КРИОЗОНД

Изобретение относится к медицинской технике к криозонду, который подходит прежде всего для извлечения проб ткани в сильно разветвленных сосудистых системах, таких как, например, сосудистые системы, например, для взятия проб ткани в верхних мочевыводящих путях, в частности в чашечно-лоханочной системе почек. Криозонд для извлечения проб ткани пациента при помощи эндоскопа имеет гибкий шланг, проточный канал и по меньшей мере один гибкий тяговый элемент. Гибкий шланг имеет по меньшей мере один просвет и снабжен на своем дистальном конце головкой. Шланг выполнен с возможностью его выдвижения из эндоскопа, втягивания в эндоскоп и изгибания эндоскопом. Проточный канал сообщается своим дистальным концом с внутренним пространством головки для подачи в головку текучей криогенной среды. По меньшей мере один гибкий тяговый элемент расположен в шланге и простирается по меньшей мере на части длины шланга для передачи тяговых усилий, прикладываемых к головке при перемещении криозонда в проксимальном ...

УСТРОЙСТВО ДЛЯ ГЕРМЕТИЧНОГО СОЕДИНЕНИЯ НАПОРНОГО ШЛАНГА С ЭЛЕМЕНТОМ ДЛЯ ЗАХВАТЫВАНИЯ ИЛИ С СОЕДИНИТЕЛЕМ ХИРУРГИЧЕСКОГО ИНСТРУМЕНТА

Изобретение относится к медицине и может быть использовано для передачи текучей среды. Устройство содержит, по меньшей мере, один герметизирующий элемент, который, в собранном состоянии, расположен между элементом для захватывания и напорным шлангом. Опорный элемент расположен в области соединения во внутреннем пространстве напорного шланга. Герметизирующий элемент зажат или может быть зажат между опорным элементом и напорным шлангом с одной стороны и элементом для захватывания с другой стороны. 2 н. и 8 з.п. ф-лы, 3 ил.

МЕДИЦИНСКИЙ ИНСТРУМЕНТ И ШТЫРЕВОЙ СОЕДИНИТЕЛЬ ДЛЯ ЭТОГО ИНСТРУМЕНТА

Изобретение относится к медицинской технике. Хирургический инструмент содержит головку для использования на пациенте, подающую линию, штыревой соединитель инструмента, штыревые соединители текучей среды и дренажное отверстие. Подающая линия содержит линии для газообразной, жидкой или сверхкритической текучей среды и оболочку. Сквозь внутреннее пространство оболочки проходят линии для текучей среды, одна из которых транспортирует текучую среду к головке, а другая отводит текучую среду из головки. Штыревой соединитель инструмента имеет грань и полностью заполненное литейным компаундом внутреннее пространство. Штыревые соединители текучей среды соединены по текучей среде с линиями для текучей среды и расположены на грани. Дренажное отверстие для сброса давления соединено посредством дренажного шланга или трубы с внутренним пространством оболочки для выпуска любой возникающей протечки текучей среды, посредством чего внутреннее пространство соединено с атмосферой. Дренажное отверстие расположено ...

КРИОХИРУРГИЧЕСКИЙ ИНСТРУМЕНТ

Изобретение относится к криохирургическому инструменту, который работает с использованием эффекта Джоуля-Томсона. Криохирургический инструмент имеет головку с расположенной в ней расширительной камерой, линию подачи для подачи текучей среды, прежде всего газа, в расширительную камеру, присоединенную к расширительной камере возвратную линию для отвода газа из расширительной камеры. Линия подачи имеет участок капиллярной линии, оканчивающийся в расширительной камере с возможностью охлаждения головки выходящей из него в расширительную камеру текучей средой за счет эффекта Джоуля-Томсона. Линия подачи имеет, по меньшей мере, первый участок и второй участок с различными по величине внутренними поперечными сечениями, проточный канал в линии подачи воронкообразным образом сужается на переходном участке от первого участка ко второму участку в направлении потока текучей среды к расширительной камере. Использование изобретения позволяет обеспечить возможность выполнения головки инструмента с удлиненной ...

КРИОХИРУРГИЧЕСКИЙ ЭНДОКАРДИАЛЬНЫЙ АППЛИКАТОР

Полезная модель относится к медицине, а именно к кардиохирургии, и может применяться для криоабляции миокарда предсердий, легочных вен при открытых операциях на митральном клапане в лечении сопутствующей фибрилляции предсердий. Криохирургический эндокардиальный аппликатор содержит сердечник 1, выполненный из пористого титана, прикрепленный к гибкому держателю 2, изготовленному из пластичного титана. Гибкий держатель может быть изогнут в любой плоскости, что позволяет получить доступ действующего элемента (сердечника) к неудобным участкам предсердий, не задевая окружающие участки. Технический результат применения предлагаемого криоаппликатора состоит в увеличении продолжительности цикла заморозки за счет высокой поглощаемости рабочего вещества, более длительного поддержания криоаппликатора в неизменном режиме ультранизкой температуры и предотвращения «протекания» жидкого азота при обеспечении адаптации устройства для выполнения криодеструкции участков миокарда. 1ил.

СПОСОБ ЛОКАЛЬНОЙ ДЕСТРУКЦИИ ПЕРВИЧНЫХ И МЕТАСТАТИЧЕСКИХ НОВООБРАЗОВАНИЙ ОРГАНОВ БРЮШНОЙ ПОЛОСТИ И ЗАБРЮШИННОГО ПРОСТРАНСТВА С ЛАПАРОСКОПИЧЕСКИМ ДОСТУПОМ

Изобретение относится к медицине, абдоминальной хирургии. Выполняют комбинированное крио- и РЧА-воздействие. Для чего в новообразование через троакар вводят криозонд, осуществляют замораживание новообразования до достижения температуры около -184 °С. Затем после пассивного оттаивания криозонд извлекают. Через тот же троакар в новообразование по ходу ранее стоявшего криозонда вводят активный РЧА-электрод, осуществляют абляцию сначала новообразования, затем пункционного канала. Способ позволяет снизить риск рецидива заболевания и тем самым повысить эффективность лечения. 2 з.п. ф-лы., 14 ил., 1 пр.

ТЕРМОЛЕЗВИЕ КРИОТЕПЛОВОГО КОАГУЛОТОМА

Полезная модель относится к медицинской технике, в частности к хирургическим инструментам, и может быть использована для разъединения различных типов тканей, удаления патологически измененных участков тканей и органов.Целью разработки технического устройства, предлагаемого в качестве полезной модели, является повышение эксплуатационной надежности термолезвия, расширение доступности его использования в различных ситуационных обстоятельствах, а также увеличение эффективности и производительности выполняемых с его помощью хирургических вмешательств.Сущность полезной модели: термолезвие выполнено из тонкостенной листовой жаропрочной стали в виде помещаемого в электроизолирующий защитный кожух сменного полого наконечника клинообразной формы, боковые стенки которого частично разъединены тонкими прорезями в местах предполагаемого расположения в области нижнего краевого изгиба точечных электрических нагревателей с сохранением при этом по всему периметру целостности верхней кромки боковых стенок ...

НАСАДКА ДЛЯ КРИОИНСТРУМЕНТА

Полезная модель относится к медицинской техники, а именно к устройствам для криовоздействия на биоткани, и может быть применена в хирургии и терапии при работе на многофункциональном аппарате КРИО-01 «ЕЛАМЕД», работающем в режиме «Обдув».Технический результат заключается в снижении травмирования живой и здоровой ткани вокруг раны и возможности контролировать процедуру.Насадка для криоинструмента, состоящая из цилиндрического корпуса, имеющего с одной стороны полость, а другая сторона заканчивается форсункой, и съемного наконечника, установленного на корпусе насадки со стороны форсунки. Наконечник выполнен в виде цельной детали, состоящей из трех последовательных участков: цилиндрического, имеющего внутренний диаметр, равный диаметру корпуса насадки, конического - в виде усеченного конуса и третьего - в виде полой трубки с открытым концом.

СПОСОБ ЧРЕСКОЖНОЙ ПУНКЦИОННОЙ КРИОАБЛАЦИИ ПРИ ОПУХОЛЯХ КОСТЕЙ

Изобретение относится к медицине, а именно к криохирургии и онкологии, и может быть использовано для чрескожной пункционной криоаблации при опухолях костей. В мягкие ткани, находящиеся в непосредственной близости от опухоли кости, вводят один или более криозондов по запланированной траектории, прилегающей к зоне опухоли на всем ее протяжении. Выполняют криодеструкцию опухоли путем двух циклов охлаждения опухоли с длительностью экспозиции не менее 8 минут с пассивным оттаиванием зоны воздействия между циклами и после окончания процедуры. Начало длительности экспозиции определяют от момента формирования ледяной сферы, распространяющейся за пределы наиболее удаленного от криозонда полюса опухоли не менее чем на 5 мм. После выполнения второго цикла криодеструкции криозонды извлекают. В случае неудовлетворительной визуализации ледяной сферы внутри кости, ее границы достраивают с учетом видимой части сферы в мягких тканях. Способ обеспечивает снижение риска повреждения органов и анатомических ...

Способ криодеструкции кожных новообразований

Изобретение относится к медицине, а именно к дерматологии, и может быть использовано в криохирургии при проведении криогенной деструкции мягкотканных доброкачественных экзофитных новообразований кожи. Проводят захват доброкачественного экзофитного новообразования двумя криоаппликаторами, диаметром 3 мм с ватным наконечником, при этом наконечники криопалочек располагают под углом 45° к поверхности кожи. Сжимают ножку новообразования до фиксации ткани между криопалочками, после чего криопалочки сводят между собой так, чтобы они стали параллельны друг другу, и оттягивают палочками новообразование от здоровых тканей, сохраняя давление наконечников на ножку новообразования, при этом визуально контролируют параллельность криопалочек, экспозиция криодеструкции составляет 10-20 с. Способ позволяет уменьшить травматизацию прилежащих здоровых тканей, удалять новообразования небольших размеров, минимизировать риски возникновения рубцовых осложнений, за счет совокупности приемов заявленного изобретения ...

СПОСОБ КОМПЬЮТЕРНО-ТОМОГРАФИЧЕСКОГО МОНИТОРИНГА ЛЕДЯНОЙ СФЕРЫ ПРИ ВЫПОЛНЕНИИ ЧРЕСКОЖНОЙ ПУНКЦИОННОЙ КРИОАБЛАЦИИ ОПУХОЛЕЙ КОСТЕЙ

Изобретение относится к медицине, а именно к криохирургии и онкологии, и может быть использовано для компьютерно-томографического мониторинга ледяной сферы при выполнении чрескожной пункционной криоаблации опухолей костей. Перед процедурой криоаблации пациента располагают на столе компьютерного томографа (КТ) и вводят в наркоз. Выполняют предоперационное КТ сканирование и получают реформированные изображения зоны интереса. Устанавливают в опухоль по меньшей мере один криозонд. В процессе цикла охлаждения отклоняют гентри компьютерного томографа таким образом, чтобы ось установленных криозондов не совпадала с плоскостью сканирования. Производят контрольное сканирование без перемещения стола томографа и получают контрольные изображения. Контрольные изображения сопоставляют с реформированными изображениями, при этом угол реформации равен углу наклона гентри томографа. Способ обеспечивает устранение артефактов от криозондов, улучшает качество КТ-изображений за счет наклона гентри. 10 ил., 1 ...

УСТРОЙСТВО ДЛЯ ПОДАЧИ ХЛАДАГЕНТА КРИОХИРУРГИЧЕСКОГО АППАРАТА В АППЛИКАТОР

Устройство относится к медицинской технике и предназначено для использования при проведении хирургических операций с применением глубокого замораживания патологических тканей с помощью жидкого азота. Устройство для подачи хладагента криохирургического аппарата в аппликатор содержит систему подачи хладагента, выполненную в виде паропровода и коаксиально расположенных подвижной и неподвижной трубок. Неподвижная трубка закреплена в паропроводе, подвижная трубка входит в неподвижную с минимальным зазором, выполнена с возможностью перемещения внутри неподвижной трубки по всей длине, выдвижения для подключения аппликатора с упором в его дно и вдвижения в неподвижную трубку с обеспечением подачи хладагента на всю длину аппликатора. Паропровод выполнен с возможностью обеспечения герметичного соединения с аппликатором, а подвижная трубка выполнена с прорезями в концевой части и отверстиями в боковой поверхности. Изобретение позволяет расширить функциональные возможности устройства. 1 з.п. ф-лы, ...

АКТИВНАЯ ДОСТАВКА ЛЕКАРСТВЕННОГО СРЕДСТВА В ЖЕЛУДОЧНО-КИШЕЧНОМ ТРАКТЕ

... 1. Устройство для введения лекарственного средства, включающее принимаемую внутрь капсулу, которая содержит:лекарственное средство, содержащееся в капсуле;чувствительный к окружающей среде механизм, выполненный таким образом, чтобы изменять свое состояние в ответ на положение капсулы в желудочно-кишечном (ЖК) тракте пациента;первый и второй электроды; иуправляющий элемент, выполненный таким образом, чтобы в ответ на изменение состояния чувствительного к окружающей среде механизма облегчать прохождение лекарственного средства через эпителиальный слой ЖК тракта, путем обеспечения подачи первым и вторым электродами серии импульсов с силой тока менее чем приблизительно 10 мА, частотой от 10 до 100 Гц и длительностью импульса от приблизительно 0,5 мс до приблизительно 3 мс.2. Устройство по п.1, отличающееся тем, что ток включает ток силой менее чем приблизительно 7 мА, и тем, что управляющий элемент выполнен таким образом, чтобы обеспечивать подачу первым и вторым электродами серии импульсов ...

Способ хирургического лечения опухолей головного мозга

Изобретение относится к медицине, а именно к нейрохирургии. Проводят МРТ и ПЭТ обследование и стереотаксическую деструкцию опухоли. После стереотаксической криодеструкции, при опухоли мозга в объеме, превышающем 20 см, удаляют около 30% ее объема, подвергнутого криохирургическому воздействию. Удаление осуществляют методом стереотаксической аспирации с помощью эвакуатора шнекового типа. Способ позволяет снизить послеоперационные осложнения, что достигается за счет создания внутренней декомпрессии. 2 ил., 1 пр.

Способ замедления старения женщин

Изобретение относится к медицине и касается способа замедления старения женщин путем забора ткани яичников до наступления менопаузы и реимплантации ткани в организм при наступлении менопаузы, где забирают часть кортикального и медуллярного слоев яичника, консервируют, не ранее чем через 3 года размораживают, готовят крупнодисперсную суспензию и раз в 2-4 месяца в перименопаузе вводят ее подкожно вместе с менопаузальной гормональной терапией. Изобретение обеспечивает отсутствие осложнений, связанных с развитием реакции отторжения трансплантатов, а также необходимости иммуносупрессивной терапии после возврата тканей. 1 пр.

Способ профилактики инфекционных осложнений на основе воздушной плазмы и экзогенного оксида азота при сердечно-сосудистых вмешательствах

Изобретение относится к медицине, а именно к области сердечно-сосудистой хирургии. Для обработки раны применяют температурный эффект воздушной холодной плазмы и воздействие экзогенным оксидом азота. При этом по завершении основного этапа операции воздействуют воздушно-плазменными потоками аппарата «Плазон» на ткань ранее рассеченной грудины в режиме коагулятора с экспозицией по 1 минуте на каждый из краев операционной раны. После ушивания и сведения краев грудины воздействуют воздушно-плазменными потоками на мягкотканую рану по всей ее поверхности в режиме стимулятора с экспозицией по 2 минуты на каждый из краев. Послеоперационное воздействие осуществляют на швы раны воздушно-плазменными потоками в режиме стимулятора с экспозицией 1 минута по линии швов с обеих сторон, с общей экспозицией 2 минуты, один раз в день, в течение 3 суток. Затем до снятия швов обработку линии шва осуществляют в режиме стимулятора с экспозицией 3 минуты. Способ позволяет снизить количество инфекционных и раневых ...

УСТРОЙСТВО ДЛЯ ИНДУКЦИИ УПРАВЛЯЕМОЙ ГИПОТЕРМИИ ГОЛОВНОГО МОЗГА

Группа изобретений относится к медицине. Устройство для индукции управляемой гипотермии головного мозга субъекта содержит два криоаппликатора, средство охлаждения хладоносителя, гидравлическую систему, средства регистрации температуры по меньшей мере одного участка тела субъекта и средство управления. Один криоаппликатор выполнен в форме криоаппликатора-шлема, внутренняя поверхность которого контактирует с поверхностью кожи волосистой области головы субъекта. Другой криоаппликатор выполнен в виде криоаппликатора-воротника, внутренняя поверхность которого контактирует с шеей субъекта в области проекции внутренних сонных артерий. Оба криоаппликатора выполнены с возможностью циркуляции в них жидкого хладоносителя. Гидравлическая система установлена с возможностью осуществления циркуляции жидкого хладоносителя в по меньшей мере одном указанном криоаппликаторе. Средства регистрации температуры включают по меньшей мере одну антенну для неинвазивной регистрации собственного ЭМИ глубоких тканей ...

Устройство для общей воздушной криотерапии

Изобретение относится к медицинской технике и может быть использовано для проведения криотерапевтических процедур посредством кратковременного экстремального охлаждения всей поверхности тела человека потоками сухого воздуха с температурой до -180°С. Устройство для общей воздушной криотерапии содержит, по меньшей мере, одну процедурную камеру и соединенное с ней средство, предназначенное для получения охлаждающей газообразной среды, включающее блок воздушного охлаждения и соединенные последовательно компрессорный блок, блок фильтров, рефрижераторный осушитель, абсорбционный осушитель и блок детандера. Компрессорный блок включает соединенные последовательно средство забора атмосферного воздуха, компрессор первой ступени, промежуточный холодильник, компрессор второй ступени, расположенный на одном валу с компрессором первой ступени, и концевой холодильник. Блок фильтров включает соединенные последовательно влагоотделитель и по меньшей мере два фильтра. Блок детандера включает соединенные последовательно ...

СПОСОБ ОДНОВРЕМЕННОЙ ХИРУРГИЧЕСКОЙ КОРРЕКЦИИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ И ПАТОЛОГИИ АТРИОВЕНТРИКУЛЯРНЫХ КЛАПАНОВ

Изобретение относится к медицине, а именно к сердечно-сосудистой хирургии. Выполняют аблацию в правом и левом предсердиях, изолируя ушко левого предсердия, и аннулопластику трикуспидального и митрального клапанов. Вскрывают правое предсердие продольным разрезом вдоль атриовентрикулярной борозды. При помощи криоаблации изолируют зону «типичного» трепетания предсердия, при этом криоизолирующую линию располагают между двумя краями разреза правого предсердия и проводят ее кпереди от основания нижней полой вены и сзади от коронарного синуса. Затем изолируют зону «атипичного» трепетания предсердия, для чего криоизоляционную линию проводят сначала между двумя разрезами правого предсердия в проксимальном сегменте этого предсердия, затем вдоль основания ушка правого предсердия, основания верхней полой вены и заканчивают над верхним краем верхней правой легочной вены. Осуществляют доступ к левым отделам сердца (левое предсердие) и выполняют криоаблацию: наносят линию вдоль задней створки митрального ...

Способ лечения инфекционных осложнений после сердечно-сосудистых вмешательств

Изобретение относится к медицине, а именно к сердечно-сосудистой и торакальной хирургии, и может быть использовано при лечении инфекционных осложнений, возникающих после сердечно-сосудистых вмешательств. Для этого проводят ежедневную обработку всей раневой поверхности воздушно-плазменными потоками в режиме стерилизации в течение 3-5 дней с экспозицией 2-3 минуты по каждому краю операционной раны, до снижения уровня бактериальной обсемененности до 10-5 и ниже. Затем в течение 2-3 дней обрабатывают послеоперационную рану воздушно-плазменными потоками в режиме биологической стимуляции с последующим закрытием раны со сквозным дренированием. Далее проводят обработку раны через сквозное дренирование в режиме биологической стимуляции экзогенным оксидом азота с экспозицией 1-2 мин ежедневно в течение 10 дней с объемом экзогенного оксида азота 2 л/мин. Дополнительно ежедневно воздействуют в режиме стерилизации по линии швов в течение 3 минут. Швы снимают на 14-е сутки с одновременным удалением дренажа ...

Способ лечения больных раком кожи лица

Изобретение относится к медицине, а именно к онкологии, и может быть использовано для лечения больных раком кожи лица. Проводят лучевую терапию с предварительным локальным охлаждением опухоли до достижения температуры замораживания на клинически определяемой границе опухоли и здоровой ткани. При этом на первом этапе лечения проводят дистанционное облучение электронами или фотонами разовой очаговой дозой 2 Гр ежедневно в течение пяти дней в неделю с двухдневным перерывом до достижения суммарной очаговой дозы 46 Гр. После завершения первого этапа продолжают лечение методом контактной лучевой терапии на область остаточной опухоли или ложа опухоли с помощью аппликатора, соответствующего по размерам опухоли, разовой очаговой дозой 3 Гр, три фракции до суммарной очаговой дозы 9 Гр. Суммарная очаговая доза за два этапа лечения составляет 60 Гр по изоэффекту. Способ обеспечивает повышение эффективности лечения, снижение лучевой нагрузки на соседние прилежащие к опухоли нормальные ткани при максимальном ...

Аппарат для криолиполиза

Изобретение относится к устройствам, позволяющим производить лечебное воздействие на пациента посредством вакуума и заданной температуры, и может применяться в различных областях медицины, в частности в косметологии. Аппарат для криолиполиза состоит из рабочей насадки аппарата, источника очищенного сжатого воздуха, двух двухходовых электромагнитных клапанов, датчика температуры, вакуумметра, платы управления с LCD-монитором и интерфейсом, двух вихревых трубок Ранка-Хилша, подключаемых к источнику очищенного сжатого воздуха посредством стандартного байонетного соединения. Первая вихревая трубка Ранка-Хилша, генерирующая холодный поток, соединена одним концом посредством теплоизолированного шланга с быстросъемными соединениями с рабочей насадкой аппарата через датчик температуры и другим концом соединена с источником очищенного сжатого воздуха посредством стандартного байонетного соединения через двухходовой электромагнитный клапан. Вторая вихревая трубка, генерирующая вакуум, соединена одним ...

АППАРАТ ДЛЯ ЛЕЧЕНИЯ ХОЛОДОМ

УСТРОЙСТВО ДЛЯ ГЕРМЕТИЧНОГО СОЕДИНЕНИЯ НАПОРНОГО ШЛАНГА С ЭЛЕМЕНТОМ ДЛЯ ЗАХВАТЫВАНИЯ ИЛИ С СОЕДИНИТЕЛЕМ ХИРУРГИЧЕСКОГО ИНСТРУМЕНТА

... 1. Устройство для герметичного соединения напорного шланга (2) с элементом (4) для захватывания или с соединителем хирургического инструмента (30), содержащее,по меньшей мере, один герметизирующий элемент (8), который в собранном состоянии расположен между элементом (4) для захватывания и напорным шлангом (2) в области (10) соединения таким образом, чтобы создавать герметичность,отличающееся тем, что содержитопорный элемент (12), причем указанный опорный элемент расположен в области (10) соединения во внутреннем пространстве (14) напорного шланга (2) таким образом, что герметизирующий элемент (8) зажат или может быть зажат между опорным элементом (12) и напорным шлангом (2) с одной стороны и элементом (4) для захватывания с другой стороны.2. Устройство по п.1, отличающееся тем, чтогерметизирующий элемент (8) содержит, по меньшей мере, одно уплотнительное кольцо (18) или подобный охватывающий элемент, в собранном состоянии опоясывающий напорный шланг (2) и опорный элемент (12).3. Устройство ...

КАТЕТЕРНЫЕ УСТРОЙСТВА, СИСТЕМЫ И СПОСОБЫ ДЛЯ ПОЧЕЧНОЙ НЕЙРОМОДУЛЯЦИИ

... 1. Катетер для термической модуляции нервов почки из просвета почечной артерии пациента, содержащий следующие элементы:удлиненный вдоль оси трубчатый стержень, содержащий проксимальный и дистальный концы;рукоятку, расположенную в проксимальном направлении от проксимального конца удлиненного трубчатого стержня;гибкую трубчатую структуру, расположенную в дистальном направлении от дистального конца удлиненного трубчатого стержня, сконструированную с возможностью образовывать нестационарный изгиб в месте ответвления почечной артерии от аорты пациента;отклоняющийся трубчатый корпус, расположенный в дистальном направлении от гибкой трубчатой конструкции;элемент регулировки изгиба, функционально связанный с отклоняющимся трубчатым корпусом;контроллер изгиба, расположенный в рукоятке и функционально связанный с элементом регулировки изгиба; при этом контроллер изгиба сконструирован с возможностью приложения усилия через элемент регулировки изгиба к отклоняющемуся трубчатому корпусу;секция амортизации ...

УСТРОЙСТВО ДЛЯ ОБРАБОТКИ ПУНКЦИОННО-ДРЕНАЖНОГО КАНАЛА У БОЛЬНЫХ С ПАРАЗИТАРНЫМ ПОРАЖЕНИЕМ ПЕЧЕНИ ПОСЛЕ ДРЕНИРОВАНИЯ ПОЛОСТИ РАСПАДА

Полезная модель относится к хирургическим медицинским инструментам, которые могут быть использованы для обработки криовоздействием пункционно-дренажного канала у больных с паразитарным (альвеококковым)поражением печени после санационного дренирования полости распада как окончательного вида вмешательства, либо как предварительного перед удалением патологического очага. Устройство для криообработки пункционно-дренажного канала у больных с паразитарным поражением печени после дренирования полости распадасодержит кольцеобразный элемент, снабженный ручкой. Кольцеобразный элемент выполнен в виде плоской детали с возможностью свободного размещения в отверстии детали рабочей части криоаппликатора без касания поверхности кольцеобразного элемента, а ручка выполнена в виде протяженной детали с рукояткой на конце, при этом угол расположения ручки относительно плоскости кольца составляет от 120 до 140°. Полезная модель направлена на повышение точности при позиционировании криоаппликатора в процессе ...

KATHETER

KRYOCHIRURGISCHE FLÜSSIGKEITSZUFÜHRUNG

Kaelteerzeugende Sonde fuer aerztliche Zwecke

Fuer medizinische oder kosmetische Zwecke bestimmtes Geraet zum Abkuehlen von Oberflaechen beschraenkter Groesse

BALLONKATHETER FÜR KRYOCHIRURGIE

DEHNBARE KRYOCHIRURGISCHE SONDENHÜLLE

MEDIZINISCHES GERAET

Medical examination and treatment device for visualization and treatment of ablation lesion in tissue or vascular surface of heart, has pattern recognizing unit identifying ablation lesion, and display displaying conditioned endoscope image

The device has a flexible catheter (2) arranged at a distal end (6), and an endoscope (12) inserted into a catheter hollow space (10) with an objective (20) positioned in a monitoring position within a balloon (28). A digital image processing system real-time processes an image produced by the endoscope, and includes a pattern recognizing unit that identifies an ablation lesion based on color difference compared to surrounding tissue and local distribution of image entropy marked at the image. A display displays a conditioned endoscope image.

KRYOSONDE

DURCHFLUSSSTEUERUNGSSYSTEM FÜR EINE MEDIZINISCHE VORRICHTUNG

CRYOPROBES

... 1473856 Cryoprobe DRAGERWERK AG 26 April 1974 [26 April 1973] 35843/76 Divided out of 1473855 Heading F4H [Also in Division A5] A cryoprobe comprises a casing 30, a tubular conduit part 16, an air-filled heat-insulating chamber which provides inadequate thermal insulation of a shank section of the casing from the tubular conduit part and heating means 19 to heat the casing 30 thereby compensating for the inadequate thermal insulation (thus enabling the cryoprobe shank to be held in the hand for example). Heating means 13 and thermocouples 14, 20 are also provided. The cryoprobe may comprise a coupling part (22) (Fig. 2, not shown) to which a casing (30) (Fig. 3, not shown) may be releasably coupled by means of plug-and-socket connections (26) and (25) which also connect electrical transmission lines for supplying heating elements (19), (13) and thermocouples (14), (20) which are incorporated in a system for controlling the heating elements. The element (19) may be located in either the ...

Device for use in cryogenic therapeutic treatments

The present invention relates to cryogenic therapeutic treatments and, in particular provides a mechanism and device to facilitate in the application of cryogenic fluids for use in therapeutic treatments. The invention provides an apparatus for the treatment of epidermal lesions by cryogenic substances or fluids, the apparatus comprising a generally planar plastics element 12 having a number of frusto-conical elements 14,16,18, the edges of each frusto-conical element defining lips which are operable to be placed against an epidermis whereby cryogenic fluids may be contained within the frusto-conical element. The apparatus has a handle arrangement 15 with a pair of opposing arms 52, 54 that engage edges of the planar plastic element 12. A shroud or shield element 58 may be incorporated into the handle arrangement.

Skin cooling system

Selective disruption of lipid rich cells utilising a cooling element

A cooling method for selective disruption of lipid rich cells in a non-infant human treatment subject and systems 100 for providing feedback information in connection with the selective disruption of said lipid rich cells, comprising: at least one non-invasive cooling element 110 proximate to an application site of the treatment subject, where the cooling element is effective to decrease the temperature beneath the application site, and where the temperature decrease is sufficient to disrupt and thereby reduce lipid rich cells beneath the application site. At least one feedback device 120 is provided in communication with the at least one cooling element, where the feedback device either provides feedback information sufficient to confirm that non lipid rich cells proximate to the cooling element are not disrupted or provides feedback information sufficient to confirm that the temperature decrease is sufficient to disrupt and thereby reduce lipid rich cells beneath the application site.

Improvements in or relating to a process and device for the freezing of a product to be lyophilized and other products

... 968,018. Freezing liquids. SOC. D'UTILISATION SCIENTIFIQUE ET INDUSTRIELLE DU FROID USIFROID. July 24, 1963 [Oct. 23, 1962], No. 29396/63. Heading F4H. A bottle 1 containing a liquid to be frozen, e.g. blood plasma, is supported in and driven by a rotatable cylindrical sleeve 2 which is partially immersed in a refrigerant bath L. The bottom of the sleeve has a central aperture 10 and disposed around this aperture are impeller blades 9 which, when the sleeve is rotated, force refrigerant upwardly through the annular gap 3 between the bottle and sleeve. The bottle stands on a transverse rod 8 and is centred by a polygonal spring (not shown) disposed in the space 3. A spindle 4 drives the sleeve 2 via a universal joint 5 and supporting strips 6, a flange 12 being provided on the lower part of the sleeve to damp any oscillations which may occur.

CRYO-SURGICAL PROBE

... 1475912 Cryogenic probes DRAGERWERK AG 24 May 1974 [24 May 1973] 33677/76 Divided out of 1475911 Heading A5R The subject matter of this Specification is identical with that described in Specification 1475911 but the claims are directed to a cryogenic probe comprising an optical viewing system and a washing duct. Reference has been directed by the comptroller to Specification. 1402140.

Improvements in or relating to cauterisation probes

A cauterization probe has a heating winding (5) in a hollow section of a cooling portion (4) of the probe, the probe being surrounded, at least in the zone of the heating winding (5), by a plastics material (7) which is stable at temperatures of up to about 200 DEG C and which prevents tissue adhering during the cauterization process. The cooling portion (4) is connected to cooling water lines (1, 2) which feed water to cool the tissue after cauterization. ...

CRYOSURGICAL PROBES

... 1534472 Surgical coding and cauterisation devices ERBE ELEKTROMEDIZIN KG 2 May 1977 [14 May 1976] 18322/77 Heading A5R A cryosurgical probe comprises a heating coil 5 for thawing the probe and cauterisation purposes, fitted into a hollow inner cooling section of the cooling tip, the heating coil being such that cauterisation may follow a freezing procedure, and a film 7 of flexible elastomeric plastics material provided on the outer surface of the probe, at least over the part of the probe causing cauterisation, the plastics material being such as to withstand temperatures of up to 200‹C and to prevent tissue adhering during the cauterisation process. The probe also includes a refrigerant, e.g. liquid nitrogen, supply line 1 inside a heat-insulating shaft 6 and has a temperature sensor 9. The heating coil may have a power rating of 120 Watts to reach cauterisation temperatures. A heat insulating tip 10 is provided to prevent unintended freezing or cauterisation of the bladder wall in a ...

Hypothermia apparatus

... 1,019,028. Cooling apparatus. E. T. ARMSTRONG. Nov. 21, 1963 [Oct. 2,1963], No. 45974/63. Heading A5R. A hypothermia apparatus comprises a closed endless circulating system in which the circulating cooling liquid is a mixture of water and propylene glycol, the system comprising a flexible inflatable bag 92 and a concentric walled tube 90 having an inner passage for supplying the cooling liquid to the bag 92 and an outer passage for removing the cooling liquid from the bag 92. The pressure drop per unit length in each passage is substantially equal. As shown, the apparatus comprises a chest 10 containing a heat exchanger 34 in cooling bath 20, pump 32 and motor 30, (Fig. 4 not shown), concentric walled tube 90 and balloon or bag 92. The cooling bath may comprise water and ice or water and solid carbon dioxide with or without propylene glycol. The apparatus may include means for indicating if the temperature of the cooling liquid rises or drops too much.

CRYO-PROBE

... 1475911 Cryogenic probes DRAGERWERK AG 24 May 1974 [24 May 1973] 23478/74 Heading A5R A cryogenic probe comprises a shank 2 supporting an endoscope 8 displaceable along the shank and a coolable tip 5, the distal portion 4 of the shank being bent over relatively to the remainder. As shown in Fig. 1, the shank is mounted on a handle 3 and the tip 5 constitutes an evaporation chamber for a low-boiling point liquid which is conveyed to and from the tip by co-axial tubes 14, 15 surrounded by an evacuated sheath 17. The shank also contains a guide-tube 7 for insertion of the endoscope 8 and accommodates leads 18 leading to a thermocouple in the probe-tip and to a heating device for the tip. A supply duct 9 and a drainage duct 10, each having openings 11, are provided for circulating washing fluid around the tip, the ducts having a cross sectional shape of approximately a segment of a circle thereby giving an approximately circular overall cross-section to the shank and ducts together. Reference ...

CRYOTHERAPY DEVICE AND METHOD FOR THE TREATMENT OFCERVICAL PRECANCEROUS LESIONS

CRYOTHERAPY DEVICE AND METHOD FOR THE TREATMENT OFCERVICAL PRECANCEROUS LESIONS

CRYOTHERAPY DEVICE AND METHOD FOR THE TREATMENT OFCERVICAL PRECANCEROUS LESIONS

Apparatus of generation of cold, mainly for the application of the cold by contact on the body of living beings.

THERAPEUTIC DEVICE WITH ISOLATION IN THE AREA OF APPLICATION

POINT WITH VARIABLE FORM FOR CRYOABLATIONSGERÄT

KRYOGENI DEVICE

FLOW CONTROL SYSTEM FOR A MEDICAL DEVICE

PROCEDURE AND SYSTEM FOR THE KRYOABLATION OF FIBROADENOMEN

ECHO NEEDLE FOR TRANSVAGINALEN THE ULTRASONIC-ARRANGED REDUCTION OF UTERINER FIBROSE

SURGICAL CLAMP WITH TREATMENT ELEMENTS

KRYOCHIRURGI EQUIPMENT

FLOW CONTROL SYSTEM FOR A MEDICAL DEVICE

DEVICES FOR THE TREATMENT OF FORECOURT FLARES BY MASS ABLATION

LED POINT ION NEEDLE

QATAR ACT SURGERY INSTRUMENTS AND METHODS FOR USE THE SAME

THERAPEUTIC DEVICE

EXTENT-MODERATE ABLATION DEVICE ARRANGEMENT WITH BINARY EXPAND-CASH ELEMENTS

ZAHNPRÜFGERÄT

KRYOCHIRURGI INSTRUMENT WITH DEPARTURE OPENINGS AS WELL AS PROCEDURES

DEVICE TO KRYOBEHANDLUNG

FLEXIBLE KRYOCHIRURGI PROBE COVERING

PRECOOLED MEDICAL VERY LOW-TEMPERATURE DEVICE

EQUIPMENT TO THE BIOPSIE AND TREATMENT OF BREAST TUMORS

PRECOOLED TIEFTEMERATURABTRAGUNGSVERFAHREN

PERCUTANEOUS CATHETER AND GUIDANCE WIRE FOR FILTERING DURING THAT MYOKARDIALEN OR VASKULAREN FABRIC ABLATION

ON AN PELTIER ELEMENT BASING KRYOSONDE

KRYOSONDE

KRYOSTAT

KRYOGENI CATHETER SYSTEM

INTEGRATED KRYO SURGICAL STEERING WHEEL AND MONITOR

DEVICE FOR ELECTRICALPHYSIOLOGICAL TREATMENTS OF THE HEART

Device for ablation of tissue surfaces and related systems and methods

Provided herein are ablation systems having an ablation component with an ablation chamber and an insulation chamber, wherein the ablation chamber comprises a plurality of channels defined there. Other embodiments include ablation systems having a substrate source, a cooling component, and an ablation component. Certain systems are closed-loop systems that reuse the cooling substrate.

Methods for modulation of CAR-T cells

Provided herein are methods of modulating, in vivo, cells engineered with a recombinant receptor, such as a T cell receptor (TCR) or chimeric antigen receptor (CAR). In some embodiments, the methods include disrupting an area in the subject in which the cells are present or likely to be present or were present or were likely to be present, such as a lesion, including a tumor. In some embodiments, the disruption alters the environment of the lesion, e.g. tumor microenvironment. In some embodiments, the disruption is a biopsy. In some aspects, the provided methods result in increased expansion, and, in some cases, a more robust and durable response, of the engineered cells after carrying out the disruption.

Cryoablation system with magnetic resonance imaging detection

A magnetic resonance imaging (MRI) guided surgical system is provided that includes one or more surgical tools having components configured to develop reactive effects when exposed to MR signals generated by the MRI system. The system includes a control system that can determine whether the MR system is generating MR signals, and if the control system determines that the MR system is generating MR signals, mitigates the reactive effects of MR signals on components of the surgical tools. The system can include a cryoablation system with a cryoprobe having a probe shaft being made of a metallic material. If the control system determines that the MR system is generating MR signals, the control system can electrically disconnect the cryoprobe and/or ignore electrical signals generated by the electric heater in response to exposure to MR signals, and/or initiate a cooling operation of the probe shaft, whereby the cooling operation.

Articulated robotic probes

An articulated probe assembly comprises a base, an outer support rod extending through the base, an articulating control portion at a proximal end of the outer support rod, and a steerable portion comprising a plurality of outer links coupled to a distal end of the outer support rod. The steerable portion is manipulated in response to the articulating control portion ...

Apparatus, systems, and methods for planning and performing guided and free-handed transperineal prostate biopsies

A system for planning and performing a guided and free-handed transperineal prostate biopsy includes a transrectal ultrasound probe, an access needle configured to perforate a perineal access site of a patient, a biopsy gun, and a guide. The guide includes a sliding platform, stabilization bars, upper and lower mounts, and fasteners. The system and guide apparatus is used for locating a target area using the ultrasound probe, positioning the ultrasound and the access needle at respective designated points, precisely measuring the distance to a designated point, and obtaining specimens from a precise point in the prostate, wherein the method is performed free-handed, and multiple tissue or cell specimens may be obtained from the prostate through an initial access needle. (26316225 1):AWB ...

Frostbite prevention pad for cryolipolysis procedure

The technical objective of the present invention is to provide a frostbite prevention pad for a cryolipolysis procedure, the pad being capable of preventing waterproof members from being torn while sound pressure is formed or the waterproof members and a base member from being separated from each other, and capable of easily coupling the waterproof members to the base member without defects. To this end, the frostbite prevention pad for a cryolipolysis procedure is used for a cryolipolysis procedure using a cryolipolysis device, and comprises: a base member made of a fiber material; one or more waterproof members made of resin, and overlapped on the base member; and one or more sewing parts formed by being backstitched such that the base member and the waterproof members are coupled to each other in the overlapped state.

Hand-held cryosurgical probe system

Cryosurgical probe with disposable sheath

HEAT EXCHANGER FOR CRYOSURGICAL TOOLS

Methods and Devices for Selective Disruption of Fatty Tissue by Controlled Cooling

Systems, methods and devices for a skull/brain interface

Methods for localized intra-body treatment of tissue

Methods and systems for cryogenic cooling

Methods and devices for accessing and delivering devices to a heart

Described here are devices, methods, and systems for accessing and delivering devices to a heart. Systems used to provide access to the heart via the left atrial appendage comprise a first access element with a first alignment member, a second access element with a second alignment member, a piercing element, an exchange element and may further comprise a left atrial appendage stabilization device. Methods of accessing and delivering devices to the heart via the left atrial appendage may comprise advancing a first access element into the left atrial appendage by an intravascular pathway and advancing a second access element towards the left atrial appendage through the pericardial space. The first and second alignment members form an attachment through the wall of the left atrial appendage so that the first and second access elements are aligned.

Methods and devices for treating atrial fibrillation

Described here are systems and methods for affecting tissue within a body to form a lesion. Some systems comprise tissue-affecting devices, devices that guide the advancement of the tissue-affecting elements to a target tissue region, devices that locate and secure tissue, and devices that help position the tissue-affecting devices along the target tissue. The methods described here comprise advancing a first tissue-affecting device to a first surface of a target tissue, advancing a second tissue-affecting device to a second surface of the target tissue, and positioning the first and second devices so that a lesion may be formed in the tissue between them. In some variations, the devices, systems, and methods described here are used to treat atrial fibrillation by ablating fibrillating tissue from an endocardial surface and an epicardial surface of a heart. Methods of closing, occluding, and/or removing the left atrial appendage are also described.

System and method for reconstructing cardiac activation information

An example system and method of reconstructing cardiac activation information are disclosed. A first cardiac signal and a second cardiac signal are processed via a computing device to determine whether there is a point of change in a derivative of the first cardiac signal with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define cardiac activation indicating a beat in the first cardiac signal if it is determined that the point of change is above the threshold.

Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves

A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating cardiac arrhythmias, particularly atrial fibrillation includes the insertion of an ablation catheter into the lumen of a renal artery. The ablation catheter is equipped with an electrode that can stimulate the wall tissue in the renal artery to help identify the location of a renal nerve. High-frequency stimulation of the renal nerve causes a decrease in the blood pressure of the patient thereby indicating that a renal nerve is nearby. The ablation catheter is used to ablate the renal nerve using radiofrequency, ultrasound, microwave energy or cryogenic cooling. An irrigated ablation catheter may be used to decrease damage to cells in the wall of the lumen of the renal artery other than the renal nerve, such as the endothelial cells. In order to treat atrial fibrillation an ablation catheter would be used to isolate one or more pulmonary veins in order to reduce propagation of the aberrant ...

Method and apparatus for heating during cryosurgery

METHOD FOR TREATING CERVICAL CANCER

Method and Apparatus for Delivering a Lead to a Heart

A method and apparatus for creating and accessing an anatomic space between a heart and a pericardial sac. The apparatus includes a catheter having a cryoadhesion member situated on the distal tip of the catheter. The cryoadhesion member is utilized to adhere to the pericardial sac and to retract the sac to create a tent like structure. The catheter allows introduction of an instrument to access the pericardial sac by puncture. The access to the pericardial sac allows delivery of a device, a drug, a biologic or other substance to the heart or the space around the heart.

Guided procedural treatment device and method

A medical device for minimally invasive surgical procedures. The medical device includes an ablative probe for removing malignant tissues from a body. A guidance sleeve encapsulates the ablative probe and facilitates its advancement through an opening in the body. In addition, the device includes an imaging device for monitoring the position of the guidance sleeve and the ablative probe within the body.

Catheter with coronary sinus ostium anchor

A method of treating cardiac tissue is provided, including positioning a first chamber of a medical device adjacent an atrial wall; directing a cryogenic coolant into the first chamber; anchoring the first chamber to the atrial wall through cryoadhesion; directing a distal portion of the medical device into the coronary sinus; and positioning a cardiac lead through at least a portion of the coronary sinus with the distal portion. The method may include measuring a temperature of the first chamber; removing the first chamber from the atrial wall once a predetermined threshold temperature of the first chamber is reached; anchoring a second chamber of the medical device to a portion of the coronary sinus; and/or perfusing blood flow through at least a portion of the second chamber.

Electrosurgical sealing tool having haptic feedback

A surgical tool system includes an electrosurgical tool for sealing and transecting tissue and a tactile feedback system integrated onto a handle of the tool that generates relevant feedback in at least the form of haptic effects to the user. The tactile feedback alerts the user of tissue properties, i.e., when tissue located within jaws of the tool is completely sealed, when the tissue is ready to be cut, the cutting rate or speed, the quantity of tissue located within jaws of the tool, and whether a blood vessel is fully located within jaws of tool. In addition, the tactile feedback alerts the user to the operating status of energy application during the procedure.

Irrigated ablation electrode assemblies

An irrigated ablation electrode assembly comprises a distal member, a first manifold, and a second manifold. The distal member includes an outer surface; an inner surface; and at least one radially extending passageway that extends from the inner surface of the distal member to the outer surface of the distal member. The first manifold includes an outer surface, an inner cavity, and at least one radially extending passageway that extends from the inner cavity to the outer surface of the first manifold. The second manifold includes an outer surface, an inner surface, and at least one radially extending passageway that extends from the inner surface of the second manifold to the outer surface of the second manifold. Other irrigated ablation electrode assemblies are also presented.

Systems, assemblies, and methods for treating a bronchial tree

Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.

Supply device

A supply device for a surgical apparatus for operating a surgical instrument that includes a control unit for controlling the surgical instrument, a memory unit for storing configuration data, and a mediating unit for allocating an adjustment value to a mathematical function to obtain a scaling factor, and methods of using such a supply device.

Automatic quantitative vessel analysis

Apparatus and methods are described for use with an image of blood vessels of a subject. In response to a user designating a single point on the image (a) a target portion of a blood vessel is automatically identified in the vicinity of the designated point, and (b) quantitative vessel analysis is performed on the target portion of the blood vessel. An output is generated based upon the quantitative vessel analysis. Other embodiments are also described.

System and method for renal artery occlusion during renal denervation therapy

A catheter includes a flexible shaft having a length sufficient to access a patient's renal artery relative to a percutaneous access location. A treatment arrangement is provided at a distal end of the shaft and configured for deployment in the renal artery. The treatment arrangement includes an ablation arrangement configured to deliver renal denervation therapy. An occlusion arrangement is configured for deployment in the renal artery and for altering blood flow through the renal artery during or subsequent to renal denervation therapy delivery. A monitoring unit is configured for monitoring for a change in one or more physiologic parameters influenced by the renal denervation therapy. The monitoring unit is configured to produce data useful in assessing effectiveness of the renal denervation therapy based on the physiologic parameter monitoring.

Reducing risk of complications associated with tissue ablation

Methods and systems are described that reduce risks of hematologic, metabolic, and renal complications in a mammal, such as a human, undergoing tissue ablation. One such method includes inserting a probe into a mammal and ablating abnormal tissue in the mammal by emitting a first amount of energy from the probe. In some embodiments, after emitting the first amount of energy, a method can include denaturing proteins released from cells in the abnormal tissue by emitting a second amount of energy from at least one of the first probe or a second probe inserted into the mammal. Furthermore, some embodiments can be implemented such that during or after the emitting the energy from a probe, a composition is administered to the mammal in an effective amount to denature proteins released from cells in the abnormal tissue.

Apparatus and Method for Ablating Tissue

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

System and method for reconstructing cardiac activation information

An example system and method of reconstructing biological activation information are disclosed. A first biological signal and a second biological signal associated with an organ are processed via a computing device to determine whether there is a point of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold. An activation onset time is assigned in the first biological signal at the point of change to define biological activation associated with the organ in the first cardiac signal if it is determined that the point of change is above the threshold.

Ablation devices and methods of use

Described herein are various methods and devices for delivering cryoablative therapy. One such device includes a cryoablation chamber and a volume displacement chamber. In use, the volume displacement chamber can be expanded to occupy a non-therapeutic volume.

Coiled heat exchanger for cryosurgical instrument

A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger. The heat exchanger includes: a plurality of cryogen delivery tubes that spiral around a longitudinal axis thereof; and a diffuser having a plurality of branches, each of the branches supplying received cryogen to a respective one of the delivery tubes. The cryogen delivery tubes, where they spiral, are spaced from each other and in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft.

Vertebral bone navigation systems

System and methods for channeling a path into bone include a trocar having a proximal end, distal end and a central channel disposed along a central axis of the trocar. The trocar includes a radial opening at or near the distal end of the trocar. The system includes a curveable cannula sized to be received in the central channel, the curveable cannula comprising a curveable distal end configured to be extended laterally outward from the radial opening in a curved path extending away from the trocar. The curveable cannula has a central passageway having a diameter configured allow a probe to be delivered through the central passageway to a location beyond the curved path.

Vertebral Body Nerve and Vein Cauterizing System and Method

Disclosed are vertebroplasty methods that include cauterizing an inner cavity of a vertebra of a mammal, such as a human, and injecting bone cement into the vertebra. Systems and kits for performing such methods are also disclosed.

System for heating a vertebral body to treat back pain

Methods and systems for modulating intraosseous nerves (e.g., nerves within bone) are provided. For example, the methods and systems described herein may be used to modulate (e.g., denervate, ablate) basivertebral nerves within vertebrae. The modulation of the basivertebral nerves may facilitate treatment of chronic back pain.

Access and tissue modification systems and methods

Described herein are methods and systems for precisely placing and/or manipulating devices within the body by first positioning a guidewire or pullwire. The device to be positioned within the body is coupled to the proximal end of the guidewire, and the device is pulled into the body by pulling on the distal end of the guidewire that extends from the body. The device may be bimanually manipulated by pulling the guidewire distally, and an attachment to a device that extends proximally, allowing control of both the proximal and the distal ends. In this manner devices (and particularly implants such as innerspinous distracters, stimulating leads, and disc slings) may be positioned and/or manipulated within the body. Guidewire exchange systems, devices and methods are also described. A guidewire may be exchanged between different surgical devices and may be releaseably or permanently coupled.

ABLATION-BASED THERAPY FOR BLADDER PATHOLOGIES

An ablation balloon to be used for bladder diseases. The balloon is uniformly or selectively covered with physical mechanisms capable of treating various bladder pathologies such as electrodes, insulation material, material capable of local release of fluid; or material capable of protecting selected regions of the bladder; and sensors capable of sensing (when balloon surface is in contact with bladder wall, temperature, impedance, pressure; or any combination thereof); or any combination thereof 1. A method to treat bladder pathologies comprising inserting a catheter into the bladder , wherein the catheter comprises a deflated balloon , and inflating said balloon , wherein said balloon comprises physical elements capable of ablating the pathologies.2. The method of claim 1 , wherein the physical elements results in denervation of normal or non-aberrant tissues/nerves and/or aberrant tissue/nerves.3. The method of claim 1 , wherein the bladder pathologies are selected from a group consisting of bladder overactivity; interstitial cystitis claim 1 , and bladder cancer.4. The method of claim 1 , wherein said physical elements are selected from a group consisting of electrodes claim 1 , fiber optics claim 1 , cryogenic gas/liquid claim 1 , insulation material claim 1 , material capable of local release of fluid; or material capable of protecting selected regions of the bladder; and sensors capable of sensing when the balloon surface is in contact with bladder wall claim 1 , temperature claim 1 , impedance claim 1 , pressure; or any combination thereof; or any combination thereof5. The method of claim 4 , wherein said electrodes are capable of heating or cooling said bladder.6. The method of claim 1 , wherein said balloon is a high volume-low pressure balloon.7. The method of claim 1 , wherein only selective portions of the balloon have said physical elements claim 1 , and whereby the balloon is able to selectively treat specific regions of the bladder.8. The method of ...

CRYO-MEDICAL INJECTION DEVICE AND METHOD OF USE

The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment. 1. A cryotreatment pellet having a porous matrix in a rigid or semi-rigid configuration and frozen to a temperature between about −60° C. to about −196° C. , the porous matrix configured to deliver a time-released ablative dosage of temperature within a target tissue ,wherein the porous matrix remains intact as an integral unit when injected into the target tissue such that the time-released dosage of temperature destroys the target tissue at an injection site and within a designated zone of treatment.2. The cryotreatment pellet of claim 1 , wherein the porous matrix has a resorbable composition within a water soluble environment.3. The cryotreatment pellet of ...

SYSTEMS AND METHODS FOR PLANNING IMAGE GUIDED INTERVENTIONAL PROCEDURES

In some embodiments, a planning station can receive image data associated with an image(s) of an area of interest within a body of a patient and display the image(s) on a display device. A user can make a selection of a first interventional tool and a second interventional tool about which information is stored in a memory of the planning station. The planning station can execute a simulation viewable on the display device of a treatment plan for disposing the first and second interventional tools in the body of the patient and applying thermal energy from the first and second interventional tools to the body of the patient. The planning station can generate a thermal model of the thermal effect collectively produced on tissue of the patient by the first interventional tool and the second interventional tools and display the thermal model on the display device. 1. A non-transitory processor-readable medium storing code representing instructions to cause a processor to:receive image data associated with at least one image of an area of interest within a body of a patient, the area of interest including a target tissue to be treated;display the at least one image on a display device;receive an input from a user of a selection of a first interventional tool from a plurality of interventional tools about which information is stored in a memory,receive an input from the user of a selection of a second interventional tool from the plurality of interventional tools about which information is stored in the memory;execute a simulation viewable on the display device of a treatment plan including disposing the first interventional tool in a first location in the body of the patient, disposing the second interventional tool in a second location in the body of the patient, applying a first amount of energy from the first interventional tool and applying a second amount of energy from the second interventional tool to the body of the patient;generate a thermal model of the ...

SYSTEM AND METHODS FOR DESTRUCTION OF TISSUE USING CRYOGENIC FLUID

Provided are systems and methods for destroying tissue using a cryogenic fluid. The systems generally comprise a hollow outer cylinder; a hollow inner cylinder placed within the hollow outer cylinder; a tip at the front end or distal end of the outer cylinder; wherein a cryogenic fluid is made to flow through the hollow region of the inner cylinder which oozes out or flows out of more than one grooves or apertures on the surface of the inner cylinder and then passes through the hollow portion of the outer cylinder. Yet another preferred embodiment provides for a housing component having a combination of storage for additional system cooling and exhaust facilities. 1. A cryoprobe system for destroying tissue using a cryogenic fluid , said system comprising:a hollow outer cylinder and a hollow inner cylinder placed within said hollow outer cylinder, said hollow outer cylinder comprising a tip at its operative distal end, said hollow inner cylinder and said hollow outer cylinder being open at their operative proximal ends, characterised in that, said hollow inner cylinder comprising more than one grooves or apertures located near its operative distal region, said grooves or apertures being circumferential grooves or apertures in a spaced apart manner with respect to each other.2. A system as claimed in wherein claim 1 , said grooves or apertures are non-collinear grooves or apertures.3. A system as claimed in wherein claim 1 , said tip is sharp and pointed claim 1 , adapted to act as a needle for incision or insertion of said system into a desired area or portion of the body of a subject.4. A system as claimed in wherein claim 1 , tip comprising a solid interior part adapted to receive the operative distal end of said inner cylinder so that it forms a fixed substantially co-axial assembly with said outer cylinder.5. A system as claimed in wherein claim 1 , said system comprising a housing component having a combination of storage and exhaust facilities claim 1 , said ...

Methods and systems for detection and thermal treatment of lower urinary tract conditions

The invention is directed to a method for treating a urinary system. The method includes positioning one or more treatment units with respect to an organ wall. The one or more treatment units may be configured to deliver thermal energy. The method further includes delivering energy through the one or more treatment units to heat tissue of the organ wall.

Cryosurgical Fluid Supply

Improved systems, devices, and methods for delivering cryogenic cooling fluid to cryosurgical probes such as cryosurgical endovascular balloon catheters take advantage of the transients during the initiation and termination of cryogenic fluid flow to moderate the treatment temperatures of tissues engaged by the probe. A flow limiting element along a cryogenic fluid path intermittently interrupts the flow of cooling fluid, often cycling both the fluid flow and treatment temperature. This can maintain the tissue treatment temperature within a predetermined range which is above the treatment temperature provided by a steady flow of cryogenic fluid. In another aspect, room temperature single-use cooling fluid cartridges are filled with a sufficient quantity of cryosurgical fluid to effect a desired endovascular cryosurgical treatment. 1. A catheter comprising:a first lumen;a second lumen;an outer balloon defining an outer balloon chamber in fluid communication with the first lumen;an inner balloon positioned inside the outer balloon chamber, the inner balloon defining an inner balloon chamber in fluid communication with the second lumen, the inner balloon chamber being smaller than the outer balloon chamber, the inner balloon chamber being a cooling chamber.2. The catheter of claim 1 , further comprising a guidewire lumen extending through the inner balloon.3. The catheter of claim 1 , further comprising one or more ports configured to deliver a cooling fluid from the second lumen to the inner balloon.4. The catheter of claim 3 , wherein the one or more ports are radially oriented openings of a diffuser positioned inside the inner balloon chamber.5. The catheter of claim 1 , further comprising a third lumen in fluid communication with the inner balloon claim 1 , wherein the second lumen is an inflow lumen for fluid to enter the inner balloon chamber and the third lumen in an outflow lumen for fluid to exit the inner balloon chamber.6. The catheter of claim 5 , further ...

Cryosurgical system

An invention relates to the area of cryosurgical equipment. It proposes a cryosurgical system, which incorporates measuring and computing means for estimation of a real time ice ball diameter and operation temperature of a cryotip (the distal section of a cryosurgical probe). The cryosurgical probe of the cryosurgical system operates by blowing in a gaseous medium at cryogenic temperature.

Cryogenic balloon device with radiofrequency tip

An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.

Mri-guided devices and mri-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time

An MRI-guided medical device includes an elongated sheath, an elongated dilator, and an elongated needle. The sheath has a distal end, an opposite proximal end, and a central lumen extending between the proximal and distal ends. The sheath comprises MRI-compatible material and includes a tracking member located adjacent to the sheath distal end that is visible in an MRI image. The dilator comprises MRI-compatible material and is movably disposed within the sheath lumen. A distal end of the dilator is configured to extend outwardly from the sheath distal end and dilator includes at least one tracking member that is visible in an MRI image. The needle is movably disposed within the dilator lumen and is movable between stored and operative positions relative to the dilator. An RF shield may be coaxially disposed within the elongated sheath so as to surround a portion of the sheath central lumen.

MRI-GUIDED CATHETERS

An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length. 1. An MRI-compatible catheter , comprising:an elongated flexible shaft having a distal end portion, and an opposite proximal end portion;an electrical connector interface configured to be in electrical communication with an MRI scanner; andat least one RF tracking coil positioned adjacent the distal end portion of the flexible shaft, wherein the at least one tracking coil includes a conductive lead extending between the at least one RF tracking coil and the electrical connector interface and configured to electrically connect the at least one tracking coil to the MRI scanner, and wherein the conductive lead includes a series of pre-formed back and forth segments along its length.2. The catheter of claim 1 , wherein the conductive lead is a coaxial cable.3. The catheter of claim 1 , wherein the at least one RF tracking coil comprises a plurality of tracking coils claim 1 , each attached to a separate conductive lead claim 1 , and wherein each conductive lead includes a series of back and forth segments along its length.4. The catheter ...

METHODS FOR TREATING BARRETT'S METAPLASIA AND ESOPHAGEAL ADENOCARCINOMA

Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma. 1. A method for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma in a subject , the method comprising:amplifying DNA sequences from a biological specimen from the subject;detecting mutations in microsatellite regions of the amplified DNA sequences;categorizing clonality of each mutation;calculating a mutational load based on the sum of low and high clonality mutations;comparing the mutational load with a series of pre-determined mutational load cut-offs defining risk categories; andassigning the subject to a risk category corresponding to the subject's mutational load, wherein each risk category is indicative of the risk of disease progression.2. The method of claim 1 , wherein the pre-determined mutational load cut-offs defining risk categories are derived from a pre-determined patient population distribution with known mutational loads corresponding to a known disease state diagnosis.3. The method of claim 2 , wherein the known disease state diagnosis is selected from normal squamous claim 2 , columnar epithelium without Barrett's metaplasia claim 2 , Barrett's metaplasia claim 2 , Barrett's metaplasia intermediate for dysplasia claim 2 , low grade dysplasia and high grade dysplasia.4. The method of claim 2 , wherein the risk categories are selected from no mutational load claim 2 , low mutational load claim 2 , and high mutational load.5. The method of claim 4 , wherein the subject is assigned to the no mutational load risk category when the subject has mutational load of 0.0.6. The method of claim 4 , wherein the wherein no mutational load is indicative of no risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma. ...

Renal neuromodulation methods and devices for treatment of polycystic kidney disease

Methods for treating polycystic kidney disease with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery of a kidney of a patient. One or more measurable physiological parameter corresponding to the polycystic kidney disease can thereby be reduced. Moreover, central sympathetic drive in the patient can be reduced in a manner that treats the patient for the polycystic kidney disease. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to cryotherapeutically cool the renal nerve or to deliver an energy field to the renal nerve.

TREATMENT OF POLYCYSTIC OVARY SYNDROME USING RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS

Methods for treating polycystic ovary syndrome with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. The polycystic ovary syndrome can be associated, for example, with a condition including at least one of oligo/amenorrhea, infertility, hirsutism, obesity, metabolic syndrome, insulin resistance, and increased cardiovascular risk profile. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery of a kidney of a patient. Central sympathetic drive in the patient can thereby be reduced in a manner that treats the patient for the polycystic ovary syndrome. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to cryotherapeutically cool the renal nerve or to deliver an energy field to the renal nerve. 1. A method of treating a human patient diagnosed with polycystic ovary syndrome , comprising:intravascularly positioning a neuromodulation assembly within a renal blood vessel of the patient and adjacent to a renal nerve of the patient;at least partially inhibiting sympathetic neural activity in nerves proximate a renal artery of a kidney of the patient; andreducing central sympathetic drive in the patient in a manner that treats the patient for the polycystic ovary syndrome.2. The method of wherein reducing central sympathetic drive in the patient in a manner that treats the patient for the polycystic ovary syndrome includes reducing expansion of claim 1 , maintaining the size of claim 1 , or reducing the size of an ovarian cyst in the patient.3. The method of wherein reducing central sympathetic drive in the patient in a manner that treats the patient for the polycystic ovary syndrome includes reducing the size of an ovarian cyst in ...

Catheter balloon methods and apparatus employing sensing elements

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

METHODS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. 1. A method for thermally-induced renal neuromodulation of a human patient , the method comprising:delivering a renal neuromodulation device to a vicinity of a neural fiber that contributes to renal function of the patient; andthermally inducing modulation of a function of the neural fiber with the renal neuromodulation device such that the neural fiber is thermally altered.2. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises directly applying thermal energy to the neural fiber.3. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises indirectly applying thermal energy to the neural fiber.4. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises delivering a thermal electric field to the neural fiber via at least one electrode.5. The method of wherein:delivering a renal neuromodulation device to a vicinity of the neural fiber further comprises intravascularly delivering the renal neuromodulation device; anddelivering a thermal electric field to the neural fiber via at least one electrode further comprises delivering the thermal electric field via at least one wall-contacting electrode.6. The method of claim 1 , further comprising monitoring a parameter of (a ...

METHODS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. 1. A method of treating a human patient diagnosed with a cardio-renal disease or disorder , the method comprising:intravascularly delivering a device to a vicinity of a neural fiber associated with renal function of the patient; andthermally inhibiting neural communication along the neural fiber with the device.2. The method of wherein thermally inhibiting neural communication along the neural fiber with the device comprises thermally inhibiting afferent neural communication along the neural fiber with the device.3. The method of wherein thermally inhibiting neural communication along the neural fiber with the device comprises thermally inhibiting efferent neural communication along the neural fiber with the device.4. The method of wherein intravascularly delivering a device to a vicinity of a neural fiber associated with renal function comprises intravascularly delivering the device via a renal blood vessel to a position proximate to the neural fiber.5. The method of wherein intravascularly delivering the device via a blood vessel to a position proximate to the neural fiber comprises intravascularly positioning the device in contact with a wall of the blood vessel proximate to the neural fiber.6. The method of wherein thermally inhibiting neural communication along the neural fiber with the device ...

CRYO-APPLICATOR CROSS-SECTION CONFIGURATION

A configuration for a cryo-catheter which optimizes both the catheter's outer diameter and the size of the catheter's internal refrigerant flow path is described. Specifically, the inner dimensions of the cryo-catheter are configured to accommodate a pre-selected flow of refrigerant into the catheter's distal tip, and a return flow of refrigerant from the distal tip. The return flow is established in the void spaces between a refrigerant supply line and the inner wall of the catheter body. The available void space varies along the catheter length and depends on the presence/absence of various catheter accessories (i.e. pull wires, pressure tubes, etc.) which typically only extend through a portion of the catheter length. The disclosed configuration ensures that the cryo-catheter does not operate in a refrigerant limited condition, maintains the refrigerant as a liquid in the supply tube, and maintains the return line pressure at about 1 atmosphere. 1. A configuration for cooling a medical device having a proximal end and a distal end , the configuration comprising:a catheter shaft including a distal segment having a distal end and a proximal end, a tip at the distal end of said distal segment, and a proximal segment attached to said distal segment, wherein said proximal segment and said distal segment define a central lumen extending through at least a portion of said catheter shaft, wherein said central lumen has a first cross-sectional area in said distal segment and a second cross-sectional area in said proximal segment, wherein the second cross-sectional area of the proximal segment is greater the first cross-sectional area; anda fluid supply line for transferring a coolant through said central lumen of said proximal segment and said distal segment to said tip;wherein a return path for a flow of coolant is defined in said central lumen by a void created between said fluid supply line and said catheter shaft, and further wherein the return path includes a first ...

Systems and methods for making and using medical ablation systems having mapping catheters with improved anchoring ability

A mapping catheter includes an elongated body for inserting into patient vasculature. A distal end of the elongated body includes a distal portion that includes a plurality of electrodes, a proximal portion disposed proximal to the distal portion, and a reduced-dimension portion disposed between the proximal and distal portions. The distal end is formed, at least in part, from a memory shape material that bends into a preformed shape upon release from a confined space. The preformed shape includes a first loop formed, at least in part, by the distal portion. The first loop is transverse to a longitudinal axis of the proximal portion. The reduced-dimension portion is configured and arranged to bend such that the reduced-dimension section advances distally through the first loop when the first loop is held in a fixed position and a force is applied distally along the longitudinal axis of the proximal portion.

METHOD AND APPARATUS FOR INFLATING AND DEFLATING BALLOON CATHETERS

A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. 1. A method of providing coolant to a medical device , the method comprising:providing a first coolant reservoir and a second coolant reservoir, wherein the first and second coolant reservoirs are in fluid communication with the medical device;transferring coolant from the first coolant reservoir to the second coolant reservoir; andtransferring coolant from the second coolant reservoir to the medical device.2. The method according to claim 1 , wherein transferring coolant from the second coolant reservoir to the medical device pressurizes the medical device to a predetermined target pressure.3. The method according to claim 2 , further comprising monitoring a pressure level within at least a portion of the medical device.4. The method according to claim 3 , further comprising evacuating coolant from the medical device when the monitored pressure level varies from the predetermined target pressure.5. The method according to claim 1 , wherein the second coolant reservoir defines a volumetric capacity substantially less than a volumetric capacity of the first coolant reservoir.6. The method according to claim 2 , wherein the second coolant reservoir has a volumetric ...

Cryogenic Probe Filtration System

A cryogenic device having a filter device fluidly connected between a valve and a cooling fluid cartridge. The filter device filters solid and fluid impurities received from the cartridge. The filter device also captures fluid impurities from the cryogenic device when not in use. 1. A cryogenic device comprising:a handpiece portion having a cryogenic coolant pathway configured to fluidly couple to a detachable needle probe; anda cartridge holder coupled to the handpiece portion and configured for removeably holding a pressurized cartridge; anda filter device coupled to the cartridge holder, the filter device having a distal filter end for fluidly coupling the filter device to the cryogenic coolant pathway and a proximal filter end for fluidly coupling to the pressurized cartridge;wherein the filter device comprises:at least one particulate filter configured to filter particulates; anda molecular filter configured to capture fluid contaminants received from the cartridge and from the coolant pathway when not in fluid communication with the cartridge.2. The cryogenic device of claim 1 , wherein each of the proximal filter end and the distal filter end includes at least one microscreen.3. The cryogenic device of claim 1 , wherein the at least one microscreen is a 2 micron screen or less.4. The cryogenic device of claim 1 , wherein the molecular filter comprises filter media.5. The cryogenic device of claim 4 , wherein the filter media comprises a plurality of molecular sieves.6. The cryogenic device of claim 5 , wherein the molecular sieves comprise pellets having pores ranging in size from 1-20 Å.7. The cryogenic device of claim 6 , wherein average pore size is 5 Å.8. The cryogenic device of claim 1 , wherein the proximal end of the filter assembly comprises a puncture coupling configured to puncture the cartridge.9. The cryogenic device of claim 1 , wherein the cartridge holder comprises a cartridge receiver affixed to the handpiece and having a cavity for holding ...

Skin Protection for Subdermal Cryogenic Remodeling for Cosmetic and Other Treatments

A cryogenic needle probe having a proximal and distal region. A cooling supply tube provides pressurized cooling fluid within the needle. The proximal region is more conductive that the distal region. The proximal region is conductively coupled to a heat source. 1. A method for cryogenically treating tissue , the method comprising:providing a needle probe shaft having a distal portion and a proximal portion, the needle probe shaft comprising a first conductivity at the distal portion and a second conductivity at the proximal portion, wherein the second conductivity is greater than the first conductivity;advancing the least one needle probe shaft into non-target tissue layered under target tissue, such that a distal portion of the needle probe shaft is positioned in the target tissue and the proximal portion of the needle probe shaft is positioned in the non-target tissue,cooling the target tissue via the distal portion of the needle probe shaft to affect remodeling of the target tissue; anddirectly conducting energy to the proximal portion of the needle probe shaft while cooling the target tissue, thereby limiting cooling of the non-target tissue.2. The method of claim 1 , wherein the non-target tissues includes skin.3. The method of claim 2 , wherein limiting cooling prevents discoloration of the skin.4. The method of claim 2 , wherein the non-target tissues includes at least a portion of subcutaneous tissue.5. The method of claim 1 , wherein cooling zones formed in the target tissue terminate proximally about a distal end of the second conductive material.6. The method of claim 1 , wherein remodeling the tissue causes nerve signal conduction disruption within the target tissue.7. The method of claim 1 , wherein the needle probe shaft comprises a first conductive material at the distal portion and a second conductive material at the proximal portion claim 1 , wherein the second material is more conductive than the first material.8. The method of claim 7 , wherein ...

Cryogenic Needle with Freeze Zone Regulation

A cryogenic needle of a cryogenic system is coupled to a heater. While the needle is inserted into target tissue beneath skin, the heater provides heat to protect the skin. Power supplied to the heater is used to interpolate performance of the needle and/or operating parameters of the cryogenic system. 1. A method for cryogenically treating tissue , the method comprising:providing a needle probe having at least one needle with a distal portion and a proximal portion, the needle probe being coupled to a coolant supply system regulated by a valve;advancing the least one needle into target tissue;regulating a valve to provide the at least one needle probe with coolant to form cooling zone in the target tissue;providing power to a heater assembly of the needle probe to protect non-target tissue;monitoring at least one characteristic of the heater while providing power to the heater;metering coolant to the needle probe using the valve based on a correlation of the monitored characteristic of the heater, such that the cooling zone is substantially maintained within an allowable size tolerance.2. The method of claim 1 , wherein the at least one monitored characteristic comprises temperature of the heater assembly.3. The method of claim 1 , wherein the at least one monitored characteristic comprises power supplied to the heater assembly.4. The method of claim 1 , wherein metering the coolant comprises regulating the valve to halt or decrease coolant flowing in the needle probe long enough for the cooling zone to decrease in size within the allowable size tolerance.5. The method of claim 1 , wherein metering the coolant comprises regulating the valve to increase coolant flowing in the needle probe long enough for the cooling zone to increase in size within the allowable size tolerance.6. The method of claim 1 , wherein the allowable size tolerance is determined by performing a tissue pre-characterization routine using the needle probe.7. The method of claim 1 , wherein ...

Ablative immunotherapy

The disclosure herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues. The immunotherapy relates to first priming patients with allogeneic cells designed to be rejected by a Th1 mediated mechanism, then inducing in situ necrosis or apoptosis in a tumor or pathogen infected lesion. Necrosis or apoptosis can be induced by methods such as cryotherapy, irreversible electroporation, chemotherapy, radiation therapy, ultrasound therapy, ethanol chemoablation, microwave thermal ablation, radiofrequency energy or a combination thereof applied against at least a portion of the tumor or pathogen infected tissue. One or more doses of allogeneic cells (e.g., Th1 cells) are then delivered within or proximate to the tumor or pathogen-infected tissue in the primed patient. The present invention provides an immunotherapeutic strategy to develop de-novo systemic (adaptive) immunity to a tumor or pathogen. 1. A therapeutic composition for treating a tumor or pathogen in a patient comprising:allogeneic cells; andantigens comprising the product of tumor necrosis or pathogen infected tissue necrosis, wherein the antigens are generated in situ, whereby the allogeneic cells and the in situ generated antigens elicit an immune response by the patient to create an anti-tumor or anti-pathogen immunity.2. The composition of further comprising a priming composition wherein the priming composition comprises allogeneic cells.3. The composition of wherein the antigens are generated in situ by ablation of the tumor or pathogen infected tissue.4. The composition of wherein the ablation is by cryoablation.5. The composition of wherein the ablation is by electroporation.6. The composition of wherein the antigens comprise tumor or pathogen antigens claim 1 , heat shock proteins and combinations thereof7. The composition of wherein the allogeneic cells are activated T-cells.8. The composition of wherein the ...

Real-Time Biomechanical Dosimetry using Optical Coherence Elastography

Methods for quantifying, adjusting or terminating a dose of a therapeutic intervention applied to tissue of a patient. A therapeutic intervention of a specified intensity is applied to a region of interest of the tissue. The tissue is mechanically excited, typically concurrently with the therapeutic intervention, and the region of interest is scanned optically or ultrasonically at the same time. An interference signal is acquired by coherently detecting post-interaction illumination arising in the region of interest by interfering the post-interaction illumination with a reference beam derived from the identical source as that of the scanning. A phase and/or amplitude of response of the tissue relative to the mechanical excitation based on the interference signal. A spatially resolved measure of a property of the region of interest is derived based on the phase of response, allowing for adjustment or termination of the therapeutic intervention. 1. A method for quantifying a dose of a therapeutic intervention applied to tissue of a human patient , the method comprising:a. applying a therapeutic intervention of a specified intensity to a region of interest of tissue of a human patient;b. mechanically exciting the tissue;c. scanning the region of interest with optical illumination derived from an optical source, concurrently with the mechanical excitation;d. acquiring an interference signal by coherently detecting post-interaction optical illumination arising in the region of interest by interfering the post-interaction optical illumination with a reference beam derived from the identical optical source;e. measuring at least one of a phase and an amplitude of response of the tissue relative to the mechanical excitation based on the interference signal;f. deriving a spatially resolved measure of a property of the region of interest based on the phase of response; andg. terminating the therapeutic intervention based at least upon the spatially resolved measure relative ...

Methods and devices for selective disruption of visceral fat by controlled cooling

The present invention provides methods and apparatus for use in the selective disruption of visceral fat tissue by controlled cooling.

Cryogenic Probe System

A cryogenic system having a base unit tethered to a handpiece connectable to a needle probe. The handpiece holds a replaceable cryogen canister assembly. The base unit connects to mains to provide power to the handpiece. The base unit includes a back-up power source in the event of interruptions of power via mains. 1. A method comprising:providing a plurality of cryogenic canister assemblies configured for sequential use with a cryogenic handpiece,wherein each canister assembly has an associated canister with a frangible seal, a housing supporting the canister, a pin supported by the housing, the canister being movable relative to the pin so as to penetrate the seal when the assembly is mounted to the handpiece, the canister assembly also having a filter assembly downstream of the pin and upstream of a port from which the fluid flows into the handpiece;mounting a first canister assembly of the plurality cryogenic canister assemblies to the handpiece;using the cryogenic handpiece mounted with the first canister assembly to remodel tissue;removing the first canister assembly thereby halting use of the cryogenic handpiece to remodel tissue and mounting a second canister assembly of the plurality cryogenic canister assemblies to the handpiece; andusing the cryogenic handpiece mounted with the second canister assembly to remodel the tissue.2. The method of claim 1 , wherein the filter assembly comprises a molecular filter.3. The method of claim 1 , wherein each canister assembly comprises a cartridge cover and a cartridge receiver.4. The method of claim 3 , wherein the cartridge cover is partially engaged with the cartridge receiver to retain the associated canister claim 3 , and wherein the cartridge cover is made to be fully engaged with the cartridge receiver before use claim 3 , thereby puncturing the canister with the pin.5. The method of claim 1 , wherein mounting the first canister assembly comprises engaging a nose cone of the first canister assembly with an ...

Devices for thermally-induced hepatic neuromodulation

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Expandable devices, rail systems, and motorized devices

Provided herein are expandable devices, rail systems, and motorized devices. In one embodiment, an expandable device comprises an expandable sac having a tool housed therein. The expandable device is optionally configured for operation while inside a body cavity. The expandable device optionally comprises at least one rail in the sac, and at least one railed device coupled to the rail for movement there on. Movement of the railed device on the rail is provided by, for example, a motor such as an electromagnetic motor or an inch-worm type motor. Expandable devices can be used, for example, to perform minimally invasive medical procedures requiring access to a body cavity. Expandable devices can also be used, for example, to provide safe and stable transport of instruments to the body cavity.

Cryogenic Ablation System and Method

A device for treating esophageal target tissue comprises a catheter, a balloon and a refrigerant delivery device. The catheter has a distal portion and a refrigerant delivery lumen. The balloon is mounted to and the refrigerant delivery device is coupled to the distal portion. The refrigerant delivery device comprises a chamber with the refrigerant delivery lumen opening into the chamber, a refrigerant delivery opening fluidly coupled to the balloon interior, and a distribution passageway fluidly coupling the chamber and the refrigerant delivery opening. A refrigerant is deliverable through the refrigerant delivery lumen, into the chamber, through the distribution passageway, through the refrigerant delivery opening and into the balloon interior so to place the balloon into an expanded, cooled state so that the balloon can press against and cool esophageal target tissue. The medical device may include means for sensing a leak in the balloon. 1. A method for making a medical device for cryogenically treating esophageal target tissue within a target tissue treatment temperature range , the method comprising:determining a target tissue treatment temperature range for cryogenically ablating the target tissue;selecting a balloon material having a glass transition temperature above the target tissue treatment temperature range, the balloon material having elastic properties above the glass transition temperature and being stretch-resistant below the glass transition temperature; andmounting a balloon made of the selected balloon material to a distal portion of a catheter assembly, the balloon comprising an inner surface defining balloon interior, the catheter assembly comprising a catheter comprising a refrigerant delivery lumen fluidly coupled to the balloon interior;whereby a refrigerant can be delivered through the refrigerant delivery lumen and into the balloon interior so to place the balloon into an expanded, cooled state with the temperature of the balloon lower ...

Apparatus and Methods For Treating Pulmonary Hypertension

A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension. 1. A method of decreasing activity of at least one sympathetic nerve , nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension , the method comprising:advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient; andusing the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.2. A method as in claim 1 , wherein advancing the treatment device comprises advancing an energy transmission device that emits energy selected from the group consisting of monopolar radiofrequency claim 1 , bipolar radiofrequency claim 1 , other forms of radiofrequency claim 1 , high intensity focused ultrasound claim 1 , low frequency ultrasound claim 1 , other forms of ultrasound claim 1 , microwave claim 1 , light claim 1 , heat claim 1 , cold radiation claim 1 , phototherapy claim 1 , magnetic claim 1 , electrical claim 1 , electromagnetic claim 1 , cryotherapy claim 1 , plasma claim 1 , mechanical claim 1 , chemical claim 1 , kinetic claim 1 , potential claim 1 , nuclear claim 1 , elastic and hydrodynamic energy claim 1 , and wherein using the treatment device comprises emitting ...

DUAL THERMAL ABLATION DEVICE AND METHOD OF USE

The invention is a multi-functional ablation device that encompasses the use of both heat energy and cryogenic energy as integrated into one medical device. In one embodiment, the medical device integrates a heat source such as RF or HIFU in combination with a source of cryogenic energy such that the multi-functional ablation device is a dual thermal ablation device capable of utilizing either energy source alone or in combination. 1. A multi-functional ablation device comprisinga hybrid thermal-cooling system comprising an electrical power supply and a cryogen source;a longitudinal body having a proximal end and a distal end wherein said proximal end includes an outer sheath having an electrical connection contained therein and connected to said electrical power supply, and wherein said distal end is a closed tip with a thermally conductive surface;an ablation zone positioned within said distal end and defined by said thermally conductive surface;a cryogen supply line disposed through said longitudinal body and interconnected with said cryogen source for generating subzero temperatures;a wall having an inner surface and an outer surface such that said inner surface creates a cryogen return lumen surrounding said cryogen supply line and said outer surface creates an insulative lumen between said wall and said outer sheath, said wall extended circumferentially through said longitudinal body; and 'wherein said ablation zone directs subzero temperatures and hyperthermic temperatures to said thermally conductive surface.', 'one or more heating elements disposed within said ablation zone of said distal end and contacting said thermally conductive surface of said closed tip, said one or more heating elements interconnected with said electrical connection of said longitudinal body for generating hyperthermic temperatures;'}2. The multi-functional ablation device of claim 1 , wherein said ablation zone is an integral unit configured for alternating use of said subzero ...

ESOPHAGEAL HEAT SENSORS

Heat sensors can be positioned within the esophagus of a patient so as to monitor temperature changes during ablation procedures in the heart. Some heat sensors can include a wire that defines an extended heat sensing region capable of detecting a change in the local temperature. Some heat sensors can be conformable to an inner surface of the esophageal wall to maintain contact therewith or to be in close proximity thereto. 1. A heat sensing assembly comprising:an electrical wire that comprises a material having a resistivity that varies with temperature; andan electrically insulating structure encapsulating the electrical wire, wherein the electrically insulating structure is configured to isolate the electrical wire from an electrically conductive substance when the heat sensing assembly is deployed, and wherein the electrically insulating structure is configured to permit heat transfer to, from, or both to and from the electrical wire,wherein the electrical wire and the electrically insulating structure are flexible about at least one axis,wherein the electrical wire extends in a longitudinal direction and in one or more lateral directions that are transverse to the longitudinal direction to define a heat sensing region when the heat sensing assembly is deployed, andwherein the heat sensing assembly is sensitive to heating occurring at a portion of the heat sensing region due to a change in a total electrical resistance of the electrical wire.2. The heat sensing assembly of claim 1 , wherein the electrically insulating structure comprises a substrate and a superstrate claim 1 , wherein the electrical wire is laminated between the substrate and the superstrate claim 1 , and wherein each of the substrate and the superstrate are flexible about the at least one axis.3. The heat sensing assembly of claim 2 , further comprising a first electrical junction and a second electrical junction claim 2 , wherein the electrical wire extends between the first and second ...

FLUIDIC ESOPHAGEAL HEAT SENSORS

Heat sensors can be positioned within the esophagus of a patient so as to monitor temperature changes during ablation procedures in the heart. Some heat sensors can include one or more fluid passageways that define an extended heat sensing region capable of detecting a change in the local temperature. Some heat sensors can be conformable to an inner surface of the esophageal wall to maintain contact therewith or to be in close proximity thereto. 1. A heat sensing assembly comprising:a support structure that is configured to extend in a longitudinal direction when positioned within an anatomical vessel of a patient; anda fluid passageway carried by the support structure and defining a heat sensing region that is configured to extend in the longitudinal direction and in one or more lateral directions that are transverse to the longitudinal direction when the heat sensing assembly is deployed within the anatomical vessel,wherein a portion of the heat sensing assembly that includes the support structure and the fluid passageway is flexible about at least one axis,wherein the support structure is configured to permit heat to pass through it to or from the fluid passageway to alter a temperature of a fluid positioned in the fluid passageway when the heat sensing assembly is deployed, andwherein the heat sensing assembly is configured to detect when a change in heat occurs at only a portion of the heat sensing region.2. The heat sensing assembly of claim 1 , wherein the fluid passageway is configured to permit flow of heat transfer fluid therein when the heat sensing assembly is in use claim 1 , and wherein the support structure is configured to permit heat from a wall of an anatomical vessel to pass through the support structure into the fluid passageway to be transferred away from the wall of the anatomical vessel via the heat transfer fluid when the heat sensing assembly is in use.3. The heat sensing assembly of claim 1 , wherein the support structure has a natural ...

SELECTIVE DELIVERY OF CRYOGENIC ENERGY TO INTERVERTEBRAL DISC TISSUE AND RELATED METHODS OF INTRADISCAL HYPOTHERMIA THERAPY

A method of delivering cryogenic energy within a vertebral body comprising forming a hole within the vertebral body; inserting a cryoprobe into said body, wherein said cryoprobe has a distal tip and a thermally transmissive region located proximate to said tip; activating said thermally transmissive region; and delivering cryogenic energy for one or more time periods in the range of 1 minute to 60 minutes. 138.-. (canceled)39. A method of delivering cryogenic energy within a vertebral body comprising:forming a hole within the vertebral body;inserting a cryoprobe into said body, wherein said cryoprobe has a distal tip and a thermally transmissive region located proximate to said tip;activating said thermally transmissive region; anddelivering cryogenic energy for one or more time periods in the range of 1 minute to 60 minutes. This application claims benefit to U.S. Provisional Application No. 60/243,702 filed Oct. 30, 2000, the entire teachings of this application being incorporated herein by reference.1. Field if the InventionThe present invention relates generally to intervertebral discs and vertebrae and methods of hypothermia therapy applied thereto to relieve pain and restore function.2. Description of the Related ArtLow back pain afflicts more than 10 million people in the United States annually. It impacts the individual sufferer's life physically, emotionally and financially, restricting his or her activities and often leading to depression and absenteeism from work. As a nation, the United States spends more than $50 billion dollars in direct and indirect medical expenses related to back pain, making it one of the leading healthcare expenditures overall.The intervertebral disc consists of the anulus fibrosus, nucleus pulposus, and the endplates of the superior and inferior vertebral bodies. The anulus and endplates contain the nucleus as the disc is pressurized during normal activities. The posterior anulus is thinner in cross-section than the anterior ...

Pain Management Using Cryogenic Remodeling

Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

CRYO-THERAPY SPRAY DEVICE

A device for cryotherapy treatment of gastrointestinal lesions includes a cooling member that may be attached to a first tube for pressurizing cryogenic fluid through the tube and into the cooling member through nozzles located at the distal end of the first tube. A second tube may be attached to the cooling member for evacuating the cryogenic fluid from within the cooling member, following the fluid's expansion once it exits the first tube. The cryotherapy device may be attached to an endoscope such that the first tube may be passed through the endoscope's working channel, while the second tube may be passed along the endoscope's circumference. The cryotherapy device may further comprise securing means attached to the first tube, for securing the first tube to the endoscope's working channel, thus preventing free rotation of the cryotherapy device within the endoscope, relative to the rotation of the endoscope. In addition, the securing means assist in maintaining a constant and known location of the nozzles relative to the distal end of the endoscope. 2. The device according to claim 1 , wherein said cooling member is a balloon.3. The device according to claim 2 , wherein said balloon is made of materials selected from a group consisting of: latex claim 2 , bio-grade polyurethane claim 2 , Polyethylene terephthalate (PET) claim 2 , and nylon elastomers.4. The device according to wherein said cooling member is a cooling finger.5. The device according to claim 4 , wherein said cooling finger is shaped to fit into cylindrically shaped lumens.6. The device according to claim 4 , wherein said cooling finger is made of materials selected from a group consisting of: stainless-steel medical grade claim 4 , titanium foil claim 4 , latex claim 4 , bio-grade polyurethane claim 4 , Polyethylene terephthalate (PET) claim 4 , and nylon elastomers.8. The device according to claim 7 , wherein said securing means comprises wings pressing against the opening of the endoscope's ...

MEDICAL INSTRUMENT AND MALE CONNECTOR FOR SAID INSTRUMENT

The medical instrument includes a male instrument connector, which includes at least one male fluid connector arranged on a flat face. A venting bore may also be arranged on the same face and disposed to act as pressure relief by which leaking fluids that accumulate in the instrument can be discharged. A cover cap may be attached to the face. The cover cap allows for sterilization of the instrument, including the male instrument connector. 1. A medical instrument , comprising:an instrument head;a supply line that comprises a fluid line for supplying a fluid and a jacket, the fluid line extending through an interior space of the jacket;a male instrument connector that has a face;a male fluid connector in fluid communication with the fluid line arranged on the face; andat least one venting opening in communication with the interior space of the jacket arranged on the face of the male fluid connector.2. The instrument of claim 1 , wherein the supply line comprises at least two fluid lines that extend through the interior space of the jacket claim 1 , one of the at least two lines conveying the fluid to the instrument head and the another of the at least two lines conveying the fluid away from the instrument head.3. The instrument of claim 1 , wherein the supplied fluid is at a pressure that is greater than ambient pressure.4. The instrument of claim 2 , wherein at least two male fluid connectors are arranged on the face claim 2 , the at least two male fluid connectors communicating with the at least two fluid lines and being aligned parallel to each other and at a right angle relative to the face.5. The instrument of claim 4 , wherein each of the at least two male fluid connectors have the same configuration as each other of the at least two male fluid connectors.6. The instrument of claim 4 , wherein the at least one venting opening is located between two of the at least two male fluid connectors.7. The instrument of claim 1 , wherein the supply line is flexible.8. ...

COMPLIANT BALLOON CATHETER

A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes. 1. A medical device comprising:a first expandable membrane having a first burst pressure mean average and a first standard deviation value, the first burst pressure mean average and first standard deviation value defining a first probability distribution curve including an upper burst pressure and a lower burst pressure;a second expandable membrane having a second burst pressure mean average and a second standard deviation value, the second burst pressure mean average and second standard deviation value defining a second probability distribution curve including an upper burst pressure and a lower burst pressure; andthe upper burst pressure of the first probability distribution curve being less than the lower burst pressure of the second probability distribution curve.2. The medical device of claim 1 , further ...

SURGICAL CATHETER HAVING SIDE EXITING MEDICAL INSTRUMENT AND RELATED SYSTEMS AND METHODS FOR FOUR DIMENSIONAL SOFT TISSUE NAVIGATION

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient, wherein the surgical instrument, as provided, may be a steerable surgical catheter with a biopsy device and/or a surgical catheter with a side-exiting medical instrument, among others. Additionally, systems, methods and devices are provided for forming a respiratory-gated point cloud of a patient's respiratory system and for placing a localization element in an organ of a patient. 1. A surgical catheter for navigated surgery , comprising:an elongate flexible shaft having a proximal end portion, an opposite distal end portion, a longitudinal axis, a side exit in the distal end portion, and an outer wall extending from the proximal end portion to the distal end portion;a handle attached to the proximal end portion;an electromagnetic localization element at the distal end portion; anda medical instrument housed within the elongate flexible shaft that is extendable along a path from a position within the outer wall and through the side exit to an extended position outside the outer wall, the medical instrument being disposed at an angle of at least 10 degrees relative to the longitudinal axis at the side exit when in the extended position, wherein the position of the medical instrument along the path can be calibrated to the location of the electromagnetic localization element and displayed by a surgical instrument navigation system.2. The surgical catheter of wherein the elongate flexible shaft comprises a steering mechanism comprising a steering actuator at the proximate end portion and a pull wire connected to the steering actuator wherein the distal end portion may be moved relative to the proximal end portion by manipulating the steering actuator to apply a tension to the pull wire.3. The surgical catheter of wherein an arc of at least 20 degrees may ...

REGULATING INTERNAL PRESSURE OF A CRYOTHERAPY BALLOON CATHETER

A method of performing a cryotherapy procedure can include introducing a cryotherapy balloon catheter at a treatment site inside a patient's body; regulating, during a first phase of a cryotherapy procedure, flow of cryogenic fluid to and exhaust from a distal balloon portion of the cryotherapy balloon catheter to cause an initial pressure to be maintained inside the distal balloon portion that is sufficiently high to cause an outer wall of the distal balloon portion to be pressed against body tissue at the treatment site; and regulating, during a second phase of the cryotherapy procedure, flow of cryogenic fluid to and exhaust from the distal balloon portion to cause a) a temperature inside the distal balloon portion to reach a value sufficient to deliver therapeutic levels of cryotherapy to the body tissue, and b) a second-phase pressure to be maintained that is within a threshold value of the initial pressure. 1. A method of operating a cryotherapy balloon catheter , the method comprising:providing a cryotherapy balloon catheter with a controller;regulating with the controller, during a first phase, a pressure source to inflate a first distal balloon portion of the cryotherapy balloon catheter, independently of a release of cryogenic fluid into the first distal balloon portion, to develop a first pressure inside the first distal balloon portion;starting a flow of cryogenic fluid to the first distal balloon portion and a corresponding flow of exhaust from the first distal balloon portion; andregulating with the controller, during a second phase, flow of cryogenic fluid to and exhaust from the first distal balloon portion to a) cause a temperature inside the first distal balloon portion to reach a value sufficient to deliver therapeutic levels of cryotherapy, and b) maintain a second-phase pressure that is within a threshold value of the initial pressure.2. A cryotherapy catheter comprising:an elongate member and an inflatable balloon at a distal end of the ...

Cryotreatment device and method

Devices and methods for cooling vessel walls to inhibit restenosis in conjunction with medical procedures such as coronary artery angioplasty. One catheter device includes a distal tube region having coolant delivery holes radially and longitudinally distributed along the distal region. In some devices, holes spray coolant directly onto the vessel walls. In other embodiments, a balloon or envelope is interposed between the coolant and the vessel walls and the coolant returned out of the catheter through a coolant return lumen. Some direct spray devices include an occlusion device to restrict blood flow past the region being cooled. Pressure, temperature, and ultrasonic probes are included in some cooling catheters. Some cooling catheters are coiled perfusion catheters supporting longer cooling periods by allowing perfusing blood flow simultaneously with vessel wall cooling.

Cryosurgery System

A cryosurgery system for application of medical-grade liquid nitrogen to a treatment area via a small, low pressure, open tipped catheter. The system includes a console, including a touch panel computer, a cryogen module , a suction module and an electronics module, and a disposable spray kit. Features include optional low cryogen flow setting to reduce the cryogen flow rate by 50%, improved cryogen flow consistency reducing pressure pulses and peaks, an integrated suction pump for improved consistency and self-checks, specified vent tube areas and corresponding maximum expected pressures during cryospray procedure; optional pressure sensing capability to monitor pressure during a treatment, and novel catheter designs of multilayer and flexible construction providing a variety of spray patterns. 1. A cryosurgical apparatus for cryogenic spray treatment comprising:a cryogen tank;a cryogen pressure maintenance system;a cryogen level monitoring system;a cryogen tank fill system;a catheter attachment apparatus;a fluid path pre-cool function;user-control system for user-control of cryogen flow;a display screen; andan on-board control system comprising a computer readable medium containing computer readable instructions for monitoring and controlling cryogen tank fill operation; running pre- procedure system checks; controlling fluid path pre-cool; and controlling thermal functions during user treatment of patients.2. An apparatus according to claim 1 , further comprising a fluid path defrost system.3. An apparatus according to claim 1 , further comprising a cryogen pressure monitoring system.4. An apparatus according to claim 1 , further comprising an on-board suction apparatus.5. An apparatus according to claim 1 , wherein said on-board control system further comprises apparatus for adjusting cryogen pressure.6. An apparatus according to claim 1 , wherein said on-board control system further comprises apparatus for controlling fluid path defrost.7. An apparatus ...

METHOD FOR TREATING AN ASTHMA ATTACK

An embodiment of the invention includes a method for decreasing resistance to airflow within a bronchial tree of a subject. The method may include the step of moving an intraluminal device along a lumen of an airway of a bronchial tree, where the intraluminal device includes an expandable member and an energy emitter. The method also may include damaging nerves along the airway using the intraluminal device without destroying an inner surface of an airway wall disposed radially between the intraluminal device and the nerves. 1. A method for decreasing resistance to airflow within a bronchial tree of a subject , the method comprising:moving an intraluminal device along a lumen of an airway of the bronchial tree, the intraluminal device comprising an expandable member and an energy emitter; anddamaging nerves along the airway using the intraluminal device without destroying an inner surface of an airway wall disposed radially between the intraluminal device and the nerves.2. The method of claim 1 , wherein damaging nerves along the airway comprises destroying nerve tissue at a position that is within at least one of the left and right lung of the subject.3. The method of claim 1 , wherein damaging nerves along the airway comprises destroying at least one nerve at a position that is within a left lung or a right lung.4. The method of claim 1 , wherein damaging nerves along the airway comprises destroying nerve tissue adjacent to the airway wall.5. The method of claim 1 , wherein damaging nerves along the airway includes damaging nerve tissue extending along a tubular section of the airway wall so as to prevent nervous system signals transmitted along the airway wall from traveling past the damaged portion.6. The method of claim 1 , wherein the airway comprises a bronchus.7. A method for decreasing resistance to airflow within a bronchial tree of a subject claim 1 , the method comprising:moving an intraluminal device along a lumen of an airway of the bronchial tree, the ...

TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. 1. A treatment system for removing heat from subcutaneous lipid-rich cells of a region of a subject , comprising: a chamber configured to receive target tissue of the region,', 'at least one treatment interface, and', "at least one thermoelectric cooling element operatively coupled to the at least one treatment interface and configured reduce a temperature of the region such that lipid-rich cells in the target tissue of the region are damaged while non-lipid-rich cells in the subject's epidermis and/or dermis are generally not injured; and"], 'a cooling device including'}a suction unit configured to be coupled to the cooling device and to thereafter be activated to draw air from the chamber such that the target tissue is pulled into the chamber and into contact with the at least one treatment interface.2. The treatment system of wherein the at least one treatment interface is configured to surround the target tissue in the chamber.3. The treatment system of wherein the cooling device is configured to stretch the subject's skin to decrease a thickness of the subject's epidermis and/or dermis.4. The treatment system of claim 1 , further comprising at least one detector configured to monitor a temperature of the at least one treatment interface.5. The treatment system of wherein the at least one thermoelectric cooling element is configured to maintain an average temperature in a range of about −15° C. to about 5° C.6. The treatment system of claim 1 , further comprising a temperature monitor.7. The treatment system of claim 6 , further comprising a control unit configured to receive temperature information from the temperature monitor.8. The treatment system of wherein activation of the suction unit ...

SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS AND SYSTEMS FOR REMOVING HEAT FROM A TARGET TISSUE MASS

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. 1. A system for removing heat from subcutaneous lipid-rich cells of a region of a subject , the system comprising a treatment system including at least one cooling/heating element and configured to wrap around at least a portion of the subject such that the system is capable of reducing a temperature of the region to damage the subcutaneous lipid-rich cells while not injuring non-lipid-rich cells proximate to the at least one cooling/heating element.2. The system of wherein the treatment system is configured to at least partially surround one or more selected from the group consisting of:an arm, an upper or lower leg, and a waist of the subject.3. The system of wherein the treatment system is configured to form a band or cylinder around the portion of the subject.4. The system of wherein the portion of the subject includes one or more selected from the group consisting of: an arm claim 1 , an upper or lower leg claim 1 , and a waist of the subject.5. The system of wherein the treatment system comprises a flexible material that allows the treatment system to wrap around the portion of the subject.6. The system of wherein the treatment system includes a fastening mechanism that couples together ends of the treatment system.7. The system of wherein the at least one cooling/heating element includes a plurality of cooling/heating elements arranged circumferentially about the portion of the subject when the treatment system wraps around the portion of the subject.8. The system of wherein the treatment system includes at least one passage through which a fluid is capable of flowing to change the temperature of the subcutaneous lipid-rich cells.9. The system of wherein the fluid comprises a cooling/ ...

TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS AND TREATMENT SYSTEMS FOR AFFECTING SUBCUTANEOUS LIPID-RICH CELLS

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. 1. A treatment system for removing heat from subcutaneous lipid-rich cells of a subject having skin , comprising:a fluid source configured to supply heating/cooling fluid; anda treatment device configured to be in thermal communication with the subcutaneous lipid-rich cells and coupled to the fluid source such that the heating/cooling fluid flows through the treatment device to damage the subcutaneous lipid-rich cells while non-lipid-rich cells in the subject's epidermis and/or dermis are generally not injured.2. The treatment system of wherein the treatment device includes at least one heating/cooling element through which the heating/cooling fluid flows to transfer heat from the subject to the heating/cooling fluid.3. The treatment system of wherein the at least one heating/cooling element includes a network of passages through which the heating/cooling fluid flows.4. The treatment system of wherein the treatment device is configured to receive the heating/cooling fluid through an input and to expel the heating/cooling fluid through an output.5. The treatment system of wherein the fluid source is configured to re-cool the heating/cooling fluid expelled by the treatment device.6. The treatment system of claim 1 , further comprising a control unit in communication with the fluid source and programmed to control delivery of the heating/cooling fluid.7. The treatment system of wherein the control unit is configured to control the delivery of the heating/cooling fluid based on temperature information from the fluid source and/or an element of the treatment device through which the heating/cooling fluid flows.8. The treatment system of claim 6 , further comprising a detector coupled to the control ...

TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. 1. A treatment system for removing heat from subcutaneous lipid-rich cells in a target region of a subject , comprising:a treatment unit configured to produce an energy field in the subject's tissue and including a cooling/heating element configured to reduce a temperature of the target region such that the subcutaneous lipid-rich cells are damaged while non-lipid-rich cells of the subject are generally not injured.2. The treatment system of wherein the treatment unit is configured to produce at least one of a substantially constant electric field or a substantially constant acoustic field.3. The treatment system of wherein the treatment unit is configured to produce at least one of an oscillating electric field or an oscillating acoustic field.4. The treatment system of wherein the treatment unit is configured to produce the energy field that reduces or eliminates crystal formation in the subject's tissue while the treatment unit removes heat from the subcutaneous lipid-rich cells.5. The treatment system of wherein the cooling/heating element includes a passage through which fluid circulates.6. The treatment system of wherein the cooling/heating element includes a thermoelectric cooling element.7. The treatment system of claim 1 , further comprising a feedback mechanism configured to provide acoustical measurements claim 1 , optical measurements claim 1 , and/or mechanical measurements.8. The treatment system of claim 1 , further comprising a feedback mechanism configured to monitor crystal formation in the subcutaneous lipid-rich cells.9. The treatment system of wherein the feedback mechanism is operable to provide at least one of ultrasound imaging claim 8 , acoustical measurements claim 8 , ...

MAPPING AND ABLATION OF NERVES WITHIN ARTERIES AND TISSUES

Method and systems for ablating nerves including measurement of physiological parameters and/or electrical conduction. The method may include ablating nerves within an artery of a patient such as the renal artery and may include advancing a catheter into the artery, measuring a physiological parameter, emitting an electrical pulse into a wall of the artery, measuring the physiological parameter during or after the step of emitting the electrical pulse, ablating the artery wall, then repeating the steps of measuring the physiological parameter, emitting an electrical pulse, and measuring the physiological parameter during or after the step of emitting the electrical pulse. The change in the physiological parameter caused by the electrical pulse before ablation may be compared to the change in the physiological parameter caused by the electrical pulse after ablation to determine the degree of nerve ablation achieved and whether or not to perform further ablation. 1. A method of ablating nerves within an artery of a patient comprising:a) advancing a catheter into the artery to a first location, the catheter comprising a first stimulation electrode and an ablation element;b) measuring a physiological parameter of the patient;c) after step b, emitting an electrical pulse from the first stimulation electrode into a wall of the artery at the first location;d) measuring the physiological parameter during or after step d);e) ablating the artery wall at the first location after step d);h) after step e), measuring the physiological parameter of the patient at the first location;i) after step h), emitting an electrical pulse from the first electrode at the first location; andj) after step i), measuring the physiological parameter during or after step i).2. The method of wherein the physiological parameter comprises blood velocity in the artery or artery diameter at the first location.3. The method of wherein the catheter further comprises a blood velocity sensor.4. the method ...

Haptic system for balloon tipped catheter interventions

Embodiments of this invention include hand-held handles and systems for balloon-tipped catheter interventions that enable a user to appreciate a combination of palpable sensations as though his or her hand is actual anatomic tissue in situ in real time. The system may include a haptic handle coupled to the proximal end of the catheter where the haptic handle includes a balloon-shaped haptic interface that exhibits geometric characteristics reflecting an anatomy of the interventional balloon and provides tangible sensations representative of tissues surrounding the interventional balloon. Multiple sensors and actuators may be used to create a non-virtual, transparent experience communicated to a user with a three dimensional, volumetric haptic display. In one embodiment, the sensors are positioned about or within an inflatable balloon positioned at the distal aspect of an inserted catheter used to treat cardiac and vascular diseases such as coronary or peripheral vascular occlusion and ablation of cardiac tissue.

METHODS AND DEVICES FOR COOLING SPINAL TISSUE

Methods, systems, and devices are disclosed for cooling tissue, and in particular for applying therapeutic hypothermia to the spinal canal, tissue disposed within the spinal canal, and nerve roots extending from the spinal canal. Bone screws, intervertebral implants, stabilization rods, spinous process spacers, and other devices are described which define a chamber through which a chilled fluid, expandable gas, or other coolant means can be circulated, delivered, or activated to cool adjacent tissue. The degree of cooling can be regulated using a controller, which can be configured to increase or decrease the cooling effect based on any of a variety of measured or predicted physiological or thermodynamic properties. Methods are disclosed for implanting cooling instruments and for carrying out various treatment regimens that involve cooling tissue using such instruments. 178-. (canceled)79. A method for cooling tissue , comprising:implanting a disc replacement member in a disc space between a first vertebra and a second vertebra such that the disc replacement member stabilizes the first and second vertebrae; andcooling the disc replacement member to cool tissue in a spinal canal adjacent to the disc space.80. The method of claim 79 , wherein cooling the disc replacement member comprises delivering a pressurized gas to a chamber formed within the disc replacement member.81. The method of claim 79 , wherein cooling the disc replacement member comprises delivering a cooled fluid to a chamber formed within the disc replacement member and withdrawing the cooled fluid from the chamber through an exhaust conduit.82. The method of claim 79 , further comprising dynamically controlling the cooling of the disc replacement member such that a degree of cooling can be increased and decreased.83. The method of claim 82 , wherein said controlling comprises increasing or decreasing at least one of a rate of fluid flow through the disc replacement member and a temperature of fluid ...

APPARATUS AND METHODS FOR UNIFORMLY DISTRIBUTING COOLANT WITHIN A CRYO-ABLATION DEVICE

Apparatus and methods for uniformly distributing coolant within a cryo-ablation device. A nozzle apparatus includes a tubular member having a plurality of angled apertures that induce swirling of coolant streams dispersed through the angled apertures. Coolant swirling round the tubular member and along an inner surface of an inflatable balloon element inflates the balloon element and cryogenically ablate tissue. The swirling action achieved using angled apertures uniformly distributes coolant along the inner surface of the balloon such that the temperatures along an inner surface of the balloon element and ablation of tissue adjacent to the balloon element are substantially uniform. 1. A nozzle apparatus for distributing coolant within a cryo-ablation device , comprising:a tubular member having an inner surface and an outer surface, the inner surface defining a lumen through which coolant may flow, the tubular member defining a plurality of angled apertures extending between the inner and outer surfaces, wherein two or more of the angled apertures are formed within a single cross-sectional plane at a first location such that coolant flowing through the lumen is dispersed from the tubular member through the plurality of apertures in a spiral at the first location and into a space defined by the cryo-ablation device.2. The nozzle apparatus of claim 1 , where in two or more angled apertures are formed within a single cross-sectional plane at a second location spaced axially from the first location such that coolant flowing through the lumen is dispersed from the tubular member through the plurality of apertures in a first spiral at the first location and a second spiral at the second location along the tubular member.3. The nozzle apparatus of claim 1 , the tubular member being configured to uniformly distribute coolant within a substantially annular band at the first location within the cryo-ablation device.4. The nozzle apparatus of claim 1 , wherein the tubular ...

APPARATUS AND METHODS FOR CRYOGENICALLY ABLATING TISSUE AND ADJUSTING CRYOGENIC ABLATION REGIONS

Apparatus and methods for performing cryogenic ablation of tissue and adjusting the size and/or location of a cryogenic cooling region. A cooling assembly may include tubes for dispensing and exhausting a coolant or refrigerant. One or both of the tubes may be moved, e.g., slidably adjusted, in order to adjust the location or size of a cryogenic ablation region. The cooling assembly may be integrated into cryogenic ablation devices including a cryogenic balloon device that includes an inner inflatable balloon and another balloon that is at least partially wrapped around the inner balloon and carries refrigerant for performing cryo-ablation. Electrodes permit electrical mapping of tissue before or after cryo-ablation to verify success of the procedure. 1. A cryogenic ablation apparatus , comprising:a support member;a flexible body extending from the support member, the flexible body defining a lumen; anda movable cooling assembly including at least a first tube positioned within and opening into the lumen of the flexible body to supply a refrigerant to the body lumen, the first tube axially movable relative to the body.2. The cryogenic ablation apparatus of claim 1 , wherein the movable cooling assembly includes a second tube positioned within and opening into the body lumen to exhaust spent refrigerant therefrom claim 1 , the second tube axially movable relative to the body.3. The cryogenic ablation apparatus of claim 2 , wherein the first and second tubes are movable together.4. The cryogenic ablation apparatus of claim 2 , wherein the first and second tubes are movable independently.5. The cryogenic ablation apparatus of claim 1 , further comprising at least a first temperature sensor disposed within a distal region of the flexible body.6. The cryogenic ablation apparatus of claim 2 , wherein the first and second tubes are disposed coaxially.7. The cryogenic ablation apparatus of claim 2 , wherein the first and second tubes are parallel to and spaced apart from ...

Therapy systems including hyperthermic energy delivery elements and cryogenic applicators and associated methods

Therapy systems for hyperthermic energy delivery and cryogenic cooling and associated methods of use. A treatment device can have a distal portion with a therapeutic assembly including an energy delivery element and a cryogenic applicator. The energy delivery element can be configured to apply therapeutically-effective hyperthermic energy to a treatment site (e.g., for neuromodulation). The cryogenic applicator can be configured to cool tissue at least proximate the treatment site.

CYROGENIC TREATMENT SYSTEMS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A tissue treatment system , comprising:an elongate probe having a distal tip and a flexible length;at least one infusion lumen positioned through or along the elongate probe, wherein the infusion lumen defines one or more openings along its length;at least one delivery lumen slidingly positioned through or along the infusion lumen, wherein translation of the delivery lumen relative to the infusion lumen controls a number of unobstructed openings along the infusion lumen; anda liner expandably enclosing the probe.2. The system of wherein the elongate probe defines an exhaust lumen for an ablative fluid.3. The system of wherein the infusion lumen and delivery lumen are in fluid communication with one another.4. The system of wherein the one or more openings along the infusion lumen are defined opposite to one another along the infusion lumen.5. The system of wherein the delivery lumen comprises a Nitinol delivery tube slidingly positioned through the infusion lumen.6. The system of wherein the elongate probe defines a plurality of patterned slots along an anterior and/or posterior surface.7. The system of wherein the elongate probe is configured to bend within a single plane via the one or more slots.8. The system of further comprising a reservoir of a ...

Subdermal Tissue Remodeling Using Myostatin, Methods and Related Systems

Systems and methods of tissue remodeling or altering a surface of a skin of a patient are provided. A method includes increasing myostatin activity in a target tissue. Methods can include increasing myostatin activity in a target tissue in addition to various tissue remodeling techniques, including cryogenic cooling of target tissue for tissue remodeling.

Devices for killing tumor cells and related systems and methods

Various devices, systems, and methods are capable of killing tumor cells by delivering cell-disrupting agents into a tumor in an inward direction from a peripheral border about the tumor. In some examples, a covering that includes one or more emissive elements encompasses at least a portion of a tumor such that the emissive element is directed inwardly toward the tumor so as to be able to introduce a cell-disrupting agent into the tumor. In further examples, the covering is incorporated into a glove.

Methods and Devices for Cryogenic Carotid Body Ablation

Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. 1. A cryo-ablation catheter adapted to be advanced towards a bifurcation of an internal carotid artery and an external carotid artery , comprising:a first arm configured to engage with a wall of the internal carotid artery delimiting a carotid septum, and a second arm configured to be simultaneously engaged with a wall of the external carotid artery delimiting the carotid septum, the first and second arms configured to carry a cryogen fluid to ablate at least a portion of the carotid septum.2. The catheter of wherein the first arm includes a delivery lumen in fluid communication with a return lumen claim 1 , the delivery and return lumens extending through the catheter.3. The catheter of wherein the first arm comprises an elastic arm coupled to the delivery and return lumens.4. The catheter of wherein the elastic arm has a preformed configuration at which it extends about 30 to about 60 degrees away from an axis of the catheter.5. The catheter of wherein the elastic arm is disposed radially outward relative to the delivery and returns lumens to allow the lumens to engage the wall of the internal carotid artery.6. The catheter of wherein the second arm includes a delivery lumen in fluid communication with a return lumen claim 1 , the delivery and return lumens extending through the catheter.7. The catheter of wherein the second arm comprises an elastic arm coupled to the delivery and return lumens.8. The catheter of wherein the elastic arm has a preformed configuration in which it extends about 30 to about 60 degrees away from a longitudinal axis of the catheter.9. The catheter of wherein the elastic arm is disposed radially outward relative to the delivery and returns lumens so allow the lumens to engage the ...

Erodible embolization material for targeted tumor cryoablation

A method of cryoablating diseased tissue is provided. The method includes providing an embolization agent. The embolization agent includes an inner core made of a first material. The inner core has a diameter less than a diameter of an opening of a target vessel. The embolization agent further includes an erodible outer shell made of a second embolization material encompassing the inner core. The erodible outer shell has an initial diameter greater than the diameter of the opening to occlude the target vessel. The method further includes occluding the opening of the target vessel with the embolization agent to reduce blood flow in the diseased tissue. The method further includes cryoablating the diseased tissue with a cryoablation probe while the target vessel is occluded by the embolization agent.

Percutaneous Methods and Devices for Carotid Body Ablation

Methods and percutaneous devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via percutaneous carotid body ablation. 1. A cryo-ablation device adapted to protect tissue , comprising:a cryo-ablation element, the cryo-ablation element configured to reduce the temperature of tissue adjacent the cryo-ablation element; anda warming element disposed distal to the cryo-ablation element, the warming element configured to increase the temperature of tissue proximate the warming element and to prevent the temperature of tissue proximate the warming element from being reduced as much as the temperature of the tissue proximate the cryo-ablation element.2. The cryo-ablation device of wherein the device further comprises a cryogen supply lumen extending through the device and configured to carry a cryogen to the cryo-ablation element.3. The cryo-ablation device of wherein the cryogen supply lumen includes an exit lumen configured to provide communication between the cryogen supply lumen and the cryo-ablation element.4. The cryo-ablation device of further comprising an exhaust lumen in fluid communication with the cryogen supply lumen.5. The cryo-ablation device of wherein the cryo-ablation element comprises an expansion chamber in communication with the cryogen supply lumen.6. The cryo-ablation device of wherein the device comprises a shaft claim 1 , and an inner surface of the shaft defines a surface of a cryo-ablation element expansion chamber.7. The cryo-ablation device of further comprising a cryo-ablation temperature sensor.8. The cryo-ablation device of wherein the temperature sensor is disposed in a cryo-ablation element expansion chamber.9. The cryo-ablation device of wherein the warming element is disposed at a distal end of cryo-ablation device.10. The cryo-ablation device of wherein cryo-ablation element and ...

Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling

The present invention generally provides improved medical devices, systems, and methods. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. 1. A method for treating tissue of a patient using a device , the device comprising a handle and a needle interface for rigidly receiving a needle , the method comprising;rigidly attaching a first needle to the needle interface of the device;inserting the first needle through a first insertion point and into a first target region of the tissue by manipulating the handle;cooling the first target region with the first needle and removing the first needle from the patient;removing the first needle from the needle interface;rigidly attaching a second needle to the needle interface;inserting the second needle through a second insertion point and into a second target region of the tissue by manipulating the handle;cooling the second target region with the second needle; andwherein the cooling of the first target region and second target region occur during a single treatment of the patient.2. The method of claim 1 , wherein the first needle and second needle have a 20 gauge needle size or smaller.3. The method of claim 2 , wherein at least one of the first needle and second needle have a 25 ...

Vertebral treatment

Methods and systems for modulating intraosseous nerves (e.g., nerves within bone) are provided. For example, the methods and systems described herein may be used to modulate (e.g., denervate, ablate) basivertebral nerves within vertebrae. The modulation of the basivertebral nerves may facilitate treatment of chronic back pain. The modulation may be performed by a neuromodulation device (e.g., an energy delivery device).

Automatic reduction of interfering elements from an image stream of a moving organ

Apparatus and methods are described for imaging a portion of a body of a subject that undergoes a motion cycle. A plurality of image frames of the portion are acquired. The image frames are enhanced with respect to a first given feature of the image frames, by (a) image tracking the image frames with respect to the first given feature, (b) identifying a second given feature in each of the image frames, and (c) in response to the identifying, reducing visibility of the second given feature in the image frames. The image frames that (a) have been image tracked with respect to the first given feature, and (b) have had reduced therein the visibility of the second given feature, are displayed as a stream of image frames. Other embodiments are also described.

CRYOABLATION APPARATUS WITH ENHANCED HEAT EXCHANGE AREA AND RELATED METHOD

A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue. 1. A cryoablation apparatus for treating tissue comprising:an elongate shaft having a distal energy-delivery section and a distal tip;at least one active lumen extending through said distal energy-delivery section for transporting a refrigerant towards the distal tip;at least one return lumen extending through said distal energy-delivery section for transporting the refrigerant away from said distal tip; wherein said distal energy-delivery section comprises a first heat exchange region and a second heat exchange region having a different heat transfer efficiency than the first heat exchange region.2. The apparatus of wherein first heat exchange region has a different surface area than the second heat exchange region.3. The apparatus of wherein the first heat exchange region is distal to the second heat exchange region and the first heat exchange region has a greater surface area than that of the second heat exchange region.4. The apparatus of wherein an outer surface of the first heat exchange region has an exterior feature selected from the group consisting of ridges claim 3 , grooves claim 3 , corrugations claim 3 , and threads.5. The apparatus of wherein the first heat exchange region has a first length claim 4 , and the first length ranges from 1 to 6 cm.6. The apparatus of ...

Accelerated mr thermometry mapping involving an image ratio constrained reconstruction

A medical apparatus ( 300, 400, 500, 600 ) comprising a magnetic resonance imaging system ( 301 ). The medical apparatus further comprises a memory ( 330 ) containing instructions ( 350, 352, 354, 456, 458, 460 ) for execution by a processor ( 324 ). Execution of the instructions cause the processor to acquire ( 102, 202 ) baseline magnetic resonance data ( 332 ) and reconstruct ( 104, 204 ) a first image ( 334 ) using the baseline magnetic resonance data. Execution of the instructions further cause the processor acquire ( 106, 212 ) undersampled magnetic resonance data ( 336 ), which is undersampled in k-space in comparison to the baseline magnetic resonance data. Execution of the instructions further cause the processor reconstruct ( 108, 214 ) a second image ( 338 ) using the undersampled magnetic resonance data and the first image. The second image is reconstructed using an image ratio constrained reconstruction algorithm ( 354 ) and to calculate ( 110, 216 ) a temperature map ( 340 ) using the second image.

DEVICES AND METHODS FOR THE TREATMENT OF TISSUE

Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes. 1. A method of treating a patient comprising:providing a system including a treatment element constructed and arranged to treat target tissue; andtreating target tissue with the treatment element;wherein the target tissue comprises tissue positioned in a portion of the gastrointestinal tract; andwherein treating the target tissue modifies at least one property selected from the group of properties consisting of secretive properties and absorptive properties of the portion of the gastrointestinal tract.2. The method of wherein the patient is being treated for a disease or disorder selected from the group consisting of Diabetes; Type-1 Diabetes; Type-2 Diabetes; hypercholesterolemia; a metabolic syndrome; celiac disease; obesity; cancer; bronchioalveolar carcinoma; cystitis; and combinations thereof.3. The method of wherein the portion of the gastrointestinal tract comprises multiple adjacent segments of the gastrointestinal tract.4. The method of wherein the target tissue treatment modifies a secretive property selected from the group consisting of quantity of secretions; material secreted; and combinations thereof.5. The method of wherein target tissue treatment causes the target tissue to be replaced with new tissue.6. The method of wherein the new tissue displays different secretive properties than the target tissue.7. The method of wherein the new tissue displays different absorptive properties than the target tissue.8. The method of wherein the new tissue comprises new mucosal cells that have migrated from at least one of the gastric mucosa or the jejunal mucosa.9. The method of wherein the target tissue ...

Hair Removal Devices and Methods

We describe devices, methods, and systems used for hair removal. In particular, we describe hair removal devices, particularly epilation devices, methods of using those devices, and systems including those hair removal devices. Our hair removal devices include, in combination, a.) at least one primary energy source that applies that energy, e.g., radio-frequency (RF), high intensity focused ultrasonic (HIFU) energy, or high intensity light, e.g., intense-pulsed light (IPL) or light from flash lamps or lasers, to the skin or to hair in a continuous, semi-continuous, or pulsed mode and b.) a hair removal component or components, such as rotary mechanical hair removal structures or epilators, that perform a mechanical hair removal step. Auxiliary treatment or control components such as comparatively lower power heaters, ultrasound devices, coolers, impedance measurement devices, etc. may also be included in the combination or used in conjunction with our combination device.

CRYOABLATION BALLOON CATHETER AND RELATED METHOD

Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue. 1. A cryoablation balloon catheter for delivering energy to a target tissue comprising:an elongate shaft having a distal section and a distal tip wherein the distal section comprises a cryoenergy delivering core;a first balloon located in the distal section and disposed about said cryoenergy delivering core, said first balloon comprising a first state having a reduced diameter, and a second state having an enlarged diameter shape and being at least partially filled with a thermally conductive liquid such that when the balloon is in the second state, and the cryoenergy delivering core is activated, cold is thermally conducted from the cryoenergy delivering core, through the thermally conductive liquid, through a first wall of the balloon, and to the tissue.2. The cryoablation balloon catheter as recited in further comprising a second balloon surrounding the first balloon.3. The cryoablation balloon catheter as recited in wherein the cryoenergy delivering core comprises a plurality of active microtubes and return microtubes.4. The cryoablation balloon catheter as recited in wherein the thermally conductive liquid is a ...

METHOD FOR TREATING CERVICAL CANCER

Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus . IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions. 17-. (canceled)8. A method of inhibiting the proliferation of a human Papillomavirus (HPV)-infected cell in an individual infected with HPV comprising administering to said individual a therapeutically effective amount of interleukin-20 (IL-20).9. The method according to wherein IL-20 is administered intravenously claim 8 , peritoneally claim 8 , intramuscularly or intralesionally.10. The method according to wherein the HPV-infected cell is located within a genital wart or lesion.11. The method according to wherein IL-20 is injected into the infected lesion or infected genital wart of the individual.12. The method according to further comprising electrocauterization claim 11 , laser claim 11 , cryotherapy claim 11 , or surgical excision of at least the genital wart or lesion infected with HPV.13. The method according to wherein IL-20 is a first therapeutic agent that is administered in conjunction with a second therapeutic agent.14. The method according to wherein the second therapeutic agent is selected from the group consisting of interferon alpha claim 13 , interferon beta claim 13 , podophyllotoxin claim 13 , podophyllin claim 13 , 5-fluorouracil claim 13 , trichloroacetic acid and imiquimod.15. The method according to wherein IL-20 is administered at a dosage of about 1 μg to about 1000 μg per kilogram body weight per day. The present application is a divisional of U.S. patent application Ser. No. 10/321,163, filed Dec. 17, 2002, which claims the benefit of U.S. Provisional Patent Application No. 60/341,783, filed on Dec. 17, 2001, both of which are herein incorporated by reference.According to the American Cancer Society, 12,800 new cases of invasive cervical cancer would be diagnosed in the United States in 1999. ...

LINER FOR CYROGENIC TREATMENT SYSTEMS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A liner configured for expansion within a uterine cavity , comprising:a flexible membrane which is configured to have a flattened shape when in an unexpanded configuration and a contoured shape which conforms to the uterine cavity when in an expanded configuration,wherein the membrane in the expanded configuration has a length which tapers from a first width to a second width which is smaller than the first width and which is sized to receive an instrument therethrough into an interior of the membrane,wherein the first width comprises a first curved portion and a second curved portion opposite to the first curved portion such that the membrane between the first and second curved portions defines a first region having a first radius,wherein the membrane proximal to the first and second curved portions further defines a second region having a second radius different from the first radius, andwherein the membrane proximal to the second region farther defines a third region having a third radius which is opposite relative to the second radius.2. The liner of wherein the membrane is configured to be pleated to facilitate folding of the membrane for deployment.3. The liner of wherein the membrane has a uniform thickness.4. The liner of wherein the membrane has ...

HANDHELD CYROGENIC TREATMENT SYSTEMS

Methods and apparatus for the treatment of ahoy cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing; elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A handheld tissue treatment system , comprising:a handle having a housing;an elongate probe having a distal tip and a flexible length extending from the handle;at least one infusion lumen positioned through or along the elongate probe, wherein the infusion lumen defines one or more openings along its length;at least one delivery lumen slidingly positioned through or along the infusion lumen, wherein translation of the delivery lumen relative to the infusion lumen controls a number of unobstructed openings along the infusion lumen;a liner expandably enclosing the probe; anda reservoir containing a cryoablative fluid or gas which is integrated into or along the housing and in fluid communication with the at least one infusion lumen.2. The system of wherein the elongate probe defines an exhaust lumen for the cryoablative fluid or gas.3. The system of wherein the infusion lumen and delivery lumen are in fluid communication with one another.4. The system of wherein the one or more openings along the infusion lumen are defined opposite to one another along the infusion lumen.5. The system of wherein the delivery lumen comprises a Nitinol delivery tube slidingly positioned through the infusion lumen.6. The system of wherein the elongate probe defines a plurality ...

PRESSURE MONITORING SYSTEMS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A tissue treatment system , comprising:a handle having a housing;an elongate probe extending from the housing and having a distal tip and a flexible length;a liner expendably enclosing the probe;at least one infusion lumen positioned through or along the elongate probe, wherein the infusion lumen defines one or more openings along its length;one or more pressure sensors within an interior of the liner; anda controller in communication with the one or more pressure sensors, wherein the controller is programmed to monitor pressure while a cryoablative fluid or gas is infused into the interior via the infusion lumen.2. The system of wherein the controller is further programmed to pause the infusion of the cryoablative fluid or gas when the monitored pressure exceeds 150 mmHg.3. The system of further comprising one or more actuatable valves in communication with the controller claim 1 , wherein the one or more actuatable valves are configured to stop the infusion of the cryoablative fluid when triggered by the controller.4. The system of wherein the one or more pressure sensors are positioned along the elongate probe for monitoring the pressure within the interior of the liner.5. The system of wherein the one or more pressure sensors are positioned near or at ...

LINER EXTRACTION METHODS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A method of withdrawing a liner from a tissue surface , comprising:positioning an elongate probe into a body cavity to be treated;expanding a liner enclosing the probe into contact against the tissue surface of the body cavity;infusing a cryoablative fluid or gas via the elongate probe and within an interior of the liner such that the tissue surface in contact with the liner is ablated;applying a negative pressure within the interior of the liner such that the liner is pulled in a normal direction away from the tissue surface.2. The method of wherein positioning an elongate probe comprises introducing the elongate probe into a uterine cavity.3. The method of wherein expanding a liner comprises infusing one or more puffs of air into the interior of the liner until the liner conforms to the body cavity.4. The method of wherein infusing a cryoablative fluid or gas comprises infusing nitrous oxide into the interior of the liner.5. The method of wherein applying a negative pressure further comprises withdrawing the cryoablative fluid or gas from the interior of the liner.6. The method of wherein applying a negative pressure further comprises ceasing infusion of the cryoablative fluid and evacuating the interior of the liner through the elongate probe.7. The ...

CATHETER DEVICE INCLUDING FLOW SENSING

Devices and methods are provided for performing an ablation procedure on tissue with flow monitoring using flow sensors. The devices include a catheter, and at least one flow sensor disposed on the catheter, and a component for applying the ablation procedure. An assessment module provides an indication of the efficacy of the ablation procedure based on the flow measurement from the flow sensor. 1. A device , comprising:a catheter;at least one flow sensor coupled to the catheter;at least one component coupled to the catheter to perform an ablation procedure on a portion of a tissue proximate to the catheter; andan assessment module coupled to the flow sensor to receive data indicative of at least one flow measurement from the at least one flow sensor and provide an indication of the efficacy of the ablation procedure based on the data indicative of at least one flow measurement.2. The device of claim 1 , further comprising:an inflatable and/or expandable body coupled to the catheter; and 'a plurality of electrodes, at least one electrode of the plurality of electrodes is a radiofrequency electrode to deliver a radiofrequency energy to a tissue proximate to the radiofrequency electrode.', 'an electronic circuit disposed on the inflatable and/or expandable body, the electronic circuit comprising a plurality of components that accommodate expanding of the inflatable and/or expandable body, the plurality of components comprising3. The device of claim 2 , wherein the plurality of components further comprises a plurality of stretchable interconnects disposed on the tissue of the inflatable and/or expandable body claim 2 , wherein the plurality of stretchable interconnects electrically couples at least one of the plurality of electrodes to an external circuit.4. The device of claim 3 , wherein the plurality of components further comprises a main bus claim 3 , and wherein the plurality of stretchable interconnects electrically couples at least one of the plurality of ...

CYROGENIC TREATMENT METHODS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A method of ablating tissue , comprising:positioning an elongate probe into a body lumen to be treated;expanding a liner enclosing the probe into contact against a tissue surface of the body lumen;infusing a cryoablative fluid through an infusion lumen along the probe and through one or more openings defined along a length of the infusion lumen;spraying the cryoablative fluid within an interior of the liner and into contact against a wall of the liner; andcooling the tissue in contact with the liner by absorbing heat from the tissue surface conducted through the liner and into the fluid such that the fluid evaporates into a gas form within the liner.2. The method of further comprising withdrawing the gas from the interior of the liner via the probe.3. The method of wherein infusing further comprises adjusting a position of a delivery lumen relative to the infusion lumen such that the one or more openings defined along the length of the infusion lumen remain unobstructed by the delivery lumen.4. The method of wherein spraying further comprises reducing a temperature within the interior of the liner to about −89° C. within 6-7 seconds after spraying.5. The method of wherein spraying further comprises spraying the fluid in a transverse or perpendicular ...

TIME-LIMITED METHODS FOR CYROGENIC TREATMENT SYSTEMS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A method of treating tissue , comprising:positioning an elongate probe into a body lumen to be treated;expanding a liner enclosing the probe into contact against the body lumen;adjusting a position of a delivery lumen relative to an infusion lumen which is positioned through or along the elongate probe such that one or more openings defined along a length of the infusion lumen remain unobstructed by the delivery lumen;infusing a cryoablative fluid or gas at a limited flow rate through the delivery lumen such that the fluid passes into the infusion lumen, through the unobstructed openings, and into contact against an interior of the liner such that a temperature within the interior of the liner drops to −89° C. within 6 to 7 seconds of introducing the fluid or gas.2. The method of wherein infusing a cryoablative fluid or gas comprises infusing at a pressure of up to 150 mmHg and for a period of time of up to 150 seconds.3. The method of wherein the infusion of the cryoablative fluid or gas is controlled via a controller.4. The method of further comprising ceasing the infusion of the cryoablative fluid or gas into the interior of the liner.5. The method of wherein prior to infusing a cryoablative fluid or gas further comprising infusing air into the ...

SELECTIVE LUNG TISSUE ABLATION

Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue. 1. A treatment apparatus for ablating a treatment site in a lung of a patient , comprising:a shaft having a proximal end and a distal end; andan energy emitting element disposed near the distal end of the shaft, wherein the energy-emitting element is configured to extend through and conform to an airway in the treatment site of the lung.2. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises an elongate coil shaped electrode.3. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises an elongate braided wire electrode.4. A treatment apparatus as in claim 1 , wherein the energy-emitting element includes an expansion element which expands the energy emitting element to conform to a shape of the airway of the treatment site.5. A treatment apparatus as in claim 4 , wherein the expansion element comprises an inflatable balloon.6. A treatment apparatus as in claim 4 , wherein the expansion element comprises a constraint which can be released to allow the expansion element to self-expand.7. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises an electrically resistive coil or a hot fluid element.8. A method for selectively ablating a treatment region in a lung comprising:advancing a treatment apparatus through an airway toward the treatment region in the lung;exchanging energy through the treatment apparatus to heat or cool the treatment region to a level which destroys tissue at the region; andprotecting adjacent regions in the lung and surrounding tissue from thermal damage by controlling pressure or temperature at the treatment region and at one or more untreated regions adjacent the treatment region.9. A method as in claim 8 , wherein the tissue is raised to a temperature in the range from 40° C. to 95° C.10. A method as in claim 8 , wherein the delivered ...

Therapeutic apparatus having insulated region at the insertion area

Apparatus and methods for insulating tissue during therapeutic procedures.

Device and method for the geometric determination of electrical dipole densities on the cardiac wall

Disclosed are devices, a systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various locations within the associated chamber of the heart.

THERAPEUTIC RENAL NEUROMODULATION FOR TREATING DYSPNEA AND ASSOCIATED SYSTEMS AND METHODS

Methods for treating dyspnea with therapeutic renal neuromodulation and associated system and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods that block, reduce, and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry therapeutic benefits for patients with dyspnea. 1. A method of treating a human patient diagnosed with dyspnea the method comprising:at least partially inhibiting sympathetic neural activity in nerves that innervate a kidney of the patient; andreducing central sympathetic, drive in the patient in a manner that treats the patient for the dyspnea.2. The method of wherein reducing central sympathetic drive in a manner that treats the patient for the dyspnea comprises reducing the patient's sensitivity to pCO.3. The method of wherein reducing central sympathetic drive in a manner that treats the patient for the dyspnea comprises altering the patient's chemoreceptor set point.4. The method of wherein reducing central sympathetic drive in a manner that treats the patient for the dypnea comprises changing the patient's gain in respiratory effort associated with increased pCO.5. The method of wherein the dyspnea is associated with a condition comprising at least one of systolic heart failure claim 1 , diastolic heart failure claim 1 , congestive heart failure claim 1 , panic disorders claim 1 , chronic lung disease claim 1 , acute lung disease claim 1 , renal disease claim 1 , deconditioning claim 1 , and hypertension.6. The method of wherein the dyspnea comprises subjective feelings of breathlessness.7. The method of wherein at least partially inhibiting sympathetic neural activity in nerves that innervate a kidney of the patient comprises ablating a renal nerve of the patient with an energy ...

TREATMENTS USING CYROGENIC ABLATION SYSTEMS

Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session. 1. A tissue treatment system , comprising:a handle having a housing;an elongate probe extending from the housing and having a distal tip and a flexible length;a liner expandably enclosing the probe;at least one infusion lumen positioned through or along the elongate probe, wherein the infusion lumen defines one or more openings along its length; anda controller which is programmed to infuse a cryoablative fluid or gas into an interior of the liner via the infusion lumen at a pressure of up to 150 mmHg and for a period of time of up to 150 seconds.2. The system of further comprising at least one delivery lumen slidingly positioned through or along the infusion lumen claim 1 , wherein translation of the delivery lumen relative to the infusion lumen controls a number of unobstructed openings along the infusion lumen.3. The system of wherein the controller is further programmed to infuse air into the interior of the liner at a pressure of up to 85 mmHg and for a period of time of up to 20 seconds prior to infusing the cryoablative fluid or gas.4. The system of wherein the controller is further programmed to detect whether the pressure within the interior of the liner remains above 40 mmHg over a period of 5 seconds to determine whether a leak is present within ...

HETEROCYCLIC INHIBITORS OF GLUTAMINASE

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention. 171-. (canceled)73. The method of claim 72 , wherein L represents CHSCH claim 72 , CHCH claim 72 , CHS or SCH.74. The method of claim 72 , wherein L represents CHCH.7574. The method of any of - claims 72 , wherein Y represents H.7675. The method of any of - claims 72 , wherein Z represents R(CO).77. The method of claim 76 , wherein each occurrence of Ris not identical.7877. The method of any of - claims 72 , wherein Rand Reach represent H.7978. The method of any of - claims 72 , wherein R claims 72 , independently for each occurrence claims 72 , represents substituted or unsubstituted arylalkyl claims 72 , heteroarylalkyl claims 72 , cycloalkyl or heterocycloalkyl.8079. The method of any of - claims 72 , wherein R claims 72 , independently for each occurrence claims 72 , represents C(R)(R)(R) claims 72 , wherein Rrepresents substituted or unsubstituted aryl claims 72 , arylalkyl claims 72 , heteroaryl or heteroaralkyl claims 72 , Rrepresents H claims 72 , and Rrepresents hydroxy claims 72 , hydroxyalkyl claims 72 , alkoxy or alkoxyalkyl.81. The method of claim 80 , wherein Rrepresents substituted or unsubstituted aryl claim 80 , arylalkyl claim 80 , or heteroaryl.82. The method of or claim 80 , wherein Rrepresents hydroxy claim 80 , hydroxyalkyl claim 80 , or alkoxy.83. The method of claim 72 , wherein L represents CHCH claim 72 , Y represents H claim 72 , Z represents R(CO) claim 72 , Rand Reach represent H claim 72 , and R claim 72 , independently for each occurrence claim 72 , represents substituted or unsubstituted arylalkyl claim 72 , heteroarylalkyl claim 72 , cycloalkyl or heterocycloalkyl.84. The method of claim 83 , wherein each occurrence of Ris identical.8584. The method of any of - claims 72 , wherein the cancer may be one or a variant of Acute ...

Ultrasound probe with integrated electronics

A hand-held ultrasound system includes integrated electronics within an ergonomic housing. The electronics includes control circuitry, beamforming and circuitry transducer drive circuitry. The electronics communicate with a host computer using an industry standard high speed serial bus. The ultrasonic imaging system is operable on a standard, commercially available, user computing device without specific hardware modifications, and is adapted to interface with an external application without modification to the ultrasonic imaging system to allow a user to gather ultrasonic data on a standard user computing device such as a PC, and employ the data so gathered via an independent external application without requiring a custom system, expensive hardware modifications, or system rebuilds. An integrated interface program allows such ultrasonic data to be invoked by a variety of such external applications having access to the integrated interface program via a standard, predetermined platform such as visual basic or c ++ .