph () is controlled () in relation to a state () of the second liquid chromatograph (). for publication 1. A method of providing two-dimensional liquid chromatography in a system comprising a first liquid chromatograph coupled with a second liquid chromatograph , the method comprising:controlling an injection event of injecting an output of the first liquid chromatograph into the second liquid chromatograph in relation to a state of the second liquid chromatograph.2. The method of claim 1 , wherein the second liquid chromatograph comprises a reciprocating pump claim 1 , the reciprocating pump is a dual pump having a primary piston and a secondary piston claim 1 , the primary piston is configured to intake fluid and to supply the fluid to the secondary piston claim 1 , the secondary piston is configured to output the fluid under pressure claim 1 , 15 and the state is defined by at least one of: □ at least one of a moving direction and a position of the secondary piston claim 1 , □ a cycle wherein the primary piston does not supply fluid to the secondary piston.3. The method of claim 1 , wherein the second liquid chromatograph is operated in a gradient mode claim 1 , wherein a composition of a solvent mixture is varied over time claim 1 , and the solvent mixture provides a mobile phase for transporting the injected output of the first liquid chromatograph.4. The method of claim 1 , wherein the second liquid chromatograph comprises a first reciprocating pump having a first piston reciprocating in the first reciprocating pump claim 1 , and a second reciprocating pump having a second piston reciprocating in the second reciprocating pump claim 1 , the method comprising:controlling the injection event in relation to the ...

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Номер записи: 77
30-05-2013 дата публикации

QUANTITATIVE PCR-BASED METHOD TO PREDICT THE EFFICIENCY OF TARGET ENRICHMENT FOR NEXT-GENERATION SEQUENCING USING REPETITIVE DNA ELEMENTS (LINES/SINES) AS NEGATIVE CONTROLS

Номер: US20130137582A1
Автор: Happe Scott, Ong Joseph Hoang Hai
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for determining an efficiency of target enrichment from a DNA library, includes: adding a negative control sequence and a positive control sequence to the DNA library, or picking a negative control sequence and/or a positive control sequence from the library; determining a pre-capture amount of the negative control sequence and a pre-capture amount of the positive control sequence; performing enrichment of a target sequence from the DNA library using a bait sequence to produce a post-capture library; determining a post-capture amount of the negative control sequence and a post-capture amount of the positive control sequence in the post-capture library; and determining the efficiency of the target enrichment, based on the post-capture amount of the positive control sequence, the post-capture amount of the negative control sequence, the pre-capture amount of the positive control sequence, and the pre-capture amount of the negative control sequence. 1. A method for determining an efficiency of target enrichment from a DNA library , comprising:adding a negative control sequence and/or a positive control sequence to the DNA library, or picking a negative control sequence and/or a positive control sequence from the DNA library;determining a pre-capture amount of the negative control sequence and a pre-capture amount of the positive control sequence in the DNA library;performing enrichment of a target sequence from the DNA library using at least one bait sequence to produce a post-capture library;determining a post-capture amount of the negative control sequence and a post-capture amount of the positive control sequence in the post-capture library; and based on a ratio of the post-capture amount of the positive control sequence over the post-capture amount of the negative control sequence, or', 'based on comparing (i) a first ratio of the pre-capture amount of the positive control sequence and the pre-capture amount of the negative control sequence, and (ii) a ...

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Номер записи: 78
30-05-2013 дата публикации

NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS

Номер: US20130137861A1
Автор: Lackey Jeremy, Leproust Emily Marine
Принадлежит: AGILENT TECHNOLOGIES, INC.

A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: 1. A reagent for oligonucleotide synthesis or purification , wherein the reagent has a structure of:{'br': None, 'X—C-L-H\u2003\u2003(Formula A)'}whereinX is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate;{'sub': a', 'b', 'a', '1', '6', '1', '6', 'b, 'C is a direct bond or a cleavable adaptor wherein the cleavable adaptor is represented by —C-C—, wherein Cis connected to X and is a direct bond, hydrocarbyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, a nucleoside, each of which is optionally substituted with one to two substituents selected from halo, hydroxyl, (C-C) alkoxy, (C-C) alkyl, amino or alklyamino; Cis a direct bond, a silanyl group, a trityl group, or a vicinyl alcohol group;'}{'sub': 6', '12', '1', '6, 'L is a hydrocarbyl chain which may be optionally substituted with one to four substituent groups independently selected from the group consisting of 5-to 9-membered heteroaryl, 4- to 9-membered heterocyclyl, amino, ether, carboxyl, carbamoyl, (C-C)aryl, —O—R″, —O—CO—R″, —NR′—R″, —NR′-CO—R″, —CO—NR′R″, —CO—R″, —CN, halogen, or a combination thereof, wherein R′ and R″ are independently H or (C-C)hydrocarbyl; or'}{'sub': a', 'b', 'c', 'd', 'e', '1', '6, 'L is a hydrocarbyl chain interspersed with other atoms, as represented by —(CHR′)—W—(CHR′)—V—(CHR′)—, wherein W and V are independently —O—, —S—, or —NR′—; R′ is H or (C-C)alkyl; and a, b, c, d, and e are independently an integer from 0 to 10; and'}H is a terminal alkyne or an activated cyclooctyne.2. The reagent of claim 1 , wherein H is the activated cyclooctyne group.3. The reagent of claim 1 , wherein C is represented by —C-C— claim 1 , wherein Cis connected to X and is a direct bond claim 1 , (C-C)hydrocarbyl claim 1 , (C-C)aryl claim 1 , 5- to 12-membered heteroaryl claim 1 , (C-C)cycloalkyl claim 1 , 4- to 12-membered heterocyclyl claim 1 , a nucleoside claim 1 , each of ...

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Номер записи: 79
30-05-2013 дата публикации

Method for predistorting signals for non-linear components in the presence of long term memory effects

Номер: US20130138416A1
Автор: Jan Verspecht
Принадлежит: AGILENT TECHNOLOGIES INC

A method and system for predistorting signals provides a test signal to model a non-linear component. Model kernels representative of static and dynamic parts of the model are extracted from an output of the non-linear component responsive to the test signal. The dynamic part represents memory effects of the non-linear component. The model kernels are then used to calculate an inverse memory model component model. An input signal is predistorted using the inverse memory model.

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Номер записи: 80
27-06-2013 дата публикации

DATA ACQUISITION MODES FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY

Номер: US20130161506A1
Автор: UGAROV MICHAEL
Принадлежит: AGILENT TECHNOLOGIES, INC.

Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition. 1. A method for acquiring spectrometric data from ions , the method comprising:injecting a plurality of ion packets sequentially into an ion mobility (IM) drift tube at a multiplexed injection rate, such that at least two ion packets are present in the IM drift tube at the same time;separating ions in each ion packet according to IM as the ions drift through the IM drift tube;transmitting the ion packets into a pulser of a time-of-flight (TOF) mass spectrometer;extracting a plurality of new ion packets sequentially from the pulser into a flight tube of the TOF mass spectrometer, wherein extraction is performed at a multiplexed extraction rate such that more than one extracted ion packet is produced from the same ion packet transmitted into the pulser, and at least two extracted ion packets are present in the flight tube at the same time;separating ions in each extracted ion packet according to TOF as the ions drift through the flight tube;detecting ions as the ions arrive at a detector from the flight tube; andbefore detecting the ions, selecting ions only of a specific m/z range, wherein each ion packet in the flight tube comprises ions of the same selected m/z range as the ions of the other ion packets, and overlap between sequential ion packets in the flight tube is minimized.2. The method of claim 1 , wherein the specific m/z range has a width ranging ...

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Номер записи: 81
27-06-2013 дата публикации

ADJUSTABLE APERTURE DEVICE WITH INTEGRAL APERTURE HOLES

Номер: US20130161517A1
Автор: Steinke Armin
Принадлежит: AGILENT TECHNOLOGIES, INC.

An adjustable aperture device for an electromagnetic radiation detecting apparatus includes a position adjustment body configured for adjusting a position of a selected aperture hole of multiple selectable aperture holes, where electromagnetic radiation propagates through the selected aperture hole. The adjustable aperture device further includes a guide unit configured for guiding the position adjustment body along a predefined guide direction, and an aperture body defining the aperture holes and including multiple engagement sections, where the adjustment body is engagable in a selectable one of the engagement sections to thereby select the selected aperture hole. The adjustable aperture device further includes a pre-loading element configured for pre-loading the position adjustment body towards the aperture body, and a drive unit configured for driving the aperture body to move so that the position adjustment body is engaged in a respective one of the plurality of engagement sections. 1. Adjustable aperture device for an electromagnetic radiation detecting apparatus , the aperture device comprising:a position adjustment body configured for adjusting a position of a selected aperture hole of a plurality of selectable aperture holes, wherein electromagnetic radiation is to propagate through the selected aperture hole;a guide unit configured for guiding the position adjustment body along a predefined guide direction;an aperture body defining the plurality of aperture holes and comprising a plurality of engagement sections, wherein the adjustment body is engagable in a selectable one of the plurality of engagement sections to thereby select the selected aperture hole from the plurality of selectable aperture holes;a pre-loading element configured for pre-loading the position adjustment body towards the aperture body; anda drive unit configured for driving the aperture body to move so that the position adjustment body is engaged in a respective one of the plurality of ...

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Номер записи: 82
04-07-2013 дата публикации

DETECTING RESPONSES OF MICRO-ELECTROMECHANICAL SYSTEM (MEMS) RESONATOR DEVICE

Номер: US20130169341A1
Автор: Ducatteau Damien, LEGRAND Bernard, TANBAKUCHI HASSAN, Theron Didier
Принадлежит: AGILENT TECHNOLOGIES, INC.

A system for detecting responses of a MEMS resonator device includes first and second signal sources, a signal divider and a frequency mixer. The first signal source provides a first signal and the second signal source provides a second signal that electrostatically drives the MEMS resonator device, causing mechanical vibration. The signal divider divides the first signal into a probe signal and a local oscillator (LO) signal, the probe signal being applied to the MEMS resonator device and reflected by a capacitance of the MEMS resonator device. A reflection coefficient is modulated onto the reflected probe signal at the mechanical resonance frequency by variations in the capacitance induced by the mechanical vibration of the MEMS resonator device. The frequency mixer mixes the reflected probe signal and the LO signal and outputs an intermediate frequency (IF) signal, which represents modulation of the reflection coefficient, providing an image of the mechanical vibration. 1. A system for detecting responses of a micro-electromechanical system (MEMS) resonator device , the system comprising:a first signal source configured to provide a first signal having a first frequency;a second signal source configured to provide a second signal having a second frequency, the second signal electrostatically driving the MEMS resonator device at approximately a mechanical resonance frequency, causing mechanical vibration of the MEMS resonator device;a signal divider configured to divide the first signal into a probe signal and a local oscillator (LO) signal, the probe signal being applied to the MEMS resonator device and reflected by a capacitance of the MEMS resonator device to provide a reflected probe signal, wherein a reflection coefficient is modulated onto the reflected probe signal at the mechanical resonance frequency by variations in the capacitance induced by the mechanical vibration of the MEMS resonator device; anda mixer configured to mix the reflected probe signal ...

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Номер записи: 83
04-07-2013 дата публикации

OPTICAL COHERENT RECEIVER WITH LOCAL OSCILLATOR LASER HAVING HYBRID CAVITY

Номер: US20130170843A1
Автор: Baney Douglas
Принадлежит: AGILENT TECHNOLOGIES, INC.

A coherent optical receiver includes a local oscillator (LO) laser configured to provide an LO signal. The LO laser includes a hybrid external cavity and an active gain medium within the hybrid external cavity, where the LO laser is defined between a first optical reflector on a chip including the active gain medium and a second optical reflector not on the chip. 1. A coherent optical receiver , comprising:a local oscillator (LO) laser configured to provide an LO signal, the LO laser comprising a hybrid cavity and an active gain medium within the hybrid cavity, the LO laser being defined between an interior first optical reflector on a chip including the active gain medium and an external second optical reflector not on the chip.2. The coherent optical receiver of claim 1 , further comprising:an optical coupling system on the chip configured to add an input optical signal and the LO signal from the LO laser to provide a plurality of combined optical signals; anda plurality of photodetectors on the chip configured to detect the plurality of combined optical signals, respectively.3. The coherent optical receiver of claim 1 , wherein the second optical reflector comprises one of a band pass reflective mirror claim 1 , a broadband mirror or a diffraction grating.4. The coherent optical receiver of claim 1 , wherein the second optical reflector is tunable.5. The coherent optical receiver of claim 1 , wherein the LO laser further comprises:a beam directing element configured to focus optical signals reflected from the second optical reflector into a waveguide coupled to the active gain medium within the hybrid cavity.6. The coherent optical receiver of claim 5 , wherein the beam directing element is a collimating lens.7. The coherent optical receiver of claim 5 , wherein the LO laser further comprises:a phase controller configured to enable phase adjustment in the hybrid cavity;an optical isolation section formed on the chip between the first optical reflector and the ...

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Номер записи: 84
11-07-2013 дата публикации

RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS

Номер: US20130175440A1
Автор: Perelman Gershon, Ristroph Trygve
Принадлежит: AGILENT TECHNOLOGIES, INC.

Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. 1. An ion guide , comprising:a plurality of first electrodes disposed about an axis;a first opening at a first end of the plurality of first electrodes;a second opening at a second end of the plurality of first electrodes;a substrate comprising a plurality of second electrodes disposed thereover, the substrate being disposed substantially orthogonally to the second opening and comprising a third opening that is substantially aligned with the second opening; andmeans for applying a radio frequency (RF) voltage between adjacent pairs of the first electrodes, and between adjacent pairs of the second electrodes, wherein the RF voltage creates an ion confining electrodynamic field in a region between the rods and between the electrodes; andmeans for applying a direct current (DC) voltage drop between the first opening and the second opening.2. An ion guide as claimed in claim 1 , wherein the first opening has a first area claim 1 , the second opening has a second area claim 1 , and the first area is greater than the second area.3. An ion guide as claimed in claim 2 , wherein the third opening has a third area claim 2 , and the third area is substantially identical to the second area.4. An ion guide as claimed in claim 1 , wherein the first electrodes are rods each having a first end and a second end remote from the first end claim 1 , the first opening being formed by the first ends claim 1 , and the second opening being formed by the second ends.5. An ion guide as claimed in claim 1 , wherein the second electrodes are substantially circular in cross section.6. An ion guide as claimed in claim 1 , wherein the second electrodes are substantially parallel to each other.7. An on guide as ...

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Номер записи: 85
11-07-2013 дата публикации

INDUCTIVELY COUPLED PLASMA MS/MS MASS ANALYZER

Номер: US20130175442A1
Автор: KITAMOTO JUN, KUWABARA TAKEO, YAMADA NORIYUKI
Принадлежит: AGILENT TECHNOLOGIES, INC.

An inductively coupled plasma MS/MS mass analyzer (ICP-MS/MS) may include a first vacuum chamber which draws plasma containing an ionized sample into vacuum, a second vacuum chamber which includes a device or means which extracts and guides ions as an ion beam from the ions output from the first vacuum chamber, a third vacuum chamber which has a first ion optical separation device or means, a fourth vacuum chamber which has a cell into which reaction gas is introduced, and a fifth vacuum chamber which has a second optical separation device or means and a detector, wherein the second vacuum chamber and third vacuum chamber are individually evacuated. 1. An inductively coupled plasma MS/MS mass analyzer , comprising:a first vacuum chamber for drawing plasma containing an ionized sample produced at atmospheric pressure into vacuum and for outputting the plasma;a second vacuum chamber comprising a device for extracting ions containing an analysis target as a beam from the plasma outputted from the first vacuum chamber and for converging and guiding the beam;a third vacuum chamber connected to the second vacuum chamber and comprising a first ion optical separation device;a fourth vacuum chamber connected to the third vacuum chamber and comprising a cell into which reaction gas is introduced; anda fifth vacuum chamber connected to the fourth vacuum chamber and comprising a second optical separation device and a detector,wherein said second vacuum chamber and said third vacuum chamber are individually pumped.2. The inductively coupled plasma MS/MS mass analyzer according to claim 1 , wherein said ion optical separation device separates ions according to mass-to-charge ratio.3. The inductively coupled plasma MS/MS mass analyzer according to claim 1 , wherein said second vacuum chamber is maintained at a pressure of 0.5 Pa or below claim 1 , and said third vacuum chamber is maintained at a pressure of 1×10Pa to 2×10Pa.4. The inductively coupled plasma MS/MS mass analyzer ...

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Номер записи: 86
11-07-2013 дата публикации

NUCLEAR MAGNETIC RESONANCE PROBE COMPRISING INFRARED REFLECTION PATCHES

Номер: US20130178366A1
Автор: WITHERS Richard S.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A nuclear magnetic resonance (NMR) probe comprises a substrate, a probe coil formed on the substrate and comprising a superconducting material, and a plurality of infrared (IR) reflection patches formed on the substrate around the probe coil. 1. A nuclear magnetic resonance (NMR) probe , comprising:a substrate;a probe coil formed over the substrate and comprising a superconducting material; anda plurality of patches formed over the substrate and around the probe coil, wherein each of the patches is configured to reflect infrared (IR) radiation from a sample tube within the NMR probe.2. The NMR probe of claim 1 , wherein each of the patches comprises a layer of normal metal surrounded by an exposed portion of the substrate.3. The NMR probe of claim 2 , wherein the layer of normal metal is formed over a layer of the superconducting material surrounded by the exposed portion of the substrate.4. The NMR probe of claim 1 , wherein the NMR probe coil comprises a layer disposed in a spiral or interdigital configuration over the substrate.5. The NMR probe of claim 4 , wherein the substrate comprises sapphire.6. The NMR probe coil of claim 4 , wherein the layer comprises yttrium barium copper oxide (YBCO).7. The NMR probe coil of claim 1 , wherein each of the plurality of patches comprises a layer of gold surrounded by an etched portion of the substrate.8. The NMR probe of claim 2 , wherein the patches have rectangular shapes.9. The NMR probe of claim 1 , wherein each of the patches has a maximum line width less than or equal to approximately 12 microns.10. The NMR probe of claim 1 , wherein the plurality of patches provides a filling factor of approximately 60% to approximately 70%.11. The NMR probe of claim 1 , wherein the patches surround an outer perimeter of the probe coil and fill a majority of an enclosed center area of the probe coil.12. The NMR probe of claim 1 , further comprising:a center tube configured to receive the sample tube within an annular space;a gas ...

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Номер записи: 87
18-07-2013 дата публикации

SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS

Номер: US20130180404A1
Автор: BERGER Terry A., Fogelman Kimber D., Wikfors Edwin E.
Принадлежит: AGILENT TECHNOLOGIES, INC.

An apparatus and process to effectively create an active drain for high and low pressure gas-liquid separator. The invention accomplishes a deterministic drainage rate of variable volume and viscosity liquid fractions from the separator. The mechanisms and methods thereof create a flow path from the separator that dramatically favors controlled liquid flow over a wide range of flow rates and viscosities while restricting gas flow. The invention is a superior method of drainage over conventional systems that employ pressure, vacuum, isolation valves and/or passive flow restrictors to achieve drainage of the separators. The embodiments are primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE). An advantage of one embodiment allows the economical conversion of typical HPLC systems to state of-the-art supercritical fluid chromatography (SFC) systems with minimal modification to system components. 1. A method comprising:transferring, by positive displacement, discrete flow segments from a liquid-enriched exit flow port of a gas-liquid separator between an inlet and an outlet such that the discrete flow segments are not in simultaneous communication at both the inlet and the outlet; andtransferring the discrete flow segments at a rate unaffected by positive or negative pressure gradients between the inlet and the outlet, thereby providing deterministic drainage rates from the gas-liquid separator.2. The method claim 1 , further comprising:actively generating at least one of positive and negative pressure gradients in e a flowstream to promote predictable flow of the discrete flow segments to a collection system.3. The method of claim 1 , wherein the transferring the discrete flow segments is performed using a positive displacement pump.4. The method of claim 1 , further comprising:restricting other means of flow from the exit flow port.5. The process of claim 1 , further comprising:controlling ...

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Номер записи: 88
01-08-2013 дата публикации

LOW NOISE BACK PRESSURE REGULATOR FOR SUPERCRITICAL FLUID CHROMATOGRAPHY

Номер: US20130192698A1
Автор: BERGER Terry A., CASALE Michael, COLGATE Samuel
Принадлежит: AGILENT TECHNOLOGIES, INC.

A drive mechanism for back pressure regulator used in liquid chromatography, supercritical fluid chromatography, or supercritical fluid extraction allows very fine automated control over a very wide range of pressures by combining a linear actuator compressing a spring, pushing a pin. The nozzle assembly of the regulator comprises a flow through chamber containing a diaphragm and a seat, in which the pin pushes the diaphragm against the seat, together with an upstream pressure sensor and electronic feedback control to the motor of the actuator. The BPR of the embodiments exhibits high pressure stability and extremely low pressure noise, even at moderate to high pressures. The exemplary BPR can be use at either constant pressure or to generate pressure programs where the pressure is varied versus time. Further, the nozzle assembly has a field-replaceable head, requiring no mechanical adjustment on replacement. 1a linear actuator comprising a motor applying a force to a spring, wherein said spring applies a second force to a pin;a nozzle assembly comprising a flow-through chamber with a dimpled diaphragm against a seat of a nozzle body;an inlet tube for transferring a mobile phase into the nozzle assembly; andan outlet tube connected to a shaped orifice which receives the dimpled diaphragm when actuated by the force from the pin.. A drive mechanism for a back pressure regulator, comprising: None.The present invention relates to methods and systems for controlling pressure of a mobile phase flowstream within chromatography and extraction systems, such as liquid chromatography, supercritical chromatography, and supercritical extraction systems, with a pressure regulator.Supercritical fluid chromatography (SFC) is a separation technique similar to high performance liquid chromatography (HPLC), except one of the fluids used as a solvent is a highly compressible liquefied gas. Supercritical fluid extraction (SFE) is a related technique but with somewhat lower requirements ...

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Номер записи: 89
01-08-2013 дата публикации

ION SOURCE FOR MASS SPECTROMETERS

Номер: US20130193318A1
Автор: HANSEN Stuart C., LAND Adrian
Принадлежит: AGILENT TECHNOLOGIES, INC.

Ion sources for use in mass spectrometry (MS) systems are described. The ion sources each comprise an ion funnel and an ionization source configured to ionize neutral analyte molecules. 1. An ion source , comprising:an ion funnel comprising a first opening at a first end and a second opening at a second end, the first opening configured to receive neutral analyte molecules; andan ionization device configured to ionize the neutral analyte molecules in the ion funnel.2. An ion source as claimed in claim 1 , further comprising an inlet capillary configured to deliver the neutral analyte molecules to the first opening claim 1 ,3. An ion source as claimed in claim 2 , wherein the inlet capillary is in fluid communication with a gas chromatograph.4. An ion source as claimed in claim 1 , wherein the ionization device comprises one of: an electromagnetic radiation source and an electron source.5. An ion source as claimed in claim 4 , wherein the electromagnetic radiation source comprises a vacuum ultraviolet (VUV) radiation source.6. An ion source as claimed in claim 5 , wherein the VUV source comprises one of:a microplasma VUV source, an excimer VUV source, a direct current (DC) excited gas discharge source, an alternating current (AC) excited gas discharge source, or a laser source.7. An ion source as claimed in claim 5 , wherein the VUV source is positioned so that photons from the VUV source interact with the neutral analyte molecules inside the ion funnel.8. An ion source as claimed in claim 7 , wherein the VUV source is a first VUV source claim 7 , and the ion source further comprises a second VUV source claim 7 , the first VUV source and the second VUV source each being positioned at an angle relative to an axis of symmetry of the ion funnel.9. An ion source as claimed in claim 8 , further comprising a third VUV source and a fourth VUV source each positioned so that photons from the second VUV source claim 8 , the third VUV source and the fourth VUV source interact ...

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Номер записи: 90
01-08-2013 дата публикации

COMPACT, ULTRA-BROADBAND ANTENNA WITH DOUGHNUT-LIKE RADIATION PATTERN

Номер: US20130194160A1
Автор: LEE Gregory S.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A compact, ultra-broadband antenna with doughnut-like radiation pattern is provided as including a first assembly having first and second ends; a second assembly having first and second ends, the first and second ends each configured to have a substantially hemispherical shape; and a cable configured to extend through the first and second assemblies and out each of the first and second ends. 1. An antenna comprising:a first assembly having first and second ends;a second assembly having first and second ends.the first and second ends each configured to have a substantially hemispherical shape; anda cable configured, to extend through the first and second assemblies.2. The antenna of claim 1 , wherein the cable is comprised of inner and outer conductors.3. The antenna of claim 2 , wherein only the outer conductor is electrically connected to the first assembly.4. The antenna of claim 3 , wherein both the inner and outer conductors are electrically connected to the second assembly.5. The antenna of claim 3 , wherein only the inner conductor is electrically connected to the second assembly.6. The antenna of claim 2 , wherein the first and second assemblies are disposed claim 2 , separate from each other claim 2 , the cable extends in a gap between the first and second assemblies claim 2 , and the outer conductor is removed claim 2 , from a portion of the cable in the gap.7. The antenna of claim 6 , wherein the inner conductor is exposed at the portion of the cable where the outer conductor is removed.8. The antenna of claim 2 , wherein the first and second assemblies are disposed separate from each other with a gap in between claim 2 , and the outer conductor is removed from the cable in the gap and from the cable extending through and out of the second assembly.9. The antenna of claim 2 , wherein the inner and outer conductors are shorted together at a terminal end outside the second assembly.10. The antenna of claim 1 , wherein the cable extends out each of the first ...

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Номер записи: 91
01-08-2013 дата публикации

PHASE-CONTINUOUS TUNABLE LASER

Номер: US20130195129A1
Автор: COLEMAN Christopher L., Vanwiggeren Gregory Douglas
Принадлежит: AGILENT TECHNOLOGIES, INC.

A tunable laser comprises a first tuner configured to select an emission wavelength of the laser a second tuner configured to adjust a cavity mode of the laser by modifying the cavity optical path length. The second tuner is constrained by a finite tuning range. The tunable laser also comprises a controller configured to control the first and second tuners to select the emission wavelength and adjust the cavity mode in synchronization to perform phase-continuous tuning across a range larger than supported by the finite tuning range of the second tuner. 1. A tunable laser , comprising:a first tuner configured to select an emission wavelength of the laser;a second tuner configured to adjust a cavity mode of the laser by modifying the cavity optical path length, wherein the second tuner is constrained by a finite tuning range; anda controller configured to control the first and second tuners to select the emission wavelength and adjust the cavity mode in synchronization to perform phase-continuous tuning across a range larger than supported by the finite tuning range of the second tuner.2. The tunable laser of claim 1 , wherein the first tuner comprises a mechanically tuned filter comprising at least one of a diffraction grating claim 1 , a mirror claim 1 , and a prism.3. The tunable laser of claim 2 , further comprising a direct drive motor configured to rotate the diffraction gating claim 2 , mirror claim 2 , or prism about its own center.4. The tunable laser of claim 1 , wherein the second tuner comprises a polarization controller that linearly advances a phase of an input wavelength from 0 to 2π in successive drive periods of sinusoidal drive voltages.5. The tunable laser of claim 4 , wherein the polarization controller comprises waveplates and at least one of the waveplates is rotated about an axis to linearly advance the phase of the input wavelength from 0 to 2π in successive drive periods of the sinusoidal drive voltages.6. The tunable laser of claim 5 , ...

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Номер записи: 92
01-08-2013 дата публикации

System for measuring residual phase noise

Номер: US20130197848A1
Автор: Dara Sariaslani, Joel P. Dunsmore
Принадлежит: AGILENT TECHNOLOGIES INC

A system for measuring residual phase noise of a device under test (DUT) includes first and second signal sources, first and second receivers, and a processor. The first signal source generates a first signal to be input to the DUT as a stimulus signal and provides a second signal that is phase coherent with the first signal. The second signal source receives the second signal and generates a reference signal based on the second signal, which is phase coherent with the stimulus signal. The first receiver measures an output signal from the DUT responsive to the stimulus signal, and the second receiver measures the reference signal from the second signal source. The processor mathematically suppresses a carrier of the output signal by determining a difference between the measured output signal and the measured reference signal, and determines the residual phase noise of the DUT based on the difference.

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Номер записи: 93
08-08-2013 дата публикации

FERRULE CHUCK WITH SURFACE MICRO-GRIP

Номер: US20130199981A1
Автор: Dehmer Bernhard
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule. 1. A fitting for coupling a capillary to another component of a fluidic device , the fitting comprisinga ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component;a ferrule chuck configured for enclosing a back part of the capillary; anda housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule;a microstructure formed as multiple microprotrusions on at least a part of a surface of the ferrule chuck for generating, upon tightening the fitting at the other component, a form fit with the enclosed back part of the capillary over a contact area between the ferrule chuck and the capillary.2. The fitting according to claim 1 , wherein the microstructure comprises multiple microprotrusions protruding from a surface of the ferrule chuck.3. The fitting according to claim 1 , wherein the microprotrusions are randomly distributed over the surface of the ferrule chuck.4. The fitting according to claim 1 , wherein at least a part of the microprotrusions has a dimension (h) claim 1 , a which differs from a corresponding dimension (H) of at least a part of adjacent ones of the microprotrusions.5. The fitting according to claim 1 , wherein claim 1 , for at least a part of the microprotrusions claim 1 , a distance (d) between a pair of adjacent ones of the microprotrusions differs from a distance (D) between microprotrusions of other pairs of adjacent ...

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Номер записи: 94
08-08-2013 дата публикации

CHARGE CORRECTION FOR PIEZOELECTRIC ACTUATOR

Номер: US20130200751A1
Автор: SCHROEDER Dale W.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A system comprises a voltage source, a piezoelectric material arranged in a first current path between the voltage source and a first reference voltage, a capacitor arranged in a second current path between the voltage source and a second reference voltage, and a correction circuit configured to adjust the first reference voltage to increase or decrease the current in the first current path according to the current in the second current path. 1. A system , comprising:a voltage source;a piezoelectric material located in a first current path between the voltage source and a first reference voltage;a capacitor located in a second current path between the voltage source and a second reference voltage; and,a correction circuit configured to adjust the first reference voltage to increase or decrease a first current in the first current path according to a second current in the second current path.2. The system of claim 1 , wherein the first reference voltage is a virtual ground voltage and the second reference voltage is ground.3. The system of claim 1 , further comprising:a first current monitor located in the first current path and configured to detect a magnitude of the first current; anda second current monitor located in the second path and configured to detect a magnitude of the second current.4. The system of claim 3 , wherein the second current monitor amplifies the second current claim 3 , and the correction circuit adjusts the virtual ground voltage such that the first current approximates the amplified second current.5. The system of claim 3 , further comprising a controller configured to adjust a target capacitance of the piezoelectric material by changing a gain ratio of the first and second current monitors.6. The system of claim 4 , wherein the correction circuit comprises an amplifier that receives the first current and the amplified second current claim 4 , determines a difference between the first and second currents claim 4 , and adjusts the virtual ...

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Номер записи: 95
08-08-2013 дата публикации

METHOD OF GENERATING INTERFERENCE SIGNALS AND DEVICE TO CARRY OUT SUCH A METHOD

Номер: US20130202020A1
Автор: DIEZ Antonio Francisco Jurado, TORRECILLA Joaquin
Принадлежит: AGILENT TECHNOLOGIES, INC

A method for generating interference signals and a device to carry out said method, in which an interference signal () is added in a signal combination and separation network () with a desired signal () that carries a test message, the sum signal being sent to a device being tested (). The interference signal () is generated with a single source connected to a signal divider and conditioner block () that attenuates additional interference produced by the source of generation of interference signals (), while providing as many interference signals () as the device () under test has antennas (Rx, Rx/Tx), and in which each interference signal () is sent to a respective amplification and isolation block (), which adjusts the power level of the interference signal () and attenuates the reverse intermodulation products produced by the transmission of signals by the device () under test. 1. A method for generating interference signals used to generate an interference signal that is added in a signal combination and separation network with a desired signal that carries a test message , the sum signal being sent to a device being tested , provided with multiple signal reception and transmission/reception antennas , the method comprising:generating the interference signal by a single source of generation of interference signals, wherein the interference signal is connected to a signal divider and conditioner block that attenuates additional interference produced by the source of generation of interference signals, the signal divider and conditioner block providing at an output as many interference signals as the device under test has antennas;sending each interference signal obtained in the signal divider and conditioner block is to a respective amplification and isolation block, the amplification and isolation block adjusting a power level of the corresponding interference signal and attenuating the reverse intermodulation products produced by the transmission of signals by ...

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Номер записи: 96
15-08-2013 дата публикации

DIGITAL OSCILLOSCOPE COMPRISING MULTIPLE DATA ACQUISITION PATHWAYS

Номер: US20130207641A1
Автор: BOSS Marshall, FENDER Michael R., HOLCOMB Matthew S., LARSEN Kristopher A., PELELO Steven J., TIMM Daniel P.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A digital oscilloscope comprises a sampling unit configured to sample an input signal received from an oscilloscope probe to produce a first stream of digital samples, a first acquisition system configured to store and process the stream of digital samples to produce a first data set, a second acquisition system configured to store and process the first stream of digital samples independent of the first acquisition system to produce a second data set, and a display system configured to concurrently display the first data set in a first format and the second data set in a second format different from the first format. 1. A system , comprising:a sampling unit configured to sample an input signal received from an oscilloscope probe to produce a first stream of digital samples;a first acquisition system configured to store and process the first stream of digital samples to produce a first data set;a second acquisition system configured to store and process the first stream of digital samples independent of the first acquisition system to produce a. second data set; anda display system configured to concurrently display the first data set in a first format and the second data set in a second for different from the first format.2. The system of claim 1 , wherein the second acquisition system combines digital samples among the first stream of digital samples to produce a second stream of digital samples having a tower sampling rate that the first stream of digital samples.3. The system of claim 2 , wherein the second acquisition system comprises an accumulator configured to receive the first stream of digital samples claim 2 , accumulate a plurality of the digital samples during each of multiple successive intervals claim 2 , and combine the samples accumulated in each interval to produce the second stream of digital samples.4. The system of claim 1 , wherein the second acquisition system stores a squared value of each digital sample among the first stream of digital ...

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Номер записи: 97
29-08-2013 дата публикации

DOWNCONVERSION OF COMB SPECTRUM

Номер: US20130225110A1
Автор: KARLQUIST Richard K.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A downconverter mixes a first comb spectrum with a local oscillator signal to generate a second comb spectrum in a lower frequency range. The first comb spectrum comprises frequency components separated from each other according to a frequency spacing interval, and the LO signal has a frequency offset relative to the first comb spectrum, where the frequency offset is a rational fraction of the frequency spacing interval. The second comb spectrum comprises lower and upper sideband responses corresponding to respective lower and upper sideband signals of the first comb spectrum. The lower and upper sideband responses in the second comb spectrum can be distinguished from each other based on the frequency offset. 1. A method comprising:receiving a first comb spectrum comprising a plurality of frequency components separated from each other according to a frequency spacing interval;receiving a local oscillator (LO) signal having a frequency offset relative to the first comb spectrum, wherein the frequency offset is a rational fraction of the frequency spacing interval and is less than one;mixing the first comb spectrum with the LO signal to generate a second comb spectrum, wherein the second comb spectrum comprises lower and upper sideband responses corresponding to respective lower and upper sideband signals of the first comb spectrum; anddistinguishing between the lower and upper sideband responses in the second comb spectrum based on the frequency offset2. The method of claim 1 , further comprising generating a test comb spectrum to excite a device under test (DUT) claim 1 , and receiving the first comb spectrum as a response comb spectrum from the DUT.3. The method of claim 1 , further comprising generating a downconverted comb spectrum by recovering the lower and upper sideband responses from the second comb spectrum and rejecting harmonic responses included in the second comb spectrum.4. The method of claim 1 , wherein the frequency offset is M/N times the frequency ...

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Номер записи: 98
29-08-2013 дата публикации

Method of Determining Thermodynamic and Kinetic Parameters from Measured Off Rates

Номер: US20130225429A1
Автор: Curry Bo
Принадлежит: AGILENT TECHNOLOGIES, INC.

A method for measuring a property of a binding interaction between a capture agent and a binding partner for the capture agent is provided. In certain embodiments, this method comprises: a) contacting a population of particles that are linked to a capture agent with a substrate comprising a binding partner to produce capture agent/binding partner complexes, wherein the population of particles comprises first particles that are bound to a single molecule of the capture agent and second particles that are bound to two molecules of the capture agent; b) applying a force to the bound support, wherein the force is in a direction that separates the particles from the support; and c) separately measuring the forces required to disassociate the first particles and the second particles from their respective complexes. 1. A method for measuring a property of a binding interaction between a capture agent and a binding partner for said capture agent , comprising:a) contacting a population of particles that are linked to a capture agent with a substrate comprising a binding partner to produce capture agent/binding partner complexes, wherein said population of particles comprises first particles that are bound to a single molecule of said capture agent and second particles that are bound to two molecules of said capture agent;b) applying a force to the bound support, wherein said force is in a direction that separates said particles from said support;c) separately measuring the forces required to disassociate the first particles and the second particles from their respective complexes;d) calculating the off rates of said first particles and said second particles as a function of the applied force;e) calculating the off rates for said first particles in the absence of applied force from the dependence of off rates on the applied force; ande) calculating the on rates for binding said first particles and said second particles, using the respective off rates calculated in d) and e).2 ...

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Номер записи: 99
05-09-2013 дата публикации

BALANCED VOLTAGE VARIABLE CAPACITOR DEVICE

Номер: US20130229747A1
Автор: Finnigan James P.
Принадлежит: AGILENT TECHNOLOGIES, INC.

A variable capacitor device includes a stator and a rotor. The stator includes first and second stator plates separated by electrically insulating material. The rotor includes first and second rotor plates connected by a rod, the rotor being configured to move axially for adjusting alignment of the first rotor plate relative to the first stator plate and the second rotor plate relative to the second stator plate, respectively. The first stator plate and the first rotor plate form a first variable capacitor, and the second stator plate and the second rotor plate form a second variable capacitor connected in series with the first variable capacitor. A first capacitance of the first variable capacitor and a second capacitance of the second variable capacitor are simultaneously adjustable upon the axial movement of the rotor to provide an adjustable total capacitance of the variable capacitor device. 1. A variable capacitor device , comprising:a stator comprising a first stator plate and a second stator plate separated from the first stator plate by an electrically insulating material; anda rotor comprising a first rotor plate and a second rotor plate connected by a rod, the rotor being configured to move axially for adjusting alignment of the first rotor plate relative to the first stator plate and the second rotor plate relative to the second stator plate, respectively,wherein the first stator plate and the first rotor plate form a first variable capacitor, and the second stator plate and the second rotor plate form a second variable capacitor connected in series with the first variable capacitor, a first capacitance of the first variable capacitor and a second capacitance of the second variable capacitor being simultaneously adjustable upon the axial movement of the rotor to provide an adjustable total capacitance of the variable capacitor device.2. The variable capacitor device of claim 1 , wherein the rod connecting the first and second rotor plates comprises an ...

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Номер записи: 100