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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 15341. Отображено 100.
12-01-2012 дата публикации

Systems, Methods and Computer-Accessible Medium Which Provide Microscopic Images of at Least One Anatomical Structure at a Particular Resolution

Номер: US20120008146A1
Принадлежит: General Hospital Corp

Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

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26-01-2012 дата публикации

Methods and apparatus for assesment and treatment of body cavities

Номер: US20120022380A1
Автор: Ary S. Chernomorsky
Принадлежит: Transmed7 LLC

Methods and apparatus for detection, assessment and optionally treatment of the cancerous tissue in the natural and manmade body cavities. An expandable cavity assessment device that is coupled with cancer detecting elements is placed in a cavity in close proximity to the site of cancerous tissue. The cavity assessment device may receive an optical fiber, or other type of energy conduit and potentially a radioactive source for interstitial radiation therapy. The cavity assessment device may be equipped with a balloon member coupled with electro conductive elements. Further, a system facilitating substance communication with the internal surface of the cavity is provided.

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01-03-2012 дата публикации

Image acquisition and display method and image capturing and display apparatus

Номер: US20120050514A1
Принадлежит: Fujifilm Corp

Identifying, based on a special image, a prescribed region of interest in a special image, determining a boundary line of an area which includes a region in an ordinary image corresponding to the identified region of interest and a predetermined margin added to the region, and displaying a boundary line of the region and the boundary line of the area in the ordinary image.

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08-03-2012 дата публикации

Re-calibration of pre-recorded images during interventions using a needle device

Номер: US20120059251A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.

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15-03-2012 дата публикации

Method of data acquisition for three-dimensional imaging

Номер: US20120062701A1
Принадлежит: Dimensional Photonics International Inc

Described are embodiments of methods of obtaining three-dimensional (3D) surface data of an object scene such as an intra-oral cavity. For example, measured surfaces may include the enamel surface of teeth, the dentin substructure of teeth, gum tissue and various dental structures. The methods can also be applied in medical applications and other applications in which 3D measurement data are acquired with maneuverable 3D measurement devices. In certain embodiments, the measurement device is positioned and translated to enable 3D data to be acquired for a backbone 3D data set. Subsequent controlled motion of the measurement device enables additional 3D data to be acquired and accurately joined to the backbone 3D data set.

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15-03-2012 дата публикации

Catheter with imaging assembly

Номер: US20120065469A1
Принадлежит: TYCO HEALTHCARE GROUP LP

A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal.

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29-03-2012 дата публикации

Systems and methods for analysis and treatment of a body lumen

Номер: US20120078121A1
Принадлежит: Cornova Inc

A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.

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29-03-2012 дата публикации

Medical apparatus system having optical fiber load sensing capability

Номер: US20120078138A1
Принадлежит: Endosense SARL

Apparatus is provided for diagnosing or treating an organ or vessel, wherein a device having at least two optical fiber sensors disposed in a distal extremity thereof is coupled to processing logic programmed to compute a multi-dimensional force vector responsive to detected changes in the optical characteristics of the optical fiber sensors arising from deflection of the distal extremity resulting from contact with the tissue of the wall of the organ or vessel. The force vector may be used to facilitate manipulation of the catheter either directly or automatically using a robotic system.

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10-05-2012 дата публикации

Optical probe with feedback correction

Номер: US20120113491A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The present invention relates to an optical probe ( 1 ) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system ( 9, 10 ) comprising drive coils ( 9 ) capable of displacing the distal end ( 3 ) of an optical guide ( 2 ) housed ( 4 ) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

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10-05-2012 дата публикации

Light-based, transcutaneous video signal transmission

Номер: US20120116155A1
Автор: Robert M. Trusty
Принадлежит: Ethicon Endo Surgery Inc

A surgical device is disclosed which includes an optical source for wirelessly transmitting a light based signal transcutaneously and a receiver for receiving the light based signals. The wireless coupling of signals between the optical source and the receiver wirelessly transmits video images from an internal site in a patient to a video monitor or other viewer outside the patient, and may wirelessly transmit control signals from a controller outside of the patient to an instrument inside the patient during a therapeutic or diagnostic surgical procedure.

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10-05-2012 дата публикации

Imaging guidewire

Номер: US20120116205A1
Автор: Arieh Sher
Принадлежит: ArioMedica Ltd

An imaging guidewire having at its distal tip at least a first Imaging sensor of a forward looking imaging system directed towards an area to be treated and configured to provide imaging data to a processing system, an optical imaging system directed towards an area that has already been treated and configured to provide imaging data of a treated area to the image processing system and at least one display device for displaying images processed by the image processing system. Operating the imaging guidewire during a medical procedure includes the steps of: Generating an image of an area to be treated; Upon completion of at least a portion of the medical treatment, generating an image of an area that has been treated; and displaying at least the first and second images; wherein each one of the first and second images can be generated by one or more imaging modalities.

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24-05-2012 дата публикации

Detection and treatment of autoimmune disorders

Номер: US20120130350A1
Принадлежит: Seattle Childrens Hospital

Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.

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31-05-2012 дата публикации

Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract

Номер: US20120136209A1

Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities.

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05-07-2012 дата публикации

Assembly with Imaging Electronics

Номер: US20120172665A1
Принадлежит: TYCO HEALTHCARE GROUP LP

A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal.

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12-07-2012 дата публикации

Tube for inspecting internal organs of a body

Номер: US20120179009A1
Автор: Oren Gavriely
Принадлежит: Individual

An inspection tube ( 20 ) for use in the medical practice, in which sensors, such as a miniature electronic camera, are incorporated in the distal face of the tube. The sensors receive energy supplied via conduits ( 24, 26, 28 ) running along the length of the tube, preferably embedded within the wall. Signals of the sensors are transmitted to the rear of the tube where they are fed into receivers. Sensor cleaning can be affected in some embodiments by conducting cleaning agents through a channel in the wall of the tube. An alarm procedure can be affected by comparing sensed pattern with a reference base pattern and defining a critical deviation from the reference base .

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26-07-2012 дата публикации

System and method for endoluminal and translumenal therapy

Номер: US20120191079A1
Принадлежит: Hansen Medical Inc

A system for conducting a denervation of the neural plexus adjacent the renal artery of a patient comprises a first elongate member operatively coupled to a testing element, a second elongate member having a distal portion coupled to an ablative element, and a controller configured to: activate an ablative element to selectively denervate a portion of the neural plexus which is positioned adjacent the ablative element; monitor a level of a compound in blood sampled from the testing element of the first elongate member; and modulate the activation of the ablative element based at least in part upon the level of renin monitored using the testing element.

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09-08-2012 дата публикации

Transceiver unit in a measurement system

Номер: US20120203118A1
Принадлежит: St Jude Medical Systems Ab

A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the sensor wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

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13-09-2012 дата публикации

Bodily fluid composition analyzer with disposable cassette

Номер: US20120232362A1
Принадлежит: Optiscan Biomedical Corp

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

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13-09-2012 дата публикации

Method and Apparatus for Cervical Cancer Screening

Номер: US20120232408A1
Принадлежит: Individual

The present invention relates to an apparatus for cervical cancer screening, comprising one or more light sources aligned with a beginning of a first optical test path and a beginning of a second optical test path, one or more optical detectors aligned with an end of the first optical test path and an end of the second optical test path, and a processor coupled to the one or more light sources and the one or more optical detectors and methods for using the same. The present invention further relates to a method for cervical cancer screening.

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20-09-2012 дата публикации

Oral optical diagnosing apparatus and operating method thereof

Номер: US20120238881A1
Принадлежит: Crystalvue Medical Corp

An oral optical diagnosing apparatus and operating method are disclosed. The oral optical diagnosing apparatus includes a positioning module, an optical sensing module, a processing module, and a display module. After the positioning module selects a region to be diagnosed in a mouth, the optical sensing module will perform optical sensing on the region to be diagnosed to obtain optical information related to the region to be diagnosed. The processing module is used to analyze the optical information to generate an optical diagnosed result. The display module is used to display the optical diagnosed result.

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20-09-2012 дата публикации

Methods of evaluating normalcy of lips and safety of lip treatments

Номер: US20120238913A1
Принадлежит: Medicis Pharmaceutical Corp

This disclosure relates to evaluating and objectively determining the relative normalcy of a human patient's lips, whether before or after a lip treatment, or independent from any lip treatment. The normalcy of a patient's lips is evaluated by examining a number of indicia and comparing the results to corresponding lip scales or reference descriptions. The normalcy may be evaluated before and after a lip treatment to determine the safety of the lip treatment.

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20-09-2012 дата публикации

Apparatus and method for treating obstructive sleep apnea

Номер: US20120239111A1
Автор: Douglas B. Mccreery
Принадлежит: Huntington Medical Research Institute

The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.

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25-10-2012 дата публикации

Catheter

Номер: US20120271174A1
Автор: Shigenobu Iwahashi
Принадлежит: Terumo Corp

A catheter includes a catheter main body provided with a window portion through which an inspection wave passes, a drive shaft provided with a detection unit detecting the inspection wave and concurrently installed advanceably and retractably in an axial direction inside the catheter main body, and a bias member biasing a force onto the drive shaft for moving the drive shaft forward toward the distal side thereof.

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08-11-2012 дата публикации

Systems and methods for endoscopic angle-resolved low coherence interferometry

Номер: US20120281224A1
Автор: Adam Wax, John W. Pyhtila
Принадлежит: Duke University

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

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15-11-2012 дата публикации

Vessel pulse wave measurement system conducting vessel pulse wave measurement by obtaining pulsation waveform of blood vessel

Номер: US20120289839A1
Принадлежит: ACT Medical Service Co Ltd

A vessel pulse wave measurement system performs vessel pulse wave measurement using an optical probe circuit provided with an optical probe including a light emitting element and a light receiving element, a drive circuit, and a detection circuit. A measurement device directly and synchronously feeds back an electrical signal from the optical probe to the drive circuit as a drive signal to generate a self-oscillation signal from the detection circuit, and measures the self-oscillation signal as a vessel pulse wave signal. A controller controls an operating point of at least one of the detection circuit and the drive circuit such that the self-oscillation signal substantially reaches a maximum level thereof.

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29-11-2012 дата публикации

Optical sensor and method for detecting a patient condition

Номер: US20120303081A1
Автор: William T. Donofrio
Принадлежит: MEDTRONIC INC

An implantable medical device for monitoring tissue perfusion that includes a light source emitting a light signal and a light detector receiving emitted light scattered by a volume of body tissue. The light detector emits a signal having an alternating current component corresponding to the pulsatility of blood flow in the body tissue volume. A processor receives the current signal and determines a patient condition in response to the alternating component of the current signal.

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03-01-2013 дата публикации

System and method for sub-surface fluorescence imaging

Номер: US20130006116A1
Принадлежит: UNIVERSITY HEALTH NETWORK

Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

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24-01-2013 дата публикации

Distributed Medical Sensing System and Method

Номер: US20130023763A1
Принадлежит: Volcano Corp

A distributed medical sensing system including a first hub configured to receive first medical characteristic data from a first body sensing device, the first body sensing device being located in a first sterile field and a second hub configured to receive second medical characteristic data from a second body sensing device, the second body sensing device being located in a second sterile field spaced from the first sterile field. The system also includes a computing device outside of the first and second sterile fields and communicatively coupled to the first and second hubs, the computing device configured to receive the first and second medical characteristic data from the respective first and second hubs, process the first and second medical characteristic data, and transmit the processed first and second medical characteristic data to the respective first and second hubs.

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07-02-2013 дата публикации

Adaptive illumination method and apparatus for dental shade matching

Номер: US20130034823A1
Принадлежит: Individual

An intra-oral imaging apparatus for obtaining an image of a tooth has an image capture apparatus with an imaging sensor that is energizable to obtain image data and one or more optical elements for directing light from the tooth to the imaging sensor. An illumination apparatus has one or more light sources energizable to emit light and a spatial light modulator that is configurable to shape an illumination beam from the emitted light. One or more optical elements relay the shaped illumination beam toward the tooth surface. A control logic processor in signal communication with the imaging sensor obtains image data and in signal communication with the spatial light modulator shapes the illumination beam according to the obtained image data.

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21-02-2013 дата публикации

Systematic distillation of status data relating to regimen compliance

Номер: US20130043975A1
Принадлежит: ELWHA LLC

Configuration technologies for cost-effectively monitoring indicia of regimen compliance or noncompliance in response to one or more indications of symptoms or actions or other data on data-bearing media or in wireless transmissions, such as implementing techniques for providing or preventing access or otherwise acting on or communicating incremental or definitive indicia of compliance or noncompliance.

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21-02-2013 дата публикации

Method of analyzing and processing signals

Номер: US20130046157A1
Принадлежит: Nellcor Puritan Bennett Ireland ULC

A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.

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21-02-2013 дата публикации

Method of analyzing and processing signals

Номер: US20130046184A1
Принадлежит: Nellcor Puritan Bennett Ireland ULC

A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.

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21-02-2013 дата публикации

Method of analyzing and processing signals

Номер: US20130046187A1
Принадлежит: Nellcor Puritan Bennett Ireland ULC

A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.

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28-02-2013 дата публикации

Detection of lipid core plaque cap thickness

Номер: US20130053698A1
Принадлежит: Infraredx Inc

Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed.

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07-03-2013 дата публикации

Method and apparatus for examining inner ear

Номер: US20130060131A1

An apparatus, for examining an inner ear is provided. An endoscope is provided, comprising a wave guide and an end piece comprising an end window to be placed a first distance from an inner ear, wherein the waveguide focuses light to create a focal plane the first distance from the end window. An optical coherence tomography (OCT) system is connected to a second end of the wave guide and comprises an imaging system connected to the OCT system for generating an image of the inner ear.

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21-03-2013 дата публикации

SKIN OPTICAL CHARACTERIZATION DEVICE

Номер: US20130072803A1
Принадлежит: PALOMAR MEDICAL TECHNOLOGIES, INC.

The present invention is generally directed to dermatological devices and methods in which one or more skin characteristics, such as the melanin index, are determined by analyzing radiation backscattered from a skin region illuminated by at least one, and preferably, two or more wavelengths, e.g., in a range of about 600 nm to about 900 nm. In many embodiments, the radiation is coupled to the skin via a waveguide, and an optical sensor is employed to ascertain contact between the waveguide (e.g., a waveguide surface adapted for contact with the skin) and the skin. 145-. (canceled)46. A dermatological device , comprisingat least one radiation source,a waveguide optically coupled to the radiation source to transmit radiation from the source to the skin, said waveguide having two opposed surfaces and a sidewall extending between said surfaces,a detector coupled to the waveguide to detect at least a portion of radiation backscattered from a skin region illuminated by the source radiation, and an optical contact sensor optically coupled to said sidewall, said sensor determining whether said waveguide is in contact with the skin based on detection of backscattered radiation leaking through said sidewall.47. A dermatological device , comprising:a radiation source assembly;a first waveguide having a proximal end adapted to receive radiation from the radiation source assembly and a distal end adapted to transmit radiation to a tissue;a second waveguide having a distal end adapted to receive backscattered radiation from said first waveguide and a proximal end adapted to transmit said backscattered radiation;a detector optically coupled to said second waveguide and configured to measure a physical characteristic of said tissue; anda processor electrically coupled to the detector and configured to receive a signal from said detector corresponding to said backscattered radiation;wherein said processor is configured to determine a physical characteristic of said tissue based on ...

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21-03-2013 дата публикации

LIGHT TRANSMITTING PROBE, LIGHT RECEIVING PROBE, LIGHT TRANSMITTING AND RECEIVING PROBE, AND LIGHT MEASUREMENT DEVICE USING SAME

Номер: US20130072804A1
Автор: Inoue Yoshihiro
Принадлежит: SHIMADZU CORPORATION

A light transmitting probe comprising: a housing for fixing the probe to a mounting portion of a holder to be mounted on a subject; a light emitter for emitting light, the light emitter being placed in an end portion of the housing; and a transmission channel, one end of which is connected to the light emitter, and the other end of each is connected to a controller; the light transmitting probe irradiating the subject with light when fixed to the holder, and being characterized in that the end portion of the housing has a number of rod-shaped protrusions, the light emitter is a number of light emitting elements, the light emitting elements are respectively placed in an end portion of each protrusion, the transmission channel is a number of transmission channels, and the transmission channels are respectively placed inside each protrusion. 1. A light transmitting probe , comprising:a housing for fixing the probe to a mounting portion of a holder to be mounted on a subject;a light emitter for emitting light placed in an end portion of said housing; anda transmission channel, one end of which is connected to the light emitter and the other of which is connected to a controller,the light transmitting probe irradiating the subject with light when fixed to said holder and being characterized in thatthe end portion of said housing has a number of rod-shaped protrusions,said light emitter is a number of light emitting elements which are respectively placed in an end portion of each protrusion, andsaid transmission channel is a number of transmission channels which are respectively placed inside each protrusion.2. A light receiving probe , comprising:a housing for fixing the probe to a mounting portion of a holder to be mounted on a subject;a light receiver for detecting light placed in an end portion of said housing; anda transmission channel, one end of which is connected to the light receiver and the other of which is connected to a controller,the light receiving probe ...

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28-03-2013 дата публикации

METHOD TO MEASURE SKIN ELASTICITY AND FIRMNESS

Номер: US20130079643A1
Принадлежит: LVMH RECHERCHE

The invention relates to a method of measuring the elasticity and firmness of skin. The invention also relates to methods of measuring improvements in a person's skin health by measuring firmness and elasticity before, during and after a cosmetic treatment. The invention further relates to methods of measuring the improvement in a person's skin firmness and elasticity that a cosmetic agent may cause when applied on the skin. 1. A method of determining a skin elasticity value for the skin of a person , said method using infrared thermography imaging coupled with a mechanical deformation system comprising at least two metallic plates intended to pinch a skin sample of the person.2. The method of claim 1 , wherein the method comprises the steps ofa—contacting the metallic plates of the mechanical deformation system with the skin sample and recording a first thermal image of the skin on which thermal prints of the metallic plates on skin can be displayed,b—pinching the skin sample with the mechanical deformation system intended to trap said skin sample, and subsequently releasing the system,c—recording a second thermal image of the skin on which thermal prints of the metallic plates on skin can be displayed,d—calculating a value associated with an elastic recovery of the skin sample.3. The method of claim 1 , wherein in step b claim 1 , the pinching of the skin is made under a controlled pressure being between 20 and 40 N.4. The method of claim 1 , wherein the metallic plates are parallel.5. The method of claim 2 , the value associated with an elastic recovery of the skin sample corresponds to the ratio between a first distance corresponding to the distance between the thermal prints of the metallic plates after pinching measured in step c claim 2 , and a second distance corresponding to the distance between the thermal prints of the metallic plates before pinching measured in step a.6. The method of claim 5 , wherein the skin is considered as having high elasticity and ...

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04-04-2013 дата публикации

BRAIN-MACHINE INTERFACE BASED ON PHOTONIC NEURAL PROBE ARRAYS

Номер: US20130085398A1
Автор: Roukes Michael L.
Принадлежит: California Institute of Technology

Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue. In another version, the method includes detecting photons from a volume of a tissue using a three-dimensional array of optical detectors inserted into the tissue. A probe device for illuminating tissue and/or detecting photons emitted from tissue includes elongated microsized probes containing optical emitters and optical detectors in a three dimensional array. 1. A method for examining a tissue , comprisingilluminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue.2. The method of claim 1 , wherein the tissue is a neural tissue.3. The method of claim 2 , wherein the neural tissue is prepared by optogenetic methods.4. The method of claim 1 , wherein the array comprises elongated microsized probes comprising the optical emitters.5. The method of claim 1 , wherein the optical resolution of the array is about 200 μm in at least one dimension of the volume.6. The method of claim 1 , wherein the photons are produced from a source that comprises an emission multiplexer.7. A method for examining a tissue claim 1 , comprisingdetecting photons from a volume of a tissue using a three-dimensional array of optical detectors inserted into the tissue.8. The method of claim 7 , wherein the tissue is a neural tissue.9. The method of claim 7 , wherein the array comprises elongated microsized probes comprising the optical detectors.10. The method of claim 7 , wherein the photons are produced by illuminating the tissue volume.11. The method of claim 7 , wherein the optical resolution of the array is about 200 μm in at least one dimension of the volume.12. The method of claim 7 , wherein the photons are produced by illuminating the tissue volume using a three-dimensional array of optical emitters ...

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18-04-2013 дата публикации

Oral scope system with image sensor and method for visual examination of oral cavity and upper airway

Номер: US20130096457A1
Автор: Chunyuan Qiu, Zaiqi Wang
Принадлежит: Qscope LLC

An oral scope instrument for facilitating visual examination and inspection of a person's oral cavity and upper airway includes an elongate, flexible arm having first and second ends, a temperature sensor connected to the flexible arm adjacent the first end, an image sensor mounted adjacent the second end, a processor in electrical communication with the image sensor and an image display device. An illumination unit located adjacent the second end provides illumination for the image sensor. A handle connected to the first end enables manual insertion of the flexible arm into the mouth along a portion of the top of the tongue to engage the temperature sensor therewith and position the image sensor for viewing and recording anatomical features of the oral cavity or the upper airway. The processor stores normal anatomical images and may transmit images of recorded anatomical features to the image display device.

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25-04-2013 дата публикации

Chalcogenide-fibre, infrared evanescent wave sensor and process for producing same

Номер: US20130102066A1

The invention relates to a fibre sensor that enables the propagation of infrared light at at least one wavelength of 0.8 to 25 micrometres, the fibre successively comprising along its length a first infrared waveguide section ( 23 ), a second detection section ( 25 ) intended to come into contact with an external environment in order to detect infrared signatures interfering with the propagation of the evanescent waves propagating along the fibre ( 2 ), and a third infrared waveguide section ( 27 ). The invention is characterized in that, in the second fibre section ( 25 ) that has the detection role, the fibre ( 2 ) is constituted of a curved part, the radios of curvature of which is locally less than 2.3 millimetres.

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25-04-2013 дата публикации

Medical image registration using a rigid inner body surface

Номер: US20130102893A1
Принадлежит: BRAINLAB AG

The invention relates to a medical image registration method in which an actual patient's body or portion of a patient's body ( 22 ) is positionally registered to a patient image created using a medical body-imaging technique such as MR, CT or x-ray imaging, wherein in a medical navigation system, the actual spatial position of at least a part of the body or body portion ( 22 ) is assigned to a respective position in the image of said body or body portion ( 22 ), wherein the part of the body or body portion ( 22 ) comprises a registration area in the form of the surface of a substantially rigid body structure, in particular an inner structure, made of bone or cartilage. The invention also relates to a medical image registration device which comprises a surface scanner ( 15 ) for scanning a registration area comprising the surface of a substantially rigid body structure, in particular an inner structure, made of bone or cartilage.

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25-04-2013 дата публикации

Micro Vein Enhancer

Номер: US20130102905A1

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

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02-05-2013 дата публикации

Device for taking three-dimensional and temporal optical imprints in color

Номер: US20130108981A1
Автор: Francois Duret
Принадлежит: Individual

Device for taking three-dimensional and temporal optical imprints in color, including a three-dimensional dental imaging device that does not employ structured light projection. The device includes a stereo camera having at least two CCD or CMOS color sensors in preset positions, an optical system of fixed and preset focal length, an LED lighting system, and an electronic system located behind or near the sensor, controlling the latter but also the LEDs illuminating the imprint capture region. The system includes a central processing unit and a card for controlling said LEDs. The sensors are distributed over all or part of a dental arch, being placed in a sort of optical impression tray allowing a complete image of the arch to be captured in a single exposure.

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02-05-2013 дата публикации

SYSTEMS AND METHODS FOR PULMONARY MONITORING AND TREATMENT

Номер: US20130109932A1
Принадлежит: Sonitus Medical, Inc.

Systems and methods are disclosed determining a pulmonary function by mounting one or more sensors intra-orally; capturing intra-oral data; and determining the pulmonary function based on an analysis of the intra-oral data. 1. A method for determining a pulmonary function of a patient , comprising:a. mounting one or more sensors intra-orally upon at least one tooth via an intra-oral appliance, wherein the appliance produces an interference fit between the appliance and at least two surfaces of at least one tooth;b. capturing intra-oral data via the one or more sensors; andc. determining the pulmonary function based on an analysis of the intra-oral data.2. The method of claim 1 , further comprising determining an intermittent breathing condition from an intra-oral sound captured by the one or more sensors or determining a snoring condition from the intra-oral sound.3. The method of claim 1 , wherein mounting further comprises providing the appliance having an actuatable transducer disposed Within or upon a housing of the appliance.4. The method of claim 3 , wherein after determining the pulmonary function claim 3 , maintaining contact between a surface of the at least one tooth and the actuatable transducer such that the transducer transmits vibrations to a surface of the at least one tooth.5. The method of claim 1 , wherein capturing comprises:a. measuring a magnitude and a frequency of an intra-oral sound; andb. determining one or more intervals between breaths from the intra-oral sound.6. The method of claim 1 , wherein capturing comprises measuring oxygen concentration or carbon dioxide saturation.7. The method of claim 1 , wherein capturing comprises measuring oxygen data through a lax stratum corneum or a dermal structure.8. The method of claim 1 , wherein capturing comprises performing claim 1 , a dual-color ratiometric oxygen saturation measurement.9. The method of claim 1 , wherein capturing comprises measuring breath oxygen or carbon dioxide content.10. The ...

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02-05-2013 дата публикации

NON-CONTACT AND PASSIVE MEASUREMENT OF ARTERIAL PULSE THROUGH THERMAL IR IMAGING, AND ANALYSIS OF THERMAL IR IMAGERY

Номер: US20130109976A1

A non-contact, passive method for measurement of arterial pulse from areas such as the major superficial arteries of the body through analysis of thermal IR images acquired by passive thermal IR imaging sensors, and through the modeling of the pulsatile nature of the blood flow and arterial pulse propagation in the circulatory system. The method is automatic and does not need operator input. The output waveform readily contains the information on heart rate, cardiac interbeat intervals, heart-rate variability and other features inherent in arterial pulse. The potential applications of this method, device and system are in the fields of non-contact and passive measuring cardiovascular and autonomic regulatory functions, mental and emotional loads, assessment of health in general, prediction of ill physiological and mental conditions, smart rooms, human-computer interaction, polygraph testing, intent identification, and any other fields where non-contact, passive monitoring of heart-rate and its variability is needed. 1. A system for obtaining an arterial pulse waveform comprising:a non-contact and passive thermal radiation imaging sensor configured and arranged to obtain a sequence of thermal infrared images of a subject containing one or more regions of interest;means for thermal infrared data translation, storing, processing and retrieving of the obtained sequence of thermal infrared images;means for detecting at least one region of interest in the obtained sequence of thermal infrared imagesmeans for tracking said at least one region of interest in the obtained sequence of thermal IR imagesmeans for identification of one or more of faithful configurations of region of measurement using pulsatile nature of arterial pulse phenomena; andmeans for determining the arterial pulse by analyzing the faithful configuration or region of measurement.2. The system according to claim 1 , wherein said thermal infrared images comprise electromagnetic wavelengths between ...

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09-05-2013 дата публикации

RENAL FUNCTION ANALYSIS METHOD AND APPARATUS

Номер: US20130116518A1

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule. 130-. (canceled)31. An apparatus for analyzing the condition of a kidney , said apparatus comprising:a source of a kidney function analysis composition, said composition comprising a plurality of fluorescent reporter molecules and a plurality of fluorescent marker molecules, said reporter molecules and said marker molecules sharing a molecular property;a catheter for introducing the analysis composition into the blood steam of a patient; anda detector for monitoring the level of the analysis composition within the blood stream and reporting the operating condition of the kidney;wherein the volume of plasma distribution based on the fluorescent of the marker molecules relative to the fluorescence of the reporter molecules is calculated and reported as a measure of kidney function and condition.32. The apparatus of wherein the molecular property is selected from the group consisting of molecular weight claim 31 , size claim 31 , shape claim 31 , charge claim 31 , fluorescence and radio frequency.33. The apparatus of wherein the molecular property is fluorescence claim 32 , the reporter molecule has a first fluorescence claim 32 , and the marker molecule has a second fluorescence.34. The apparatus of wherein the molecular property is molecular weight claim 32 , the reporter molecule has a first molecular weight claim 32 , and the marker molecule has a second molecular weight which is greater than the molecular weight of ...

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09-05-2013 дата публикации

Biological measuring apparatus and biological measuring method

Номер: US20130116553A1
Принадлежит: Canon Inc

A biological measuring apparatus measures physical parameters in a part of a living body by diffuse optical tomography. The apparatus includes at least one first light source and one first detector both disposed inside the living body, at least one second light source and one second detector both disposed outside the living body. A processor processes measured values and reconstructs the distribution of scattering coefficients or absorption coefficients of light interacting with the living body. The measured values are acquired from at least one measurement light beam emitted from the first light source and detected by one of the first and second detectors, and at least one measurement light beam emitted from the second light source and detected by one of the first and second detectors.

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16-05-2013 дата публикации

OCCLUSION-CROSSING DEVICES, ATHERECTOMY DEVICES, AND IMAGING

Номер: US20130123615A1
Принадлежит:

Described herein are methods for producing and identifying characteristic (“crescent shaped”) regions indicative of an atherectomy plaque within a vessel, and systems and devices adapted to take advantage of this characteristic region. 1. A method of identifying an atherectomy plaque mass within a vessel , the method comprising:applying circumferential radial force within the vessel to displace a rigid plaque mass and force the vessel wall to stretch away from the device;imaging the vessel to create an image; andidentifying crescent-shaped structures associated with an atherectomy plaque in the image.2. The method of claim 1 , further comprising identifying the orientation of a plaque mass based on the directionality of the crescent-shaped structures.3. The method of claim 1 , further comprising identifying the position of a plaque mass relative to outer layered structures of a vessel wall based on the crescent-shaped structures.4. The method of claim 1 , wherein imaging the vessel comprises imaging the vessel with optical coherence tomography.5. The method of claim 1 , further comprising inserting a device into the vessel claim 1 , the device applying the circumferential radial force.6. The method of claim 5 , wherein imaging the vessel comprises imaging with an imaging sensor attached to the device.7. The method of claim 6 , further comprising orienting the device within the vessel based on the crescent-shaped structures.8. The method of claim 7 , wherein orienting the device comprises pointing a directional cutter at a plaque mass identified based upon the crescent-shaped structure.9. The method of claim 7 , wherein orienting the device comprises directing the device based upon the relationship between markers in the image and the crescent-shaped structures.10. The method of claim 6 , further comprising rotating the imaging sensor to obtain the image.11. An atherectomy device having a distal end configured to dissect plaque from within a vessel claim 6 , the ...

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16-05-2013 дата публикации

Medical Workflow System and Method

Номер: US20130123616A1
Принадлежит: VOLCANO CORPORATION

A method of conducting a medical workflow with a touch-sensitive bedside controller is disclosed. The method includes initiating a medical workflow using a graphical user interface on the bedside controller, positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller, controlling the commencement and termination of a recordation of images captured by the imaging tool using the graphical user interface on the bedside controller, navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller, and performing measurements on the image of interest using the graphical user interface on the bedside controller. 1. A method of conducting a medical workflow with a touch-sensitive bedside controller , the method comprising:initiating a medical workflow using a graphical user interface on the bedside controller;positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller;controlling the initiation and termination of a recordation of images by the imaging tool using the graphical user interface on the bedside controller;navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller; andperforming measurements on the image of interest using the graphical user interface on the bedside controller.2. The method of claim 1 , wherein the initiating includes selecting the medical workflow out of a plurality of medical workflows presented as selectable options within the graphical user interface.3. The method of claim 2 , wherein the plurality of medical workflows includes two or more of an intravascular ultrasound (IVUS) imaging workflow claim 2 , an intravascular photoacoustic (IVPA) imaging workflow claim 2 , an optical coherence tomography (OCT) workflow claim 2 , a forward looking IVUS (FL- ...

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16-05-2013 дата публикации

OPTICAL MEASUREMENT APPARATUS, ENDOSCOPE SYSTEM, AND COMPUTER READABLE STORAGE MEDIUM

Номер: US20130123644A1
Автор: GONO Kazuhiro
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP.

An optical measurement apparatus of the present invention includes a light source unit; an operation unit that performs an operation process on the basis of a result of the measurement performed by a measurement unit to obtain a characteristic value of a living tissue; a validity evaluator that evaluates, on the basis of an operation result of the operation process performed by the operation unit, whether the result of the measurement is valid; an output unit that outputs a result of the evaluation performed by the validity evaluator; an input unit that inputs an instruction to adopt the result of the measurement performed by the measurement unit; and a determination unit that determines, on the basis of the result of the evaluation performed by the validity evaluator and the instruction information from the input unit, whether to adopt the result of the measurement performed by the measurement unit. 1. An optical measurement apparatus for measuring an optical characteristic of a living tissue , the optical measurement apparatus comprising:a light source unit that supplies irradiation light to be emitted to the living tissue;a measurement unit that measures reflection light and/or scattering light from the living tissue;an operation unit that performs an operation process on the basis of a result of the measurement performed by the measurement unit to obtain a characteristic value of the living tissue;a validity evaluator that evaluates, on the basis of an operation result useful for validity evaluation in middle of the operation process performed by the operation unit, whether the result of the measurement performed by the measurement unit is valid;an output unit that outputs at least a result of the evaluation performed by the validity evaluator;an input unit that inputs instruction information containing an instruction to adopt the result of the measurement performed by the measurement unit; anda determination unit that determines, on the basis of the result of ...

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23-05-2013 дата публикации

Mandible position indicator for measuring and replicating occlusion

Номер: US20130130195A1
Автор: Roger A. Evenson
Принадлежит: NorthPointe Holding Co LLC

One embodiments of the present subject matter include a method that includes fixing a top pantograph to a patient via clutches to the top teeth of the patient, fixing a bottom pantograph to a patient via clutches to the bottom teeth of the patient, optically monitoring the bite of the patient by monitoring the relation of the top pantograph to the bottom pantograph during a bite cycle, storing data relating to the actual bite storing patient data including a three-dimensional model including a top teeth model and a bottom teeth model, storing a digital top pantograph model associated with the top pantograph, storing a digital bottom pantograph model associated with the bottom pantograph, digitally pairing the bite data, the top pantograph model and the bottom pantograph model to the patient data, and digitally modeling the bite.

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23-05-2013 дата публикации

Multimodal detection of tissue abnormalities based on raman and background fluorescence spectroscopy

Номер: US20130131488A1
Принадлежит: British Columbia Cancer Agency BCCA

Methods and apparatus for classifying tissue use features of Raman spectra and background fluorescent spectra. The spectra may be acquired in the near-infrared wavelengths. Principal component analysis and linear discriminant analysis of reference spectra may be used to obtain a classification function that accepts features of the Raman and background fluorescence spectra for test tissue and yields an indication as to the likelihood that the test tissue is abnormal. The methods and apparatus may be applied to screening for skin cancers or other diseases.

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30-05-2013 дата публикации

OPTICAL CAPSULE AND SPECTROSCOPIC METHOD FOR TREATING AND DIAGNOSING THE INTESTINAL TRACT

Номер: US20130137993A1
Автор: Imran Mir A.
Принадлежит: ENTRACK, INC.

A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length. 1. A system for diagnosing a gastrointestinal condition comprising:an autonomous capsule sized to pass through the intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule; and a sensor configured to sense light of at least one predetermined wavelength at a first location within the intestinal tract and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength;a processor coupled to the sensor to receive a signal representative of light of the at least one predetermined wavelength sensed by the sensor, wherein the processor is configured to control the light source to emit light, determine at least one condition of: a presence of a substance, an absence of a substance, and a condition of tissue of the intestinal tract based at least in part on the signal representative of light sensed by the sensor;a capsule tracking system configured to track a location of the capsule within the intestinal tract independent of capsule orientation, via an acoustic signal transmitted between the autonomous ...

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06-06-2013 дата публикации

SURGICAL INSTRUMENT CONTROL AND ACTUATION

Номер: US20130144116A1
Принадлежит: INTUITIVE SURGICAL OPERATIONS, INC.

Two or more telemanipulated surgical instruments are inserted through a guide tube. Each instrument has a transmission mechanism that transmits actuating forces from actuators to components of the instrument. The transmission mechanisms are arranged around an extended centerline of the guide tube and are wedge-shaped so that they can be positioned more closely to the extended centerline. 118.-. (canceled)19. A method comprising:sensing, by a control system, if either a surgical instrument or an imaging system is mounted on a telemanipulation actuator assembly, wherein the surgical instrument and the imaging system are interchangeably mountable on the telemanipulation actuator assembly;manipulating, by the control system, the surgical instrument with the telemanipulation actuator assembly in an instrument control mode if the sensing indicates that the surgical instrument is mounted on the telemanipulation actuator assembly; andmanipulating, by the control system, the imaging system with the telemanipulation actuator assembly in a camera control mode if the sensing indicates that the imaging system is mounted on the telemanipulation actuator assembly.20. A method comprising:manipulating a surgical instrument with a telemanipulation actuator assembly in a telemanipulation control system instrument control mode if the surgical instrument is sensed as being mounted on the telemanipulation actuator assembly; andmanipulating an imaging system with the telemanipulation actuator assembly in a telemanipulation control system camera control mode if the imaging system is sensed as being mounted on the telemanipulation actuator assembly;wherein the surgical instrument and the imaging system are each configured to be interchangeably mounted on the telemanipulation actuator assembly.21. A method of :wherein manipulating the surgical instrument comprises changing an orientation of an end effector of the surgical instrument without changing a position of the end effector of the ...

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13-06-2013 дата публикации

Modular Headrest and Multi-Light Apparatus

Номер: US20130150683A1
Автор: Irwin N. Boe
Принадлежит: Individual

A multi-light apparatus ( 10 ) for primary use in dental or medicinal operatory workspaces and for interconnection with a modular operating chair ( 12 ), so as to form the headrest thereof, preferably includes first and second radiation sources ( 36,72 ) and a selection mechanism ( 70 ) for selecting a desired radiation source, a rigidly flexible light pipe ( 16 ) that may be alternatively coupled to each light source ( 36,72 ) and is configured to transmit selected radiation to a patient ( 14 ), a reflective surface ( 78 ) configured to direct the selected radiation to the pipe ( 16 ), a power supply ( 50 ), a cooling fan ( 56 ), and at least one potentiometer ( 66,68 ) for varying the voltage delivered to the sources ( 36,72 ) and fan ( 56 ).

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13-06-2013 дата публикации

METHOD FOR DETECTING HEMATOMA, PORTABLE DETECTION AND DISCRIMINATION DEVICE AND RELATED SYSTEMS AND APPARATUSES

Номер: US20130150726A1
Принадлежит:

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light. The near infrared light is emitted at two distances from a brain of the patient, so the emitted light penetrates to two different depths. Such a method also includes applying a ratiometric analysis to the reflected light to distinguish a border between normal tissue and tissue exhibiting blood accumulation. 1. A method for detecting a hematoma , comprising the step(s) of:emitting near infrared light and directing the emitted light towards tissue of a patient;measuring reflected light corresponding to two depths of penetration;obtaining a ratiometric measure of the reflected light corresponding to the two depths of penetration;determining from the obtained ratiometric measure at least the presence of a blood event, the blood event being representative of a blood-tissue injury.2. The method of claim 1 , further comprising the step(s) of:moving an emitter of the near infrared light and a reflected light detection section for detecting the reflected light along an external surface of the tissue; andperforming said steps of emitting, measuring and determining during said step of moving.3. The method of claim 1 , wherein said ratiometric measure is representative of a ratio of densities representing the reflected light of the two penetration depths.4. The method of claim 3 , wherein said determining includes evaluating the ratiometric measure to distinguish between normal tissue and tissue exhibiting blood accumulation.5. The method of claim 1 , wherein the blood event is at least one of an intracranial arachnoid hemorrhage a subdural hematoma or an epidural hematoma.6. The method of claim 1 , further comprising the step(s) ...

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13-06-2013 дата публикации

MAPPING SYSTEM AND METHOD FOR MEDICAL PROCEDURES

Номер: US20130150732A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

A system and method for mapping interluminal structures includes an elongated flexible instrument (). An optical shape sensing device () is disposed within the flexible instrument and is configured to determine a shape of the flexible instrument relative to a reference. The shape sensing device is configured to collect information based on its configuration to map an interluminal structure during a procedure. An imaging enabled ablation device () is mounted at or near a distal end portion of the flexible instrument. 1. A system for mapping interluminal structures , comprising:{'b': '102', 'an elongated flexible instrument ();'}{'b': 152', '154, 'an optical shape sensing device (, ) disposed within the flexible instrument and configured to determine a shape of the flexible instrument relative to a reference, the shape sensing device configured to collect information based on its configuration to map an interluminal structure during a procedure; and'}{'b': '117', 'an imaging enabled ablation device () mounted at or near a distal end portion of the flexible instrument.'}2152154154. The system as recited in claim 1 , wherein the optical shape sensing device includes an optical fiber () having at least one of Fiber Bragg Gratings (FBGs) () and a Rayleigh scatter interrogation setup () for sensing strain in the fiber.3152154. The system as recited in claim 1 , wherein the optical shape sensing device includes an area of higher sensitivity by including an area with a higher number of optical fibers () having optical strain sensors ().4. The system as recited in claim 1 , wherein the optical shape sensing device includes one of a spiral shape claim 1 , a ring shape and a loop shape.5. The system as recited in claim 1 , wherein the reference includes one of a position on the flexible instrument and an anatomical reference.6102. The system as recited in claim 1 , wherein the flexible instrument () includes one of a catheter and an endoscope.7. A system for mapping ...

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13-06-2013 дата публикации

DEVICE AND METHOD FOR DETECTING AN EMBOLUS MOVING IN A BLOOD VESSEL

Номер: US20130150733A1
Автор: Solomon Sasi
Принадлежит:

The invention provides a device for detecting a moving embolism in a blood vessel. One or more sources of electromagnetic radiation deliver electromagnetic radiation to the blood vessel. First and second optical detectors, positioned at a downstream and an upstream location, respectively, along the flow axis of the blood vessel, detect electromagnetic radiation emitted by the sources at the downstream and upstream locations, after having been reflected from, or transmitted through, the blood vessel. A processor monitors one or more parameters of the electromagnetic radiation detected by the downstream and upstream detectors. An embolus in the blood vessel is detected when a transient change in a monitored parameter is first detected by the downstream detector, and, after a time lag, is then detected by the upstream detector. 121-. (canceled)22. A device for detecting a moving embolism in a first blood vessel comprising: (i) a source of electromagnetic radiation adapted to deliver electromagnetic radiation to the first blood vessel;', '(ii) a first optical detector detecting electromagnetic radiation produced by the source of electromagnetic radiation after the electromagnetic radiation has interacted with blood flowing in the first blood vessel;', '(iii) a second optical detector detecting electromagnetic radiation produced by the source of electromagnetic radiation after the electromagnetic radiation has interacted with blood flowing in the first blood vessel, the source of electromagnetic radiation being positioned between the first and second optical detectors;, '(a) one or more optical assemblies, each optical assembly comprising (i) monitor one or more parameters of the electromagnetic radiation detected by the first optical detector and monitor the one or more parameters of the electromagnetic radiation detected by the second optical detector; and', '(ii) detect a first predetermined or statistically significant transient change in one or more of the monitored ...

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20-06-2013 дата публикации

Concentric Drive Scanning Probe

Номер: US20130158393A1
Принадлежит:

An endoprobe for microsurgical procedures is provided, including a hand-piece having a concentric drive having a proximal coupling and a distal coupling and a cannula assembly coupled to the hand-piece. The cannula assembly may include an outer tube having a longitudinal axis and an inner tube positioned within the outer tube, the distal coupling providing a first rotation to the outer tube about the longitudinal axis and the proximal coupling providing a second rotation to the inner tube within the outer tube. According to embodiments disclosed herein a method for scanning a light beam using a cannula assembly as described above is also provided. 1. An endoprobe for microsurgical procedures , comprising:a hand-piece having a concentric drive comprising a proximal coupling and a distal coupling;a cannula assembly coupled to the hand-piece; an outer tube having a longitudinal axis;', 'an inner tube positioned within the outer tube, the distal coupling providing a first rotation to the outer tube about the longitudinal axis and the proximal coupling providing a second rotation to the inner tube within the outer tube., 'the cannula assembly comprising2. The endoprobe of claim 1 , wherein the hand-piece includes a first motor coupled to the distal coupling to provide the first rotation and a second motor coupled to the proximal coupling to provide the second rotation.3. The endoprobe of claim 2 , further including a controller coupled to the first motor and the second motor claim 2 , wherein the first motor provides a rotation to the inner tube in one direction and the second motor provides a rotation to the outer tube in an opposite direction.4. The endoprobe of claim 1 , wherein the proximal coupling and the distal coupling are controlled independently of each other.5. The endoprobe of claim 1 , wherein the proximal coupling and the distal coupling are concentrically located about a probe longitudinal axis.6. The endoprobe of claim 1 , wherein the cannula assembly ...

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20-06-2013 дата публикации

MEDICAL DEVICE WITH SLOTTED MEMORY METAL TUBE

Номер: US20130158414A1
Принадлежит: EVM SYSTEMS LLC

A series of medical instruments can be made with the use of shape memory tube with a transformation temperature that is above or below ambient temperature. In the first case, the material behaves with the shape memory effect and in the second case the behavior is superelastic. The wall of the tube has been provided with a plurality of slots in specific places, often near or at the distal end of the instrument, and in specific arrangements which allow local variations in diameter, shape, and/or length. These variations can either be caused by the memory effect during temperature change or by superelastic behavior during change of the mechanical influences on the memory metal by the surrounding material. 1. A medical instrument comprising:at least one memory metal tube programmed for memory effect or superelasticity and having in at least one section thereof a plurality of slots such that the slotted section is capable of expansion and contraction, said memory metal tube having an expandable section that is substantially filled by an elastically deformable polymer, which upon expansion in a tubular cavity plugs the cavity; anda delivery tube that surrounds at least the slotted section of the memory metal tube during delivery and which is partially removed from surrounding the slotted section of the memory metal tube by a relative longitudinal movement between the respective tubes.2. The instrument of being a retrieval basket for retrieving particles to be removed from the human body.3. The instrument of being a dilator to enlarge the diameter of collapsed or obstructed ducts claim 1 , veins claim 1 , arteries or other cavities in the human body.4. The instrument of being a reaming tool to cut parts off the wall of a cavity by rotational movement around the longitudinal axis of the instrument.5. The instrument of being an expansion tool that is expandable at a distal end to enlarge a body cavity.6. The instrument of wherein the slots in the memory metal tube extend to ...

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04-07-2013 дата публикации

Determining apparatus and determining method

Номер: US20130172863A1
Принадлежит: KEIO UNIVERSITY, Sony Corp

A photodynamic therapy apparatus as a determining apparatus is the photodynamic therapy apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to determine whether the tip portion of the laser catheter contacts the tissue or not.

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11-07-2013 дата публикации

GUM TISSUE GUIDE, SYSTEMS AND METHODS OF PRODUCING AND UTILIZING THE SAME

Номер: US20130177864A1
Принадлежит:

A method, device and system for modifying the gingival margin of a patient is disclosed. A method includes obtaining an electronic model of the dentition of a patient, determining an incision path along the gingival surface based on the electronic model, generating and fabricating a guide arrangement to assist in cutting the gingival surface of the patient, mounting the guide arrangement to the dentition of the patient, and cutting the gingival surface of the patient with the assistance of the guide arrangement. A guide arrangement includes a mounting portion and a template portion coupled to the mounting portion along the gingival surface of the guide arrangement and positioned to provide a desired incision path. A system includes a three dimensional scanner, a computer system and a fabricating device. 1. A method comprising:obtaining an electronic model of at least part of a dentition of a patient, the dentition including a gingival surface;determining an incision path along the gingival surface using a computing device, based at least partially on the electronic model image;generating an electronic model of a guide arrangement including generating a mounting portion of the guide arrangement that is configured to fit over the dentition of the patient and generating a template portion of the guide arrangement that extends from the mounting portion towards the gingival surface of the patient, the template portion defining a guide edge along the incision path; andfabricating the guide arrangement based on the electronic model of the guide arrangement.2. The method of claim 1 , further comprising:mounting the guide arrangement over the dentition of the patient; andcutting the gingival surface of the patient using the fabricated guide arrangement.3. The method of claim 2 , wherein modifying the gingival surface comprises:cutting the gingival surface along the incision path by positioning a cutting tool against the guide edge of the template portion of the guide ...

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11-07-2013 дата публикации

Articulating Method Including A Pre-Bent Tube

Номер: US20130178708A1
Принадлежит: COVIDIEN LP

A surgical device is provided including an access port having a tubular member with a first ring secured at a proximal end and a second ring secured at a distal end; an articulation structure having an outer tube and an inner tube; and a control mechanism coupled to one end of the inner tube for advancing the inner tube through the outer tube; wherein the outer tube includes at least one rigid section and at least one flexible section and the inner tube includes at least two pre-bent sections. 1. A surgical apparatus comprising:an access port having a tubular member with a first ring secured at a proximal end and a second ring secured at a distal end;an articulation structure having an outer tube and an inner tube; anda control mechanism coupled to one end of the inner tube for advancing the inner tube through the outer tube;wherein the outer tube includes at least one rigid section and at least one flexible section and the inner tube includes at least two pre-bent sections.2. The surgical apparatus according to claim 1 , wherein the inner tube is configured to slidably engage and advance through the outer tube.3. The surgical apparatus according to claim 1 , wherein the inner tube and the outer tube are coaxial.4. The surgical apparatus according to claim 1 , wherein the inner tube defines at least one channel for receiving at least one surgical instrument.5. The surgical apparatus according to claim 1 , wherein the inner tube includes at least two channels.6. The surgical apparatus according to claim 5 , wherein one of the at least two channels is used for at least one of smoke evacuation from a surgical site claim 5 , suction irrigation claim 5 , and inserting an image capture unit therethrough.7. The surgical apparatus according to claim 1 , wherein at least one pre-bent section of the inner tube causes a like direction bend of the flexible section of the outer tube claim 1 , when the at least one pre-bent section engages the flexible section.8. The surgical ...

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25-07-2013 дата публикации

COMPOSITION AND METHOD FOR DETECTING OF MINERALISATION

Номер: US20130189641A1
Принадлежит:

A detection device comprises a proximal end and a light-transmitting portion, wherein the proximal end comprises a light detection means and the light-transmitting portion comprises means for transmitting light along a path from a surface of interest to the light detection means. The light transmitting portion is optimised for use in detecting a low light signal generated by fluorescence or luminescence in conditions of ambient light. The device is adapted to detect the presence of a disclosing substance which has been applied to a surface of interest. 1. A detection device comprising a proximal end and a light-transmitting portion , wherein the proximal end comprises a light detection means and the light-transmitting portion comprises means for transmitting light along a path from a surface of interest to the light detection means , characterised in that the light transmitting portion is optimised for use in detecting a low light signal generated by fluorescence or luminescence in conditions of ambient light; and wherein the device is adapted to detect the presence of a disclosing substance which has been applied to a surface of interest.2. A device according to claim 1 , wherein the light transmitting portion is positioned adjacent to and is adapted to fit around the surface of interest.3. A device according to claim 1 , wherein the low light signal is detected in close succession to the application of the disclosing substance to the surface of interest.4. A device according to claim 1 , wherein the device comprises an elongate member.5. A device according to claim 1 , wherein the proximal end further comprises a lens.6. A device according to claim 5 , wherein the lens is located at a position along the path for transmitting light from a surface of interest to the light detection means.7. A device according to claim 1 , wherein the means for transmitting light is a prism or reflective surface.8. A device according to claim 1 , wherein the device comprises a mirror ...

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01-08-2013 дата публикации

DIAGNOSTIC SYSTEM

Номер: US20130197371A1
Принадлежит:

A diagnostic system comprises a spectral image shooting means that shoots a spectral image within a predetermined wavelength range in a body cavity and obtains spectral image data, an image processing means that obtains the spectral image data and calculates an indicator indicating an area having a high possibility of a diseased portion from the spectral image data, and a monitor on which the indicator is displayed, and wherein the image processing means calculates, as the indicator, a ratio between an accumulated value of intensity values of all spectral images in the predetermined wavelength range and an intensity value of spectral images in a particular wavelength band, for each coordinate in the spectral image. 15-. (canceled)6. A diagnostic system , comprising:a spectral image shooting unit that shoots a spectral image in a body cavity while switching a wavelength of light of a narrow band within a predetermined wavelength range and obtains spectral image data of the predetermined wavelength range;an image processing unit that obtains the spectral image data and calculates an indicator indicating an area having a high possibility of a diseased portion from the spectral image data;a monitor on which the indicator is displayed; andan input unit which receives an input from a user,wherein the image processing unit calculates, as the indicator, a ratio between an accumulated value of intensity values of all spectral images in the predetermined wavelength range and an accumulated value of intensity values of spectral images in a particular wavelength band in the predetermined wavelength range, for each coordinate in the spectral image, andwherein, based on the input from the user, the input unit sets the particular wavelength band within a range of 480 nm to 520 nm.7. The diagnostic system according to claim 6 ,wherein the image processing unit operates to display, on the monitor, an indicator graph which is a graphic representation of the indicator.8. The ...

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08-08-2013 дата публикации

Fluoroscopy Apparatus, Fluoroscopy System, and Fluorescence-Image Processing Method

Номер: US20130201320A1
Принадлежит: Olympus Corp

A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.

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08-08-2013 дата публикации

DENTAL REGISTRATION DEVICE AND METHOD

Номер: US20130203009A1
Принадлежит:

An apparatus for registering occlusal dimensions, comprising a support surface sized and configured for providing areal support to a registration rim; and at least one connector adapted to releasably connect to a dental implant extension. 1. An apparatus for registering occlusal dimensions , comprising:a support surface sized and configured for providing areal support to a registration rim; andat least one connector adapted to releasably connect to a dental implant extension.2. An apparatus according to comprising a registration base member having said support surface at a first end and said at least one connector at a second end opposing said first end.3. An apparatus according to claim 2 , wherein said registration base comprising an occlusal flat solid connectable against a free end of said dental implant extension thereby providing said support surface in occlusal position.4. An apparatus according to claim 3 , wherein said occlusal flat solid is sized and configured for positioning over a chosen bare gingival length.5. An apparatus according to claim 4 , wherein said occlusal flat solid is sized and configured for positioning in-between two laterally positioned teeth.63. An apparatus according to claim 4 , wherein said occlusal flat solid and/or said registration rim is sized for registering a single opposing tooth.7. An apparatus according to claim 2 , wherein said registration base member comprising a vestibular flat solid laterally connectable to said dental implant extension thereby providing said support surface in vestibular position.8. An apparatus according to claim 7 , wherein said vestibular flat solid is textured and configured to harmlessly press against supported soft tissue.9. An apparatus according to claim 8 , wherein said tissue comprising labial mucosa and/or buccal mucosa.10. An apparatus according to claim 2 , wherein said registration base member comprising a mesh.11. An apparatus according to claim 2 , wherein said registration base member ...

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08-08-2013 дата публикации

METHOD FOR CLEARING A BODY LUMEN ENVIRONMENT

Номер: US20130204086A1
Принадлежит: GIVEN IMAGING LTD.

An in vivo sensing device and system may contain or be used in conjunction with an image sensor and a body lumen clearing element or agent. A method may enable clearing a body lumen for in vivo sensing while using the device of the invention. 1. A method of using a lumen clearing element for the clearance of a body lumen , said method comprising:administering into a body lumen a composition containing a lumen clearing element, said lumen clearing element comprising an element selected from the group consisting of: a coagulant, a flocculant, an aggregant, or a combination thereof.2. The method according to claim 1 , wherein said step of administering a composition containing a lumen clearing element comprises administering the composition in two or more discrete dosage forms.3. The method according to claim 1 , wherein said lumen clearing element is in a form selected from the group consisting of: a tablet claim 1 , capsule claim 1 , lozenge claim 1 , powder claim 1 , granule claim 1 , caplet claim 1 , solution claim 1 , suspension claim 1 , emulsion claim 1 , or a combination thereof.4. The method according to claim 1 , wherein said method further comprises the step of administering a clear liquid diet claim 1 , prior to the step of administering the composition containing a lumen clearing element.5. The method according to claim 1 , wherein said method further comprises the step of inserting an in-vivo device into the body lumen claim 1 , following administering the composition containing a lumen clearing element.6. The method according to claim 4 , wherein said in-vivo device is selected from the group consisting of: a swallowable imaging capsule claim 4 , an endoscope claim 4 , a colonoscope and other intra luminal viewing and imaging devices.7. The method according to claim 1 , wherein said method further comprises the step of administering gut-lavage solutions.8. The method according to claim 1 , wherein said body lumen is the colon.9. The method according to ...

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08-08-2013 дата публикации

PROPERTY DETERMINATION APPARATUS FOR DETERMINING A PROPERTY OF AN OBJECT

Номер: US20130204134A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

The invention relates to a property determination apparatus () for determining a property of an object (). Optical sensing data being indicative of an optical property of the object and ultrasound sensing data being indicative of an ultrasound property of the object are generated, and a property determination unit () determines a property of the object based on at least one of the optical sensing data and the ultrasound sensing data. Since light and ultrasound have generally different penetration depths and scattering properties with respect to the object, a property of the object can be determined with good quality, even if the quality of one of the optical sensing data and the ultrasound sensing data is reduced by, for example, a relatively small penetration depth, or if one of the optical sensing data and the ultrasound sensing data is less suitable for determining a desired property of the object. 11. A property determination apparatus for determining a property of an object , wherein the property determination apparatus () comprises:{'b': 6', '7', '73', '3, 'an optical sensor (, , ) for generating optical sensing data being indicative of an optical property of the object (),'}{'b': 10', '3, 'an ultrasound sensor () for generating ultrasound sensing data being indicative of an ultrasound property of the object (),'}{'b': 75', '3, 'a property determination unit () for determining a property of the object () based on at least one of the optical sensing data and the ultrasound sensing data.'}2121621. The property determination apparatus as defined in claim 1 , wherein the property determination apparatus () comprises a catheter () claim 1 , wherein the optical sensor () and the ultrasound sensor are integrated in the catheter ().3143. The property determination apparatus as defined in claim 1 , wherein property determination apparatus () further comprises an energy application element () for applying energy to the object ().4753. The property determination ...

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08-08-2013 дата публикации

METHOD OF DIAGNOSIS AND LOCATION OF A SOFT TISSUE INJURY

Номер: US20130204158A1
Принадлежит:

A method of diagnosing, and determining the position of a microscopic or a macroscopic soft tissue injury or soft tissue stress fracture in a patient. The method includes the steps of determining a pain area on the skin of the patient, applying electromagnetic energy or radiation in a selected portion or range of the visible or infrared spectrums, to parts of the body's surface that correspond with the pain area, obtaining feedback from the patient to determine the sensations that the patient experiences as a result of visible or infrared energy being applied to the tissue at a specific region of pain area, and establishing the site of the microscopic or macroscopic soft tissue injury at the specific region where the sensations are greatest. The visible or infrared energy can be applied using a laser probe. The probe can operated at a selected wavelength or a set of wavelengths in the range of 400 nm to 10,000 ran. The soft tissue injuries to which the present invention may be applicable include injuries that result in symptoms including lower back pain, neck pain, migraines, Type 2 diabetes, sciatica, tinnitus, carpal tunnel syndrome, chronic pain syndrome and fibromyalgia. 1. A method of diagnosing , and determining the position of , a microscopic or a macroscopic soft tissue injury or soft tissue stress fracture in a patient , including the steps of:determining a pain area on the skin of the patient;applying electromagnetic energy or radiation, in a selected portion or range of the visible or infrared spectrums, to parts of the body's surface that correspond with the pain area;obtaining feedback from the patient to determine the sensations that the patient experiences as a result of visible or infrared energy being applied to the tissue at a specific region of pain area; andestablishing the site of the microscopic or macroscopic soft tissue injury at the specific region where the sensations are greatest.2. A method as in wherein the step of determining on the ...

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15-08-2013 дата публикации

SYSTEM FOR NONINVASIVE DETERMINATION OF WATER IN TISSUE

Номер: US20130210058A1
Принадлежит: LAKELAND VENTURES DEVELOPMENT, LLC

An apparatus and method for non-invasive determination of hydration, hydration state, total body water, or water concentration by quantitative spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectroscopy, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance, and calibration transfer. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. 1. An apparatus for determining the hydration state of human tissue by near-infrared spectroscopy comprising:an illuminator configured to illuminate the human tissue with near-infrared light;an optical receiver configured to receive near-infrared from the human tissue;a spectrometer in optical communication with the optical receiver, said spectrometer producing an output indicative of a spectrum; anda processing system configured to receive the output from the spectrometer and determine an output indicative of the hydration state in the human tissue.2. The apparatus according to claim 1 , wherein the illuminator comprises a light homogenizer.3. An apparatus according to wherein the processing system is configured to correlate the determined hydration state of tissue to a hydration state of a body.4. The apparatus according to claim 1 , wherein the illuminator comprises at least one monochromatic light source.5. The apparatus according to claim 1 , wherein the illuminator comprises a resistive element.6. The apparatus according to claim 1 , wherein the illuminator comprises a source of light claim 1 , and a reflector.7. The apparatus according to claim 1 , wherein the illuminator is configured to produce substantially spatially homogeneous and angularly homogeneous near-infrared light.8. The apparatus according to claim 1 , wherein the optical receiver comprises a first optical waveguide in ...

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15-08-2013 дата публикации

HYPEROSMOTIC PREPARATIONS COMPRISING 5-AMINOLEVULINIC ACID OR DERIVATIVE AS PHOTOSENSITIZING AGENT

Номер: US20130211215A1
Принадлежит: PHOTOCURE ASA

Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer. 1. A hyperosmotic preparation comprising a photosensitizing agent and at least one hyperosmotic agent , wherein the photosensitizing agent comprises 5-ALA , a precursor or a derivative thereof.2. The hyperosmotic preparation of which comprises at least one hyperosmotic agent selected from the group consisting of salts claim 1 , sugars claim 1 , sugar alcohols claim 1 , glycerol claim 1 , polyols and combinations thereof.3. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises magnesium sulphate claim 2 , magnesium hydroxide claim 2 , magnesium citrate claim 2 , magnesium chloride claim 2 , sodium phosphate claim 2 , or any combination thereof.4. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises sorbitol claim 2 , mannitol claim 2 , lactitol claim 2 , xylitol claim 2 , lactulose claim 2 , fructose claim 2 , galactose claim 2 , lactose claim 2 , or any combination thereof.5. The hyperosmotic preparation of claim 2 , wherein the hyperosmotic agent comprises a polyether polyol claim 2 , preferably a polyethylene glycol (PEG) or polyethylenepolypropylene glycol (PPG).6. The hyperosmotic preparation of claim 1 , wherein the photosensitizing agent comprises a 5-ALA derivative or a pharmaceutically acceptable salt thereof.7. The hyperosmotic preparation of claim 1 , wherein the photosensitizing agent is a compound of formula I or ...

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15-08-2013 дата публикации

METHODS AND DEVICES FOR GASTROINTESTINAL SURGICAL PROCEDURES USING NEAR INFRARED (nIR) IMAGING TECHNIQUES

Номер: US20130211246A1
Автор: PARASHER Vinod
Принадлежит:

Described herein are methods and devices for performing gastrointestinal surgical procedures using near infrared (nIR) imaging techniques. Described herein are imaging systems, endoscopes, and methods making use of near infrared (nIR) imaging techniques. The imaging systems, endoscopes, and methods can be used, for example, in endoscopic retrograde cholangiopancreatography (ERCP) for visualization of the intraduodenal portion of the bile duct, and in procedures to visualize and to direct treatment of bleeding ulcers, gastrointestinal bleeding, and tumors, for example, a pancreatic mass. 1. An imaging system for an endoscope comprising:a light source capable of emitting near-infrared (nIR) light;an objective lens;an optical filter;an imaging sensor; andan image display unit.2. The imaging system of wherein the light source is capable of emitting nIR light having a wavelength of 800 nm.3. The imaging system of wherein the optical filter is a band-pass filter centered at 830 nm or a long-pass filter excluding light below 810 to 820 nm.4. The imaging system of wherein the light source is further capable of emitting visible light.5. The imaging system of wherein the imaging sensor is a camera.6. The imaging system of wherein the camera is a solid state nIR sensitive camera.7. The imaging system of wherein the image display unit is a monitor.8. The imaging system of wherein said endoscope is adapted for use in endoscopic retrograde cholangiopancreatography (ERCP).9. The imaging system of wherein said endoscope is adapted for use in esophagogastroduodenoscopy (EGD).10. An endoscope comprising:a distal portion for insertion into a patient;a proximal portion which is external to the patient; andan imaging system having a light source capable of emitting near-infrared (nIR) light; an objective lens; an optical filter; and an imaging sensor.11. The endoscope of wherein the light source and objective lens are positioned at a distal end of the endoscope.12. The endoscope of ...

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15-08-2013 дата публикации

MOTION COMPENSATION AND PATIENT FEEDBACK IN MEDICAL IMAGING SYSTEMS

Номер: US20130211261A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

An optical motion sensing system () for use in imaging an anatomical structure employs an optical motion sensor () including a body contour conforming matrix (“BCCM”) () and an optical fiber (). Upon BCCM () being adjoined to the anatomical structure, BCCM () structurally conforms at least partially to a surface contour of the anatomical structure for reciprocating any motion by the anatomical structure. Optical fiber () is at least partially embedded in the BCCM () for generating an encoded optical signal () indicative of a shape of the optical fiber () responsive to any SOS reciprocal motion by the BCCM () during an imaging of the anatomical structure. System () further employs a motion tracker () responsive to encoded optical signal () for periodically reconstructing the shape of optical fiber () with each change in the shape of optical fiber () representing motion by the anatomical structure. 11010. An optical motion sensing system () for use in imaging an anatomical structure , the optical motion sensing system () comprising:{'b': 20', '30', '40, 'claim-text': [{'b': 30', '30, 'wherein, upon the body contour conforming matrix () being adjoined to the anatomical structure, the body contour conforming matrix () structurally conforms at least partially to a surface contour of the anatomical structure for reciprocating any motion by the anatomical structure, and'}, {'b': 40', '42', '40', '30, 'wherein the optical fiber () is at least partially embedded in the body contour conforming matrix for generating an encoded optical signal () indicative of a shape of the optical fiber () responsive to any reciprocal motion by the body contour conforming matrix () during an imaging of the anatomical structure; and'}], 'an optical motion sensor () including a body contour conforming matrix () and an optical fiber (),'}{'b': 50', '42', '40, 'claim-text': {'b': 40', '40, 'wherein each change in a shape of the optical fiber () between the geometric reconstructions of the optical ...

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15-08-2013 дата публикации

PROBE

Номер: US20130211262A1
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP.

A probe includes a plurality of optical fibers that includes an irradiation fiber and a light-receiving fiber; and an optical member of which a base end face is arranged to abut on leading end faces of the optical fibers, and a leading end face is exposed to an outer side. The leading end face of the optical member is perpendicular to a longitudinal direction of the probe. Light emitted from the irradiation fiber passes through a path inclined with respect to a perpendicular line of the leading end face. 1. A probe comprising:a plurality of optical fibers that include an irradiation fiber and a light-receiving fiber; andan optical member of which a base end face is arranged to abut on leading end faces of the optical fibers, and a leading end face is exposed to an outer side,wherein the leading end face of the optical member is perpendicular to a longitudinal direction of the probe and light emitted from the irradiation fiber passes through a path inclined with respect to a perpendicular line of the leading end face.2. The probe according to claim 1 , wherein the optical fibers are arranged such that at least leading end portions are in parallel with each other.3. The probe according to claim 2 , wherein the base end face of the optical member is in parallel with the leading end face of the optical member claim 2 , andthe respective leading end faces of the optical fibers are in parallel with the leading end face of the optical member.4. The probe according to claim 3 , wherein a refractive index of the optical member is substantially equal to a refractive index of cores of the optical fibers.5. The probe according to claim 2 , wherein the base end face of the optical member is not in parallel with the leading end face of the optical member claim 2 , andthe respective leading end faces of the optical fibers are in parallel with the base end face of the optical member.6. The probe according to claim 2 , wherein an inclination angle of a longitudinal direction of the ...

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15-08-2013 дата публикации

INTUBATION GUIDE

Номер: US20130211263A1
Автор: Boedeker Benje
Принадлежит:

Apparatuses for guiding an endotracheal tube during intubation and associated methods of their use; the apparatuses formed to contain a plastic element able to hold deformations so as to conform the apparatus to the shape of a patient's endotracheal airway. The plastic element has sufficient give so as to minimize traumatic engagement with the inner surface of the airway lumen. Methods for using the apparatuses exploit indirect visualization where the person performing the intubation can shape the apparatuses so as to place the distal end into the field of view of the indirect visualization instrument even with minimal alignment of the patient's airway. 1. An apparatus to guide the placement of an endotracheal tube comprising:a plastic element configured to plastically deform and to at least substantially retain a plastic deformation when the apparatus is placed in minimal engagement with an inner surface of an airway lumen to avoid traumatic engagement with the inner surface, anda non-rigid body at least partially encapsulating the plastic element, the non-rigid body configured to prevent contact between the plastic member and the inner surface of the airway lumen,wherein the non-rigid body and the plastic element therein comprise a first end and a distal end, the distal end being configured to be inserted into a field of view of an indirect visualization instrument to facilitate placement of the apparatus in the airway lumen and the first end configured to receive an endotracheal tube for insertion over the apparatus following placement of the apparatus in the airway lumen to guide the endotracheal tube into the airway lumen.2. The apparatus of claim 1 , wherein the non-rigid body is formed of a biocompatible material.3. The apparatus of claim 2 , wherein the biocompatible material comprises at least one of latex claim 2 , silicone claim 2 , polyester claim 2 , nylon claim 2 , rubber claim 2 , or silk.4. The apparatus of claim 1 , wherein the non-rigid body is ...

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22-08-2013 дата публикации

WIRELESS INTRA-ORAL IMAGING SYSTEM AND METHOD

Номер: US20130216971A1
Автор: Friddell Joel
Принадлежит: I PRACTICE MARKETING, LLC

An intra-oral imaging system includes a handheld intra-oral camera in wireless communication with a remote computing device. The computing device includes a display unit and is linked to databases containing historical data for the teeth of a subject. A dentist actuates a touch-sensitive button to prompt capture of images of the subject's teeth, which are wirelessly transmitted to the computing device and graphically displayed. The images generally represent an arrangement and conditions for the teeth. Program modules are executable to identify a current condition of one or more teeth, and to select a prerecorded visual demonstration of a dental procedure from a database based on the identified current condition. Alternatively, the program modules may extrapolate using the current and historical data to predict a future condition and recommend procedures or otherwise alert the subject to potential future procedures. Visual demonstration of the procedures is provided on the display unit. 1. An intra-oral imaging method comprising:causing an intra-oral camera in response to a user trigger to capture video images of a set of one or more teeth of a subject user;generating image data representative of an arrangement and conditions for the set of teeth;transmitting the image data from the intra-oral camera to a computing device via a wireless communication network;generating graphical representations of the set of teeth on a display unit functionally linked to the computing device;identifying a current condition of one or more of the teeth in the set of teeth;selecting a prerecorded visual demonstration of a dental procedure from a database associated with the computing device, based on the identified current condition of the one or more teeth; anddisplaying the demonstration of the dental procedure on the display unit.2. The method of claim 1 , said user trigger comprising a predefined user interaction with a touch-sensitive actuator coupled to the camera.3. The method ...

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22-08-2013 дата публикации

METHODS FOR DIAGNOSIS OF COLORECTAL CANCER

Номер: US20130218023A1
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

Methods and systems for use of phenotypic markers, principally oral mucosal vascular density alone or in combination with detection of other markers, to identify individuals afflicted with or having an increased risk of hereditary colorectal cancer, especially familial adenomatous polyposis, are disclosed. 1. A method for diagnosing familial adenomatous polyposis (FAP) or an increased risk of FAP in a test subject believed to be at risk for such cancer , the method comprising:(a) positioning a sampling area of the oral mucosa of the test subject in a system for measuring the oral mucosal vascular density (OMVD);(b) transilluminating the sampling area of the oral mucosa of the test subject with a light source from the system in a range of wavelengths from 470 nm to 700 nm for a period of time;(c) obtaining at least one or more images of the illuminated sampling area of the test subject using a camera from the system;(d) storing the at least one or more images of (c) on an electronic storage device on a computer;(e) analyzing the at least one or more images of the test subject stored on the electronic storage device to provide an oral mucosal vascular density (OMVD) value from a selected portion of the one or more images; and(f) comparing the OMVD values of the at least one or more images of the test subject to one or more OMVD values of one or more control subjects which are not afflicted with colorectal cancer; and(g) diagnosing the test subject has having adenomatous polyposis (FAP) or an increased risk of FAP when there is found a statistically significant increase in OVMD value in the test subject when compared to the one or more control subjects.26.-. (canceled)7. The method of claim 1 , further comprising analysis of oral mucosal reflectance (OMR) in the one or more subjects compared to controls.8. (canceled)9. The method of claim 7 , wherein the difference between the OMR measurements in the one or more subjects does not differ from the OMR measurements in the ...

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22-08-2013 дата публикации

IMAGING DEVICE AND METHODS OF USING THE SAME

Номер: US20130218027A1
Автор: NAGALE Sandra
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

In one embodiment, a medical device includes a first optical fiber, a second optical fiber, a third optical fiber, and a fourth optical fiber. The first optical fiber is operatively coupled to a first electromagnetic radiation source and is configured to transmit electromagnetic radiation to bodily tissue. The second optical fiber is configured to receive electromagnetic radiation from the first electromagnetic radiation source scattered by the bodily tissue. The third optical fiber is operatively coupled to a second electromagnetic radiation source and is configured to transmit electromagnetic radiation to bodily tissue. The second electromagnetic radiation source is different than the first electromagnetic radiation source. The fourth optical fiber is configured to receive electromagnetic radiation from the second electromagnetic radiation source scattered by the bodily tissue. 1. A medical device , comprising:a first transmitting member operatively coupled to a first electromagnetic radiation source and configured to transmit electromagnetic radiation to bodily tissue;a second transmitting member configured to receive electromagnetic radiation from the first electromagnetic radiation source scattered by the bodily tissue;a third transmitting member operatively coupled to a second electromagnetic radiation source and configured to transmit electromagnetic radiation to the bodily tissue, the second electromagnetic radiation source being different than the first electromagnetic radiation source; anda fourth transmitting member configured to receive electromagnetic radiation from the second electromagnetic radiation source scattered by the bodily tissue.2. The medical device of claim 1 , wherein the first transmitting member is coupled to the second transmitting member claim 1 , the second transmitting member being operatively coupled to a electromagnetic radiation detector.3. The medical device of claim 1 , wherein the first transmitting member claim 1 , the second ...

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22-08-2013 дата публикации

Guidewire with internal pressure sensor

Номер: US20130218032A1
Автор: Claude Belleville
Принадлежит: Opsens Inc

The present document describes a pressure guidewire comprising: a shaft tube with a proximal section; a middle section extending from the proximal section of the shaft tube, the middle section having greater flexibility than the proximal section; an inner hypotube installed substantially within the middle section for optimal mechanical properties; a pressure sensor with a communication means routed through the middle section and the proximal section; and a sensor housing for receiving the pressure sensor. There are also described methods for joining the inner hypotube to the shaft tube.

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29-08-2013 дата публикации

STEERABLE SURGICAL CATHETER HAVING BIOPSY DEVICES AND RELATED SYSTEMS AND METHODS FOR FOUR DIMENSIONAL SOFT TISSUE NAVIGATION

Номер: US20130225943A1
Принадлежит: Veran Medical Technologies, Inc.

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient, wherein the surgical instrument, as provided, may be a steerable surgical catheter with a biopsy device and/or a surgical catheter with a side-exiting medical instrument, among others. Additionally, systems, methods and devices are provided for forming a respiratory-gated point cloud of a patient's respiratory system and for placing a localization element in an organ of a patient. 1. A surgical catheter , comprising:an elongate flexible shaft having a proximal end portion, an opposite distal end portion, a longitudinal axis extending from the proximal end portion to the distal end portion and an outer wall extending from the proximal end portion to the distal end portion;a handle attached to the proximal end portion;a biopsy device at the distal end portion;an actuation wire extending from the proximal end portion to the distal end portion to operate the biopsy device; anda steering mechanism comprising a steering actuator at the proximal end portion and a pull wire connected to the steering actuator wherein the distal end portion may be moved relative to the proximal end portion by manipulating the steering actuator to apply a tension to the pull wire.2. The surgical catheter of wherein an arc of at least 20 degrees may be introduced into the elongate flexible shaft by manipulation of the steering actuator.3. The surgical catheter of wherein an arc of at least 120 degrees may be introduced into the elongate flexible shaft by manipulation of the steering actuator.4. The surgical catheter of wherein manipulation of the steering actuator to introduce an arc of at least 120 degrees into the elongate flexible shaft causes the distal end portion to move such that a distance of no more than 1 inch separates two regions of the elongate flexible shaft located ...

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29-08-2013 дата публикации

IN-VIVO MONITORING WITH MICROWAVES

Номер: US20130225960A1
Автор: Beutler Jan, PORCH Adrian
Принадлежит:

A blood glucose monitor for non-invasive, in-vivo characterisation of a blood glucose level in a living body, the monitor comprising: a microwave resonator having a resonant response to input microwaves and designed such that said response will experience a perturbation by a living body in proximity or contact with the resonator; and detection means for detecting changes in said resonant response from which said level can be characterised. 1. A blood glucose monitor for non-invasive , in-vivo characterisation of a blood glucose level in a living body , the monitor comprising:a microwave resonator having a resonant response to input microwaves and designed such that said response will experience a perturbation by a living body in proximity or contact with the resonator; anda detector arranged to detect changes in said resonant response from which said level can be characterised.2. A monitor according to claim 1 , wherein the resonator is designed to feature a first resonance that will claim 1 , and a second resonance that will not claim 1 , experience a perturbation by a living body in proximity or contact with the resonator.3. A monitor according to claim 2 , wherein one or both of the first and second resonances manifest as a peak in the response.4. A monitor according to claim 2 , wherein the first resonance experiences the perturbation as a change in one or more from a group consisting of frequency claim 2 , phase and amplitude.5. A monitor according to claim 2 , wherein the resonator comprises a housing defining a space with an opening to which said body can be offered claim 2 , the housing including a microwave input to the space claim 2 , a microwave output from the space and a first conductive ring located within the space to produce the first resonance.6. A monitor according to claim 5 , wherein the housing includes a second conductive ring located within the space to produce the second resonance.7. A monitor according to claim 6 , wherein the axes of the ...

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29-08-2013 дата публикации

ELECTROMAGNETIC PROBES, METHODS FOR FABRICATION THEREOF, AND SYSTEMS WHICH USE SUCH ELECTROMAGNETIC PROBES

Номер: US20130225989A1
Принадлежит: Sensible Medical Innovations Ltd.

An electromagnetic (EM) probe for monitoring one or more biological tissues. The EM probe comprises a cup shaped cavity having an opening and an interior volume, a circumferential flange formed substantially around the cup shaped cavity, in proximity to the opening, at least one layer of a material, for absorbing electromagnetic radiation, applied over at least one of a portion of the circumferential flange and a portion of the outer surface of the cup shaped cavity, and at least one EM radiation element which performs at least one of emitting and capturing EM radiation via the interior volume. 1. An electromagnetic (EM) probe for monitoring at least one biological tissue , comprising:a cup shaped cavity having an opening and an interior volume;a circumferential flange formed substantially around said cup shaped cavity, in proximity to said opening;at least one layer of a material, for absorbing electromagnetic radiation, applied over at least one of a portion of said circumferential flange and a portion of the outer surface of said cup shaped cavity; andat least one EM radiation element which performs at least one of emitting and capturing EM radiation via said interior volume.2. The EM probe of claim 1 , wherein said at least one layer covers at least the edge of the bottom surface of said circumferential flange.3. The EM probe of claim 1 , wherein said portion of said at least one layer covers at least 25% of the bottom surface of said circumferential flange.4. The EM probe of claim 1 , wherein at least part of said circumferential flange is set to be detachably connected to said cup shaped cavity.5. The EM probe of claim 4 , wherein said circumferential flange is set to be affixed to a monitored user so as to allow detachably connecting said cup shaped cavity thereto claim 4 , in a manner that said opening faces a skin area of said monitored user.6. The EM probe of claim 1 , wherein said at least one EM radiation element is placed in said interior volume.7. The ...

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05-09-2013 дата публикации

BLOOD SAMPLING DEVICE

Номер: US20130231572A1
Принадлежит:

The position of blood vessels can be more appropriately specified by means of appropriately selecting, on the basis of the conditions and components utilized, and angle between a light emitting unit optical axis of a near-infrared light emitting unit and a normal light of an irradiated surface, and angle between an optical axis of a light receiving side lens and the normal line of the irradiated surface, and an angle between a light receiving surface of a photo diode array and the light receiving unit optical axis. Thus, the subcutaneous blood vessel depth in the direction of the normal line from the irradiated surface can be specified based on changes in illumination intensity in a photodiode array. Consequently, the position of subcutaneous blood vessels can be easily specified. 1. A blood vessel position specifying device which specifies a position of a blood vessel present under skin , the blood vessel position specifying device , comprising:a light projection unit which has a light projection axis having a predetermined angle to a normal line of a predetermined irradiated surface and which projects a near-infrared ray in a direction of an intersection of the light projection axis and the normal line;a spectral lens which is located at the same side as a side where the light projection unit is located relative to the irradiated surface, which receives a reflected light beam of the near-infrared ray projected by the light projection unit, which disperses the reflected light beam, and which has an optical axis having a predetermined angle to the normal line of the irradiated surface;a light receiving unit having a light receiving surface which receives the dispersed reflected light beam; anda blood vessel position calculation unit which calculates a position of the blood vessel based on brightness of the reflected light beam on the light receiving surface,the intersection of the light projection axis and the optical axis of the spectral lens being located at a ...

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12-09-2013 дата публикации

Apparatus and Method for Mitigating Noise Affecting a Transcutaneous Signal

Номер: US20130237787A1
Принадлежит: IVWATCH, LLC

A system and method include a sensor overlying a target area of skin to aid in diagnosing subcutaneous fluid leakage. The sensor includes an absorbent that minimizes noise in detected electromagnetic radiation to make it easier to analyze a signal that is indicative of subcutaneous fluid leakage. 1. A method of evaluating an anatomical change over time in perivascular tissue , the method comprising:emitting a first electromagnetic radiation signal through an epidermis; andabsorbing a second electromagnetic radiation signal, the second electromagnetic radiation signal being a first portion of the first electromagnetic radiation signal that is at least one of reflected, scattered and redirected by the epidermis.2. The method of wherein the second electromagnetic radiation signal impinges on a surface of a housing claim 1 , and absorbing the second electromagnetic radiation signal includes the housing absorbing the second electromagnetic radiation signal.3. The method of wherein emitting the first electromagnetic radiation signal includes a first end face of a first optical fiber emitting the first electromagnetic radiation signal claim 2 , and detecting the third electromagnetic radiation signal includes a second end face of a second optical fiber detecting the third electromagnetic radiation signal claim 2 , and the surface cinctures the first and second end faces.4. The method of claim 3 , comprising potting the first and second optical fibers in the housing.5. The method of wherein potting the first and second optical fibers includes cincturing at least portions of the first and second optical fibers with an electromagnetic radiation absorbing material.6. The method of wherein potting the first and second optical fibers includes injecting epoxy into the housing.7. The method of wherein emitting the first electromagnetic radiation signal comprises a first end face of a first optical fiber emitting the first electromagnetic radiation signal.8. The method of wherein ...

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12-09-2013 дата публикации

Dressing for an Electromagnetic Spectrum Sensor

Номер: US20130237840A1
Принадлежит: IVWATCH, LLC

An epidermal dressing includes a barrier film and a fitting that cooperates with a sensor emitting and detecting near infrared signals for monitoring an intravascular infusion. The barrier film overlies an epidermal insertion site for a cannula administering the intravascular infusion. The fitting includes a first arrangement that retains the sensor and a second arrangement that releases the sensor from the first arrangement. 1. A dressing for coupling a near-infrared sensor and an epidermis , the near-infrared sensor being configured to monitor an intravascular infusion , the dressing comprising:a fitting including a wall at least partially defining a pocket, the fitting having (i) a first arrangement configured to retain the near-infrared sensor in the pocket and (ii) a second arrangement configured to release the near-infrared sensor from the first arrangement; anda frame being coupled to the fitting and configured to overlay an area of the epidermis that is larger than that overlaid by the fitting.2. The dressing of claim 1 , comprising an adhesive configured to couple the frame and the epidermis.3. The dressing of claim 1 , comprising a film occluding the pocket.4. The dressing of wherein the film is approximately transparent to near-infrared signals configured to be emitted and detected by the near-infrared sensor.5. The dressing of wherein the film is configured to substantially prevent passage of solids claim 3 , liquids claim 3 , microorganisms claim 3 , and viruses.6. The dressing of wherein the fitting is relatively more resistant to deformation than the frame.7. The dressing of wherein the fitting includes a flange projecting from the wall.8. The dressing of claim 7 , comprising an adhesive coupling the flange and the frame.9. The dressing of wherein the fitting consists of a first generally homogeneous material claim 1 , the frame consists of a second generally homogeneous material claim 1 , and the first generally homogeneous material is different from ...

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12-09-2013 дата публикации

Apparatus and Method for Mitigating Noise Affecting a Transcutaneous Signal

Номер: US20130237856A1
Принадлежит: IVWatch LLC

A system and method include a sensor overlying a target area of skin to aid in diagnosing subcutaneous fluid leakage. The sensor includes an absorbent that minimizes noise in detected electromagnetic radiation to make it easier to analyze a signal that is indicative of subcutaneous fluid leakage.

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19-09-2013 дата публикации

DETECTING INFECTION IN REDUCED PRESSURE WOUND TREATMENT

Номер: US20130244899A1
Принадлежит: KCI Licensing, Inc.

Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided. 1. A method of detecting infection in a wound caused by an infecting organism at a wound site , the method comprising:applying a reduced pressure to the wound site;withdrawing fluid from the wound site in response to the reduced pressure;collecting the fluid withdrawn from the wound site; andassaying the fluid collected from the wound site for a product of the infection or a component of the infecting organism;whereby the presence of the product or the component indicates the presence of an infection in the wound.2. The method of claim 1 , wherein the infecting organism is a bacterium.3. (canceled)4. The method of claim 1 , wherein the fluid withdrawn is assayed for the product of the infection.5. (canceled)6. (canceled)7. (canceled)8. The method of claim 4 , wherein the product of the infection is a host protein associated with an inflammatory response.9. The method of claim 8 , wherein the host protein is a cytokine claim 8 , a fibronectin fragment claim 8 , a neutrophil protease claim 8 , or a macrophage protease.10. The method of claim 1 , wherein the fluid withdrawn is assayed for the component of an infecting organism.11limulus amebocyte. The method of claim 10 , wherein the component of the infecting organism assayed is lipopolysaccharide (LPS) of Gram negative bacteria claim 10 , which is detected with an assay comprising combining the fluid withdrawn with a lysate or by an assay that primes host neutrophil respiratory burst activity via complement opsonized LPS-IgM immune complexes.12. The method of claim 10 , wherein the component of the infecting organism assayed is lipoteichoic acid (LTA) of Gram positive bacteria claim 10 , which is detected with an assay comprising combining the fluid withdrawn with an ...

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19-09-2013 дата публикации

CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION

Номер: US20130245406A1
Принадлежит:

A method for determining a ratio of hemoglobin absorption within a biological tissue using a handheld device is provided. The method includes focusing at least one light pulse into a predetermined area inside an object using at least one excitation wavelength, wherein a fluorescence signal is based on at least a local excitation optical fluence and properties of fluorophores in the predetermined area. The method further includes receiving a photoacoustic signal emitted by the object in response to the at least one light pulse, the photoacoustic signal being a product of the local excitation optical fluence, an optical absorption coefficient of hemoglobin, and an acoustic detection sensitivity. The method further includes determining the ratio of hemoglobin absorption based on a hemoglobin absorption coefficient that is based at least partially on the fluorescence signal and the photoacoustic signal. 1. A method for determining a ratio of hemoglobin absorption within a biological tissue using a handheld device , said method comprising:focusing at least one light pulse into a predetermined area inside an object using at least one excitation wavelength, wherein a fluorescence signal is based on at least a local excitation optical fluence and properties of fluorophores in the predetermined area;receiving a photoacoustic signal emitted by the object in response to the at least one light pulse, the photoacoustic signal being a product of the local excitation optical fluence, an optical absorption coefficient of hemoglobin, and an acoustic detection sensitivity;determining the ratio of hemoglobin absorption based on a hemoglobin absorption coefficient that is based at least partially on the fluorescence signal and the photoacoustic signal.2. A method according to claim 1 , wherein focusing at least one light pulse comprises focusing at least one light pulse using a focusing assembly that includes an optical assembly of lenses and mirrors.3. A method according to claim 1 , ...

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19-09-2013 дата публикации

Quantification of Under-Eye Skin Color

Номер: US20130245459A1
Автор: Qu Di
Принадлежит: ACCESS BUSINESS GROUP INTERNATIONAL LLC

Methods for quantitative measurement of under eye dark circles and other color related phenomena in eye area skin are described. The methods can be used to quantify the clinical efficacy of skin care products. 1. A method of quantifying an under eye appearance of a human subject , comprising:a. detecting an eye area to be evaluated on a digital image of the human subject;b. selecting a region of interest in the eye area;c. determining skin reflective intensity data within the region of interest;d. generating a skin reflective intensity profile from the intensity data; ande. quantifying a value from the intensity profile of the subject's under eye appearance.2. The method of claim 1 , wherein the region of interest is oval shaped.3. The method of claim 1 , wherein the quantifying step (e) uses a mean square error method to quantify the under eye appearance.4. A method of determining efficacy of a skin care product on a human subject's under eye appearance claim 1 , comprising:a. detecting an eye area to be evaluated on a digital photograph of the human subject;b. selecting a region of interest in the eye area;c. determining skin reflective intensity data within the region of interest;d. generating a skin reflective intensity profile from the intensity data;e. quantifying a pre-treatment value from the intensity profile of the subject's under eye appearance;f. treating the subject with the skin care product;g. repeating steps (a) through (d) after treatment with a skin care product to generate a second intensity profile;h. quantifying a post-treatment value of the subject's under eye appearance from the second intensity profile; andi. comparing the post-treatment value with the pre-treatment value to determine the efficacy of the skin care product.5. The method of claim 4 , wherein the quantifying steps (e) and (h) use a mean square error method to quantify the under eye appearance. This application claims priority to U.S. Application No. 61/611,136 filed Mar. 15, ...

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19-09-2013 дата публикации

Systems and methods for determining patient temperature

Номер: US20130245489A1
Принадлежит: Welch Allyn Inc

A temperature probe includes a handle and a shaft extending from the handle. The shaft includes a distal end, a proximal end, and a tip at the distal end. The temperature probe also includes a capacitance sensor disposed on one of the handle and the shaft, the capacitance sensor configured to measure a change in capacitance when positioned proximate a conductor. The temperature probe further includes a temperature sensor disposed on the shaft, the temperature sensor configured to measure a body cavity temperature of a patient.

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26-09-2013 дата публикации

MEDICAL DEVICE AND TECHNIQUE FOR USING THE SAME

Номер: US20130253310A1
Принадлежит: COVIDIEN LP

According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include interferometry. 1. A medical device for determining placement of a tracheal tube in a subject comprising: receiving information related to received light at a detector for each of a plurality of optical conductors circumferentially spaced apart on a beveled distal end of the tracheal tube, wherein the beveled distal end is slanted relative to a wall of the tracheal tube;', 'receiving information related to an interference between the received light and a reference beam; and', 'determining an orientation of the tracheal tube based upon the interference between the received light and the reference beam for each of the plurality of optical conductors and a difference in path length between the plurality of optical conductors, wherein the difference in path length is representative of a position of each respective optical conductor about the beveled distal end; and, 'a processor configured to execute instructions fora memory storing the instructions.2. The medical device of claim 1 , wherein the processor is configured to execute instructions for determining a distance between a distal end of each of the plurality of optical conductors and an anatomical structure of the subject is determined by altering a distance traveled by the reference beam between a moving reflective surface and a photodetector claim 1 , and determining the distance traveled.3. The medical device of claim 1 , wherein the processor is configured to execute instructions for determining a distance between the tracheal tube and a carina of the subject.4. The medical device of claim 3 , wherein the processor is configured to execute instructions for ...

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26-09-2013 дата публикации

TIME OF FLIGHT BASED TRACHEAL TUBE PLACEMENT SYSTEM AND METHOD

Номер: US20130253311A1
Принадлежит: COVIDIEN LP

According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include time of flight techniques. 1. A medical device for determining placement of a tracheal tube in a subject comprising: drive one or more light sources to emit a light from a plurality of optical conductors circumferentially spaced about a beveled distal end of a tracheal tube disposed in a subject, wherein the beveled distal end is slanted relative to a wall of the tracheal tube;', 'determine a time of flight of the light from each of the plurality of optical conductors based on returned light from a plurality of optical conductors; and', 'determine an orientation of the tracheal tube based upon the time of flight of the light from each of the plurality of optical conductors and a difference in path length between the plurality of optical conductors, wherein the difference in path length is representative of a position of each respective optical conductor about the beveled distal end; and, 'a processor configured to execute instructions toa memory storing the instructions.2. The medical device of claim 1 , wherein the processor is configured to execute instructions to determine a time of flight of a reference claim 1 , and wherein the orientation is determined based upon the time of flight of the returned light from the plurality of optical conductors and the time of flight of the reference.3. The medical device of claim 1 , wherein the orientation is representative of a comparison of a distance between the plurality of optical conductors circumferentially spaced about the beveled distal end tracheal tube and an anatomical structure of the subject.4. The medical device of claim 3 , wherein the anatomical structure ...

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26-09-2013 дата публикации

MEDICAL TOOL THAT EMITS NEAR INFRARED FLUORESCENCE AND MEDICAL TOOL POSITION-CONFIRMING SYSTEM

Номер: US20130253312A1

A medical tool position-confirming system is provided with a medical tool capable of emitting light, the medical tool including a luminescent agent emitting near infrared fluorescence when irradiated with near infrared light having a wavelength within the range of 600 to 1400 nm, the luminescent agent being applied on a surface of the medical tool or kneaded into the medical tool, a light source for directing the near infrared light toward the medical tool a camera for receiving the near infrared fluorescence emitted from the luminescent agent of the medical tool and a monitor for displaying an image taken by the camera The position of the medical tool such as a shunt tube can be confirmed without using an X-ray. 1. A medical tool that emits near infrared fluorescence , the medical tool comprising a luminescent agent emitting near infrared fluorescence when irradiated with near infrared light having a wavelength within the range of 600 to 1400 nm , the luminescent agent being applied on a surface of the medical tool or kneaded into the medical tool.2. The medical tool that emits near infrared fluorescence according to claim 1 , wherein a main body of the medical tool is a shunt tube claim 1 , and the luminescent agent is applied on an entire surface of the main body or kneaded into the entire main body.3. A medical tool position-confirming system comprising:a medical tool capable of emitting light, the medical tool including a luminescent agent emitting near infrared fluorescence when irradiated with near infrared light having a wavelength within the range of 600 to 1400 nm, the luminescent agent being applied on a surface of the medical tool or kneaded into the medical tool;a light source for directing the near infrared light toward the medical tool;a camera for receiving the near infrared fluorescence emitted from the luminescent agent of the medical tool; anda monitor for displaying an image taken by the camera.4. The medical tool position-confirming system ...

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03-10-2013 дата публикации

COMPOSITION

Номер: US20130260341A1
Принадлежит:

The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth. 1. A photosensitive composition comprising:synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion; and{'sub': 4', '2, 'one or more synthetic minerals of formula CaHPO.xHO, wherein x is 0, 1 or 2.'}2. A photosensitive composition as claimed in wherein the one or more CaHPO.xHO minerals is monetite or brushite.3. A photosensitive composition as claimed in claim 1 , wherein the one or more CaHPO.xHO minerals is monetite and brushite.4. A photosensitive composition as claimed in claim 1 , wherein the nanocrystalline hydroxyapatite or synthetic precursor thereof is fluoride ion-substituted.5. A photosensitive composition as claimed in claim 1 , wherein the nanocrystalline hydroxyapatite or synthetic precursor thereof is further doped with aluminium ions.6. A photosensitive composition as claimed in claim 1 , wherein the rare earth ion exhibits absorption bands which substantially match or overlap one or more absorption bands of the synthetic nanocrystalline hydroxyapatite.7. A photosensitive composition as claimed in claim 1 , wherein the rare earth ion is an erbium claim 1 , ytterbium claim 1 , holmium or thulium ion.8. A photosensitive composition as claimed in claim 1 , obtained or obtainable by a process comprising:(a) preparing an aqueous mixture of a calcium ion-containing solution, a phosphate ion-containing solution, and a rare earth ion-containing dopant solution at a pH in the range 5 to 14;(b) causing the formation of nanocrystalline hydroxyapatite doped with a rare earth ion; and(c) isolating the photosensitive composition.9. A photosensitive composition as ...

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03-10-2013 дата публикации

APPARATUS AND METHOD FOR MEASURING BIOLOGICAL SIGNAL

Номер: US20130261405A1
Автор: CHO Jae-Geol, Lee Sang-Hun
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

An apparatus and method for easily and accurately measuring a biological signal by using a wristwatch-type measurement module. After a band of the wristwatch-type measurement module is tightened to wear on a user's wrist, the band is further tightened to make the wristwatch-type measurement module closely contact the user's wrist. An operation mode of the wristwatch-type measurement module closely contacting the user's wrist is switched from a normal mode to a measurement mode, and a user's biological signal is measured from the user's wrist through the wristwatch-type measurement module in the measurement mode. The user's biological signal is then displayed through the wristwatch-type measurement module. 1. An apparatus for measuring a biological signal , the apparatus comprising:a first tightening portion for tightening a band of a wristwatch-type measurement module to wear on a user's wrist;a second tightening portion for further tightening the band to make the wristwatch-type measurement module closely contact the user's wrist;a button unit for switching an operation mode of the wristwatch-type measurement module;a sensor unit for measuring a user's biological signal from the user's wrist which the wristwatch-type measurement module closely contacts; anda display unit for displaying the user's biological signal.2. The apparatus of claim 1 , wherein the button unit switches the operation mode of the wristwatch-type measurement module from a normal mode to a measurement mode when the wristwatch-type measurement module closely contacts the user's wrist.3. The apparatus of claim 2 , wherein the sensor unit measures a user's Electrocardiogram (EKG) or Photoplethysmography (PPG) signal from the user's wrist when in the measurement mode.4. The apparatus of claim 2 , wherein the sensor unit measures at least one of a number of heartbeats claim 2 , blood pressure claim 2 , a blood oxygen saturation level claim 2 , a heart rhythm claim 2 , a number of breaths claim 2 , ...

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03-10-2013 дата публикации

System for Inducing Respiration Using Biofeedback Principle

Номер: US20130261424A1

Disclosed herein is a system for processing a biofeedback-treated, respiration-induced signal image using the biofeedback principle, wherein a process for processing the respiration-induced signal image comprises the steps of: (a) acquiring a respiration-induced signal image from a treatment site of a patient in need of radiotherapy treatment using a photographing device; (b) binarizing the acquired image of step (a) using a threshold value; (c) determining whether the binarized image of step (b) is distorted; (d) synthesizing the image; (e) determining whether the synthesized image is required to be separated into regions; and (f) performing pattern matching for the respiration-induced signal image. According to the system, a patient can see and control the patient's own motion at a place where the patient's steady respiration or motion is required, and thus the stability of the patient in a radiotherapy treatment process can be ensured. 1. A system for processing a biofeedback-treated , respiration-induced signal image , wherein a process for processing the respiration-induced signal image comprises the steps of:(a) acquiring a respiration-induced signal image from a treatment site of a patient in need of radiotherapy treatment using a photographing device;(b) binarizing the acquired image of step (a) using a threshold value;(c) determining whether the binarized image of step (b) is distorted;(d) synthesizing the image;(e) determining whether the synthesized image is required to be separated into regions; and(f) performing pattern matching for the respiration-induced signal image.2. The system of claim 1 , wherein the process for processing the respiration-induced signal image further comprises step (g) of performing edge detection if it is determined in step (c) that the binarized image is distorted.3. The system of claim 2 , wherein a mask which is used for the edge detection of step (g) is one or more selected from the group consisting of Prewitt claim 2 , ...

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03-10-2013 дата публикации

INTERVENTIONAL APPARATUS ACTIVATED COMPUTED TOMOGRAPHY (CT)

Номер: US20130261439A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

A system () includes an interventional apparatus () and an imaging scanner (). The interventional apparatus includes a interventional instrument () configured to perform an image-guided interventional procedure for a patient. The interventional apparatus includes a position detector () that detects a position of the interventional instrument within a region of the patient at which the image-guided interventional procedure is performed from outside of the region of interest and generates a signal indicative of the detected position. The imaging scanner includes a controller () that activates the imaging scanner to scan the region of interest and the interventional instrument therein for one or more data acquisition cycles based on the movement signal. 1. A system , comprising:an interventional apparatus including a interventional instrument configured to perform an image-guided interventional procedure for a patient, the interventional apparatus including a position detector that detects a position of the interventional instrument within a region of the patient at which the image-guided interventional procedure from outside of the region of interest is performed and generates a movement signal indicative of the detected position; andan imaging scanner including a controller that activates the imaging scanner to scan the region of interest and the interventional instrument therein for one or more data acquisition cycles based on the movement signal.2. The system of claim 1 , the interventional apparatus claim 1 , comprising:a sheath configured to provide an entry point into a vessel of the patient when inserted into the patient;a catheter, to which the interventional instrument is affixed, configured to be fed through the sheath and into the vessel and routed through the vessel to position of the interventional instrument within the region of interest; anda position detector, affixed to the sheath and located outside of the patient, that senses movement of the ...

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10-10-2013 дата публикации

Optical Monitoring and Computing Devices and Methods of Use

Номер: US20130267854A1
Принадлежит:

The present invention relates to medical devices and, in particular, to optical computing devices configured to monitor cardiac-related conditions. One optical computing device includes a substrate, at least one light source mounted on the substrate and configured to emit electromagnetic radiation that optically interacts with a vasculature and generates an optically interacted signal, a plurality of detectors mounted on the substrate and configured to detect the optically interacted signal, and a stabilizing matrix arranged on the substrate and substantially surrounding the at least one light source and the plurality of detectors. The stabilizing matrix may be configured to absorb vibration and thereby reduce motion artifacts detectable by the plurality of detectors. 1. A device , comprising:a substrate;at least one light source mounted on the substrate and configured to emit electromagnetic radiation that optically interacts with a vasculature and generates an optically interacted signal;a plurality of detectors mounted on the substrate and configured to detect the optically interacted signal; anda stabilizing matrix arranged on the substrate and substantially surrounding the at least one light source and the plurality of detectors, the stabilizing matrix being configured to absorb vibration and thereby reduce motion artifacts detectable by the plurality of detectors.2. The device of claim 1 , wherein the electromagnetic radiation is one of red or infrared light.3. The device of claim 1 , wherein the plurality of detectors form a circular array about the light source.4. The device of claim 1 , further comprising a processing device communicably coupled to the plurality of detectors and configured to receive signal data generated by the plurality of detectors.5. The device of claim 5 , wherein the processing device is a wireless transmitter configured to communicate the signal data to an adjacent computing system adapted to receive and process the signal data.6. ...

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