12-07-2018 дата публикации
Номер: US20180193188A1
The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range. 1. A method of reshaping curvature of a region of a cornea having an initial curvature , the method comprising:inducing partial ionization in a region of the cornea by applying laser light energy below optical breakdown, wherein a majority of the laser light is in wavelengths, or integral fractions thereof, that are not absorbed directly by amino acids in collagen of the cornea.2. The method of claim 1 , further comprising:projecting an illumination pattern on the cornea;recording a pattern of reflection from the cornea with a camera; andconverting the pattern of reflection into a topography of the cornea.3. The method of claim 1 , wherein the laser light energy is applied in an illumination pattern generated by a continuous wave laser.4. The method of claim 1 , wherein the initial curvature is reshaped to a curvature corresponding to a desired topography.5. The method of claim 1 , wherein the region of the cornea to be modified is based at least in part on a deformation map.6. The method of claim 1 , wherein the inducing partial ionization comprises scanning a laser over the region of the cornea to be modified.7. The method of claim 6 , wherein the scanning comprises scanning a femtosecond laser.8. The method of claim 6 , wherein the scanning comprises scanning a femtosecond laser having an average power output from about 10 mW to about 100 mW.9. The method of claim 6 , wherein the scanning comprises scanning a femtosecond laser having ...
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