07-11-2013 дата публикации
Номер: US20130295261A1
Принадлежит:
Senomyx, Inc.
The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions, 2. The compound of claim 1 , wherein Y is alkyl claim 1 , substituted alkyl claim 1 , aryl claim 1 , substituted aryl claim 1 , arylalkyl claim 1 , substituted arylalkyl claim 1 , carbocyclyl claim 1 , or substituted carbocyclyl.3. The compound of claim 1 , wherein A is monocyclic five- or six-membered heteroaryl.4. The compound of claim 1 , wherein:A is monocyclic five-membered heteroaryl;Y is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, carbocyclyl, substituted carbocyclyl, heteroarylalkyl, or substituted heteroarylalkyl;{'sub': 2', '2', '2, 'sup': 3', '4', '3', '3', '3', '3', '3', '3', '4', '3', '4', '3', '3', '3', '3', '3', '4', '4', '3', '3', '4', '5', '3', '4', '3', '3', '4', '3', '4', '4', '3', '3, 'X is —O—, —S—, —S(O)—, —S(O)—, —C(RR)—, —C(O)—, —C(S)—, —C(═NR)—, —C(O)O—, —N(R)—, —OC(O)—, —N(R)C(O)—, —C(O)N(R)—, —C(═N—OR)—, —C(═NR)—NR—, —N(R)C(═NR)—, —N(R)C(S)—, —C(S)—N(R)—, —N(R)S(O)—, —S(O)—N(R)—, —N(R)C(—NR)O—, —C(═NR)O—N(R)—, —N(R)—C(═NR)—N(R)—, —N(R)N(R)C(O)O—, —N(R)C(O)O—, —N(R)C(O)N(R)—, —NR—C(O)—C(O)—NR—, —C(O)—C(O)—NR—, —P(O)(OR)—, or —P(O)(R)—;'}Z is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, carbocyclyl, substituted carbocyclyl, heteroarylalkyl ...
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