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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 30858. Отображено 100.
28-12-2018 дата публикации

Устройство для исследования отражающей способности кожного покрова

Номер: RU0000186082U1

Диагностирующее устройство, включающее источник измерительного сигнала, приемник измерительного сигнала и средство для визуального отображения уровня функционального состояния организма, при этом в качестве источника измерительного сигнала использован источник света, а приемник измерительного сигнала выполнен как фотоприемник, размещенные в корпусе устройства, отличается тем, что в качестве фотоприемника использован полупроводниковый фотоэлектронный умножитель, один выход которого через операционный усилитель связан с первым выводом аналого-цифрового преобразователя, а второй выход полупроводникового фотоэлектронного умножителя связан со вторым выводом аналого-цифрового преобразователя, при этом первый и второй выходы аналого-цифрового преобразователя связаны с входами источника света, а его третий выход связан со схемой индикации, кроме того, третий и четвертый входы аналого-цифрового преобразователя подключены через кнопочный выключатель к выводам источника питания, кроме того, оптический выход источника света и оптический вход полупроводникового фотоэлектронного умножителя размещены в полости ниши, выполненной на стороне корпуса устройства, прикладываемой к коже пациента, при этом кромка ниши по всему периметру снабжена выступающей юбкой из упругого материала, выполненной с возможностью изолирования полости ниши от внешней среды. Кроме того, в качестве схемы индикации использован световой индикатор. Кроме того, в качестве источника света использованы светодиоды с излучением в спектре видимого диапазона, с длиной волны в диапазоне от 450 до ≥630 нм. Устройство обеспечивает возможность дифференцированной оценки уровня функционального состояния организма человека и является компактным. 1 з.п. ф-лы, 2 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 186 082 U1 (51) МПК A61B 5/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61B 5/0075 (2006.01); A61B 5/44 (2006.01) (21)(22) Заявка: 2018122925, 22.06.2018 ( ...

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12-08-2021 дата публикации

Устройство визуализации поверхностных вен

Номер: RU0000205830U1

Настоящая полезная модель относится к медицинской технике и медицинскому оборудованию, а именно к неинвазивному портативному устройству для визуализации подкожных вен с использованием источников света в видимом световом диапазоне. Предлагаемое устройство может быть использовано для неинвазивной визуализации периферийных подкожных вен при проведении таких венозных манипуляций, как: введение внутривенных инъекций, забор крови из вены, установка внутривенных катетеров, проведение склеротерапии.Сущность полезной модели заключается в том, что визуализатор вен состоящий из корпуса в форме рукояти для хвата, двух элементов крепления печатной платы управления, проводного соединения, аккумуляторной батареи, коммутационного элемента, оптической линзы и крышки, имеет в своем составе печатную плату со светодиодами и токоограничивающими резисторами, изготовленную из алюминия. Использование алюминия позволяет предотвратить повышение температуры рабочей поверхности устройства свыше 46°С за счет отведения тепла от светодиодов, а также позволяет предотвратить перегрев светодиодов. Корпус имеет рабочую область подсветки в форме разомкнутого овала с прорезью 10-16 мм для проведения внутривенных инъекций, установки катетеров или забора крови. Светодиоды находятся в параллельном включении, каждый светодиод последовательно соединен с токоограничивающим резистором, что позволяет сформировать пороговое напряжение для каждого светодиода, которое не будет зависеть от пороговых напряжений других светодиодов в цепи, а также позволяет ограничить рабочий ток каждого светодиода. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 205 830 U1 (51) МПК A61B 5/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61B 5/0059 (2021.05); A61B 5/0077 (2021.05); A61B 5/489 (2021.05) (21)(22) Заявка: 2021110499, 15.04.2021 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Общество с ограниченной ответственностью "МЭЙДЖИК ВЬЮ" (RU) ...

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03-02-2022 дата публикации

Устройство для визуализации вен в инфракрасном диапазоне

Номер: RU0000209146U1

Настоящая полезная модель относится к медицинской технике и медицинскому оборудованию, а именно к неинвазивному портативному устройству для визуализации подкожных вен с использованием источников света в инфракрасном (ИК) диапазоне и ИК-камеры. Предлагаемое устройство может быть использовано для неинвазивной визуализации периферийных подкожных вен при проведении таких венозных манипуляций, как: введение внутривенных инъекций, забор крови из вены, установка внутривенных катетеров, проведение склеротерапии, проведение диагностики и исследования сосудов и сосудистых нарушений. За счет использования длин волн ближнего ИК-диапазона происходит контрастная визуализация вен, так как свет с длиной волны более 700 нм проникает глубже в кожу. При этом ближний ИК-свет минимально поглощается меланином (высокомолекулярный пигмент кожи), но сильно поглощается кровью в венах. Это позволяет дифференцировать кровеносные сосуды и окружающие ткани. В частности, ближний ИК-свет, попадающий на участок тела человека, поглощается кровеносными сосудами. Чем больше ближний ИК-свет поглощается, тем меньше происходит его отражение, которое фиксирует ИК-камера. Чем меньше поглощают ближний ИК-свет окружающие ткани, тем больше они его отражают. Поэтому, изображение вен, полученное ИК-камерой, имеет темную контрастную структуру, а окружающие ткани имеют более светлый оттенок. Сущность полезной модели заключается в том, что устройство для визуализации вен в инфракрасном диапазоне, состоящее из принимающего устройства, корпуса, инфракрасной камеры с инфракрасными светодиодами и датчиком освещенности, соединенных между собой первой печатной платой, микроконтроллера, контроллера аккумуляторной батареи и драйвера инфракрасных светодиодов, соединенных между собой второй печатной платой, кнопки включения и аккумуляторной батареей, соединенных со второй печатной платой проводным соединением, передает изображение вен по беспроводному соединению Wi-Fi принимающему устройству (планшету, монитору, ...

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12-01-2012 дата публикации

Systems, Methods and Computer-Accessible Medium Which Provide Microscopic Images of at Least One Anatomical Structure at a Particular Resolution

Номер: US20120008146A1
Принадлежит: General Hospital Corp

Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

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26-01-2012 дата публикации

Methods and apparatus for assesment and treatment of body cavities

Номер: US20120022380A1
Автор: Ary S. Chernomorsky
Принадлежит: Transmed7 LLC

Methods and apparatus for detection, assessment and optionally treatment of the cancerous tissue in the natural and manmade body cavities. An expandable cavity assessment device that is coupled with cancer detecting elements is placed in a cavity in close proximity to the site of cancerous tissue. The cavity assessment device may receive an optical fiber, or other type of energy conduit and potentially a radioactive source for interstitial radiation therapy. The cavity assessment device may be equipped with a balloon member coupled with electro conductive elements. Further, a system facilitating substance communication with the internal surface of the cavity is provided.

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09-02-2012 дата публикации

Systems and methods for the measurement of surfaces

Номер: US20120035469A1

A portable, hand-held, non-contact surface measuring system comprises an image capturing element, at least four projectable reference elements positioned parallel to one another at known locations around the image capturing element, a processing unit, and a user interface. The invention further discloses a method for the noncontact surface measurement comprising projecting at least four references onto a target surface, capturing an image of the targeted surface and the projected references with the image transferring device, transferring the image to a processing unit, processing the image using triangulation-based computer vision techniques to correct for skew and to obtain surface measurement data, transferring the data to the user interface, modifying the data with the user interface. The systems and methods for the measurement of surfaces can be applied to the measurement of biological surfaces, such as skin, wounds, lesions, and ulcers.

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09-02-2012 дата публикации

Brain information output apparatus, robot, and brain information output method

Номер: US20120035765A1

A brain information output apparatus includes an intention determination information storage unit in which two or more pieces of intention determination information can be stored, with each intention determination information including a pair of an intention identifier, and a learning feature amount group including one or more feature amounts extracted from second learning data that is obtained by converting first learning data into intracerebral brain activity data, the first leaning data being acquired from the outside of the cranium of a user when the user performs a trial according to one intention; a first brain activity data acquiring unit that acquires first brain activity data from the outside of the cranium of a user; a second brain activity data acquiring unit that converts the first brain activity data to intracerebral brain activity data, and acquires second brain activity data; a feature amount group acquiring unit that acquires, from the second brain activity data, an input feature amount group including one or more feature amounts; an intention identifier acquiring unit that acquires an intention identifier corresponding to the input feature amount group based on the two or more pieces of intention determination information; and an intention identifier output unit that outputs the intention identifier.

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16-02-2012 дата публикации

Device for evaluating condition of skin or hair

Номер: US20120041283A1
Принадлежит: Conopco Inc

A hand-held device for evaluating skin or hair condition which includes a housing, a hydration meter, and a plurality of light emitting diodes (LEDs). The hydration meter is supported within the housing and has an external surface portion contactable against skin or hair to measure moisture content. At least one of the LEDs both emits and absorbs light. Advantageously the LEDs include a red, a blue, a green and two infrared wavelength light emitters.

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23-02-2012 дата публикации

Imaging apparatus and imaging method

Номер: US20120044457A1
Принадлежит: Canon Inc

An imaging apparatus includes changing unit for changing a positional relation of irradiation positions of a plurality of measuring beams to be radiated onto an object. The imaging apparatus includes scanning unit for scanning the plurality of measuring beams in the positional relation which has been changed by the changing unit, and acquiring unit for acquiring an optical coherence tomographic image of the object on the basis of the plurality of measuring beams.

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01-03-2012 дата публикации

Image acquisition and display method and image capturing and display apparatus

Номер: US20120050514A1
Принадлежит: Fujifilm Corp

Identifying, based on a special image, a prescribed region of interest in a special image, determining a boundary line of an area which includes a region in an ordinary image corresponding to the identified region of interest and a predetermined margin added to the region, and displaying a boundary line of the region and the boundary line of the area in the ordinary image.

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01-03-2012 дата публикации

Non-Invasive Tissue Glucose-Level Monitoring

Номер: US20120053429A1
Принадлежит: Individual

A non-invasive analyte monitoring instrument has a radiation source for directing excitation radiation to a portion of a surface of a tissue wherein said source emits radiation at a plurality of different wavelengths that excites a target in said tissue causing said target to emit radiation such that the radiation received at the surface provides an analyte level indication of the patient. A radiation detector positioned to receive radiation emitted from the surface wherein said radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation. A processing circuit operatively connected to the radiation detector that translates radiation received at the surface to a measurable signal to obtain said analyte level indication, wherein said radiation source comprises a visible light source or an ultraviolet light source and wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD, a flavoprotein, and any combination thereof.

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01-03-2012 дата публикации

Information processing apparatus in oct system

Номер: US20120053904A1
Принадлежит: Canon Inc

Provided is an information processing apparatus in an OCT system capable of acquiring tomographic information and moving velocity information of an object at high speed and over a region larger than a spot size. The apparatus splits light including a plurality of lights of at least first and second light into measurement lights and reference lights and acquires tomographic information and moving velocity information of an object, having: a scanning optical system for scanning with the measurement light; an optical system for applying the measurement light to different spot positions; interference signal generating devices which generate first and second interference signals from a return light obtained when the measurement light is applied to the positions and the reference light reflected by a reference mirror; and a signal processing device which calculates a variation in phase using the interference signals and computes a moving velocity of the object.

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08-03-2012 дата публикации

Re-calibration of pre-recorded images during interventions using a needle device

Номер: US20120059251A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.

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15-03-2012 дата публикации

Imaging device and imaging method

Номер: US20120062901A1
Принадлежит: Canon Inc

The present invention relates to a structure in which a sensor includes a first area and a second area upon which dispersed first and second lights are focused. The first and second areas are disposed in a dispersion direction or a direction perpendicular to the dispersion direction. A distance between the first and second areas is adjusted by using a distance between a plurality of fiber ends from which a plurality of combined lights exit and an optical magnification at a detecting section.

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29-03-2012 дата публикации

Systems and methods for analysis and treatment of a body lumen

Номер: US20120078121A1
Принадлежит: Cornova Inc

A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.

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05-04-2012 дата публикации

Method for analyzing biological specimens by spectral imaging

Номер: US20120082362A1
Принадлежит: Northeastern University Boston

A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.

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05-04-2012 дата публикации

System and method for raman chemical analysis of lung cancer with digital staining

Номер: US20120083678A1
Автор: Amy Drauch, John Maier
Принадлежит: ChemImage Corp

The present disclosure provides for a system and method for diagnosing biological samples that combines the visual staining features familiar to pathologists with the accurate, reliable, and nondestructive capabilities of Raman chemical imaging. The invention disclosed herein may be applied to diagnose lung cancer samples. A method may comprise illuminating a biological sample to generate interacted photons, filtering said interacted photons using a tunable filter, and detecting interacted photons to generate a test Raman data set representative of said sample. The method may further comprise applying at least one chemometric technique and/or a digital stain to said test Raman data set. This test Raman data set may be analyzed to diagnose said sample as comprising at least one of: adenocarcinoma, mesothelioma, and combinations thereof. A system may comprise an illumination source, a tunable filter, and a detector configured to generate a test Raman data set representative of a biological sample.

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12-04-2012 дата публикации

Camera for detecting driver's state

Номер: US20120087541A1
Автор: Nakamura Hiroshi

The present invention provides a camera for detecting a driver's drowsiness state, which can increase the number of pixels in an image of a driver's eye even when using an image sensor having the same number of pixels as a conventional camera instead of a high definition camera. The camera of the present invention is, thus, capable of determining whether the driver's eyes are open or closed. The camera for detecting the driver's state according to the present invention includes a cylindrical lens mounted in front of the camera configured so as to enlarge an image in the vertical direction, a convex lens located in the rear of the cylindrical lens, an image sensor for taking an image of a driver's face formed by the cylindrical lens and the convex lens, and an image processor for extracting an eye area from the image of the driver's face and determining whether the driver's eyes are open or closed.

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31-05-2012 дата публикации

Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract

Номер: US20120136209A1

Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities.

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07-06-2012 дата публикации

Patient monitoring system

Номер: US20120138801A1
Автор: Irvin J. Vanderpohl
Принадлежит: Individual

A patient support apparatus includes a monitoring system having a first detector and a controller. The first detector detects electromagnetic radiation from a first field of view of the first detector and providing a signal indicative of characteristics of the electromagnetic radiation. The controller includes a processor coupled to the first detector and a memory device including instructions that, when executed by the processor, cause the processor to processes the signal from the first detector, translate the signal into an array of data, and evaluate the data in the array to determine characteristics of a patient positioned in the first field of view.

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26-07-2012 дата публикации

Common detector for combined raman spectroscopy-optical coherence tomography

Номер: US20120188538A1
Принадлежит: VANDERBILT UNIVERSITY

In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.

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26-07-2012 дата публикации

Imaging apparatus for diagnosis and control method thereof

Номер: US20120190974A1
Автор: Satoru Suehara
Принадлежит: Terumo Corp

An imaging apparatus for diagnosis is connected with a probe including a transmitting and receiving unit transmitting a light transmitted from a light source continuously to the inside of a body cavity and concurrently, receiving a reflected light continuously from the inside of the body cavity, and generates a tomographic image inside the body cavity based on the obtained reflected light by obtaining the reflected light from the transmitting and receiving unit while rotating the transmitting and receiving unit. The apparatus comprises: a mechanism for extracting intensity of the reflected light obtained by a phenomenon that the light transmitted to the transmitting and receiving unit is reflected at the transmitting and receiving unit; and a mechanism for judging whether or not the extracted intensity of each reflected light at each rotary angle of the transmitting and receiving unit lies in a range of a predetermined variation width.

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09-08-2012 дата публикации

Intrinsic and swept-source raman spectroscopy

Номер: US20120203114A1
Принадлежит: Individual

The present invention pertains to a method and an apparatus for Raman spectroscopy of human tissue. Human tissue is illuminated with a laser emitting a first wavelength of light. A Raman signal is measured and optical properties are determined at this wavelength such that the measured Raman signal can be corrected based on determined optical properties. Determined optical properties may be the scattering coefficient and absorption coefficient of the tissue. A system for Raman spectroscopy of human tissue includes a frequency sweeping laser light source for illumination, and a filtered detector for collecting the Raman signal.

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30-08-2012 дата публикации

Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes

Номер: US20120220870A1
Принадлежит: Leland Stanford Junior University

Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.

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06-09-2012 дата публикации

Meibomian gland imaging

Номер: US20120226156A1
Принадлежит: TearScience Inc

A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

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13-09-2012 дата публикации

Bodily fluid composition analyzer with disposable cassette

Номер: US20120232362A1
Принадлежит: Optiscan Biomedical Corp

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

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13-09-2012 дата публикации

Method and Apparatus for Cervical Cancer Screening

Номер: US20120232408A1
Принадлежит: Individual

The present invention relates to an apparatus for cervical cancer screening, comprising one or more light sources aligned with a beginning of a first optical test path and a beginning of a second optical test path, one or more optical detectors aligned with an end of the first optical test path and an end of the second optical test path, and a processor coupled to the one or more light sources and the one or more optical detectors and methods for using the same. The present invention further relates to a method for cervical cancer screening.

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27-09-2012 дата публикации

Health monitoring appliance

Номер: US20120245464A1
Автор: Bao Tran
Принадлежит: Individual

A heart monitoring system for a person includes one or more wireless nodes; and a wearable appliance in communication with the one or more wireless nodes, the appliance monitoring vital signs. Other implementations can monitor heart rate, heart rate variability, respiratory rate, fluid status, posture and activity.

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04-10-2012 дата публикации

Control apparatus, imaging control method, and storage medium

Номер: US20120249769A1
Принадлежит: Canon Inc

A control apparatus of an imaging apparatus, includes a selection unit configured to select an image-capturing site of a subject to be examined, a control unit configured to control adjustment of a member of the imaging apparatus, according to the selected image-capturing site, and a determination unit configured to determine whether to perform the adjustment or not in response to a change of image-capturing sites through the selection by the selection unit, based on image-capturing conditions for the image-capturing sites before and after the change of the image-capturing sites.

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04-10-2012 дата публикации

Image recording device for the simultaneous recording of magnetic resonance image data and nuclear medical image data

Номер: US20120253174A1
Автор: Stefan Popescu
Принадлежит: SIEMENS AG

An image recording device is disclosed for the simultaneous recording of magnetic resonance image data and nuclear medical image data, in particular PET image data. In at least one embodiment, the image recording device includes a nuclear medical detector arrangement integrated into a magnetic resonance device, wherein a fluorescence detector arrangement including an optical system and designed for fluorescence imaging is also integrated into the magnetic resonance device.

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04-10-2012 дата публикации

Method of viewing a surface

Номер: US20120253203A1
Принадлежит: Gillette Co LLC

A method of viewing a surface comprising taking at least a first image from a first position and a second image from a second position to allow for comparative analysis and diagnosis of the surface.

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25-10-2012 дата публикации

Method of discriminating longitudinal melanonychia and visualizing malignancy thereof

Номер: US20120268462A1
Принадлежит: Mitaka Kohki Co Ltd

In a digital color image of longitudinal melanonychia, RGB parameter values of each pixel are assumed as three components to form a three-dimensional vector. Latitudinal and longitudinal variables are obtained for each three-dimensional vector in an RGB space. The latitudinal and longitudinal variables are used to define a distribution of points, and from the distribution, a discrimination index is found. The discrimination index is classified according to a threshold, to discriminate whether the longitudinal melanonychia is malignant or benign. The distribution of points is displayed to realize visualization of the malignancy of the longitudinal melanonychia.

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25-10-2012 дата публикации

Catheter

Номер: US20120271174A1
Автор: Shigenobu Iwahashi
Принадлежит: Terumo Corp

A catheter includes a catheter main body provided with a window portion through which an inspection wave passes, a drive shaft provided with a detection unit detecting the inspection wave and concurrently installed advanceably and retractably in an axial direction inside the catheter main body, and a bias member biasing a force onto the drive shaft for moving the drive shaft forward toward the distal side thereof.

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08-11-2012 дата публикации

Systems and methods for endoscopic angle-resolved low coherence interferometry

Номер: US20120281224A1
Автор: Adam Wax, John W. Pyhtila
Принадлежит: Duke University

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

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08-11-2012 дата публикации

Method and apparatus to detect coronary artery calcification or disease

Номер: US20120283530A1
Принадлежит: Individual

Coronary artery calcification (CAC) occurs at an earlier age in diabetes and is a risk factor for coronary artery disease (CAD) in subjects with or without diabetes. One postulated mechanism for the increased CAC is the accelerated accumulation of advanced glycation end products (AGEs) in the vasculature. As certain collagen AGEs fluoresce, skin intrinsic fluorescence (SIF) can act as a novel maker of collagen AGEs levels. The present invention provides methods and apparatuses for detecting SIF that can be a useful marker of CAD risk and a therapeutic target.

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15-11-2012 дата публикации

Tissue imaging system and in vivo monitoring method

Номер: US20120289801A1
Автор: Hiroshi Yamaguchi
Принадлежит: Fujifilm Corp

An in vivo monitoring method in a laparoscope system is provided. An object image is sequentially created with expression of a surface color of an object in a body cavity. A lock area (specific area) is determined within the object image, the lock area being movable by following motion of the object. A monitor image including a graph of oxygen saturation is generated according to a part image included in the object image and located in the lock area. The monitor image is displayed. Preferably, the oxygen saturation of the lock area is acquired according to two spectral data with respect to wavelengths of which an absorption coefficient is different between oxidized hemoglobin and reduced hemoglobin in data of the object image. The object is constituted by a blood vessel.

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29-11-2012 дата публикации

System and method for specificity-based multimodality three- dimensional optical tomography imaging

Номер: US20120302880A1
Принадлежит: Shenyang Institute of Automation of CAS

A system and method for specificity-based multimodality three-dimensional optical tomography imaging comprises steps of: optical imaging to obtain a light intensity of body surface optical signal of an imaging target; CT imaging to obtain structure volume data; establishing an equation representing a linear relationship between the distribution of the obtained light intensity of body surface optical signal of the imaging target, the obtained CT discrete mesh data and the distribution of unknown internal self-luminescence light sources; establishing a dynamic sparse regularization target function in every iteration for the equation; and reconstructing a tomography image. The present invention well considers the optical specificity of tissue, in which there is a non-uniform optical characteristic parameter distribution within the same tissue when finite element modeling is used, which is closer to the real situation, so that an accurate imaging effect is achieved.

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27-12-2012 дата публикации

System for Non-Invasive Assay of Liver Function

Номер: US20120330116A1
Принадлежит: Cardiox Corp

A system, method and apparatus are disclosed for using a transcutaneous detection system to measure the quantity of a circulating organ activity detection analyte in the blood, and thereby assay the activity of an organ. A preferred organ for assay is the human liver and a preferred indicator is indocyanine green (ICG) dye The procedure is under the control of a monitor/controller having a visual display and capable of providing cues to the operator. A sensor array apparatus for use in conjunction with the system monitor/controller is configured for increased sensitivity of assaying organ function.

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03-01-2013 дата публикации

Hand-Held Raman Laser Device for Distant Life-Death Determination by Molecular Peri-Mortem Plume Fuzzy Membership Function

Номер: US20130006062A1
Принадлежит: US Department of Army

Multiple functional systems are integrated to configure a portable handheld decision-aid device for first responder medics. Fuzzy membership functions of “life” and “death” are used to determine the status of fallen people using remote measurements. EO/IR cameras can be used to detect and identify casualties in a mass injury situation, while also estimating body temperature. Using the temperature, along with the remote estimation of a second vital sign, the life membership proportion can be estimated from the ground truth by using a 2D projection of stable vital signs. The other fuzzy membership function, death, can be estimated by the presence or absence of peri-mortem and post-mortem molecules. These molecules are only released after death and provide a certain indication of death. Solid state UV laser resonance Raman backscattering from these molecules allows the device to analyze the molecules present in a plume around the casualty.

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03-01-2013 дата публикации

System and method for sub-surface fluorescence imaging

Номер: US20130006116A1
Принадлежит: UNIVERSITY HEALTH NETWORK

Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

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10-01-2013 дата публикации

Personal emergency response (per) system

Номер: US20130009783A1
Автор: Bao Tran
Принадлежит: Individual

Systems and methods for identifying an activity of an object includes identifying each elemental motion of a sequence of elemental motions of a device attached to the object; and identifying the activity of the object, comprising matching the sequence of identified elemental motions of the device with a library of stored sequences of elemental motions, wherein each stored sequence of elemental motions corresponds with an activity.

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31-01-2013 дата публикации

Mechanism Of Quantitative Dual-Spectrum IR Imaging System For Breast Cancer

Номер: US20130030304A1
Принадлежит: National Taiwan University NTU

A mechanism of quantitative dual-spectrum IR imaging (QDS-IR) system for examining the breast cancer is reported. The major mechanism of the system is a pair of long-wave Infra-red (LIR) and middle-wave Infra-red (MIR) cameras with the keen temperature sensitivity and the high spatial resolution. The optical axes of cameras are calibrated by the help of two calibration makers set up on the seat for carrying an object to make them parallel to each other and locate on the same level. The design provides an imaging system with the high reproducibility supported by 7 free degrees and the high adjustability. The proposed system could ensure the positions of the object and two cameras are the same at the different time points and find the best relative positions between the seat and two cameras for the objects with different body types. Therefore, it has potential ability to detect breast cancer or monitor the effect of chemotherapy.

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31-01-2013 дата публикации

Medical Device for Diagnosis Pressure Ulcers

Номер: US20130030308A1
Автор: Mark B. Friedman
Принадлежит: AugmenTech Inc

Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the patient and collects the optical reflectance data. The controller processes the data to determine whether there exists a pressure ulcer and, if there is one, its depth. The tip may also include a pressure sensor for sensing the pressure at which the tip is applied to the patient's skin.

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28-02-2013 дата публикации

Detection of lipid core plaque cap thickness

Номер: US20130053698A1
Принадлежит: Infraredx Inc

Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed.

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14-03-2013 дата публикации

SENSING MOISTURE LEVEL OF HUMAN SKIN

Номер: US20130066170A1
Принадлежит:

A human skin moisture measuring device having an interdigitated resistive sensor formed on a plate-like transparent support is described, with a face designed to be placed into contact with the skin to be subjected to the moisture degree measurement. The device further comprises image sensing means turned towards the opposite face of the support and a lighting device arranged sideways relative to the support to direct the light radiation in the support at a prefixed angle. Means for processing the signal coming from the interdigitated resistive sensor and from the image sensing means give as output a value of the measured moisture degree that is normalized with respect to the actual surface of contact between skin and sensor. 1. A human skin moisture measuring device comprisingan interdigitated resistive sensor wherein said sensor is formed on a plate-like transparent support with a face to be placed into contact with skin a moisture degree of which has to be measured,image sensing means turned towards an opposite face of said support,a lighting device arranged sideways relative to said support to direct light radiation within said support at a prefixed angle, andmeans for processing a signal from said interdigitated resistive sensor,wherein said image sensing means give as output a value of measured moisture degree that is normalized with respect to a contact surface between skin and sensor.2. The device according to claim 1 , whereinsaid plate-like transparent support is a flat plate defined by a side flank or thickness andsaid lighting device is arranged substantially coplanar relative to said flat plate, whereby the plate is irradiated through its thickness.3. The device according to claim 2 , wherein an incidence angle (θ) of the light radiation emitted by said lighting device is comprised between 45° and 80°.4. The device according to claim 1 , wherein said lighting device is formed by one or more lighting sources of LED type or equivalent.5. The device ...

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21-03-2013 дата публикации

Confirming that an image includes at least a portion of a target region of interest

Номер: US20130070980A1
Принадлежит: SEARETE LLC

Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit that receives a first medical image. The first medical image includes a selected target region of interest of an individual patient's body part, and a landmark subsurface feature of the individual patient's body part having a first spatial relationship with the selected target region. The receiver circuit receives a second medical image that includes a candidate region of interest of the individual patient's body part, and a landmark feature of the individual's patient body part having a second spatial relationship with the candidate region. A feature matching circuit determines a correspondence between the candidate landmark subsurface feature and the associated landmark subsurface feature. A reporting circuit generates informational data indicating the second medical image includes at least a portion of the selected target region of interest. A communication circuit outputs the informational data.

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21-03-2013 дата публикации

APPARATUS FOR THE NON-INVASIVE MEASUREMENT OF TISSUE FUNCTION AND METABOLISM BY DETERMINATION OF STEADY-STATE FLUORESCENCE ANISOTROPY

Номер: US20130072769A1
Автор: ZUCKERMAN RALPH
Принадлежит:

A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control. 1. A signal processing apparatus for non-invasively evaluating human tissue in a clinical setting , the apparatus comprising:a stimulator configured to stimulate a resting tissue to change its metabolism and become a stimulated tissue, the stimulator comprising a light source configured to irradiate the tissue using steady-state light with wavelengths of 400 to 700 nm;a light source configured to irradiate the resting and stimulated tissue with polarized light so as to cause an endogenous fluorophor in the tissue to fluoresce;a determination module configured to determine a resting steady-state fluorescence anisotropy of emitted fluorescence in the resting tissue and a stimulated steady-state fluorescence anisotropy of emitted fluorescence in the stimulated tissue; and construct a resting fluorescence anisotropy map based on the resting steady-state fluorescence anisotropy and a stimulated fluorescence anisotropy map based on the stimulated steady-state fluorescence anisotropy;', 'determine a functional capacity of the tissue by subtracting the resting fluorescence anisotropy map from the stimulated fluorescence anisotropy map; and', 'compare the functional capacity of the tissue to a functional capacity of a control tissue similarly evaluated to identify a tissue dysfunction., 'a computing module configured to2. The apparatus of claim 1 , wherein the stimulator is configured to administer supplemental ...

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04-04-2013 дата публикации

SURGICAL LIGHTING SOURCES FOR USE WITH FLUOPHORE-TAGGED MONOCLONAL ANTIBODIES OR FLUOROPHORE-TAGGED TUMOR AVID COMPOUNDS

Номер: US20130085385A1
Автор: Luiken George A.
Принадлежит:

The present invention describes light source devices to provide white and blue (401-510 nm) light for the in vivo identification of diseased tissue using fluorescence based tissue targeting. The light source devices are configured with a variety of LED lights capable of emitting white and blue light with at least one excitation wavelength in the range from about 401 nm to about 500 nm (for example, 470 nm to 495 nm) to irradiate an in vivo body part of a subject containing tumor or diseased tissue. The tumor or diseased tissue has fluorophore-tagged targeting constructs attached. The fluorophores used in the targeting constructs have emission spectra greater than 515 nm. The fluorescence emanating from the fluorescent targeting construct in response to the excitation wavelength is directly viewed with long-pass filtered (515 nm) lenses and is used to determine the location and/or surface area of the diseased tissue in the subject. Fluorescence based surgical identification provides more accurate disease resection. 1. A method for in vivo diagnosis of diseased tissue in a subject in need thereof , the method comprising:a) providing a light source device comprising one or more light sources configured to provide at least one excitation wavelength in the range from about 401 nm to about 510 nm or from about 470 nm to about 495 nm;b) irradiating an in vivo body part of the subject containing diseased tissue with the light source and directly viewing fluorescence emitted in response to the light source, the fluorescence being emitted from a fluorescent targeting construct administered to the subject and which is specifically bound to or taken up by the diseased tissue in the body part; andc) determining a location or a surface area of the diseased tissue in the subject from the fluorescence provided by the targeting construct.2. The method of claim 1 , wherein the light is substantially lacking in wavelengths greater than about 500 nm or 510 nm.3. The method of claim 1 , ...

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11-04-2013 дата публикации

Digital Holographic Method of Measuring Cellular Activity and Measuring Apparatus with Improved Stabililty

Номер: US20130088568A1
Автор: David D. Nolte
Принадлежит: PURDUE RESEARCH FOUNDATION

Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, which should not be confused with mechanical motion of the system. Apparatus for motility contrast imaging that provides increased mechanical stability is disclosed. It is based on common-path configurations, in which the signal and reference beams share optical elements in their paths to the detector. The two beams share mechanical motions in common, and hence these motions do not contribute to the signal.

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11-04-2013 дата публикации

SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL TREATMENT OF TARGET TISSUES WITHIN THE EARS USING A GUIDE BLOCK STRUCTURE

Номер: US20130090544A1
Принадлежит: ACCLARENT, INC.

Systems and methods for treating a patient having a head with a first ear and a second car, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. 18-. (canceled)9. A system for treating a patient , the patient having a head with a first ear and a second ear , the system comprising: a support structure engageable with the head of the patient so that the support structure and head define a receptacle therebetween; an material receivable by the receptacle , the injectable material having a workable state allowing adjustment to alignment between the support structure and a target tissue of the first ear , and a hardened state for stabilizing the support structure relative to the target tissue; and a device mountable to the support structure , the device actuatable so as to therapeutically remodel the target tissue of the first ear.10. The system of claim 9 , wherein the material comprises impression material.11. The system of claim 9 , wherein the target tissue comprises a tympanic membrane claim 9 , and further comprising an image capture device supported by the support structure and oriented so as to image the target tissue of the first ear so that alignment of the support system with the ear can be performed with reference to a display of the captured image.12. The system of claim 11 , wherein the support structure comprises a fluid barrier configured for retaining a fluid in the ear canal in fluid communication with the tympanic membrane claim 11 , the fluid barrier separating the material from the fluid.13. The system of claim 12 , further comprising an iontophoresis electrode ...

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11-04-2013 дата публикации

SIMULTANEOUS MULTI-MODALITY INVERSE OPTIMIZATION FOR RADIOTHERAPY TREATMENT PLANNING

Номер: US20130090549A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

When performing multimodal radiotherapy planning, an optimizer () concurrently optimizes a combined treatment plan that employs an intensity modulated radiotherapy (IMRT) device () and an intensity modulated proton therapy (IMPT) that respectively generate a photon beam and an ion beam for treating a volume of interest () in a patient (). A simulator () iteratively generates multiple variations of a simulation model () according to optimization parameters that are varied by the optimizer () until the simulation model () satisfies user-entered treatment objective criteria () (e.g., maximum dose, does placement, etc.) 1. A system that facilitates optimization of a multimodal radiation therapy plan employing both photon beam and ion beam radiation treatments , including: a display on which is presented to the user information related to one or more radiation treatment plan simulation models;', 'an optimizer that concurrently optimizes dose delivery from a photon therapy device and an ion therapy device in one or more simulation models by iteratively adjusting a plurality of optimization parameters for each of the photon therapy device and the ion therapy device during simulation; and, 'an input graphical user interface (GUI) that includesa simulator that generates the one or more simulation models according to the optimization parameters.2. The system according to claim 1 , wherein the optimizer identifies an optimal simulation model that satisfies predefined radiation treatment objective criteria.3. The system according to claim 1 , further including:a diagnostic scanner that acquires image data of a volume of interest in a patient to be treated using a combined photon and ion radiation treatment; anda reconstruction processor that reconstructs the acquired image data into one or more images that are used by the simulator to identify contours of the patient and the volume of interest to be treated.4. The system according to claim 1 , wherein the ion therapy device ...

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18-04-2013 дата публикации

OPTICAL SENSOR DEVICE AND IMAGE PROCESSING UNIT FOR MEASURING CHEMICAL CONCENTRATIONS, CHEMICAL SATURATIONS AND BIOPHYSICAL PARAMETERS

Номер: US20130094730A1
Автор: Segman Yosef
Принадлежит: CNOGA HOLDINGS LTD.

Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable. 1. An image processing device for obtaining biophysical information about a mammalian subject , said image processing device comprising:an image receiving unit for receiving a video electronic color image of a first tissue of the mammalian subject, the electronic color image comprising spatial temporal per pixel information for a color space of a first visible color, spatial temporal per pixel information for a color space of a second visible color and spatial temporal per pixel information for a color space of a third visible color, the electronic color image derived from light reflected from and/or traversing the first tissue, the light incident from a continuous or discontinuous, filtered or unfiltered, natural or artificial, light source and having a wavelength between near UV and near IR; andan image processing unit for electronically processing said image by transforming per pixel information for the first, second and third visible colors to transformed per pixel information for the ...

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18-04-2013 дата публикации

Digital Holographic Method of Measuring Cellular Activity and of Using Results to Screen Compounds

Номер: US20130096017A1
Автор: David D. Nolte, Kwan Jeong
Принадлежит: PURDUE RESEARCH FOUNDATION

Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, not to be confused with mechanical motion of the system. The use of the resulting spectrogram response signatures, or “fingerprint” data, of known compounds is disclosed to screen new compounds for leads as to those having potentially beneficial mechanisms of action. The “fingerprint” data of known toxic compounds can be used to screen new compounds for toxicity.

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18-04-2013 дата публикации

SYSTEM, METHOD AND ARTICLE FOR NORMALIZATION AND ENHANCEMENT OF TISSUE IMAGES

Номер: US20130096392A1
Автор: Adams Bruce
Принадлежит: CERNOVAL, INC.

In medical imaging, a fiducial marker facilitates tissue image correlation that allows for image analysis, normalization and correction of the optical exposure and spectral and spatial distribution in order to compensate for the surface reflections, sub surface tissue interactions and spatial orientation of the excitation and imaging axes to the subject tissue. Using a cross comparison, clinicians can model tissue image data in different forms in order to reference and compare data from various spectral components and or from different images. This may enhance human interpretation between images including the variations between images even when the spectral, spatial and optical conditions or the image resolution or sensitivity are compromised. Such may be used to assess cosmetic, moisturizing, therapeutic materials and treatments. 129.-. (canceled)30. A system for use in tissue analysis , the system comprising:at least one processor; andat least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to:compare an appearance of at least one shape of at least a first fiducial marker in a first digital image of a portion of a tissue to at least one defined actual shape of the fiducial marker;compare an appearance of each of a plurality of sections of the fiducial marker in the first digital image to respective ones of defined sections of the fiducial marker including a number of tissue phantoms each having a respective spectral characteristic that matches a respective spectral characteristic of tissue of a type represented in the first digital image; andat least one of correlate, normalize, or correct at least the first digital image, based at least in part on the comparisons.31. The system of wherein the fiducial marker includes a scatter layer that overlies at least some of the tissue phantoms and which simulates an optical character of the type of tissue represented in the first digital ...

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18-04-2013 дата публикации

METHOD AND APPARATUS FOR PERSONALIZED PHYSIOLOGIC PARAMETERS

Номер: US20130096395A1
Принадлежит: CORVENTIS, INC.

Methods and apparatus combine patient measurement data with demographic or physiological data of the patient to determine an output that can be used to diagnose and treat the patient. A customized output can be determined based the demographics of the patient, physiological data of the patient, and data of a population of patients. In another aspect, patient measurement data is used to predict an impending cardiac event, such as acute decompensated heart failure. At least one personalized value is determined for the patient, and a patient event prediction output is generated based at least in part on the personalized value and the measurement data. For example, bioimpedance data may be used to establish a baseline impedance specific to the patient, and the patient event prediction output generated based in part on the relationship of ongoing impedance measurements to the baseline impedance. Multivariate prediction models may enhance prediction accuracy. 1. An apparatus to monitor a patient , the apparatus comprising:at least two electrodes coupled to circuitry to measure an impedance of the patient;at least one processor to receive the measured impedance and patient data, the at least one processor configured to determine an output based on the impedance and the patient data.2. The apparatus of claim 1 , wherein the patient data corresponds to a demographic of the patient.3. The apparatus of claim 2 , wherein the patient demographic corresponds to one or more of a gender of the patient claim 2 , an age of the patient claim 2 , or a race of the patient.4. (canceled)5. The apparatus of claim 1 , wherein the patient data corresponds to fat of the patient comprising one or more of a percent body fat of the patient claim 1 , a body mass index claim 1 , a height of the patient claim 1 , a weight of the patient claim 1 , a caliper measure of the fat of the patient claim 1 , a tape measure test of the patient claim 1 , a near infrared interactance claim 1 , images of the ...

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18-04-2013 дата публикации

SENSITIVITY EVALUATION SYSTEM, SENSITIVITY EVALUATION METHOD, AND PROGRAM

Номер: US20130096397A1
Принадлежит: NEC Corporation

Provided is a sensitivity evaluation system for estimating sensitivity of a subject from bio-information with high accuracy, including: an acquisition unit to acquire as biological data, a reaction of a sympathetic nervous system and a reaction of a parasympathetic nervous system; a biological data analysis unit to judge from the obtained biological data, a candidate group of sensitivity factors that the subject has; a positive/negative analysis unit to judge from information obtained from the subject, whether an inner state of the subject is pleasant or unpleasant; and a comprehensive evaluation unit to integrat analysis results of the biological data analysis unit and the positive/negative analysis unit to estimate the sensitivity comprehensively. 1. A sensitivity evaluation system , comprising:an acquisition unit to acquire as biological data a reaction of a sympathetic nervous system and/or a reaction of a parasympathetic nervous system;a biological data analysis unit to judge from the obtained biological data, a candidate group of sensitivity factors that a subject has;a positive/negative analysis unit to judge from information obtained from the subject, whether an inner state of the subject is a positive pleasant state or a negative unpleasant state; anda comprehensive evaluation unit to integrate analysis results of the biological data analysis unit and the positive/negative analysis unit to estimate sensitivity comprehensively,wherein:the candidate group of sensitivity factors are candidate groups associated with an active degree of the sympathetic nervous system and/or the parasympathetic nervous system,wherein:the candidate groups include a plurality of sensitivity factors in the form of a set of positive and negative sensitivity factors.2. A sensitivity evaluation system according to claim 1 , wherein the acquisition unit acquires the reaction of the sympathetic nervous system and/or the reaction of the parasympathetic nervous system from different living ...

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18-04-2013 дата публикации

SAMPLING AND TESTING DEVICE FOR THE HUMAN OR ANIMAL BODY

Номер: US20130096400A1
Принадлежит: RESPIRIO PTY LTD

A device () is provided that is configured to indicate the presence or absence of one or more biological entities in a biological sample. The device comprises a sampling portion (), the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; and a test portion () in fluid engagement with the sampling portion, the test portion comprising one or more test zones (). The sampling portion and test portion are configured such that at least a portion of the sample received by the sampling portion is transferable to the test portion such as to contact one or more of the test zones, and wherein each test zone is configured to indicate the presence or absence of one or more biological entities in the sample. 1. A device comprising:a substantially rigid housing;a sampling portion located outside the housing, the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; anda test portion located at least partially inside the housing and in fluid engagement with the sampling portion, the test portion comprising one or more test zones,wherein the sampling portion and the test portion are configured such that at least a portion of the biological sample received by the sampling portion is transferable to the test portion by capillary action such as to contact one or more of the test zones, and wherein each of the one or more test zones is configured to indicate a presence or absence of one or more biological entities in the biological sample.2. The device of claim 1 , wherein the biological sample comprises any one or more of the following: blood claim 1 , serum claim 1 , plasma claim 1 , saliva claim 1 , sputum claim 1 , urine ...

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18-04-2013 дата публикации

Method for detecting temple hot spot temperature of a live body

Номер: US20130096437A1
Автор: Vincent Weng
Принадлежит: Radiant Innovation Inc

The present invention discloses a method for detecting temple hot spot temperature of a live body. Firstly, an infrared thermometer is used to continuously scan a temple of testee's forehead to obtain a plurality of measured infrared signals. Next, the measured infrared signals are sequenced from a greatest to a smallest measured infrared signal. Two output infrared signals closest to the greatest measured infrared signal are selected from the sequenced infrared signals. An average signal value is worked out from the selected infrared signals. Then, the average signal value is converted into a temple hot spot temperature of the testee's forehead. Thereby, not only the test result is more precise, but also the testee can learn the test result sooner.

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25-04-2013 дата публикации

Drains for Use in Medical Applications and Methods of Using the Same

Номер: US20130102860A1
Автор: Nishtala Vasu
Принадлежит: C. R. BARD, INC.

A drain for use in medical applications may include an elongated conduit configured to be implanted in a body cavity, wherein the conduit has a proximal end and a distal end. The conduit may include at least one channel configured to drain fluid from the body cavity and at least one lumen extending from the proximal end to the distal end of the conduit. The lumen may be at least partially surrounded by the at least one channel and may be separated from the at least one channel by a wall. At least one hole in the wall may be configured to provide fluid communication between the lumen and the at least one channel. 1. A drain for use in medical applications , comprising: at least one channel configured to drain fluid from the body cavity;', 'at least one lumen extending from a proximal end of the conduit to a distal end of the conduit, the lumen at least partially surrounded by the at least one channel and separated from the at least one channel by a wall; and', 'at least one opening in the wall establishing fluid communication between the lumen and the at least one channel., 'an elongated conduit configured to be implanted in a body cavity, the conduit comprising2. The drain according to claim 1 , further comprising a first channel wall claim 1 , a second channel wall claim 1 , and a third channel wall together defining three channels having substantially the same cross-sectional area.3. The drain according to claim 1 , wherein the conduit comprises at least one slot providing fluid communication between the at least one channel and an exterior of the conduit.4. The drain according to claim 1 , wherein the wall at the distal end of the conduit comprises a material that permits diffusion of at least one fluid from the lumen to the at least one channel.5. The drain according to claim 1 , further comprising a light source in the lumen at a location proximal the distal end of the conduit claim 1 , the light source being configured to illuminate a desired location in the ...

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25-04-2013 дата публикации

Micro Vein Enhancer

Номер: US20130102905A1

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

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25-04-2013 дата публикации

ILLUMINATOR FOR PHOTODYNAMIC THERAPY

Номер: US20130102906A1
Принадлежит:

An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes. 1. A method of photodynamically diagnosing or treating a patient , comprising:illuminating the patient with an illuminator whose measured output over an active emitting area is at least 60% of the measured maximum over all operation distances.2. The method according to claim 1 , wherein the illuminator is configured such that the measured output over the active emitting area is at least 70% of the measured maximum at distances of 4″ and 2″.3. The method according to claim 1 , wherein the illuminator comprises fluorescent tubes.4. The method according to claim 1 , wherein the spectral output of the illuminator substantially matches the absorption spectrum of protoporphyrin IX.5. The method according to claim 1 , wherein the illuminator generates light substantially entirely within the blue region.6. The method according to claim 1 , wherein the illuminator has a nominal peak wavelength of 417±5 nanometers and a nominal bandwidth of 30 nanometers.7. The method according to claim 1 , comprising illuminating the patient to treat actinic keratosis.8. The method according to claim 1 , comprising illuminating the patient to treat acne.9. The method according to claim 1 , comprising illuminating the patient to treat photo damaged skin.10. The method according to claim ...

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25-04-2013 дата публикации

Biological photometric device and biological photometry method using same

Номер: US20130102907A1
Принадлежит: Hitachi Medical Corp

The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

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02-05-2013 дата публикации

System, method and computer-accessible medium for performing attenuation-corrected multispectral luminescenece tomography of cerenkov and bioluminescent light sources

Номер: US20130108132A1
Автор: Alexander Klose
Принадлежит: Columbia University of New York

The present disclosure can provide apparatus, system, methods, and computer-accessible medium for generating particular information which is at least one of three-dimensional information or intensity information of a tissue portion which can include at least one of a tissue surface or a tissue volume. For example, the exemplary method can include determining a light intensity distribution of light provided on the tissue portion, using the light intensity distribution, determining one or more attenuation maps of the tissue portion, obtaining one or more multispectral measurements of the light intensity distribution on the tissue portion taken from one or more views, and generating the particular information using an image reconstruction procedure in conjunction with data from the one or more tissue attenuation maps and the multispectral measurements.

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02-05-2013 дата публикации

MONOLITHIC DEVICE

Номер: US20130109975A1

A monolithic device for the non-invasive measurement of optical parameters relating to a biological tissue comprising: at least one light emitter that emits light having a range of wavelengths and/or at least one detector for detecting light in a range of wavelengths transmitted or backscattered by the tissue, wherein one or more structures with sub-wavelength features is formed on the at least one emitter and/or the at least one detector. 1. A monolithic device for non-invasive measurement of optical parameters relating to a biological tissue , the monolithic device comprising at least one of:at least one light emitter that emits light having a range of wavelengths orat least one detector for detecting light in a range of wavelengths transmitted or backscattered by the tissue, wherein one or more structures with sub-wavelength features is formed on the at least one light emitter or the at least one detector.2. A device as claimed in wherein at least two light emitters are provided on the monolithic device.3. A device as claimed in wherein the sub-wavelength features on the at least two emitters are such that light emitted by the at least two emitters is of different wavelengths.4. A device as claimed in wherein at least two detectors are provided on the monolithic device.5. A device as claimed in wherein the at least one light emitter and the at least one detector are provided on the monolithic device.6. A device as claimed in wherein the at least one light emitter and the at least one detector are made of different material.7. A device as claimed in wherein the at least one light emitter or the at least one detector comprise semiconductor material.8. A device as claimed in wherein the semiconductor material is inorganic.9. A device as claimed in wherein the at least one light emitter or the at least one detector comprise emitting or absorbing dyes.10. A device as claimed in wherein the sub-wavelength features form part of one or more gratings.11. A device as ...

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02-05-2013 дата публикации

UV IMAGING FOR INTRAOPERATIVE TUMOR DELINEATION

Номер: US20130109977A1
Принадлежит: California Institute of Technology

A medical imaging system and method. A UV/visible camera uses a back illuminated silicon imaging detector to observe a surface of a brain of a human subject in vivo during brain surgery for excision of a cancerous tumor. The detector can be a CCD detector or a CMOS detector. Under UV illumination, the camera can record images that can be processed to detect the location and extent of a cancerous tumor because the presence of auto-fluorescent NADH variations can be detected between normal and cancerous cells. The image data is processed in a general purpose programmable computer. In some instances, an image is also taken using visible light, and the identified cancerous region is displayed as an overlay on the visible image. 1. A medical imaging system , comprising:a camera having a back illuminated silicon imaging detector that is sensitive in the visible and in the UV portions of the electromagnetic spectrum, said camera having a filter with a pass band in the UV, said filter being controllable to allow said camera to receive UV without visible illumination when said filter is engaged, and being controllable to allow said camera to receive visible illumination when said filter is removed from an optical path, said camera having at least one control port and having at least one output port;as required if not already present in a location of use, a UV illumination source configured to illuminate the field of operation in a surgical procedure on a brain of a patient, said UV illumination source, if provided, controllable by a controller;a controller configured to control an operation of said camera having said detector and said filter with said pass band in the UV; anda general purpose programmable computer configured to receive output data from said at least one output port of said camera having said detector, said general purpose programmable computer having access to instructions recorded on a machine readable medium, such that when the instructions are operating, ...

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09-05-2013 дата публикации

RENAL FUNCTION ANALYSIS METHOD AND APPARATUS

Номер: US20130116518A1

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule. 130-. (canceled)31. An apparatus for analyzing the condition of a kidney , said apparatus comprising:a source of a kidney function analysis composition, said composition comprising a plurality of fluorescent reporter molecules and a plurality of fluorescent marker molecules, said reporter molecules and said marker molecules sharing a molecular property;a catheter for introducing the analysis composition into the blood steam of a patient; anda detector for monitoring the level of the analysis composition within the blood stream and reporting the operating condition of the kidney;wherein the volume of plasma distribution based on the fluorescent of the marker molecules relative to the fluorescence of the reporter molecules is calculated and reported as a measure of kidney function and condition.32. The apparatus of wherein the molecular property is selected from the group consisting of molecular weight claim 31 , size claim 31 , shape claim 31 , charge claim 31 , fluorescence and radio frequency.33. The apparatus of wherein the molecular property is fluorescence claim 32 , the reporter molecule has a first fluorescence claim 32 , and the marker molecule has a second fluorescence.34. The apparatus of wherein the molecular property is molecular weight claim 32 , the reporter molecule has a first molecular weight claim 32 , and the marker molecule has a second molecular weight which is greater than the molecular weight of ...

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09-05-2013 дата публикации

DUAL PRESSURE SENSOR SIGNAL CHAIN TO REMOVE MUTUALLY-COUPLED MRI INTERFERENCE

Номер: US20130116544A1
Автор: Cates Harold, Rey Eduardo
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

Apparatus and methods provide a physiological status sensing device () for sensing a physiological status of a patient () and minimizing an amount of interference () generated during a resonance (MR) scan by a magnetic resonance (MR) system (). The device () includes a first, active sensor () located to sense the physiological status and experience MR scan related interference and to generate a first signal () having a physiological status component () and an interference component (). A second non-active sensor () is located closely adjacent to the first sensor () to experience substantially the same MR scan related interference () as the first sensor () and generate a second signal () having only the interference component (). A circuit or processor () subtractively combines the first () and second signals () to cancel the interference component (). 1. A physiological status sensing device for sensing a physiological status of a patient and minimizing an amount of interference generated during a magnetic resonance (MR) scan by a magnetic resonance (MR) system , the device comprising:a first, active sensor located to sense the physiological status and experience MR scan related interference and to output a first signal having a physiological status component and an interference component;a second, non-active sensor located closely adjacent to the first sensor to experience substantially the same MR scan related interference as the first sensor and output a second signal having the interference component; anda circuit which subtractively operates on the first and second signals to cancel the interference component.2. The device according to claim 1 , wherein the first sensor includes a first piezoresistive pressure transducer which senses a pressure related to the physiological status and the second sensor includes a second piezoresistive pressure transducer of like construction with the first piezoelectric pressure transducer claim 1 , the second pressure ...

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09-05-2013 дата публикации

IMPLANTABLE IMAGING ARRANGEMENT AND METHOD FOR USING THE SAME

Номер: US20130116552A1
Принадлежит:

According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for obtaining information associated with at least one anatomical structure. The exemplary apparatus can include at least one first arrangement which can be configured to provide at least one electro-magnetic radiation to at least one portion of the at least one anatomical structure. The first arrangement(s) can include a configuration which is configured to relatively permanently attach the apparatus to or in the at least one anatomical structure. The exemplary apparatus can further include at least one interferometric arrangement configured to receive a further radiation from the portion(s) which can be associated with the electro-magnetic radiation(s). 1. An apparatus for obtaining information associated with at least one anatomical structure , comprising:at least one first arrangement which is configured to provide at least one electro-magnetic radiation to at least one portion of the at least one anatomical structure, wherein the at least one first arrangement includes a configuration which is configured to relatively permanently attach the apparatus to or in the at least one anatomical structure; andat least one interferometric arrangement configured to receive a further radiation from the at least one portion which is associated with the at least one electro-magnetic radiation.2. The apparatus according to claim 1 , wherein the configuration includes at least one of a suction arrangement claim 1 , a hooking arrangement claim 1 , an adhesive arrangement or a surface tension arrangement.3. The apparatus according to claim 1 , wherein the at least one first arrangement includes a beam scanning arrangement.4. The apparatus according to claim 3 , wherein the beam scanning arrangement includes a micro electro-mechanical system (MEMS).5. The apparatus according to claim 3 , wherein the beam scanning arrangement includes a Risley prism arrangement.6. The apparatus ...

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09-05-2013 дата публикации

Biological measuring apparatus and biological measuring method

Номер: US20130116553A1
Принадлежит: Canon Inc

A biological measuring apparatus measures physical parameters in a part of a living body by diffuse optical tomography. The apparatus includes at least one first light source and one first detector both disposed inside the living body, at least one second light source and one second detector both disposed outside the living body. A processor processes measured values and reconstructs the distribution of scattering coefficients or absorption coefficients of light interacting with the living body. The measured values are acquired from at least one measurement light beam emitted from the first light source and detected by one of the first and second detectors, and at least one measurement light beam emitted from the second light source and detected by one of the first and second detectors.

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09-05-2013 дата публикации

THREE-DIMENSIONAL THERMAL IMAGING FOR THE DETECTION OF SKIN LESIONS AND OTHER NATURAL AND ABNORMAL CONDITIONS

Номер: US20130116573A1
Автор: Herman Cila
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

A thermal imaging system includes a data processing system and a geometrical scanning system constructed to communicate with the data processing system. The geometrical scanning system is adapted to scan at least a section of a surface of a subject under observation. The thermal imaging system also includes an infrared imaging system constructed to communicate with the data processing system. The infrared imaging system is adapted to image at least a portion of the section of the surface of the subject under observation. The data processing system is configured to receive data from the geometrical scanning system and to construct a surface map of the section of the surface of the subject under observation and to identify geometrical markers on the surface map based on the data from the geometrical scanning system. The data processing system is also configured to receive data from the infrared imaging system and to construct a thermal map of the portion of the section of the surface, to identify thermal markers on the thermal map based on the data from the infrared imaging system, and to register the thermal map to the surface map based on a correspondence between at least some of the geometrical and thermal markers. The data processor is configured to correct temperatures of the thermal map based on the surface map subsequent to the registering. 1. A thermal imaging system , comprising:a data processing system;a geometrical scanning system constructed to communicate with said data processing system, said geometrical scanning system being adapted to scan at least a section of a surface of a subject under observation; andan infrared imaging system constructed to communicate with said data processing system, said infrared imaging system being adapted to image at least a portion of said section of said surface,wherein said data processing system is configured to receive data from said geometrical scanning system and to construct a surface map of said section of said ...

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09-05-2013 дата публикации

METHOD FOR ASCERTAINING SPATIAL COORDINATES

Номер: US20130116574A1
Принадлежит: NAVISWISS AG

The invention relates to a method for ascertaining spatial coordinates in which at least two markers are put on a living being and at least two cameras in a stereo arrangement are used to ascertain the spatial coordinates of the markers, wherein the spatial coordinates of the markers are compared with a reference and the difference is calculated and output. The invention also relates to quantitative length and angle measurements using optical, stereometric measurement systems for medical applications. 1. A method for determining spatial coordinates , in which at least two markers are made on a living creature and the spatial coordinates of these markers are determined using at least two cameras in a stereo arrangement , wherein the spatial coordinates of the markers are compared with a reference and the deviation is calculated and output.2. The method according to claim 1 , wherein the spatial coordinates are determined at least before and after a change in the distance between the markers caused by a treatment of the living creature.3. The method according to claim 2 , wherein the living being is positioned differently in space before the treatment in comparison with after the treatment.41. The method according to Claim claim 2 , wherein additional markers are made on the living creature during the treatment.5. The method according to claim 1 , wherein the change in the distance between two markers is calculated from the spatial coordinates.6. The method according to claim 1 , wherein the change in the angle between the three markers is calculated from the spatial coordinates.7. The method according to claim 1 , wherein the markers are made on the skin of the living creature.8. The method according to claim 1 , wherein the markers are made above significant bone points of the living creature.9. The method according to claim 1 , wherein a change in a length or a change in an angle is determined by comparison with a reference.10. The method according to claim 1 , ...

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16-05-2013 дата публикации

Medical Workflow System and Method

Номер: US20130123616A1
Принадлежит: VOLCANO CORPORATION

A method of conducting a medical workflow with a touch-sensitive bedside controller is disclosed. The method includes initiating a medical workflow using a graphical user interface on the bedside controller, positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller, controlling the commencement and termination of a recordation of images captured by the imaging tool using the graphical user interface on the bedside controller, navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller, and performing measurements on the image of interest using the graphical user interface on the bedside controller. 1. A method of conducting a medical workflow with a touch-sensitive bedside controller , the method comprising:initiating a medical workflow using a graphical user interface on the bedside controller;positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller;controlling the initiation and termination of a recordation of images by the imaging tool using the graphical user interface on the bedside controller;navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller; andperforming measurements on the image of interest using the graphical user interface on the bedside controller.2. The method of claim 1 , wherein the initiating includes selecting the medical workflow out of a plurality of medical workflows presented as selectable options within the graphical user interface.3. The method of claim 2 , wherein the plurality of medical workflows includes two or more of an intravascular ultrasound (IVUS) imaging workflow claim 2 , an intravascular photoacoustic (IVPA) imaging workflow claim 2 , an optical coherence tomography (OCT) workflow claim 2 , a forward looking IVUS (FL- ...

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16-05-2013 дата публикации

MEASURING METHOD OF LIFE ACTIVITY, MEASURING DEVICE OF LIFE ACTIVITY, TRANSMISSION METHOD OF LIFE ACTIVITY DETECTION SIGNAL, OR SERVICE BASED ON LIFE ACTIVITY INFORMATION

Номер: US20130123639A1
Автор: Ando Hideo
Принадлежит:

According to a measuring method or a control method of life activity, a life object is illuminated with an electromagnetic wave including a wavelength in a designated waveband, and a characteristic in a local area of the life object is detected, or a life activity thereof is controlled. This “local area” is an area constituted by one or more cells. The “designated waveband” is defined based on any one of the following phenomena: 1. A detecting method of life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; anddetecting the activity at least in a local area in the life object.2. A controlling method of life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; andcontrolling the activity at least in a local area in the life object.3. A transmission method of information related to life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; andtransmitting information obtained on the basis of detection of the activity at least in a local area in the life object.4. The detecting method of life activity according to claim 1 , wherein:the designated waveband relates to a wavelength of not less than 0.84 μm but not more than 110 μm.5. The detecting method of life activity according to claim 1 , whereinthe designated peak relates to a chemical shift value in a range of not less than δ1.7 ppm but not more than δ4.5 ppm.6. The designated method of life activity according to claim 1 , whereinthe designated waveband is determined on the basis of transition energy between a plurality of states constituted by a specific ground state in the local area which ground state is able to ...

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16-05-2013 дата публикации

Scanned Laser Vein Contrast Enhancer

Номер: US20130123640A1
Принадлежит:

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head, The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like. 1138-. (canceled)139. A portable handheld vein enhancing device , for use in imaging one or more subcutaneous blood vessels of a target surface , said portable handheld vein enhancing device comprising:a laser configured to alternately emit a first wavelength of light and a second wavelength of light within a single beam, said second wavelength of light being a visible wavelength of light;one or more movable mirrors configured to receive said beam of light from said laser and to selectively move to cause said beam of light to be transmitted onto the target surface in a pattern;one or more photo detectors configured to detect said first wavelength of light after being reflected from the target surface as a contrasted image formed by differential amounts of absorption and reflection between the one or more subcutaneous blood vessels and the surrounding tissue therein; said one or more photo detectors further configured to output a signal representing said contrasted image; andwherein said laser is configured to be responsive to said signal outputted by said one or more photo detectors, and to project said contrasted image ...

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16-05-2013 дата публикации

ESTIMATING APPARATUS AND ESTIMATING METHOD

Номер: US20130123642A1
Принадлежит:

A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue. 1. An estimating apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical , the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence , with the excitation light emitted from a tip portion of a laser catheter , comprising:a connector to/from which the laser catheter is capable of being attached/detached;a light source for outputting the excitation light to the laser catheter via the connector; anda detection unit for detecting intensity of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue.2. The estimating apparatus according to claim 1 , whereinthe detection unit detects intensity of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to simultaneously estimate whether the tissue has changed because of reaction ...

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16-05-2013 дата публикации

METHOD AND ELECTRONIC DEVICE FOR REMOTE DIAGNOSIS

Номер: US20130123646A1
Автор: Choi Kyuhyoung
Принадлежит: LG ELECTRONICS INC.

The present invention relates to a remote treatment method and an electronic device. More specifically, the present invention provides a remote treatment method and an electronic device that guide a manipulation of a checkup tool. 1. An electronic device comprising:an output unit configured to output an image of a treatment target;a communication unit configured to receive medical information including information regarding a checkup part of the treatment target from an external device; anda controller configured to obtain a first area corresponding to the checkup part in the image of the treatment target based on the received medical information, andthe controller configured to control the output unit to display a first indicator reflecting the checkup part on the first area to overlap the output image of the treatment target.2. The electronic device of claim 1 , wherein the controller obtains information regarding a position of a checkup tool and controls the output unit to output an alarm signal when at least a portion of the checkup tool is included in the first area based on the information regarding the position of the checkup tool claim 1 , and wherein the alarm signal includes at least one of a visual signal claim 1 , an auditory signal claim 1 , and a tactile signal.3. The electronic device of claim 1 , wherein the controller obtains information regarding a position of a checkup tool and controls the output unit to output information for guiding a manipulation of the checkup tool based on a relative position between the position of the checkup tool and the first area.4. The electronic device of claim 3 , wherein the information for guiding the manipulation of the checkup tool includes information indicating at least one of a shift direction and a shift distance of the checkup tool when the position of the checkup tool is inconsistent with the first area.5. The electronic device of claim 1 , wherein the controller obtains information regarding a position of ...

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23-05-2013 дата публикации

Automatic detection by a wearable camera

Номер: US20130128051A1
Принадлежит: SYRACUSE UNIVERSITY

There is set forth herein a system including a camera device. In one embodiment the system is operative to perform image processing for detection of an event involving a human subject. There is set forth herein in one embodiment, a camera equipped system employed for fall detection.

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23-05-2013 дата публикации

OPTICAL TOMOGRAPHY IMAGE ACQUISITION DEVICE

Номер: US20130130191A1
Принадлежит:

The optical tomography image acquisition device comprises a tomographic image computer () that produces tomographic image information about a measurement object, a measurement distance range deviation detector () that detects that the distance between a measurement object and the light input/output portion () of a probe is outside a measurement distance range on the basis of the computation result of the tomographic image computer (), and a display controller () that outputs the computation result of the tomographic image computer () to a display component () and also sends the detection result of the measurement distance range deviation detector () to the display component (). 1. An optical tomography image acquisition device , comprising:a light source;a splitter configured to split light emitted from the light source into a first direction and a second direction;a probe has a light input/output portion configured to direct first light split off in the first direction toward a measurement object, and take in reflected light from the measurement object as measurement light;a reference mirror configured to perform path correction on second light split off in the second direction at the splitter;an interference section configured to produce interference light by causing interference between the second light that has undergone path correction at the reference mirror and the first light taken in as measurement light to the probe;a tomographic image computer configured to produce tomographic image information about a measurement object by computational processing of interference light produced at the interference section;a measurement distance range deviation detector configured to detect whether or not the distance between the measurement object and the light input/output portion of the probe is outside of a measurement distance range on the basis of the computation result of the tomographic image computer; anda notification section configured to notify of the ...

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23-05-2013 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR IDENTIFYING PORTIONS OF A WOUND FILLER LEFT AT A TISSUE SITE

Номер: US20130131471A1
Принадлежит: KCI Licensing, Inc.

Methods for treating a wound include positioning a wound filler having a coating agent containing a fluorescent material proximate the wound. The wound filler is removed after a time period. The wound is then scanned using a fluorescence scanner to determine whether a portion of the wound filler remains at the wound. In response to the portion of the wound filler remaining at the wound, the portion of the wound filler is removed. Other methods and systems are presented. 1. A method for treating a wound , the method comprising:positioning a wound filler having a coating agent containing fluorescent markers proximate the wound;removing the wound filler after a time period;scanning the wound using a fluorescence scanner to determine whether a portion of the wound filler remains at the wound; andresponsive to the portion of the wound filler remaining at the wound, removing the portion of the wound filler.2. The method of claim 1 , wherein the fluorescent markers are an ultraviolet dye and the fluorescence scanner is an ultraviolet scanner.3. The method of claim 1 , wherein the fluorescent markers are an infrared dye and the fluorescence scanner is an infrared scanner.4. The method of claim 3 , wherein the step of scanning the wound comprises emitting claim 3 , with the fluorescence scanner claim 3 , infrared light with wavelengths in a range of about 700 nm to 900 nm.5. The method of claim 1 , wherein the coating agent is applied to a surface of the wound filler.6. The method of claim 1 , wherein the coating agent is at least partially embedded within the wound filler.79.-. (canceled)10. The method of or any of the preceding claim 1 , farther comprising: applying reduced pressure to the wound filler prior to removing the wound filler.11. The method of claim 1 , wherein the wound filler is a first wound filler claim 1 , the method further comprising:responsive to scanning the wound and finding that the first wound filler has been completely removed, positioning a second ...

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23-05-2013 дата публикации

Multimodal detection of tissue abnormalities based on raman and background fluorescence spectroscopy

Номер: US20130131488A1
Принадлежит: British Columbia Cancer Agency BCCA

Methods and apparatus for classifying tissue use features of Raman spectra and background fluorescent spectra. The spectra may be acquired in the near-infrared wavelengths. Principal component analysis and linear discriminant analysis of reference spectra may be used to obtain a classification function that accepts features of the Raman and background fluorescence spectra for test tissue and yields an indication as to the likelihood that the test tissue is abnormal. The methods and apparatus may be applied to screening for skin cancers or other diseases.

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23-05-2013 дата публикации

MEDICAL INSTRUMENT WITH PROBE, PROBE COVER, AND METHODS OF USING THE SAME

Номер: US20130131518A1
Принадлежит: WELCH ALLYN, INC.

A medical instrument including a probe adapted to be inserted into an orifice of an animal's body. The instrument includes an emitter of electromagnetic radiation that is sensed by a sensor mounted on the probe. The sensor can then determine, by variations in the amount of radiation received from the emitter, whether a probe cover is mounted over the probe. A sensor can also be used to determine whether the walls of the body orifice block the radiation received from the emitter, thereby indicating position of the sensor, and thus, the probe within the orifice. A special probe cover is disclosed, and methods of using the medical instrument are also disclosed. 1. A medical instrument includinga support structure;a probe attached on said support structure, said probe possessing an outer peripheral surface and adapted to be inserted into an orifice in an animal's body;a sensor adapted to sense electro-magnetic radiation from a source of said radiation remote from the animal's body, said sensor mounted on said outer peripheral surface of said probe in a position so as to receive said radiation; anda microprocessor operatively connected to said sensor, said microprocessor configured to monitor the magnitude of said radiation sensed by said sensor and to evaluate the degree of any reduction of said monitored magnitude as an indication of the insertion of said probe into the body orifice.2. The medical instrument according to wherein said radiation is substantially different from ambient radiation present in the vicinity of said medical instrument.3. The medical instrument according to wherein said radiation includes ambient radiation in the vicinity of said medical instrument.4. The medical instrument according to wherein said radiation is substantially outside the visible spectrum.5. The medical instrument according to wherein said radiation is substantially within the visible spectrum.6. The medical instrument according to wherein said support structure includes a head ...

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23-05-2013 дата публикации

LIGHT-GUIDING DEVICES AND MONITORING DEVICES INCORPORATING SAME

Номер: US20130131519A1
Принадлежит: Valencell, Inc.

A monitoring device configured to be attached to the ear of a person includes a base, an earbud housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a cover surrounding the earbud housing. The base includes a speaker, an optical emitter, and an optical detector. The cover includes light transmissive material that is in optical communication with the optical emitter and the optical detector and serves as a light guide to deliver light from the optical emitter into the ear canal of the subject wearing the device at one or more predetermined locations and to collect light external to the earbud housing and deliver the collected light to the optical detector. 1. A headset , comprising:a housing configured to be positioned within an ear of a subject;an optical emitter and an optical detector; andat least one light guide associated with the housing, wherein the at least one light guide comprises a distal end configured to engage a portion of the ear of the subject, wherein the at least one light guide is in optical communication with the optical emitter or optical detector, and wherein the at least one light guide is configured to deliver light from the optical emitter into an ear region of the subject via the distal end or collect light from an ear region of the subject via the distal end and deliver collected light to the optical detector.2. The headset of claim 1 , wherein at least a portion of the distal end of the at least one light guide extends outwardly from the housing.3. The headset of claim 1 , wherein the at least one light guide comprises optical filtering material.4. The headset of claim 1 , wherein the at least one light guide comprises light transmissive material with a refractive index of at least one (1).5. The headset of claim 1 , wherein the at least one light guide comprises an elastomeric light transmissive material.6. The headset of claim 1 , wherein the at least one light guide comprises a ...

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30-05-2013 дата публикации

METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD

Номер: US20130137944A1
Принадлежит: SNU R&DB FOUNDATION

Method pertains to a medical imaging device for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets. The method includes: injecting at least one marker particle including Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time. 1. A method for simultaneously detecting fluorescence and Raman signals for multiple targets , the method comprising steps of:injecting one or more marker particles including therein Raman marker material and receptors into a body of an animal including human;emitting a laser light into the body of the animal; anddetecting the fluorescence signals and the Raman signals separately from the optical signals emitted after the injecting.2. The method as set forth in claim 1 , wherein the detecting step comprises steps of:removing, by filtering, the laser light from the emitted optical signals;separating a path of the filtered optical signals into a first path and a second path; anddetecting the fluorescence signals from the optical signals of the separated first path, and detecting the Raman signals from the optical signals of the separated second path.3. The method as set forth in claim 1 , wherein the injecting step comprises directly spraying the marker particles onto a test structure inside the body ...

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30-05-2013 дата публикации

Systems and Methods for Hyperspectral Medical Imaging

Номер: US20130137961A1
Принадлежит:

Under one aspect, an apparatus for analyzing the skin of a subject includes a hyperspectral sensor for obtaining a hyperspectral image of the subject. The apparatus further includes a control computer that is in electronic communication with the hyperspectral sensor and which controls at least one operating parameter of the hyperspectral sensor. The control computer includes a processor unit and a computer readable memory. The memory includes executable instructions for controlling the at least one operating parameter of the hyperspectral sensor. The memory includes executable instructions for applying a wavelength dependent spectral calibration standard constructed for the hyperspectral sensor to a hyperspectral image collected by the hyperspectral sensor. The apparatus further includes a light source that illuminates the skin of the subject for the hyperspectral sensor. 1. An apparatus for analyzing the skin of a subject , the apparatus comprising:(A) a hyperspectral sensor that is configured to take a hyperspectral image of the skin of said subject; (i) executable instructions for controlling said at least one operating parameter of the hyperspectral sensor; and', '(ii) executable instructions for applying a wave-length dependent spectral calibration standard constructed for the hyperspectral sensor to a hyperspectral image collected by the hyperspectral sensor; and, '(B) a control computer for controlling the hyperspectral sensor, wherein the control computer is in electronic communication with the hyperspectral sensor and wherein the control computer controls at least one operating parameter of the hyperspectral sensor, and wherein the control computer comprises a processor unit and a computer readable memory comprising(C) a light source that illuminates the skin of the subject for the hyperspectral sensor.2. The apparatus of claim 1 , wherein the at least one operating parameter is a sensor control.3. The apparatus of claim 1 , wherein the at least one ...

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30-05-2013 дата публикации

HANDHELD SKIN MEASURING OR MONITORING DEVICE

Номер: US20130137991A1
Принадлежит:

A handheld skin monitoring or measuring device includes a camera having a camera optical axis; and a structured light arrangement configured to project three or more laser fan beams such that the laser fan beams cross at a crossing point in front of the camera. 1. A handheld skin monitoring or measuring device , including:a camera having a camera optical axis; anda structured light arrangement configured to project three or more laser fan beams such that the laser fan beams cross at a crossing point in front of the camera.2. A handheld skin monitoring or measuring device as claimed in wherein the structured light arrangement is configured to project the laser fan-beams such that a pattern formed by the laser fan-beams on a skin surface varies with a distance between the device and the skin surface claim 1 , and wherein the pattern is a predetermined pattern when the device is at a distance from the skin surface within an optimum range claim 1 , such that a user is enabled to position the handheld skin monitoring or measuring device at a distance from the skin surface within the optimum range by adjusting the distance such that the predetermined laser pattern is formed on the surface.3. A handheld skin monitoring or measuring device as claimed in wherein the predetermined pattern includes the laser fan-beams crossing at the crossing point claim 2 , and a user is enabled to position the handheld skin monitoring or measuring device at a distance from a skin surface within an optimum range by aligning the crossing point with the skin surface.4. A handheld skin monitoring or measuring device as claimed in wherein the camera has a camera field of view and the three or more laser fan beams subtend fan beam angles corresponding to the camera field of view claim 1 , such that the ends of the laser beams projected onto a skin surface define a region that substantially corresponds to an image frame of the camera.5. A handheld skin monitoring or measuring device as claimed in ...

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06-06-2013 дата публикации

NMR SYSTEMS FOR IN VIVO DETECTION OF ANALYTES

Номер: US20130144134A1
Принадлежит: T2 Biosystems, Inc.

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response. 1. A nuclear magnetic resonance system for assessing the presence or concentration of an analyte contained in a body fluid of a mammal in-vivo , the system comprising:(a) a sensor suitable for partial or complete implantation within the mammal's body, the sensor comprising structure defining a sample volume and a port, the sample volume containing magnetic particles, and the port allowing the analyte to enter the sample volume and preventing, partly or completely, the magnetic particles from leaving the sample volume, the extent of aggregation of the magnetic particles being indicative of the presence or concentration of the analyte in the sample volume;(b) a reader for disposition outside the mammal's body, the reader providing results based on sensor indication of presence or concentration of the analyte in the sample volume;(c) a magnet or magnetic field generator;(d) a radiofrequency coil for applying a radiofrequency pulse sequence to the sample volume in the presence of a magnetic field provided by the magnet or magnetic field generator; and(e) means for determining the position of the sensor within the mammal's body.2. The system of claim 1 , wherein the radiofrequency coil acts as a sensing radiofrequency coil and an excitation radiofrequency coil.3. The system of claim 1 , wherein the sensor comprises the radiofrequency coil of (d) or a further radiofrequency coil.4. The system of claim 1 , wherein the reader comprises the radiofrequency coil of (d) or a ...

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06-06-2013 дата публикации

System and Method For Determining Modified States of Health of Living Tissue

Номер: US20130144151A1
Принадлежит: PURDUE RESEARCH FOUNDATION

A phenotypic profiling method for drug/dose physiological response of living bodies utilizes feature recognition to segment the information in time-frequency tissue-response spectrograms to construct N-dimensional feature vectors. The feature vectors are used to generate a correlation matrix among a large number of different stimuli in the form of drugs, doses and conditions. Multi-dimensional scaling is applied to the correlation matrix to form a two-dimensional map of response relationships that retains rank distances from the higher-dimensionality feature matrix. The two-dimensional phenotypic profile space displays compact regions indicative of particular physiological responses, such as regions of enhanced active transport, membrane undulations and blebbing. 1. A method for creating a phenotypic profile useful for drug screening , comprising:generating a spectrogram of a differential dynamic physiological response of a living body to a stimuli, including a new drug and condition; andgenerating a feature vector whose elements are obtained by an inner product between a feature mask and the spectrogram, in which the feature mask corresponds to a known response at an isolated region of a frequency-time spectrogram.2. The method of claim 1 , wherein the frequencies in the feature mask are obtained through an ensemble average over many spectrograms.3. The method of claim 2 , wherein the frequencies in the feature mask are obtained through a level-set approach that is averaged over many spectrograms.4. The method of claim 3 , wherein the level-set is set to zero.5. The method of claim 1 , wherein the feature masks are selected morphometrically using the spectrogram to define its own masked regions.6. The method of claim 1 , wherein quantitative index values are constructed from combinations of individual features.7. The method of claim 6 , wherein the quantitative index value is an apoptotic index representative of apoptotic activity in the living sample.8. The method ...

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06-06-2013 дата публикации

SLEEP APNEA DETECTION SYSTEM

Номер: US20130144190A1

This document provides methods and materials (e.g., systems) related to assessing sleep conditions (e.g., sleep apnea). 1. A method for assessing sleep of a human in a normal sleep environment , wherein said method comprises:(a) detecting audible sounds from said human in said normal sleep environment using a mobile electronic device having a sound sensor, and(b) determining whether said audible sounds are indicative of normal sleep or a disorder present in said human.28-. (canceled)9. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of normal sleep.10. (canceled)11. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of said disorder.1214-. (canceled)15. The method of claim 11 , wherein said method comprises informing said human via said mobile device that said human has said disorder.16. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of sleep apnea.17. The method of claim 16 , wherein said method comprises informing said human via said mobile device that said human has sleep apnea.18. The method of claim 1 , wherein said audible sounds comprise snores of said human claim 1 , and said determining step comprises assessing the amplitude of said snores claim 1 , the interval between said snores claim 1 , the frequency composition of snores claim 1 , or the duration of snores.19. The method of claim 1 , wherein said audible sounds comprise snores of said human claim 1 , and said determining step comprises assessing the amplitude of said snores claim 1 , the interval between said snores claim 1 , the frequency composition of snores claim 1 , and the duration of ...

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13-06-2013 дата публикации

Modular Headrest and Multi-Light Apparatus

Номер: US20130150683A1
Автор: Irwin N. Boe
Принадлежит: Individual

A multi-light apparatus ( 10 ) for primary use in dental or medicinal operatory workspaces and for interconnection with a modular operating chair ( 12 ), so as to form the headrest thereof, preferably includes first and second radiation sources ( 36,72 ) and a selection mechanism ( 70 ) for selecting a desired radiation source, a rigidly flexible light pipe ( 16 ) that may be alternatively coupled to each light source ( 36,72 ) and is configured to transmit selected radiation to a patient ( 14 ), a reflective surface ( 78 ) configured to direct the selected radiation to the pipe ( 16 ), a power supply ( 50 ), a cooling fan ( 56 ), and at least one potentiometer ( 66,68 ) for varying the voltage delivered to the sources ( 36,72 ) and fan ( 56 ).

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13-06-2013 дата публикации

MEDICAL INSTRUMENT

Номер: US20130150713A1
Автор: ONO Wataru, TAKEI Shunji
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP.

A medical instrument is provided with: an illumination section radiating excitation light for exciting a fluorescent substance given to a subject, to the subject; an image pickup section photoelectrically converting reflected light from the subject to which the excitation light is radiated, to pick up an image of the subject; a reading section holding pixel signals obtained by the photoelectrical conversion and capable of reading the pixel signals non-destructively while changing amplification factors of the held pixel signals by a predetermined unit of pixels; and an image processing section determining an arithmetic mean of the pixel signals read with different amplification factors by the reading section to generate an image. The medical instrument improves visibility of each fluorescent area without occurrence of position displacement even in the case where multiple fluorescent areas with a relatively large brightness/darkness difference exist within one screen. 1. A medical instrument comprising:an illumination section radiating excitation light for exciting a fluorescent substance given to a subject, to the subject;an image pickup section photoelectrically converting reflected light from the subject to which the excitation light is radiated, to pick up an image of the subject;a reading section holding pixel signals obtained by the photoelectrical conversion and capable of reading the pixel signals non-destructively while changing amplification factors of the held pixel signals by a predetermined unit of pixels; andan image processing section determining an arithmetic mean of the pixel signals read with different amplification factors by the reading section to generate an image.2. The medical instrument according to claim 1 , whereinthe reading section performs non-destructive reading multiple times, changing an amplification factor for each screen of the image pickup section.3. The medical instrument according to claim 2 , whereinthe reading section performs ...

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13-06-2013 дата публикации

METHOD FOR DETECTING HEMATOMA, PORTABLE DETECTION AND DISCRIMINATION DEVICE AND RELATED SYSTEMS AND APPARATUSES

Номер: US20130150726A1
Принадлежит:

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light. The near infrared light is emitted at two distances from a brain of the patient, so the emitted light penetrates to two different depths. Such a method also includes applying a ratiometric analysis to the reflected light to distinguish a border between normal tissue and tissue exhibiting blood accumulation. 1. A method for detecting a hematoma , comprising the step(s) of:emitting near infrared light and directing the emitted light towards tissue of a patient;measuring reflected light corresponding to two depths of penetration;obtaining a ratiometric measure of the reflected light corresponding to the two depths of penetration;determining from the obtained ratiometric measure at least the presence of a blood event, the blood event being representative of a blood-tissue injury.2. The method of claim 1 , further comprising the step(s) of:moving an emitter of the near infrared light and a reflected light detection section for detecting the reflected light along an external surface of the tissue; andperforming said steps of emitting, measuring and determining during said step of moving.3. The method of claim 1 , wherein said ratiometric measure is representative of a ratio of densities representing the reflected light of the two penetration depths.4. The method of claim 3 , wherein said determining includes evaluating the ratiometric measure to distinguish between normal tissue and tissue exhibiting blood accumulation.5. The method of claim 1 , wherein the blood event is at least one of an intracranial arachnoid hemorrhage a subdural hematoma or an epidural hematoma.6. The method of claim 1 , further comprising the step(s) ...

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13-06-2013 дата публикации

COOLING SYSTEM FOR A PHOTOCOSMETIC DEVICE

Номер: US20130150730A1
Принадлежит: PALOMAR MEDICAL TECHNOLOGIES, INC.

Photocosmetic device for use in medical or non-medical environments (e.g., a home, barbershop, or spa), which can be used for a variety of tissue treatments. Radiation is delivered to the tissue via optical systems designed to pattern the radiation and project the radiation to a particular depth. The device has a variety of cooling systems including phase change cooling solids and liquids to cool treated skin and the radiation sources. Contact sensors and motion sensor may be used to enhance treatment. The device may be modular to facilitate manufacture and replacement of parts. 1. A device for measuring the pigmentation level of skin , comprising:a handpiece adapted for contact with the skin;a light source configured to illuminate the skin;a contact sensor coupled to the handpiece, wherein the contact sensor is capable of determining if the handpiece is in contact with the skin; andan optical sensor coupled to the handpiece, wherein the optical sensor measures illumination reflected from the skin and is configured to calculate and output skin pigmentation level based on the measurement of illumination reflected from the skin, and wherein pigmentation level measurement is enabled when the contact sensor detects contact between the handpiece and the skin.2. The device of claim 1 , wherein the optical sensor is at least one of a CCD or a CMOS device.3. The device of claim 1 , wherein the contact sensor is at least one of an optical sensor claim 1 , an electrical sensor claim 1 , a mechanical sensor claim 1 , and a temperature sensor. This application is a continuation of application Ser. No. 13/443,381, (“the '381 application”), filed Apr. 10, 2012, which is a continuation of application Ser. No. 11/603,712 (“the '712 application”), filed Nov. 22, 2006, which is a continuation application of Ser. No. 10/154,756 (“the '756 application”), now U.S. Pat. No. 7,204,832, filed May 23, 2002, which claims priority to provisional application Ser. No. 60/363,798, filed Mar. 12, ...

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13-06-2013 дата публикации

OPTICAL FIBER ARRAY PROBE IMAGING SYSTEM INTEGRATED WITH ENDOSCOPE

Номер: US20130150731A1
Принадлежит: KOREA BASIC SCIENCE INSTITUTE

Provided is an imaging system which includes an optical fiber array probe unit integrated with an endoscope unit, thereby simultaneously measuring structural information and functional information of a sample. The optical fiber array probe unit includes an optical fiber array probe integrated with lenses including an optical fiber lens with a lens surface of a predetermined radius of curvature in which one ends of optical fibers are integrally connected with each other by heating a predetermined region including the one ends of two of the optical fibers using a heating means, as an optical fiber array probe integrated lens on which the light transmitted from the light source is incident and which guides light reflected from the sample, and a detector for selectively detecting the light transmitted from the optical fiber array probe integrated with lenses in a predetermined range of wavelength. 1. An optical fiber array probe imaging system integrated with an endoscope , comprising:an endoscope unit; andan optical fiber array probe unit integrated with lenses,wherein the endoscope unit includes a light source, an endoscope probe through which the light source is transmitted to a sample, and a detection unit for detecting light reflected in the endoscope probe, andwherein the optical fiber array probe unit integrated with lenses includesan optical fiber array probe integrated with lenses including an optical fiber lens with a lens surface of a predetermined radius of curvature in which one ends of optical fibers are integrally connected with each other by heating a predetermined region including the one ends of two of the optical fibers using a heating means, as an optical fiber array probe integrated lens on which the light transmitted from the light source is incident and which guides light reflected from the sample, and a detector for selectively detecting the light transmitted from the optical fiber array probe integrated with lenses in a predetermined range of ...

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20-06-2013 дата публикации

Rapid Diagnosis of A Disease Condition Using Infrared Spectroscopy

Номер: US20130153770A1
Принадлежит: The Ohio State University

Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals. 1. A method for rapidly diagnosing a disease condition , comprising:receiving a fluid biomedical specimen from a test subject;separating the specimen to obtain a desired fraction;depositing an aliquot of the desired fraction onto a slide;drying the aliquot;collecting infrared spectral data from the aliquot; andidentifying a test subject's condition by analyzing the infrared spectral data using multivariate classification models.2. The method of claim 1 , further comprising the step of:developing multivariate classification models using previously provided spectra corresponding to reference films of afflicted subjects and non-afflicted subjects.3. The method of claim 1 , whereinthe drying step further comprises the step of forming a dried film on the slide; andthe collecting step comprises obtaining infrared spectral data from at least two regions of the dried film.4. The method of claim 3 , further comprising the step of:diluting the specimen to form a specimen-water solution prior to the depositing step.5. The method of claim 4 , wherein:the specimen-water solution contains at least one part water for each part fluid specimen.6. The method of claim 1 , wherein:the separating ...

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20-06-2013 дата публикации

System for Glycated Protein Detection

Номер: US20130158374A1
Автор: Lou Reinisch
Принадлежит: VERITIDE Ltd

A method of detecting the presence of glycated proteins or peptides (GPs) in a sample comprises carrying out the steps of assessing the sample for fluorescence, subjecting the sample to UV radiation, and reassessing the sample for an increase in fluorescence relative to any fluorescence assessed in said first assessing step, an increase in fluorescence at said reassessing step being indicative of the presence of GPs. The method may be useful for detecting disease such as diabetes.

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20-06-2013 дата публикации

System For Diagnosing and Identifying Genetic Features, Genetic and Congenital Syndromes And Developmental Abnormalities

Номер: US20130158437A1
Автор: Moalem Sharon
Принадлежит:

The invention is a system for diagnosing and identifying of genetic characteristics, genetic syndromes, congenital syndromes, developmental and exposure related syndromes, and veterinary breed characteristics in fetuses, children and adults, in humans and animals. The system takes a set of facial anatomical measurements of an individual target and biological relatives of the individual target, normalizes the facial anatomical measurements, and compares the normalized measurements with a database of set of anatomical features associated with a desired diagnostic data set. 1. A system for the identification and diagnosis of genetic features , genetic syndromes , congenital and developmental abnormalities of a human or animal target , the system comprising:a first data collection module, capable of obtaining facial anatomical measurements of the target;a database of data correlating facial anatomical measurements with a diagnostic data set;a second data collection module, capable of obtaining facial anatomical measurements of biological relatives of the target;a data filter module, capable of comparing the target's facial anatomical measurements with the facial anatomical measurements of the biological relatives to produce a filtered set of target facial measurements;a data processing module, capable of comparing the filtered set of target facial anatomical measurements with the database; anda reporting module, capable of providing a report of the comparison.2. The system of claim 1 , where the diagnostic data set comprises genetic characteristics.3. The system of claim 1 , where the diagnostic data set comprises genetic syndromes.4. The system of claim 1 , where the diagnostic data set comprises congenital syndromes.5. The system of claim 1 , where the diagnostic data set comprises developmental and exposure related syndromes.6. The system of claim 1 , where the diagnostic data set comprises veterinary breed characteristics.7. The system of claim 1 , further ...

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27-06-2013 дата публикации

Method for displaying the temperature field of a biological subject

Номер: US20130165797A1

Measurements for medical diagnostic purposes measure the temperature of parts of the body to diagnose illnesses and for monitoring dynamics of an illness during treatment. This increases accuracy and clarity and simplifies technical implementation. An image of the region of the body of a biological subject under investigation is input into a computer database, with the image being output to a monitor of the computer, wherein the measurement points for measuring the temperature in the region of the subject under investigation are displayed in the image of the subject on the monitor screen and, once the measurements have been taken and the results of the measurements have been processed in the computer, an image of the temperature field is generated by a computer.

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04-07-2013 дата публикации

DIAGNOSTIC IMAGING APPARATUS AND METHOD OF OPERATING THE SAME

Номер: US20130169782A1
Принадлежит: SAMSUNG MEDISON CO., LTD.

A diagnostic imaging apparatus and a method of operating the diagnostic imaging apparatus. The diagnostic imaging apparatus includes: a probe that scans a subject, into which a contrast agent is injected, to obtain a scan signal; and a display unit that displays a scan video image obtained based on the scan signal, on a first region of a screen, and N captured images from the scan video image on a second region of the screen, where N is a natural number. 1. A diagnostic imaging apparatus , comprising:a probe that scans a subject into which a contrast agent is injected, to obtain a scan signal; anda display unit that displays a scan video image obtained based on the scan signal, on a first region of a screen, and N captured images from the scan video image on a second region of the screen, where N is a natural number.2. The diagnostic imaging apparatus of claim 1 , wherein the display unit displays a reference time-intensity curve which is a time-intensity curve of a region of interest (ROI) in the scan video image claim 1 , on the first region.3. The diagnostic imaging apparatus of claim 2 , wherein the display unit displays N marker time-intensity curves respectively corresponding to the N captured images on the second region claim 2 , and each of the N marker time-intensity curves indicates capture time point or capture time section of a corresponding captured image among the N captured images based on the reference time-intensity curve.4. The diagnostic imaging apparatus of claim 2 , wherein the N captured images are obtained based on a user request.5. The diagnostic imaging apparatus of claim 2 , further comprising a control unit that divides the scan video image into N phases based on the reference time-intensity curve claim 2 , and captures the scan video image from each of the N phases to obtain the N captured images.6. The diagnostic imaging apparatus of claim 2 , wherein the ROI is obtained based on a user request.7. The diagnostic imaging apparatus of ...

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04-07-2013 дата публикации

OPTICAL COHERENT IMAGING MEDICAL DEVICE

Номер: US20130172735A1
Принадлежит: AIMAGO S.A.

The invention concerns an OCI medical device () comprising the following elements:—a coherent light source (),—a 2D light sensor (),—a screen () that displays OCI map and/or mixture map,—a processing unit that calculates the OCI map; all said elements being included in a single movable unit. The invention also relates to the use of said OCI medical device. 2. An OCI medical device according to wherein said unit comprises an upper face and a bottom face claim 1 , said screen being located on said upper face and said 2D light sensor and/or its aperture being located on said bottom face.3. An OCI medical device according to wherein said unit comprises a front face and a bottom face claim 1 , said screen being located on said front face and said 2D light sensor and/or its aperture being located on said bottom face.4. An OCI medical device according to wherein said unit comprises a rotatable panel and a bottom face claim 1 , said screen being located on said rotatable panel and said 2D light sensor and/or its aperture being located on said bottom face.5. An OCI medical device according to comprising two collimated coherent light sources which are oriented in a manner as to focus their respective beams on a same point.6. An OCI medical device according to comprising real-time OCI means which are adapted to show on said screen a real-time OCI of an observed area.7. An OCI medical device according to comprising real-time color or black-and-white visualization means which are adapted to show on said screen a real time regular view of an observed area.8. An OCI medical device according to showing a mixture map wherein the transparency of the OCI map is either a uniform fixed claim 6 , a user-set uniform value or calculated depending on the value and/or the confidence level of the OCI map claim 6 , optionally with some user-configurable level.9. An OCI medical device according to that allows the user interface to be turned or swapped while keeping the said real-time OCI means ...

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04-07-2013 дата публикации

ANALYSIS APPARATUS AND ANALYSIS METHOD

Номер: US20130172741A1
Принадлежит:

An analysis apparatus which analyses a state of a specimen and includes: a temperature adjustment unit which lowers a temperature of the specimen by cooling the specimen; a light source which heats at least a part of the specimen cooled by the temperature adjustment unit, by illuminating the specimen with light; a first temperature measurement unit which measures a temperature change of the specimen caused by the heating by the light source; and an analysis unit which analyzes the state of the specimen based on the temperature change of the specimen. For example, the first temperature measurement unit has an ultrasonic probe which transmits an ultrasonic pulse to the specimen and receives a reflected wave that is the ultrasonic pulse reflected from the specimen, and measures the temperature of the specimen based on a signal of the reflected wave. 1. An analysis apparatus which analyzes a state of a specimen , the apparatus comprising:a temperature adjustment unit configured to lower a temperature of the specimen by cooling the specimen;a light source which heats at least a part of the specimen cooled by the temperature adjustment unit, by illuminating the specimen with light;a first temperature measurement unit configured to measure a change in the temperature of the specimen caused by the heating by the light source; andan analysis unit configured to analyze the state of the specimen based on the temperature change of the specimen.2. The analysis apparatus according to claim 1 ,wherein the first temperature measurement unit includes:an ultrasonic probe which transmits an ultrasonic pulse to the specimen and receives a reflected wave that is the ultrasonic pulse reflected from the specimen; andan ultrasonic wave analysis unit configured to measure the temperature of the specimen based on a signal of the reflected wave received by the ultrasonic probe,the analysis apparatus further comprisesa storage unit configured to store, into a memory unit, the signal of the ...

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