11-03-2021 дата публикации
Номер: US20210068429A1
Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, diet supplements) comprising deuterated caffeine. The provided compositions may be useful for treating and/or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder. 1140-. (canceled)142. The nutritional supplement of claim 141 , wherein at least two to eight instances of Y are deuterium.143. The nutritional supplement of claim 141 , wherein nine or ten instances of Y are deuterium.147. The nutritional supplement of claim 141 , wherein the nutraceutically acceptable salt of the compound of Formula (I) is an HCl claim 141 , sulfate claim 141 , acetate claim 141 , phosphate claim 141 , diphosphate claim 141 , maleate claim 141 , citrate claim 141 , mesylate claim 141 , nitrate claim 141 , tartrate claim 141 , or gluconate salt.148. The nutritional supplement of claim 147 , wherein the salt is a citrate salt.151. The nutritional supplement of claim 141 , comprising about 1 mg to about 10 claim 141 ,000 mg of the compound of Formula (I) claim 141 , or a nutraceutically acceptable salt claim 141 , hydrate claim 141 , or solvate thereof.152. The nutritional supplement of claim 141 , comprising about 1 mg to about 1000 mg of the compound of Formula (I) claim 141 , or a nutraceutically acceptable salt claim 141 , hydrate claim 141 , or solvate thereof.153. The nutritional supplement of claim 141 , comprising about 1 mg/ml to about 100 mg/ml of the compound of Formula (I) claim 141 , or a nutraceutically acceptable salt claim 141 , hydrate claim 141 , or solvate thereof.154. The nutritional supplement of claim 141 , comprising about 10 mg/ml to ...
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