ELEMENT AND CUTTING TOOL FOR AGRICULTURAL MACHINERY AND AGRICULTURAL MACHINERY CORRESPONDING

Protein complexes of cellular networks underlying the development of cancer and other diseases

The present invention relates to protein complexes involved in cellular processes which have been shown to be critical for the development of various forms of cancer, component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complexes. The present invention also relates to methods for use of the complexes and their interacting proteins in, inter alia, screening, diagnosis, and therapy, as well as to methods of preparing the complexes.

Multifunctional mobile appliance

The invention is a multifunctional, mobile appliance capable of performing a variety of tasks safely, quietly, without pollution, and out of sight of its owner. Such tasks might include lawn mowing, fertilizing, and edging, floor vacuuming, waxing, and polishing, or rug shampooing. In its preferred implementation, the mobile unit 1 would obtain precise real time and position information using the Real Time Kinematic Global Positioning System. The user initially guides the appliance around the work-area perimeters. The device then uses this information to determine the full working area. Proximity detectors and impact sensors help the appliance avoid unexpected obstacles. The device is quiet enough to perform its task in the middle of the night while its owner is asleep, but can be programmed to work continuously or during any user-specified time interval. The small turning radius of the appliance allows it to follow intricate perimeters. In the instance of a mowing application, the cutting blades are surrounded by a cage that allows grass to enter, but excludes sticks, stones, fingers or toes. The mowing blade assembly can trim over the top of yard edging. The battery-powered device can recharge itself and a wireless link enables the appliance to communicate with its user and a user support network via the World Wide Web.

Curable material delivery device

An apparatus and method for introducing material into an injection site of a patient is disclosed. The device includes a cannula and a carrier. The cannula is inserted into an injection site of a patient. The carrier is connected to an injector containing a volume of material. Material may be pre-loaded into the carrier so that the material is delivered to a distal end of the carrier from the injector and the carrier is thus pre-loaded with material. A portion of the distal end of the pre-loaded carrier is inserted into the cannula and material is delivered to an injection site.

Multi-way sliding plug

The invention relates to a multi-way sliding plug (11), comprising a housing (13) and at least two plug contacts (40,50) of differing standards, which can be slid into the housing (13) into a passive position and out of the housing into an active position. Said plug contacts (40,50) each have a slide (47,57) with an operating head (15) and electrically conducting pins (41,43,45;51,53,55). The individual plug contacts (40,50) have three electrically conducting pins (41,43,45;51,53,55) on a common slider. At least two of said slides (47,57) are in a C-shape and arranged in opposition with the ends of the C-shape between the ends of the C-shape of the other slider (47,57).

Multiple socket

A socket has a plug board with first plug-in openings for appropriate pins of a plug of a first standard and with second plug-in openings for appropriate pins of a plug of a second standard. Provided in a spacing to the plug board are a first type of contact mounts for receiving plug pins of the first standard, and a second type of contact mounts for receiving plug pins of the second standard. Provided between the contact mounts and the plug board are protection elements which are movable out of a closed position in which the first and second plug-in openings are blocked, into an open position in which the plug-in openings are open. The protection elements are pretensioned into their respective closed positions by spring elements. The first and second protection elements are pretensioned into their respective end positions in different directions of movement by the spring elements.

Treatment of neurodegenerative diseases by the use of laptm4a

The invention relates to the use of a LAPTM4A-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the LAPTM4A-interacting molecule is preferably an inhibitor of LAPTM4A and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator, comprising the following steps: a. identifying of a LAPTM4A-interacting molecule by determining whether a given test compound is a LAPTM4A-interacting molecule, b. determining whether the LAPTM4A-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.

Method for in vitro amplification of circular dna

A method for generating and amplifying closed circular DNA having a specific sequence in vitro in a cell-free system is disclosed. Prior to the invention of this method, closed circular DNA could only be amplified in vivo in appropriate host cells. The essence of the method is the inclusion of a thermostable DNA ligase in a PCR reaction. This procedure is referred to as ligation-during-amplification (LDA), in which the fully extended DNA strands are ligated by the DNA ligase and used as templates for subsequent amplification. Closed circular DNA having a specific sequence can be selectively amplified exponentially by the use of two sequence-specific primers in the LDA reaction. In addition, one or more site-specific mutations can be introduced into a closed circular DNA by the use of one or more mutagenic primers in the LDA reaction. Various thermostable DNA polymerases and thermostable ligases can be used for LDA apmlification. Any primer position and orientation, either inward or outward, can be used in LDA amplification, as long as there is at least one primer complementary to each strand of the circular DNA. This method has applications in the areas of mutagenesis, cloning, DNA detection, DNA modification, genehunting, gene therapy, and cell-free DNA production.

Robot with a direct-drive system

Proposed is a robot (see the figure) which has a terminal member designed to hold end-effectors (33) and moved by two articulated-arm systems (1, 2) which at one one end form together the terminal member, the other ends being connected to the rotors of two drive motors (5). The stators of the motors are connected, in diametrically opposed configuration, to an upright (13) which is in turn connected to a baseplate (14). Located inside the articulated-arm system are drives for the spatial positioning of the end-effectors. These systems include suitable motors (19) which are rigidly connected to the baseplate (14). The robot is thus free to move about its main axis (A2) without being restricted by power or control lines.

Devices, systems and methods for bioimpendence measurement of cervical tissue and methods for diagnosis and treatment of human cervix

Featured are apparatuses (220) for measuring bioimpendence of tissues of the cervix, more specifically the mammalian cervix. Also featured are methods for examining the tissues of the cervix for clinical or diagnostic purposes such as during routine gynecological examinations to determine early onset of labor in pregnant patients or to assess such tissues for the presence of abnormalities such as cancerous lesions in both pregnant and non-pregnant women. Also featured are methods for treating onset of early or pre-term labor that embody such devices, apparatuses (220) and/or methods, where such systems preferably are configured to provide diagnostic and/or clinical information to further assist the diagnostician or clinician in diagnosing and/or examining pregnant or non-pregnant patients.

Multifunctional mobile appliance

The invention is a multifunctional, mobile appliance capable of performing a variety of tasks safely, quietly, without pollution, and out of sight of its owner. Such tasks might include lawn mowing, fertilizing, and edging, floor vacuuming, waxing, and polishing, or rug shampooing. In its preferred implementation, the mobile unit 1 would obtain precise real time and position information using the Real Time Kinematic Global Positioning System. The user initially guides the appliance around the work-area perimeters. The device then uses this information to determine the full working area. Proximity detectors and impact sensors help the appliance avoid unexpected obstacles. The device is quiet enough to perform its task in the middle of the night while its owner is asleep, but can be programmed to work continuously or during any user-specified time interval. The small turning radius of the appliance allows it to follow intricate perimeters. In the instance of a mowing application, the cutting blades are surrounded by a cage that allows grass to enter, but excludes sticks, stones, fingers or toes. The mowing blade assembly can trim over the top of yard edging. The battery-powered device can recharge itself and a wireless link enables the appliance to communicate with its user and a user support network via the World Wide Web.

Adapter plug

The invention relates to a three-pole adapter plug (11), comprising, on a first side, a safety plug (13) with two pins (31, 33) and two earth conductors (23,24), in particular a hybrid plug according to the standard CEE 7/7 with an additional contact sleeve (49.5) for a FR earth pin. On the second side, opposite to the first side the adapter has a socket (15) for at least one plug of British standard. A housing (41,43) for the adapter plug (11) forms a safety plug body (21). Contact sleeves (45.3, 47.3, 49.3) for such plugs to British Standards are arranged within the safety plug body (21). According to the invention, one of said earth conductors (23) of the safety plug (13) forms a contact sleeve (49.3) for the UK earth pin on the inner side thereof.

Multifunctional mobile appliance

The invention is a multifunctional, mobile appliance capable of performing a variety of tasks safely, quietly, without pollution, and out of sight of its owner. Such tasks might include lawn mowing, fertilizing, and edging, floor vacuuming, waxing, and polishing, or rug shampooing. In its preferred implementation, the mobile unit 1 would obtain precise real time and position information using the Real Time Kinematic Global Positioning System. The user initially guides the appliance around the work-area perimeters. The device then uses this information to determine the full working area. Proximity detectors and impact sensors help the appliance avoid unexpected obstacles. The device is quiet enough to perform its task in the middle of the night while its owner is asleep, but can be programmed to work continuously or during any user-specified time interval. The small turning radius of the appliance allows it to follow intricate perimeters. In the instance of a mowing application, the cutting blades are surrounded by a cage that allows grass to enter, but excludes sticks, stones, fingers or toes. The mowing blade assembly can trim over the top of yard edging. The battery-powered device can recharge itself and a wireless link enables the appliance to communicate with its user and a user support network via the World Wide Web.

Treatment of neurodegenerative diseases by the use of degs inhibitors

The present invention relates to the use of DEGS interacting molecules, especially DEGS inhibitors, for the preparation of a medicament for the treatment of neurodegenerative diseases, particularly Alzheimer's disease.

Pneumatic tube system

Curable material delivery device with a rotatable supply section

An apparatus and method for introducing material into an injection site of a patient is disclosed. The device includes a cannula (30) and a carrier (20). The cannula is inserted into an injection site of a patient. The carrier is connected to an injector containing a volume of material. Material may be pre-loaded into the carrier so that the material is delivered to a distal end of the carrier from the injector and the carrier is thus pre-loaded with material. A portion of the distal end of the preloaded carrier is inserted into the cannula and material is delivered to an injection site. The carrier comprises a supply section (120) operable to receive curable material, and an inner section (140) proximal to the patient. The supply section can be rotatable with respect to the longitudinal axis of the inner section, or the inner surface of the inner section may be smooth.

Manicure device with motor-driven rotating file - includes nail cleaner all fitted onto case attached to key ring

The battery operated manicure device comprises a rotating motor-driven filling member which is mounted on a housing which serves as a handle and as the motor casing. A nail cleaning file which can be extended when required for use is also mounted on one side of this housing and the latter can be provided with an eyelet for attaching the device to a key ring. A bulb operated by the battery sued for driving the motor can also the fitted to the housing and a switch is provided so that the bulb or the device can be switched on accordingly. The rotating filling member can also be operated by a clockwork mechanism and motor instead of the battery operated electric motor.

Three-pole adapter set with a plug part and a socket part which may be plugged in the plug part

The invention relates to an adapter set (11). The adapter set is made up of a plug part (13)and a socket part (15). The plug part (13) is provided with at least one three-pole plug contact (20,30,40,50) of a particular country standard at one end and a three pole safety plug socket (17) at the other end of the adapter set (11). The socket part (15) is provided with a three-pole safety plug (19) and a three-pole multi-way plug socket (16). The adapter set (11) comprises one single safety plug (19), namely the plug formed on the socket part (15). It is provided that the polarity of the multi-way plug socket matches the polarity of the plug contacts.

Manicure device with motor-driven rotating file - includes nail cleaner all fitted onto case attached to key ring

The battery operated manicure device comprises a rotating motor-driven filling member which is mounted on a housing which serves as a handle and as the motor casing. A nail cleaning file which can be extended when required for use is also mounted on one side of this housing and the latter can be provided with an eyelet for attaching the device to a key ring. A bulb operated by the battery sued for driving the motor can also the fitted to the housing and a switch is provided so that the bulb or the device can be switched on accordingly. The rotating filling member can also be operated by a clockwork mechanism and motor instead of the battery operated electric motor.

Three-pole adapter set with a plug part and a socket part which may be plugged in the plug part

The invention relates to an adapter set (11). The adapter set is made up of a plug part (13)and a socket part (15). The plug part (13) is provided with at least one three-pole plug contact (20,30,40,50) of a particular country standard at one end and a three pole safety plug socket (17) at the other end of the adapter set (11). The socket part (15) is provided with a three-pole safety plug (19) and a three-pole multi-way plug socket (16). The adapter set (11) comprises one single safety plug (19), namely the plug formed on the socket part (15). It is provided that the polarity of the multi-way plug socket matches the polarity of the plug contacts.

Mutter

控制和优化模拟前端以测量基于纳米材料的气体传感器阵列从而向模式识别算法供应数据的数字后端

一种基于微控制器的数字后端，所述基于微控制器的数字后端用于控制模拟前端以优化基于纳米材料的气体传感器阵列的功率输送、测量和数据收集以向集成模式识别算法供应数据。

Werkzeug

Die Erfindung betrifft ein Werkzeug, mit einem Hauptkörper (1) sowie Eingriffelementen (2) zum direkten Zusammenwirken mit einem Werkstück. Der Hauptkörper (1) ist relativ zu den Eingriffelementen (2) zwischen einer Anbringstellung, die das Positionieren des Werkzeugs am Werkstück ermöglicht, und einer Eingriffstellung, die den Eingriff in das Werkstück ermöglicht, beweglich und es sind Stellmittel (3) und Führungsmittel (4) vorgesehen, über die der Hauptkörper (1) und die Eingriffelemente (2) zusammenwirken, wobei die Führungsmittel (4) eine rampenartige erste Wirkfläche (5) umfassen, über die die Stellmittel (3) in Anbringrichtung (R) verfahren, so dass die Eingriffelemente (2) eine zusätzliche Bewegung in die Eingriffstellung ausführen, und es ist eine zweite, zur Hauptkörperlängsachse im Wesentlichen parallele Wirkfläche (6) vorgesehen, an der der Hauptkörper (1) und die Eingriffselemente (2) in Eingriffsposition aneinander anliegen. Durch die Neuerung kann das eingesetzte Werkzeug in Eingriff gebracht werden, was die bekannten Werkzeuge nicht leisten.

Laser-induced fabrication of metallic interlayers and patterns in polyimide films

Self-metallizing polyimide films are created by doping polyamic acid solutions with metallic ions and solubilizing agents. Upon creating a film, the film is exposed to coherent light for a specific time and then cured. The resulting film has been found to have a metallic surface layer and a metallic subsurface layer (interlayer). The layer separating the metallic layer has a uniform dispersion of small metal particulates within the polymer. The layer below the interlayer has larger metal particulates uniformly distributed within the polymer. By varying the intensity or time of exposure to the coherent light, three-dimensional control of metal formation within the film is provided.

Furnace.

Netzstecker

Adaptateur pour interface de couplage

Sæk, navnlig Ventilsæk, eller lignende af Papir eller lignende og Apparat til dens Fremstilling.

Klemmrollenschaltwerk für Vorwärts- und Rückwärtsgang mit verschiedener Geschwindigkeit sowie für Freilauf und Bremsung.

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Mutter

Die Erfindung betrifft eine Mutter (10), mit: einem Außenkörper (16) mit axialer Durchgangsöffnung (22); einem Innenkörper, der in der Durchgangsöffnung in axialer Richtung verschiebbar aufgenommen ist und in axialer Richtung in wenigstens zwei Backen (18, 20) geteilt ist, die jeweils an ihrer radial inneren Fläche ein Innengewindesegment (24) tragen; ersten Führungsmitteln (26) an dem Außenkörper; und zweiten Führungsmitteln (30) an den Backen, die derart mit den ersten Führungsmitteln zusammenwirken, dass die Backen, wenn der Außenkörper relativ zum Innenkörper in Löserichtung verschoben wird, radial auswärts verschoben werden und, wenn der Außenkörper relativ zum Innenkörper in Anziehrichtung verschoben wird, radial einwärts verschoben werden. Da die Backen beim Verschieben in radialer Richtung bewegt werden, können deren Innengewindesegmente leichtgängig in Eingriff mit dem Außengewinde einer Gewindestange gebracht werden. Da die Backen zudem keine Abschnitte mit gewindefreier Ausnehmung erfordern, muss ihre Länge nur der gewünschten Länge des Innengewindes entsprechen.

Attachment for motion-picture projecting machines

Siebwand für Zerkleinerungsvorrichtungen.

Transportapparat med roterende Vingehjul til Transport af mel- eller kornformet Gods.

Zařízení k rozebírání stohů vypalovacích pouzder pro keramické výrobky

Rohrpostanlage mit drei oder mehr Einzelstationen

Geräuschdämpfer für Türen und Fenster

Verfahren und vorrichtung zum laserbohren

Verfahren zum Laserbohren mit einem außerhalb des Bohrloches befindlichen Laserstrahlgenerator, wobei dem Laserbohrkopf über das Bohrgestänge flüssiger Stickstoff zugeführt wird, welcher im Bereich des Bohrkopfes in den gasförmigen Zustand überführt wird und der aufgeteilt wird in einen das Laser-Leitrohr (19) in Richtung Erdoberfläche durchströmenden Schutzgasstrom (18) und einen Fördergasstrom (15), der das abgelöste Gesteinsmaterial über den Ringraum austrägt. Ein Heizgasstrom (10) wird in der elektrischen Heizeinrichtung (11) beheizt und gegen die vom Laserstrahl beaufschlagte Bohrlochsohle gerichtet.

岩石層にボーリング孔を加工する方法および装置

ボーリング孔の外側に位置するレーザビーム発生器を用いてレーザ掘削するための方法であって、レーザボーリングヘッドにボーリングロッドを介して液状の窒素を供給し、液状の窒素をボーリングヘッドの領域においてガス状の状態に移行させ、レーザガイド管（１９）を地表に向かう方向に通流する保護ガス流（１８）と、環状空間を介して剥離させられた岩石材料を搬出する搬送ガス流（１５）とに分割する方法。加熱ガス流（１０）は、電気的な加熱装置（１１）により加熱され、レーザビームが加えられた坑底に向けられる。

Verfahren und vorrichtung zum laserbohren

控制和优化模拟前端以测量基于纳米材料的气体传感器阵列从而向模式识别算法供应数据的数字后端

一种基于微控制器的数字后端，所述基于微控制器的数字后端用于控制模拟前端以优化基于纳米材料的气体传感器阵列的功率输送、测量和数据收集以向集成模式识别算法供应数据。

Mutter

Die Erfindung betrifft eine Mutter mit einem Spannkörper (1), einer aus Gewindesegmenten (2, 3) zusammengesetzten Gewindeeinheit und mit Führungsstiften (5, 6). Die Gewindesegmente (2, 3) weisen eine gebogene Innenseite auf und werden durch eine Spreizfeder (8) gegen die Kraft eines Spannkörpers auseinandergedrückt. Die Gewindeeinheit weist Führungsmittel auf, die die Gewindesegmente (2,3) in der Segmentaufnahme führen und bei Aufschieben des Spannkörpers (1) die Innenseiten aufeinander zu bewegen. Zum Schutz der Spreizfeder (8) sind die Seitenflächen (11) der Gewindesegmente (2, 3) konturiert, um im hinteren Bereich der Mutter vor der Spreizfeder (11) einen Sicherungsanschlag (7) für die Führungsstifte (5, 6) zu bilden. Zum Schutz der Gewindegänge sind an den Rändern der Gewindesegmente (2, 3) glatte Bolzenauflagen (17) vorgesehen.

Rohrpostanlage mit drei oder mehreren Einzelstationen

In mehrere Abteilungen unterteilter LuftschifftragIn mehrere Abteilungen unterteilter Luftschifftragkörper. körper.