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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 2794. Отображено 100.
05-01-2012 дата публикации

Protrudent analyte sensor

Номер: US20120004524A1
Автор: Nannette M. Van Antwerp, Udo Hoss
Принадлежит: Medtronic Minimed Inc

The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.

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Номер записи: 1
26-04-2012 дата публикации

Molecular exchange device

Номер: US20120097600A1
Автор: Mark Thomas O'connell, Rodney Ruston, Stewart Jeffrey Block
Принадлежит: Probe Scientific Ltd

The present relates to a molecular exchange device. In particular, the molecular exchange device comprises at least one fluid passageway; and an actuator, the actuator positioned to provide a secondary fluid passageway within at least one of the fluid passageways.

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Номер записи: 2
14-06-2012 дата публикации

Blood collection devices containing blood stabilization agent

Номер: US20120149004A1
Автор: Craig A. Gelfand, Daniel Marchiarullo, Keith Moskowitz
Принадлежит: Becton Dickinson and Co

Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also provided.

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Номер записи: 3
13-09-2012 дата публикации

Bodily fluid composition analyzer with disposable cassette

Номер: US20120232362A1
Автор: James R. Braig, Jennifer H. Gable, Kenneth I. Li, Mark Wechsler, PENG Zheng, Richard Keenan
Принадлежит: Optiscan Biomedical Corp

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

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Номер записи: 4
22-11-2012 дата публикации

Manufacturing electrochemical sensor module

Номер: US20120291254A1
Автор: James L. Say
Принадлежит: Individual

Certain processes for manufacturing an electrochemical sensor module include assembly first and second housing portions of sensor modules; dispensing a sensor fiber across multiple first housing portions; joining the first and second housing portions; and separating the sensor modules by cutting the sensor fiber.

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Номер записи: 5
14-02-2013 дата публикации

Arrangement for detection of hemolysis

Номер: US20130040333A1
Автор: Mathias Karlsson
Принадлежит: Hemcheck Sweden Ab

The present invention relates to a device for visual detection of hemolysis in a whole blood sample, comprising at least one visible detection compartment and a transfer passage connected to said visible detection compartment, said transfer passage being arranged to permit transfer of a volume of plasma from said sample to said detection compartment and wherein said transfer passage further is arranged with a separation device ( 4 ) for separating plasma from blood cells within said whole blood sample before said plasma reaches the detection compartment, wherein said device is arranged with subpressure means providing a subpressure inside said detection compartment for generating a force urging said volume of plasma to be transferred from said whole blood sample to said detection compartment through said transfer passage and via said separation device.

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Номер записи: 6
14-03-2013 дата публикации

Vessel for blood sampling

Номер: US20130066234A1
Автор: Elke Helftenbein
Принадлежит: PreAnalytiX GmbH

The present invention relates to a vessel for withdrawing blood, the vessel containing a solution which comprises a guanidinium salt, a buffer substance, a reducing agent, and/or a detergent as components. The vessel is particularly suited for withdrawing blood which is to be analyzed with respect to nucleic acids.

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Номер записи: 7
28-03-2013 дата публикации

SYSTEMS AND METHODS FOR PARENTERALLY PROCURING BODILY-FLUID SAMPLES WITH REDUCED CONTAMINATION

Номер: US20130079604A1
Автор: Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media. 120.-. (canceled)21. A method of obtaining a bodily fluid sample from a patient , the method comprising:inserting a first needle into the patient;inserting into a pre-sample reservoir a second needle fluidically coupleable to the first needle;receiving a first volume of bodily fluid into the pre-sample reservoir;after the first volume of bodily fluid has been received into the pre-sample reservoir, removing the second needle from the pre-sample reservoir;inserting the second needle into a first sample vessel; andreceiving a second volume of bodily fluid into the first sample vessel.22. The method of claim 21 , further comprising:after the second volume of bodily fluid has been received into the first sample vessel, removing the second needle from the first sample vessel.23. The method of claim 22 , further comprising:inserting the second needle into a second sample vessel; andreceiving a third volume of bodily fluid into the second sample vessel.24. The method of claim 23 , further comprising:after the third volume of bodily fluid has been received into the second sample vessel, removing the second needle from the second sample vessel.25. The method of claim 24 , further comprising:removing the first needle from the patient.26. The method of claim 21 , wherein the first sample vessel contains a culture medium that is ...

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Номер записи: 8
04-04-2013 дата публикации

Low-pressure packaging for fluid devices

Номер: US20130081960A1
Автор: Kevin Schott
Принадлежит: Seventh Sense Biosystems Inc

Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein.

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Номер записи: 9
02-05-2013 дата публикации

Simultaneous acquisition of biometric data and nucleic acid

Номер: US20130106568A1
Автор: Lori Hennessy, Michael Harrold, Robert Lagace
Принадлежит: Life Technologies Corp

Disclosed are devices and methods for collection and analyzing biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature of a test subject, while keeping the sample and signature associated with each other. Such devices and methods are used in forensic, human identification, screening, and access control technologies to rapidly process an individual's identity or determine the identity of an individual.

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Номер записи: 10
09-05-2013 дата публикации

Sample cell for fluid analysis system

Номер: US20130114068A1
Автор: Eugene Lim, Roger Tong
Принадлежит: Optiscan Biomedical Corp

Systems and method are disclosed for determining a concentration of an analyte (e.g., glucose) in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A centrifuge motor can spin the sample cell to separate the fluid into a plurality of components (plasma, red blood cells, etc.). A particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell after centrifuging such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a cuvette that has two window pieces sandwiched between two clamshell pieces, and where the sample portion of the sample cell is defined by a gap between the window pieces.

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Номер записи: 11
16-05-2013 дата публикации

Systems and methods for determining physiological parameters using measured analyte values

Номер: US20130123592A1
Автор: Peter Rule
Принадлежит: Optiscan Biomedical Corp

Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

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Номер записи: 12
23-05-2013 дата публикации

Diagnostic system

Номер: US20130131479A1
Автор: Alison Ruth Norcott, Christopher David Dunn, Eric Siu, Ernesto Monis Hueso, Ian Frederick Johnson, John Michael Kelly, Richard Sokolov
Принадлежит: Individual

A composite diagnostic system comprising a support member having a membrane penetration element; a bodily fluid collection point positioned for collection of a bodily fluid released by application of the membrane penetration element to a user's body; a test material positioned in the support member such that in use the bodily fluid is brought into contact with the test material.

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Номер записи: 13
30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9
Автор: A. David Boccuti, Christopher J. Morse, Donald E. Chickering, III, Greg Fisher, Javier Gonzalez-Zugasti, Maisam Dadgar, Mark Michelman, Ramin Haghgooie, Richard L. Miller, Scott James, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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Номер записи: 14
27-06-2013 дата публикации

Fluid injection and safety system

Номер: US20130160532A1
Автор: Eugene Lim, Gil Rivas, Jeffrey T. Chiou, Michael Butler
Принадлежит: Optiscan Biomedical Corp

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

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Номер записи: 15
27-02-2014 дата публикации

Fluid handling cassette

Номер: US20140058228A1
Автор: James R. Braig, Jennifer H. Gable, Kenneth I. Li, Mark Wechsler, PENG Zheng, Richard Keenan
Принадлежит: Optiscan Biomedical Corp

A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

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Номер записи: 16
13-03-2014 дата публикации

Apparatus and method for manually powered bodily fluid extraction

Номер: US20140073992A1
Автор: Hoi-Cheong S. Sun, Kevin A. Hufford
Принадлежит: Charles Stark Draper Laboratory Inc

Apparatuses and methods are disclosed herein for extracting bodily fluids. The apparatus consists of a housing, a releasable lancet stored in the housing, an inlet flow channel formed in the housing, a mechanically powered vacuum generator, and a storage area formed in the housing. The releasable lancet is released to pierce the skin of the subject to allow fluid to be extracted from the subject. The vacuum generator generates a partial vacuum within the inlet flow channel. After the lancet has pierced the skin of the subject, the partial vacuum draws fluid from the subject and into the inlet flow channel. The storage area is in fluid connection with the inlet flow channel, and receives the fluid drawn from the subject from the inlet flow channel.

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Номер записи: 17
13-03-2014 дата публикации

Closed-circuit device and methods for isolation, modification, and re-administration of specific constituents from a biological fluid source

Номер: US20140074007A1
Автор: Gary L. Mcneil
Принадлежит: Individual

The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system. The methods and apparatus may also be employed as a closed system allowing the on-line purification and/or modification of a target molecule or biomolecule from a fluid source such as a bioreactor or perfusion bioreactor.

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Номер записи: 18
06-01-2022 дата публикации

COLLECTION AND TREATMENT OF A BIOFLUID SAMPLE

Номер: US20220000457A1
Автор: FABRIZIO Eve F., HENDRIX Pamela, HOLLER Kraig, KEYGHOBAD Seyamak, KLEIN Jessica, PATEL Bindi, ZITEK Trevor
Принадлежит:

A system can facilitate pre-treatment a biofluid sample for various applications for monitoring and/or tracking a subject's health. The system includes a sample collection component that can collect the biofluid sample. The system also includes a mixing component that includes a media with a material. Upon adding the biofluid sample to the mixing component, the biofluid sample mixes with the media. The system also includes a filter component that can filter the media from the biofluid sample. After the media is filtered from the biofluid sample, the biofluid sample can be provided to an analyte analysis application. 1. A method comprising:adding a biofluid sample to a media comprising a carbon-containing material, wherein the biofluid sample comprises a liquid, an analyte and at least one contaminant;mixing the biofluid sample and the media to reduce a concentration of the at least one contaminant in the biofluid sample;filtering the media from the biofluid sample,wherein the mixing and/or the filtering uses a mechanical mechanism; andproviding the biofluid sample for analysis.2. The method of claim 1 , wherein the analysis comprises the detecting the analyte in the biofluid sample.3. The method of claim 1 , wherein the carbon-containing material eliminates at least a portion of the at least one contaminant in the biofluid sample.4. The method of claim 1 , wherein the carbon-containing material comprises activated charcoal claim 1 , activated carbon claim 1 , carbon black claim 1 , graphite claim 1 , graphene claim 1 , oxidized graphene claim 1 , and/or reduced graphene.5. The method of claim 1 , further comprising collecting the biofluid sample claim 1 , wherein the biofluid sample comprises a bodily fluid.6. The method of claim 5 , wherein the bodily fluid comprises tears claim 5 , saliva claim 5 , urine claim 5 , serum claim 5 , plasma claim 5 , and/or blood.7. The method of claim 1 , wherein the analysis comprises detecting an amount of the analyte in the ...

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Номер записи: 19
03-01-2019 дата публикации

Procoagulant factors suitable for subsequent autologous use

Номер: US20190000367A1
Автор: Niels Erik Holm, Rasmus Lundquist
Принадлежит: Reapplix AS

Provided is a blood collection unit suitable for accelerated blood coagulation of whole blood for subsequent autologous or allogeneic use. The blood collection unit includes an inside surface that an activation site accelerating coagulation by having a high roughness. Further provided is a blood collection unit including an inside surface that has an activation site having a high roughness area, and an interior of the blood collection unit has been prepared with a pressure of no more than 255 mBar, and preferably a pressure of no more than 130 mBar.

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Номер записи: 20
04-01-2018 дата публикации

METHODS AND SYSTEMS FOR HYBRID OVERSIGHT OF SAMPLE COLLECTION

Номер: US20180000396A1
Автор: Balwani Sunny
Принадлежит:

Methods for obtaining a sample from a subject include providing a sample collection room. Samples may be small, e.g., a finger-stick. A method is provided for sample collection comprising: obtaining, in a sample collection room, a sample from said body part of said subject; monitoring activity in the sample collection room using at least two motion capture devices positioned to view a field of interest in the sample collection room; and alerting a technician performing the sample collection if a non-conforming action by the technician is detected by at least one of the motion capture devices. 1. A method for sample collection from a subject , said subject having a body part , the method comprising:obtaining, in a sample collection room, a sample from said body part of said subject;monitoring activity in the sample collection room using at least two motion capture devices positioned to view a field of interest in the sample collection room; andalerting a technician performing the sample collection if a non-conforming action by the technician is detected by at least one of the motion capture devices.2. The method of wherein alerting comprises providing instructions for at least one corrective action to the technician to remedy the non-conforming action.3. The method of wherein alerting further comprises connecting a human by way of a telecommunication link to the technician to guide the technician in at least one corrective action related to the non-conforming action.4. The method of wherein the corrective action comprises changing angulation of a sample collection device relative to horizontal.5. The method of wherein the corrective action comprises using a sample collection device with a different anti-coagulant therein.6. The method of wherein the corrective action comprises applying a warming device to a target tissue for a longer period of time.7. The method of further comprising attaching at least one motion capture reflective element to the technician.8. The ...

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Номер записи: 21
05-01-2017 дата публикации

INTEGRATED TESTING DEVICE

Номер: US20170001192A1
Автор: DUNN Christopher David, HUESO Ernesto Monis, JOHNSON Ian Frederick, KELLY John Michael, NORCOTT Alison Ruth, Sokolov Richard, SUI Eric
Принадлежит: ATOMO DIAGNOSTICS PTY LIMITED

An integrated testing device and method are disclosed. The device includes an integral reservoir for a test fluid, and an actuator, so that the test fluid can be dispensed to facilitate the test. 1. An integrated testing device comprising:a test component;a reservoir adapted to contain a test fluid; anda fluid delivery actuator, wherein operation of the fluid delivery actuator causes the test fluid to be released from the reservoir so as to contact the test component.2. An integrated testing device according to claim 1 , wherein the device further includes a receptacle for receiving a bodily fluid claim 1 , so that the bodily fluid contacts or can be caused to contact the test component.3. An integrated testing device according to claim 2 , wherein the actuator is adapted to be manually operated.4. An integrated testing device according to claim 1 , wherein an interlock prevents the release of the test fluid until a specific stage in the test process.5. An integrated testing device according to claim 4 , wherein an interlock prevents the release of the test fluid until the bodily fluid has contacted the test component.6. An integrated testing device according to claim 1 , wherein the test component is removable from the diagnostic system.7. An integrated testing device according to claim 1 , wherein the actuator is adapted to enable the release a controlled amount of test fluid.8. An integrated testing device according to claim 1 , wherein the device comprises a plurality of reservoirs adapted to contain test fluids.9. An integrated testing device according to claim 1 , wherein the or each reservoir is a separately formed sachet.10. An integrated testing device according to claim 9 , wherein the sachet is formed so that when pressure is applied by the actuator claim 9 , test fluid is emitted from a specific site on the sachet.11. Am integrated testing device according to claim 10 , wherein the actuator comprises a button located on the housing of the device.12. An ...

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Номер записи: 22
07-01-2016 дата публикации

Blood and Marrow Draw Processing Devices and Methods

Номер: US20160003712A1
Автор: Brian Leach, Christopher J. Centeno, Patrick REISCHLING, Ryan Dregalla
Принадлежит: REGENERATIVE SCIENCES LLC

Apparatus, systems and methods for processing a blood sample. One embodiment comprises an isolation container having at least one sidewall defining an interior volume. The interior volume includes a medial reservoir in fluid communication with proximal and distal reservoirs. The diameter of the medial reservoir is less than the diameter of the proximal and distal reservoirs. Therefore, the isolation container has an interior volume which is roughly hour-glass shaped with the medial reservoir being a substantially narrowed portion or channel between two wider portions. The isolation container is configured such that the buffy coat layer of fractionated blood will be located within and may be accessed from the reduced cross sectional medial reservoir after a centrifuge or other processing step.

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Номер записи: 23
07-01-2016 дата публикации

IN VITRO METHOD, USE OF AN AGENT AND COLLECTION DEVICE FOR THE INHIBITION OF COAGULATION IN BLOOD

Номер: US20160003853A1
Автор: Bissé Emmanuel
Принадлежит:

The present invention relates to a method and a use of an agent for the in vitro inhibition of coagulation in blood and a blood collection device provided for said method and use. 1. An in vitro method for the inhibition of coagulation in blood , wherein blood is mixed after its withdrawal with an agent comprising as the only anticoagulant a substance provided as free acid having a pKof ≧0.9.2. The method according to claim 1 , wherein the substance provided as free acid having a pKof ≧0.9 denotes a substance provided as free carboxylic acid having a pKof ≧0.9.3. The method according to claim 1 , wherein said substance provided as free acid having a pKof ≧0.9 comprises at least two carboxyl groups per molecule claim 1 , preferably comprises at least three carboxyl groups per molecule.4. The method according to claim 1 , wherein said agent consists of{'sub': 'a', '(i) said substance provided as free acid having a pKof ≧0.9; or'}{'sub': 'a', '(ii) said substance provided as free acid having a pKof ≧0.9 dissolved in a solvent.'}5. The method according to claim 1 , wherein subsequently at least one test is carried out for the determination of at least one blood component.6. The method according to claim 1 , wherein the concentration of said substance provided as free acid having a pKof ≧0.9 is at least 0.1 mmol/L of blood to be mixed with.7. The method according to claim 4 , wherein in case (ii) the solvent is selected from the group consisting of an aqueous solution claim 4 , water claim 4 , and alcohol and mixtures of water and alcohol.8. The method according to claim 1 , wherein the amount of at least one blood component is determined claim 1 , by comprising the following steps:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'sub': 4', '1', '6', '3', '6, '(a) providing a blood collection device containing, placed in the device, the agent as set forth in , optionally further containing a pH modifying agent and/or an ammonium salt NRX, wherein each R independently is ...

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Номер записи: 24
01-01-2015 дата публикации

DETERMINING A PRESENCE OF TARGET MOLECULES IN A BODY FLUID COMPRISING CELLS

Номер: US20150004624A1
Автор: De Kievit Peggy, De Regt Bram, Dittmer Wendy Uyen, Orsel Joukje Garrelina
Принадлежит:

A method of determining a presence of target molecules in a body fluid () with cells comprises the steps of: lysing cells in the body fluid () for generating a lysate (); mixing the lysate () with particles () with first detector molecules; binding target molecule to the particles through first detector molecules; exposing a substrate () with second detector molecules to the lysate (); binding target molecules to the substrate through second detector molecules; detecting particles () attached to the substrate (). 116. A method of determining a presence of target molecules in a body fluid () comprising cells , the method comprising the steps of:{'b': 16', '17, 'lysing cells in the body fluid () for generating a lysate ();'}{'b': 16', '36, 'mixing the lysate () with particles () with first detector molecules;'}binding target molecules to the particles through first detector molecules;{'b': 38', '17, 'exposing a substrate () with second detector molecules to the lysate ();'}binding target molecules to the substrate through second detector molecules;{'b': 36', '36, 'detecting particles () attached to the substrate ();'}{'b': 16', '26', '14, 'wherein the cells of the body fluid () are lysed in a first place () of a cartridge ();'}{'b': 36', '30', '14, 'wherein the lysate is mixed with the particles () in a second place () of the cartridge ().'}2. The method of claim 1 ,wherein the cells are lysed by a detergent or a mixture of detergents.3. The method of claim 2 ,wherein the detergent comprises at least one of Nonidet-P40, Nonidet-P40 substitute, sucrose monolaurate, Chemal LA-9 and Triton X100.4. The method of claim 2 ,wherein at least a salt is added to the detergent in absence of proteins and carbohydrates.5. The method of claim 1 ,wherein the cells are lysed by a physical lysing method.6. The method of claim 1 ,{'b': '16', 'wherein the lysate is mixed with the particles and/or the substrate is exposed to the lysate after a specific time after the start of the lysis ...

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Номер записи: 25
03-01-2019 дата публикации

Blood Collection Tube, Reagent, and Method for Analyzing Blood Characteristics Using Same

Номер: US20190004031A1
Автор: HASEGAWA Takaaki, HOSOKAWA KAZUYA, Kaneko Hisayo, Nagasato Tomoka, Wada Tomoko
Принадлежит:

A method for analyzing thrombogenic capacity or blood coagulation capacity, the method comprising adding calcium, a blood coagulation factor XII (FXII) inhibitor, and a kallikrein inhibitor to blood collected with a blood collection tube containing sodium citrate, to allow initiation of blood coagulation reaction, is provided. Preferably, heparin, heparan sulfate, and tissue factor are further added to the blood, and thrombogenic capacity or blood coagulation capacity is analyzed. 1. A method for analyzing thrombogenic capacity or blood coagulation capacity , the method comprising adding calcium , a blood coagulation factor XII (FXII) inhibitor , and a kallikrein inhibitor to blood collected with a blood collection tube containing sodium citrate , to allow initiation of blood coagulation reaction.2. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 1 , wherein the FXII inhibitor is corn-derived trypsin inhibitor (CTI).3. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 2 , wherein the concentration of CTI is 5 μg/mL to 200 μg/mL.4. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 1 , wherein the kallikrein inhibitor is aprotinin.5. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 4 , wherein the concentration of aprotinin is 1 μg/mL to 100 μg/mL.6. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 1 , wherein comprising further adding heparin or heparan sulfate is to the blood to allow initiation of coagulation reaction.7. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 6 , wherein the concentration of heparin is 0.01 to 0.2 unit (U)/mL.8. The method for analyzing thrombogenic capacity or blood coagulation capacity according to claim 6 , wherein the heparin is a low-molecular-weight heparin ...

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Номер записи: 26
11-01-2018 дата публикации

DEVICES AND METHODS FOR BODY FLUID SAMPLING AND ANALYSIS

Номер: US20180008178A1
Автор: Bloom Daniel R., Escutia Raul, Hu Charles, Larkin John F., Reynolds Paul D., Tomasco Michael F., Vivolo Joseph A., Wiard Richard M.
Принадлежит:

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member. 114-. (canceled)15: A body fluid sampling arrangement comprising:a hub comprising a patterned surface, wherein the patterned surface defines a volume;a skin penetration member configured to pierce skin and comprising a bore therethrough, wherein the bore is in fluid communication with the patterned surface; anda quantification member configured to react with a body fluid sample,wherein the hub is configured to collect the body fluid sample in the volume, and when the volume is filled, deliver the body fluid sample to the quantification member.16: The arrangement of claim 15 , wherein the volume is a volume sufficient to provide a measurable result indicative of a property of the body fluid sample.17: The arrangement of claim 16 , wherein the body fluid sample is blood and the property of the body fluid sample is a concentration of glucose.18: The arrangement of claim 15 , wherein the patterned surface is configured to spread the body fluid sample so that it is positioned across a surface of the quantification member prior to contacting the quantification member.19: The arrangement of claim 15 , wherein the bore is centrally positioned relative to the patterned surface and the patterned surface is configured to promote spread of the body fluid sample radially across the patterned surface.20: The arrangement of claim 15 , wherein the patterned surface comprises a groove or a channel configured ...

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Номер записи: 27
10-01-2019 дата публикации

WEARABLE DIGITAL DEVICE FOR PERSONAL HEALTH USE FOR SALIVA, URINE, AND BLOOD TESTING AND MOBILE WRIST WATCH POWERED BY USER BODY

Номер: US20190008463A1
Автор: Xing Zhou Tian, Zhou Andrew H B, Zhou Tiger T G
Принадлежит:

Provided are a wearable personal digital device and related methods. The wearable personal digital device may comprise a processor, a display, biometric sensors, activity tracking sensors, a memory unit, a communication circuit, a housing, an input unit, a projector, a timepiece unit, a haptic touch control actuator, and a band. The processor may be operable to receive data from an external device, provide a notification to a user based on the data, receive a user input, and perform a command selected based on the user input. The communication circuit may be communicatively coupled to the processor and operable to connect to a wireless network and communicate with the external device. The housing may be adapted to enclose the components of the wearable personal digital device. The band may be adapted to attach to the housing and secure the wearable personal digital device on a user body. 1. An Artificial Intelligence (AI) wearable digital device for personal health use for saliva , urine , and blood testing , the device comprising: receive data from an external device;', 'based on the data, provide a notification to a user;', 'receive a user input;', 'perform a command, the command being selected based on the user input;', 'provide a natural language user interface to communicate with the user, the natural language user interface being operable to sense a user voice and provide a response in a natural language to the user;, 'a processor being operable toa near field communication (NFC) unit communicatively coupled to the processor;a display communicatively coupled to the processor, the display including a touchscreen, wherein the display includes a force sensor, wherein the force sensor is operable to sense a touch force applied by the user to the display and calculate coordinates of a touch by the user, and further operable to analyze the touch force, and based on the touch force, select a tap command or a press command based on a predetermined criteria;a memory ...

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Номер записи: 28
10-01-2019 дата публикации

Medical Device Including An Air Evacuation System

Номер: US20190009035A1
Автор: Chee Leong Lum, Peter Douglas, Waheed Abid
Принадлежит: Becton Dickinson and Co

Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

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Номер записи: 29
08-01-2015 дата публикации

Blood Sampling Tube with Integrated Sensor Device

Номер: US20150011847A1
Автор: Hayden Oliver
Принадлежит:

A blood-sampling tube with a first fluid-receiving chamber for receiving a fluid is described, where the first fluid-receiving chamber may be connected to at least one fluid channel that has a sensor device for measuring at least one biochemical function of the fluid passed through the fluid channel, where the measured biochemical function of the fluid may be read out from the sensor device via a data interface of the blood-sampling tube. 1. A blood sampling tube comprising:{'b': '6', 'a first fluid receiving chamber for receiving a fluid, wherein the first fluid receiving chamber () is connected to at least one fluid channel comprising a sensor device for measuring at least one biochemical function of the fluid passed through the fluid channel,'}wherein the at least one measured biochemical function of the fluid is configured to be read out from the sensor device via a data interface of the blood sampling tube.2. The blood sampling tube as claimed in claim 1 , wherein the fluid passed through the fluid channel to a second fluid receiving chamber to which negative pressure can be is applied.3. The blood sampling tube as claimed in claim 2 , wherein the first fluid receiving chamber and the second fluid receiving chamber are separated from the fluid channel by a rupture disk or by a valve.4. The blood sampling tube as claimed in claim 1 , further comprising a needle placed onto the blood sampling tube and configured to withdraw a bodily fluid from an organism.5. The blood sampling tube as claimed claim 1 , wherein an incubation device is provided in the fluid channel for adding reagents to the fluid passed through the fluid channel.6. The blood sampling tube as claimed in claim 5 , wherein the fluid channel has a predetermined fluid channel volume between the incubation device and the sensor device claim 5 , wherein the predetermined fluid channel volume and a flow velocity of the fluid passed through the fluid channel determine an adjustable reaction time of the ...

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Номер записи: 30
19-01-2017 дата публикации

MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF

Номер: US20170014064A1
Автор: Burd Tammy, Frenzel Gary, Gibbons Ian, Holmes Elizabeth A., Nugent Anthony Joseph
Принадлежит:

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. 158-. (canceled)59. A method of measuring a volume of a sample of a biological fluid , comprising:a. reacting a known quantity of a control analyte in said sample with a reagent to yield a detectable signal indicative of the quantity of the control analyte; andb. comparing said detectable signal with an expected detectable signal, wherein the expected signal is indicative of an expected volume of the sample, and wherein said comparison provides a measurement of said volume of said sample being measured.60. The method of claim 59 , wherein the control analyte is normally not present in said sample in a detectable amount.61. The method of further comprising verifying the volume of said sample when the measurement of the volume of the sample is within about 50% of the expected volume of the sample.62. The method of further comprising:a. reacting a bodily fluid sample containing a target analyte with a reagent to yield a detectable signal indicative of the target analyte; andb. measuring the quantity of the target analyte in the bodily fluid sample based on of said detectable signal indicative of the target analyte and the measurement of said volume of said liquid sample.63. The method of claim 59 , wherein the liquid sample and the bodily fluid sample are the same sample.64. The method of claim 59 , wherein the control analyte does not react with the target analyte in the bodily fluid sample.65. The method of claim 59 , wherein the liquid sample and the bodily fluid sample are different liquid samples.66. The method of claim 59 , wherein the control analyte is selected from the group consisting of: albumin claim 59 , fluorescein ...

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Номер записи: 31
21-01-2016 дата публикации

Biological Sample Containment System and Label

Номер: US20160016165A1
Автор: Bo Yon Lillian Yoo, Craig Owen Russ, Eric John PROVENCHER
Принадлежит: Becton Dickinson and Co

A biological sample containment system and a label for a container that includes a first layer having a first readable information portion and a second layer removably attached to the first layer, the second layer having a second readable information portion, is disclosed. In one embodiment, the first layer and the second layer of the label are both formed of a thermosensitive material. In one embodiment, at least a part of the first readable information portion is identical to at least a part of the second readable information portion. The label of the present disclosure allows a portion of the label having readable information to be removed and adhered to a patient record, for example, while a portion of the label having identical readable information remains on the container.

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Номер записи: 32
16-01-2020 дата публикации

CASSETTE FOR BLOOD SAMPLE MEASUREMENT COLLECTION AND STORAGE

Номер: US20200015725A1
Автор: Fink Catherine, Johnson Brandon T., Kopitzke Keith
Принадлежит:

A device uses push-initiated force to collect, meter, filter and store a blood sample. In one implementation, the push-initiated force may be provided in a cassette-type housing that also collects, meters, filters and/or stores the blood sample. 1. A blood sample collection device comprising:a housing;a collection well;a metering component coupled to the collection well for collecting a metered portion of the blood sample;absorptive media, disposed in a frame, adjacent to and in fluid communication with the metering component; anda movable member engaging an upper region of the collection well, and providing push-driven mechanical force to initiate collection of a blood sample onto the absorptive media.2. The device of wherein a breakable tab is disposed between the movable member and the frame supporting the absorptive media.3. The device of wherein a hinged cover is disposed over the collection well.4. The device of wherein the the metering component is disposed on on a substrate composed of two components that separate upon application of the mechanical force.5. The device of wherein the well and metering component form a subassembly that is disposed adjacent the frame containing the absorbtive media.6. The device of additionally wherein the absorbtive media is a microfluidic separation media for separating plasma from whole blood in the blood sample.7. The device of additionally comprising one or more supports for supporting the microfluidic separation media within the housing.8. The device of additionally comprising:an anticoagulant disposed within the metering component.9. The device of wherein the absorptive media is removable from the housing after application of the mechanical force.10. A device for collecting a fluid sample comprising:a sample port cover,a top housing,a fluid collection assembly,a bottom housing, anda frame assembly, whereinthe fluid collection assembly includes a sample port, an exit end, and one or more microfluidic channels disposed on ...

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Номер записи: 33
16-01-2020 дата публикации

RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS

Номер: US20200015751A9
Автор: Bernstein Howard, Chickering, Davis Shawn, Haghgooie Ramin, III Donald E., Levinson Douglas A., Michelman Mark
Принадлежит: Seventh Sense Biosystems, Inc.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. 1148-. (canceled)149. A device for receiving blood from a subject , the device comprising:a plurality of skin insertion objects for insertion into the skin of a subject, having a pre-deployed position and a deployed position; anda reversibly deformable structure, operably linkable to the plurality of skin insertion objects, the reversibly deformable structure switchable from a first position, through an actuation energy barrier, to a second position, wherein the first position is associated with the pre-deployed position of the skin insertion objects, and the second position is associated with the deployed position of the skin ...

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Номер записи: 34
21-01-2021 дата публикации

FLUID COLLECTION DEVICE AND RELATED METHODS

Номер: US20210015413A1
Автор: Dirckx Matthew, Singh Hardeep, Taylor Jason
Принадлежит: OPKO Diagnostics, LLC

Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices. 1. An article for introducing a fluid into a fluidic system , comprising:a fluid collection region comprising an edge, a sidewall, and a bottom portion; anda receiving channel integrally connected to and in fluidic communication with the fluid collection region, wherein the receiving channel includes a concave portion adapted and arranged to receive a fluidic channel.2. An article as in claim 1 , wherein the edge is a curved edge.3. An article as in claim 1 , wherein the edge is tapered.4. An article as in claim 1 , wherein the receiving channel is adapted and arranged to receive a fluidic channel to allow fluid communication between the fluidic channel and the fluid collection region.5. An article as in claim 4 , wherein the fluidic channel is a part of a fluidic connector.6. A device for introducing a fluid into a fluidic system claim 4 , comprising:a fluidic connector comprising a fluidic channel that includes a fluid path having a fluid path inlet and a fluid path outlet, wherein the fluidic connector is adapted and arranged ...

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Номер записи: 35
21-01-2021 дата публикации

SYSTEM AND METHOD FOR BLOOD SAMPLE COLLECTION AND PROCESSING

Номер: US20210015414A1
Автор: ADAIR Fiona S., HECKEL Dirk, YANG David L.
Принадлежит:

Blood sample collection and processing system () using a tube () and a holder () is described herein. The tube () includes a plasma separation system () for converting a whole blood sample () into a plasma sample without using centrifugation. The plasma separation system () may comprise a filtration system such as a hollow fiber element (). The tube () is thereafter placed in the holder () for analysis regarding the plasma. The results of the analysis may be displayed to the user via a display screen () to allow the user to determine whether the sample is sufficient for further use. Inasmuch as the analysis system () performs a rapid analysis of the plasma sample, the patient may still be present or in close proximity and if the sample is insufficient, the healthcare provider can take another whole blood sample (), counsel the client regarding the blood sample (), or examine the patient further. 1. A collection system comprising:(a) a tube; and(b) a holder, wherein the holder is configured to receive the tube therein.2. The collection system of claim 1 , wherein the tube comprises a plasma separation system.3. The collection system of claim 2 , wherein the plasma separation system comprises a filtration system.4. The collection system of claim 3 , wherein the filtration system comprises a hollow fiber element.5. The collection system of claim 4 , wherein the hollow fiber element comprises:(a) a filter wall, wherein the filter wall is configured to allow plasma to pass therethrough; and(b) an interior defined by the filter wall, wherein the interior is configured to received whole blood therein.6. The collection system of claim 5 , further comprising a pressure system configured to force whole blood through the filter wall.7. The collection system of claim 1 , wherein the tube defines a collection chamber.8. The collection system of claim 7 , wherein the collection chamber defines an analysis pocket therein.9. The collection system of claim 1 , wherein the holder ...

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Номер записи: 36
21-01-2021 дата публикации

Plasma Separation Device

Номер: US20210018487A1
Автор: Brian Weinberg, Daniel Braun, Timothy Murray
Принадлежит: Vivebio Scientific LLC

Devices and methods are provided that permit efficient and selective separation of liquid biological specimens into at least two constituent components to facilitate subsequent quantitative and qualitative analysis on at least one analyte of interest in at least one of the components. The devices generally include one or more sample deposition regions supported on a base. Each sample deposition region includes a separation membrane for separating the liquid biological specimen into two different fractions. The first fraction is trapped by the separation membrane while the second fraction passes through the separation membrane and into a respective collection membrane. The separation and collection membranes are easily separable from the devices and can be utilized for further processing and analysis.

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Номер записи: 37
28-01-2016 дата публикации

DEVICE FOR TAKING A LIQUID SAMPLE BY CAPILLARITY AND ASSOCIATED ANALYSIS METHOD

Номер: US20160022189A1
Автор: Berthier Jean, POHER Vincent, Pouteau Patrick
Принадлежит: Commissariat A L'Energie Atomique Et Aux Energies Alternatives

A device for taking a sample of liquid by capillarity, including a channel for flow of the liquid delimited by two internal walls of the device between which a channel bottom extends, the distance separating the two internal walls decreasing in the direction of the channel bottom, the channel extending between a first collecting end, open onto outside of the device and configured to receive the liquid, and a second end, to enable the liquid to flow by capillarity along the channel bottom from the first end towards the second end. The channel includes, at the second end, a blocking structure to block the flow of liquid in the channel from the first end towards the second end. 121-. (canceled)22. A device for taking a sample of liquid by capillarity , comprising:a channel for flow of the liquid delimited by two internal walls of the device between which a channel bottom extends, a distance separating the two internal walls decreasing in a direction of the channel bottom,the channel extending between a first collecting end, open onto outside of the device and configured to receive the liquid, and a second end, to enable the liquid to flow by capillarity along the channel bottom from the first end towards the second end,the channel comprising, at the second end, a blocking means configured to block the flow of liquid in the channel from the first end towards the second end.23. A device according to claim 22 , wherein the channel comprises blocking means in a form of a closure wall of the channel.24. A device according to claim 22 , wherein the channel comprises the blocking means in a form of at least one blocking ridge formed on at least one internal wall of the device claim 22 , allowing a broadening of at least part of the channel.25. A device according to claim 22 , wherein the channel comprises the blocking means in a form of a coating made locally hydrophobic to prevent the flow of liquid.26. A device according to claim 22 , wherein the channel comprises the ...

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Номер записи: 38
26-01-2017 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE TRANSPORT

Номер: US20170020425A1
Автор: Chen Michael, Holmes Elizabeth A., Lui Clarissa, Young Daniel
Принадлежит:

Bodily fluid sample transport systems, devices, and method are provided. In at least one embodiment described herein, methods are provided for the physical transport of small volumes of bodily fluid in liquid form from one location to another location. By way of nonlimiting example, the samples are collected in liquid form at a collection site, transported in liquid form, and arrive at an analysis site in liquid form. In many embodiments, the liquid form during transport is not held in a porous matrix, wicking material, webbing, or similar material that prevents sample for being extracted in liquid form at the destination site. In one embodiment, small volume of sample in each sample vessel is in the range of about 1 ml to about 1 microliter. 169-. (canceled)70. A method comprising:collecting a bodily fluid sample on a surface of a subject, wherein the collected sample is stored in one or more sample vessels;providing a transport container to house at least two or more sample vessels, wherein the vessels are arranged in a two-dimensional array configuration in the transport container;arranging to have the sample vessels shipped in the transport container from a first location to a second location,wherein each of the sample vessels arrives at the second location holding a majority of its bodily fluid sample in a non-wicked, non-matrixed form that is removable from the sample vessels in liquid form and wherein the amount of sample in each of the sample vessels does not exceed about 2 ml; andscanning information storage units on substantially all of the sample vessels, wherein the scanning occurs while the sample vessels remain in the two-dimensional array configuration at the second location.71. The method of wherein collecting comprises making at least one puncture on the subject to release the bodily fluid claim 70 , wherein the puncture is not a venipuncture.72. The method of wherein collecting comprises using at least one lancet to make at least one puncture on ...

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Номер записи: 39
26-01-2017 дата публикации

Method and apparatus for acquiring blood for testing

Номер: US20170023446A1
Автор: Gijsbertus G. Rietveld, Monika M. Kansal, Stuart Kushon
Принадлежит: NEOTERYX LLC

A blood sampling device is provided having holder with a manipulating end and an absorbent probe on the opposing end. The probe is made of pyrolyzed porous carbon sized to directly absorb a predetermined volume of liquid, preferably biological fluid, in a predetermined amount of time. Shapes for absorbent probes of differing materials are provided.

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Номер записи: 40
26-01-2017 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION, TRANSPORT, AND HANDLING

Номер: US20170023546A1
Автор: Anekal Samartha, Chen Michael, Holmes Elizabeth A., Lui Clarissa, Young Daniel
Принадлежит:

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. 1. A method for use with a bodily fluid sample from a subject , the method comprising:shipping a plurality of sample containers from a first location to a second location, wherein each of said sample containers contains about 500 μL or less but greater than about 30 μL of the bodily fluid sample, wherein interior volume of each of the sample containers is about 600 μL or less,subjecting the bodily fluid sample to a first accelerated sedimentation force of at least about 1400 g or greater to form a first processed sample;shipping the first processed sample from a first location to a second location; andsubjecting the first processed sample at the second location to a second accelerated sedimentation force of greater than about 10 g but less than about 500 g.2. (canceled)3. The method of wherein the first processed sample contains a heparin-based anti-coagulant.4. The method of wherein the first processed sample contains a plasma portion separated by a separation gel from a formed-blood component portion.5. The method of wherein the second processed sample does not force electrolytes though the separation gel from the formed-blood component portion to the plasma portion.6. The method of wherein the second processed sample does not force liquid though the separation gel from the formed-blood component portion to the plasma portion.7. The method of wherein the first accelerated sedimentation force is provided through centrifugation.8. The method of wherein the second accelerated sedimentation force is provided through centrifugation.9. The method of wherein a plurality of samples are shipped from a ...

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Номер записи: 41
28-01-2021 дата публикации

SAMPLING DEVICE INTERFACES

Номер: US20210022681A1
Автор: Bernstein Howard, Chickering, Davis Shawn, Haghgooie Ramin, III Donald E., Levinson Douglas A.
Принадлежит: Seventh Sense Biosystems, Inc.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. 187-. (canceled)88. A device for withdrawing blood from a subject , the device comprising:a recess comprising a fluid transporter, the fluid transporter comprising one or more needles;a detachable portion containing a storage chamber ...

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Номер записи: 42
24-01-2019 дата публикации

LOW-PRESSURE PACKAGING FOR FLUID DEVICES

Номер: US20190023473A1
Автор: Schott Kevin
Принадлежит: Seventh Sense Biosystems, Inc.

The present invention generally relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin, including packaging associated with such systems. Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers, e.g., having an internal pressure less than atmospheric pressure. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein. In some embodiments, the pressure of the environment may be the same as or less than that of vacuum chambers contained within the device. Other aspects of the invention are generally directed to methods of creating such devices, techniques for using such devices, kits involving such devices, and the like. 135-. (canceled)36. An article , comprising:{'sub': 'absolute', 'a package containing an environment having a pressure that is less than about 710 mmHg, the environment surrounding a device comprising one or more microneedles and a vacuum chamber having an internal pressure less than atmospheric pressure.'}37. The article of claim 36 , wherein at least a portion of the package is manually deformable.38. The article of claim 36 , wherein at least a portion of the package is rigid.39. The article of claim 36 , wherein the device further ...

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Номер записи: 43
29-01-2015 дата публикации

Stabilising and analysing fatty acids in a biological sample stored on solid media

Номер: US20150027208A1
Автор: Liu Ge, Robert Gibson
Принадлежит: ADELAIDE RESEARCH AND INNOVATION PTY LTD

The present invention relates to a method for stabilising fatty acids present in a sample such as bodily fluids. The present invention further relates to a solid medium which is capable of stabilising fatty acids applied thereto, and a method for preparing same. The present invention further relates to a method for determining the fatty acid composition of a sample.

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Номер записи: 44
24-01-2019 дата публикации

Blood and Marrow Draw Processing Devices and Methods

Номер: US20190025162A1
Автор: Centeno Christopher J., Dregalla Ryan, LEACH Brian, Reischling Patrick
Принадлежит:

Apparatus, systems and methods for processing a blood sample. One embodiment includes an isolation container having at least one sidewall defining an interior volume. The interior volume includes a medial reservoir in fluid communication with proximal and distal reservoirs. The diameter of the medial reservoir is less than the diameter of the proximal and distal reservoirs. Therefore, the isolation container has an interior volume which is roughly hour-glass shaped with the medial reservoir being a substantially narrowed portion or channel between two wider portions. The isolation container is configured such that the buffy coat layer of fractionated blood will be located within, or may be manipulated to be with the medial reservoir. 1. An isolation container for processing a blood sample comprising:a proximal reservoir having a diameter;a transparent medial reservoir in fluid communication with the proximal reservoir, the transparent medial reservoir having a diameter which is less than the diameter of the proximal reservoir;a distal reservoir positioned opposite the transparent medial reservoir from the proximal reservoir, the distal reservoir being in fluid communication with the transparent medial reservoir, the distal reservoir having a diameter which is greater than the diameter of the transparent medial reservoir; andan adjustable sealing element in sealing engagement with a portion of a side wall of the distal reservoir, said adjustable sealing element providing for an increase or a decrease of a volume within the distal reservoir.2. The isolation container for processing a blood sample of further comprising a handle engaged with the sealing element.3. The isolation container for processing a blood sample of further comprising a threaded connection between the handle and the sealing element.4. The isolation container for processing a blood sample of further comprising a removable cap closing an opening into the proximal reservoir.5. The isolation container ...

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Номер записи: 45
24-01-2019 дата публикации

Test Sensor Cartridges And Sensor-Dispensing Instruments

Номер: US20190025278A1
Автор: Creaven John P., Reynolds Jeffery S.
Принадлежит:

The cartridge comprises a housing, a plurality of test sensors, a mechanical mechanism, and a pusher assembly. The housing forms at least one opening therethrough. The plurality of test sensors is stacked in the housing. The plurality of test sensors is adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the plurality of test sensors in a first direction. One of the plurality of test sensors is positioned for extraction from the cartridge. The pusher assembly is adapted to push one of the plurality of test sensors from the cartridge. The pusher assembly includes a ferromagnetic material or a magnet. 1187-. (canceled)188. A cartridge comprising:a housing forming at least one opening therethrough;a plurality of test sensors being stacked in the housing, the plurality of test sensors being adapted to assist in testing at least one analyte;a mechanical mechanism being adapted to urge the plurality of test sensors in a first direction, one of the plurality of test sensors being positioned for extraction from the cartridge; anda sliding pusher lid assembly including a flexible pusher tab, the flexible pusher tab being adapted to contact and push one of the plurality of test sensors from the housing and at least partially through the opening, the flexible pusher tab extending generally outwardly and generally downwardly from the remainder of the sliding pusher lid assembly,wherein in the closed position, the sliding pusher lid assembly is adapted to assist in sealing the cartridge.189. The cartridge of claim 188 , wherein the sliding pusher lid assembly further includes a pusher grip to assist in the user in gripping and sliding the pusher lid assembly.190. The cartridge of claim 188 , further including a reference surface that is adapted to contact the plurality of test sensors one at a time and assist in removing the plurality of test sensors one at a time.191. The cartridge of claim 188 , wherein the flexible pusher tab ...

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Номер записи: 46
04-02-2016 дата публикации

Analyte sensors, systems, testing apparatus and manufacturing methods

Номер: US20160029935A1
Автор: Jiangfeng Fei, Narasinha Parasnis, Serban Peteu, Swetha Chinnayelka, Yuan Wang
Принадлежит: Ascensia Diabetes Care Holdings AG

In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include one or more conductors received in a hollow portion of a hollow member. The first conductor may be made, at least in part, of a semiconductor material and an active region may be provided in contact with at least the first conductor. The analyte sensor may, in one aspect, include a lancet and an integrated sensor. Manufacturing methods and apparatus and systems utilizing the analyte sensors are provided, as are numerous other aspects.

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Номер записи: 47
04-02-2016 дата публикации

DEVICE FOR SEPARATION AND COLLECTION OF PLASMA

Номер: US20160029936A1
Автор: Finehout Erin Jean, Griffin Weston Blaine, Kvam Erik Leeming, Mao Ying
Принадлежит:

A method for separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor. The method comprising placing a tourniquet on one of the digits of the donor's finger to apply pressure, lancing the digit to create an incision in the digit, and collecting blood from the incision from the incision site. The collected blood is placed on a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the membranes. A kit and instructions for carrying out the method is also provided. 1. A method of separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor , the method comprising;placing a tourniquet on one of the digits of the donor's finger to apply pressure;lancing the digit to create an incision in the digitoptionally removing the first blood immediately after lancing while still applying pressurecollecting blood from the incision by holding a capillary tube against a blood drop formed from the incision site;dispersing the collected blood from the capillary tube onto a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the said membranes.2. The method of where the substrate comprises;an inner flexure formed from a plurality of first slots in the substrate, disposed proximate to a first peripheral portion of the substrate; andan outer flexure formed from a plurality of second slots in the substrate, disposed surrounding at least a portion of the plurality of first slots;wherein a distal end of the separation membrane is disposed under the outer flexure, wherein a proximal end of the collection membrane is disposed under at least one of the outer flexure and ...

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Номер записи: 48
04-02-2016 дата публикации

FLUID EXTRACTION AND DRUG DELIVERY SYSTEM AND METHODS USING MICRONEEDLES

Номер: US20160029937A1
Автор: SIA Samuel K., TEJAVIBULYA Nalin
Принадлежит:

Devices systems and methods for fluid extraction and delivery to human or animal hosts are described. In embodiments, microneedles are employed to provide low infection risk and painless access to and administration of fluids. The disclosed embodiments address, among others, issues of cost, portability, ease of use in remote settings including use by untrained personnel, and others. 1. A device for sampling fluid , comprising:a first member having an array of microneedles and, coplanar therewith, an array of detectors, the optical detectors being adapted to detect hemoglobin in the body of a human or animal subject;a controller configured to receive signals from the detectors and to calculate a position for insertion of an extraction needle responsively to the detector signals, either by itself or by conveying data to a remote computation device;a drive motor arranged to move the first member to position a selected one of the microneedles responsively to said position for insertion;a mechanism constructed to translate the selected one of the microneedles along an axis thereof such that the selected one of microneedles can be inserted in a human or animal subject.2. The device of claim 1 , further comprising a housing enclosing at least the first member and fitted with a retaining strap to permit the housing to be strapped to a human or animal subject.3. The device of claim 1 , wherein the first member is fitted with an extraction motor arranged to move the selected one of the microneedles along an axis thereof.4. The device of claim 1 , further comprising a second member claim 1 , movable relative to the first claim 1 , and carrying an extraction motor arranged to move the selected one of the microneedles along an axis thereof.5. The device of claim 3 , wherein the extraction motor is one of a linear motor and a thermoelectric motor.6. The device of claim 1 , where in the first member includes a network of channels and a sample chamber held under vacuum.7. The ...

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Номер записи: 49
31-01-2019 дата публикации

BLOOD AND BIOLOGICAL SAMPLE COLLECTION DEVICE AND METHOD

Номер: US20190029581A1
Автор: Mink Ronald William, Piacentini Stephen Carl, Smith Paul Robert
Принадлежит: Sedia Biosciences Corporation

Specially designed collection strips and their processing. By using specially designed collection strips, having a backer and one or more absorbent pads, in conjunction with a unique processing method, the processes of analyzing biological samples such as blood, or the like, may be done efficiency with the elimination of cross contamination risk. Identification of the sample stays with the sample throughout the process as it resides on the collection strip. The strip absorbs a known volume. The sample with identification is placed directly in an elution solution, without mechanically separating the sample from its identification information. Elimination of the need for mechanical separation tends to reduce cross contamination, as well as reducing sample processing time. 1. A blood collection device that does not require punching , or folding to obtain a sample for processing comprising:a flat rectangular elongated backer having a first end and a second end;a planar label area disposed on the first end upon which identifying information of a collected sample is recorded; anda separate absorbent pad attached at the second end of the flat rectangular elongate backer that does not require punching to obtain a sample whereby a blood sample is applied to the absorbent pad and dried for later testing, the construction of the blood collection device not requiring a folding, a punching out, or detachment of a portion of the blood collection device containing the blood sample, and whereby the identifying information of the collected sample stays affixed to the sample during processing of the sample.2. The blood collection device of claim 1 , in which the absorbent pad is cellulose.3. The blood collection device of claim 1 , in which the absorbent pad is polyester.4. The blood collection device of claim 1 , in which the absorbent pad is glass fiber.5. The blood collection device of claim 1 , in which the absorbent pad is treated with a detergent.6. The blood collection device ...

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Номер записи: 50
17-02-2022 дата публикации

Sample handling device

Номер: US20220048027A1
Автор: Ernest M. Bate, Mika Laitinen, Tom HAYDON
Принадлежит: MAGNASENSE TECHNOLOGIES OY

A sample handling device includes a reservoir for holding a fluid medium. A channel system used in connection with the reservoir includes a dilution portion for a sample to be analyzed with a measurement device. The sample is arranged to be transferred from the dilution portion to the measurement device by the fluid medium. A set of capillary channels in the dilution portion is arranged to be filled by capillary action to collect an established quantity of the sample to be diluted by the fluid medium. A pump transfers the fluid medium from the reservoir to the channel system. The pump includes at least one plunger, a seal separating the reservoir and the channel system and a delivery system of potential energy including a compressible element configured to provide repeatable transfer of the fluid medium from the reservoir to the channel system.

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Номер записи: 51
30-01-2020 дата публикации

HAND-HELD APPLICATOR

Номер: US20200029878A1
Автор: Gygax Daniel, NAEF Gregor, STEINER Lukas, Weber Jakob, WERNLI Cédric
Принадлежит:

A hand-held applicator () for collecting, mixing, diluting and discharging a sample liquid, comprising a main body () having an inlet-aperture (), an outlet-aperture () and a chamber () for storing a liquid solution, wherein the chamber is connected to the inlet-aperture and the outlet-aperture, a lid () for covering the inlet-aperture and a tube (), moveably supported in the inlet-aperture when the lid is covering the upper portion of the main body, wherein the tube () is moveable between a predetermined position outside the chamber and a position, in which the tube is at least partly located in the chamber. 117-. (canceled)1810. A hand-held applicator () for collecting , mixing , diluting and discharging a sample liquid , comprising{'b': 20', '24', '26', '22', '22', '24', '26, 'a main body () having an inlet-aperture (), an outlet-aperture () and a chamber () for storing a liquid solution, wherein the chamber () is connected to the inlet-aperture () and the outlet-aperture ();'}{'b': 12', '24, 'a lid () for covering the inlet-aperture (); and'}{'b': 40', '24', '12', '20', '40', '22', '40', '22, 'a tube (), moveably supported in the inlet-aperture () when the lid () is covering the upper portion of the main body (), wherein the tube () is moveable between a predetermined position outside the chamber () and a position, in which the tube () is at least partly located in the chamber ().'}19292222. The hand-held applicator according to claim 18 , wherein an outlet-opening () of the chamber () is provided on a protrusion on the bottom of the chamber ().2029223620. The hand-held applicator according to claim 18 , wherein an outlet-opening () of the chamber () is provided on top of a moveable plunger () that is accommodated in a bottom portion of the main body ().214024. The hand-held applicator according to claim 18 , wherein the tube () is supported by a plunger that is movably accommodated in the inlet-aperture ().2222. The hand-held applicator according to claim 18 , ...

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Номер записи: 52
04-02-2021 дата публикации

BLOOD SAMPLE GUIDING INSTRUMENT AND BLOOD TEST KIT

Номер: US20210030346A1
Автор: Noguchi Osamu, Sugimoto Shinya
Принадлежит: FUJIFILM Corporation

Provided are a blood sample guiding instrument and a blood test kit which enable blood ejected from a finger to be guided to a storing instrument. A blood sample guiding instrument used in a blood test kit includes a cylindrical body in which a first opening and a second opening communicating with the first opening are defined and which comes into contact with a finger; and a clamping portion that is attached to an outer circumferential surface of the cylindrical body, clamps a finger, and presses the cylindrical body against the finger. 1. A blood sample guiding instrument used in a blood test kit , the blood sample guiding instrument comprising:a cylindrical body in which a first opening and a second opening communicating with the first opening are defined and which comes into contact with a finger; anda clamping portion that is attached to an outer circumferential surface of the cylindrical body, clamps a finger, and presses the cylindrical body against the finger,wherein a shape of a part of the cylindrical body which comes into contact with the finger is a curved shape protruding toward a finger side in a top view.2. The blood sample guiding instrument according to claim 1 , wherein the first opening of the cylindrical body is larger than the second opening claim 1 , and at least a part of an inner circumferential surface of the cylindrical body forms a tapered surface.3. The blood sample guiding instrument according to claim 1 , wherein the clamping portion includes a support member claim 1 , and at least two binding members that are disposed to be spaced from each other.4. The blood sample guiding instrument according to claim 3 , wherein the binding member adjusts a clamping force for the finger.5. The blood sample guiding instrument according to claim 3 , wherein the binding member is provided at a positioning portion provided on the outer circumferential surface of the cylindrical body.6. The blood sample guiding instrument according to claim 1 , wherein ...

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Номер записи: 53
04-02-2021 дата публикации

Integrated Device for Self-Collecting and Automated Pre-Processing of Biological Fluids

Номер: US20210030347A1
Автор: GU Jian, Nordquist Alan, Zenhausern Frederic
Принадлежит:

Provided is an integrated sample collection device for self-collection and analytical pre-processing of a fluid sample, such as a blood sample from a user. A housing is configured to be held by a user, such as a single hand of a user. A contact-activated penetrating member is disposed at least partially in the housing and configured to penetrate skin. A capillary tube is disposed at least partially in the housing and configured to collect blood released by the penetrating member that penetrates the skin. A vacuum-assisted blood collection container can be fluidically connected to the capillary tube for receiving at least a portion of the collected blood. One or more stabilizing/pre-processing agents are provided for stabilizing/pre-processing collected blood in the capillary tube, the vacuum-assisted blood storage container, or both. 1. An integrated sample collection device for self-collection and analytical pre-processing of a biological fluid sample from a user comprising:a housing configured to be held by a user;a contact-activated penetrating member disposed at least partially in the housing and configured to penetrate skin;a capillary tube at least partially disposed in the housing and configured to collect blood released from the penetrating member that penetrates the skin;a vacuum-assisted blood collection container fluidically connected to the capillary tube for receiving at least a portion of the collected blood; andone or more stabilizing and/or pre-processing agents for initiating an analytical pre-processing of the collected blood in the capillary tube, the vacuum-assisted blood collection container, or both.2. The integrated sample collection device of that is a multiple sample collection device further comprising:a plurality of capillary tubes; anda plurality of blood collection containers, with each individual capillary tube fluidically connected to a unique individual blood collection container.3. The integrated sample collection device of claim 1 , ...

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Номер записи: 54
09-02-2017 дата публикации

Biological Fluid Collection Device and Biological Fluid Collection System

Номер: US20170035337A1
Автор: Newby C. Mark, Wilkinson Bradley M.
Принадлежит:

A biological fluid collection device that is adapted to receive a blood sample is disclosed. The biological fluid collection device includes a housing, a puncturing element transitionable between a pre-actuated position wherein the puncturing element is retained within the housing and a puncturing position wherein at least a portion of the puncturing element extends through the housing, and a cartridge removably connectable to a portion of the housing. After collecting a blood sample, the cartridge is removable from the housing and the cartridge is able to transfer the blood sample to a point-of-care testing device. The biological fluid collection device provides a closed system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. 1. A biological fluid collection device , comprising:a housing having a receiving port and an inlet port, the inlet port defining a housing flow channel therein, the housing flow channel in fluid communication with the inlet port;a puncturing element at least partially disposed within the housing and transitionable between a pre-actuated position wherein the puncturing element is retained within the housing and a puncturing position wherein at least a portion of the puncturing element extends through the inlet port of the housing for establishing fluid communication with the housing flow channel; anda cartridge removably connectable to the receiving port of the housing, the cartridge defining a cartridge flow channel therein,wherein, with the cartridge connected to the housing, the cartridge flow channel is in fluid communication with the housing flow channel, andwherein, with the cartridge disconnected from the housing, the cartridge flow channel is sealed.2. The biological fluid collection device of claim 1 , further comprising a sample stabilizer disposed within a portion of the cartridge flow channel.3. The biological fluid collection device of claim 1 , wherein the housing ...

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Номер записи: 55
09-02-2017 дата публикации

METHOD AND APPARATUS FOR BLOOD COLLECTION

Номер: US20170035338A1
Автор: Cembrowski George S.
Принадлежит:

Blood collection apparatus includes a blood collection container and a mix detection unit operatively coupled to the blood collection container. The mix detection unit includes a device to produce a data signal indicative of the extent to which the blood collection container is moved in a manner to promote mixing of blood collected into the container and an anti-coagulant also present in the container. A method described herein provides for filling a blood collection container with blood, inverting the blood collection container by hand to mix the blood with an anti-coagulant, and viewing or listening to an indication generated by a mix detection device attached to the blood collection container, wherein the indication provides information about the appropriate amount of mixing for the blood. 1. (canceled)2. A method comprising:a phlebotomist extracting blood from a patient;the phlebotomist adding the extracted blood to a blood collection container;the phlebotomist repeatedly inverting the blood collection container to mix the blood with an anti-coagulant or pro-coagulant in the blood collection container;a mix detection device counting, using a counting circuit, the number of inversions performed by the phlebotomist; andthe phlebotomist listening to an indication generated by a speaker communicatively coupled to the mix detection device or viewing the indication on a display communicatively coupled to the mixed detection device, wherein the indication provides information indicating the number of counted inversions.3. The method of claim 2 , wherein the phlebotomist viewing or listening to the indication generated by the mix detection device includes the phlebotomist listening for an audible indication from the mix detection device that the blood and the anti-coagulant or pro-coagulant in the blood collection container is sufficiently mixed with the blood.4. The method of further comprising the phlebotomist viewing a visual indication generated by the display of ...

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Номер записи: 56
11-02-2016 дата публикации

Blood sampling device

Номер: US20160038067A1
Автор: Bryan G. Davis, Jonathan Karl Burkholz, Minh Quang Hoang, Yiping Ma
Принадлежит: Becton Dickinson and Co

A blood sampling device useful for collecting a blood sample from a separate vascular access device is described herein. The blood sampling device includes a body shaped and sized for partial insertion into a separate vascular access device. The body includes a reservoir defined within the body, which has an internal volume sufficient to contain enough blood for use in a diagnostic blood test. The body also includes a gas permeable vent disposed on the body, in which the gas permeable vent is in gaseous communication with the reservoir. When connected to a separate vascular access device the blood sampling device collects a blood sample as blood flows into the reservoir from the separate vascular access device and as gases pass out the reservoir via the gas permeable vent.

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Номер записи: 57
24-02-2022 дата публикации

SYRINGE APPARATUS AND METHODS

Номер: US20220054063A1
Автор: Samproni Jennifer
Принадлежит: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Disclosed is a syringe apparatus. Syringe apparatus has a barrel including an inner surface, an open end, and an inlet end; a plunger including a plunger head received in slidable sealing contact with the inner surface of the barrel and forming a reservoir therein; and an extensible member, optionally including an additive, is contained in the reservoir. Extensible member can be coupled between the inlet end and the plunger head and is extensible in length L as a bio-liquid (e.g., whole blood) is drawn into the reservoir. Methods of mixing or adding an additive such as an anticoagulant, coagulant, or marker, to a bio-liquid are provided, as are other aspects. 1. A syringe apparatus , comprising:a barrel including an inner surface, an open end, and an inlet end;a plunger including a plunger head received in slidable sealing contact with the inner surface of the barrel and forming a reservoir therein; andan extensible additive-disassociating member contained in the reservoir.2. The syringe apparatus of claim 1 , wherein the extensible additive-disassociating member is coupled between the plunger head and the inlet end.3. The syringe apparatus of claim 2 , wherein a first end of the extensible additive-disassociating member is attached to the plunger head.4. The syringe apparatus of claim 2 , wherein a second end of the extensible additive-disassociating member is attached to the inlet end.5. The syringe apparatus of claim 1 , wherein the extensible additive-disassociating member comprises an additive configured to retain or change a state or property of a bio-liquid specimen drawn into the reservoir.6. The syringe apparatus of claim 5 , wherein the extensible additive-disassociating member comprises an additive coated on a surface thereof.7. The syringe apparatus of claim 5 , wherein the extensible additive-disassociating member comprises an additive absorbed into an absorbent matrix thereof.8. The syringe apparatus of claim 5 , wherein the additive is selected from a ...

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Номер записи: 58
18-02-2016 дата публикации

Dried blood spot collection device

Номер: US20160045148A1
Автор: Amira Al-Uzri, Andrew Chitty, Asa Weiss, Dennis Koop, Ethan Vella, Gerold Firl, Lisa BLEYLE, Robert W. Beauchamp
Принадлежит: Oregon Health Science University, Simplexity Product Development Inc

Apparatuses and methods for dried blood spot (DBS) sample collection are disclosed. A dried blood spot sampling device is configured to deliver blood through a passage to an absorbent disk in the device and control an amount of blood saturating the absorbent disk. The sampling device may include a manually actuatable component adjustable between a first position, in which an outlet of the passage is not in physical contact with the absorbent disk, and a second position, in which the outlet of the passage is in physical contact with the absorbent disk.

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Номер записи: 59
16-02-2017 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION

Номер: US20170042460A1
Автор: Burd Tammy, Chen Michael, Holmes Elizabeth A., Ko Pey-Jiun, Lath Adrit, McHale Patricia, Roy Joy
Принадлежит:

Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container. 1. A device for collecting a bodily fluid sample , the device comprising:a first portion comprising a plurality of capillary sample collection channels;a second portion comprising a plurality of sample containers for receiving the bodily fluid sample collected in the sample collection channels, wherein the sample containers have gas permeable and penetration re-sealable enclosure, wherein the gas permeable closure allows for sample to be transferred from the capillary channels to the containers without having to use a separate motive force.2. A device for collecting a bodily fluid sample , the device comprising:a first portion comprising a plurality of capillary sample collection channels;a second portion comprising a plurality of sample containers for receiving the bodily fluid sample collected in the sample collection channels, wherein the sample containers have gas permeable and penetration re-sealable enclosure, wherein the gas permeable closure allows for sample to be transferred from the capillary channels to the containers without having to use a separate motive force, wherein a flow facilitator to provide a favorable pathway to from the channels into the container.369-. (canceled)70. The device of claim 1 , wherein an ...

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Номер записи: 60
06-02-2020 дата публикации

SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS

Номер: US20200041487A1
Автор: Greenquist Alfred, Sassi Alexander, Stults John T.
Принадлежит:

A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness. 120-. (canceled)21. A method of identifying a biological state of a subject , the method comprising:(a) obtaining a biological sample from the subject, wherein the biological sample is a fluid sample;(b) depleting the biological sample by removing highly abundant proteins to yield a depleted sample, wherein the highly abundant proteins are present in the biological sample at a concentration of at least 10 μg/mL;(c) assaying proteins in the depleted sample to detect a plurality of biomarkers and generate a biomarker pattern; and(d) processing the biomarker pattern using a trained classifier, wherein the trained classifier assigns one or more biological states to the biomarker pattern based on the concentration of at least one biomarker of the plurality of biomarkers to identify the biological state of the subject.22. The method of claim 21 , wherein the at least one biomarker of the plurality of biomarkers is present in the biological sample at a concentration of no more than 7 pg/ml.23. The method of claim 21 , wherein the at least one biomarker of the ...

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Номер записи: 61
18-02-2021 дата публикации

Test Sensor Cartridges And Sensor-Dispensing Instruments

Номер: US20210048427A1
Автор: Creaven John P., Reynolds Jeffery S.
Принадлежит:

The cartridge comprises a housing, a plurality of test sensors, a mechanical mechanism, and a pusher assembly. The housing forms at least one opening therethrough. The plurality of test sensors is stacked in the housing. The plurality of test sensors is adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the plurality of test sensors in a first direction. One of the plurality of test sensors is positioned for extraction from the cartridge. The pusher assembly is adapted to push one of the plurality of test sensors from the cartridge. The pusher assembly includes a ferromagnetic material or a magnet. 192-. (canceled)93. A cartridge comprising:a housing forming at least one opening therethrough;a plurality of test sensors being stacked in the housing, the plurality of test sensors being adapted to assist in testing at least one analyte, the plurality of test sensors including at least one sensor electrical contact;a mechanical mechanism adapted to urge the plurality of test sensors in a first direction, one of the plurality of test sensors being positioned for extraction from the cartridge; anda lid being moveable between a closed position and an open position such that the lid seals the opening in the closed position, the lid including at least one lid electrical contact, wherein during the movement of the lid from the closed position to the open position, the at least one electrical contact contacts the at least one sensor contact of one of the plurality of test sensors,wherein during movement of the lid from the open position to the closed position, the lid extracts one of the plurality of test sensors at least partially through the opening.94. The cartridge of claim 93 , wherein the lid includes a plurality of electrical contacts and each of the plurality of test sensors includes a plurality of sensor contacts.95. The cartridge of claim 93 , further comprising a plurality of retainer tabs to assist in sealing the ...

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Номер записи: 62
14-02-2019 дата публикации

Biological Fluid Collection Device and Biological Fluid Separation and Testing System

Номер: US20190046096A1
Автор: Gelfand Craig A., Marchiarullo Daniel J., Rothenberg Ashley Rachel, Wilkinson Bradley M.
Принадлежит:

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results. 1. A biological fluid separation device , comprising:a rotatable body having a center of rotation, an outer periphery, and a body inlet, the body inlet adapted to receive a multi-component blood sample;a separation chamber defined within the rotatable body and in fluid communication with the body inlet and having a chamber outlet spaced apart from the body inlet, the separation chamber adapted to receive the multi-component blood sample; anda blood component chamber defined within the rotatable body and in fluid communication with the chamber outlet,wherein when the separation chamber contains the multi-component blood sample and a rotational force is applied to the rotatable body, a first blood component of the multi-component blood sample passes from the separation chamber into the blood component chamber and a second blood component of the multi-component blood sample is retained within the separation chamber,wherein the blood component chamber is disposed adjacent the center of rotation and the separation chamber is disposed adjacent the outer periphery of the rotatable body, andwherein the body inlet includes an engagement portion configured to receive a transfer device for closed transfer of a multi-component blood sample to the separation device.2. The biological fluid separation device of claim 1 , wherein the first blood component is a plasma component of the multi-component blood sample and the second blood component is a ...

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Номер записи: 63
03-03-2022 дата публикации

Biological Fluid Collection Device and Collection Module

Номер: US20220065758A1
Автор: Edelhauser Adam, Ivosevic Milan
Принадлежит:

A biological fluid collection device that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications. 1. A collection module adapted to receive a sample , the collection module comprising:a housing having an inlet port and an outlet port, the inlet port and the outlet port in fluid communication;a mixing chamber disposed between the inlet port and the outlet port;a sample stabilizer disposed between the inlet port and the outlet port; anda collection chamber disposed between the mixing chamber and the outlet port, the collection chamber including a first deformable portion and a second deformable portion, wherein the mixing chamber receives the sample and at least a portion of the sample stabilizer therein,wherein the first deformable portion and the second deformable portion are transitionable between an initial position in which the sample is contained within the collection chamber and a deformed position in which a portion of the sample is expelled from the collection chamber.2. The collection module of claim 1 , wherein the first deformable portion and the second deformable portion are simultaneously squeezed to transition from the initial position to the deformed position.3. The collection module of claim 1 , wherein the mixing chamber further comprises:a first curved wall having a first inlet end and a first exit end; anda second curved wall having a second inlet end and a second exit end, ...

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Номер записи: 64
23-02-2017 дата публикации

Biological Fluid Collection Device and Biological Fluid Separation and Testing System

Номер: US20170049372A1
Автор: Gelfand Craig A., Marchiarullo Daniel J., Rothenberg Ashley Rachel, Wilkinson Bradley M.
Принадлежит:

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results. 1. A biological fluid separation device , comprising:a rotatable body having a center of rotation and an outer periphery, the rotatable body having a body inlet adapted to receive a multi-component blood sample;a separation chamber defined within the rotatable body and in fluid communication with the body inlet and having a chamber outlet spaced apart from the body inlet, the separation chamber adapted to receive both the multi-component blood sample; anda blood component chamber defined within the rotatable body and in fluid communication with the chamber outlet, wherein when the separation chamber contains the multi-component blood sample and a rotational force is applied to the rotatable body, a blood component of the multi-component blood sample passes from the separation chamber into the blood component chamber and a second component of the multi-component blood sample is retained within the separation chamber,wherein the blood component chamber is disposed adjacent the center of rotation and the separation chamber is disposed adjacent the outer periphery of the rotatable body.2. The biological fluid separation device of claim 1 , wherein the blood component is a plasma component of the multi-component blood sample and the second component is a cellular component of the multi-component blood sample.3. The biological fluid separation device of claim 1 , further comprising a diagnostic chamber in fluid communication with the ...

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Номер записи: 65
23-02-2017 дата публикации

NON-INVASIVE BLOOD MEASURING DEVICE

Номер: US20170049393A1
Автор: HYUN Ki Bong
Принадлежит:

Provided is a non-invasive blood measuring device comprising: a fixture which in part or in whole is buried in bone tissue of a patient; an abutment provided in a space inside the fixture; a sensing unit including biosensors for measuring a substance in the blood; a filter through which the substance in the blood to be measured is passed through; and an outcall unit. 1. A non-invasive blood measuring device comprising:a fixture including a internal space fixture including an open region and a fixture through hole penetrating through the internal space fixture, and partially or entirely embedded in bone tissue of a patient;an abutment positioned in the internal space fixture;a sensing unit including a biosensor measuring a constituent of blood introduced through the fixture through hole and provided within the abutment;a filter allowing a constituent of blood as a measurement target to pass therethrough and positioned in the fixture through hole; anda transmission unit transmitting a signal generated by the biosensor outwardly.2. The non-invasive blood measuring device of claim 1 , wherein the abutment includes an internal abutment space including an open region and an abutment through hole penetrating through the internal abutment space claim 1 , a housing inserted into the internal abutment space or integrated with the abutment is further provided claim 1 , the housing includes a housing through hole positioned in a location corresponding to the abutment through hole claim 1 , and one or more biosensors are installed within the housing.3. The non-invasive blood measuring device of claim 2 , wherein the filter includes a first filter positioned between an inner surface of the fixture and an outer surface of the abutment and a second filter positioned between an inner surface of the abutment and an outer surface of the housing claim 2 , or both of the first filter and the second filter.4. The non-invasive blood measuring device of claim 1 , wherein the abutment is ...

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Номер записи: 66
13-02-2020 дата публикации

Bodily fluid sample collection and transport

Номер: US20200047179A1
Автор: Clarissa LUI, Daniel Young, Elizabeth A. Holmes, Michael Chen
Принадлежит: Theranos IP Co LLC

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.

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Номер записи: 67
22-02-2018 дата публикации

Biological Fluid Separation Device and Biological Fluid Separation and Testing System

Номер: US20180049685A1
Автор: Marchiarullo Daniel J., Wilkinson Bradley M.
Принадлежит:

A biological fluid separation device that is adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid separation device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid separation device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid separation device of the present disclosure also provides a closed separation and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid separation device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid separation device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results. 1. A biological fluid separation device adapted to receive a multi-component blood sample , the biological fluid separation device comprising:a separation cartridge having an inlet port and a flow channel defined within the cartridge in fluid communication with the inlet port, the flow channel containing a separation element adapted to separate the multi-component blood sample into at least a first component and a second component, a first collection chamber defined within the cartridge in fluid communication with the flow channel and including a first outlet port, and a second collection chamber defined within the cartridge in fluid communication with the flow channel and including a second outlet port, the second collection chamber isolated from the first collection chamber.2. The biological fluid separation device of claim 1 , wherein the first component is a cellular portion of the multi-component blood sample and the second component is a plasma portion of the multi-component blood sample.3. The biological fluid separation ...

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Номер записи: 68
22-02-2018 дата публикации

Biological Fluid Separation Device and Biological Fluid Separation and Testing System

Номер: US20180049686A1
Автор: Marchiarullo Daniel J., Wilkinson Bradley M.
Принадлежит:

A biological fluid separation device that is adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid separation device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid separation device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid separation device of the present disclosure also provides a closed separation and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid separation device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid separation device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results. 1. A biological fluid separation cartridge , comprising:a housing having an inlet port and a flow channel defined within the housing in fluid communication with the inlet port;a first collection chamber defined within the housing in fluid communication with the flow channel and including a first outlet port having a valve comprising a deformable wall member and a septum, wherein the septum covers the first outlet port; anda second collection chamber defined within the housing in fluid communication with the flow channel and including a second outlet port, the second collection chamber isolated from the first collection chamber, and the second outlet port spaced apart from the first outlet port.2. The biological fluid separation cartridge of claim 1 , wherein the flow channel has a spiral shape.3. The biological fluid separation cartridge of claim 1 , wherein at least a portion of the flow channel contains a sample stabilizer.4. The biological fluid separation cartridge of claim 1 , further comprising an inlet channel in fluid ...

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Номер записи: 69
22-02-2018 дата публикации

DEVICE FOR COLLECTING A LIQUID SAMPLE BY CAPILLARITY

Номер: US20180050339A1
Автор: POHER Vincent, Pouteau Patrick
Принадлежит:

A device for collecting a liquid sample by capillarity includes distinct first and second elements having respective male and female parts. The male part comprises a channel having a transverse section. The female part comprises a peripheral wall that transversely delimits a cavity to house the male part. A part of the peripheral wall forms a cap to close the transverse section when the female part houses the male part. 115-. (canceled)16. An apparatus comprising a device for collecting a liquid sample by capillarity , said device comprising a first element and a second element , wherein said first element comprises a male part , wherein said second element , which is distinct from said first element , comprises a female part , wherein said male part comprises a channel having an transverse section , wherein said channel extends along a longitudinal axis between a first end and a second end , wherein said first end is an input end , wherein said channel is formed by a channel-bottom longitudinal wall bordered by two lateral walls that form sides of the channel , wherein said female part comprises a peripheral wall , wherein said peripheral wall transversely delimits a cavity to house said male part , wherein a part of said peripheral wall forms a first cap to close said transverse section when said female part houses said male part.17. The apparatus of claim 16 , wherein at least one of said sides is arranged such that claim 16 , when said female part houses said male part claim 16 , a distance between two walls of said channel decreases towards a transverse edge of said channel claim 16 , wherein said distance is measured in a plane transverse to said longitudinal axis.18. The apparatus of claim 16 , further comprising a plate having a rectangular transverse section and a top longitudinal face claim 16 , wherein said plate forms said male part claim 16 , wherein said channel is disposed at a level of said top longitudinal face.19. The apparatus of claim 18 , ...

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Номер записи: 70
10-03-2022 дата публикации

DELIVERING AND/OR RECEIVING FLUIDS

Номер: US20220071534A9
Автор: Bernstein Howard, Boccuti A. David, Chickering, Dadgar Maisam, Davis Shawn, Fisher Greg, Gonzalez-Zugasti Javier, Haghgooie Ramin, III Donald E., James Scott, Levinson Douglas A., Michelman Mark, Miller Richard L., Morse Christopher J.
Принадлежит: YourBio Health, Inc.

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. 130-. (canceled)31. A device for receiving fluid from a subject , comprising:a device actuator;a housing including an opening to receive fluid into the housing;a flow activator comprising at least one needle;a vacuum source;a deployment actuator configured to move the flow activator in a deployment direction;an effector and an effector guide, wherein the effector is guided in motion via the effector guide in the deployment direction and a retraction direction, wherein the deployment actuator is held by the effector; anda retraction actuator configured to move the effector in the retraction direction.32. The device of claim 31 , wherein a portion of the deployment actuator is displaceable relative to the effector.33. The device of claim 31 , wherein the effector guide includes a slot that receives the effector claim 31 , wherein the effector moves along the slot in the deployment direction and in the retraction direction.34. The device of claim 31 , wherein the effector guide includes a first slot and a second slot claim 31 , wherein the effector moves along the first slot and the second slot in the deployment direction and the retraction direction.35. The device of claim ...

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Номер записи: 71
10-03-2022 дата публикации

Mixing Element for Container Assemblies

Номер: US20220072489A1
Автор: Kuan Chee Mun
Принадлежит:

A container assembly with improved mixing dynamics for mixing substances in preparation for injection by an injection device or for the dispersion of additives in the collection and analysis of biological samples is disclosed. In one configuration, the container assembly includes a first mixing element protruding into an interior of a container. With the container rotated about its longitudinal axis, the first mixing element forms at least one vortex which effectuates mixing of a first substance provided within the container interior and a second substance provided within the container interior. 1. A container assembly comprising:a container having a first end, a second end, and a sidewall extending therebetween and defining a container interior, the container defining a container longitudinal axis;a first closure sealing the first end of the container;a second closure sealing the second end of the container; anda first mixing element protruding into the container interior and a second mixing element protruding into the container interior, the first and second mixing elements located at opposite ends of the container, whereby, with the container rotated about the container longitudinal axis, the first and second mixing elements form at least one vortex which effectuates mixing of a first substance provided within the container interior and a second substance provided within the container interior.2. The container assembly of claim 1 , wherein the first mixing element is located on a portion of the first closure.3. The container assembly of claim 1 , wherein the first mixing element is located on a portion of the second closure.4. The container assembly of claim 1 , wherein the first mixing element is located on an internal surface of the sidewall of the container.5. The container assembly of claim 1 , wherein the first mixing element forms an asymmetric mixing pattern within at least one of the first and second substances provided within the container interior.6. ...

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Номер записи: 72
03-03-2016 дата публикации

PERSONAL DIAGNOSTIC DEVICE HAVING A FLUIDIC CIRCUIT WITH A PLURALITY OF ANALYSIS CHAMBERS

Номер: US20160058354A1
Автор: Bollella Donald, Pal Andrew Atilla, Phan Brigitte Chau, Valencia Ramoncito M.
Принадлежит:

Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power. 1. A personal diagnostic device for analysis of a fluid sample , comprising:a sample acquisition layer for obtaining a fluid sample from a user;a fluidic processing layer in fluid communication with said sample acquisition layer and configured to process said fluid sample, said fluidic processing layer including a fluidic circuit comprising a plurality of analysis chambers, said fluidic circuit configured to direct said fluid sample to one or more of said plurality of analysis chambers for sample processing, detection, and analysis;an assay results detection layer having a detector for detecting diagnostic results derived from said processing of said fluid sample;a signal processing unit configured to display at least some of said diagnostic results of said fluid sample; said sample acquisition layer, said fluidic processing layer, and said assay results detection layer being in communication with each other; and said one or more of said plurality of analysis chambers and said ...

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Номер записи: 73
21-02-2019 дата публикации

Relatively small devices applied to the skin, modular systems, and methods of use thereof

Номер: US20190053740A1
Автор: David R. Walt, Donald E. Chickering, III, Douglas A. Levinson, Howard Bernstein, Ramin Haghgooie, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

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Номер записи: 74
21-02-2019 дата публикации

Assay and Point of Care Device Utilizing Saliva for Diagnosis and Treatment of Neurological Conditions Affecting Brain Health

Номер: US20190053744A1
Автор: Aaron Dadas, Damir Janigro, Edward J. Rapp
Принадлежит: Flotbi Inc

The present invention relates to systems and methods for assessing brain health and detecting neurological conditions. The invention more particularly relates to systems and methods for diagnosing neurological conditions and analyzing rain health from analysis of a biological fluid sample, such as a saliva sample, that looks for and determines the significance of peripheral markers of blood-brain barrier disruption. The present invention further provides a diagnostic system and method with a higher negative predictive value of brain injury than currently known tests are able to provide, so as to reduce the need for computerized tomography or magnetic resonance imaging scans to affirmatively determine that brain or cerebrovascular injury has not occurred, and thus to improve suspected brain injury patient health care while reducing the expense of such care.

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Номер записи: 75
05-03-2015 дата публикации

PLACENTAL BLOOD EXTRACTION DEVICE

Номер: US20150065918A1
Автор: Ho Saey Tuan Barnabas, Leal Mari Krizia Ong, TAN Gabriel, Toh Tiong Han, WRIGHT Ron
Принадлежит:

A placental blood extraction device comprises a receptacle for receiving a placenta with umbilical cord, the receptacle comprising a compartment arranged to receive the placenta; and a tube extending from the compartment for receiving the umbilical cord; wherein the receptacle is selectively removable from the device for receiving the placenta. The placental blood extraction device may comprise a pressure application device for applying pressure to a placenta, the pressure application device comprising a plurality of pressing members for applying pressure on a plurality of regions of the placenta. 1. A placental blood extraction device comprising:a receptacle for receiving a placenta with umbilical cord, the receptacle comprisinga compartment arranged to receive the placenta; anda tube extending from the compartment for receiving the umbilical cord;wherein the receptacle is selectively removable from the device for receiving the placenta.2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. A placental blood extraction device comprising:a pressure application device for applying pressure to a placenta, the pressure application device comprising a plurality of pressing members for applying pressure on a plurality of regions of the placenta.9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. (canceled)23. (canceled)24. (canceled)25. (canceled)26. (canceled)27. (canceled)28. (canceled)29. (canceled)30. (canceled)31. (canceled)32. (canceled)33. (canceled)34. (canceled)35. (canceled)36. (canceled)37. (canceled)38. (canceled)39. A cannula assembly comprising:a catheter;a housing mounted to a portion of said catheter such that a length of catheter projects from said housing;an introducer in sliding engagement with said housing and arranged coaxially with said catheterwherein the introducer is movable from an ...

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Номер записи: 76
10-03-2016 дата публикации

PERSONAL DIAGNOSTIC DEVICE HAVING AN AIR SAMPLE COLLECTION UNIT AND A FLUIDIC CIRCUIT

Номер: US20160066828A1
Автор: Bollella Donald, Pal Andrew Atilla, Phan Brigitte Chau, Valencia Ramoncito M.
Принадлежит:

Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power. 1. A personal diagnostic device , comprising:at least one air sample collection unit for obtaining an air sample from an ambient environment of a user, said at least one air sample collection unit configured to detect at least one airborne contaminant;a user sample acquisition layer for obtaining a fluid sample from said user;a fluidic processing layer in fluid communication with said user sample acquisition layer and configured to process said fluid sample, said fluidic processing layer including a fluidic circuit comprising a plurality of analysis chambers, said fluidic circuit configured to direct said fluid sample to said one or more of said plurality of analysis chambers for sample processing, detection, and analysis;an assay results detection layer having a detector for detecting diagnostic results derived from said processing of said fluid sample;a signal processing unit configured to display detection of said at least one air born contaminant and display at least some of said ...

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Номер записи: 77
27-02-2020 дата публикации

SYSTEMS AND METHODS FOR PARENTERALLY PROCURING BODILY-FLUID SAMPLES WITH REDUCED CONTAMINATION

Номер: US20200060596A1
Автор: Patton Richard G.
Принадлежит: MAGNOLIA MEDICAL TECHNOLOGIES, INC.

The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media. 1. A system for parenterally procuring bodily-fluid samples from a patient with minimal contamination , the system comprising: a first sterile needle configured and arranged for insertion into a patient, the first sterile needle comprising a first lumen configured and arranged for withdrawing patient bodily fluids and passing the withdrawn bodily fluids through the first lumen,', 'a second sterile needle in fluid communication with the first sterile needle, the second sterile needle comprising a second lumen configured and arranged for passing withdrawn bodily fluids through the second lumen, and, 'a bodily-fluid withdrawing device, the bodily-fluid withdrawing device comprising'}at least one vacuum-sealed pre-sample reservoir, each of the at least one vacuum-sealed pre-sample reservoirs configured and arranged for collecting and storing patient bodily fluid withdrawn from the bodily-fluid withdrawing device; andat least one vacuum-sealed sample vessel, each of the at least one vacuum-sealed sample vessels configured and arranged for collecting and storing patient bodily fluid withdrawn from the bodily-fluid withdrawing device, each of the at least one sample vessels containing a culture medium.2. The system of claim 1 , wherein each of the at least one vacuum-scaled pre-sample reservoirs defines a first mouth with a first ...

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Номер записи: 78
08-03-2018 дата публикации

DIAGNOSTICS SYSTEMS AND METHODS

Номер: US20180064384A1
Автор: FRAIWAN ARWA, Galen Peter, GRIMBERG BRIAN T., GRUPP DANIEL E., GURKAN Umut Atakan, HASAN MUHAMMAD NOMAN, HOYT JOSHUA KING, Thorne James
Принадлежит:

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient. 1. A point-of-care diagnostic system , comprising: a blood sample chamber that is structured to receive a patient blood sample, the patient blood sample containing one or more hemoglobin types, and to store the patient blood sample within the blood sample chamber;', 'an electrophoresis strip structured to receive at least a portion of the patient blood sample from the blood sample chamber and to receive a selectively applied electric current;, 'a cartridge having a cartridge receptacle shaped to receive the cartridge and initiate an electrophoresis diagnostic process in response to receiving the cartridge;', 'an electrophoresis module structured to cause the selectively applied electric current to be applied to the electrophoresis strip of the cartridge, the electrophoresis strip having thereon received at least a portion of the patient blood sample;', 'an electrophoresis band detection module structured to detect one or more bands of at least a portion of the patient blood sample on the electrophoresis strip caused by the selectively applied electric current and to generate band detection data based on the one or more bands of the at least a portion of the patient blood sample;, 'a reader having receive the band detection data;', 'analyze the band detection data to determine one or more band characteristics for each of the one or more bands, each of the one or more bands corresponding ...

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Номер записи: 79
09-03-2017 дата публикации

BLOOD AND BIOLOGICAL SAMPLE COLLECTION DEVICE AND METHOD

Номер: US20170065215A1
Автор: Mink Ronald William, Piacentini Stephen Carl, Smith Paul Robert
Принадлежит: Sedia Biosciences Corporation

Specially designed collection strips and their processing. By using specially designed collection strips, having a backer and one or more absorbent pads, in conjunction with a unique processing method, the processes of analyzing biological samples such as blood, or the like, may be done efficiency with the elimination of cross contamination risk. Identification of the sample stays with the sample throughout the process as it resides on the collection strip. The strip absorbs a known volume. The sample with identification is placed directly in an elution solution, without mechanically separating the sample from its identification information. Elimination of the need for mechanical separation tends to reduce cross contamination, as well as reducing sample processing time. 1. A blood collection device that does not require punching , or folding to obtain a sample for processing comprising:a flat rectangular elongated backer having a first end and a second end;a planar label area disposed on the first end upon which identifying information of a collected sample is recorded; anda separate absorbent pad attached at the second end of the flat rectangular elongate backer that does not require punching to obtain a sample whereby a blood sample is applied to the absorbent pad and dried for later testing, the construction of the blood collection device not requiring a folding, a punching out, or detachment of a portion of the blood collection device containing the blood sample, and whereby the identifying information of the collected sample stays affixed to the sample during processing of the sample.2. The blood collection device of claim 1 , in which the absorbent pad is cellulose.3. The blood collection device of claim 1 , in which the absorbent pad is polyester.4. The blood collection device of claim 1 , in which the absorbent pad is glass fiber.5. The blood collection device of claim 1 , in which the absorbent pad is treated with a detergent.6. The blood collection device ...

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Номер записи: 80
09-03-2017 дата публикации

Filtering in pre-evacuated containers

Номер: US20170065217A1
Автор: Bell William, Montagu Jean I., Montagu Sasha
Принадлежит:

An independent blood filter device depends on flow geometry to deliver blood serum or plasma free of detrimental levels of hemoglobin. It depends critically on an upstream flow rate or pressure differential limiting control element or device that limits the rate of change of pressure differential across the filter element. Pre-evacuated versions can be used to simultaneously draw blood from a living being and provide pressure differential across the filter element between an evacuated collector and a supply end open to atmosphere. A unit pressurized by hand motion employs the external shape of a partially filled blood collection tube as a piston to produce pressure in advance of the control element or device to create the pressure differential across the filter element to a collector vented to atmosphere. The control element or device is disclosed in numerous forms, including specially sized flow constrictions and compliant arrangements. 1. A filtering device for filtering blood to obtain serum or plasma in a container , the container having access at both ends , a filter located within the container , and a flow rate or pressure differential limiting control element , the limiting element located upstream of the filter.2. The filtering device of in which the container is partially evacuated.3. The filtering device of wherein the limiting control element is located outside the container.4. The filtering device of wherein the limiting control element is integral with a blood drawing needle assembly.5. (canceled)6. The filtering device of wherein the container during operation is partially pressurized.7. The filtering device of any of the foregoing wherein the limiting control element or device is located inside the container.8. A filtering device claim 1 , comprising a pre-evacuated container claim 1 , a filter located within the container claim 1 , and a flow rate or pressure differential limiting control element.9. The filtering device of wherein the control ...

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Номер записи: 81
11-03-2021 дата публикации

MEDIUM WITH HYDROPHOBIC PATTERNS AND BREAK LINES DEFINING A BLOOD COLLECTION VOLUME

Номер: US20210068730A1
Автор: Christian Kate E., Grant Russell, Johnson Brandon T., Tobiason Lachlan
Принадлежит:

A blood sample collection and/or storage device includes a medium, such as a membrane or microstructured environment for storing a body fluid sample such as a blood sample. The medium has hydrophobic patterns formed thereon or therein to define precisely dimensioned channels for fluid flow or fluid retention. Break lines in the medium defined predetermined areas (or volumes) of the medium. After sample collection, the medium may be broken apart along the break lines to obtain a precisely measured amount of the fluid sample. 1. A fluid sample collection device comprising:a medium having a channel defined by at least one hydrophobic region; andat least one break line intersecting the channel, and defining a predetermined area of the medium.2. The device medium of wherein at least one break line defines an area providing a predetermined volume for collection of a fluid sample.3. The device medium of further comprising two or more break lines that define corresponding multiple areas of the medium coated with reagents claim 1 , and with at least one selected reagent coating a selected area being different from another reagent coating another area.4. The device of wherein the hydrophobic region further defines one or more fluid pathways.5. The device of wherein the hydrophobic region regulates a speed of fluid movement.6. The device of wherein the hydrophobic region defines a tortuous path to slow fluid movement through the device.7. The device of wherein the hydrophobic region slows t fluid movement claim 5 , in turn partially saturating the medium to slow capillary action.8. The device of wherein the medium further comprises multiple layers.9. The device of wherein a first layer is a first membrane that collects and directs a sample to a second layer by way of a channel defined by the hydrophobic region.10. The device of wherein one of the layers is a lateral flow strip.11. The device of wherein one of the layers contains a reagent.12. The device of wherein one of the ...

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Номер записи: 82
08-03-2018 дата публикации

FLUID INJECTION AND SAFETY SYSTEM

Номер: US20180067019A1
Автор: Butler Michael, Chiou Jeffrey T., Lim Eugene, Rivas Gil
Принадлежит:

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port. 1. (canceled)2. A medical device and automated setup instruction system comprising: a non-disposable subsystem including at least one of a valve, a sensor or a pump; and', 'a removable cartridge configured to hold and prepare a sample of bodily fluid for analysis, the removable cartridge being comprising a safety port comprising an opening, the removable cartridge configured to be in fluid communication with a source of an anti-coagulant agent comprising an adapter that is configured to engage the safety port, and wherein the source of the anti-coagulant agent is not configured to engage conventional medical fittings;, 'a fluid system comprisinga display configured to be visible to a medical device user when the user is preparing the medical device for use in a medical setting;a computer memory configured to store setup information and protocols that are specific to the medical device; one or more sensors configured to detect configuration of components of the medical device and/or data regarding the environment in which the device is used;', 'one or more direct user input portions configured to accept input from the user relating to user- ...

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Номер записи: 83
08-03-2018 дата публикации

DIAGNOSTICS SYSTEMS AND METHODS

Номер: US20180067101A1
Автор: Galen Peter, GRIMBERG BRIAN T., GRUPP DANIEL E., Gurkan Umat Atakan, HOYT JOSHUA KING, Sayler David John
Принадлежит:

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as a magneto-optical system that measures a light transmission differential through the patient sample in varying magnetic fields. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disease, infection and/or condition of the patient. 1. A point-of-care diagnostics system , comprising:a cartridge having a blood sample chamber that is structured to receive a patient blood sample and to store the patient blood sample within the blood sample chamber; a cartridge receptacle shaped to receive the cartridge;', 'a magnetic field source structured to selectively apply a magnetic field to at least the blood sample chamber of the cartridge when the cartridge is received within the cartridge receptacle;', 'a light source positioned to selectively transmit light through the patient blood sample in the blood sample chamber of the cartridge when the cartridge is received in the cartridge receptacle;', 'a light detector positioned to sense one or more characteristics of the light transmitted through the blood sample and to generate light detection data based, at least in part, on the sensed one or more characteristics of the light transmitted through the blood sample;', receive the light detection data;', 'analyze the received light detection data to identify whether at least one compound that is sensitive to the applied magnetic field is present in the blood sample based at least in part on the one or more sensed characteristics of the light transmitted through the blood sample, the at least one compound that is sensitive to the applied magnetic field including hemozoin;', 'when at least one compound that is sensitive to the applied magnetic field ...

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Номер записи: 84
09-03-2017 дата публикации

Systems, Methods, and Devices for Sample Collection, Stabilization and Preservation

Номер: US20170067803A1
Автор: Alicia Jackson, Rowan Chapman
Принадлежит: Drawbridge Health Inc, General Electric Co

Herein, systems and methods are disclosed including a sample acquisition component (SAC) for user-friendly sample collection, a separation component for optional separation of plasma, and one or more stabilization components for stabilizing analytes. In a particular embodiment, the system and methods are directed towards sample collection and stabilization with optional sample separation. Other embodiments can perform any combination of collection, separation, stabilization or detection.

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Номер записи: 85
12-03-2015 дата публикации

Retractable Needle for Blood Gas Sampling

Номер: US20150073303A1
Автор: Shaw Thomas J., Small Mark, Zhu Ni
Принадлежит:

A medical device having a frontal attachment and a connector housing having at least a body part of an associated medical apparatus, the frontal attachment slidably engaging the connector housing and having a forwardly projecting, rearwardly biased needle and a needle retraction assembly, and the connector housing having a needle retraction cavity laterally offset from the needle in a first position, the needle retraction cavity being selectively movable relative to the frontal attachment following use to reposition the needle retraction cavity into alignment with the needle to permit retraction. The subject device is desirably specially modified for use in blood gas sampling by the addition of a filter plug. 1. A medical device comprising a retractable needle useful for blood and blood gas sampling and selectively attachable to and detachable from a conventional needleless syringe, the medical device comprising a frontal attachment further comprising a forwardly projecting needle, a needle retraction assembly and a filter plug laterally spaced apart from the needle retraction assembly; and a connector housing further comprising a connector body attachable to a needleless syringe and a needle retraction chamber laterally spaced apart from the connector body; the frontal attachment and the connector housing being disposed in adjacent and laterally slidable relation to each other with a sealing element disposed between them to restrict fluid leakage during any relative movement between them, and the filter plug being alignable with the connector body when the needle is aligned with the needle retraction chamber following relative sliding movement between the frontal attachment and the connector housing to prevent leakage of blood out of the medical device while permitting excess air to be expelled through the filter plug by advancing the plunger relative to the filter plug following needle retraction. This application claims the benefit under 35 U.S.C. §119(e) of U.S. ...

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Номер записи: 86
29-05-2014 дата публикации

Device For Continuous Measuring Of An Analyte

Номер: US20140148669A1
Автор: Garcia Saban Javier Francisco, Marsinyach Montfort Jordi
Принадлежит:

The present invention relates to a device for continuous measuring of an analyte which allows monitoring the blood or interstitial glucose level in a minimally invasive, minimally detrimental and painless manner for which it basically comprises a fixed element () on which there is fixed a disposable and exchangeable element () incorporating an automated multi-puncturing system programmable over time comprising a plurality of puncturing units each formed by a micro-needle (), means for driving said micro-needle (), an elastic spring () returning it to its resting state and a biosensor wherein the glucose data which is subsequently transmitted to an external reading and management device is extracted. 112233. Device for continuous measuring of an analyte comprising a fixed element () which is placed on the user's skin and which in turn comprises an intelligent core for controlling a disposable and exchangeable element () coupled thereto , wherein said disposable element () incorporates an automated multi-puncturing system programmable over time comprising a plurality of puncturing units for sampling , characterized in that each of said puncturing units comprises a micro-needle () and means for driving said micro-needle () such that they allow the puncturing at different depths.231553. Device for continuous measuring of an analyte according to claim 1 , characterized in that the means for driving the micro-needles () comprise a winding () responsible for inducing an electromagnetic field on a ferromagnetic material () integral to the micro-needle () such that it is displaced to the sampling position in a manner proportional to the intensity of the field induced.3. Device for continuous measuring of an analyte according to the preceding claims claim 1 , characterized in that the puncturing units are formed by:{'b': '4', 'claim-text': [{'b': 3', '5', '6', '7', '3', '8', '4, 'the micro-needle () surrounded in its upper portion by the piece made of ferromagnetic material ...

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Номер записи: 87
16-03-2017 дата публикации

Biological Fluid Collection Device and Biological Fluid Separation and Testing System

Номер: US20170071519A1
Автор: Gelfand Craig A., Marchiarullo Daniel J., Rothenberg Ashley Rachel, Wilkinson Bradley M.
Принадлежит:

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results. 1. A biological fluid collection device , comprising:a lancet housing having an inlet port and an interior defining a first flow channel in fluid communication with the inlet port and a second flow channel in fluid communication with the first flow channel, wherein at least a portion of the second flow channel is diverted from the first flow channel;a puncturing element moveable between a pre-actuated position wherein the puncturing element is retained within the interior of the housing and a puncturing position wherein the puncturing element extends through the inlet port of the housing and provides fluid communication with the first flow channel; anda transfer cartridge having a reservoir, wherein the second flow channel is in fluid communication with the reservoir of the transfer cartridge.2. The biological fluid collection device of claim 1 , wherein the first flow channel is adapted to receive a blood sample therein.3. The biological fluid collection device of claim 2 , wherein the first flow channel is dimensioned to receive the first blood provided to the flow channel.4. The biological fluid collection device of claim 1 , wherein the first flow channel comprises a reservoir region spaced apart from the inlet port claim 1 , and a truncated region spaced apart from the reservoir region claim 1 , wherein the second flow channel is provided in fluid communication with the truncated region.5. The biological fluid collection ...

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Номер записи: 88
16-03-2017 дата публикации

METHOD AND APPARATUS FOR ACQUIRING BLOOD FOR TESTING

Номер: US20170071520A1
Автор: Bischofberger Allen A., Guo Yibo, Kushon Stuart A., Rahn Peter, Rudge James, Welch Emmet
Принадлежит: Neoteryx, LLC.

A blood sampling device is provided having holder with a manipulating end and an absorbent probe on the opposing end. The probe is of hydrophilic polymer sized to directly absorb a predetermined volume of up to about 30 microliters of blood. Ribs on the holder position the probe within a compartment of a container to prevent contact with the container. The ribs also position the probe within extraction wells. 140-. (canceled)41. A device for collecting bodily fluid , comprising:an elongated and tapered body extending along a longitudinal axis and having a smaller diameter first end and an opposite, larger diameter second end, the second end forming a conical internal recess which recess extends along a first length of the longitudinal axis;an absorbent probe at the first end of the body;three ribs each extending radially outward from the elongated body beginning adjacent the first end and extending along a second length of the elongated body which second length is greater than half the length of the elongated body, each rib having an outwardly extending position stop facing the first end at the same location along the longitudinal axis.42. The device of claim 41 , wherein the absorbent probe is made of a material of sufficient size to absorb for analysis a maximum of about 20 μl of blood in about 2-5 seconds without separating the blood from plasma claim 41 , the probe having a length of less than about 5 mm and a cross-sectional area of less than about 20 mmand a density of less than about 4 g/cc with a majority of the exterior surface of the probe being exposed and available for placing against a fluid sample on a surface to absorb the sample.43. The device of claim 42 , wherein the absorbent probe is inserted into an open end of the body.44. device of claim 42 , wherein an end of the absorbent probe surrounds a portion of the body.45. The device of claim 42 , wherein claim 42 , the absorbent probe has a rounded distal end.46. The device of claim 41 , wherein the ...

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Номер записи: 89
07-03-2019 дата публикации

SYSTEM AND METHOD FOR DETECTING LYSYL OXIDASE-LIKE 2 PROTEIN (LOXL2) AND BREAST CANCER

Номер: US20190072514A1
Автор: Dudik Laurie, Janyasupab Metini, Liu Cheng-Wei, Liu Chung-Chiun, Zhang Yuan
Принадлежит:

A detection system for determining lysyl oxidase-like 2 protein (LOXL2) levels in a bodily sample, includes at least one reaction solution for generating HOupon combination with LOXL2 in the bodily sample, the reaction solution including lysine that can be oxidatively deaminated by LOXL2 to generate α-aminoadipic-δ-semialdehyde (allysine) and hydrogen peroxide (HO). 1. A detection system for determining lysyl oxidase-like 2 protein (LOXL2) levels in a bodily sample , comprising:{'sub': 2', '2', '2', '2, 'at least one reaction solution for generating HOupon combination with LOXL2 in the bodily sample, the reaction solution including dissolved lysine powder as a substrate that can be oxidatively deaminated by LOXL2 to generate α-aminoadipic-δ-semialdehyde (allysine) and hydrogen peroxide (HO);'}{'sub': 2', '2, 'and a biosensor for determining electrochemically the level of generated HO, wherein the biosensor includes a working electrode, a counter electrode and a reference electrode.'}2. The detection system of claim 1 , the bodily sample comprising a bodily fluid selected from the group consisting of blood claim 1 , plasma claim 1 , sera claim 1 , and urine.3. The detection system of claim 1 , the working electrode and counter electrode including catalyst particles for the increasing the rate of electrochemical oxidation-reduction reaction with HOand providing the detection of HOat a lower oxidation potential than without the presence of the catalyst particles.4. The detection system of claim 3 , the catalyst particles comprising nano-particle metallic catalysts.5. The detection system of claim 3 , the catalyst particles comprising a unary metal (M) claim 3 , a binary metal (M-X) claim 3 , a unary metal oxide (MOy) claim 3 , a binary metal oxide (MOy-XOy) claim 3 , a metal-metal oxide composite material (M-MOy) or a combination of which claim 3 , wherein y is less than 3 claim 3 , and M and X are independently selected from a group consisting of Li claim 3 , Na claim ...

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Номер записи: 90
07-03-2019 дата публикации

Arrangement for collection and separation of a body fluid for purposes of analysis and a method relating thereto

Номер: US20190072539A1
Автор: Annelie Brolinson, Björn Eriksson
Принадлежит: Hemcheck Sweden Ab

The present invention relates to an arrangement for collection and separation of a body fluid, e.g. whole blood, for purposes of analysis of a component, e.g. plasma, of a sample of the body fluid. It comprises means for receiving a body fluid, a filter arrangement ( 50 ) comprising a separation filter arrangement for separation of the component(s) to be analysed and a detection filter in communication with the separation filter arrangement. The filter arrangement comprises a pre-filter ( 6 ) having a filter volume adapted to be capable to receive a volume of body fluid exceeding a volume of a sample to be analysed, which comprises a first portion defining a sample zone volume arranged to form a sample zone and at least one second portion defining an excess removal zone volume, forming an excess fluid removal zone the volume of which exceeds said sample zone volume. The separation arrangement defines a separation zone volume, and flow control means ( 11 A, 11 A, 11 B) are provided to control the transportation or flow of body fluid to the separation arrangement forming the separation zone and to the excess fluid removal zone.

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Номер записи: 91
18-03-2021 дата публикации

Blood Collection And Processing Device

Номер: US20210077002A1
Автор: LEE Luke P.
Принадлежит:

A blood sample collection device can provide for collection, storage, amplification, and analysis of a blood sample in a simple, disposable device. The device can include a collection zone for drawing (e.g., via a needle array) or receiving a blood sample, a processing zone for storing and processing blood cells of the blood sample, and a filtration zone for selectively directing the blood cells of the blood sample to an array of wells within the processing zone while leading blood plasma away from the array of wells. Within the wells, which may be prepared to include materials for amplification and various assays, the blood cells can undergo amplification. Externally applied light and/or heat can facilitate amplification. A transparent or translucent window or portion of the collection device can allow an analysis device to take measurements of the array of wells without removing the sample. 1. A sample collection device comprising:a collection zone for accepting a blood sample;an array of wells for entrapping blood cells from the blood sample; anda filtration zone including a plurality of passageways coupling the collection zone to the array of wells, wherein an average diameter of the plurality of passageways decreases from a cross section adjacent the collection zone to a cross section adjacent the array of wells.2. The sample collection device of claim 1 , wherein the collection zone includes a needle array to facilitate drawing the blood sample.3. The sample collection device of claim 1 , further comprising a window located at or adjacent the array of wells for visually exposing the blood cells entrapped within the array of wells to an exterior of the device.4. The device of claim 1 , wherein interior surfaces of the array of wells are made of plasmonic materials coated with a protective layer.521203. The device of claim 4 , wherein the protective layer is made of SiO or A.6. The device of claim 1 , further comprising polymerase chain reaction reagents ...

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Номер записи: 92
18-03-2021 дата публикации

SAMPLE COLLECTION DEVICE

Номер: US20210077003A1
Автор: TAKEUCHI Ippei
Принадлежит:

A sample collection device is a sample collection device including a sample inlet and an internal flow passage for holding a sample sucked from the sample inlet. An anticoagulant for preventing coagulation of the sample is fixed to an inner surface of the inner flow passage of the sample collection device, and density of the anticoagulant fixed on the inner surface of an end portion near the sample inlet of the inner flow passage is higher than density of the anticoagulant fixed on the inner surface of an end portion on an opposite side to the sample inlet of the internal flow passage. 1. A sample collection device comprising:a sample inlet; andan internal flow passage for holding a sample sucked from the sample inlet, whereinan anticoagulant for preventing coagulation of the sample is fixed to an inner surface of the inner flow passage, and density of the anticoagulant fixed on the inner surface of an end portion near the sample inlet of the inner flow passage is higher than density of the anticoagulant fixed on the inner surface of an end portion on an opposite side to the sample inlet of the internal flow passage.2. The sample collection device according to claim 1 , wherein density of the anticoagulant on an inner surface of the internal flow passage is distributed so as to decrease in multiple steps from the end portion near the sample inlet to the end portion on the opposite side to the sample inlet. The present invention relates to a sample collection device for collecting a small amount of blood in a flow passage and performing processing such as centrifugal separation.A sample collection device for collecting a small amount of sample has been proposed and implemented (see Patent Document 1). The sample collection device has a sample inlet for sucking a sample in an end portion, and a fine flow passage for holding a sample sucked from the sample inlet is provided inside. The flow passage is provided with thinness in such a way that a capillary force acts on ...

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Номер записи: 93
23-03-2017 дата публикации

METHODS OF CONSTRUCTING A DIAGNOSTIC CARTRIDGE AND A FLUID STORAGE AND DELIVERY APPARATUS THEREFOR

Номер: US20170080418A1
Автор: Wright David W.
Принадлежит:

A method of constructing a point-of-care diagnostic apparatus and fluid storage and delivery apparatus therefor is provided. The method of constructing the fluid storage and delivery apparatus includes providing a flexible upper layer having a reservoir; providing a flexible lower layer having a valve member; providing a rigid substrate having an upper surface, a lower surface and a through port; disposing a fluid in the reservoir; and sandwiching the rigid substrate between the upper and lower layers and bonding the upper layer to the upper surface of the rigid substrate with the reservoir registered with the through port and bonding the lower layer to the lower surface of the rigid substrate with the valve member registered with the through port. The method of constructing the point-of-care diagnostic apparatus includes fixing the fluid storage and delivery apparatus to a rigid base in selective fluid communication with a reaction chamber. 1. A method of constructing a disposable , point-of-care diagnostic cartridge , comprising:providing a rigid base having opposite upper and lower surfaces with a reaction chamber extending along the upper and lower surfaces and an inlet extending into the upper surface and at least one fluidic channel extending between the reaction chamber and the inlet;providing a flexible upper layer having a reservoir;providing a flexible lower layer having a valve member;providing a rigid substrate having an upper surface and a lower surface with a through port extending through the upper and lower surfaces of the rigid substrate;fixing the flexible upper layer to the upper surface of the rigid substrate with a first adhesive having a first bond force, with the reservoir having a fluid contained therein, wherein the fluid is in fluid communication with the through port;fixing the flexible lower layer to the lower surface of the rigid substrate with the valve member being registered with the through port and the inlet;releasably fixing the ...

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Номер записи: 94
31-03-2022 дата публикации

Devices, systems and methods for ultra-low volume liquid biopsy

Номер: US20220098575A1
Автор: Dirk Van Den Boom, Jim CHAUVAPUN, Mathias Ehrich, Paul OETH
Принадлежит: Juno Diagnostics Inc

Provided herein are devices, systems, kits and methods for obtaining genetic information from cell-free fetal nucleic acids in ultra-low amounts of biological samples. Due to the convenience of obtaining ultra-low amounts of samples, devices, systems, kits and methods can be at least partially employed at a point of need.

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Номер записи: 95
25-03-2021 дата публикации

Biological Fluid Collection Device

Номер: US20210085231A1
Автор: Edelhauser Adam, Ellis Robert, Korec Bartosz Marek, Pratt Joseph Nathan, Torris Anthony V., Wilkinson Bradley M.
Принадлежит:

A biological fluid collection device that allows a blood sample to be collected anaerobically is disclosed. 1. A biological fluid collection device , comprising:a housing having a superior surface and an inferior surface, wherein a portion of the superior surface defines a cavity having a cavity superior surface;a film engageable with the housing, the film having a film inferior surface and a film superior surface, the film transitionable between an initial position in which the film inferior surface is in contact with the cavity superior surface and a fill position in which the film inferior surface is spaced from the cavity superior surface forming a chamber between the film and the housing; andan actuator disposed at least partially within the housing and in communication with the film and the housing, the actuator transitionable between an original position and a depressed position,wherein after actuation of the actuator to the depressed position, as the actuator returns to the original position, the actuator applies a vacuum to the film superior surface.2. The biological fluid collection device of claim 1 , further comprising a second film that seals the inferior surface of the housing.3. The biological fluid collection device of claim 1 , wherein the actuator includes a vent hole.4. The biological fluid collection device of claim 1 , wherein the biological fluid collection device is for anaerobic blood collection of a blood sample.5. A biological fluid collection device claim 1 , comprising:a housing having a superior surface, an inferior surface, an inlet, and an outlet, wherein a portion of the superior surface of the housing defines a cavity having a cavity superior surface, and wherein a portion of the inferior surface of the housing defines a sacrificial flow channel;a venting plug disposed within a portion of the sacrificial flow channel;a film engageable with the housing, the film having a film inferior surface and a film superior surface, the film ...

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Номер записи: 96
12-03-2020 дата публикации

DETECTION DEVICE AND DETECTION METHOD FOR BODY FLUID SEPARATION

Номер: US20200080988A1
Автор: Cheng Chao-Min, LEE Yi-Tzu
Принадлежит:

The present invention provides a detection device for body fluid separation, which comprises the plurality of bottles, the upper knob member having an upper outer casing and an upper inner casing sleeved within the upper outer casing, and the lower knob member having a lower outer casing and a lower inner casing sleeved within the lower outer casing. When the upper outer casing is tightly coupled to the upper inner casing or the lower outer casing is tightly coupled to the lower inner casing, the bottles do not communicate with each other. When the upper outer casing is separated from the upper inner casing or the lower outer casing is separated from the lower inner casing, the bottles communicate with each other. Accordingly, the detection result can be quickly determined by the detection device and detection method for body fluid separation. 1. A detection device for body fluid separation , comprising:a first bottle, having a first opening at one end thereof and a second opening at the other end thereof, wherein the second opening has a first locking structure;an upper knob member and a lower knob member, wherein (i) the upper knob member comprises an upper outer casing and an upper inner casing sleeved within the upper outer casing, (ii) the upper outer casing has a third opening at one end thereof and a fourth opening at the other end thereof facing the first bottle, (iii) the fourth opening has a second locking structure connected to the first opening, (iv) the lower knob member comprises a lower outer casing and a lower inner casing sleeved within the lower outer casing, (v) the lower outer casing has a fifth opening at one end thereof facing the first bottle and a sixth opening at the other end thereof facing away from the first bottle, and (vi) the fifth opening is connected to the first locking structure, and the sixth opening has a third locking structure;a second bottle, having a closed end and an opposite open end facing the lower knob member and being ...

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Номер записи: 97
30-03-2017 дата публикации

Sampling and assay kit, sample holder and method

Номер: US20170087547A1
Автор: Jaakko Rissanen, Jaana Raussi, Jukka Laukkonen, Sanna Eilola
Принадлежит: Orion Diagnostica Oy

A sampling and assay kit comprises a cuvette for holding a quantity of a buffer solution and a sample holder including a capillary tube for obtaining a sample. The sample holder includes a body portion which holds the capillary tube. The body portion when inserted in the cuvette, is effective to position the capillary tube within the cuvette at a predetermined position above the end of the cuvette.

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Номер записи: 98
05-05-2022 дата публикации

CLOT ADHESION PREVENTING AGENT AND BLOOD COLLECTION CONTAINER

Номер: US20220133961A1
Автор: KOMAI Kuniya
Принадлежит:

Provided is a clot adhesion preventing agent capable of suppressing adhesion of clot to the inner wall surface of a blood collection container. The clot adhesion preventing agent according to the present invention includes a polyether compound or a silicone oil, and an amino acid.

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Номер записи: 99
30-03-2017 дата публикации

METHODS AND COMPOSITIONS FOR DETECTING NON-HEMATOPOIETIC CELLS FROM A BLOOD SAMPLE

Номер: US20170089814A1
Автор: Cheng Jing, Huang Mingxian, Lin Ping, OUYANG Joe, Tao Guoliang, WALKER George, Wang Xiaobo, Wu Lei, XU Jia, Xu Junquan, YAMANISHI Douglas T.
Принадлежит: Aviva Biosciences Corporation

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell. 1. A method for detecting a non-hematopoietic cell in a blood sample , which method comprises:a) providing a blood sample;b) removing red blood cells (RBCs) from said blood sample, with the proviso that said RBCs are not removed from said blood sample via a Ficoll gradient centrifugation, and removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; andc) assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.2. The method of claim 1 , wherein the blood sample is a whole blood sample or a peripheral blood sample.3. The method of claim 1 , wherein the non-hematopoietic cell to be detected is a non-hematopoietic tumor cell.4. The method of claim 3 , wherein the non-hematopoietic tumor cell is a cancerous cell or a cancer cell.5. The method of claim 1 , wherein the RBCs are removed by sedimentation claim 1 , filtration claim 1 , selective lysis claim 1 , or binding to a specific binding member that specifically binds RBCs.6. The method of claim 5 , wherein the RBC sedimentation is promoted by specifically binding RBCs to a specific binding member that specifically binds RBCs to induce aggregation of the RBCs.7. The method of claim 5 , wherein the RBCs are removed by filtering the blood ...

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Номер записи: 100