28-09-2017 дата публикации
Номер: US20170275224A1
Принадлежит:
Unigen, Inc.
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin. 132-: (canceled)34. The compound of claim 33 , wherein R═R═H and Ris selected from 1′-(3′ claim 33 ,5′-dimethoxy)phenyl; 1′-(3′ claim 33 ,5′-dihydroxy)phenyl; 1-(2′ claim 33 ,4′ claim 33 ,6-trimethoxyphenyl); R=Me claim 33 , R═OH claim 33 , and Ris 1′-(2′ claim 33 ,4′-dihydroxy)phenyl; R=Me claim 33 , R═O claim 33 , and Ris 1′-(2′ claim 33 ,4′-dihydroxy)phenyl; and R═R═H claim 33 , R—CHCHOH.35. The compound of selected from the group consisting of 4-(3-(3 claim 33 ,5-dimethoxyphenyl)propyl)benzene-1 claim 33 ,3-diol (28) claim 33 , 4-(3-(3 claim 33 ,5-dimethoxyphenyl)-1-hydroxypropyl)benzene-1 claim 33 ,3-diol (29) claim 33 , 4-(3-(3 claim 33 ,5-dihydroxyphenyl)propyl)benzene-1 claim 33 ,3-diol (30) claim 33 , 4-(3-(2 claim 33 ,4 claim 33 ,6-trimethoxyphenyl)propyl)benzene-1 claim 33 ,3-diol (31) claim 33 , 4-(3-(2 claim 33 ,4-dihydroxyphenyl)propyl)-2-methylbenzene-1 claim 33 ,3-diol (32) claim 33 , 4-(3-(2 claim 33 ,4-dihydroxy-3-methylphenyl)-3-(2 claim 33 ,4-dihydroxyphenyl)propane-1-one (33) claim 33 , 4-(5-hydroxypentyl)benzene-1 claim 33 ,3-diol (34).36. A composition of matter comprising the compound of .37. The composition of matter of claim 36 , wherein the compound is selected from the group consisting of compounds 4-(3-(3 claim 36 ,5-dimethoxyphenyl)propyl)benzene-1 claim 36 ,3-diol (28) claim 36 , 4-(3-(3 claim 36 ,5-dimethoxyphenyl)-1-hydroxypropyl)benzene-1 claim 36 ,3-diol (29) claim 36 , 4-(3-(3 claim 36 ,5-dihydroxyphenyl)propyl)benzene-1 claim 36 ,3-diol (30) claim 36 , 4-(3-(2 claim 36 ,4 claim 36 ,6-trimethoxyphenyl)propyl)benzene-1 claim 36 ,3-diol (31) claim ...
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