15-08-2013 дата публикации
Номер: US20130211215A1
Принадлежит:
PHOTOCURE ASA
Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer. 1. A hyperosmotic preparation comprising a photosensitizing agent and at least one hyperosmotic agent , wherein the photosensitizing agent comprises 5-ALA , a precursor or a derivative thereof.2. The hyperosmotic preparation of which comprises at least one hyperosmotic agent selected from the group consisting of salts claim 1 , sugars claim 1 , sugar alcohols claim 1 , glycerol claim 1 , polyols and combinations thereof.3. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises magnesium sulphate claim 2 , magnesium hydroxide claim 2 , magnesium citrate claim 2 , magnesium chloride claim 2 , sodium phosphate claim 2 , or any combination thereof.4. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises sorbitol claim 2 , mannitol claim 2 , lactitol claim 2 , xylitol claim 2 , lactulose claim 2 , fructose claim 2 , galactose claim 2 , lactose claim 2 , or any combination thereof.5. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises a polyether polyol claim 2 , preferably a polyethylene glycol (PEG) or polyethylenepolypropylene glycol (PPG).6. The hyperosmotic preparation of claim 1 , wherein the photosensitizing agent comprises a 5-ALA derivative or a pharmaceutically acceptable salt thereof.7. The hyperosmotic preparation of claim 1 , wherein the photosensitizing agent is a compound of formula I or ...
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