Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

IMPLANTABLE ELECTRODE ASSEMBLY, IMPLANTABLE ELECTROCHEMICAL POWER CELLS AND IMPLANTABLE MEDICAL DEVICE ASSEMBLIES

Electrochemical power cells having an open-cell architecture for electrically powering an implantable medical device system include a first and a second electrode assembly, wherein at least one is a biocompatible hermetically sealed anode assembly (e.g., that of a lithium anode assembly). The power cell can be a biological lithium semi-fuel cell in which a bodily constituent partakes in the cell discharge reaction at the cathode as an active reagent. The active cathode reagent can be oxygen supplied from the body. In a particularly suitable application, the biological lithium semi-fuel cell provides electrical power to a cardiac pacemaker device, such as for a novel cardiac pacemaker system.

APPAREL WITH INTEGRAL HEATING AND COOLING DEVICE

A device for heating or cooling a body of a user is provided. The device includes a thermoelectric module, a heat sink thermally coupled to the thermoelectric module, a wetting material in thermal communication with the heat sink, and a controller for cycling the thermoelectric module in accordance with a duty cycle. Additionally, a method of heating or cooling a portion of a body of a user is provided. The method includes cycling electrical power to a thermoelectric module at a duty cycle, transferring heat from the thermoelectric module to a heat sink, and evaporating a liquid from a wetting material disposed on the heat sink. The evaporated liquid enters the surrounding atmosphere.

CRYOGENIC PROBE

A cryogenic probe (10') including a cold reservoir (18) having a phase change material and a removable tip in thermal communication with the cold reservoir (18). The cryogenic probe (10') is useable with a thermal charging stand, having at least a heat sink (46), which is capable of precooling the cold reservoir (18) prior to use. Heat is pumped between the cryogenic probe (10') and the thermal charging stand (22) by thermoelectric heat pumps (30, 44).

Apparel with integral heating and cooling device

A device for heating or cooling a body of a user is provided. The device includes a thermoelectric module, a heat sink thermally coupled to the thermoelectric module, a wetting material in thermal communication with the heat sink, and a controller for cycling the thermoelectric module in accordance with a duty cycle. Additionally, a method of heating or cooling a portion of a body of a user is provided. The method includes cycling electrical power to a thermoelectric module at a duty cycle, transferring heat from the thermoelectric module to a heat sink, and evaporating a liquid from a wetting material disposed on the heat sink. The evaporated liquid enters the surrounding atmosphere.

Ablation probe with peltier effect thermal control

A tissue ablation probe, system, and method are provided. The ablation probe comprises an elongated member, an ablative element mounted on the distal end of the elongated member, and at least one thermoelectric device mounted to the member in thermal communication with the ablative element. The system may include the ablation probe, thermal control circuitry for controlling the thermal effect of the thermoelectric device, and an ablation source for suppying ablation energy to the ablative element. A plurality of circumferentially distributed thermoelectric devices can be provided, so that radial tissue sectors can be selectively affected by independently controlling the thermal effect of the thermoelectric devices. In one embodiment, the thermoelectric device(s) can be used to cool a heat ablative element. In another embodiment, the thermoelectric device(s) can be used to heat an ablative element, thereby forming a heat ablative element. In still another embodiment, the thermoelectric device ...

Devices for dermatological treatment

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Control method for a one balloon fits all in automated mode

Devices, systems, and methods for maintaining cryoballoon size, cryoballoon pressure, and/or coolant flow rate based on physical characteristics of the tissue to be ablated. In one embodiment, a cryoablation system comprises: a cryoablation device, the cryoablation device including: an expandable treatment element defining an interior chamber; and a pressure sensing system at least partially within the interior chamber; a fluid flow path including at least one valve that is in communication with at least one PID device; and a control unit including processing circuitry in communication with the pressure sensing system and the at least one PID device, the processing circuitry being configured to: determine a target pressure of the expandable treatment element based on a target size of the expandable treatment element; and determine a target flow rate of coolant through the fluid flow path based on the target pressure of the expandable treatment element.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

APPARATUS AND METHODS FOR PROCEDURES RELATED TO THE ELECTROPHYSIOLOGY OF THE HEART

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Apparel with integral heating and cooling device

A device for heating or cooling a body of a user is provided. The device includes a thermoelectric module, a heat sink thermally coupled to the thermoelectric module, a wetting material in thermal communication with the heat sink, and a controller for cycling the thermoelectric module in accordance with a duty cycle. Additionally, a method of heating or cooling a portion of a body of a user is provided. The method includes cycling electrical power to a thermoelectric module at a duty cycle, transferring heat from the thermoelectric module to a heat sink, and evaporating a liquid from a wetting material disposed on the heat sink. The evaporated liquid enters the surrounding atmosphere.

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

APPAREL WITH INTEGRAL HEATING AND COOLING DEVICE

A device for heating or cooling a body of a user is provided. The device includes a thermoelectric module, a heat sink thermally coupled to the thermoelectric module, a wetting material in thermal communication with the heat sink, and a controller for cycling the thermoelectric module in accordance with a duty cycle. Additionally, a method of heating or cooling a portion of a body of a user is provided. The method includes cycling electrical power to a thermoelectric module at a duty cycle, transferring heat from the thermoelectric module to a heat sink, and evaporating a liquid from a wetting material disposed on the heat sink. The evaporated liquid enters the surrounding atmosphere.

CRYOCATHETER WITH SINGLE PHASE COOLANT FLUID COOLED THERMOELECTRIC MODULE AND CEREBRAL MEDICAL PROCEDURES EMPLOYING LOCAL ICE BALL

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about −15° C. to about −30° C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices and methods for dermatological treatment

Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.

Devices and methods for dermatological treatment

DEVICE FOR EFFECTING CHANGE IN TISSUE AT A TREATMENT SITE

A device for effecting change in tissue at a treatment site includes a housing having an aperture for receiving a user's finger, a cold plate supported by said housing for cooling the tissue at the treatment site, and at least one thermoelectric cooling semiconductor thermally coupled to said cold plate and electrically coupled to a power source. In another embodiment, the cold plate may include a surface for contacting the treatment site, and at least a portion of said cold plate including said surface may extend from said housing.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

DEVICES AND METHODS FOR DERMATOLOGICAL TREATMENT

Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.

Cryogenic probe

Device for effecting change in tissue at a treatment site

A device for effecting change in tissue at a treatment site includes a housing having an aperture for receiving a user's finger, a cold plate supported by said housing for cooling the tissue at the treatment site, and at least one thermoelectric cooling semiconductor thermally coupled to said cold plate and electrically coupled to a power source. In another embodiment, the cold plate may include a surface for contacting the treatment site, and at least a portion of said cold plate including said surface may extend from said housing.

Apparatus and methods for procedures related to the electrophysiology of the heart

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus having thermocouple elements of different electromotive potential conductively connected at a junction is introduced into the interior of the heart and a section of heart tissue is contacted with the junction. An electrical current is passed through the thermocouple elements to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool the contacted heart tissue. The effect of the cooling may be monitored and, if desired the section of heart tissue may be treated.

METHOD AND APPARATUS FOR CRYOTHERAPY AND PACING PRECONDITIONING

A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.

Lichtquelleneinheit und Projektor mit einer derartigen Lichtquelleneinheit

Lichtquelleneinheit (10) mit mindestens einer Kühlvorrichtung (30); mindestens einem Leuchtstoff (28); mindestens einer Anregungsstrahlungsquelle (14); und mindestens einem optischen Element (26), das zwischen der mindestens einen Anregungsstrahlungsquelle und dem mindestens einen Leuchtstoff (28) angeordnet ist; wobei die mindestens eine Kühlvorrichtung (30) einen Kühlkörper darstellt, wobei der mindestens eine Leuchtstoff (28) an dem mindestens einen Kühlkörper thermisch angebunden ist; und wobei das optische Element (26) als integrierendes optisches Element ausgebildet ist und derart zwischen die mindestens eine Anregungsstrahlungsquelle und den mindestens einen Leuchtstoff (28) gekoppelt ist, dass zumindest ein Teil der von der mindestens einen Anregungsstrahlungsquelle abgegebenen, in einem Akzeptanzwinkelbereich des integrierenden optischen Elements (26) einfallenden Strahlung mindestens einer inneren Reflexion in dem integrierenden optischen Element (26) unterzogen wird, bevor er ...

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

APPARATUS AND METHODS FOR PROCEDURES RELATED TO THE ELECTROPHYSIOLOGY OF THE HEART

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.

Light Source unit and projector having such a light source unit

A light source unit may include a cooling device; a luminescent substance; an excitation radiation source having a laser source; and an optical element arranged between the radiation source and the substance; wherein the cooling device constitutes a heat sink, wherein the substance is linked thermally to the heat sink; and wherein the optical element is designed as an integrating optical element and is coupled between the radiation source and the substance in such a mariner that a part of the radiation emitted by the radiation source, entering in an acceptance angle range of the integrating optical element, is subjected to an internal reflection in the optical element before it exits the optical element and strikes the substance, and that a part of the radiation emitted by the substance enters the optical element and exits the optical element as effective radiation.

Vcrrichtung und Verfahren zur dermatologischen Behandlung

Offenbart werden Verfahren zur dermatologischen Behandlung, die in einigen Ausführungsformen das Anlegen einer Vielzahl von Kühlsonden an einen Hautbereich und das Aufrechterhalten des Kontakts der Vielzahl von Kühlsonden mit dem Hautbereich über einen Zeitraum umfassen, während dessen die Distalenden der Vielzahl von Kühlsonden ein Gewebevolumen im Wesentlichen abkühlen, wodurch ein günstiger Effekt als Ergebnis der wesentlichen Abkühlung des Gewebevolumens erzielt wird, sowie Vorrichtungen zur Durchführung der Verfahren.

DEVICE

The present invention relates, in one aspect, to a medical device for sampling biological material comprising; (i) an elongate housing (12); (ii) a probe (15) for sampling the biological material slideably mounted within the elongate housing; and (iii) a current supply electrically coupled to the probe or the elongate housing (12); wherein said elongate housing (12) and said probe (15) are made from materials having different Peltier potentials such that supply of current from the current supply generates a Peltier effect between said elongate housing and said probe.

Ablation probe with peltier effect thermal control

A tissue ablation probe, system, and method are provided. The ablation probe comprises an elongated member, an ablative element mounted on the distal end of the elongated member, and at least one thermoelectric device mounted to the member in thermal communication with the ablative element. The system may include the ablation probe, thermal control circuitry for controlling the thermal effect of the thermoelectric device, and an ablation source for suppying ablation energy to the ablative element. A plurality of circumferentially distributed thermoelectric devices can be provided, so that radial tissue sectors can be selectively affected by independently controlling the thermal effect of the thermoelectric devices. In one embodiment, the thermoelectric device(s) can be used to cool a heat ablative element. In another embodiment, the thermoelectric device(s) can be used to heat an ablative element, thereby forming a heat ablative element. In still another embodiment, the thermoelectric device ...

APPARATUS AND METHODS FOR PROCEDURES RELATED TO THE ELECTROPHYSIOLOGY OF THE HEART

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.

Lichtquelleneinheit und Projektor mit einer derartigen Lichtquelleneinheit

Die vorliegende Erfindung betrifft eine Lichtquelleneinheit (10) mit mindestens einer Kühlvorrichtung (30); mindestens einem Leuchtstoff (28); mindestens einer Anregungsstrahlungsquelle mit einer Laserquelle (14); und mindestens einem optischen Element (26), das zwischen der mindestens einen Anregungsstrahlungsquelle und dem mindestens einen Leuchtstoff (28) angeordnet ist; wobei die mindestens eine Kühlvorrichtung (30) einen Kühlkörper darstellt, wobei der mindestens eine Leuchtstoff (28) an dem mindestens einen Kühlkörper thermisch angebunden ist; und wobei das optische Element (26) als integrierendes optisches Element ausgebildet ist und derart zwischen die mindestens eine Anregungsstrahlungsquelle und den mindestens einen Leuchtstoff (28) gekoppelt ist, dass zumindest ein Teil der von der mindestens einen Anregungsstrahlungsquelle abgegebenen, in einem Akzeptanzwinkelbereich des integrierenden optischen Elements (26) einfallenden Strahlung mindestens einer inneren Reflexion in dem integrierenden ...

DEVICE

The present invention relates, in one aspect, to a medical device for sampling biological material comprising; (i) an elongate housing (12); (ii) a probe (15) for sampling the biological material slideably mounted within the elongate housing; and (iii) a current supply electrically coupled to the probe or elongate housing (12); wherein said elongate housing (12) and said probe (15) are made from materials having different Peltier potentials such that supply of current from the current supply generates a Peltier effect between said elongate housing and said probe. Furthermore, the invention relates to an assembly for housing, storing, and for transporting a medical device, wherein the receptacle comprises materials having different Peltier potentials.

DEVICE

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

ABLATION PROBE WITH PELTIER EFFECT THERMAL CONTROL

A tissue ablation system comprising an elongated member, an ablative element mounted on the distal end of the elongated member, and at least one thermoelectric device mounted to the member in thermal communication with the ablative element. The system may include the ablation probe, thermal control circuitry for controlling the thermal effect of the thermoelectric device, and an ablation source for suppying ablation energy to the ablative element. A plurality of circumferentially distributed thermoelectric devices can be provided, so that radial tissue sectors can be selectively affected by independently controlling the thermal effect of the thermoelectric devices.

IMPLANTABLE ELECTRODE ASSEMBLY, IMPLANTABLE ELECTROCHEMICAL POWER CELLS AND IMPLANTABLE MEDICAL DEVICE ASSEMBLIES

Electrochemical power cells having an open-cell architecture for electrically powering an implantable medical device system include a first and a second electrode assembly, wherein at least one is a biocompatible hermetically sealed anode assembly (e.g., that of a lithium anode assembly). The power cell can be a biological lithium semi-fuel cell in which a bodily constituent partakes in the cell discharge reaction at the cathode as an active reagent. The active cathode reagent can be oxygen supplied from the body. In a particularly suitable application, the biological lithium semi-fuel cell provides electrical power to a cardiac pacemaker device, such as for a novel cardiac pacemaker system.

Implantable electrode assembly, implantable electrochemical power cells and implantable medical device assemblies

Electrochemical power cells having an open-cell architecture for electrically powering an implantable medical device system include a first and a second electrode assembly, wherein at least one is a biocompatible hermetically sealed anode assembly (e.g., that of a lithium anode assembly). The power cell can be a biological lithium semi-fuel cell in which a bodily constituent partakes in the cell discharge reaction at the cathode as an active reagent. The active cathode reagent can be oxygen supplied from the body. In a particularly suitable application, the biological lithium semi-fuel cell provides electrical power to a cardiac pacemaker device, such as for a novel cardiac pacemaker system.

Catheter with jet impingement cooled thermoelectric module

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about −15° C. to about −30° C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.

Apparel with integral heating and cooling device

A device for heating or cooling a body of a user is provided. The device includes a thermoelectric module, a heat sink thermally coupled to the thermoelectric module, a wetting material in thermal communication with the heat sink, and a controller for cycling the thermoelectric module in accordance with a duty cycle. Additionally, a method of heating or cooling a portion of a body of a user is provided. The method includes cycling electrical power to a thermoelectric module at a duty cycle, transferring heat from the thermoelectric module to a heat sink, and evaporating a liquid from a wetting material disposed on the heat sink. The evaporated liquid enters the surrounding atmosphere.

Cooling system for a catheter

A cooling device for cooling a catheter, the cooling device comprising a main cooling unit adapted for supplying the catheter with a main cooling medium and a precooling unit adapted for precooling the main cooling medium before supply of the main cooling medium to the catheter, wherein the main cooling unit comprises a cooling pathway through which a fluid is guidable as the main cooling medium, and comprising a control unit adapted for automatically controlling the main cooling unit and the precooling unit to perform a predetermined cooling procedure, wherein the control unit is adapted for activating the precooling unit before activating a supply of the main cooling medium by the main cooling unit to the catheter.

Light source unit and projector having such a light source unit

A light source unit may include a cooling device; a luminescent substance; an excitation radiation source having a laser source; and an optical element arranged between the radiation source and the substance; wherein the cooling device constitutes a heat sink, wherein the substance is linked thermally to the heat sink; and wherein the optical element is designed as an integrating optical element and is coupled between the radiation source and the substance in such a manner that a part of the radiation emitted by the radiation source, entering in an acceptance angle range of the integrating optical element, is subjected to an internal reflection in the optical element before it exits the optical element and strikes the substance, and that a part of the radiation emitted by the substance enters the optical element and exits the optical element as effective radiation.

THERMOTHERAPY APPLICATION AND CONTROL SYSTEM

Apparatus for applying thermotherapy to a part of the human or animal body comprising an applicator having a flexible enclosure in which thermal energy transfer fluid can circulate, a connector for connecting the applicator to a control system, an interface layer for providing a thermally conductive interface between the flexible enclosure and a treatment site and, an electrically conductive supporting layer for supporting the interface layer and capable of being energised by an electrical signal from the control system to improve the thermal conductivity of the interface layer. The apparatus also includes a valve unit for connecting the applicator to a control system, a heat exchanger for cooling a thermal energy transfer fluid and a control system for controlling the application of thermotherapy. The apparatus permits manipulation and control of the molecules of the interface layer and a thermal energy transfer fluid to improve the thermal energy transfer efficiency between the applicator ...

HANDPIECE ASSEMBLY FOR AN APPARATUS USED IN COSMETIC TREATMENT

A handpiece assembly 100 for an apparatus used in non-invasive cosmetic treatment, in particular, in an apparatus for non-invasive fat reduction by cold-induced lipolysis of fat cell, known as cryolipolysis, is provided. The handpiece assembly 100 includes a handle 10, provided with a control terminal 14 equipped with a user interface, the handle 10 being connectable to the treatment unit of the apparatus for cosmetic treatment by a number of fluidic and/or communication lines; a treatment head 50 configured as a cup-shaped body applicator 20 disposed between at least two cooling units 30, and an adapter 40 configured to connect the handle 10 and the treatment head 50, wherein the connection between the handle 10 and the treatment head 50 mediated by the adapter 40 is releasable.

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices for therapeutic nasal neuromodulation and associated methods and systems

A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Apparatus and methods for procedures related to the electrophysiology of the heart

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus having thermocouple elements of different electromotive potential conductively connected at a junction is introduced into the interior of the heart and a section of heart tissue is contacted with the junction. An electrical current is passed through the thermocouple elements to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool the contacted heart tissue. The effect of the cooling may be monitored and, if desired the section of heart tissue may be treated.

Cooling system for a catheter

A cooling device for cooling a catheter, the cooling device comprising a main cooling unit adapted for supplying the catheter with a main cooling medium and a precooling unit adapted for precooling the main cooling medium before supply of the main cooling medium to the catheter, wherein the main cooling unit comprises a cooling pathway through which a fluid is guidable as the main cooling medium, and comprising a control unit adapted for automatically controlling the main cooling unit and the precooling unit to perform a predetermined cooling procedure, wherein the control unit is adapted for activating the precooling unit before activating a supply of the main cooling medium by the main cooling unit to the catheter.

DEVICES AND METHODS FOR DERMATOLOGICAL TREATMENT

Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.

Cooling system for a catheter

A cooling device for cooling a catheter, the cooling device comprising a main cooling unit adapted for supplying the catheter with a main cooling medium and a precooling unit adapted for precooling the main cooling medium before supply of the main cooling medium to the catheter, wherein the main cooling unit comprises a cooling pathway through which a fluid is guidable as the main cooling medium, and comprising a control unit adapted for automatically controlling the main cooling unit and the precooling unit to perform a predetermined cooling procedure, wherein the control unit is adapted for activating the precooling unit before activating a supply of the main cooling medium by the main cooling unit to the catheter.

Directional cryoablation system

A cryoablation system is provided that can assume a directional activated state and includes a cryoablation probe and a controller. The cryoablation probe has an active region that includes a cooling compartment and an opposing heating compartment that are thermally insulated from one another to minimize energy losses therebetween such that ice is selectively and directionally formed at the target site. The cooling compartment can include a temperature sensor and an exhaust tube to guide a fluid or gas that exhibits a Joule Thomson cooling effect through the probe. The heating compartment can include a temperature sensor and a heater cartridge having a heater zone. The controller of the cryoablation system can process temperature measurement data from the sensors of the heating and cooling compartments and regulate the heater zone based on the temperature measurement data processing to maintain a temperature that is sufficiently constant to mitigate or prevent formation of ice on the heating ...

THERMOTHERAPY APPLICATION AND CONTROL SYSTEM

Apparatus for applying thermotherapy to a part of the human or animal body comprising an applicator having a flexible enclosure in which thermal energy transfer fluid can circulate, a connector for connecting the applicator to a control system, an interface layer for providing a thermally conductive interface between the flexible enclosure and a treatment site and, an electrically conductive supporting layer for supporting the interface layer and capable of being energised by an electrical signal from the control system to improve the thermal conductivity of the interface layer. The apparatus also includes a valve unit for connecting the applicator to a control system, a heat exchanger for cooling a thermal energy transfer fluid and a control system for controlling the application of thermotherapy. The apparatus permits manipulation and control of the molecules of the interface layer and a thermal energy transfer fluid to improve the thermal energy transfer efficiency between the applicator and a treatment site.

METHOD OF SAFELY USING CONTROLLED COOLING SYSTEMS AND DEVICES

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices and methods for dermatological treatment

Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.

Cryocatheter with single phase coolant fluid cooled thermoelectric module and cerebral medical procedures employing local ice ball

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about −15° C. to about −30° C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.

HANDPIECE ASSEMBLY FOR AN APPARATUS USED IN COSMETIC TREATMENT

A handpiece assembly 100 for an apparatus used in non-invasive cosmetic treatment, in particular, in an apparatus for non-invasive fat reduction by means of cold-induced lipolysis of fat cell, known as cryolipolysis, is provided. Said handpiece assembly 100 comprises a handle 10, provided with a control terminal 14 equipped with a user interface, said handle 10 being connectable to the treatment unit of the apparatus for cosmetic treatment by a number of fluidic and/or communication lines; a treatment head 50 configured as a cup-shaped body applicator 20 disposed between at least two cooling units 30, and an adapter 40 configured to connect the handle 10 and the treatment head 50, wherein the connection between the handle 10 and the treatment head 50 mediated by the adapter 40 is releasable.

Devices for Therapeutic Nasal Neuromodulation and Associated Methods and Systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Cryotherapy device and method for the treatment of cervical precancerous lesions

A device for providing a cryotherapy ablation treatment includes a piping assembly and a snow horn adapted to create a spray of snow from a pressurized source of a low-temperature liquid, a tubular applicator for collecting a mass of snow at a prescribed density that is sufficient to allow the mass to serve as the needed, low temperature, thermal reservoir for the device after the applicator's distal end has been disconnected from the snow horn end so that it can to be used during the treatment process, and an applicator tip adapted to allow it to connect to the applicator's distal end and be used to treat those specific locations which are to receive this treatment.

Thermotherapy application and control system

Apparatus for applying thermotherapy to a part of the human or animal body comprising an applicator having a flexible enclosure in which thermal energy transfer fluid can circulate, a connector for connecting the applicator to a control system, an interface layer for providing a thermally conductive interface between the flexible enclosure and a treatment site and, an electrically conductive supporting layer for supporting the interface layer and capable of being energized by an electrical signal from the control system to improve the thermal conductivity of the interface layer. The apparatus also includes a valve unit for connecting the applicator to a control system, a heat exchanger for cooling a thermal energy transfer fluid and a control system for controlling the application of thermotherapy. The apparatus permits manipulation and control of the molecules of the interface layer and a thermal energy transfer fluid to improve the thermal energy transfer efficiency between the applicator and a treatment site.

Ablation probe with peltier effect thermal control

A tissue ablation probe, system, and method are provided. The ablation probe comprises an elongated member, an ablative element mounted on the distal end of the elongated member, and at least one thermoelectric device mounted to the member in thermal communication with the ablative element. The system may include the ablation probe, thermal control circuitry for controlling the thermal effect of the thermoelectric device, and an ablation source for suppying ablation energy to the ablative element. A plurality of circumferentially distributed thermoelectric devices can be provided, so that radial tissue sectors can be selectively affected by independently controlling the thermal effect of the thermoelectric devices. In one embodiment, the thermoelectric device(s) can be used to cool a heat ablative element. In another embodiment, the thermoelectric device(s) can be used to heat an ablative element, thereby forming a heat ablative element. In still another embodiment, the thermoelectric device ...

Cryotherapy Device And Method For The Treatment Of Cervical Precancerous Lesions

A device for providing a cryotherapy ablation treatment includes a piping assembly and a snow horn adapted to create a spray of snow from a pressurized source of a low-temperature liquid, a tubular applicator for collecting a mass of snow at a prescribed density that is sufficient to allow the mass to serve as the needed, low temperature, thermal reservoir for the device after the applicator's distal end has been disconnected from the snow horn end so that it can to be used during the treatment process, and an applicator tip adapted to allow it to connect to the applicator's distal end and be used to treat those specific locations which are to receive this treatment.

CONTROL METHOD FOR A ONE BALLOON FITS ALL IN AUTOMATED MODE

Devices, systems, and methods for maintaining cryoballoon size, cryoballoon pressure, and/or coolant flow rate based on physical characteristics of the tissue to be ablated. In one embodiment, a cryoablation system comprises: a cryoablation device, the cryoablation device including: an expandable treatment element defining an interior chamber; and a pressure sensing system at least partially within the interior chamber; a fluid flow path including at least one valve that is in communication with at least one PID device; and a control unit including processing circuitry in communication with the pressure sensing system and the at least one PID device, the processing circuitry being configured to: determine a target pressure of the expandable treatment element based on a target size of the expandable treatment element; and determine a target flow rate of coolant through the fluid flow path based on the target pressure of the expandable treatment element.

Light source unit and projector having such a light source unit

The invention relates to a light source unit (10), comprising at least one cooling device (30); at least one luminescent substance (28); at least one excitation radiation source having a laser source (14); and at least one optical element (26), which is arranged between the at least one excitation radiation source and the at least one luminescent substance (28); wherein the at least one cooling device (30) represents a heat sink, wherein the at least one luminescent substance (28) is thermally connected to the at least one heat sink; and wherein the optical element (26) is designed as an integrated optical element and is coupled between the at least one excitation radiation source and the at least one luminescent substance (28) in such a way that at least a part of the radiation that is emitted by the at least one excitation radiation source and that is incident in an acceptance angle range of the integrating optical element (26) is subjected to at least one internal reflection in the integrating optical element (26) before said part of the radiation exits the integrating optical element (26) and hits the at least one luminescent substance (28) and that at least a part of the radiation emitted by the at least one luminescent substance (28) enters the integrating optical element (26) and exits the integrating optical element (26) as useful radiation. The invention further relates to a projector having such a light source unit (10) and to a device for fiber coupling, in particular an endoscope, having such a light source unit (10).

Cyrocatheter with coolant fluid cooled thermoelectric module

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Blood clot retrieval systems and methods

Systems and methods can be used to retrieve and remove blood clots from blood vessels. For example, this document describes catheter-based cryogenic devices that are used to retrieve and remove blood clots. The systems and methods provided herein can be used to remove blood clots from all types of blood vessels including, but not limited to, peripheral vessels, coronary arteries, central veins, pulmonary arteries, cerebral arteries, and any other type of blood vessel that can contain blood clots.

Devices for dermatological treatment

Handpiece unit for a device used in cosmetic treatment

Method of safely using controlled cooling systems and devices

Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.

Apparatus and methods for procedures related to the electrophysiology of the heart

Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Blood clot retrieval systems and methods

Method of safely using controlled cooling systems and devices

Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.

治療的鼻神経調節のためのデバイスならびに関連する方法及びシステム

【課題】治療的鼻神経調節のためのデバイスならびに関連するシステム及び方法が、本明細書に開示される。【解決手段】本技術の実施形態に従って構成される鼻領域における治療的神経調節のためのシステムは、例えば、シャフトと、シャフトの遠位部分における治療用要素とを含み得る。シャフトは、遠位部分を、患者の蝶口蓋孔の下方の標的部位に腔内に配置し得る。治療用要素は、鼻炎または他の兆候の治療のために、ヒト患者の口蓋骨のミクロ孔において節後副交感神経を治療的に調節するように構成されたエネルギー送達要素を含み得る。他の実施形態では、治療用要素は、慢性副鼻腔炎の治療のために、前頭洞、篩骨洞、蝶形骨洞、及び上顎洞を神経支配する神経を治療的に調節するように構成され得る。【選択図】図１Ａ

治療的鼻神経調節のためのデバイスならびに関連する方法及びシステム

Ocular region heat transfer devices and associated systems and methods

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

Method of safely using controlled cooling systems and devices

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

制御された冷却システムおよびデバイスを安全に使用する方法

Ablation probes including flexible circuits

A probe for performing an ablation treatment includes a shell defining an outer surface and a cryogen supply conduit positioned within the shell. The probe also includes a flexible circuit positioned on at least a portion of the outer surface of the shell. The flexible circuit might include at least one radio frequency (RF) emitter for delivering RF energy to a target tissue.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Directional cryoablation system

A cryoablation system is provided that can assume a directional activated state and includes a cryoablation probe and a controller. The cryoablation probe has an active region that includes a cooling compartment and an opposing heating compartment that are thermally insulated from one another to minimize energy losses therebetween such that ice is selectively and directionally formed at the target site. The cooling compartment can include a temperature sensor and an exhaust tube to guide a fluid or gas that exhibits a Joule Thomson cooling effect through the probe. The heating compartment can include a temperature sensor and a heater cartridge having a heater zone. The controller of the cryoablation system can process temperature measurement data from the sensors of the heating and cooling compartments and regulate the heater zone based on the temperature measurement data processing to maintain a temperature that is sufficiently constant to mitigate or prevent formation of ice on the heating compartment.

Method of safely using controlled cooling systems and devices

Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

制御された冷却システムおよびデバイスを安全に使用する方法

【課題】安全機能を有する冷却デバイスと、標的表面の安全な冷却のために冷却デバイスの温度を制御するための方法を提供する。 【解決手段】手持ち型の冷却デバイスが、（ａ）冷却媒体と、（ｂ）接触要素と、（ｃ）入力要素と、（ｄ）冷却媒体を冷却するように構成された制御モジュールとを有し、スタンバイ温度Ｃ２に達するまで冷却媒体を冷却する段階と、冷却媒体が前記スタンバイ温度に達した後に、冷却媒体の温度をスタンバイ温度に維持する段階と、冷却媒体の温度がスタンバイ温度に維持されている間に、接触要素の接触が検出されたこと、入力要素の作動が検出されたこと、または、両方に応じて、標的温度Ｃ３まで冷却媒体を冷却する段階とを備え、スタンバイ温度は、標的温度よりも高い、又は、前記標的温度に等しい。 【選択図】図１４

Control method for a one balloon fits all in automated mode

Devices, systems, and methods for maintaining cryoballoon size, cryoballoon pressure, and/or coolant flow rate based on physical characteristics of the tissue to be ablated. In one embodiment, a cryoablation system comprises: a cryoablation device, the cryoablation device including: an expandable treatment element defining an interior chamber; and a pressure sensing system at least partially within the interior chamber; a fluid flow path including at least one valve that is in communication with at least one PID device; and a control unit including processing circuitry in communication with the pressure sensing system and the at least one PID device, the processing circuitry being configured to: determine a target pressure of the expandable treatment element based on a target size of the expandable treatment element; and determine a target flow rate of coolant through the fluid flow path based on the target pressure of the expandable treatment element.

Control method for a one balloon fits all in automated mode

Ocular region heat transfer devices and associated systems

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

Devices for therapeutic nasal neuromodulation

Ocular region heat transfer devices and associated systems and methods

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

Ocular region heat transfer devices and associated systems and methods

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

安全使用受控冷却系统和设备的方法

本公开提供了一种具有安全特征的冷却设备和用于控制冷却设备的温度以安全冷却目标表面的方法。

用于治疗性鼻神经调节的装置及相关的方法和系统

本文公开了用于治疗性鼻神经调节的装置及相关的系统和方法。根据本技术的实施方案配置的用于鼻部区域中的治疗性神经调节的系统可包括例如轴和位于轴的远侧部分处的治疗元件。所述轴可将远侧部分向腔内定位在患者的蝶腭孔下方的靶位点处。所述治疗元件可包括能量递送元件，该能量递送元件配置为治疗性调节位于人类患者腭骨微孔处的神经节后副交感神经，用于治疗鼻炎或其他适应症。在其它实施方案中，所述治疗元件可配置为治疗性调节支配额窦、筛窦、蝶窦及上颌窦的神经，用于治疗慢性鼻窦炎。