10-01-2019 дата публикации
Номер: US20190010170A1
Принадлежит:
Profusa, Inc.
Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided. 189-. (canceled)91. The compound of claim 90 , wherein Lis a bond claim 90 , or an optionally substituted group selected from phenylene claim 90 , pyridyl claim 90 , pyrimidyl claim 90 , pyrazinyl claim 90 , thienyl claim 90 , furanyl claim 90 , pyrrolyl claim 90 , pyrazolyl claim 90 , thiazolyl claim 90 , oxazolyl claim 90 , imidazolyl claim 90 , indolyl claim 90 , benzimidazolyl claim 90 , indazolyl claim 90 , benzotriazolyl claim 90 , isoquinolyl claim 90 , quinolyl claim 90 , benzothiazolyl claim 90 , benzofuranyl claim 90 , pyrazolopyridyl claim 90 , quinazolinyl claim 90 , quinoxalinyl claim 90 , and cinnolinyl claim 90 , and.93. The compound of claim 90 , wherein Yis SiMe.94. The compound of claim 90 , wherein Ror Ris —NHC(O)C(CH)CH claim 90 , or both Rand Rare —NHC(O)C(CH)CH.95. The compound of claim 90 , wherein R claim 90 , R claim 90 , R claim 90 , and Rare —CHor —H.96. The compound of claim 90 , wherein Lis optionally substituted C-Calkyl claim 90 , optionally substituted C-Cheteroalkyl claim 90 , or (CHCHO)pCHCH claim 90 , wherein p is 2 claim 90 , 3 claim 90 , 4 claim 90 , or 5.97. The compound of claim 90 , wherein Lis optionally substituted C-Calkyl claim 90 , optionally substituted C-Cheteroalkyl claim 90 , or (CHCHO)pCHCH claim 90 , wherein p is 2 claim 90 , 3 claim 90 , 4 claim 90 , or 5.98. The compound of claim 90 , wherein R claim 90 , R claim 90 , and Rare H.99. The compound of claim 90 , wherein R claim 90 , R claim 90 , R claim 90 , and Rare H.100. The compound of claim 90 , wherein both Rare H claim 90 , and Rat each occurrence is independently selected from the group consisting of H; an electron-withdrawing group selected from the group consisting of halogen claim 90 , C(O)R′ claim 90 , COOR′ claim 90 , C(O)NH claim 90 , C(O)NR′R″ claim 90 , CF claim 90 , CN claim 90 ...
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